TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 425.704 | Formula: C18H18BrClN2O3
H donors: 2 H acceptors: 3 LogP: 3.51 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: OCCNCc1cnc(c2c1cc(o2)C(=O)c1ccc(cc1)Br)C.Cl
InChi: 1S/C18H17BrN2O3.ClH/c1-11-18-15(13(10-21-11)9-20-6-7-22)8-16(24-18)17(23)12-2-4-14(19)5-3-12;/h2-5,8,10,20,22H,6-7,9H2,1H3;1H
InChiKey: LMICBZQEPBZYLT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	netrin receptor unc5	0.0037	0.0349	0.0126
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Echinococcus granulosus	Immunoglobulin	0.0037	0.0349	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0037	0.0349	0.0126
Schistosoma mansoni	hypothetical protein	0.0107	0.1906	0.1719
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0107	0.1906	0.1805
Trichomonas vaginalis	penicillin-binding protein, putative	0.0031	0.0226	0.0238
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.0037	0.0349	0.0229
Echinococcus multilocularis	netrin receptor unc 5	0.0037	0.0349	0.0229
Trypanosoma brucei	unspecified product	0.0024	0.0051	0.0924
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.3291	0.4807
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Brugia malayi	basement membrane proteoglycan precursor	0.0037	0.0349	0.051
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0031	0.0226	0.033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Echinococcus granulosus	nephrin	0.0133	0.247	0.2377
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0037	0.0349	0.051
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.3291	0.4807
Onchocerca volvulus		0.0107	0.1906	0.685
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0037	0.0349	0.0229
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0349	0.0126
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0031	0.0226	0.0104
Schistosoma mansoni	peroxidasin	0.0037	0.0349	0.0126
Schistosoma mansoni	roundabout	0.0037	0.0349	0.0126
Loa Loa (eye worm)	glutaminase 2	0.033	0.6848	1
Schistosoma mansoni	hypothetical protein	0.026	0.5284	0.5175
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0037	0.0349	0.0229
Schistosoma mansoni	septate junction protein	0.0037	0.0349	0.0126
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0031	0.0226	0.0111
Brugia malayi	Immunoglobulin domain containing protein	0.0037	0.0349	0.051
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Brugia malayi	Heterochromatin protein 1	0.0061	0.0878	0.1282
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0037	0.0349	0.0229
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0144	0.2727	0.2559
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0037	0.0349	0.0126
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0226	0.1836
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.033
Brugia malayi	Heparan sulfate	0.0037	0.0349	0.051
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.017	0.3291	0.4807
Echinococcus multilocularis	hemicentin 1	0.0144	0.2727	0.2637
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0037	0.0349	0.051
Schistosoma mansoni	hypothetical protein	0.0133	0.247	0.2297
Schistosoma mansoni	hypothetical protein	0.026	0.5284	0.5175
Schistosoma mansoni	nephrin related	0.0037	0.0349	0.0126
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0037	0.0349	0.0229
Trypanosoma cruzi	hypothetical protein, conserved	0.0031	0.0226	0.1836
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0037	0.0349	0.0229
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0037	0.0349	0.0229
Loa Loa (eye worm)	immunoglobulin domain-containing protein	0.0037	0.0349	0.051
Schistosoma mansoni	septate junction protein	0.0037	0.0349	0.0126
Schistosoma mansoni	hypothetical protein	0.0037	0.0349	0.0126
Echinococcus multilocularis	geminin	0.026	0.5284	0.5225
Schistosoma mansoni	basigin related	0.0037	0.0349	0.0126
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0037	0.0349	0.0229
Echinococcus granulosus	netrin receptor unc 5	0.0037	0.0349	0.0229
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0037	0.0349	0.0229
Echinococcus granulosus	contactin	0.0144	0.2727	0.2637
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0037	0.0342	0.0848
Loa Loa (eye worm)	LAD-2 short isoform	0.0037	0.0349	0.051
Mycobacterium ulcerans	hypothetical protein	0.0031	0.0226	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0349	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	MH2 domain-containing protein	0.0093	0.1589	0.232
Trichomonas vaginalis	glutaminase, putative	0.033	0.6848	1
Echinococcus granulosus	hemicentin 1	0.0144	0.2727	0.2637
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0046	0.0556	0.0811
Mycobacterium ulcerans	glutaminase	0.033	0.6848	1
Echinococcus granulosus	3'partial\|cell adhesion molecule:down regulated by	0.0037	0.0349	0.0229
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0226	0.0238
Trypanosoma brucei	hypothetical protein, conserved	0.0031	0.0226	0.4062
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0046	0.0556	1
Echinococcus multilocularis	tyrosine protein kinase otk	0.0037	0.0349	0.0229
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0037	0.0349	0.0126
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0037	0.0349	0.0229
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0037	0.0349	0.0229
Echinococcus granulosus	peroxidasin	0.0037	0.0349	0.0229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.033
Schistosoma mansoni	hypothetical protein	0.0133	0.247	0.2297
Echinococcus multilocularis	roundabout 2	0.0037	0.0349	0.0229
Echinococcus granulosus	chromobox protein 1	0.0061	0.0878	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0285	0.0416
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0037	0.0349	0.0126
Echinococcus multilocularis	lachesin	0.0037	0.0349	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0046	0.0556	1
Schistosoma mansoni	basigin related	0.0037	0.0349	0.0126
Echinococcus granulosus	Immunoglobulin	0.0037	0.0349	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Mycobacterium ulcerans	lipase LipD	0.0031	0.0226	0.0111
Brugia malayi	Immunoglobulin domain containing protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	hypothetical protein	0.0144	0.2727	0.3983
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0349	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0121	0.0177
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	heterochromatin protein 1	0.0061	0.0878	0.1282
Echinococcus granulosus	roundabout 2	0.0037	0.0349	0.0229
Trichomonas vaginalis	penicillin-binding protein, putative	0.0031	0.0226	0.0238
Brugia malayi	beta-lactamase family protein	0.0031	0.0226	0.033
Brugia malayi	hypothetical protein	0.0277	0.5669	0.8279
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0285	0.0326
Schistosoma mansoni	hypothetical protein	0.0037	0.0349	0.0126
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0037	0.0349	0.0229
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0034	0.0285	0.0627
Schistosoma mansoni	chromobox protein	0.0061	0.0878	0.0667
Trypanosoma brucei	DNA polymerase IV, putative	0.0024	0.0051	0.0924
Trypanosoma brucei	DNA polymerase IV, putative	0.0028	0.0151	0.2726
Mycobacterium ulcerans	esterase/lipase LipP	0.0031	0.0226	0.0111
Onchocerca volvulus	Netrin receptor homolog	0.0107	0.1906	0.685
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0046	0.0556	1
Echinococcus multilocularis	peroxidasin	0.0037	0.0349	0.0229
Onchocerca volvulus		0.0107	0.1906	0.685
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.033
Loa Loa (eye worm)	transcription factor SMAD2	0.0093	0.1589	0.232
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0028	0.0151	0.0129
Brugia malayi	Peroxidasin	0.0037	0.0349	0.051
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0046	0.0556	0.0811
Mycobacterium ulcerans	beta-lactamase	0.0031	0.0226	0.0111
Echinococcus granulosus	neuroglian	0.0037	0.0349	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Echinococcus granulosus	roundabout 2	0.0037	0.0349	0.0229
Schistosoma mansoni	neuroglian	0.0037	0.0349	0.0126
Trichomonas vaginalis	DNA polymerase eta, putative	0.0028	0.0151	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Echinococcus granulosus	roundabout 2	0.0037	0.0349	0.0229
Echinococcus multilocularis	irregular chiasm roughest protein immunoglobulin set domain containing protein	0.0133	0.247	0.2377
Schistosoma mansoni	hypothetical protein	0.0037	0.0349	0.0126
Brugia malayi	chromobox protein homolog 3	0.0034	0.0285	0.0416
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0201	0.3984	1
Schistosoma mansoni	microtubule-associated protein tau	0.0472	1	1
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0037	0.0349	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Schistosoma mansoni	septate junction protein	0.0037	0.0349	0.0126
Schistosoma mansoni	hypothetical protein	0.0037	0.0349	0.0126
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0349	0.0126
Echinococcus granulosus	Immunoglobulin	0.0133	0.247	0.2377
Schistosoma mansoni	tyrosine kinase	0.0037	0.0349	0.0126
Echinococcus granulosus	tyrosine protein kinase otk	0.0037	0.0349	0.0229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Brugia malayi	beta-lactamase family protein	0.0031	0.0226	0.033
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Onchocerca volvulus		0.0031	0.0226	0.04
Brugia malayi	Immunoglobulin I-set domain containing protein	0.017	0.3291	0.4807
Brugia malayi	MH2 domain containing protein	0.0093	0.1589	0.232
Onchocerca volvulus		0.0031	0.0226	0.04
Echinococcus multilocularis	nephrin	0.0133	0.247	0.2377
Schistosoma mansoni	glutaminase	0.033	0.6848	0.6775
Echinococcus multilocularis	Immunoglobulin	0.0133	0.247	0.2377
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.033
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0107	0.1906	0.1805
Echinococcus granulosus	irregular chiasm roughest protein	0.0133	0.247	0.2377
Trypanosoma brucei	DNA polymerase IV, putative	0.0028	0.0151	0.2726
Mycobacterium leprae	conserved hypothetical protein	0.0031	0.0226	0.5
Echinococcus multilocularis	hemicentin 1	0.0037	0.0349	0.0229
Echinococcus multilocularis	chromobox protein 1	0.0061	0.0878	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Echinococcus granulosus	geminin	0.026	0.5284	0.5225
Brugia malayi	basement membrane proteoglycan	0.0037	0.0349	0.051
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0342	0.041
Brugia malayi	glutaminase DH11.1	0.033	0.6848	1
Brugia malayi	Prion-like-	0.0037	0.0349	0.051
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0144	0.2727	1
Echinococcus granulosus	chromobox protein 1	0.0061	0.0878	0.0764
Toxoplasma gondii	ABC1 family protein	0.0031	0.0226	0.5
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0037	0.0349	0.0126
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0226	0.5
Echinococcus multilocularis	roundabout 2	0.0037	0.0349	0.0229
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0349	0.0126
Echinococcus multilocularis	neuroglian	0.0037	0.0349	0.0229
Brugia malayi	beta-lactamase	0.0031	0.0226	0.033
Trichomonas vaginalis	chromobox protein, putative	0.0061	0.0878	0.12
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0031	0.0226	0.033
Echinococcus granulosus	Immunoglobulin subtype	0.0037	0.0349	0.0229
Onchocerca volvulus		0.0107	0.1906	0.685
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0046	0.0556	0.0438
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0037	0.0349	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Onchocerca volvulus		0.0107	0.1906	0.685
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Schistosoma mansoni	hypothetical protein	0.0037	0.0349	0.0126
Echinococcus multilocularis	dna polymerase kappa	0.0028	0.0151	0.0029
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.0037	0.0349	0.0229
Onchocerca volvulus		0.0031	0.0226	0.04
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Onchocerca volvulus	Tyrosine kinase homolog	0.0107	0.1906	0.685
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0285	0.0326
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0037	0.0349	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.033
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0349	0.0229
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0046	0.0556	0.0338
Trichomonas vaginalis	chromobox protein, putative	0.0061	0.0878	0.12
Schistosoma mansoni	titin	0.0144	0.2727	0.2559
Echinococcus granulosus	lachesin	0.0037	0.0349	0.0229
Trypanosoma brucei	DNA polymerase kappa, putative	0.0028	0.0151	0.2726
Loa Loa (eye worm)	beta-lactamase	0.0031	0.0226	0.033
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0046	0.0556	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0226	0.033
Schistosoma mansoni	septate junction protein	0.0037	0.0349	0.0126
Echinococcus multilocularis	roundabout 2	0.0037	0.0349	0.0229
Loa Loa (eye worm)	glutaminase	0.033	0.6848	1
Echinococcus granulosus	dna polymerase kappa	0.0028	0.0151	0.0029
Echinococcus multilocularis	conserved hypothetical protein	0.0133	0.247	0.2377
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0037	0.0349	0.051
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0226	0.0238
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0349	0.0126
Schistosoma mansoni	basigin related	0.0037	0.0349	0.0126
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0037	0.0349	0.0229
Mycobacterium leprae	Probable lipase LipE	0.0031	0.0226	0.5
Echinococcus multilocularis	chromobox protein 1	0.0061	0.0878	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Echinococcus granulosus	nephrin	0.0133	0.247	0.2377
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0037	0.0349	0.051
Echinococcus granulosus	beta LACTamase domain containing family member	0.0031	0.0226	0.0104
Schistosoma mansoni	cell adhesion molecule	0.0037	0.0349	0.0126
Schistosoma mansoni	nephrin	0.0037	0.0349	0.0126
Schistosoma mansoni	chromobox protein	0.0061	0.0878	0.0667
Echinococcus multilocularis	Immunoglobulin subtype	0.0037	0.0349	0.0229
Trichomonas vaginalis	chromobox protein, putative	0.0037	0.0342	0.041
Schistosoma mansoni	hypothetical protein	0.0037	0.0349	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0349	0.051
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0046	0.0556	1
Onchocerca volvulus	Putative titin	0.0107	0.1906	0.685
Echinococcus multilocularis	microtubule associated protein 2	0.0472	1	1
Trichomonas vaginalis	esterase, putative	0.0031	0.0226	0.0238
Brugia malayi	Immunoglobulin domain containing protein	0.0037	0.0349	0.051
Schistosoma mansoni	netrin receptor unc5	0.0037	0.0349	0.0126
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0349	0.051
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0037	0.0349	0.0126
Trichomonas vaginalis	D-aminoacylase, putative	0.0031	0.0226	0.0238
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0046	0.0556	0.0438

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3497385

Bibliographic References

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Detailed information for compound 2072088