Detailed information for compound 208638

Basic information

Technical information
  • TDR Targets ID: 208638
  • Name: 4-[(4-cyanobenzoyl)amino]phthalic acid
  • MW: 310.261 | Formula: C16H10N2O5
  • H donors: 3 H acceptors: 6 LogP: 1.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C(=O)Nc1ccc(c(c1)C(=O)O)C(=O)O
  • InChi: 1S/C16H10N2O5/c17-8-9-1-3-10(4-2-9)14(19)18-11-5-6-12(15(20)21)13(7-11)16(22)23/h1-7H,(H,18,19)(H,20,21)(H,22,23)
  • InChiKey: FGCVPJXSXRZYPA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[[(4-cyanophenyl)-oxomethyl]amino]phthalic acid
  • 4-[(4-cyanophenyl)carbonylamino]phthalic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.006 0.0613
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.006 0.0477
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0348 0.0963
Brugia malayi nuclear hormone receptor 0.001 0.0014 0.0036
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0533 0.1384
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0056 0.021
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0111 0.0874
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.006 0.0149
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0194 0.197
Schistosoma mansoni hypothetical protein 0.0026 0.0223 0.0263
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.006 0.0477
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0914
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.001 0.0013 0.0106
Loa Loa (eye worm) hypothetical protein 0.0232 0.2837 0.7365
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1642 0.1934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0082 0.0213
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0111 0.013
Echinococcus granulosus expressed conserved protein 0.0091 0.1041 0.1226
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0348 0.0963
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Schistosoma mansoni survival motor neuron protein 0.0047 0.0489 0.0576
Toxoplasma gondii propionate-CoA ligase 0.0014 0.006 0.0613
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0466
Toxoplasma gondii ATPase, AAA family protein 0.0019 0.0132 0.134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0669 0.0787
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0339 0.0935
Schistosoma mansoni nuclear hormone receptor 0.001 0.0014 0.0016
Echinococcus granulosus dnaJ subfamily B 0.0396 0.4929 0.5804
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0339 0.0935
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0559 0.7006 0.8249
Echinococcus granulosus twitchin 0.0016 0.0087 0.0103
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.006 0.0477
Schistosoma mansoni hypothetical protein 0.008 0.0909 0.1071
Onchocerca volvulus Huntingtin homolog 0.012 0.1416 0.7035
Echinococcus multilocularis nibrin 0.0019 0.0132 0.0132
Trypanosoma brucei metacaspase 5, putative 0.0086 0.0985 0.7771
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.012 0.1214
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Brugia malayi steroid hormone receptor 0.001 0.0014 0.0036
Echinococcus multilocularis Immunoglobulin 0.0016 0.0087 0.0087
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0228 0.2788 0.2788
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.006 0.0477
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.012 0.031
Schistosoma mansoni vesicular amine transporter 0.0016 0.0087 0.0103
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0108 0.1267 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0223 0.058
Trypanosoma cruzi metacaspase 5, putative 0.0086 0.0985 0.7771
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.349 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0014 0.0016
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0476 0.2616
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Loa Loa (eye worm) hypothetical protein 0.012 0.1416 0.3675
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.006 0.0071
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.012 0.0141
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.0985 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0151 0.1192
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0056 0.0145
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0132 0.0341
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0014
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0014 0.006 0.0135
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0056 0.044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Trypanosoma brucei hypothetical protein 0.0108 0.1267 1
Echinococcus multilocularis dnaJ subfamily B 0.0396 0.4929 0.4929
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0331 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0036
Schistosoma mansoni cell adhesion molecule 0.0016 0.0087 0.0103
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0111 0.0874
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0331 0.039
Brugia malayi RNA binding protein 0.0061 0.0669 0.1736
Echinococcus granulosus tumor protein p63 0.0327 0.4052 0.4771
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.006 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0036
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0056 0.044
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0669 0.1736
Schistosoma mansoni alpha-glucosidase 0.0137 0.1637 0.1927
Onchocerca volvulus Huntingtin homolog 0.012 0.1416 0.7035
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0016 0.0087 0.0103
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0476 0.2726
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0011 0.0028 0.0283
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0014 0.0016
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0056 0.0121
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0056 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0476 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0111 0.0874
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0019 0.0132 0.0341
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.006 0.0149
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0497 0.0586
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1116 0.1116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0108 0.1267 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0108 0.1267 1
Echinococcus multilocularis tumor protein p63 0.0327 0.4052 0.4052
Trypanosoma cruzi FHA domain containing protein, putative 0.0019 0.0132 0.1041
Echinococcus multilocularis cpg binding protein 0.0029 0.0262 0.0262
Loa Loa (eye worm) hypothetical protein 0.0096 0.1116 0.2896
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0639 0.0752
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0476 0.2616
Trypanosoma brucei Metacaspase-4 0.0086 0.0985 0.7771
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0327 0.1804
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0132 0.1041
Trypanosoma cruzi metacaspase, putative 0.0086 0.0985 0.7771
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0415 0.0415
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.012 0.0516
Schistosoma mansoni topbp1 0.0019 0.0132 0.0155
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1116 0.1313
Loa Loa (eye worm) hypothetical protein 0.0166 0.2006 0.5209
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0339 0.0935
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0849
Mycobacterium ulcerans hypothetical protein 0.0046 0.0476 0.2616
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0489 0.127
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0132 0.0341
Loa Loa (eye worm) hypothetical protein 0.0046 0.0476 0.1235
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0985 0.2793
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0303 0.1655
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0476 0.2616
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1135 0.1336
Trypanosoma cruzi metacaspase, putative 0.0086 0.0985 0.7771
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0019 0.0132 0.1041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0341
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0014 0.0016
Trypanosoma brucei metacaspase MCA2 0.0086 0.0985 0.7771
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0476 0.1329
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0056 0.0121
Onchocerca volvulus 0.0046 0.0476 0.2318
Schistosoma mansoni hypothetical protein 0.0035 0.0331 0.039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.012 0.0944
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0082 0.0082
Brugia malayi topoisomerase 0.0019 0.0132 0.0342
Onchocerca volvulus 0.0048 0.0497 0.2427
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0108 0.1267 1
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0327 0.3321
Schistosoma mansoni inositol monophosphatase 0.0036 0.0348 0.041
Echinococcus multilocularis caspase 2 0.0166 0.2006 0.2006
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0014 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0476 0.3754
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0087 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Echinococcus granulosus geminin 0.033 0.4089 0.4815
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.349 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1116 0.317
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0985 0.2793
Schistosoma mansoni caspase-7 (C14 family) 0.0166 0.2006 0.2362
Brugia malayi TAR-binding protein 0.0061 0.0669 0.1736
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0111 0.0874
Echinococcus granulosus replication factor c subunit 1 0.0019 0.0132 0.0155
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0036
Brugia malayi Cell death protein 3 precursor 0.0166 0.2006 0.5209
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0348 0.2749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0194 0.0519
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0339 0.2672
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.006 0.0135
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0476 0.2616
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0194 0.0228
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.012 0.0944
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1919 0.1919
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0036
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0111 0.028
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.8493 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0108 0.1267 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.006 0.0477
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0476 0.1235
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0111 0.0874
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0111 0.0874
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0669 0.1736
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0111 0.1124
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0327 0.168
Giardia lamblia Replication factor C, subunit 1 0.0019 0.0132 0.0063
Echinococcus granulosus protein quaking 0.0026 0.0223 0.0263
Trypanosoma cruzi metacaspase, putative 0.0086 0.0985 0.7771
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0327 0.3321
Echinococcus granulosus serine:threonine protein kinase SMG1 0.001 0.0013 0.0016
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.006 0.0613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0242 0.0628
Trypanosoma brucei glucosidase, putative 0.0035 0.0339 0.2672
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.006 0.0149
Echinococcus multilocularis protein patched 0.0041 0.0415 0.0415
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0082 0.0097
Brugia malayi hypothetical protein 0.008 0.0909 0.2361
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0036
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0348 0.3538
Brugia malayi hypothetical protein 0.0232 0.2837 0.7365
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0341
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.006 0.0149
Schistosoma mansoni hypothetical protein 0.033 0.4089 0.4815
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0339 0.0935
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.0799
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0014 0.0036
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0056 0.044
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0914
Loa Loa (eye worm) hypothetical protein 0.0011 0.0028 0.0072
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0194 0.1531
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0348 0.0963
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0056 0.0121
Brugia malayi nuclear receptor NHR-88 0.001 0.0014 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0014 0.0036
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0056 0.044
Brugia malayi ecdysteroid receptor 0.001 0.0014 0.0036
Echinococcus granulosus hypothetical protein 0.0026 0.0223 0.0263
Onchocerca volvulus 0.0028 0.0242 0.1144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0111 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0342
Echinococcus granulosus FTZ F1 alpha 0.001 0.0014 0.0016
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.012 0.0026
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0111 0.013
Schistosoma mansoni caspase-7 (C14 family) 0.0228 0.2788 0.3282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0019 0.0132 0.0342
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1919 0.4984
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0014 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0348 0.2749
Brugia malayi AMP-binding enzyme family protein 0.0014 0.006 0.0157
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.006 0.0477
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Echinococcus multilocularis expressed conserved protein 0.0091 0.1041 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0985 0.2793
Loa Loa (eye worm) hypothetical protein 0.0086 0.0985 0.2556
Trypanosoma brucei calpain, putative 0.0108 0.1267 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.012 0.0944
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0014 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0056 0.0121
Toxoplasma gondii exonuclease III APE 0.0018 0.012 0.1214
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0111 0.0287
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.012 0.0305
Echinococcus granulosus caspase 3 0.0142 0.1691 0.1991
Echinococcus granulosus microtubule associated protein 2 0.0676 0.8493 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.006 0.0157
Schistosoma mansoni cpg binding protein 0.0028 0.0242 0.0285
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0914
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0476 0.1329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0339 0.0935
Loa Loa (eye worm) tumor suppressor 0.0311 0.3851 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0019 0.0132 0.0341
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0056 0.0121
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.012 0.031
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1919 0.4984
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0339 0.0935
Brugia malayi tumor suppressor. 0.0311 0.3851 1
Brugia malayi Fibronectin type III domain containing protein 0.0016 0.0087 0.0226
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0056 0.0121
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0303 0.1655
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.006 0.006
Leishmania major metacaspase, putative 0.0086 0.0985 0.7771
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Onchocerca volvulus 0.0019 0.0132 0.0593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0019 0.0132 0.0451
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0194 0.0228
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0014 0.0036
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0014 0.0036
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Plasmodium falciparum metacaspase-like protein 0.0086 0.0985 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0339 0.2672
Onchocerca volvulus 0.0014 0.006 0.0234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0502 0.1304
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0108 0.1267 1
Echinococcus granulosus defective proboscis extension response 0.0016 0.0087 0.0103
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Echinococcus granulosus tar DNA binding protein 0.0061 0.0669 0.0787
Schistosoma mansoni nephrin 0.0016 0.0087 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0036
Echinococcus granulosus cpg binding protein 0.0029 0.0262 0.0308
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0849
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.0213
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.012 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0341
Echinococcus multilocularis GPCR, family 2 0.0015 0.0082 0.0082
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1919 0.1919
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0011 0.0028 0.022
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0669 0.0787
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0502 0.1304
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.03 0.1637
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1642 0.1642
Loa Loa (eye worm) RNA binding protein 0.0061 0.0669 0.1736
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0036
Echinococcus granulosus roundabout 2 0.0016 0.0087 0.0103
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0348 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Schistosoma mansoni ap endonuclease 0.0018 0.012 0.0141
Schistosoma mansoni cpg binding protein 0.0029 0.0262 0.0308
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0362
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0132 0.0341
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0111 0.0287
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0339 0.0879
Schistosoma mansoni ap endonuclease 0.0018 0.012 0.0141
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.006 0.0613
Echinococcus multilocularis roundabout 2 0.0016 0.0087 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0036
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0111 0.0877
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0016 0.0087 0.0087
Echinococcus multilocularis geminin 0.033 0.4089 0.4089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0111 0.0287
Loa Loa (eye worm) hypothetical protein 0.008 0.0909 0.2361
Plasmodium falciparum replication factor C subunit 1, putative 0.0019 0.0132 0.134
Echinococcus granulosus Immunoglobulin 0.0016 0.0087 0.0103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0502 0.1304
Echinococcus multilocularis protein quaking 0.0026 0.0223 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0056 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0036
Plasmodium vivax metacaspase 1, putative 0.0086 0.0985 1
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0348 0.041
Schistosoma mansoni hypothetical protein 0.0015 0.0082 0.0097
Loa Loa (eye worm) inositol-1 0.0036 0.0348 0.0905
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0669 0.0669
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0036
Schistosoma mansoni alpha glucosidase 0.0035 0.0339 0.0399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Schistosoma mansoni coup transcription factor 0.001 0.0014 0.0016
Onchocerca volvulus Cell death protein 3 homolog 0.0166 0.2006 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0111 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0036
Brugia malayi hypothetical protein 0.0019 0.0132 0.0342
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0048 0.0497 0.1291
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0476 0.2616
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0339 0.0935
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0342
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0132 0.1041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.012 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0415 0.1154
Schistosoma mansoni topbp1 0.0019 0.0132 0.0155
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0014 0.0016
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0014 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0303 0.1655
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0111 0.0874
Echinococcus multilocularis caspase 8 0.0086 0.0985 0.0985
Brugia malayi DKFZp564C0469 protein 0.0019 0.0132 0.0342
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.0046 0.0476 0.1235
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2837 0.2837
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0111 0.0874
Brugia malayi AMP-binding enzyme family protein 0.0014 0.006 0.0157
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0476 0.2616
Onchocerca volvulus 0.0047 0.0489 0.2386
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0014 0.0036
Plasmodium vivax replication factor C subunit 1, putative 0.0019 0.0132 0.134
Schistosoma mansoni DNA ligase IV 0.0019 0.0132 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0348 0.1815
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0327 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0105 0.0273
Echinococcus granulosus caspase 8 0.0086 0.0985 0.1159
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0111 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Entamoeba histolytica hypothetical protein 0.0019 0.0132 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0016 0.0087 0.0103
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0014 0.0014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0194 0.0504
Loa Loa (eye worm) hypothetical protein 0.0048 0.0502 0.1304
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0476 0.2616
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0014 0.0014
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2837 0.334
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.0985 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0415 0.0488
Plasmodium falciparum metacaspase 1 0.0086 0.0985 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0342
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0014 0.0016
Schistosoma mansoni caspase-3 (C14 family) 0.0228 0.2788 0.3282
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0985 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0339 0.0935
Trypanosoma brucei metacaspase MCA3 0.0086 0.0985 0.7771
Trypanosoma brucei calpain-like protein, putative 0.0108 0.1267 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.006 0.0149
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0242 0.0628
Echinococcus granulosus caspase 0.0228 0.2788 0.3282
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1648 1
Trypanosoma brucei metacaspase 0.0086 0.0985 0.7771
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0111 0.028
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0339 0.0935
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0082 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0342
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1648 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0111 0.0874
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1116 0.2896
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0342
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.006 0.0157
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0194 0.1531
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0849
Loa Loa (eye worm) hypothetical protein 0.0021 0.0151 0.0392
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.012 0.0944
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0342
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.006 0.0157
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Echinococcus multilocularis protein dispatched 1 0.0047 0.0489 0.0489
Brugia malayi hypothetical protein 0.0019 0.0132 0.0342
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0466
Loa Loa (eye worm) hypothetical protein 0.0041 0.0415 0.1077
Schistosoma mansoni hypothetical protein 0.0015 0.0082 0.0097
Brugia malayi hypothetical protein 0.0016 0.0087 0.0226
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0339 0.0399
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0111 0.013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0036
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0111 0.0877
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0157
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0303 0.1655
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.001 0.0013 0.0035
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0111 0.0874
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.006 0.0157
Brugia malayi hypothetical protein 0.0035 0.0331 0.086
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.006 0.0613
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.006 0.0071
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0056 0.0121
Schistosoma mansoni thyroid hormone receptor 0.001 0.0014 0.0016
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0476 0.1329
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0348 0.2749
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0339 0.0879
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0849
Echinococcus multilocularis replication factor c subunit 1 0.0019 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.001 0.0013 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0985 0.2793
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.349 1
Brugia malayi AMP-binding enzyme family protein 0.0014 0.006 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0476 0.3754
Echinococcus multilocularis Immunoglobulin 0.0016 0.0087 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0476 0.2616
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0108 0.1267 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0669 0.1736
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.006 0.0477
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0339 0.0935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0111 0.0874
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0466
Echinococcus granulosus neuroglian 0.0016 0.0087 0.0103
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.006 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0476 0.1235
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0086 0.0985 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0014 0.0014
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.006 0.0149
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.349 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0082 0.0213
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0111 0.0874
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.012 0.1214
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.012 0.0305
Loa Loa (eye worm) hypothetical protein 0.0046 0.0476 0.1235
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0476 0.3754
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0019 0.0132 0.0451
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0111 0.0287
Brugia malayi Inositol-1 0.0036 0.0348 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1919 0.226
Schistosoma mansoni hypothetical protein 0.0047 0.0489 0.0576
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0348 0.2749
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0415 0.1077
Trypanosoma cruzi metacaspase 5, putative 0.0086 0.0985 0.7771
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0111 0.0874
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0014 0.0016
Echinococcus multilocularis apoptotic protease activating factor 1 0.008 0.0909 0.0909
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0339 0.0935
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0669 0.0787
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.006 0.0135
Entamoeba histolytica hypothetical protein 0.0035 0.0331 0.0914
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.001 0.0013 0.0013
Schistosoma mansoni inositol monophosphatase 0.0036 0.0348 0.041
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.006 0.0149
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0308 0.0799
Onchocerca volvulus 0.008 0.0909 0.4495
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0415 0.0488
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0019 0.0132 0.0538
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Brugia malayi Temporarily assigned gene name protein 44 0.0026 0.0223 0.058
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0014 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.006 0.0149
Brugia malayi AMP-binding enzyme family protein 0.0014 0.006 0.0157
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0111 0.0874
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0132 0.1041
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0669 0.0787
Loa Loa (eye worm) hypothetical protein 0.0014 0.006 0.0157
Echinococcus granulosus caspase 2 0.0166 0.2006 0.2362
Treponema pallidum DNA ligase (lig) 0.0019 0.0132 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0036
Onchocerca volvulus 0.0092 0.1063 0.5265
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0016 0.0087 0.0103
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.03 0.151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0014 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0985 0.2793
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0111 0.0111
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0339 0.3439
Brugia malayi Pax transcription activation domain interacting protein 0.0019 0.0132 0.0342
Onchocerca volvulus 0.0014 0.006 0.0234
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0036
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.006 0.0477
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0985 0.2793
Loa Loa (eye worm) hypothetical protein 0.0016 0.0087 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0028 0.0041
Brugia malayi hypothetical protein 0.012 0.1416 0.3675
Brugia malayi hypothetical protein 0.0026 0.0223 0.058
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0228 0.2788 0.3282
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.8493 0.8493
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0348 0.0348
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0339 0.0339
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0019 0.0132 0.0341
Schistosoma mansoni cpg binding protein 0.0029 0.0262 0.0308
Echinococcus multilocularis caspase 3 0.0142 0.1691 0.1691
Echinococcus multilocularis caspase 0.0228 0.2788 0.2788
Schistosoma mansoni hypothetical protein 0.0026 0.0223 0.0263
Schistosoma mansoni hypothetical protein 0.033 0.4089 0.4815
Schistosoma mansoni chromosome transmission fidelity factor 0.0019 0.0132 0.0155
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0105 0.0273
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.006 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0014 0.0014
Onchocerca volvulus 0.0014 0.006 0.0234
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0558 0.5671
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0082 0.0097
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0019 0.0132 0.1339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Echinococcus granulosus GPCR family 2 0.0015 0.0082 0.0097
Schistosoma mansoni hypothetical protein 0.0015 0.0082 0.0097
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0348 0.0963
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0086 0.0985 0.1159
Schistosoma mansoni hypothetical protein 0.0015 0.0082 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Schistosoma mansoni hypothetical protein 0.004 0.0396 0.0466
Brugia malayi CHE-14 protein 0.0041 0.0415 0.1077
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0108 0.1267 1
Loa Loa (eye worm) oxidoreductase 0.0014 0.006 0.0157
Entamoeba histolytica hypothetical protein 0.0024 0.0194 0.0519
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0476 0.2616
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0194 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0028 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0014 0.0036
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0339 0.2672
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0086 0.0985 0.2793
Schistosoma mansoni fkbp-rapamycin associated protein 0.001 0.0013 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Schistosoma mansoni hypothetical protein 0.0396 0.4929 0.5804
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0111 0.028
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0014 0.0014
Echinococcus granulosus nibrin 0.0019 0.0132 0.0155
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0086 0.0985 0.2556
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.006 0.0149
Trichomonas vaginalis replication factor C large subunit, putative 0.0019 0.0132 0.0341
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0669 0.0787
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.012 0.012
Schistosoma mansoni patched 1 0.0041 0.0415 0.0488
Schistosoma mansoni alpha-glucosidase 0.0137 0.1637 0.1927
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1648 1
Trypanosoma cruzi metacaspase, putative 0.0086 0.0985 0.7771
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0014 0.0014
Onchocerca volvulus 0.0014 0.006 0.0234
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0476 0.2726
Loa Loa (eye worm) hypothetical protein 0.012 0.1416 0.3675
Echinococcus multilocularis neuroglian 0.0016 0.0087 0.0087
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0056 0.0121
Echinococcus granulosus apoptotic protease activating factor 1 0.008 0.0909 0.1071

Activities

Activity type Activity value Assay description Source Reference
ID50 (functional) NA 0 mg kg-1 Cytoprotective activity against ethanol-induced gastric lesions in male conscious rats; Inactive. ChEMBL. 1433173
ID50 (functional) = 10.1 mg kg-1 Antiallergic activity against rat passive cutaneous anaphylaxis (PCA) reaction induced by 25 mg/kg of ovalbumin given iv (bolus). ChEMBL. 1433173

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.