Detailed information for compound 209714

Basic information

Technical information
  • TDR Targets ID: 209714
  • Name: 1-[(E)-3-[4-[[2-[4-(2-pyrrolidin-1-ylethoxy)p henyl]-1-benzothiophen-3-yl]methyl]phenyl]pro p-2-enyl]pyrrolidine
  • MW: 522.743 | Formula: C34H38N2OS
  • H donors: 0 H acceptors: 0 LogP: 7.99 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: C1CCN(C1)CCOc1ccc(cc1)c1sc2c(c1Cc1ccc(cc1)/C=C/CN1CCCC1)cccc2
  • InChi: 1S/C34H38N2OS/c1-2-10-33-31(9-1)32(26-28-13-11-27(12-14-28)8-7-23-35-19-3-4-20-35)34(38-33)29-15-17-30(18-16-29)37-25-24-36-21-5-6-22-36/h1-2,7-18H,3-6,19-26H2/b8-7+
  • InChiKey: AVIGKYPXNRJZJA-BQYQJAHWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[(E)-3-[4-[[2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]benzothiophen-3-yl]methyl]phenyl]allyl]pyrrolidine
  • 1-[(E)-3-[4-[[2-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-3-benzothiophenyl]methyl]phenyl]allyl]pyrrolidine
  • 1-[(E)-3-[4-[[2-[4-(2-pyrrolidinoethoxy)phenyl]benzothiophen-3-yl]methyl]phenyl]allyl]pyrrolidine
  • 1-[2-[4-[3-[[4-[(E)-3-pyrrolidin-1-ylprop-1-enyl]phenyl]methyl]-1-benzothiophen-2-yl]phenoxy]ethyl]pyrrolidine
  • 1-[2-[4-[3-[[4-[(E)-3-pyrrolidin-1-ylprop-1-enyl]phenyl]methyl]benzothiophen-2-yl]phenoxy]ethyl]pyrrolidine
  • 1-[2-[4-[3-[[4-[(E)-3-1-pyrrolidinylprop-1-enyl]phenyl]methyl]-2-benzothiophenyl]phenoxy]ethyl]pyrrolidine
  • 1-[2-[4-[3-[4-[(E)-3-pyrrolidin-1-ylprop-1-enyl]benzyl]benzothiophen-2-yl]phenoxy]ethyl]pyrrolidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0684 0.0654
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0848 0.0846
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.0067 0.0064
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.1409 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0033 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0322 0.032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0033 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Schistosoma mansoni polycystin 1-related 0.0019 0.0233 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0033 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0684 0.0682
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0322 0.0322
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0322 0.0291
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.002 0.0243 0.1369
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0322 0.0291
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.0684
Schistosoma mansoni glutamate receptor NMDA 0.0012 0.0067 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0033 0.0033
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0234 0.4942 0.4941
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0233 0.0231
Echinococcus granulosus GPCR family 2 0.0031 0.0501 0.0499
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0058 0.0058
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0033 0.0033
Loa Loa (eye worm) inositol-1 0.0073 0.1409 0.1407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0033 0.0033
Onchocerca volvulus 0.0023 0.0322 0.0291
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0308 0.6552 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0322 0.0291
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0233 0.0231
Brugia malayi mbt repeat family protein 0.0047 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Plasmodium falciparum glutathione reductase 0.0042 0.0734 0.2803
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0322 0.032
Schistosoma mansoni loxhd1 0.0019 0.0233 0.0201
Echinococcus granulosus fmrfamide receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0322 0.032
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0011 0.0058 0.0058
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0322 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1145 0.8043
Treponema pallidum sodium- and chloride- dependent transporter 0.0234 0.4942 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0991 0.0962
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0322 0.032
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.8517 0.8516
Echinococcus multilocularis serotonin receptor 0.0023 0.0322 0.032
Echinococcus granulosus glutamate synthase 0.0011 0.0058 0.0055
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0322 0.032
Brugia malayi RE15519p 0.0023 0.0322 0.0322
Echinococcus granulosus thioredoxin glutathione reductase 0.0122 0.2493 0.2491
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0322 0.0322
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0042 0.0734 0.0704
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1988 0.1988
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.5365 0.5364
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.002 0.0243 0.0379
Echinococcus multilocularis GPCR, family 2 0.0031 0.0501 0.0499
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0058 0.0055
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0277 0.5875 0.8958
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0012 0.0067 0.0064
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0322 0.032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) programmed cell death 8 0.0011 0.0058 0.0055
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0011 0.0058 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0033 0.0033
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0684 0.0654
Schistosoma mansoni hypothetical protein 0.0031 0.0501 0.047
Brugia malayi glutathione reductase 0.0121 0.2471 0.2471
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Plasmodium falciparum glutathione reductase 0.0121 0.2471 1
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0011 0.0058 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0322 0.032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0277 0.5875 0.8958
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0233 0.0231
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1145 0.1142
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.1409 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0991 0.0991
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0848 0.0818
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Brugia malayi steroid hormone receptor 0.001 0.0033 0.0033
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0322 0.032
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0322 0.032
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.0067 0.0064
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.2595
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0308 0.6552 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1988 0.1988
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0684 0.0682
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1145 0.1673
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0042 0.0734 0.0835
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0011 0.0058 0.0055
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Onchocerca volvulus 0.0019 0.0233 0.0201
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.3891 0.3889
Schistosoma mansoni neuropeptide receptor 0.0023 0.0322 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Schistosoma mansoni glutamate synthase 0.0011 0.0058 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0011 0.0058 0.0055
Echinococcus multilocularis RUN 0.0019 0.0233 0.0231
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0848 0.0818
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0684 0.0682
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0033 0.003
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0465 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1409 0.1668
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0322 0.032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0322 0.0291
Schistosoma mansoni amine GPCR 0.0023 0.0322 0.0291
Schistosoma mansoni hypothetical protein 0.0031 0.0501 0.047
Loa Loa (eye worm) glutathione reductase 0.0121 0.2471 0.2469
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Schistosoma mansoni hypothetical protein 0.0023 0.0322 0.0291
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0322 0.032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0322 0.0322
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0322 0.032
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0233 0.0231
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0848 0.0818
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus somatostatin receptor 0.0023 0.0322 0.032
Echinococcus granulosus cpg binding protein 0.003 0.0459 0.0457
Schistosoma mansoni amine GPCR 0.0023 0.0322 0.0291
Brugia malayi nuclear receptor NHR-88 0.001 0.0033 0.0033
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0042 0.0734 0.5006
Trichomonas vaginalis glutathione reductase, putative 0.0042 0.0734 0.5006
Echinococcus granulosus RUN 0.0019 0.0233 0.0231
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0047 0.0848 0.0846
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0991 0.0989
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0684 0.0684
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0031 0.049 0.049
Brugia malayi sulfakinin receptor protein 0.0023 0.0322 0.0322
Brugia malayi Doublecortin family protein 0.0019 0.0233 0.0233
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0322 0.032
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Schistosoma mansoni glutamate synthase 0.0011 0.0058 0.0025
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Thioredoxin reductase 0.0121 0.2471 0.2471
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0042 0.0734 0.0732
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Onchocerca volvulus 0.0023 0.0322 0.0291
Onchocerca volvulus 0.0023 0.0322 0.0291
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0684 0.0654
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0684 0.0682
Echinococcus multilocularis cpg binding protein 0.003 0.0459 0.0457
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0424 0.0422
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.1409 1
Schistosoma mansoni biogenic amine receptor 0.0023 0.0322 0.0291
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0322 0.032
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0322 0.032
Onchocerca volvulus 0.0019 0.0233 0.0201
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.0322 0.032
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0322 0.032
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0042 0.0734 0.0835
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0322 0.0291
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0322 0.032
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0042 0.0734 0.0732
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0033 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0033 0.003
Echinococcus granulosus vesicular acetylcholine transporter 0.0465 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.0684
Echinococcus granulosus serotonin receptor 0.0023 0.0322 0.032
Schistosoma mansoni biogenic amine receptor 0.0023 0.0322 0.0291
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0322 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0068 0.13 0.1298
Schistosoma mansoni opsin-like receptor 0.0023 0.0322 0.0291
Brugia malayi neuropeptide F receptor 0.0023 0.0322 0.0322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0501 0.0499
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0011 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0086 0.1706 0.1704
Loa Loa (eye worm) norepinephrine transporter 0.0234 0.4942 0.4941
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0848 0.0846
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0322 0.032
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.0684
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0308 0.6552 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0816 0.0816
Brugia malayi hypothetical protein 0.004 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0684 0.0682
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.2323 0.2321
Onchocerca volvulus 0.0023 0.0322 0.0291
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1145 0.8043
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.2595
Schistosoma mansoni adenoreceptor 0.0023 0.0322 0.0291
Mycobacterium tuberculosis Probable reductase 0.0277 0.5875 0.8958
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0322 0.032
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0322 0.0291
Onchocerca volvulus 0.0234 0.4942 0.4926
Trichomonas vaginalis mercuric reductase, putative 0.0042 0.0734 0.5006
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.0067 0.0064
Brugia malayi Dopamine receptor protein 1 0.0023 0.0322 0.0322
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0195 0.4078 0.4077
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0684 0.0682
Onchocerca volvulus 0.004 0.0684 0.0654
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0322 0.032
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0322 0.0291
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0322 0.0291
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0322 0.032
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0042 0.0734 0.0835
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.1409 0.56
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0322 0.032
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0011 0.0058 0.0055
Schistosoma mansoni hypothetical protein 0.0011 0.0058 0.0025
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0322 0.0291
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0848 0.0846
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.2595
Trypanosoma cruzi trypanothione reductase, putative 0.0121 0.2471 0.2979
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Brugia malayi glutamate synthase 0.0011 0.0058 0.0058
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0322 0.032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0816 0.0786
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0322 0.032
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0058 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0816 0.0786
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.0682
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0322 0.0291
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1409 0.1668
Brugia malayi hypothetical protein 0.0019 0.0233 0.0233
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0322 0.032
Brugia malayi G-protein coupled receptor 0.0023 0.0322 0.0322
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0501 0.0501
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0501 0.0499
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0011 0.0058 0.0055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1409 0.1668
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0322 0.032
Schistosoma mansoni hypothetical protein 0.0031 0.0501 0.047
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Onchocerca volvulus 0.0023 0.0322 0.0291
Plasmodium vivax thioredoxin reductase, putative 0.0121 0.2471 1
Schistosoma mansoni hypothetical protein 0.0031 0.0501 0.047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0684 0.0654
Echinococcus multilocularis vesicular acetylcholine transporter 0.0465 1 1
Echinococcus granulosus sex peptide receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi hypothetical protein 0.0086 0.1706 0.1706
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0033 0.003
Mycobacterium tuberculosis Probable dehydrogenase 0.0277 0.5875 0.8958
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0684 0.0682
Schistosoma mansoni opsin-like receptor 0.0023 0.0322 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0033 0.0033
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.3891 0.3889
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0277 0.5875 0.8958
Onchocerca volvulus 0.0023 0.0322 0.0291
Onchocerca volvulus 0.004 0.0684 0.0654
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0277 0.5875 0.8958
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0322 0.0291
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0501 0.0499
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.0734 0.5006
Brugia malayi Inositol-1 0.0073 0.1409 0.1409
Echinococcus granulosus g protein coupled receptor 0.0023 0.0322 0.032
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0816 0.0786
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0233 0.0231
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0033 0.003
Toxoplasma gondii thioredoxin reductase 0.0121 0.2471 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0233 0.0726
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0033 0.003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0042 0.0734 0.0734
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0033 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0033 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0322 0.0291
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0684 0.0654
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0991 0.0989
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0734 0.0835
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi AKH receptor 0.0023 0.0322 0.0322
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0322 0.0291
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1145 0.4504
Loa Loa (eye worm) hypothetical protein 0.0086 0.1706 0.1704
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0465 1 1
Brugia malayi hypothetical protein 0.0019 0.0233 0.0233
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.1409 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0501 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Brugia malayi ORL1-like opioid receptor 0.0023 0.0322 0.0322
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0033 0.0033
Schistosoma mansoni neuropeptide receptor 0.0023 0.0322 0.0291
Schistosoma mansoni rab6-interacting 0.0019 0.0233 0.0201
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus multilocularis sex peptide receptor 0.0023 0.0322 0.032
Echinococcus granulosus neuropeptide receptor 0.0023 0.0322 0.032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0033 0.0033
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0684 0.0654
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0816 0.0814
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0042 0.0734 0.2803
Plasmodium falciparum transporter, putative 0.004 0.0684 0.2595
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0033 0.003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0012 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus multilocularis somatostatin receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Dopamine receptor 0.0023 0.0322 0.0322
Toxoplasma gondii hypothetical protein 0.004 0.0684 0.2595
Brugia malayi CXXC zinc finger family protein 0.0028 0.0424 0.0424
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0033 0.0033
Echinococcus granulosus FTZ F1 alpha 0.001 0.0033 0.003
Brugia malayi ecdysteroid receptor 0.001 0.0033 0.0033
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0322 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0322 0.032
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.1409 0.1407
Onchocerca volvulus 0.0011 0.0058 0.0025
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0684 0.0654
Schistosoma mansoni disulfide oxidoreductase 0.0011 0.0058 0.0025
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0684 0.0654
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0042 0.0734 0.0835
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0684 0.0682
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0277 0.5875 0.8958
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0033 0.003
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0322 0.032
Echinococcus granulosus hypothetical protein 0.0023 0.0322 0.032
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0501 0.0499
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1145 0.1142
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0322 0.0291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0033 0.0033
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Schistosoma mansoni myosin xvIII 0.0023 0.0322 0.0291
Toxoplasma gondii hypothetical protein 0.004 0.0684 0.2595
Trypanosoma brucei C-8 sterol isomerase, putative 0.0381 0.8157 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) solute carrier family 6 member 4 0.0234 0.4942 0.4941
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0322 0.032
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0012 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0684 0.0682
Schistosoma mansoni hypothetical protein 0.0398 0.8517 0.8512
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0233 0.0231
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0322 0.032
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0381 0.8157 0.8157
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0121 0.2471 0.3716
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0011 0.0058 0.0055
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0234 0.4942 0.4926
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.0322 0.032
Brugia malayi Dopamine receptor protein 2 0.0023 0.0322 0.0322
Schistosoma mansoni histamine h1 receptor 0.0023 0.0322 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0233 0.0726
Toxoplasma gondii NADPH-glutathione reductase 0.0042 0.0734 0.2803
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0033 0.003
Chlamydia trachomatis glutamine binding protein 0.002 0.0243 0.2735
Loa Loa (eye worm) hypothetical protein 0.0234 0.4942 0.4941
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0501 0.0499
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0042 0.0734 1
Echinococcus granulosus g protein coupled receptor 0.0023 0.0322 0.032
Onchocerca volvulus 0.0028 0.0424 0.0393
Brugia malayi G-protein coupled receptor 0.0023 0.0322 0.0322
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0033 0.003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0734 0.0835
Echinococcus granulosus dnaJ subfamily B 0.0398 0.8517 0.8516
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0684 0.0682
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0031 0.049 0.049
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1409 0.1668
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0322 0.032
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0991 0.0989
Loa Loa (eye worm) hypothetical protein 0.0381 0.8157 0.8157
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0684 0.0654
Schistosoma mansoni hypothetical protein 0.0023 0.0322 0.0291
Schistosoma mansoni hypothetical protein 0.0019 0.0233 0.0201
Schistosoma mansoni neuropeptide receptor 0.0023 0.0322 0.0291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0033 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0033 0.003
Loa Loa (eye worm) hypothetical protein 0.0099 0.1988 0.1986
Echinococcus granulosus g protein coupled receptor 0.0023 0.0322 0.032
Schistosoma mansoni glutamate synthase 0.0011 0.0058 0.0025
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0042 0.0734 0.5006
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0042 0.0734 0.5006
Plasmodium falciparum thioredoxin reductase 0.0121 0.2471 1
Loa Loa (eye worm) hypothetical protein 0.0234 0.4942 0.4941
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0033 0.003
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0042 0.0734 0.1042
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0065 0.1242 0.1823
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0322 0.0322
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0322 0.032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0816 0.0814
Brugia malayi GnHR receptor homolog 0.0023 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi larval opioid receptor 0.0023 0.0322 0.0322
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0033 0.003
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0322 0.032
Echinococcus multilocularis glutamate receptor 2 0.0012 0.0067 0.0064
Loa Loa (eye worm) hypothetical protein 0.0054 0.0991 0.0989
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0322 0.032
Brugia malayi Serotonin receptor 0.0023 0.0322 0.0322
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1145 0.1342
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0322 0.032
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0322 0.032
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0684 0.0654
Trypanosoma cruzi trypanothione reductase, putative 0.0042 0.0734 0.0835
Plasmodium vivax hypothetical protein, conserved 0.004 0.0684 0.2595
Echinococcus granulosus neuropeptide receptor 0.0023 0.0322 0.032
Giardia lamblia NADH oxidase lateral transfer candidate 0.0042 0.0734 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0848 0.0846
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.002 0.0243 0.0285
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0381 0.8157 1
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0322 0.032
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0058 0.0025
Plasmodium vivax amine transporter, putative 0.004 0.0684 0.2595
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0322 0.0291
Plasmodium vivax glutathione reductase, putative 0.0121 0.2471 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0322 0.032
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0322 0.0291
Echinococcus multilocularis glutamate synthase 0.0011 0.0058 0.0055
Schistosoma mansoni sodium/chloride dependent transporter 0.0234 0.4942 0.4926
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.1409 0.1407
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0011 0.0058 0.0055
Schistosoma mansoni hypothetical protein 0.0023 0.0322 0.0291
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0322 0.032
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0234 0.4942 0.4942
Schistosoma mansoni hypothetical protein 0.0023 0.0322 0.0291
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0322 0.032
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.041 0.0408
Loa Loa (eye worm) hypothetical protein 0.0019 0.0233 0.0231
Brugia malayi follicle stimulating hormone receptor 0.0254 0.5365 0.5365
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0011 0.0058 0.0055
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0322 0.0291
Loa Loa (eye worm) serotonin transporter b 0.0234 0.4942 0.4941
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0816 0.0814
Loa Loa (eye worm) thioredoxin reductase 0.0121 0.2471 0.2469
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Onchocerca volvulus 0.0023 0.0322 0.0291
Echinococcus granulosus orexin receptor type 2 0.0023 0.0322 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0322 0.032
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0684 0.9257
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0322 0.0322
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0322 0.032
Schistosoma mansoni inositol monophosphatase 0.0073 0.1409 0.1381
Schistosoma mansoni amine GPCR 0.0023 0.0322 0.0291
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.0067 0.0064
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0042 0.0734 0.2803
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.13 0.13
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Echinococcus granulosus allatostatin A receptor 0.0023 0.0322 0.032
Leishmania major C-8 sterol isomerase-like protein 0.0381 0.8157 1
Echinococcus granulosus serotonin transporter 0.0234 0.4942 0.4941
Schistosoma mansoni amine GPCR 0.0023 0.0322 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0033 0.0033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0816 0.0814
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0042 0.0734 0.0835
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Leishmania major trypanothione reductase 0.0121 0.2471 0.2979
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0042 0.0734 0.5006
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0322 0.032
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.002 0.0243 0.0379
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0042 0.0734 0.0835
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0322 0.0322
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0684 0.0682
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0065 0.1242 0.1823
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Mycobacterium tuberculosis Probable oxidoreductase 0.0308 0.6552 1
Schistosoma mansoni hypothetical protein 0.0287 0.6103 0.6091
Brugia malayi putative neuropeptide receptor 0.0023 0.0322 0.0322
Plasmodium falciparum thioredoxin reductase 0.0042 0.0734 0.2803
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0322 0.032
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Schistosoma mansoni opsin-like receptor 0.0023 0.0322 0.0291
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) hypothetical protein 0.0019 0.0233 0.0231
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0322 0.032
Onchocerca volvulus 0.0023 0.0322 0.0291
Trypanosoma brucei trypanothione reductase 0.0121 0.2471 0.2979
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1145 0.8043
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0322 0.032
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.1409 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0033 0.003
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.2323 0.2321
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0684 0.0682
Brugia malayi G protein-coupled receptor 0.0023 0.0322 0.0322
Brugia malayi Serotonin receptor 0.0023 0.0322 0.0322
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0322 0.032
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.002 0.0243 0.2735
Schistosoma mansoni inositol monophosphatase 0.0073 0.1409 0.1381
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Schistosoma mansoni sulfide quinone reductase 0.0011 0.0058 0.0025
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.041 0.0408
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1145 0.1116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0816 0.0814
Onchocerca volvulus 0.004 0.0684 0.0654
Onchocerca volvulus 0.0047 0.0848 0.0818
Echinococcus multilocularis serotonin receptor 0.0023 0.0322 0.032
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0322 0.032
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0322 0.0322
Echinococcus granulosus glutamate receptor 2 0.0012 0.0067 0.0064
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0322 0.032
Schistosoma mansoni biogenic amine receptor 0.0023 0.0322 0.0291
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0042 0.0734 0.0835
Schistosoma mansoni vesicular acetylcholine transporter 0.0465 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0322 0.0291
Brugia malayi neuropeptide F receptor 0.0023 0.0322 0.0322
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0322 0.0291
Schistosoma mansoni cpg binding protein 0.0028 0.0424 0.0393
Schistosoma mansoni cpg binding protein 0.003 0.0459 0.0428
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0042 0.0734 0.2803
Onchocerca volvulus 0.0023 0.0322 0.0291
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0501 0.0499
Loa Loa (eye worm) hypothetical protein 0.004 0.0684 0.0682
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0033 0.003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0322 0.0322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0033 0.003
Echinococcus granulosus neuropeptide s receptor 0.0023 0.0322 0.032
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0322 0.0291
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0991 0.0989
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0322 0.0291
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0011 0.0058 0.0058
Schistosoma mansoni neuropeptide receptor 0.0023 0.0322 0.0291
Schistosoma mansoni eyes absent homolog 0.0086 0.1706 0.1679
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0042 0.0734 0.2803
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0971 0.3785
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0322 0.032
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0042 0.0734 0.2803
Plasmodium falciparum amino acid transporter, putative 0.004 0.0684 0.2595
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0322 0.032
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0233 0.0231
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0322 0.0291
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0012 0.0067 0.0064
Schistosoma mansoni lipoxygenase 0.008 0.1568 0.154
Schistosoma mansoni rab6-interacting 0.0019 0.0233 0.0201
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0011 0.0058 0.0055
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0322 0.032
Brugia malayi nuclear hormone receptor 0.001 0.0033 0.0033
Onchocerca volvulus 0.0023 0.0322 0.0291
Schistosoma mansoni lipoxygenase 0.0115 0.2323 0.2298
Schistosoma mansoni cpg binding protein 0.003 0.0459 0.0428
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Melatonin receptor type 1A 0.0023 0.0322 0.0322
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0848 0.0846
Schistosoma mansoni hypothetical protein 0.0068 0.13 0.1271
Brugia malayi mbt repeat family protein 0.0047 0.0848 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0033 0.0033
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0684 0.0654
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0033 0.003
Brugia malayi hypothetical protein 0.0023 0.0322 0.0322
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1988 0.1986
Schistosoma mansoni amine GPCR 0.0023 0.0322 0.0291
Treponema pallidum NADH oxidase 0.0042 0.0734 0.1385
Echinococcus multilocularis serotonin transporter 0.0234 0.4942 0.4941
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1145 0.1116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0033 0.0033
Loa Loa (eye worm) MBCTL1 0.0054 0.0991 0.0989
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.1409 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0033 0.003
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0322 0.032
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0848 0.0818
Loa Loa (eye worm) hypothetical protein 0.0023 0.0322 0.032
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.041 0.0408
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0122 0.2493 0.2491
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0322 0.0291
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.111 0.1081

Activities

Activity type Activity value Assay description Source Reference
K ass (binding) = 9.8 l M-1 Binding affinity for human Prothrombin as apparent association constant (Kass) ChEMBL. 10091685
K ass (binding) = 9.8 l M-1 Binding affinity for human Prothrombin as apparent association constant (Kass) ChEMBL. 10091685
K ass (binding) = 13.23 l M-1 Binding affinity for human Prothrombin as apparent association constant (Kass) ChEMBL. 10091685
K ass (binding) = 13.23 l M-1 Binding affinity for human Prothrombin as apparent association constant (Kass) ChEMBL. 10091685

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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