Detailed information for compound 2097989

Basic information

Technical information
  • TDR Targets ID: 2097989
  • Name: ethyl (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17 R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclo penta[a]phenanthren-17-yl]pentanoate
  • MW: 420.625 | Formula: C26H44O4
  • H donors: 2 H acceptors: 3 LogP: 5.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)[C@@H](O)C[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@H](C2)O)C
  • InChi: 1S/C26H44O4/c1-5-30-24(29)11-6-16(2)20-9-10-21-19-8-7-17-14-18(27)12-13-25(17,3)22(19)15-23(28)26(20,21)4/h16-23,27-28H,5-15H2,1-4H3/t16-,17-,18-,19+,20-,21+,22+,23+,25+,26-/m1/s1
  • InChiKey: ZFVNCIMEWULGEX-VAYUFCLWSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid ethyl ester
  • (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid ethyl ester
  • ZINC05223027
  • ST024725

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0031 0.0111 1
Toxoplasma gondii AGC kinase 0.0025 0.004 0.0442
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0081 0.7348
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0025 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0047 0.0302 0.0302
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0302 0.032
Loa Loa (eye worm) cysteine protease 0.0031 0.0111 0.0112
Brugia malayi Protein kinase c protein 2 0.0048 0.0308 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0294 0.0294
Echinococcus granulosus protein kinase c iota type 0.0313 0.3425 0.3425
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2714 1
Schistosoma mansoni unc-13 (munc13) 0.0047 0.0302 0.0302
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0193 0.2009 0.2009
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0081 0.0081
Echinococcus granulosus cathepsin L 0.0031 0.0111 0.0111
Trypanosoma cruzi cysteine protease, putative 0.0031 0.0111 0.0363
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0098 0.09 0.2953
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3046 0.3046
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3046 0.3046
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0081 0.0081
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0022 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.004 0.004
Brugia malayi jmjC domain containing protein 0.0035 0.0152 0.0161
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0111 0.2706
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0285 0.3095 1
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0048 0.0308 0.0308
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Brugia malayi Bromodomain containing protein 0.0029 0.0081 0.0086
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0152 0.0152
Echinococcus multilocularis Rac GTPase activating protein 1 0.0047 0.0302 0.0302
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0047 0.0302 0.0302
Echinococcus multilocularis serine:threonine protein kinase 38 0.0025 0.004 0.004
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0072 0.0595 0.0602
Toxoplasma gondii cathepsin B 0.0098 0.09 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0308 0.0308
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Echinococcus multilocularis cysteine protease 0.0031 0.0111 0.0111
Brugia malayi jmjC domain containing protein 0.0093 0.0844 0.0893
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0031 0.0111 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2714 1
Brugia malayi diacylglycerol kinase 0.0047 0.0302 0.032
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.1906 0.1906
Brugia malayi Ras association domain family 1 isoform A 0.0047 0.0302 0.032
Echinococcus multilocularis protein kinase c eta type 0.0047 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0281 0.3046 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0081 0.7348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Entamoeba histolytica hypothetical protein 0.0047 0.0302 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Giardia lamblia Cathepsin B precursor 0.0098 0.09 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Brugia malayi Cathepsin L-like precursor 0.0031 0.0111 0.0117
Schistosoma mansoni rac gtpase activating protein 0.0047 0.0302 0.0302
Echinococcus multilocularis N chimaerin 0.0047 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0307 0.3349 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0111 0.0111
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.032 0.3503 0.3503
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0308 0.0308
Loa Loa (eye worm) ctsf protein 0.0031 0.0111 0.0112
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0081 0.0082
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0281 0.3046 0.3046
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0618 0.0618
Brugia malayi protein kinase C3,putative 0.0289 0.3138 0.3323
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2714 1
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0111 0.2706
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0048 0.0308 0.0308
Brugia malayi RhoGEF domain containing protein 0.0047 0.0302 0.032
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0438 0.0443
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0025 0.004 0.004
Schistosoma mansoni tyrosine kinase 0.031 0.3393 0.3393
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0111 0.2706
Loa Loa (eye worm) raf kinase 0.0864 0.9891 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0294 0.1739
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0111 0.0363
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0111 0.2706
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.9065 0.9065
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0025 0.004 0.004
Onchocerca volvulus Alhambra homolog 0.0029 0.0081 0.048
Plasmodium vivax unspecified product 0.0031 0.0111 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0307 0.3349 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.004 0.004
Brugia malayi Cathepsin L-like precursor 0.0031 0.0111 0.0117
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0487 0.5469 0.5529
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0098 0.09 0.09
Plasmodium falciparum cysteine proteinase falcipain 3 0.0031 0.0111 1
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0306 0.3346 0.3383
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0047 0.0302 0.0305
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Echinococcus granulosus protein tyrosine kinase 0.0255 0.2745 0.2745
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.037 0.0392
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2714 1
Loa Loa (eye worm) cathepsin B 0.0098 0.09 0.091
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Echinococcus multilocularis serine:threonine protein kinase N2 0.0025 0.004 0.004
Brugia malayi Cathepsin L-like precursor 0.0031 0.0111 0.0117
Echinococcus multilocularis geminin 0.0166 0.1694 0.1694
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0025 0.004 0.004
Brugia malayi p70 ribosomal S6 kinase beta 0.0025 0.004 0.0042
Onchocerca volvulus 0.0047 0.0302 0.1783
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Loa Loa (eye worm) AGC/AKT protein kinase 0.0025 0.004 0.004
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0302 0.0302
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0213 0.0213
Brugia malayi RhoGAP domain containing protein 0.0047 0.0302 0.032
Echinococcus multilocularis cathepsin L 0.0031 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Schistosoma mansoni vav2 0.0047 0.0302 0.0302
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0294 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0302 1
Schistosoma mansoni protein kinase C mu 0.0048 0.0308 0.0308
Echinococcus granulosus Rac GTPase activating protein 1 0.0047 0.0302 0.0302
Echinococcus multilocularis epidermal growth factor receptor 0.032 0.3503 0.3503
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0081 0.0904
Brugia malayi Protein kinase domain containing protein 0.0048 0.0308 0.0326
Brugia malayi Immunoglobulin I-set domain containing protein 0.0156 0.1582 0.1675
Plasmodium vivax vivapain-3 0.0031 0.0111 1
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0047 0.0302 0.0305
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0111 0.0363
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2714 1
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Echinococcus granulosus jumonji domain containing protein 0.004 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0053 0.037 0.0374
Schistosoma mansoni hypothetical protein 0.0166 0.1694 0.1694
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0152 0.0152
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0111 0.2706
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Loa Loa (eye worm) MBCTL1 0.0053 0.037 0.0374
Echinococcus granulosus cathepsin L cysteine protease 0.0031 0.0111 0.0111
Schistosoma mansoni tyrosine kinase 0.0255 0.2745 0.2745
Echinococcus granulosus protein kinase c eta type 0.0047 0.0302 0.0302
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0152 0.0154
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0111 0.0654
Brugia malayi Protein kinase domain containing protein 0.0025 0.004 0.0042
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0111 0.0111
Toxoplasma gondii diacylglycerol kinase, putative 0.0047 0.0302 0.3357
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0031 0.0111 0.0111
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0025 0.004 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Onchocerca volvulus 0.0031 0.0111 0.0654
Echinococcus granulosus cathepsin b 0.0281 0.3046 0.3046
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0047 0.0302 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0081 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0595 0.0595
Brugia malayi Raf kinase 0.0826 0.9444 1
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0025 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0029 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Echinococcus granulosus serine:threonine protein kinase N2 0.0025 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0111 0.0288
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0844 0.0844
Echinococcus granulosus unc 13 munc13 0.0047 0.0302 0.0302
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0294 0.0294
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0111 0.0117
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0111 0.0117
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0031 0.0111 0.0111
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0152 0.0152
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0025 0.004 0.004
Loa Loa (eye worm) AGC/PKN protein kinase 0.0025 0.004 0.004
Brugia malayi Protein kinase domain containing protein 0.0258 0.2779 0.2943
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0112
Schistosoma mansoni protein kinase C 0.0047 0.0302 0.0302
Echinococcus granulosus Diacylglycerol kinase theta 0.0047 0.0302 0.0302
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0294 0.0294
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0193 0.2009 0.2009
Schistosoma mansoni tyrosine kinase 0.032 0.3503 0.3503
Echinococcus granulosus cathepsin b 0.0281 0.3046 0.3046
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.037 0.037
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1694 1
Onchocerca volvulus 0.0031 0.0111 0.0654
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0072 0.0595 0.0595
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0025 0.004 0.004
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0156 0.1582 0.1599
Onchocerca volvulus 0.0031 0.0111 0.0654
Brugia malayi C1-like domain containing protein 0.0048 0.0308 0.0326
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0048 0.0308 0.0312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Brugia malayi Protein kinase domain containing protein 0.0025 0.004 0.0042
Toxoplasma gondii cathepsin CPL 0.0031 0.0111 0.123
Echinococcus granulosus NDR protein kinase 0.0025 0.004 0.004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0031 0.0111 0.0112
Echinococcus multilocularis peregrin 0.0029 0.0081 0.0081
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.3046 0.3046
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0294 0.0294
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Brugia malayi PHD-finger family protein 0.0029 0.0081 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Onchocerca volvulus 0.0031 0.0111 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Loa Loa (eye worm) TK/FAK protein kinase 0.0258 0.2779 0.281
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0111 0.0363
Echinococcus multilocularis cathepsin b 0.0281 0.3046 0.3046
Echinococcus granulosus myotubularin protein 13 0.0047 0.0302 0.0302
Schistosoma mansoni tyrosine kinase 0.0193 0.2009 0.2009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0152 0.0152
Trypanosoma brucei cysteine peptidase C (CPC) 0.0098 0.09 1
Brugia malayi Papain family cysteine protease containing protein 0.0031 0.0111 0.0117
Leishmania major cathepsin L-like protease 0.0031 0.0111 0.123
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1798 0.6584
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0595 0.0595
Echinococcus granulosus protein kinase c epsilon type 0.0072 0.0595 0.0595
Echinococcus multilocularis protein tyrosine kinase 0.0255 0.2745 0.2745
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Loa Loa (eye worm) RasGEF domain-containing protein 0.0047 0.0302 0.0305
Echinococcus granulosus N chimaerin 0.0047 0.0302 0.0302
Echinococcus multilocularis protein kinase c iota type 0.0313 0.3425 0.3425
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Schistosoma mansoni hypothetical protein 0.0284 0.3079 0.3079
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Brugia malayi Cathepsin L-like precursor 0.0031 0.0111 0.0117
Echinococcus granulosus cathepsin L cysteine proteinase 0.0031 0.0111 0.0111
Onchocerca volvulus 0.0135 0.1331 0.7856
Loa Loa (eye worm) TK/INSR protein kinase 0.0193 0.2009 0.2031
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Plasmodium vivax vivapain-1 0.0031 0.0111 1
Plasmodium vivax vivapain-2 0.0031 0.0111 1
Giardia lamblia Cathepsin B precursor 0.0098 0.09 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0873 1 1
Schistosoma mansoni hypothetical protein 0.0166 0.1694 0.1694
Schistosoma mansoni serine/threonine protein kinase 0.0873 1 1
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Echinococcus granulosus cathepsin l cysteine peptidase 0.0031 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Echinococcus multilocularis cathepsin L cysteine protease 0.0031 0.0111 0.0111
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.0302 0.0302
Brugia malayi mbt repeat family protein 0.0047 0.0294 0.0312
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Onchocerca volvulus 0.0031 0.0111 0.0654
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Echinococcus multilocularis serine threonine protein kinase 0.0025 0.004 0.004
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0047 0.0302 0.0302
Entamoeba histolytica diacylglycerol kinase, putative 0.0047 0.0302 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Onchocerca volvulus 0.0047 0.0302 0.1783
Plasmodium falciparum cysteine proteinase falcipain 1 0.0031 0.0111 1
Schistosoma mansoni tyrosine kinase 0.032 0.3503 0.3503
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.1906 0.1906
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0111 0.0363
Loa Loa (eye worm) hypothetical protein 0.0049 0.0321 0.0324
Entamoeba histolytica cysteine proteinase, putative 0.0031 0.0111 0.2706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Loa Loa (eye worm) hypothetical protein 0.0047 0.0294 0.0298
Giardia lamblia Cathepsin B precursor 0.0098 0.09 1
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0111 0.0363
Echinococcus granulosus peregrin 0.0029 0.0081 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0294 0.0294
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0844 0.0844
Echinococcus multilocularis insulin receptor 0.0193 0.2009 0.2009
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.2714 0.2744
Echinococcus multilocularis cysteine protease 0.0031 0.0111 0.0111
Brugia malayi protein kinase C II. 0.0072 0.0595 0.063
Loa Loa (eye worm) hypothetical protein 0.0281 0.3046 0.308
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Brugia malayi cathepsin B-like cysteine proteinase 0.0281 0.3046 0.3225
Echinococcus granulosus epidermal growth factor receptor 0.059 0.6677 0.6677
Leishmania major cysteine peptidase A (CPA) 0.0031 0.0111 0.123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0302 0.0305
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0098 0.09 1
Schistosoma mansoni atypical protein kinase C 0.0331 0.3633 0.3633
Schistosoma mansoni tyrosine kinase 0.031 0.3393 0.3393
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0098 0.09 0.3231
Trypanosoma cruzi cruzipain precursor, putative 0.0031 0.0111 0.0363
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Brugia malayi Pleckstrin Homology Domain 0.0047 0.0302 0.032
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0031 0.0111 0.0363
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.2714 0.2874
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.037 0.037
Brugia malayi Protein kinase domain containing protein 0.0025 0.004 0.0042
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0111 0.0111
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0047 0.0302 0.0302
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0025 0.004 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0031 0.0111 0.0363
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Entamoeba histolytica cysteine proteinase 2 0.0031 0.0111 0.2706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Echinococcus granulosus geminin 0.0166 0.1694 0.1694
Brugia malayi Cathepsin L-like precursor 0.0031 0.0111 0.0117
Brugia malayi mbt repeat family protein 0.0047 0.0294 0.0312
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.037 0.037
Loa Loa (eye worm) AGC/NDR protein kinase 0.0025 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Onchocerca volvulus Tyrosine kinase homolog 0.0147 0.1467 0.8664
Brugia malayi Hr1 repeat family protein 0.0025 0.004 0.0042
Onchocerca volvulus Cathepsin F homolog 0.0031 0.0111 0.0654
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Echinococcus multilocularis Diacylglycerol kinase theta 0.0047 0.0302 0.0302
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0025 0.004 0.004
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2714 1
Trypanosoma cruzi cysteine proteinase, putative 0.0031 0.0111 0.0363
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.004 0.004
Onchocerca volvulus 0.0047 0.0294 0.1739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1798 0.6584
Entamoeba histolytica cysteine proteinase 1, putative 0.0031 0.0111 0.2706
Echinococcus granulosus epidermal growth factor receptor 0.032 0.3503 0.3503
Brugia malayi Cathepsin L-like precursor 0.0031 0.0111 0.0117
Loa Loa (eye worm) fibroinase 0.0031 0.0111 0.0112
Schistosoma mansoni protein kinase C mu 0.0047 0.0302 0.0302
Echinococcus granulosus cysteine protease 0.0031 0.0111 0.0111
Brugia malayi Protein kinase domain containing protein 0.0193 0.2009 0.2127
Brugia malayi Furin-like cysteine rich region family protein 0.059 0.6677 0.707
Echinococcus granulosus protein kinase C gamma type 0.0025 0.004 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0031 0.0111 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1694 0.6193
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0595 0.0595
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.0302 0.0305
Echinococcus multilocularis cathepsin b 0.0281 0.3046 0.3046
Plasmodium vivax vivapain-2 0.0031 0.0111 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0072 0.0595 0.0595
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0081 0.0904
Schistosoma mansoni tyrosine kinase 0.0193 0.2009 0.2009
Echinococcus multilocularis unc 13 (munc13) 0.0047 0.0302 0.0302
Echinococcus multilocularis myotubularin protein 13 0.0047 0.0302 0.0302
Brugia malayi diacylglycerol kinase 0.0047 0.0302 0.032
Schistosoma mansoni tyrosine kinase 0.059 0.6677 0.6677
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0031 0.0111 0.0112
Onchocerca volvulus 0.0031 0.0111 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0048 0.0308 0.0326
Schistosoma mansoni cathepsin F (C01 family) 0.0031 0.0111 0.0111
Onchocerca volvulus Cathepsin L homolog 0.0031 0.0111 0.0654
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0294 0.0294
Echinococcus multilocularis 0.0181 0.187 0.187
Trichomonas vaginalis AGC family protein kinase 0.0025 0.004 0.0024
Schistosoma mansoni tyrosine kinase 0.031 0.3393 0.3393
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0081 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0031 0.0111 0.0825
Echinococcus granulosus insulin receptor 0.0193 0.2009 0.2009
Brugia malayi RhoGAP domain containing protein 0.0047 0.0302 0.032
Loa Loa (eye worm) TK/EGFR protein kinase 0.059 0.6677 0.6751
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0031 0.0111 0.0288
Schistosoma mansoni serine/threonine kinase 0.0025 0.004 0.004
Schistosoma mansoni diacylglycerol kinase theta 0.0047 0.0302 0.0302
Schistosoma mansoni unc-13 (munc13) 0.0047 0.0302 0.0302
Onchocerca volvulus 0.0031 0.0111 0.0654
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0031 0.0111 0.0288
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Onchocerca volvulus 0.0047 0.0302 0.1783
Echinococcus multilocularis epidermal growth factor receptor 0.059 0.6677 0.6677
Echinococcus multilocularis protein kinase c epsilon type 0.0072 0.0595 0.0595
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0294 0.0294
Echinococcus granulosus cathepsin l1 0.0031 0.0111 0.0111
Entamoeba histolytica cysteine protease, putative 0.0031 0.0111 0.2706

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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