Detailed information for compound 209840

Basic information

Technical information
  • TDR Targets ID: 209840
  • Name: 5-N-methyl-5-N-[(2-methylphenyl)methyl]-6-[2- (6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimid ine-4,5-diamine
  • MW: 414.503 | Formula: C24H26N6O
  • H donors: 1 H acceptors: 3 LogP: 2.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncnc(c1N(Cc1ccccc1C)C)C#Cc1ccc(nc1)N1CCOCC1
  • InChi: 1S/C24H26N6O/c1-18-5-3-4-6-20(18)16-29(2)23-21(27-17-28-24(23)25)9-7-19-8-10-22(26-15-19)30-11-13-31-14-12-30/h3-6,8,10,15,17H,11-14,16H2,1-2H3,(H2,25,27,28)
  • InChiKey: WNXUNRFTZZKNRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N5-methyl-6-[2-(6-morpholino-3-pyridyl)ethynyl]-N5-(o-tolylmethyl)pyrimidine-4,5-diamine
  • N5-methyl-N5-[(2-methylphenyl)methyl]-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidine-4,5-diamine
  • [4-amino-6-[2-(6-morpholino-3-pyridyl)ethynyl]pyrimidin-5-yl]-methyl-(2-methylbenzyl)amine
  • N'-methyl-N'-[(2-methylphenyl)methyl]-6-[2-(6-morpholin-4-ylpyridin-3-yl)ethynyl]pyrimidine-4,5-diamine
  • N'-methyl-N'-[(2-methylphenyl)methyl]-6-[2-(6-morpholino-3-pyridyl)ethynyl]pyrimidine-4,5-diamine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania braziliensis adenosine kinase-like protein Adenosine kinase   361 aa 351 aa 37.6 %
Schistosoma mansoni ribokinase Adenosine kinase   361 aa 289 aa 23.2 %
Leishmania mexicana adenosine kinase-like protein Adenosine kinase   361 aa 344 aa 36.6 %
Candida albicans similar to Ribokinase Adenosine kinase   361 aa 309 aa 20.7 %
Leishmania major adenosine kinase-like protein Adenosine kinase   361 aa 351 aa 36.8 %
Leishmania infantum adenosine kinase-like protein Adenosine kinase   361 aa 351 aa 37.6 %
Leishmania donovani adenosine kinase-like protein Adenosine kinase   361 aa 351 aa 37.6 %
Candida albicans similar to Ribokinase Adenosine kinase   361 aa 303 aa 21.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Brugia malayi neuropeptide F receptor 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.004 0.0094 0.0114
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0085 0.6794
Onchocerca volvulus 0.0058 0.0157 0.019
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0234 0.0752 0.0911
Onchocerca volvulus 0.004 0.0094 0.0114
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0085 0.1125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Echinococcus multilocularis serotonin transporter 0.0234 0.0752 0.0911
Onchocerca volvulus 0.0058 0.0157 0.019
Brugia malayi Pre-SET motif family protein 0.0206 0.0658 0.0658
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0157 0.019
Schistosoma mansoni glutamate receptor NMDA 0.0015 0.001 0.0012
Onchocerca volvulus 0.0058 0.0157 0.019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0085 0.0085
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0015 0.001 0.0012
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0023 0.0232
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Echinococcus granulosus allatostatin A receptor 0.0058 0.0157 0.019
Echinococcus multilocularis neuropeptide receptor 0.0058 0.0157 0.019
Schistosoma mansoni histamine h1 receptor 0.0058 0.0157 0.019
Onchocerca volvulus 0.0058 0.0157 0.019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0157 0.019
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0036 0.0043
Onchocerca volvulus 0.0058 0.0157 0.019
Schistosoma mansoni ATP-binding cassette transporter 0.0015 0.001 0.0012
Brugia malayi Dopamine receptor protein 2 0.0058 0.0157 0.0157
Loa Loa (eye worm) glutamate receptor 1 0.0015 0.001 0.001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0321 0.3227
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.0157 0.019
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.006 0.0072
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0028
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0038 0.0089 0.0893
Schistosoma mansoni amine GPCR 0.0058 0.0157 0.019
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0316 0.0316
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0094 0.0114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni glutamate receptor kainate 0.0015 0.001 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Mycobacterium ulcerans phytoene synthase, CrtB 0.0154 0.0483 0.485
Loa Loa (eye worm) norepinephrine transporter 0.0234 0.0752 0.0752
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.004 0.0094 0.0094
Schistosoma mansoni neuropeptide receptor 0.0058 0.0157 0.019
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.0157 0.019
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.004 0.0094 0.0114
Echinococcus multilocularis neuropeptide receptor 0.0058 0.0157 0.019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 0.0157 0.019
Schistosoma mansoni survival motor neuron protein 0.0047 0.0119 0.0144
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.0094
Brugia malayi vesicular acetylcholine transporter unc-17 0.2449 0.826 0.826
Echinococcus multilocularis somatostatin receptor 0.0058 0.0157 0.019
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.006 0.006
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0176 0.0555 0.0555
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0139 0.0169
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 0.0157 0.019
Entamoeba histolytica hypothetical protein, conserved 0.0306 0.0995 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.0157 0.019
Trypanosoma brucei squalene synthase, putative 0.0495 0.1639 0.1639
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.0157 0.019
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0157 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0023 0.0306
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0014 0.0144
Brugia malayi hypothetical protein 0.023 0.074 0.074
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0014 0.0144
Schistosoma mansoni biogenic amine receptor 0.0058 0.0157 0.019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0458 0.1512 0.1512
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.006 0.0072
Schistosoma mansoni opsin-like receptor 0.0058 0.0157 0.019
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0321 0.8883
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 0.0157 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0058 0.0157 0.019
Echinococcus multilocularis neuropeptide s receptor 0.0058 0.0157 0.019
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 0.0157 0.019
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 0.0157 0.019
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.0157 0.019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0036 0.0043
Onchocerca volvulus 0.0058 0.0157 0.019
Plasmodium vivax SET domain protein, putative 0.003 0.006 0.4731
Echinococcus multilocularis Squalene phytoene synthase 0.0154 0.0483 0.0585
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0157 0.019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.2978
Brugia malayi larval opioid receptor 0.0058 0.0157 0.0157
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 0.0157 0.019
Schistosoma mansoni neuropeptide receptor 0.0058 0.0157 0.019
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0089 0.9353
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0015 0.001 0.0012
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.0316 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Schistosoma mansoni adenosine kinase 0.0105 0.0316 0.0382
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0014 0.0014
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.0157 0.019
Toxoplasma gondii thioredoxin reductase 0.0047 0.0118 0.374
Schistosoma mansoni hypothetical protein 0.0047 0.0119 0.0144
Brugia malayi Dopamine receptor 0.0058 0.0157 0.0157
Brugia malayi ORL1-like opioid receptor 0.0058 0.0157 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0058 0.0157 0.019
Schistosoma mansoni sphingosine kinase A B 0.0306 0.0995 0.1205
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0085 0.0103
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus geminin 0.0333 0.1087 0.1316
Onchocerca volvulus 0.0234 0.0754 0.0913
Echinococcus multilocularis nmda type glutamate receptor 0.0053 0.0139 0.0169
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0754 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Brugia malayi Serotonin receptor 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0157 0.019
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0085 0.0085
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2962 1 1
Echinococcus granulosus Squalene phytoene synthase 0.0154 0.0483 0.0585
Echinococcus granulosus g-protein coupled receptor 0.0058 0.0157 0.019
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.0157 0.019
Trypanosoma cruzi phytoene synthase, putative 0.0154 0.0483 0.0483
Mycobacterium tuberculosis Conserved protein 0.0306 0.0995 1
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.0157 0.019
Schistosoma mansoni DNA polymerase eta 0.0019 0.0023 0.0028
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0015 0.001 0.0012
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.0157 0.019
Echinococcus multilocularis geminin 0.0333 0.1087 0.1316
Chlamydia trachomatis glutamine binding protein 0.0038 0.0089 0.9353
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0015 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0234 0.0752 0.0752
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0023 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 0.0157 0.019
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.004 0.0094 0.0114
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.0157 0.0157
Echinococcus multilocularis vesicular acetylcholine transporter 0.2449 0.826 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0023 0.0232
Echinococcus granulosus neuropeptide receptor 0.0058 0.0157 0.019
Schistosoma mansoni adenoreceptor 0.0058 0.0157 0.019
Onchocerca volvulus 0.0234 0.0752 0.0911
Onchocerca volvulus 0.0047 0.0119 0.0144
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.0232
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus biogenic amine 5HT receptor 0.0176 0.0555 0.0672
Schistosoma mansoni amine GPCR 0.0058 0.0157 0.019
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0176 0.0555 0.0555
Brugia malayi G protein-coupled receptor 0.0058 0.0157 0.0157
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0015 0.001 0.0012
Echinococcus granulosus glutamate NMDA receptor subunit 0.0015 0.001 0.0012
Echinococcus multilocularis orexin receptor type 2 0.0058 0.0157 0.019
Schistosoma mansoni hypothetical protein 0.0058 0.0157 0.019
Plasmodium falciparum transporter, putative 0.004 0.0094 0.768
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.0094
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 0.0157 0.019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.006 0.0072
Schistosoma mansoni glutamate receptor NMDA 0.0023 0.0036 0.0043
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0021 0.0666
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.0157 0.0157
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.0157 0.0157
Schistosoma mansoni adenosine kinase 0.0105 0.0316 0.0382
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.0157 0.0157
Brugia malayi sulfakinin receptor protein 0.0058 0.0157 0.0157
Plasmodium falciparum thioredoxin reductase 0.0047 0.0118 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0085 0.0085
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0321 0.3227
Schistosoma mansoni hypothetical protein 0.0058 0.0157 0.019
Trypanosoma cruzi squalene synthase, putative 0.0495 0.1639 0.1639
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0085 0.0103
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0118 0.0143
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0014 0.0144
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0144
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0157 0.019
Echinococcus granulosus g protein coupled receptor 0.0058 0.0157 0.019
Echinococcus granulosus bloom syndrome protein 0.0021 0.003 0.0036
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0017
Schistosoma mansoni neuropeptide receptor 0.0058 0.0157 0.019
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0282 0.0916 0.0916
Schistosoma mansoni glutamate receptor kainate 0.0015 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0094 0.0114
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus dna polymerase eta 0.0019 0.0023 0.0028
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus G protein coupled receptor 139 0.0058 0.0157 0.019
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0014 0.0191
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0094 0.0114
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0085 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0014 0.1696
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0094 0.0114
Trypanosoma brucei unspecified product 0.0013 0.0003 0.0003
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Brugia malayi neuropeptide F receptor 0.0058 0.0157 0.0157
Echinococcus granulosus glutamate receptor 2 0.0023 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus serotonin receptor 0.0058 0.0157 0.019
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0014 0.0014
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 0.0157 0.019
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 0.0157 0.019
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0094 0.0114
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0157 0.0157
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0023 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0362 0.3633
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0089 0.1009
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0085 0.0085
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0094 0.0114
Onchocerca volvulus 0.0058 0.0157 0.019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.0157 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0014 0.0191
Trypanosoma brucei trypanothione reductase 0.0047 0.0118 0.0118
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.0157 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0003
Echinococcus granulosus uncharacterized sodium dependent transporter 0.004 0.0094 0.0114
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Onchocerca volvulus 0.0058 0.0157 0.019
Echinococcus granulosus survival motor neuron protein 1 0.023 0.074 0.0896
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.0157 0.019
Schistosoma mansoni opsin-like receptor 0.0058 0.0157 0.019
Brugia malayi GnHR receptor homolog 0.0058 0.0157 0.0157
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0094 0.0114
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0157 0.019
Trypanosoma cruzi squalene synthase, putative 0.0495 0.1639 0.1639
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0154 0.0483 0.0483
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Onchocerca volvulus 0.0058 0.0157 0.019
Onchocerca volvulus 0.0058 0.0157 0.019
Echinococcus granulosus tachykinin peptides receptor 99D 0.0058 0.0157 0.019
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.001 0.0012
Loa Loa (eye worm) RecQ helicase 0.0021 0.003 0.003
Schistosoma mansoni glutamate receptor kainate 0.0015 0.001 0.0012
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 0.0157 0.019
Mycobacterium tuberculosis Probable reductase 0.0107 0.0321 0.3227
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.0157 0.019
Schistosoma mansoni hypothetical protein 0.0333 0.1087 0.1316
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0014 0.0662
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 0.0157 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.0232
Toxoplasma gondii hypothetical protein 0.004 0.0094 0.2978
Echinococcus multilocularis sodium and chloride dependent glycine 0.004 0.0094 0.0114
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0085 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.006 0.0072
Loa Loa (eye worm) solute carrier family 6 member 4 0.0234 0.0752 0.0752
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni amine GPCR 0.0058 0.0157 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Echinococcus granulosus serotonin transporter 0.0234 0.0752 0.0911
Schistosoma mansoni biogenic amine receptor 0.0058 0.0157 0.019
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0036 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0006 0.0205
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0015 0.001 0.0012
Schistosoma mansoni myosin xvIII 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni ap endonuclease 0.0037 0.0085 0.0103
Trypanosoma brucei C-8 sterol isomerase, putative 0.2962 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.0157 0.019
Echinococcus multilocularis adenosine kinase 0.0105 0.0316 0.0382
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 0.0157 0.019
Leishmania major adenosine kinase, putative 0.0105 0.0316 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Echinococcus granulosus fmrfamide receptor 0.0058 0.0157 0.019
Brugia malayi Dopamine receptor protein 1 0.0458 0.1512 0.1512
Leishmania major squalene synthase, putative 0.0495 0.1639 0.1639
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.2978
Brugia malayi Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.0094
Echinococcus multilocularis serotonin receptor 0.0176 0.0555 0.0672
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) glutathione reductase 0.0047 0.0118 0.0118
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0118 0.0118
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Echinococcus granulosus sex peptide receptor 0.0058 0.0157 0.019
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.0157 0.0157
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0157 0.019
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0023 0.0232
Brugia malayi Adenosine kinase-like 0.0105 0.0316 0.0316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0157 0.019
Echinococcus multilocularis serotonin receptor 0.0176 0.0555 0.0672
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.006 0.0072
Onchocerca volvulus 0.004 0.0094 0.0114
Brugia malayi Melatonin receptor type 1A 0.0058 0.0157 0.0157
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0015 0.0018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0157 0.019
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.0157 0.019
Brugia malayi G-protein coupled receptor 0.0058 0.0157 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.023 0.074 0.074
Schistosoma mansoni hypothetical protein 0.0058 0.0157 0.019
Echinococcus granulosus sphingosine kinase 1 0.0306 0.0995 0.1205
Onchocerca volvulus 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0234 0.0752 0.0752
Onchocerca volvulus 0.0058 0.0157 0.019
Brugia malayi AKH receptor 0.0058 0.0157 0.0157
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.0157 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.004 0.0094 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0157 0.019
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0014 0.0456
Loa Loa (eye worm) hypothetical protein 0.0306 0.0995 0.0995
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0015 0.001 0.0012
Echinococcus multilocularis bloom syndrome protein 0.0021 0.003 0.0036
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0316 0.0316
Giardia lamblia DINP protein human, muc B family 0.0019 0.0023 0.2725
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Onchocerca volvulus 0.0058 0.0157 0.019
Schistosoma mansoni sodium/chloride dependent transporter 0.0234 0.0752 0.0911
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0094 0.0114
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.111 0.3721 0.4505
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0023 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0157 0.019
Plasmodium falciparum amino acid transporter, putative 0.004 0.0094 0.768
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 0.0157 0.019
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0036 0.0043
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0321 0.3227
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0023 0.0306
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0014 0.0662
Echinococcus granulosus sodium and chloride dependent glycine 0.004 0.0094 0.0114
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0157 0.0157
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.0157 0.019
Mycobacterium tuberculosis Probable phytoene synthase PhyA 0.0154 0.0483 0.485
Schistosoma mansoni amine GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Brugia malayi Pre-SET motif family protein 0.003 0.006 0.006
Brugia malayi RE15519p 0.0058 0.0157 0.0157
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.0157 0.0157
Trypanosoma brucei adenosine kinase, putative 0.0105 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus dro:myosuppressin receptor 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Leishmania major hypothetical protein, conserved 0.0154 0.0483 0.0483
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0118 1
Echinococcus granulosus g protein coupled receptor 0.0058 0.0157 0.019
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.004 0.0094 0.0114
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0014 0.0014
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0085 0.0852
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0362 0.3633
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0014
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0014 0.0014
Brugia malayi Glutamate receptor 1 precursor 0.0015 0.001 0.001
Schistosoma mansoni amine GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0105 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 0.0157 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Treponema pallidum sodium- and chloride- dependent transporter 0.0234 0.0752 1
Schistosoma mansoni opsin-like receptor 0.0058 0.0157 0.019
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.0157 0.019
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.006 0.1887
Onchocerca volvulus NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog 0.0154 0.0483 0.0585
Onchocerca volvulus 0.0058 0.0157 0.019
Schistosoma mansoni sodium-dependent amino acid transporter 0.004 0.0094 0.0114
Echinococcus granulosus hypothetical protein 0.0058 0.0157 0.019
Schistosoma mansoni sphingoid long chain base kinase 0.0306 0.0995 0.1205
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.0157 0.0157
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0118 0.0143
Echinococcus granulosus neuropeptide receptor 0.0058 0.0157 0.019
Leishmania major trypanothione reductase 0.0047 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0014 0.0014
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.0157 0.0157
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.0157 0.019
Brugia malayi glutathione reductase 0.0047 0.0118 0.0118
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.003 0.0396
Leishmania major DNA polymerase eta, putative 0.0019 0.0023 0.0023
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.0157 0.019
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0023 0.0036 0.0043
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0023 0.0036 0.0043
Leishmania major C-8 sterol isomerase-like protein 0.2962 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0085 0.7006
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0028
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0362 1
Brugia malayi Glutamate receptor 2 precursor 0.0015 0.001 0.001
Brugia malayi Serotonin receptor 0.0058 0.0157 0.0157
Onchocerca volvulus 0.0093 0.0275 0.0333
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0085 1
Onchocerca volvulus 0.0058 0.0157 0.019
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.2978
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0085 0.0085
Loa Loa (eye worm) glutamate receptor 2 0.0015 0.001 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.0157 0.019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0157 0.019
Echinococcus multilocularis fmrfamide receptor 0.0058 0.0157 0.019
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0157 0.0157
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 0.0157 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0038 0.0089 0.0893
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.006 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0094 0.0114
Schistosoma mansoni hypothetical protein 0.0333 0.1087 0.1316
Echinococcus multilocularis g-protein coupled receptor 0.0058 0.0157 0.019
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0023 0.0036 0.0043
Echinococcus granulosus g protein coupled receptor 0.0058 0.0157 0.019
Plasmodium falciparum glutathione reductase 0.0047 0.0118 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.1514 0.5091 0.5091
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.074 0.0896
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0118 0.0118
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0234 0.0752 0.0752
Echinococcus multilocularis NMDA receptor 0.0015 0.001 0.0012
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.004 0.0094 0.0114
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.004 0.0094 0.0114
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0016
Onchocerca volvulus 0.0058 0.0157 0.019
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2449 0.826 0.826
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.004 0.0094 0.0114
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0119 0.0119
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.0157 0.0157
Echinococcus granulosus nmda type glutamate receptor 0.0053 0.0139 0.0169
Mycobacterium ulcerans hypothetical protein 0.0306 0.0995 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0014 0.0014
Schistosoma mansoni vesicular acetylcholine transporter 0.2449 0.826 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Brugia malayi Thioredoxin reductase 0.0047 0.0118 0.0118
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.0157 0.019
Echinococcus multilocularis neuropeptide receptor A26 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Brugia malayi G-protein coupled receptor 0.0058 0.0157 0.0157
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0014 0.0456
Toxoplasma gondii hypothetical protein 0.004 0.0094 0.2978
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0014
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0321 0.3227
Loa Loa (eye worm) hypothetical protein 0.2962 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Onchocerca volvulus 0.003 0.006 0.0072
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Echinococcus multilocularis glutamate receptor 2 0.0023 0.0036 0.0043
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0014 0.0014
Onchocerca volvulus 0.004 0.0094 0.0114
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0157 0.019
Schistosoma mansoni neuropeptide receptor 0.0058 0.0157 0.019
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0012
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0321 0.3227
Echinococcus multilocularis G protein coupled receptor 139 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus glutamate receptor subunit protein glur 0.0015 0.001 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.0157 0.0157
Brugia malayi hypothetical protein 0.0058 0.0157 0.0157
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 0.0157 0.019
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 0.0157 0.019
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0085 0.0954
Echinococcus multilocularis allatostatin A receptor 0.0058 0.0157 0.019
Echinococcus multilocularis sex peptide receptor 0.0058 0.0157 0.019
Plasmodium vivax amine transporter, putative 0.004 0.0094 0.7834
Brugia malayi hypothetical protein 0.004 0.0094 0.0094
Plasmodium vivax glutathione reductase, putative 0.0047 0.0118 1
Schistosoma mansoni sodium/chloride dependent transporter 0.004 0.0094 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.006 0.0072
Echinococcus granulosus neuropeptide receptor A26 0.0058 0.0157 0.019
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0089 0.1009
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.0157 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.0316 0.0316
Toxoplasma gondii exonuclease III APE 0.0037 0.0085 0.2687
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0157 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.004 0.0094 0.0094
Schistosoma mansoni biogenic amine receptor 0.0058 0.0157 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Schistosoma mansoni hypothetical protein 0.0058 0.0157 0.019
Echinococcus granulosus adenosine kinase 0.0105 0.0316 0.0382
Schistosoma mansoni glutamate receptor AMPA 0.0015 0.001 0.0012
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0085 0.0852
Loa Loa (eye worm) serotonin transporter b 0.0234 0.0752 0.0752
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0118 0.1186
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0056 0.0068
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 0.0157 0.019
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.0157 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2449 0.826 1
Echinococcus multilocularis glutamate receptor 2 0.0015 0.001 0.0012
Plasmodium vivax hypothetical protein, conserved 0.004 0.0094 0.7834
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni ap endonuclease 0.0037 0.0085 0.0103
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0658 0.0658
Echinococcus multilocularis sphingosine kinase 1 0.0306 0.0995 0.1205
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0003
Echinococcus granulosus vesicular acetylcholine transporter 0.2449 0.826 1
Echinococcus granulosus neuropeptide s receptor 0.0058 0.0157 0.019
Echinococcus multilocularis fmrfamide receptor 0.0058 0.0157 0.019
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0157 0.019
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0362 0.3633
Echinococcus multilocularis dna polymerase eta 0.0019 0.0023 0.0028
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Brugia malayi follicle stimulating hormone receptor 0.0282 0.0916 0.0916
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.0157 0.019
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0085 0.0852
Loa Loa (eye worm) hypothetical protein 0.0058 0.0157 0.0157
Brugia malayi putative neuropeptide receptor 0.0058 0.0157 0.0157
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.004 0.0094 0.0114
Schistosoma mansoni hypothetical protein 0.0154 0.0483 0.0585
Echinococcus granulosus orexin receptor type 2 0.0058 0.0157 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0234 0.0752 0.0752
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.004 0.0094 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0176 0.0555 0.0672
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0157 0.019
Echinococcus granulosus somatostatin receptor 0.0058 0.0157 0.019
Trypanosoma brucei unspecified product 0.0019 0.0023 0.0023
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.0157 0.0157
Echinococcus granulosus tm gpcr rhodopsin 0.111 0.3721 0.4505
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.003 0.0396
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0085 0.1125

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6 nM Evaluated in vitro for inhibitory activity against Adenosine kinase (AK) ChEMBL. 12166937
IC50 (binding) = 6 nM Evaluated in vitro for inhibitory activity against Adenosine kinase (AK) ChEMBL. 12166937
IC50 (functional) = 94 nM Evaluated in vitro for the inhibition of Adenosine (ADO) phosphorylation in intact IMR-32 human neuroblastoma cells. ChEMBL. 12166937
IC50 (functional) = 94 nM Evaluated in vitro for the inhibition of Adenosine (ADO) phosphorylation in intact IMR-32 human neuroblastoma cells. ChEMBL. 12166937
NA (functional) 0 Nociceptive paw flinching in rats assessed 30 min following an intraplantar injection of 5% formalin into the right hindpaw; NA=not active microM/Kg ChEMBL. 12166937
NA (functional) 0 Antihyperalgesic effect in the carrageenan induced thermal hyperalgesia model microM/Kg ChEMBL. 12166937

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 12166937

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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