Detailed information for compound 213410

Basic information

Technical information
  • TDR Targets ID: 213410
  • Name: N-(cyanomethyl)-2-[3-[4-(4-methylpiperazin-1- yl)phenyl]phenyl]-3-phenylpropanamide
  • MW: 438.564 | Formula: C28H30N4O
  • H donors: 1 H acceptors: 2 LogP: 4.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCNC(=O)C(c1cccc(c1)c1ccc(cc1)N1CCN(CC1)C)Cc1ccccc1
  • InChi: 1S/C28H30N4O/c1-31-16-18-32(19-17-31)26-12-10-23(11-13-26)24-8-5-9-25(21-24)27(28(33)30-15-14-29)20-22-6-3-2-4-7-22/h2-13,21,27H,15-20H2,1H3,(H,30,33)
  • InChiKey: MILUUTXLDNUOSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(cyanomethyl)-2-[3-[4-(4-methylpiperazin-1-yl)phenyl]phenyl]-3-phenyl-propanamide
  • N-(cyanomethyl)-2-[3-[4-(4-methyl-1-piperazinyl)phenyl]phenyl]-3-phenylpropanamide
  • N-(cyanomethyl)-2-[3-[4-(4-methylpiperazino)phenyl]phenyl]-3-phenyl-propionamide
  • N-(cyanomethyl)-2-[3-[4-(4-methylpiperazin-1-yl)phenyl]phenyl]-3-phenyl-propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References
Homo sapiens cathepsin L Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0086 0.0924 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0086 0.0924 0.1341
Loa Loa (eye worm) hypothetical protein 0.0471 0.6892 1
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Onchocerca volvulus 0.0086 0.0924 1
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0039 0.0202 0.0077
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0039 0.0202 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0039 0.0202 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Plasmodium vivax unspecified product 0.0047 0.0316 0.3366
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0048 0.0345 0.3729
Schistosoma mansoni NAD dehydrogenase 0.0039 0.0202 0.0202
Plasmodium vivax vivapain-2 0.0086 0.0924 1
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0471 0.6892 1
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Onchocerca volvulus 0.0086 0.0924 1
Echinococcus multilocularis synaptic glycoprotein sc2 0.0065 0.0598 0.0598
Brugia malayi Cathepsin L-like precursor 0.0086 0.0924 0.1372
Echinococcus granulosus cathepsin L cysteine protease 0.0047 0.0316 0.0316
Brugia malayi eukaryotic initiation factor 4A 0.0048 0.0345 0.0512
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.007 0.0673 0.0793
Echinococcus multilocularis cysteine protease 0.0086 0.0924 0.0924
Onchocerca volvulus 0.0086 0.0924 1
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0316 0.0251
Brugia malayi cDNA sequence BC016226 0.0039 0.0202 0.0299
Brugia malayi Cathepsin L-like precursor 0.0059 0.051 0.0757
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1614 0.2342
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0598 0.0679
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0924 0.1174
Brugia malayi Cathepsin L-like precursor 0.0086 0.0924 0.1372
Giardia lamblia Synaptic glycoprotein SC2 0.0065 0.0598 0.8561
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0039 0.0202 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0011
Onchocerca volvulus 0.0059 0.051 0.5515
Schistosoma mansoni hypothetical protein 0.0117 0.14 0.14
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0924 0.0924
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.0598 0.0606
Plasmodium vivax vivapain-1 0.0047 0.0316 0.3366
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0047 0.0316 0.0459
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0924 0.0924
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2396 0.2396
Schistosoma mansoni cathepsin s 0.0027 0.0008 0.0008
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0316 0.0459
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0924 0.1362
Echinococcus granulosus cathepsin b 0.0181 0.2396 0.2396
Entamoeba histolytica cysteine proteinase 2 0.0047 0.0316 0.0251
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0181 0.2396 0.2396
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0065 0.0598 0.0598
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.007 0.0673 0.0989
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0048 0.0345 0.0294
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0924 0.0924
Loa Loa (eye worm) hypothetical protein 0.0181 0.2396 0.3476
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0461 0.6736 1
Echinococcus multilocularis cathepsin b 0.0181 0.2396 0.2396
Onchocerca volvulus Cathepsin F homolog 0.0086 0.0924 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0598 0.0679
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0316 0.0251
Entamoeba histolytica cysteine protease, putative 0.0086 0.0924 0.1174
Brugia malayi RE18450p 0.0039 0.0202 0.0299
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0924 0.1362
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0461 0.6736 1
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0011
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1614 0.2342
Giardia lamblia Cathepsin B precursor 0.007 0.0673 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0151 0.0219
Brugia malayi Cathepsin L-like precursor 0.0086 0.0924 0.1372
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.051 0.0757
Loa Loa (eye worm) cathepsin B 0.007 0.0673 0.0977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0293
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0048 0.0345 0.0294
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0048 0.0345 0.0219
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0065 0.0598 0.0606
Leishmania major eukaryotic initiation factor 4a, putative 0.0048 0.0345 0.0294
Leishmania major eukaryotic initiation factor 4a, putative 0.0048 0.0345 0.0294
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0048 0.0345 0.0235
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0039 0.0202 0.2182
Leishmania major hypothetical protein, conserved 0.0039 0.0202 0.0077
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0181 0.2396 0.3549
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0151 0.0151
Brugia malayi Cathepsin L-like precursor 0.0059 0.051 0.0757
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0151 0.0151
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0151 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Loa Loa (eye worm) hypothetical protein 0.0059 0.051 0.074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Trypanosoma cruzi cysteine protease, putative 0.0047 0.0316 0.0459
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0151 0.0151
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0316 0.0316
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0039 0.0202 0.0202
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0461 0.6736 1
Mycobacterium ulcerans hypothetical protein 0.0461 0.6736 0.9767
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0039 0.0202 0.0971
Loa Loa (eye worm) hypothetical protein 0.0059 0.051 0.074
Brugia malayi cathepsin B-like cysteine proteinase 0.0181 0.2396 0.3556
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0039 0.0202 0.0288
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0598 0.6439
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0039 0.0202 0.0299
Schistosoma mansoni microtubule-associated protein tau 0.0671 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.051 0.051
Brugia malayi Cathepsin L-like precursor 0.0086 0.0924 0.1372
Leishmania major hypothetical protein, conserved 0.0039 0.0202 0.0077
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0598 0.0679
Echinococcus multilocularis cathepsin L 0.0047 0.0316 0.0316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Giardia lamblia Cathepsin B precursor 0.007 0.0673 1
Echinococcus granulosus synaptic glycoprotein sc2 0.0065 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0086 0.0924 0.1341
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0598 0.0679
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0048 0.0345 0.0501
Onchocerca volvulus 0.0065 0.0598 0.647
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0461 0.6736 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0151 0.0224
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0461 0.6736 1
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0151 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0086 0.0924 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0924 0.1341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0598 0.0877
Brugia malayi Synaptic glycoprotein SC2 0.0065 0.0598 0.0888
Entamoeba histolytica hypothetical protein 0.0065 0.0598 0.0679
Plasmodium vivax RNA helicase-1, putative 0.0048 0.0345 0.3675
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.007 0.0673 0.0793
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Loa Loa (eye worm) hypothetical protein 0.0048 0.0345 0.05
Brugia malayi Papain family cysteine protease containing protein 0.0086 0.0924 0.1372
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0293
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0039 0.0202 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.007 0.0673 0.0673
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0316 0.0251
Trypanosoma cruzi cysteine proteinase, putative 0.0047 0.0316 0.0459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Onchocerca volvulus 0.0086 0.0924 1
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0316 0.047
Brugia malayi Cathepsin L-like precursor 0.0086 0.0924 0.1372
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0048 0.0345 0.0345
Echinococcus multilocularis geminin 0.0165 0.2149 0.2149
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.051 0.0746
Brugia malayi cathepsin F-like cysteine proteinase 0.0027 0.0008 0.0012
Echinococcus granulosus geminin 0.0165 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0461 0.6736 0.9774
Giardia lamblia Cathepsin B precursor 0.007 0.0673 1
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0039 0.0202 0.0077
Echinococcus granulosus cathepsin l1 0.0059 0.051 0.051
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0598 0.0679
Brugia malayi MH2 domain containing protein 0.013 0.1614 0.2396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Plasmodium falciparum polyprenol reductase, putative 0.0065 0.0598 0.5484
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0048 0.0345 0.0345
Toxoplasma gondii cathepsin CPL 0.0086 0.0924 0.1106
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0039 0.0202 0.0077
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0151 0.0151
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0039 0.0202 0.0077
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0598 0.0679
Echinococcus multilocularis cathepsin b 0.0181 0.2396 0.2396
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0039 0.0202 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Treponema pallidum ATP-dependent RNA helicase 0.0048 0.0345 0.5
Brugia malayi Cathepsin L-like precursor 0.0086 0.0924 0.1372
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0011
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0048 0.0345 0.0294
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.0598 0.0598
Loa Loa (eye worm) cysteine protease 0.0086 0.0924 0.1341
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0924 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Plasmodium falciparum cysteine proteinase falcipain 1 0.0047 0.0316 0.1587
Toxoplasma gondii cathepsin B 0.007 0.0673 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0065 0.0598 0.0679
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0065 0.0598 0.0868
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.051 0.0545
Schistosoma mansoni hypothetical protein 0.0165 0.2149 0.2149
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0039 0.0202 0.0202
Schistosoma mansoni fad oxidoreductase 0.0039 0.0202 0.0202
Schistosoma mansoni hypothetical protein 0.0165 0.2149 0.2149
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Echinococcus multilocularis microtubule associated protein 2 0.0671 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0086 0.0924 1
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0924 0.1174
Loa Loa (eye worm) ctsf protein 0.0086 0.0924 0.1341
Echinococcus granulosus cysteine protease 0.0047 0.0316 0.0316
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0047 0.0316 0.0251
Plasmodium falciparum eukaryotic initiation factor 4A 0.0048 0.0345 0.1979
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Brugia malayi Papain family cysteine protease containing protein 0.0047 0.0316 0.047
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0461 0.6736 1
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0039 0.0202 0.0288
Plasmodium vivax vivapain-2 0.0086 0.0924 1
Echinococcus granulosus eukaryotic initiation factor 4A 0.0048 0.0345 0.0345
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0048 0.0345 0.0345
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0432 0.6283 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0048 0.0345 0.0345
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0039 0.0202 0.0299
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0039 0.0202 0.0288
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0039 0.0202 0.0288
Brugia malayi cathepsin L-like precursor 0.0059 0.051 0.0757
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0065 0.0598 0.0598
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0048 0.0345 0.3709
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0039 0.0202 0.0288
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0471 0.6892 1
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0065 0.0598 0.5484
Entamoeba histolytica cysteine proteinase, putative 0.0086 0.0924 0.1174
Onchocerca volvulus 0.0086 0.0924 1
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0039 0.0202 0.0288
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0316 0.0251
Leishmania major cysteine peptidase A (CPA) 0.0086 0.0924 0.1174
Loa Loa (eye worm) fibroinase 0.0086 0.0924 0.1341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.051 0.0545
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0048 0.0345 0.0501
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0151 0.0151
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0065 0.0598 0.0679
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0086 0.0924 1
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0039 0.0202 0.2182
Loa Loa (eye worm) hypothetical protein 0.0059 0.051 0.074
Plasmodium vivax polyprenol reductase, putative 0.0065 0.0598 0.6439
Schistosoma mansoni fad oxidoreductase 0.0039 0.0202 0.0202
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Plasmodium vivax vivapain-3 0.0047 0.0316 0.3366
Trypanosoma brucei RNA helicase, putative 0.0117 0.14 0.1897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0316 0.0251
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0048 0.0345 0.0345
Echinococcus granulosus cathepsin l cysteine peptidase 0.0086 0.0924 0.0924
Echinococcus granulosus cathepsin b 0.0181 0.2396 0.2396
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0065 0.0598 0.0598
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0039 0.0202 0.2115
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0039 0.0202 0.0288
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2396 0.2396
Echinococcus granulosus cathepsin L cysteine proteinase 0.0086 0.0924 0.0924
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0048 0.0345 0.0294
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0086 0.0924 0.1174
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0461 0.6736 1
Trypanosoma cruzi cysteine peptidase, putative 0.0047 0.0316 0.0459
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.0293
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0065 0.0598 0.0679
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0924 0.1362
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0461 0.6736 1
Onchocerca volvulus 0.0086 0.0924 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0048 0.0345 0.0294
Trypanosoma brucei cysteine peptidase C (CPC) 0.007 0.0673 0.0793
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0924 0.1362
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0151 0.0213
Chlamydia trachomatis D-amino acid dehydrogenase 0.0039 0.0202 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0047 0.0316 0.0251
Leishmania major cathepsin L-like protease 0.0086 0.0924 0.1174
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0047 0.0316 0.0316
Schistosoma mansoni d-amino acid oxidase 0.0471 0.6892 0.6892
Brugia malayi Cathepsin L-like precursor 0.0027 0.0008 0.0012
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0181 0.2396 0.2396
Onchocerca volvulus Putative fad oxidoreductase 0.0039 0.0202 0.2182
Echinococcus granulosus cathepsin l1 0.0086 0.0924 0.0924
Echinococcus granulosus cathepsin L 0.0047 0.0316 0.0316
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0027 0.0008 0.0011
Onchocerca volvulus Cathepsin L homolog 0.0086 0.0924 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0047 0.0316 0.0251
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0461 0.6736 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0086 0.0924 1
Entamoeba histolytica cysteine protease, putative 0.0047 0.0316 0.0251
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0086 0.0924 0.1174
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0461 0.6736 1
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0065 0.0598 0.0868
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0151 0.0151
Schistosoma mansoni cathepsin F (C01 family) 0.0086 0.0924 0.0924
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0924 0.1362
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0086 0.0924 0.0924
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0086 0.0924 0.1174
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0027 0.0008 0.0012
Echinococcus multilocularis cysteine protease 0.0086 0.0924 0.0924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.051 0.0545
Entamoeba histolytica cysteine proteinase, putative 0.0047 0.0316 0.0251
Echinococcus multilocularis cathepsin L cysteine protease 0.0086 0.0924 0.0924
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0039 0.0202 0.0293

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1405 nM In vitro inhibitory activity against human cathepsin K, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 1405 nM In vitro inhibitory activity against human cathepsin K, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 3907 nM In vitro inhibitory activity against human cathepsin L, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) = 3907 nM In vitro inhibitory activity against human cathepsin L, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin S, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin B, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin S, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076
IC50 (binding) > 10000 nM In vitro inhibitory activity against human cathepsin B, using 2 microM of Z -Leu-Arg-AMC as substrate ChEMBL. 12904076

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.