TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 208.146 | Formula: C13H20O2
H donors: 0 H acceptors: 1 LogP: 3.14 Rotable bonds: 3
Rule of 5 violations (Lipinski): 0
SMILES: CCOC(=O)C1CC2[C@@H](C1)[C@H]1C[C@H]2CC1
InChi: InChI=1S/C13H20O2/c1-2-15-13(14)10-6-11-8-3-4-9(5-8)12(11)7-10/h8-12H,2-7H2,1H3/t8-,9-,10?,11+,12?/m1/s1
InChiKey: MOGRTXHBIPWFGN-GRGSRKJBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0025	0.004	0.004
Echinococcus granulosus	cathepsin b	0.0281	0.3046	0.3046
Onchocerca volvulus		0.0031	0.0111	0.0654
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0595	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0081	0.0082
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0047	0.0302	0.0302
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Schistosoma mansoni	hypothetical protein	0.0029	0.0081	0.0081
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0025	0.004	0.004
Brugia malayi	Raf kinase	0.0826	0.9444	1
Echinococcus granulosus	jumonji domain containing protein	0.004	0.0213	0.0213
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0111	0.0363
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.2714	1
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Echinococcus granulosus	protein kinase c eta type	0.0047	0.0302	0.0302
Schistosoma mansoni	tyrosine kinase	0.0255	0.2745	0.2745
Echinococcus granulosus	cathepsin L cysteine protease	0.0031	0.0111	0.0111
Loa Loa (eye worm)	MBCTL1	0.0053	0.037	0.0374
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0111	0.2706
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0166	0.1694	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0053	0.037	0.0374
Brugia malayi	Protein kinase domain containing protein	0.0025	0.004	0.0042
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.0111	0.0654
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0152	0.0154
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0111	0.0111
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Toxoplasma gondii	diacylglycerol kinase, putative	0.0047	0.0302	0.3357
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.0111	0.0111
Echinococcus multilocularis	cathepsin L	0.0031	0.0111	0.0111
Brugia malayi	RhoGAP domain containing protein	0.0047	0.0302	0.032
Echinococcus multilocularis	jumonji domain containing protein	0.004	0.0213	0.0213
Schistosoma mansoni	diacylglycerol kinase theta	0.0047	0.0302	0.0302
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0025	0.004	0.004
Schistosoma mansoni	protein kinase C mu	0.0048	0.0308	0.0308
Entamoeba histolytica	diacylglycerol kinase, putative	0.0047	0.0302	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0294	0.0298
Schistosoma mansoni	vav2	0.0047	0.0302	0.0302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Plasmodium vivax	vivapain-3	0.0031	0.0111	1
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0047	0.0302	0.0305
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0156	0.1582	0.1675
Brugia malayi	Protein kinase domain containing protein	0.0048	0.0308	0.0326
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0081	0.0904
Echinococcus multilocularis	epidermal growth factor receptor	0.032	0.3503	0.3503
Echinococcus granulosus	Rac GTPase activating protein 1	0.0047	0.0302	0.0302
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0047	0.0302	0.0302
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0111	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.004	0.004
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0025	0.004	0.004
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0022	0	0.5
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0307	0.3349	1
Plasmodium vivax	unspecified product	0.0031	0.0111	1
Onchocerca volvulus	Alhambra homolog	0.0029	0.0081	0.048
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0025	0.004	0.004
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.037	0.0392
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.2714	1
Echinococcus granulosus	protein tyrosine kinase	0.0255	0.2745	0.2745
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0047	0.0302	0.0305
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0031	0.0111	1
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0306	0.3346	0.3383
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0487	0.5469	0.5529
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0098	0.09	0.09
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0111	0.0117
Echinococcus multilocularis	geminin	0.0166	0.1694	0.1694
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0025	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Loa Loa (eye worm)	cathepsin B	0.0098	0.09	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Onchocerca volvulus		0.0047	0.0302	0.1783
Brugia malayi	p70 ribosomal S6 kinase beta	0.0025	0.004	0.0042
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0025	0.004	0.004
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0111	0.0111
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0307	0.3349	1
Schistosoma mansoni	rac gtpase activating protein	0.0047	0.0302	0.0302
Echinococcus multilocularis	N chimaerin	0.0047	0.0302	0.0302
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0111	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0308	0.0308
Loa Loa (eye worm)	PHD-finger family protein	0.0029	0.0081	0.0082
Loa Loa (eye worm)	ctsf protein	0.0031	0.0111	0.0112
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.032	0.3503	0.3503
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0111	0.2706
Schistosoma mansoni	tyrosine kinase	0.031	0.3393	0.3393
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0025	0.004	0.004
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0438	0.0443
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0048	0.0308	0.0308
Brugia malayi	RhoGEF domain containing protein	0.0047	0.0302	0.032
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0111	0.2706
Schistosoma mansoni	jumonji domain containing protein	0.0074	0.0618	0.0618
Brugia malayi	protein kinase C3,putative	0.0289	0.3138	0.3323
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.2714	1
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0281	0.3046	0.3046
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0793	0.9065	0.9065
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0111	0.2706
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.0111	0.0363
Loa Loa (eye worm)	raf kinase	0.0864	0.9891	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0294	0.1739
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0308	0.0308
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0031	0.0111	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Toxoplasma gondii	cathepsin B	0.0098	0.09	1
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0184	0.1906	0.1906
Brugia malayi	Ras association domain family 1 isoform A	0.0047	0.0302	0.032
Brugia malayi	diacylglycerol kinase	0.0047	0.0302	0.032
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.2714	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0031	0.0111	1
Brugia malayi	jmjC domain containing protein	0.0093	0.0844	0.0893
Echinococcus multilocularis	cysteine protease	0.0031	0.0111	0.0111
Entamoeba histolytica	hypothetical protein	0.0047	0.0302	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Plasmodium falciparum	phd finger protein, putative	0.0029	0.0081	0.7348
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0281	0.3046	1
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Echinococcus multilocularis	protein kinase c eta type	0.0047	0.0302	0.0302
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Giardia lamblia	Cathepsin B precursor	0.0098	0.09	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.037	0.037
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0022	0	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0029	0.0081	0.0081
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0025	0.004	0.004
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0281	0.3046	0.3046
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0048	0.0308	0.0308
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0285	0.3095	1
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0111	0.2706
Brugia malayi	jmjC domain containing protein	0.0035	0.0152	0.0161
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.004	0.004
Brugia malayi	Bromodomain containing protein	0.0029	0.0081	0.0086
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0072	0.0595	0.0602
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0025	0.004	0.004
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0047	0.0302	0.0302
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0047	0.0302	0.0302
Echinococcus multilocularis	lysine specific demethylase 5A	0.0035	0.0152	0.0152
Brugia malayi	Variant SH3 domain containing protein	0.0047	0.0302	0.032
Schistosoma mansoni	hypothetical protein	0.0047	0.0302	0.0302
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0025	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Toxoplasma gondii	AGC kinase	0.0025	0.004	0.0442
Plasmodium vivax	hypothetical protein, conserved	0.0029	0.0081	0.7348
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0031	0.0111	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.2714	1
Echinococcus granulosus	protein kinase c iota type	0.0313	0.3425	0.3425
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0294	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Brugia malayi	Protein kinase c protein 2	0.0048	0.0308	0.0326
Loa Loa (eye worm)	cysteine protease	0.0031	0.0111	0.0112
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0029	0.0081	0.0081
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0193	0.2009	0.2009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Schistosoma mansoni	unc-13 (munc13)	0.0047	0.0302	0.0302
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0281	0.3046	0.3046
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0098	0.09	0.2953
Trypanosoma cruzi	cysteine protease, putative	0.0031	0.0111	0.0363
Echinococcus granulosus	cathepsin L	0.0031	0.0111	0.0111
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0031	0.0111	0.0112
Brugia malayi	diacylglycerol kinase	0.0047	0.0302	0.032
Schistosoma mansoni	tyrosine kinase	0.059	0.6677	0.6677
Echinococcus multilocularis	myotubularin protein 13	0.0047	0.0302	0.0302
Echinococcus multilocularis	unc 13 (munc13)	0.0047	0.0302	0.0302
Schistosoma mansoni	tyrosine kinase	0.0193	0.2009	0.2009
Schistosoma mansoni	tyrosine kinase	0.031	0.3393	0.3393
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Echinococcus multilocularis		0.0181	0.187	0.187
Onchocerca volvulus	Cathepsin L homolog	0.0031	0.0111	0.0654
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0294	0.0294
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0111	0.0111
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0048	0.0308	0.0326
Onchocerca volvulus		0.0031	0.0111	0.0654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Onchocerca volvulus		0.0031	0.0111	0.0654
Schistosoma mansoni	diacylglycerol kinase theta	0.0047	0.0302	0.0302
Schistosoma mansoni	unc-13 (munc13)	0.0047	0.0302	0.0302
Schistosoma mansoni	serine/threonine kinase	0.0025	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Loa Loa (eye worm)	TK/EGFR protein kinase	0.059	0.6677	0.6751
Brugia malayi	RhoGAP domain containing protein	0.0047	0.0302	0.032
Echinococcus granulosus	insulin receptor	0.0193	0.2009	0.2009
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Echinococcus granulosus	PHD finger protein rhinoceros	0.0029	0.0081	0.0081
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Echinococcus granulosus	cathepsin l1	0.0031	0.0111	0.0111
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0294	0.0294
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Echinococcus multilocularis	protein kinase c epsilon type	0.0072	0.0595	0.0595
Echinococcus multilocularis	epidermal growth factor receptor	0.059	0.6677	0.6677
Onchocerca volvulus		0.0047	0.0302	0.1783
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Trichomonas vaginalis	glucosylceramidase, putative	0.0253	0.2714	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0025	0.004	0.004
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0047	0.0302	0.0302
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Onchocerca volvulus	Cathepsin F homolog	0.0031	0.0111	0.0654
Brugia malayi	Hr1 repeat family protein	0.0025	0.004	0.0042
Onchocerca volvulus	Tyrosine kinase homolog	0.0147	0.1467	0.8664
Schistosoma mansoni	protein kinase C mu	0.0047	0.0302	0.0302
Loa Loa (eye worm)	fibroinase	0.0031	0.0111	0.0112
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0111	0.0117
Echinococcus granulosus	epidermal growth factor receptor	0.032	0.3503	0.3503
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.1798	0.6584
Entamoeba histolytica	cysteine proteinase 1, putative	0.0031	0.0111	0.2706
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.004	0.004
Onchocerca volvulus		0.0047	0.0294	0.1739
Trypanosoma cruzi	cysteine proteinase, putative	0.0031	0.0111	0.0363
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0595	0.0595
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Brugia malayi	Furin-like cysteine rich region family protein	0.059	0.6677	0.707
Echinococcus granulosus	protein kinase C gamma type	0.0025	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.0111	0.0288
Brugia malayi	Protein kinase domain containing protein	0.0193	0.2009	0.2127
Echinococcus granulosus	cysteine protease	0.0031	0.0111	0.0111
Toxoplasma gondii	PHD-finger domain-containing protein	0.0029	0.0081	0.0904
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Echinococcus granulosus	Protein kinase C brain isozyme	0.0072	0.0595	0.0595
Plasmodium vivax	vivapain-2	0.0031	0.0111	1
Echinococcus multilocularis	cathepsin b	0.0281	0.3046	0.3046
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0047	0.0302	0.0305
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0098	0.09	0.3231
Trypanosoma cruzi	cruzipain precursor, putative	0.0031	0.0111	0.0363
Schistosoma mansoni	tyrosine kinase	0.031	0.3393	0.3393
Schistosoma mansoni	atypical protein kinase C	0.0331	0.3633	0.3633
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0098	0.09	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0031	0.0111	0.0363
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0253	0.2714	0.2874
Brugia malayi	Pleckstrin Homology Domain	0.0047	0.0302	0.032
Entamoeba histolytica	cysteine proteinase 2	0.0031	0.0111	0.2706
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0111	0.0363
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0025	0.004	0.004
Schistosoma mansoni	cathepsin F (C01 family)	0.0031	0.0111	0.0111
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0047	0.0302	0.0302
Brugia malayi	Protein kinase domain containing protein	0.0025	0.004	0.0042
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.037	0.037
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0025	0.004	0.004
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.037	0.037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Brugia malayi	mbt repeat family protein	0.0047	0.0294	0.0312
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0111	0.0117
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Echinococcus granulosus	geminin	0.0166	0.1694	0.1694
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0111	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0184	0.1906	0.1906
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.004	0.004
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Schistosoma mansoni	tyrosine kinase	0.032	0.3503	0.3503
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0294	0.0298
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Entamoeba histolytica	cysteine proteinase, putative	0.0031	0.0111	0.2706
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0321	0.0324
Brugia malayi	protein kinase C II.	0.0072	0.0595	0.063
Echinococcus multilocularis	cysteine protease	0.0031	0.0111	0.0111
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0253	0.2714	0.2744
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0111	0.0363
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0031	0.0111	0.0825
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0294	0.0294
Echinococcus granulosus	peregrin	0.0029	0.0081	0.0081
Echinococcus multilocularis	insulin receptor	0.0193	0.2009	0.2009
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0093	0.0844	0.0844
Giardia lamblia	Cathepsin B precursor	0.0098	0.09	1
Leishmania major	cysteine peptidase A (CPA)	0.0031	0.0111	0.123
Echinococcus granulosus	epidermal growth factor receptor	0.059	0.6677	0.6677
Brugia malayi	cathepsin B-like cysteine proteinase	0.0281	0.3046	0.3225
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Loa Loa (eye worm)	hypothetical protein	0.0281	0.3046	0.308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0031	0.0111	0.0111
Schistosoma mansoni	serine/threonine protein kinase	0.0873	1	1
Schistosoma mansoni	hypothetical protein	0.0166	0.1694	0.1694
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0873	1	1
Giardia lamblia	Cathepsin B precursor	0.0098	0.09	1
Plasmodium vivax	vivapain-2	0.0031	0.0111	1
Brugia malayi	mbt repeat family protein	0.0047	0.0294	0.0312
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0047	0.0302	0.0302
Echinococcus multilocularis	cathepsin L cysteine protease	0.0031	0.0111	0.0111
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0047	0.0302	0.0302
Entamoeba histolytica	diacylglycerol kinase, putative	0.0047	0.0302	1
Echinococcus multilocularis	serine threonine protein kinase	0.0025	0.004	0.004
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Onchocerca volvulus		0.0031	0.0111	0.0654
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0031	0.0111	1
Onchocerca volvulus		0.0047	0.0302	0.1783
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Echinococcus multilocularis	protein kinase c iota type	0.0313	0.3425	0.3425
Echinococcus granulosus	N chimaerin	0.0047	0.0302	0.0302
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0047	0.0302	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0302	0.0305
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0031	0.0111	0.0111
Brugia malayi	Cathepsin L-like precursor	0.0031	0.0111	0.0117
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Schistosoma mansoni	hypothetical protein	0.0284	0.3079	0.3079
Plasmodium vivax	vivapain-1	0.0031	0.0111	1
Trichomonas vaginalis	AGC family protein kinase	0.0025	0.004	0.0024
Loa Loa (eye worm)	TK/INSR protein kinase	0.0193	0.2009	0.2031
Onchocerca volvulus		0.0135	0.1331	0.7856
Toxoplasma gondii	cathepsin CPL	0.0031	0.0111	0.123
Echinococcus granulosus	NDR protein kinase	0.0025	0.004	0.004
Brugia malayi	C1-like domain containing protein	0.0048	0.0308	0.0326
Brugia malayi	Protein kinase domain containing protein	0.0025	0.004	0.0042
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0048	0.0308	0.0312
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0156	0.1582	0.1599
Onchocerca volvulus		0.0031	0.0111	0.0654
Onchocerca volvulus		0.0031	0.0111	0.0654
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0025	0.004	0.004
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0072	0.0595	0.0595
Onchocerca volvulus		0.0031	0.0111	0.0654
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0031	0.0111	0.0288
Brugia malayi	PHD-finger family protein	0.0029	0.0081	0.0086
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Entamoeba histolytica	cysteine protease, putative	0.0031	0.0111	0.2706
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0294	0.0294
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0281	0.3046	0.3046
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Echinococcus multilocularis	peregrin	0.0029	0.0081	0.0081
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0031	0.0111	0.0112
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0098	0.09	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0152	0.0152
Schistosoma mansoni	tyrosine kinase	0.0193	0.2009	0.2009
Echinococcus granulosus	myotubularin protein 13	0.0047	0.0302	0.0302
Trypanosoma cruzi	cysteine peptidase, putative	0.0031	0.0111	0.0363
Echinococcus multilocularis	cathepsin b	0.0281	0.3046	0.3046
Loa Loa (eye worm)	TK/FAK protein kinase	0.0258	0.2779	0.281
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Echinococcus multilocularis	protein tyrosine kinase	0.0255	0.2745	0.2745
Echinococcus granulosus	protein kinase c epsilon type	0.0072	0.0595	0.0595
Schistosoma mansoni	serine/threonine protein kinase	0.0072	0.0595	0.0595
Trichomonas vaginalis	glucosylceramidase, putative	0.0166	0.1694	0.6193
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Trichomonas vaginalis	glucosylceramidase, putative	0.0175	0.1798	0.6584
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0111	0.0117
Echinococcus granulosus	unc 13 munc13	0.0047	0.0302	0.0302
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0294	0.0294
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0093	0.0844	0.0844
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0031	0.0111	0.0288
Echinococcus granulosus	serine:threonine protein kinase N2	0.0025	0.004	0.004
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0031	0.0111	0.0111
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0111	0.0117
Brugia malayi	Papain family cysteine protease containing protein	0.0031	0.0111	0.0117
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0031	0.0111	0.0288
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0294	0.0294
Echinococcus granulosus	Diacylglycerol kinase theta	0.0047	0.0302	0.0302
Schistosoma mansoni	protein kinase C	0.0047	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0111	0.0112
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.037	0.037
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0025	0.004	0.004
Brugia malayi	Protein kinase domain containing protein	0.0258	0.2779	0.2943
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0025	0.004	0.004
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0152	0.0152
Leishmania major	cathepsin L-like protease	0.0031	0.0111	0.123
Onchocerca volvulus	Glucosylceramidase homolog	0.0166	0.1694	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.037	0.037
Echinococcus granulosus	cathepsin b	0.0281	0.3046	0.3046
Schistosoma mansoni	tyrosine kinase	0.032	0.3503	0.3503
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0193	0.2009	0.2009

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)		Inhibition of 2,6-dimethylpyrazine-induced odor assessed as strength of odor on cloth smelled by subjects	ChEMBL.	No reference
Inhibition (functional)	>= 40 %	Antagonist activity at human OR5K1 expressed in HEK293 cells assessed as inhibition of 2,6-dimethylpyrazine-induced response at 100 uM by luciferase reporter gene assay	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3731741

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2153465