Detailed information for compound 215540

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.808 | Formula: C11H11ClN3OS2-
  • H donors: 1 H acceptors: 1 LogP: 1.68 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC2=Nc3c(CN2C1)c1c(s3)CCSC1.[Cl-]
  • InChi: 1S/C11H11N3OS2.ClH/c15-9-4-14-3-6-7-5-16-2-1-8(7)17-10(6)13-11(14)12-9;/h1-5H2,(H,12,13,15);1H/p-1
  • InChiKey: TUVUFTCNKINDDB-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.0759 0.3821
Loa Loa (eye worm) MBCTL1 0.0058 0.0153 0.073
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0062 0.0282
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0127 0.061
Schistosoma mansoni hypothetical protein 0.0377 0.1329 0.7792
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0127 0.0599
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0268 0.0926 0.4664
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0058 0.0247
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0571
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0365 0.1824
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0207 0.1216
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0365 0.0658
Echinococcus multilocularis survival motor neuron protein 1 0.0552 0.1971 0.1966
Loa Loa (eye worm) hypothetical protein 0.0072 0.0204 0.0992
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0122
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0331 0.116 0.5868
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0119 0.0547
Loa Loa (eye worm) hypothetical protein 0.0051 0.0127 0.0599
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0365 0.1814
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0119 0.0112
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0055 0.0375
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0365 0.2142
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0926 0.7964
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0326 0.1614
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0012 0.0103
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0055 0.0375
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0035 0.0145
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0062 0.0055
Loa Loa (eye worm) hypothetical protein 0.0043 0.0099 0.046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0326 0.1602
Echinococcus multilocularis neuropeptide receptor A26 0.0491 0.1749 0.1743
Echinococcus granulosus cpg binding protein 0.0038 0.0079 0.0365
Echinococcus granulosus lamin dm0 0.006 0.0159 0.0777
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0053 0.0234
Onchocerca volvulus 0.0113 0.0354 0.3628
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0331 0.116 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0189 0.1539
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0046 0.0199
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0365 0.3079
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0021 0.0059
Trichomonas vaginalis set domain proteins, putative 0.0253 0.0872 0.7491
Loa Loa (eye worm) hypothetical protein 0.0552 0.1971 1
Brugia malayi Pre-SET motif family protein 0.0222 0.0759 0.3812
Echinococcus multilocularis cpg binding protein 0.0038 0.0079 0.0072
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0365
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0571
Schistosoma mansoni lamin 0.006 0.0159 0.0935
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0926 0.7964
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0571
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0062 0.0055
Echinococcus multilocularis neuropeptide s receptor 0.0491 0.1749 0.1743
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0119 0.0112
Chlamydia trachomatis phenylalanine--tRNA ligase subunit alpha 0.1498 0.5455 1
Onchocerca volvulus 0.0253 0.0872 1
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0365 0.3079
Schistosoma mansoni hypothetical protein 0.0377 0.1329 0.7792
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0119 0.0698
Loa Loa (eye worm) hypothetical protein 0.006 0.0159 0.0766
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0035 0.0029
Plasmodium falciparum phenylalanine--tRNA ligase 0.0129 0.0416 0.3525
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0331 0.116 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0268 0.0926 0.4672
Brugia malayi CXXC zinc finger family protein 0.0034 0.0064 0.0266
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0055 0.0375
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0012 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0077 0.036
Brugia malayi hypothetical protein 0.0037 0.0077 0.0334
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0365 0.3079
Schistosoma mansoni hypothetical protein 0.0312 0.1089 0.6384
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.006 0.0418
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0365 0.3079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0064 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0119 0.0698
Plasmodium falciparum phenylalanine--tRNA ligase 0.0161 0.0531 0.4526
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0055 0.0375
Schistosoma mansoni hypothetical protein 0.0113 0.0354 0.2078
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0331 0.116 0.6799
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.0587 0.6492
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0365 0.3079
Brugia malayi 6-phosphofructokinase 0.0115 0.0365 0.1803
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0111 0.035 0.2944
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0153 0.0146
Echinococcus granulosus lamin 0.006 0.0159 0.0777
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0153 0.0894
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0331 0.116 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0081 0.0376
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0365 0.315
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0055 0.0375
Loa Loa (eye worm) hypothetical protein 0.0058 0.0153 0.073
Brugia malayi mbt repeat family protein 0.0051 0.0127 0.0586
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0159 0.0766
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0331 0.116 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0153 0.0742
Loa Loa (eye worm) hypothetical protein 0.0047 0.0114 0.0534
Schistosoma mansoni survival motor neuron protein 0.0113 0.0354 0.2078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0119 0.0571
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0153 0.0146
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0331 0.116 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0055 0.0375
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0077 0.0454
Echinococcus granulosus zinc finger protein 0.0023 0.0024 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0119 0.0698
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0055 0.0088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0326 0.1602
Schistosoma mansoni intermediate filament proteins 0.006 0.0159 0.0935
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0012 0.0009
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0055 0.0375
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.1498 0.5455 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0127 0.012
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0055 0.0375
Schistosoma mansoni hypothetical protein 0.0037 0.0077 0.0454
Echinococcus multilocularis lamin 0.006 0.0159 0.0153
Loa Loa (eye worm) hypothetical protein 0.0331 0.116 0.5863
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0077 0.0071
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0007 0.004
Echinococcus granulosus dnaJ subfamily B 0.0479 0.1705 0.8646
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0081 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0062 0.0257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.006 0.0351
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0111 0.035 0.2944
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0055 0.0375
Echinococcus multilocularis lamin dm0 0.006 0.0159 0.0153
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0055 0.0375
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.1498 0.5455 1
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0365
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0127 0.0743
Schistosoma mansoni cpg binding protein 0.0038 0.0079 0.0461
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0012 0.0026
Loa Loa (eye worm) intermediate filament protein 0.006 0.0159 0.0766
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0119 0.056
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0204 0.0979
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0113 0.0354 0.1748
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0153 0.0742
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Entamoeba histolytica hypothetical protein 0.0037 0.0077 0.0571
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0127 0.061
Plasmodium vivax SET domain protein, putative 0.0033 0.006 0.0418
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0111 0.035 0.2944
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0365 0.1814
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0103
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0012 0.0005
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0204 0.069 0.3476
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0055 0.0375
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0331 0.116 1
Brugia malayi hypothetical protein 0.0552 0.1971 1
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0331 0.116 0.5857
Echinococcus multilocularis dnaJ subfamily B 0.0479 0.1705 0.17
Schistosoma mansoni ap endonuclease 0.0019 0.0012 0.007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0181 0.0174
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0331 0.116 1
Echinococcus granulosus neuropeptide s receptor 0.0491 0.1749 0.8866
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0365
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0127 0.061
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0365 0.315
Brugia malayi 6-phosphofructokinase 0.0115 0.0365 0.1803
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0055 0.0375
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0153 0.0717
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.006 0.0351
Onchocerca volvulus 0.006 0.0159 0.1227
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0365 0.2142
Loa Loa (eye worm) hypothetical protein 0.0051 0.0127 0.0598
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0161 0.0531 0.3116
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0926 0.7964
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0365 0.0359
Brugia malayi intermediate filament protein 0.006 0.0159 0.0753
Schistosoma mansoni bromodomain containing protein 0.0069 0.0195 0.1142
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0167
Echinococcus multilocularis GPCR, family 2 0.0033 0.0062 0.0055
Onchocerca volvulus 0.0034 0.0064 0.0052
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0046 0.0039
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0062 0.027
Echinococcus multilocularis geminin 0.0377 0.1329 0.1323
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0365 0.315
Onchocerca volvulus 0.006 0.0159 0.1227
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0012 0.0103
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0161 0.0531 0.0525
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0127 0.012
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0159 0.0753
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0055 0.0375
Loa Loa (eye worm) hypothetical protein 0.0041 0.009 0.0413
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0161 0.0531 0.4526
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0055 0.0375
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0365 0.3079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0187
Loa Loa (eye worm) hypothetical protein 0.0075 0.0217 0.1057
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.022 0.075 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0062 0.0282
Schistosoma mansoni zinc finger protein 0.0023 0.0024 0.014
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0161 0.0531 0.2661
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0587 0.501
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0055 0.0088
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0331 0.116 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0055 0.0375
Schistosoma mansoni hypothetical protein 0.0072 0.0204 0.1195
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0127 0.0743
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0012 0.0103
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0331 0.116 0.1153
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0012 0.0009
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0127 0.012
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0127 0.0823
Echinococcus granulosus intermediate filament protein 0.006 0.0159 0.0777
Echinococcus multilocularis musashi 0.006 0.0159 0.0153
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0331 0.116 1
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0365 0.1814
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0622 0.5314
Echinococcus granulosus GPCR family 2 0.0033 0.0062 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0185 0.0622 0.5314
Brugia malayi Bromodomain containing protein 0.0082 0.0241 0.1167
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0926 0.7964
Brugia malayi PHD-finger family protein 0.0028 0.0045 0.0167
Loa Loa (eye worm) hypothetical protein 0.0105 0.0326 0.1614
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0204 0.069 0.0683
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0035 0.0208
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0365 0.0658
Onchocerca volvulus 0.0051 0.0127 0.0823
Brugia malayi mbt repeat family protein 0.0051 0.0127 0.0586
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0161 0.0531 0.4526
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0926 0.7964
Echinococcus multilocularis zinc finger protein 0.0023 0.0024 0.0017
Brugia malayi phosphofructokinase 0.0115 0.0365 0.1803
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.1498 0.5455 1
Trichomonas vaginalis glucosylceramidase, putative 0.0268 0.0926 0.7964
Schistosoma mansoni lamin 0.006 0.0159 0.0935
Schistosoma mansoni cpg binding protein 0.0034 0.0064 0.0376
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0365 0.3079
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0127 0.0743
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0007 0.004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0062 0.0257
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0365
Schistosoma mansoni cpg binding protein 0.0038 0.0079 0.0461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0119 0.0571
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0055 0.0375
Echinococcus granulosus neuropeptide receptor A26 0.0491 0.1749 0.8866
Brugia malayi Bromodomain containing protein 0.0041 0.009 0.0398
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0127 0.0742
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0111 0.035 0.2051
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0161 0.0531 0.2651
Brugia malayi Pre-SET motif family protein 0.0033 0.006 0.0245
Loa Loa (eye worm) hypothetical protein 0.0058 0.0155 0.0745
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0012 0.0014
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0365 0.3079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0127 0.0742
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0331 0.116 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0181 0.0885
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0161 0.0531 0.267
Schistosoma mansoni hypothetical protein 0.0479 0.1705 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0055 0.0375
Echinococcus granulosus geminin 0.0377 0.1329 0.6729
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0058 0.0233
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.006 0.0053
Echinococcus granulosus survival motor neuron protein 1 0.0552 0.1971 1

Activities

Activity type Activity value Assay description Source Reference
Delta A/min (functional) = 0 Ex vivo inhibition of collagen-induced blood platelet aggregation in rat was measured 2 hr after oral administration of 50 mg/kg ChEMBL. 7265124
Delta A/min (functional) = 100000 Ex vivo inhibition of ADP-induced blood platelet aggregation in rat was measured 2 hr after oral administration of 50 mg/kg ChEMBL. 7265124
Delta A/min (functional) = 150000 Ex vivo inhibition of ADP-induced blood platelet aggregation in rat was measured 2 hr after administration of vehical alone ChEMBL. 7265124
Delta A/min (functional) = 178000 Ex vivo inhibition of collagen-induced blood platelet aggregation in rat was measured 2 hr after administration of vehical alone ChEMBL. 7265124
EC50 (functional) = 0.54 uM In vitro inhibition of collagen-induced blood platelet aggregation ChEMBL. 7265124
EC50 (functional) = 2 uM In vitro inhibition of ADP-induced blood platelet aggregation ChEMBL. 7265124

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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