TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.47 | Formula: C16H27N3OS
H donors: 3 H acceptors: 1 LogP: 2.2 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC([C@@H](C(=O)Nc1cccc(c1)C)NC[C@H](CS)N)C
InChi: 1S/C16H27N3OS/c1-4-12(3)15(18-9-13(17)10-21)16(20)19-14-7-5-6-11(2)8-14/h5-8,12-13,15,18,21H,4,9-10,17H2,1-3H3,(H,19,20)/t12?,13-,15+/m1/s1
InChiKey: YCUUSGPXPIBQIQ-RLSDIYDTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Protein farnesyltransferase	Starlite/ChEMBL	References
Bos taurus	Geranylgeranyl transferase type I	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	geranylgeranyl transferase beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium knowlesi	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Neospora caninum	protein farnesyltranstransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_129786	All targets in OG5_129786
Schistosoma japonicum	ko:K05955 protein geranylgeranyltransferase type I, beta subunit [EC:2.5.1.59], putative	Get druggable targets OG5_129786	All targets in OG5_129786
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania major	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium berghei	protein farnesyltransferase subunit beta, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Theileria parva	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania donovani	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium falciparum	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma japonicum	ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania braziliensis	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei	protein farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Plasmodium vivax	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Candida albicans	beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)	Get druggable targets OG5_129786	All targets in OG5_129786
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium yoelii	Prenyltransferase and squalene oxidase repeat, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium vivax	farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Plasmodium knowlesi	conserved Plasmodium protein, unknown function	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania infantum	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Leishmania mexicana	farnesyltransferase beta subunit	Get druggable targets OG5_128081	All targets in OG5_128081
Babesia bovis	prenyltransferase and squalene oxidase repeat family protein	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	Get druggable targets OG5_129786	All targets in OG5_129786
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Giardia lamblia	Prenyltransferase	Get druggable targets OG5_128081	All targets in OG5_128081
Schistosoma mansoni	protein farnesyltransferase subunit beta	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	Get druggable targets OG5_128081	All targets in OG5_128081
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	Get druggable targets OG5_129786	All targets in OG5_129786
Candida albicans	beta subunit of C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p)	Get druggable targets OG5_129786	All targets in OG5_129786
Trypanosoma cruzi	protein farnesyltransferase, putative	Get druggable targets OG5_128081	All targets in OG5_128081

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	protein farnesyltransferase, putative	Geranylgeranyl transferase type I	377 aa	303 aa	28.4 %
Leishmania braziliensis	farnesyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	349 aa	24.9 %
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Geranylgeranyl transferase type I	377 aa	360 aa	24.2 %
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	Geranylgeranyl transferase type I	377 aa	357 aa	25.2 %
Dictyostelium discoideum	protein farnesyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	370 aa	27.3 %
Leishmania mexicana	farnesyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	340 aa	25.9 %
Onchocerca volvulus	FAD-linked sulfhydryl oxidase ALR homolog	Geranylgeranyl transferase type I	377 aa	319 aa	27.6 %
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	Geranylgeranyl transferase type I	377 aa	327 aa	28.7 %
Trypanosoma brucei gambiense	protein farnesyltransferase beta subunit, putative	Geranylgeranyl transferase type I	377 aa	361 aa	26.3 %
Schistosoma mansoni	protein farnesyltransferase subunit beta	Geranylgeranyl transferase type I	377 aa	381 aa	25.7 %
Candida albicans	similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote	Geranylgeranyl transferase type I	377 aa	378 aa	23.8 %
Cryptosporidium hominis	chain B, structure of fpt bound to ggpp	Geranylgeranyl transferase type I	377 aa	349 aa	25.5 %
Leishmania donovani	farnesyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	350 aa	26.3 %
Leishmania major	farnesyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	352 aa	26.1 %
Onchocerca volvulus		Geranylgeranyl transferase type I	377 aa	327 aa	28.1 %
Cryptosporidium parvum	protein geranyl-geranyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	349 aa	26.1 %
Trypanosoma brucei	protein farnesyltransferase beta subunit	Geranylgeranyl transferase type I	377 aa	361 aa	26.3 %
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	Geranylgeranyl transferase type I	377 aa	361 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	chromobox protein 1	0.0067	0.0374	0.0361
Trypanosoma brucei	transcription factor BTF3, putative	0.0032	0.0108	0.0413
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0086	0.0509	0.1478
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0138	0.0903	0.3087
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0047	0.0221	0.015
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0221	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0959	0.3417
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0221	0.0613
Plasmodium vivax	geranylgeranyltransferase, putative	0.0036	0.0145	0.0053
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0175	0.0263
Loa Loa (eye worm)	heterochromatin protein 1	0.0067	0.0374	0.1332
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0084	0.05	0.1304
Schistosoma mansoni	bromodomain containing protein	0.0061	0.0328	0.0315
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0245	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0555
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.005	0.0245	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0104	0.065	0.2316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0041	0.0001
Onchocerca volvulus		0.0146	0.0959	0.2776
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0138	0.0903	0.089
Echinococcus granulosus	casein kinase ii subunit beta	0.0084	0.05	0.0487
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0057	0.0294	0.0281
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0053	0.0269	0.0255
Plasmodium falciparum	casein kinase II beta chain	0.0084	0.05	0.0573
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0036	0.0145	0.1045
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0374	0.0361
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0086	0.0509	0.1478
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Plasmodium vivax	SET domain protein, putative	0.0057	0.0294	0.0271
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Plasmodium falciparum	casein kinase II beta chain	0.0084	0.05	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0104	0.065	0.2316
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.005	0.0245	0.0232
Toxoplasma gondii	hypothetical protein	0.0951	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0093	0.0332
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0047	0.0221	0.015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0059	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0108	0.0214
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.0086	0.0509	0.0496
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.0245	0.0873
Plasmodium vivax	hypothetical protein, conserved	0.0104	0.065	0.0793
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0068	0.0376	0.0363
Plasmodium vivax	peptide deformylase, putative	0.0951	0.6947	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.065	0.2316
Schistosoma mansoni	microtubule-associated protein tau	0.1361	1	1
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0036	0.0145	0.0328
Mycobacterium tuberculosis	Conserved protein	0.0104	0.065	0.0778
Giardia lamblia	GTOR	0.0042	0.0184	0.2812
Brugia malayi	chromobox protein homolog 3	0.0038	0.0154	0.0369
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0057	0.0294	0.0277
Trypanosoma cruzi	lanosterol synthase, putative	0.0148	0.0971	0.3503
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0221	0.0787
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.0245	0.07
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0138	0.0903	1
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0042	0.0184	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0128	0.0457
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0084	0.05	0.159
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0086	0.0509	0.0592
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0047	0.0221	0.0129
Mycobacterium tuberculosis	Probable esterase LipL	0.0104	0.065	0.0778
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.0025	0.0056	0.0049
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0036	0.0145	0.0131
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0191	0.0336
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Echinococcus granulosus	lysine specific demethylase 5A	0.0055	0.0282	0.0269
Giardia lamblia	Prenyltransferase	0.0086	0.0509	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0042	0.0184	0.017
Loa Loa (eye worm)	phosphatidylinositol 3	0.0042	0.0184	0.0654
Plasmodium falciparum	peptide deformylase	0.0951	0.6947	1
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0084	0.05	0.5243
Entamoeba histolytica	hypothetical protein	0.0032	0.0108	0.0615
Echinococcus granulosus	histone lysine methyltransferase setb	0.0073	0.0416	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0138	0.0308
Giardia lamblia	Casein kinase II beta chain	0.0084	0.05	0.9793
Schistosoma mansoni	casein kinase II beta subunit	0.0084	0.05	0.0487
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0245	0.0232
Onchocerca volvulus		0.0068	0.0376	0.0906
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0221	0.0129
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.0154	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0221	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0145	0.0515
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0021	0.0076
Brugia malayi	jmjC domain containing protein	0.0053	0.0269	0.0786
Onchocerca volvulus		0.0048	0.0229	0.0434
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0191	0.0735
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0144	0.0943	0.3662
Trichomonas vaginalis	penicillin-binding protein, putative	0.0104	0.065	0.1922
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.0302	0.0289
Echinococcus multilocularis	casein kinase ii subunit beta	0.0084	0.05	0.0487
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0042	0.0184	0.017
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0059	0.0057
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0131	0.0118
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0221	0.1947
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0042	0.0184	0.1505
Leishmania major	protein kinase ck2 regulatory subunit, putative	0.0084	0.05	0.159
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.2232
Brugia malayi	jmjC domain containing protein	0.0055	0.0282	0.0836
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Loa Loa (eye worm)	jmjC domain-containing protein	0.0055	0.0282	0.1006
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.0086	0.0509	0.1478
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Brugia malayi	beta-lactamase family protein	0.0104	0.065	0.2171
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0086	0.0509	0.166
Mycobacterium leprae	conserved hypothetical protein	0.0104	0.065	0.0638
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.005	0.0245	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0221	0.0787
Plasmodium vivax	casein kinase II beta chain, putative	0.0084	0.05	0.0573
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0304	0.2134	0.8222
Loa Loa (eye worm)	hypothetical protein	0.0041	0.018	0.064
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0104	0.065	0.0759
Trypanosoma brucei	Peptide deformylase 2	0.0363	0.2572	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0072	0.0099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0261	0.0618
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0374	0.1051
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0073	0.0416	0.0403
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0138	0.0903	0.089
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0084	0.05	0.5243
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0145	0.0148
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0041	0.0001
Brugia malayi	beta-NAC-like protein	0.0032	0.0108	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0154	0.0548
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0245	0.0946
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0059	0.0057
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.0191	0.0336
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0042	0.0184	0.017
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0138	0.0903	0.3215
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0036	0.0145	0.0336
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0104	0.065	0.0637
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0108	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0133	0.0474
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0138	0.0903	0.089
Mycobacterium tuberculosis	Conserved protein	0.0104	0.065	0.0778
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0049	0.0238	0.0189
Loa Loa (eye worm)	hypothetical protein	0.005	0.0245	0.0873
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0131	0.0118
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0221	0.0457
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0047	0.0221	0.0129
Trypanosoma brucei	lanosterol synthase	0.0148	0.0971	0.3771
Brugia malayi	Pre-SET motif family protein	0.0394	0.2807	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0145	0.0515
Onchocerca volvulus		0.0104	0.065	0.1786
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0036	0.0145	0.0053
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.005	0.0245	0.0645
Echinococcus multilocularis	chromobox protein 1	0.0067	0.0374	0.0361
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Mycobacterium tuberculosis	Conserved protein	0.0104	0.065	0.0778
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.065	0.22
Toxoplasma gondii	ck2 beta subunit	0.0084	0.05	0.0579
Trypanosoma brucei	hypothetical protein, conserved	0.0104	0.065	0.2522
Plasmodium falciparum	acyl-CoA synthetase	0.0035	0.0133	0.0036
Trichomonas vaginalis	esterase, putative	0.0104	0.065	0.1922
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0221	0.0129
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0047	0.0221	0.0129
Giardia lamblia	Rab geranylgeranyltransferase	0.0036	0.0145	0.1951
Trypanosoma brucei	Casein kinase II subunit beta, putative	0.0084	0.05	0.1937
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0035	0.0021
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0042	0.0184	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0149	0.053
Onchocerca volvulus		0.0047	0.0221	0.041
Leishmania major	lanosterol synthase, putative	0.0111	0.07	0.2401
Schistosoma mansoni	jumonji domain containing protein	0.0053	0.0269	0.0255
Loa Loa (eye worm)	Csnk2b protein	0.0084	0.05	0.1781
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.0086	0.0509	0.1974
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.005	0.0245	0.0232
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trichomonas vaginalis	D-aminoacylase, putative	0.0104	0.065	0.1922
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0073	0.0416	0.0403
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0133	0.0474
Trypanosoma cruzi	lanosterol synthase, putative	0.0148	0.0971	0.3503
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0154	0.0357
Mycobacterium ulcerans	lipase LipD	0.0104	0.065	0.0759
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0246	0.0705
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0036	0.0145	0.0059
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0047	0.0221	0.0129
Plasmodium vivax	acyl-CoA synthetase, putative	0.0035	0.0133	0.0036
Entamoeba histolytica	transcription factor BTF3, putative	0.0032	0.0108	0.0615
Echinococcus granulosus	transcription factor btf3	0.0032	0.0108	0.0095
Schistosoma mansoni	hypothetical protein	0.0034	0.0128	0.0115
Brugia malayi	Bromodomain containing protein	0.0037	0.0148	0.0349
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0033	0.012	0.0049
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0144	0.0943	0.3389
Brugia malayi	casein kinase II, putaitve	0.0025	0.0056	0.0015
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.005	0.0245	0.2232
Mycobacterium ulcerans	acyl-CoA synthetase	0.0047	0.0221	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0184	0.0451
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0555
Onchocerca volvulus	Casein kinase II subunit beta homolog	0.0084	0.05	0.1304
Toxoplasma gondii	NAC domain-containing protein	0.0032	0.0108	0.0006
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.0148	0.0971	0.1249
Treponema pallidum	polypeptide deformylase (def)	0.0951	0.6947	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0104	0.065	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0381	0.1358
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0363	0.2572	1
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.005	0.0245	0.02
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0104	0.065	0.2316
Onchocerca volvulus		0.0104	0.065	0.1786
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0145	0.0555
Mycobacterium ulcerans	hypothetical protein	0.016	0.1064	0.1366
Onchocerca volvulus		0.0449	0.3213	1
Echinococcus multilocularis	transcription factor btf3	0.0032	0.0108	0.0095
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0104	0.065	0.0778
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0035	0.0021
Mycobacterium tuberculosis	Probable lipase LipE	0.0104	0.065	0.0778
Loa Loa (eye worm)	ICD-1 protein	0.0032	0.0108	0.0386
Echinococcus multilocularis	microtubule associated protein 2	0.1361	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0104	0.065	0.1922
Loa Loa (eye worm)	beta-lactamase	0.0104	0.065	0.2316
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0191	0.0336
Trichomonas vaginalis	protein kinase ck2-beta, putative	0.0025	0.0056	0.0049
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0145	0.0148
Trypanosoma cruzi	Casein kinase II subunit beta, putative	0.0084	0.05	0.159
Echinococcus granulosus	chromobox protein 1	0.0067	0.0374	0.0361
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0042	0.0184	0.0706
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0086	0.0509	0.1628
Trichomonas vaginalis	set domain proteins, putative	0.0449	0.3213	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0053	0.0269	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0133	0.0474
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.0086	0.0509	0.0587
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0104	0.065	0.0778
Leishmania major	4-coumarate:coa ligase-like protein	0.0047	0.0221	0.0457
Trichomonas vaginalis	chromobox protein, putative	0.0067	0.0374	0.1051
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.0086	0.0509	0.0496
Mycobacterium ulcerans	esterase/lipase LipP	0.0104	0.065	0.0759
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0951	0.6947	0.5
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0221	0.0613
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0145	0.0148
Plasmodium vivax	casein kinase II beta chain, putative	0.0084	0.05	0.0573
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Mycobacterium leprae	Probable lipase LipE	0.0104	0.065	0.0638
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0075	0.0108
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0246	0.0877
Leishmania major	farnesyltransferase beta subunit	0.0086	0.0509	0.1628
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0104	0.065	0.2171
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0245	0.0555
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0073	0.0416	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.012	0.0251
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0138	0.0903	0.089
Brugia malayi	beta-lactamase family protein	0.0104	0.065	0.2171
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0951	0.6947	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0645
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.005	0.0245	0.02
Brugia malayi	AMP-binding enzyme family protein	0.0047	0.0221	0.0613
Trypanosoma cruzi	hypothetical protein, conserved	0.005	0.0245	0.0555
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0175	0.0424
Onchocerca volvulus		0.005	0.0245	0.0487
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0138	0.0903	0.2718
Mycobacterium tuberculosis	Conserved hypothetical protein	0.016	0.1064	0.1384
Mycobacterium ulcerans	hypothetical protein	0.0047	0.0221	0.0129
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Onchocerca volvulus		0.0104	0.065	0.1786
Loa Loa (eye worm)	casein kinase II	0.0025	0.0056	0.02
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0304	0.2134	0.8296
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0042	0.0184	0.0306
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0047	0.0221	0.1947
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0033	0.012	0.046
Trypanosoma cruzi	protein farnesyltransferase, putative	0.0086	0.0509	0.1628
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.012	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0104	0.065	0.2316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.012	0.0251
Mycobacterium ulcerans	beta-lactamase	0.0104	0.065	0.0759
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0072	0.0099
Schistosoma mansoni	hypothetical protein	0.002	0.0021	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0108	0.0214
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0175	0.0424
Leishmania major	hypothetical protein, conserved	0.0104	0.065	0.22
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.005	0.0245	0.0232
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0055	0.0282	0.0269
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0416	0.1484
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0042	0.0184	0.1505
Echinococcus multilocularis	tumor protein p63	0.0326	0.2302	0.2291
Trypanosoma cruzi	hypothetical protein, conserved	0.0104	0.065	0.22
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0951	0.6947	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0304	0.2134	0.8222
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.005	0.0245	0.0873
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0036	0.0145	0.0053
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0057	0.0051
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0363	0.2572	1
Schistosoma mansoni	chromobox protein	0.0067	0.0374	0.0361
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.0086	0.0509	0.1478
Trypanosoma brucei	hypothetical protein, conserved	0.005	0.0245	0.0946
Leishmania major	polypeptide deformylase-like protein, putative	0.0363	0.2572	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0042	0.0184	0.0477
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0057	0.0294	0.0281
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.002	0.002	0.007
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0104	0.065	0.0759
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0144	0.0943	0.3389
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.0086	0.0509	0.0587
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.012	0.0251
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0042	0.0184	0.0306
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Toxoplasma gondii	hypothetical protein	0.005	0.0245	0.0206
Chlamydia trachomatis	peptide deformylase	0.0951	0.6947	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0104	0.065	0.0637
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0394	0.2807	1
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0184	0.0451
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0104	0.065	0.0778
Trichomonas vaginalis	penicillin-binding protein, putative	0.0104	0.065	0.1922
Mycobacterium ulcerans	peptide deformylase	0.0951	0.6947	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0229	0.0215
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.0302	0.0289
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0246	0.0705
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0036	0.0145	0.0131
Loa Loa (eye worm)	hypothetical protein	0.0104	0.065	0.2316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.0245	0.4168
Brugia malayi	Heterochromatin protein 1	0.0067	0.0374	0.1168
Echinococcus granulosus	beta LACTamase domain containing family member	0.0104	0.065	0.0637
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0053	0.0269	0.0255
Brugia malayi	Pre-SET motif family protein	0.0057	0.0294	0.0878
Brugia malayi	Bromodomain containing protein	0.0072	0.0412	0.1307
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.005	0.0245	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.012	0.0251
Brugia malayi	hypothetical protein	0.0146	0.0959	0.3292
Giardia lamblia	Rab geranylgeranyltransferase	0.005	0.0245	0.4168
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.005	0.0245	0.07
Schistosoma mansoni	transcription factor btf3	0.0032	0.0108	0.0095
Toxoplasma gondii	hypothetical protein	0.0049	0.0238	0.0195
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0035	0.0133	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0555
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0184	0.0451
Mycobacterium tuberculosis	Probable hydrolase	0.0104	0.065	0.0778
Echinococcus granulosus	tumor protein p63	0.0326	0.2302	0.2291
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.005	0.0245	0.0232
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0128	0.0276
Brugia malayi	Csnk2b protein	0.0084	0.05	0.1626
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0229	0.0814
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0084	0.05	0.1449
Entamoeba histolytica	acyl-coA synthetase, putative	0.0047	0.0221	0.1947
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0036	0.0145	0.0328
Trypanosoma brucei	Polypeptide deformylase 1	0.0363	0.2572	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0033	0.012	0.0049
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.005	0.0245	0.02
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0041	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0104	0.065	0.2316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0057	0.0051
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.0086	0.0509	0.0496
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0946
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0363	0.2572	1
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0036	0.0145	0.0059
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0645
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0042	0.0184	0.0706
Leishmania major	geranylgeranyltransferase, putative	0.0036	0.0145	0.0148
Leishmania major	mitochondrial DNA polymerase beta	0.0304	0.2134	0.8222
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0133	0.0474
Toxoplasma gondii	ABC1 family protein	0.0104	0.065	0.0798
Brugia malayi	beta-lactamase	0.0104	0.065	0.2171
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0363	0.2572	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0667	0.4838	0.6912
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0035	0.0021
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.0086	0.0509	0.5354
Loa Loa (eye worm)	hypothetical protein	0.005	0.0246	0.0877
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.005	0.0245	0.0946
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0081	0.0129
Schistosoma mansoni	chromobox protein	0.0067	0.0374	0.0361
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0054	0.0278	0.0265
Trichomonas vaginalis	casein kinase II beta chain, putative	0.0025	0.0056	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0166	0.0591
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0086	0.0509	0.1478
Toxoplasma gondii	casein kinase ii regulatory subunit protein	0.0084	0.05	0.0579
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.0086	0.0509	0.1478
Entamoeba histolytica	casein kinase II regulatory subunit family protein	0.0084	0.05	0.5243
Mycobacterium tuberculosis	Probable lipase LipD	0.0104	0.065	0.0778
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0086	0.0509	0.1814
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.005	0.0245	0.0232
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0104	0.02
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0133	0.0474
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0104	0.065	0.0637
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0036	0.0145	0.0053
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0055	0.0282	0.0269
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.0154	0.0357
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0041	0.0001
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.005	0.0245	0.0645

Activities

Activity type	Activity value	Assay description	Source	Reference
Cytotoxic endpoint (functional)	= 25 uM	Highest nontoxic concentration for cultured NIH 3T3 cells assessed by MTT staining.	ChEMBL.	7562930
Cytotoxic endpoint (functional)	= 25 uM	Highest nontoxic concentration for cultured NIH 3T3 cells assessed by MTT staining.	ChEMBL.	7562930
IC50 (binding)	= 6.2 nM	Inhibition of bovine Geranylgeranyl transferase type I	ChEMBL.	7562930
IC50 (binding)	= 6.2 nM	Inhibition of bovine Geranylgeranyl transferase type I	ChEMBL.	7562930
IC50 (binding)	= 46 nM	In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%	ChEMBL.	7562930
IC50 (binding)	= 46 nM	In vitro concentration required to reduce Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras protein by 50%	ChEMBL.	7562930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

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Detailed information for compound 224890