Detailed information for compound 231708

Basic information

Technical information
  • TDR Targets ID: 231708
  • Name: (2Z)-1-methyl-2-[(1-propan-2-ylquinolin-1-ium -4-yl)methylidene]quinoline
  • MW: 327.442 | Formula: C23H23N2+
  • H donors: 0 H acceptors: 0 LogP: 5.63 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([n+]1ccc(c2c1cccc2)/C=c\1/ccc2c(n1C)cccc2)C
  • InChi: 1S/C23H23N2/c1-17(2)25-15-14-19(21-9-5-7-11-23(21)25)16-20-13-12-18-8-4-6-10-22(18)24(20)3/h4-17H,1-3H3/q+1
  • InChiKey: UHDVYQSRZWKNOD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-isopropyl-4-[(Z)-(1-methyl-2-quinolylidene)methyl]quinolin-1-ium
  • 4-[(Z)-(1-methylquinolin-2-ylidene)methyl]-1-propan-2-ylquinolin-1-ium
  • 4-[(Z)-(1-methylquinolin-2-ylidene)methyl]-1-propan-2-yl-quinolin-1-ium

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0111 0.0235
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0058 0.0658 0.7892
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0029 0.027 0.0794
Onchocerca volvulus 0.0011 0.0027 0.0072
Entamoeba histolytica hypothetical protein 0.0039 0.0407 0.4867
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0693 0.8321
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0057 0.0638 0.0638
Trypanosoma cruzi Heat shock protein 83, putative 0.0071 0.0833 1
Plasmodium falciparum heat shock protein 90 0.0071 0.0833 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0326
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.007 0.007
Trypanosoma brucei unspecified product 0.0015 0.0074 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0658 0.1949
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0111 0.1299
Trypanosoma brucei Heat shock protein 83, putative 0.0071 0.0833 1
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Schistosoma mansoni caspase-7 (C14 family) 0.0217 0.2791 0.2791
Echinococcus multilocularis survival motor neuron protein 1 0.0259 0.3347 0.3347
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0073 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0014 0.0073 0.0846
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Entamoeba histolytica hypothetical protein 0.0039 0.0407 0.4867
Echinococcus multilocularis caspase 2 0.0058 0.0658 0.0658
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0003 0.0003
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0058 0.0658 0.7892
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0111 0.1299
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0658 0.1949
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0074 0.0859
Echinococcus granulosus lamin 0.0029 0.0275 0.0275
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0029 0.027 0.027
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.0111
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0369 0.0797
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0358 0.4273
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0536 0.6422
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0259 0.3347 0.7282
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0638 0.1891
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0029 0.0275 0.0808
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0027 0.0072
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Echinococcus granulosus dnaJ subfamily B 0.0447 0.5878 0.5878
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0027 0.0027
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0003 0.0003
Brugia malayi Hsp90 protein 0.0029 0.027 0.0581
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0073 0.0846
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0027 0.0053
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0014 0.0073 0.1105
Trichomonas vaginalis sensor histidine kinase, putative 0.0014 0.0073 0.0209
Schistosoma mansoni DNA topoisomerase II 0.0014 0.0073 0.0073
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0073 0.0209
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.0039 0.0407 0.0879
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0049 0.0536 0.116
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0003 0.0003
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0091 0.0191
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Treponema pallidum heat shock protein 90 0.0057 0.0638 1
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.0833 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Plasmodium falciparum endoplasmin, putative 0.0044 0.0464 0.5556
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0153
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0658 0.7892
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0014 0.0073 0.1105
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0014 0.0073 0.1105
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0027 0.0053
Echinococcus granulosus hypothetical protein 0.003 0.0278 0.0278
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.5878 0.5878
Brugia malayi nuclear receptor NHR-88 0.0011 0.0027 0.0053
Echinococcus granulosus tumor protein p63 0.037 0.4835 0.4835
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Brugia malayi isocitrate dehydrogenase 0.0017 0.0111 0.0235
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0003 0.0003
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0028 0.0301
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0014 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.013
Schistosoma mansoni hypothetical protein 0.0039 0.0407 0.0407
Echinococcus granulosus caspase 3 0.0159 0.2012 0.2012
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0658 0.1949
Echinococcus multilocularis caspase 0.0217 0.2791 0.2791
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Trypanosoma brucei metacaspase MCA3 0.0058 0.0658 0.7892
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0111 0.1299
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0153
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0073 0.0846
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0073 0.0846
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0605 0.0605
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0003 0.0003
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0162 0.0474
Leishmania major DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Loa Loa (eye worm) hypothetical protein 0.0096 0.1172 0.2544
Trypanosoma brucei heat shock protein 90, putative 0.0071 0.0833 1
Brugia malayi Pre-SET motif family protein 0.0228 0.2941 0.6396
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0027 0.0053
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0326 0.3895
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0003 0.0003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0326 0.0326
Schistosoma mansoni DNA polymerase eta 0.0049 0.0536 0.0536
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0014 0.0073 0.1105
Echinococcus multilocularis caspase 8 0.0058 0.0658 0.0658
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0027 0.0053
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0073 0.0073
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0638 0.1891
Loa Loa (eye worm) hypothetical protein 0.0029 0.0268 0.0576
Schistosoma mansoni cpg binding protein 0.0033 0.0324 0.0324
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0028 0.0301
Mycobacterium ulcerans DNA gyrase subunit B 0.0014 0.0073 0.1105
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0026 0.0026
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0027 0.0027
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0014 0.0073 0.0153
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Echinococcus granulosus dna polymerase kappa 0.0021 0.0162 0.0162
Schistosoma mansoni ATPase 0.0009 0.0003 0.0003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.0111
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0014 0.0073 0.1105
Echinococcus granulosus survival motor neuron protein 1 0.0259 0.3347 0.3347
Brugia malayi intermediate filament protein 0.0029 0.0275 0.0591
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0014 0.0073 0.1105
Schistosoma mansoni hypothetical protein 0.003 0.0278 0.0278
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0369 0.0797
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0014 0.0073 0.1105
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0027 0.0027
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0028 0.0301
Loa Loa (eye worm) heat shock protein 90 0.0071 0.0833 0.1806
Schistosoma mansoni microtubule-associated protein tau 0.0755 1 1
Toxoplasma gondii heat shock protein HSP90 0.0071 0.0833 1
Brugia malayi Probable DNA topoisomerase II 0.0014 0.0073 0.0153
Toxoplasma gondii heat shock protein 75, putative 0.0029 0.027 0.3215
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0162 0.2504
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0073 0.0209
Giardia lamblia DINP protein human, muc B family 0.0021 0.0162 0.1918
Plasmodium falciparum DNA gyrase subunit B 0.0014 0.0073 0.0846
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0014 0.0073 0.0209
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Brugia malayi Cell death protein 3 precursor 0.0058 0.0658 0.1425
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0027 0.0053
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0259 0.3347 0.7282
Brugia malayi Endoplasmin precursor 0.0071 0.0833 0.1806
Schistosoma mansoni lamin 0.0029 0.0275 0.0275
Plasmodium falciparum metacaspase-like protein 0.0058 0.0658 0.7892
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0217 0.2791 0.2791
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0162 0.2504
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0073 1
Trypanosoma brucei DNA topoisomerase ii 0.0014 0.0073 0.0846
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0014 0.0073 0.1105
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0162 0.1918
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0073 0.0846
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0073 0.0846
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0326 0.0326
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0003 0.0003
Brugia malayi hypothetical protein 0.003 0.0278 0.0599
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0003 0.0003
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0003 0.0003
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0014 0.0073 0.0741
Plasmodium vivax endoplasmin, putative 0.0071 0.0833 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0014 0.0073 0.0209
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0014 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Schistosoma mansoni hypothetical protein 0.003 0.0278 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0027 0.0053
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0014 0.0073 0.0209
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0833 1
Trichomonas vaginalis heat shock protein, putative 0.0071 0.0833 0.2469
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0073 0.0846
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0058 0.0658 0.1425
Plasmodium falciparum metacaspase 1 0.0058 0.0658 0.7892
Trypanosoma cruzi metacaspase, putative 0.0058 0.0658 0.7892
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0111 0.0111
Plasmodium vivax DNA gyrase subunit B, putative 0.0014 0.0073 0.0846
Trichomonas vaginalis heat shock protein, putative 0.0029 0.027 0.0794
Toxoplasma gondii DNA topoisomerase 2, putative 0.0014 0.0073 0.0846
Giardia lamblia Grp94/Hsp90 0.0057 0.0638 0.7659
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0028 0.0301
Echinococcus multilocularis caspase 3 0.0159 0.2012 0.2012
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0658 0.1949
Schistosoma mansoni heat shock protein 0.0029 0.027 0.027
Mycobacterium tuberculosis Conserved protein 0.0014 0.0073 0.1105
Echinococcus granulosus heat shock protein 0.0071 0.0833 0.0833
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0358 0.4273
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0014 0.0073 0.0073
Echinococcus multilocularis heat shock protein 90 0.0071 0.0833 0.0833
Brugia malayi ecdysteroid receptor 0.0011 0.0027 0.0053
Echinococcus multilocularis microtubule associated protein 2 0.0755 1 1
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0014 0.0073 0.1105
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0003 0.0003
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0111 0.1696
Loa Loa (eye worm) hypothetical protein 0.0096 0.1172 0.2544
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Brugia malayi Temporarily assigned gene name protein 44 0.003 0.0278 0.0599
Brugia malayi tumor suppressor. 0.0352 0.4596 1
Leishmania major DNA polymerase eta, putative 0.0034 0.0341 0.4069
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.0029 0.0275 0.0591
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.003 0.0278 0.0599
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0058 0.0658 0.0658
Schistosoma mansoni coup transcription factor 0.0011 0.0027 0.0027
Toxoplasma gondii Hsp90 domain-containing protein 0.0029 0.027 0.3215
Schistosoma mansoni cpg binding protein 0.0031 0.03 0.03
Schistosoma mansoni heat shock protein 0.0071 0.0833 0.0833
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0111 0.0235
Schistosoma mansoni survival motor neuron protein 0.0053 0.0587 0.0587
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0833 1
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0003 0.0003
Schistosoma mansoni rotamase 0.0037 0.0369 0.0369
Onchocerca volvulus Cell death protein 3 homolog 0.0058 0.0658 0.1949
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0027 0.0027
Mycobacterium tuberculosis Possible two component sensor kinase 0.0014 0.0073 0.1105
Trypanosoma brucei heat shock protein 84, putative 0.0029 0.027 0.3215
Trichomonas vaginalis endoplasmin, putative 0.0044 0.0464 0.1372
Loa Loa (eye worm) hypothetical protein 0.0014 0.0063 0.013
Mycobacterium ulcerans heat shock protein 90 0.0057 0.0638 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0073 0.0846
Trypanosoma cruzi metacaspase, putative 0.0058 0.0658 0.7892
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0162 0.0346
Echinococcus multilocularis expressed protein 0.0037 0.0369 0.0369
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0028 0.0301
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.03 0.0647
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0162 0.1918
Leishmania major heat shock protein, putative 0.0029 0.027 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0658 0.1949
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0407 0.0407
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.2941 0.6396
Loa Loa (eye worm) tumor suppressor 0.0352 0.4596 1
Echinococcus granulosus caspase 2 0.0058 0.0658 0.0658
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0027 0.0027
Schistosoma mansoni heat shock protein 0.0071 0.0833 0.0833
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0027 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0074 0.0859
Plasmodium vivax heat shock protein 90, putative 0.0029 0.027 0.3215
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0162 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Echinococcus multilocularis lamin dm0 0.0029 0.0275 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0027 0.0053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0789 0.0789
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0111 0.1299
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0014 0.0073 0.0846
Schistosoma mansoni pyruvate dehydrogenase 0.0014 0.0073 0.0073
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.027 0.3215
Plasmodium vivax metacaspase 1, putative 0.0058 0.0658 0.7892
Trypanosoma cruzi heat shock protein 90, putative 0.0071 0.0833 1
Trypanosoma brucei metacaspase 5, putative 0.0058 0.0658 0.7892
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Schistosoma mansoni endoplasmin 0.0071 0.0833 0.0833
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.0833 1
Schistosoma mansoni caspase-7 (C14 family) 0.0058 0.0658 0.0658
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0014 0.0073 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0027 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Giardia lamblia Pms1-like protein 0.0014 0.0073 0.0846
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0027 0.0053
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0014 0.0073 0.1105
Onchocerca volvulus 0.0029 0.0275 0.0808
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0027 0.0072
Trichomonas vaginalis rotamase, putative 0.0036 0.0358 0.1055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0027 0.0027
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0536 0.116
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0027 0.0027
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0014 0.0073 0.1105
Echinococcus granulosus cpg binding protein 0.0033 0.0324 0.0324
Echinococcus multilocularis musashi 0.0029 0.0275 0.0275
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0014 0.0073 0.0073
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0162 0.2504
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0111 0.1299
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0014 0.0073 0.0153
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0003 0.0003
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0111 0.0111
Echinococcus multilocularis lamin 0.0029 0.0275 0.0275
Plasmodium vivax SET domain protein, putative 0.0033 0.0326 0.3895
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0014 0.0073 0.0073
Leishmania major DNA topoisomerase ii 0.0014 0.0073 0.0846
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0073 0.0209
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0162 0.1918
Leishmania major mitochondrial DNA topoisomerase II 0.0014 0.0073 0.0846
Trichomonas vaginalis rotamase, putative 0.0037 0.0369 0.1089
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0014 0.0073 0.1105
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0341 0.4069
Echinococcus multilocularis dna polymerase eta 0.0049 0.0536 0.0536
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0536 0.6422
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0027 0.0027
Schistosoma mansoni eyes absent homolog 0.0096 0.1172 0.1172
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0162 0.0346
Onchocerca volvulus 0.0053 0.0587 0.1737
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0027 0.0053
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0442 0.529
Leishmania major hypothetical protein, conserved 0.0014 0.0073 0.0846
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0027 0.0027
Trypanosoma cruzi metacaspase, putative 0.0058 0.0658 0.7892
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.007 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0058 0.0658 0.1425
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0073 0.0209
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0014 0.0073 0.1105
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0014 0.0073 0.0846
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0091 0.0191
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0073 0.0209
Schistosoma mansoni hypothetical protein 0.0053 0.0587 0.0587
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0027 0.0027
Schistosoma mansoni ATPase 0.0009 0.0003 0.0003
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0027 0.0027
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0029 0.027 0.3215
Plasmodium vivax DNA topoisomerase II, putative 0.0014 0.0073 0.0846
Trichomonas vaginalis DNA topoisomerase II, putative 0.0014 0.0073 0.0209
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0111 0.1299
Onchocerca volvulus 0.026 0.3362 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0014 0.0073 0.1105
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0057 0.0638 1
Mycobacterium ulcerans two component sensor kinase MprB 0.0014 0.0073 0.1105
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0024 0.0045
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0073 0.0209
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0111 0.1299
Trypanosoma cruzi heat shock protein 85, putative 0.0071 0.0833 1
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0014 0.0073 0.0209
Mycobacterium leprae Probable two component sensor kinase MprB 0.0014 0.0073 0.1105
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.0111
Plasmodium falciparum heat shock protein 90, putative 0.0029 0.027 0.3215
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0073 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0587 0.127
Echinococcus granulosus expressed protein 0.0037 0.0369 0.0369
Echinococcus granulosus heat shock protein 90 0.0057 0.0638 0.0638
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0027 0.0027
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0658 0.1949
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0326
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0003 0.0003
Echinococcus granulosus caspase 0.0217 0.2791 0.2791
Plasmodium vivax heat shock protein, putative 0.0029 0.027 0.3215
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0027 0.0027
Trypanosoma cruzi heat shock protein 85, putative 0.0057 0.0638 0.7659
Brugia malayi nuclear hormone receptor 0.0011 0.0027 0.0053
Toxoplasma gondii heat shock protein 90, putative 0.0071 0.0833 1
Brugia malayi hypothetical protein 0.0096 0.1172 0.2544
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0162 0.1918
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0275 0.0591
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0027 0.0053
Leishmania major DNA polymerase eta, putative 0.0049 0.0536 0.6422
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0275 0.0591
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0027 0.0053
Trichomonas vaginalis heat shock protein, putative 0.0057 0.0638 0.1891
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Onchocerca volvulus 0.0031 0.03 0.0885
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0014 0.0073 0.1105
Entamoeba histolytica DNA topoisomerase II, putative 0.0014 0.0073 0.0846
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0027 0.0027
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Onchocerca volvulus 0.0054 0.0605 0.179
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0162 0.0162
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0057 0.0638 0.7659
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0003 0.0003
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0111 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0027 0.0053
Giardia lamblia Heat shock protein HSP 90-alpha 0.0071 0.0833 1
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Entamoeba histolytica hypothetical protein 0.0039 0.0407 0.4867
Mycobacterium ulcerans putative regultory protein 0.0014 0.0073 0.1105
Echinococcus multilocularis tumor protein p63 0.037 0.4835 0.4835
Loa Loa (eye worm) hypothetical protein 0.0014 0.0073 0.0153
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0014 0.0073 0.1105
Trypanosoma cruzi metacaspase 5, putative 0.0058 0.0658 0.7892
Trypanosoma cruzi heat shock protein, putative 0.0029 0.027 0.3215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0326 0.0326
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0358 0.4273
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0162 0.1918
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0027 0.0053
Loa Loa (eye worm) endoplasmin 0.0071 0.0833 0.1806
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0464 0.1372
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0027 0.0053
Echinococcus multilocularis endoplasmin 0.0057 0.0638 0.0638
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0003 0.0003
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0027 0.0072
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0057 0.0638 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0058 0.0658 0.1425
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0358 0.4273
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Schistosoma mansoni endoplasmin 0.0071 0.0833 0.0833
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0014 0.0073 0.1105
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Schistosoma mansoni hypothetical protein 0.0447 0.5878 0.5878
Brugia malayi Pre-SET motif family protein 0.0033 0.0326 0.0703
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0162 0.0162
Trypanosoma brucei heat shock protein, putative 0.0071 0.0833 1
Plasmodium vivax heat shock protein 86, putative 0.0071 0.0833 1
Leishmania major heat shock protein 83-1 0.0071 0.0833 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0162 0.2504
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0162 0.0162
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0111 0.1299
Loa Loa (eye worm) heat shock protein 75 0.0029 0.027 0.0581
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0074 0.0859
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.0073 0.0153
Echinococcus granulosus protein quaking 0.003 0.0278 0.0278
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0058 0.0658 0.7892
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0073 0.0073
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0003 0.0003
Trypanosoma brucei metacaspase 0.0058 0.0658 0.7892
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0027 0.0053
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0027 0.0053
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0014 0.0073 0.1105
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0027 0.0027
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0073 0.0846
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0027 0.0053
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0014 0.0073 0.1105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0027 0.0053
Echinococcus multilocularis cpg binding protein 0.0033 0.0324 0.0324
Trypanosoma brucei Metacaspase-4 0.0058 0.0658 0.7892
Echinococcus granulosus heat shock protein 90 0.0071 0.0833 0.0833
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0027 0.0053
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0014 0.0073 0.0846
Trichomonas vaginalis set domain proteins, putative 0.026 0.3362 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0054 0.0605 0.1309
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0003 0.0003
Schistosoma mansoni cpg binding protein 0.0033 0.0324 0.0324
Trypanosoma cruzi heat shock protein 90, putative 0.0057 0.0638 0.7659
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0275 0.0591
Echinococcus granulosus lamin dm0 0.0029 0.0275 0.0275
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0003 0.0003
Echinococcus multilocularis heat shock protein 90 0.0057 0.0638 0.0638
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0162 0.1918
Leishmania major metacaspase, putative 0.0058 0.0658 0.7892
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0301 0.0301
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0073 0.0846
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0014 0.0073 0.0741
Trypanosoma cruzi metacaspase 5, putative 0.0058 0.0658 0.7892
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0341 0.4069
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0057 0.0638 1
Echinococcus multilocularis protein quaking 0.003 0.0278 0.0278
Echinococcus granulosus dna polymerase eta 0.0049 0.0536 0.0536
Brugia malayi heat shock protein 90 0.0071 0.0833 0.1806
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Giardia lamblia Heat shock protein HSP 90-alpha 0.0057 0.0638 0.7659
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0111 0.1299
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0162 0.0474
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0027 0.0027
Leishmania major developmentally regulated phosphoprotein-like protein 0.0014 0.0073 0.0846
Trypanosoma cruzi metacaspase, putative 0.0058 0.0658 0.7892
Entamoeba histolytica heat shock protein 90, putative 0.0071 0.0833 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0058 0.0658 0.1949
Trypanosoma brucei unspecified product 0.0021 0.0162 0.1918
Loa Loa (eye worm) hypothetical protein 0.0033 0.0326 0.0703
Trypanosoma brucei unspecified product 0.0015 0.0074 0.0859
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0014 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0027 0.0053
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0358 0.4273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0407 0.0407
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0027 0.0027
Schistosoma mansoni caspase-3 (C14 family) 0.0217 0.2791 0.2791
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0014 0.0073 0.0846
Trypanosoma brucei metacaspase MCA2 0.0058 0.0658 0.7892
Mycobacterium ulcerans two component regulator - sensor kinase 0.0014 0.0073 0.1105
Brugia malayi CXXC zinc finger family protein 0.0031 0.03 0.0647
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0029 0.027 0.027
Schistosoma mansoni lamin 0.0029 0.0275 0.0275
Schistosoma mansoni intermediate filament proteins 0.0029 0.0275 0.0275
Brugia malayi steroid hormone receptor 0.0011 0.0027 0.0053
Echinococcus multilocularis heat shock protein 0.0071 0.0833 0.0833
Echinococcus granulosus endoplasmin 0.0057 0.0638 0.0638
Echinococcus granulosus intermediate filament protein 0.0029 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0026 0.0049
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0027 0.0053
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0073 0.0846
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0407 0.0407
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0003 0.0003
Mycobacterium leprae Probable two-component sensor kinase 0.0014 0.0073 0.1105
Brugia malayi kinase, mitochondrial precursor 0.0014 0.0073 0.0153
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0014 0.0073 0.1105
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0003 0.0003
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0217 0.2791 0.2791
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0014 0.007 0.0146
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0358 0.4273
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0369 0.1089
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0014 0.0073 0.1105
Plasmodium falciparum DNA topoisomerase 2 0.0014 0.0073 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0027 0.0053
Onchocerca volvulus 0.0033 0.0326 0.0962
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0053
Echinococcus granulosus caspase 8 0.0058 0.0658 0.0658
Entamoeba histolytica hypothetical protein 0.0039 0.0407 0.4867

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 51 nM l-1 Tested for the inhibition of extraneuronal [3H]-norepinephrine uptake in Caki-1 cells ChEMBL. 8277503
IC50 (functional) = 51 nM l-1 Tested for the inhibition of extraneuronal [3H]-norepinephrine uptake in Caki-1 cells ChEMBL. 8277503
logP (ADMET) = 0.92 Partition coefficient (logP) ChEMBL. 8277503

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8277503

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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