Detailed information for compound 24974

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 318.411 | Formula: C18H26N2O3
  • H donors: 1 H acceptors: 1 LogP: 2.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1CCCCC1N1CCN(CC1)Cc1ccc2c(c1)OCO2
  • InChi: 1S/C18H26N2O3/c21-16-4-2-1-3-15(16)20-9-7-19(8-10-20)12-14-5-6-17-18(11-14)23-13-22-17/h5-6,11,15-16,21H,1-4,7-10,12-13H2
  • InChiKey: PTDHBHVYNLQEDV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 18 (vesicular acetylcholine transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma mansoni vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Brugia malayi vesicular acetylcholine transporter unc-17 Get druggable targets OG5_133283 All targets in OG5_133283
Onchocerca volvulus Vesicular acetylcholine transporter homolog Get druggable targets OG5_133283 All targets in OG5_133283
Schistosoma japonicum ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative Get druggable targets OG5_133283 All targets in OG5_133283
Echinococcus granulosus vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
Echinococcus multilocularis vesicular acetylcholine transporter Get druggable targets OG5_133283 All targets in OG5_133283
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Abnormal catecholamine distribution protein 1 solute carrier family 18 (vesicular acetylcholine transporter), member 3 532 aa 504 aa 34.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0141 0.1943 1
Echinococcus multilocularis somatostatin receptor 0.0029 0.0291 0.046
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0291 0.046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0291 0.046
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0124 0.0172
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.0291 0.046
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0093 0.0144
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 0.8035
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0093 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Onchocerca volvulus 0.0029 0.0291 0.0687
Schistosoma mansoni hydrolase 0.0019 0.014 0.0181
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0019 0.014 0.0048
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0019 0.014 0.0259
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0093 0.0144
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0019 0.014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0027 0.004
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0019 0.014 0.0259
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.0291 0.076
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0365
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0141 0.1943 1
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0019 0.014 0.0289
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0221 0.031
Onchocerca volvulus 0.0029 0.0291 0.0687
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0141 0.1943 1
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1721 0.2705
Echinococcus multilocularis orexin receptor type 2 0.0029 0.0291 0.046
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0434 0.1702
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0019 0.014 0.0221
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Entamoeba histolytica hypothetical protein 0.0141 0.1943 1
Plasmodium falciparum epoxide hydrolase 1 0.0019 0.014 0.0208
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0221 0.0349
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Echinococcus multilocularis geminin 0.035 0.5026 0.7989
Brugia malayi Endoplasmin precursor 0.0045 0.0531 0.1395
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0221 0.0581
Echinococcus granulosus nuclear receptor nhr 48 0.0011 0.0031 0.0047
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0141 0.1943 0.5108
Schistosoma mansoni biogenic amine receptor 0.0029 0.0291 0.0421
Loa Loa (eye worm) endoplasmin 0.0045 0.0531 0.1391
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0221 0.031
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0019 0.014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Mycobacterium ulcerans hypothetical protein 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0434 0.1702
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Trypanosoma cruzi Heat shock protein 83, putative 0.0045 0.0531 0.2367
Mycobacterium ulcerans peroxidase BpoB 0.0019 0.014 0.0016
Echinococcus granulosus sex peptide receptor 0.0029 0.0291 0.046
Toxoplasma gondii Hsp90 domain-containing protein 0.0172 0.2396 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Mycobacterium ulcerans hypothetical protein 0.0019 0.014 0.0016
Echinococcus multilocularis heat shock protein 0.0045 0.0531 0.0841
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0031 0.0047
Brugia malayi nuclear hormone receptor 0.0011 0.0031 0.0083
Brugia malayi hydrolase, alpha/beta fold family protein 0.0019 0.014 0.0369
Echinococcus multilocularis nuclear receptor nhr 48 0.0011 0.0031 0.0047
Trypanosoma cruzi hydrolase-like protein 0.0019 0.014 0.0259
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0221 0.0349
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0291 0.046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.014 0.0088
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0291 0.046
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Mycobacterium ulcerans hypothetical protein 0.0019 0.014 0.0016
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0018 0.0124 0.0195
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0221 0.0577
Echinococcus granulosus neuropeptide receptor 0.0029 0.0291 0.046
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0018 0.0124 0.0195
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0221 0.0349
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0221 0.0581
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.023 0.0742
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0018 0.0124 0.0323
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.0291 0.046
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0291 0.0421
Plasmodium vivax alpha/beta hydrolase, putative 0.0019 0.014 0.0208
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0018 0.0124 0.0327
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.0205 0.0081
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0027 0.004
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0019 0.014 0.0369
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Schistosoma mansoni adenoreceptor 0.0029 0.0291 0.0421
Trichomonas vaginalis hydrolase, putative 0.0019 0.014 0.0088
Mycobacterium leprae Probable exported protease 0.0019 0.014 0.0438
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0531 0.2233
Loa Loa (eye worm) heat shock protein 75 0.003 0.0306 0.0801
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0052 0.0136
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Mycobacterium ulcerans epoxide hydrolase EphF 0.0019 0.014 0.0016
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0387 0.0613
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.0291 0.0764
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0018 0.0124 0.0156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0221 0.0577
Mycobacterium ulcerans exported protease 0.0019 0.014 0.0016
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.0291 0.0421
Schistosoma mansoni opsin-like receptor 0.0029 0.0291 0.0421
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0221 0.0349
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.0291 0.076
Brugia malayi MH2 domain containing protein 0.0118 0.1604 0.4216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.0291 0.0764
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0306 0.0484
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0291 0.046
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0291 0.076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Schistosoma mansoni neuropeptide receptor 0.0029 0.0291 0.0421
Trypanosoma cruzi hydrolase-like protein, putative 0.0019 0.014 0.0259
Schistosoma mansoni hypothetical protein 0.0036 0.0387 0.0575
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0011 0.0031 0.0047
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0141 0.1943 1
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.0291 0.076
Brugia malayi Nuclear hormone receptor-like 1 0.0013 0.0052 0.0136
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.0291 0.0421
Brugia malayi ecdysone receptor 0.0011 0.0031 0.0083
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0019 0.014 0.0048
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.0291 0.046
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0291 0.0421
Mycobacterium ulcerans epoxide hydrolase EphB 0.0019 0.014 0.0016
Brugia malayi nuclear receptor NHR-88 0.0024 0.0221 0.0581
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0306 0.0484
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0018 0.0124 0.0327
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.0291 0.046
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.0291 0.046
Brugia malayi follicle stimulating hormone receptor 0.0029 0.0291 0.0764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0221 0.0577
Trichomonas vaginalis heat shock protein, putative 0.0042 0.049 0.2007
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0019 0.014 0.0088
Schistosoma mansoni cpg binding protein 0.0032 0.0339 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0221 0.0581
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0291 0.046
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0221 0.031
Echinococcus multilocularis serotonin receptor 0.0029 0.0291 0.046
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0019 0.014 0.0208
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Brugia malayi heat shock protein 90 0.0045 0.0531 0.1395
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0291 0.046
Mycobacterium ulcerans exported protease 0.0019 0.014 0.0016
Brugia malayi Serotonin receptor 0.0029 0.0291 0.0764
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0221 0.0581
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0291 0.0421
Mycobacterium tuberculosis Probable hydrolase 0.0018 0.0124 0.0032
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.0291 0.046
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0141 0.1943 0.3059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Echinococcus granulosus allatostatin A receptor 0.0029 0.0291 0.046
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.023 0.0742
Schistosoma mansoni neuropeptide receptor 0.0029 0.0291 0.0421
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0018 0.0124 0.0323
Brugia malayi hypothetical protein 0.0013 0.0052 0.0136
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.0291 0.046
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Schistosoma mansoni amine GPCR 0.0029 0.0291 0.0421
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.629 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.014 0.0088
Onchocerca volvulus 0.0029 0.0291 0.0687
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0023 0.0205 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0031 0.0047
Echinococcus multilocularis abhydrolase domain containing protein 0.0019 0.014 0.0221
Schistosoma mansoni zinc finger protein 0.0011 0.0031 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0019 0.014 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0221 0.0349
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.0291 0.046
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0221 0.0577
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0141 0.1943 1
Schistosoma mansoni nuclear receptor 0.0011 0.0031 0.0007
Leishmania major hydrolase-like protein 0.0019 0.014 0.0259
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0387 0.0575
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1444
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Brugia malayi TAR-binding protein 0.0126 0.1721 0.4524
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0221 0.0349
Echinococcus multilocularis vesicular acetylcholine transporter 0.0267 0.3804 0.6047
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0018 0.0124 0.0138
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.0291 0.046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0031 0.0047
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0018 0.0124 0.0323
Mycobacterium tuberculosis Probable oxidoreductase 0.0019 0.014 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0221 0.031
Schistosoma mansoni hypothetical protein 0.0029 0.0291 0.0421
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.014 0.0088
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.0291 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0011 0.0031 0.0047
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0531 0.2367
Mycobacterium ulcerans epoxide hydrolase EphE 0.0019 0.014 0.0016
Trichomonas vaginalis endoplasmin, putative 0.0033 0.0347 0.1225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0221 0.0577
Schistosoma mansoni coup transcription factor 0.0024 0.0221 0.031
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0031 0.0083
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0019 0.014 0.0048
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1444
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus neuropeptide s receptor 0.0029 0.0291 0.046
Brugia malayi putative neuropeptide receptor 0.0029 0.0291 0.0764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0221 0.0577
Leishmania major hydrolase-like protein,esterase-like protein 0.0019 0.014 0.0259
Giardia lamblia Grp94/Hsp90 0.0042 0.049 0.2007
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0347 0.1225
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.0291 0.046
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0019 0.014 0.0259
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0019 0.014 0.0438
Echinococcus granulosus fmrfamide receptor 0.0029 0.0291 0.046
Plasmodium falciparum polyprenol reductase, putative 0.0141 0.1943 0.8035
Plasmodium falciparum heat shock protein 90 0.0045 0.0531 0.1902
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.023 0.0742
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0221 0.0502
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi nuclear receptor NHR-67 0.0011 0.0031 0.0083
Onchocerca volvulus Lipase homolog 0.0019 0.014 0.0289
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0291 0.046
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0019 0.014 0.0048
Plasmodium falciparum endoplasmin, putative 0.0033 0.0347 0.1106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0221 0.0349
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi tailless protein 0.0011 0.0031 0.0083
Brugia malayi G protein-coupled receptor 0.0029 0.0291 0.0764
Echinococcus granulosus g-protein coupled receptor 0.0029 0.0291 0.046
Brugia malayi Nuclear hormone receptor E75 0.0011 0.0031 0.0083
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Onchocerca volvulus 0.0029 0.0291 0.0687
Brugia malayi Hsp90 protein 0.003 0.0306 0.0805
Plasmodium vivax polyprenol reductase, putative 0.0141 0.1943 0.8035
Plasmodium vivax hypothetical protein, conserved 0.0019 0.014 0.0208
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0291 0.046
Mycobacterium ulcerans acyl-CoA synthetase 0.0019 0.014 0.0016
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0141 0.1943 0.8035
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0434 0.1845
Brugia malayi neuropeptide F receptor 0.0029 0.0291 0.0764
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0011 0.0031 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1943 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.0291 0.0764
Onchocerca volvulus 0.0029 0.0291 0.0687
Schistosoma mansoni endoplasmin 0.0045 0.0531 0.0804
Loa Loa (eye worm) nuclear hormone receptor 0.0011 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.1721 0.4521
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0013 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0131
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.0291 0.0687
Mycobacterium ulcerans haloalkane dehalogenase 0.0019 0.014 0.0016
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0018 0.0124 0.0327
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0093 0.0244
Onchocerca volvulus 0.0029 0.0291 0.0687
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0221 0.0577
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Plasmodium vivax heat shock protein, putative 0.0172 0.2396 1
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0291 0.046
Echinococcus granulosus endoplasmin 0.0042 0.049 0.0776
Brugia malayi AKH receptor 0.0029 0.0291 0.0764
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.0291 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0221 0.0349
Loa Loa (eye worm) TAR-binding protein 0.0126 0.1721 0.4521
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0141 0.1943 0.8035
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0019 0.014 0.0259
Brugia malayi nuclear receptor NHR-88 0.0011 0.0031 0.0083
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0018 0.0124 0.0032
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0221 0.031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.0291 0.0764
Plasmodium vivax heat shock protein 86, putative 0.0045 0.0531 0.1902
Giardia lamblia ENC6 protein 0.0019 0.014 0.0088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.023 0.0596
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0221 0.031
Echinococcus granulosus g protein coupled receptor 0.0029 0.0291 0.046
Echinococcus granulosus geminin 0.035 0.5026 0.7989
Mycobacterium leprae Probable exported protease 0.0019 0.014 0.0438
Echinococcus granulosus abhydrolase domain containing protein 11 0.0019 0.014 0.0221
Schistosoma mansoni neuropeptide receptor 0.0029 0.0291 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0313 0.082
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1721 0.2705
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Loa Loa (eye worm) hypothetical protein 0.0025 0.023 0.06
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0291 0.046
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.014 0.0088
Echinococcus granulosus heat shock protein 90 0.0039 0.0434 0.0687
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0306 0.0728
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.0291 0.0764
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0019 0.014 0.0221
Onchocerca volvulus Lipase homolog 0.0019 0.014 0.0289
Schistosoma mansoni cpg binding protein 0.0032 0.0339 0.0498
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0031 0.0007
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0018 0.0124 0.0323
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.014 0.0088
Brugia malayi hypothetical protein 0.0011 0.0031 0.0083
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0291 0.046
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0019 0.014 0.0016
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0141 0.1943 0.3059
Trypanosoma cruzi hydrolase-like protein, putative 0.0019 0.014 0.0259
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Trichomonas vaginalis heat shock protein, putative 0.0042 0.049 0.2007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0221 0.0349
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Brugia malayi CXXC zinc finger family protein 0.0031 0.0313 0.0824
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.0291 0.046
Leishmania major hypothetical protein, conserved 0.0025 0.023 0.0742
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.0291 0.076
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0031 0.0007
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Onchocerca volvulus 0.0029 0.0291 0.0687
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0141 0.1943 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.1943 0.5105
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0018 0.0124 0.0327
Mycobacterium ulcerans hypothetical protein 0.0019 0.014 0.0016
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Echinococcus granulosus serotonin receptor 0.0029 0.0291 0.046
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.0291 0.046
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0019 0.014 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1721 0.2705
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0291 0.046
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.0291 0.046
Echinococcus granulosus dnaJ subfamily B 0.0435 0.629 1
Schistosoma mansoni amine GPCR 0.0029 0.0291 0.0421
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0093 0.0144
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.0291 0.046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus somatostatin receptor 0.0029 0.0291 0.046
Onchocerca volvulus 0.0141 0.1943 0.5067
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0011 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0221 0.0502
Onchocerca volvulus 0.0029 0.0291 0.0687
Schistosoma mansoni myosin xvIII 0.0029 0.0291 0.0421
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0531 0.2233
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.014 0.0259
Schistosoma mansoni hypothetical protein 0.0029 0.0291 0.0421
Onchocerca volvulus 0.0029 0.0291 0.0687
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.0291 0.076
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.0291 0.0687
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.0291 0.046
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.0291 0.046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0018 0.0124 0.0323
Brugia malayi hypothetical protein 0.0036 0.0387 0.1017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Schistosoma mansoni biogenic amine receptor 0.0029 0.0291 0.0421
Brugia malayi ecdysteroid receptor 0.0024 0.0221 0.0581
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0124 0.0032
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Echinococcus granulosus cpg binding protein 0.0032 0.0339 0.0537
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.0291 0.046
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0221 0.0581
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0031 0.0047
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Loa Loa (eye worm) hypothetical protein 0.0141 0.1943 0.5105
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Leishmania major hypothetical protein, conserved 0.0019 0.014 0.0259
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0141 0.1943 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0291 0.0421
Echinococcus granulosus vesicular acetylcholine transporter 0.0267 0.3804 0.6047
Onchocerca volvulus 0.0024 0.0221 0.0502
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0221 0.0349
Schistosoma mansoni hypothetical protein 0.035 0.5026 0.7981
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.0291 0.0421
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.0291 0.046
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.0291 0.046
Mycobacterium ulcerans hydrolase 0.0019 0.014 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0221 0.0349
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0141 0.1943 1
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.0291 0.046
Brugia malayi Dopamine receptor protein 2 0.0029 0.0291 0.0764
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi Melatonin receptor type 1A 0.0029 0.0291 0.0764
Brugia malayi vesicular acetylcholine transporter unc-17 0.0267 0.3804 1
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0221 0.0581
Echinococcus granulosus g protein coupled receptor 0.0029 0.0291 0.046
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0011 0.0031 0.0007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0019 0.014 0.0088
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0221 0.031
Trypanosoma brucei heat shock protein, putative 0.0045 0.0531 0.2367
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0221 0.031
Schistosoma mansoni opsin-like receptor 0.0029 0.0291 0.0421
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Toxoplasma gondii alpha/beta hydrolase, putative 0.0019 0.014 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.023 0.0596
Echinococcus multilocularis allatostatin A receptor 0.0029 0.0291 0.046
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0306 0.1154
Treponema pallidum heat shock protein 90 0.0042 0.049 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0013 0.0052 0.0039
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0019 0.014 0.0259
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Onchocerca volvulus 0.0029 0.0291 0.0687
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.0291 0.076
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.0291 0.046
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0142 0.0267
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0819 0.1265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.0291 0.0421
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0019 0.014 0.0048
Plasmodium falciparum alpha/beta hydrolase, putative 0.0019 0.014 0.0208
Leishmania major hypothetical protein, conserved 0.0019 0.014 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0291 0.046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Onchocerca volvulus 0.0029 0.0291 0.0687
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0291 0.0421
Brugia malayi ORL1-like opioid receptor 0.0029 0.0291 0.0764
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus multilocularis g protein coupled receptor 0.0029 0.0291 0.046
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0019 0.014 0.0016
Brugia malayi UPF0017 protein CG3488 0.0019 0.014 0.0369
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.0291 0.046
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0093 0.0239
Leishmania major heat shock protein, putative 0.003 0.0306 0.1154
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Onchocerca volvulus 0.0029 0.0291 0.0687
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0019 0.014 0.0088
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0131
Brugia malayi neuropeptide F receptor 0.0029 0.0291 0.0764
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.0291 0.046
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Schistosoma mansoni choline dehydrogenase 0.0018 0.0124 0.0156
Mycobacterium ulcerans oxidoreductase 0.0019 0.014 0.0016
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0011 0.0031 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0221 0.0581
Echinococcus granulosus abhydrolase domain containing protein 0.0019 0.014 0.0221
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0251 0.0694
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Onchocerca volvulus 0.0029 0.0291 0.0687
Onchocerca volvulus 0.0018 0.0124 0.0247
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0019 0.014 0.0016
Entamoeba histolytica heat shock protein 90, putative 0.0045 0.0531 0.2233
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Mycobacterium ulcerans epoxide hydrolase EphA 0.0687 1 1
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0221 0.031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0221 0.0349
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.0291 0.0421
Loa Loa (eye worm) hypothetical protein 0.0141 0.1943 0.5105
Schistosoma mansoni hypothetical protein 0.0029 0.0291 0.0421
Leishmania major hydrolase, alpha/beta fold family, putative 0.0019 0.014 0.0259
Schistosoma mansoni heat shock protein 0.0045 0.0531 0.0804
Brugia malayi Synaptic glycoprotein SC2 0.0141 0.1943 0.5108
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0019 0.014 0.0221
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0221 0.031
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0221 0.031
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0141 0.1943 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.0291 0.0421
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.0291 0.046
Leishmania major hydrolase-like protein,esterase-like protein 0.0019 0.014 0.0259
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.0291 0.0421
Schistosoma mansoni vesicular acetylcholine transporter 0.0267 0.3804 0.6031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0221 0.0577
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0531 0.2367
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1444
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Echinococcus granulosus orexin receptor type 2 0.0029 0.0291 0.046
Brugia malayi nuclear receptor RXR 0.0011 0.0031 0.0083
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0434 0.1845
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.0291 0.046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Brugia malayi GnHR receptor homolog 0.0029 0.0291 0.0764
Echinococcus granulosus heat shock protein 90 0.0045 0.0531 0.0841
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0251 0.0686
Brugia malayi hypothetical protein 0.0013 0.0052 0.0136
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.0291 0.046
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Echinococcus granulosus Nuclear hormone receptor HR96 0.0011 0.0031 0.0047
Mycobacterium ulcerans bromoperoxidase BpoC 0.0019 0.014 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0131
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0019 0.014 0.0208
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0013 0.0052 0.0079
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0291 0.046
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Schistosoma mansoni amine GPCR 0.0029 0.0291 0.0421
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0221 0.0581
Schistosoma mansoni endoplasmin 0.0045 0.0531 0.0804
Echinococcus multilocularis endoplasmin 0.0042 0.049 0.0776
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0019 0.014 0.0365
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0141 0.1943 0.8035
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.0291 0.0764
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 0.8035
Echinococcus multilocularis cpg binding protein 0.0032 0.0339 0.0537
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0093 0.0144
Echinococcus granulosus thyroid hormone receptor alpha 0.0011 0.0031 0.0047
Onchocerca volvulus 0.0031 0.0313 0.0748
Echinococcus multilocularis abhydrolase domain containing 3 0.0019 0.014 0.0221
Brugia malayi sulfakinin receptor protein 0.0029 0.0291 0.0764
Loa Loa (eye worm) RNA binding protein 0.0126 0.1721 0.4521
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0019 0.014 0.0181
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0019 0.014 0.0365
Brugia malayi hypothetical protein 0.0016 0.01 0.0262
Brugia malayi nuclear hormone receptor family member odr-7 0.0011 0.0031 0.0083
Schistosoma mansoni hypothetical protein 0.0029 0.0291 0.0421
Onchocerca volvulus 0.0018 0.0124 0.0247
Mycobacterium ulcerans haloalkane dehalogenase 0.0019 0.014 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0221 0.0581
Trypanosoma cruzi glycosyl hydrolase, putative 0.0018 0.0124 0.0172
Chlamydia trachomatis phosphoglycolate phosphatase 0.0018 0.0124 0.5
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0267 0.3804 1
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0291 0.046
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0221 0.0581
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0531 0.2367
Echinococcus multilocularis fmrfamide receptor 0.0029 0.0291 0.046
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1604 0.4213
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.0291 0.046
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.0291 0.046
Schistosoma mansoni hypothetical protein 0.035 0.5026 0.7981
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.049 0.2145
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0019 0.014 0.0438
Loa Loa (eye worm) DR-78 0.0011 0.0031 0.0078
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0011 0.0031 0.0047
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.0291 0.0421
Echinococcus multilocularis heat shock protein 90 0.0039 0.0434 0.0687
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0018 0.0124 0.0195
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.0291 0.046
Echinococcus multilocularis synaptic glycoprotein sc2 0.0141 0.1943 0.3087
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0093 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0019 0.014 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.023 0.0596
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.1721 0.4524
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0013 0.0052 0.0079
Entamoeba histolytica hypothetical protein 0.0019 0.014 0.0088
Echinococcus multilocularis heat shock protein 90 0.0045 0.0531 0.0841
Brugia malayi nuclear hormone receptor 0.0024 0.0221 0.0581
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0141 0.1943 0.3087
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0531 0.2233
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.0291 0.046
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.0291 0.046
Mycobacterium ulcerans hydrolase 0.0019 0.014 0.0016
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.0291 0.046
Brugia malayi larval opioid receptor 0.0029 0.0291 0.0764
Loa Loa (eye worm) nuclear receptor NHR-67 0.0011 0.0031 0.0078
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0013 0.0052 0.0039
Plasmodium vivax hypothetical protein, conserved 0.0019 0.014 0.0208
Schistosoma mansoni biogenic amine receptor 0.0029 0.0291 0.0421
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.0291 0.0421
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0221 0.0581
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.049 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Plasmodium falciparum heat shock protein 90, putative 0.0172 0.2396 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0011 0.0031 0.0083
Onchocerca volvulus 0.0029 0.0291 0.0687
Schistosoma mansoni heat shock protein 0.0045 0.0531 0.0804
Onchocerca volvulus 0.0029 0.0291 0.0687
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0291 0.076
Schistosoma mansoni amine GPCR 0.0029 0.0291 0.0421
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0221 0.0349
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0039 0.0434 0.0687
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0221 0.0502
Schistosoma mansoni neuropeptide receptor 0.0029 0.0291 0.0421
Brugia malayi isocitrate dehydrogenase 0.0016 0.0093 0.0244
Plasmodium vivax heat shock protein 90, putative 0.003 0.0306 0.0928
Brugia malayi RNA binding protein 0.0126 0.1721 0.4524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.0291 0.046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0221 0.0349
Schistosoma mansoni cpg binding protein 0.0031 0.0313 0.0457
Trypanosoma brucei heat shock protein 90, putative 0.0045 0.0531 0.2367
Brugia malayi G-protein coupled receptor 0.0029 0.0291 0.0764
Mycobacterium ulcerans hypothetical protein 0.0141 0.1943 0.1841
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0267 0.3804 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0019 0.014 0.0221
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0018 0.0124 0.0195
Toxoplasma gondii heat shock protein 90, putative 0.0045 0.0531 0.1902
Echinococcus granulosus neuropeptide receptor 0.0029 0.0291 0.046
Schistosoma mansoni heat shock protein 0.003 0.0306 0.0446
Mycobacterium ulcerans proline iminopeptidase PIP 0.0019 0.014 0.0016
Brugia malayi Dopamine receptor protein 1 0.0029 0.0291 0.0764
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0717 0.2712
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0221 0.0581
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0221 0.031
Onchocerca volvulus 0.0029 0.0291 0.0687
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.0291 0.0764
Brugia malayi Serotonin receptor 0.0029 0.0291 0.0764
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0221 0.0349
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.0291 0.076
Entamoeba histolytica hypothetical protein 0.0036 0.0387 0.1444
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.0291 0.046
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.049 0.0401
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0141 0.1943 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0221 0.0581
Mycobacterium tuberculosis Probable exported protease 0.0019 0.014 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0011 0.0031 0.0007
Giardia lamblia Synaptic glycoprotein SC2 0.0141 0.1943 1
Mycobacterium ulcerans lipase/esterase 0.0019 0.014 0.0016
Brugia malayi orphan nuclear receptor NR2E1 0.0011 0.0031 0.0083
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.0291 0.076
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0018 0.0124 0.0323
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.0291 0.0421
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Echinococcus granulosus synaptic glycoprotein sc2 0.0141 0.1943 0.3087
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0221 0.0581
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0019 0.014 0.0221
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0531 0.2367
Brugia malayi hydrolase, alpha/beta fold family protein 0.0019 0.014 0.0369
Schistosoma mansoni amine GPCR 0.0029 0.0291 0.0421
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0018 0.0124 0.0327
Mycobacterium tuberculosis Possible phosphatase 0.0018 0.0124 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Plasmodium vivax endoplasmin, putative 0.0045 0.0531 0.1902
Schistosoma mansoni nuclear receptor 0.0011 0.0031 0.0007
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Echinococcus multilocularis serotonin receptor 0.0029 0.0291 0.046
Echinococcus granulosus abhydrolase domain containing protein 3 0.0019 0.014 0.0221
Loa Loa (eye worm) heat shock protein 90 0.0045 0.0531 0.1391
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0141 0.1943 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0387 0.0613
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Echinococcus multilocularis tar DNA binding protein 0.0126 0.1721 0.2734
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.023 0.0596
Brugia malayi conserved hypotetical protein 0.0011 0.0031 0.0083
Brugia malayi Alpha/beta hydrolase 0.0019 0.014 0.0369
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.0291 0.046
Trypanosoma brucei Heat shock protein 83, putative 0.0045 0.0531 0.2367
Plasmodium vivax hypothetical protein, conserved 0.0019 0.014 0.0208
Toxoplasma gondii heat shock protein HSP90 0.0045 0.0531 0.1902
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Brugia malayi hypothetical protein 0.0025 0.023 0.0604
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.0291 0.046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Echinococcus granulosus tar DNA binding protein 0.0126 0.1721 0.2734
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0019 0.014 0.0221
Brugia malayi nuclear receptor RXR 0.0013 0.0052 0.0136
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.0291 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.014 0.0259
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0078
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0023 0.0205 0.2199
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1721 0.2705
Mycobacterium ulcerans lignin peroxidase LipJ 0.0019 0.014 0.0016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.0291 0.0421
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Echinococcus granulosus hypothetical protein 0.0029 0.0291 0.046
Brugia malayi Dopamine receptor 0.0029 0.0291 0.0764
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.0291 0.0421
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.049 1
Loa Loa (eye worm) hydrolase 0.0019 0.014 0.0365
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Trypanosoma cruzi heat shock protein, putative 0.003 0.0306 0.1154
Schistosoma mansoni tar DNA-binding protein 0.0126 0.1721 0.2705
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.0291 0.0764
Mycobacterium tuberculosis Conserved protein 0.0019 0.014 0.0048
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.0291 0.0421
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.0291 0.0421
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0531 0.2367
Schistosoma mansoni histamine h1 receptor 0.0029 0.0291 0.0421
Brugia malayi hypothetical protein 0.0011 0.0031 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.014 0.0365
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0221 0.0349
Brugia malayi alpha/beta hydrolase 0.0019 0.014 0.0369
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.0291 0.046
Onchocerca volvulus 0.0029 0.0291 0.0687
Loa Loa (eye worm) hypothetical protein 0.0018 0.0124 0.0323
Echinococcus multilocularis neuropeptide receptor 0.0029 0.0291 0.046
Echinococcus multilocularis sex peptide receptor 0.0029 0.0291 0.046
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0306 0.0999
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0018 0.0124 0.0327
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.0291 0.046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0093 0.0105
Brugia malayi steroid hormone receptor 0.0024 0.0221 0.0581
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Schistosoma mansoni hypothetical protein 0.0435 0.629 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0221 0.0349
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0306 0.0928
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0221 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0221 0.0581
Brugia malayi RE15519p 0.0029 0.0291 0.0764
Brugia malayi hypothetical protein 0.0029 0.0291 0.0764
Schistosoma mansoni nuclear receptor nhr-48 0.0011 0.0031 0.0007
Mycobacterium ulcerans lipase/esterase 0.0019 0.014 0.0016
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Leishmania major heat shock protein 83-1 0.0045 0.0531 0.2367
Echinococcus granulosus g protein coupled receptor 0.0029 0.0291 0.046
Mycobacterium ulcerans heat shock protein 90 0.0042 0.049 0.037
Brugia malayi G-protein coupled receptor 0.0029 0.0291 0.0764
Echinococcus granulosus heat shock protein 0.0045 0.0531 0.0841
Loa Loa (eye worm) hypothetical protein 0.0029 0.0291 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.014 0.0259
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.0291 0.046
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1604 0.4213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0221 0.0349
Loa Loa (eye worm) hypothetical protein 0.0024 0.0221 0.0577
Schistosoma mansoni opsin-like receptor 0.0029 0.0291 0.0421
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0018 0.0124 0.0138

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 300 nM Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles ChEMBL. 2724295
IC50 (binding) = 300 nM Inhibition of active transport of [3H]-Acetylcholine using purified Torpedo californica synaptic vesicles ChEMBL. 2724295

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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