Detailed information for compound 256562

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 597.706 | Formula: C30H43N7O6
  • H donors: 6 H acceptors: 6 LogP: -0.97 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 3
  • SMILES: Oc1cccc(c1)C[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)O)C)C)Cc1ccccc1)CCCN=C(N)N)N(C)C
  • InChi: 1S/C30H43N7O6/c1-19(29(42)43)37(4)28(41)24(17-20-10-6-5-7-11-20)35-26(39)23(14-9-15-33-30(31)32)34-27(40)25(36(2)3)18-21-12-8-13-22(38)16-21/h5-8,10-13,16,19,23-25,38H,9,14-15,17-18H2,1-4H3,(H,34,40)(H,35,39)(H,42,43)(H4,31,32,33)/t19-,23-,24-,25-/m0/s1
  • InChiKey: UVCOBGJAENAZDA-KMAVCZJNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus opioid receptor, kappa 1 Starlite/ChEMBL References
Mus musculus opioid receptor, delta 1 Starlite/ChEMBL References
Mus musculus opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi hypothetical protein opioid receptor, kappa 1 380 aa 323 aa 20.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0614 0.2558 0.2558
Leishmania major cathepsin L-like protease 0.0043 0.0061 0.0061
Mycobacterium tuberculosis Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0584 0.2428 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0322 0.1283 0.5225
Leishmania major cathepsin L-like protease 0.0043 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0056
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.0868 0.3493
Loa Loa (eye worm) cathepsin B 0.0052 0.0102 0.0188
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0322 0.1283 0.1283
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0061 0.0411
Leishmania major hypothetical protein, conserved 0.0053 0.0105 0.0105
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.003 0.0031
Echinococcus granulosus calpain 7 C02 family 0.0197 0.0734 0.09
Echinococcus multilocularis calpain 7 (C02 family) 0.0197 0.0734 0.0897
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1882 0.8096 0.8096
Toxoplasma gondii cathepsin CPL 0.0043 0.0061 0.0076
Onchocerca volvulus 0.0043 0.0061 0.0411
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Schistosoma mansoni aldo-keto reductase 0.0322 0.1283 0.1579
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0053 0.0105 0.0129
Trypanosoma brucei aldo-keto reductase, putative 0.0322 0.1283 0.1283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Loa Loa (eye worm) oxidoreductase 0.0322 0.1283 0.237
Trypanosoma cruzi cysteine peptidase, putative 0.0043 0.0061 0.0061
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Brugia malayi intermediate filament protein 0.0031 0.0009 0.0011
Leishmania major cathepsin L-like protease 0.0089 0.0265 0.0265
Brugia malayi Cathepsin L-like precursor 0.0043 0.0061 0.0076
Leishmania major cathepsin L-like protease 0.0089 0.0265 0.0265
Onchocerca volvulus 0.0322 0.1283 0.9428
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0197 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.034 0.136 0.2513
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0056
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.1882 0.8096 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.1882 0.8096 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.003 0.0027
Leishmania major cathepsin L-like protease 0.0043 0.0061 0.0061
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0043 0.0061 0.0065
Echinococcus granulosus aldehyde reductase 0.0229 0.0875 0.1075
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0322 0.1283 0.1283
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Mycobacterium leprae Possible oxidoreductase 0.0093 0.0283 0.1053
Schistosoma mansoni lamin 0.0031 0.0009 0.0004
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1882 0.8096 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trypanosoma cruzi kinesin, putative 0.0144 0.0504 0.0504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Trypanosoma brucei calpain, putative 0.0053 0.0105 0.0105
Schistosoma mansoni potassium channel beta 0.0093 0.0283 0.0343
Echinococcus granulosus voltage gated potassium channel subunit 0.0093 0.0283 0.0343
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0043 0.0061 0.0114
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0093 0.0283 0.0283
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma brucei Calpain-like protein CALP1.3 0.0053 0.0105 0.0105
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0197 0.0734 0.0734
Trypanosoma brucei antigen, putative 0.0197 0.0734 0.0734
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0322 0.1283 0.1585
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Brugia malayi beta-lactamase 0.0036 0.003 0.0038
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.0265 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Plasmodium vivax aldehyde reductase, putative 0.0093 0.0283 0.0349
Leishmania major aldo-keto reductase-like protein 0.0322 0.1283 0.1283
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Schistosoma mansoni intermediate filament proteins 0.0031 0.0009 0.0004
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0061 0.0069
Trichomonas vaginalis aldo-keto reductase, putative 0.0093 0.0283 0.0343
Brugia malayi beta-lactamase family protein 0.0036 0.003 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0105 0.0122
Leishmania major cysteine peptidase A (CPA) 0.0043 0.0061 0.0061
Echinococcus multilocularis calpain 0.0197 0.0734 0.0897
Schistosoma mansoni aldo-keto reductase 0.0322 0.1283 0.1579
Loa Loa (eye worm) oxidoreductase 0.0322 0.1283 0.237
Leishmania major cathepsin L-like protease 0.0043 0.0061 0.0061
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Echinococcus multilocularis aldo keto reductase 0.0322 0.1283 0.1576
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Echinococcus granulosus aldo keto reductase 0.0322 0.1283 0.1579
Loa Loa (eye worm) oxidoreductase 0.0322 0.1283 0.237
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1882 0.8096 0.8096
Trypanosoma brucei cysteine peptidase, putative 0.0053 0.0105 0.0105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.0499 0.0609
Onchocerca volvulus 0.0322 0.1283 0.9428
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.1882 0.8096 1
Loa Loa (eye worm) hypothetical protein 0.0537 0.2219 0.4099
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Loa Loa (eye worm) hypothetical protein 0.0484 0.199 0.3675
Entamoeba histolytica calpain family cysteine protease, putative 0.0053 0.0105 0.0122
Echinococcus multilocularis calpain family protein 1, d 0.0393 0.159 0.1955
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1882 0.8096 0.8096
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1882 0.8096 1
Trichomonas vaginalis calpain, putative 0.0053 0.0105 0.0122
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0684 0.2861 0.3529
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.0265 0.0265
Echinococcus granulosus lamin dm0 0.0031 0.0009 0.0004
Toxoplasma gondii ABC1 family protein 0.0036 0.003 0.0038
Schistosoma mansoni calpain-7 (C02 family) 0.0197 0.0734 0.09
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0093 0.0283 0.0349
Trichomonas vaginalis aldo/keto reductase, putative 0.0322 0.1283 0.1579
Schistosoma mansoni pol-related 0.0322 0.1283 0.1579
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0684 0.2861 0.3534
Onchocerca volvulus 0.0322 0.1283 0.9428
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.003 0.0031
Brugia malayi NADH-dependent xylose reductase 0.0093 0.0283 0.0349
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Loa Loa (eye worm) cysteine protease 0.0043 0.0061 0.0114
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0197 0.0734 0.0734
Entamoeba histolytica cysteine protease, putative 0.0043 0.0061 0.0069
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Mycobacterium tuberculosis Probable oxidoreductase 0.0322 0.1283 0.5225
Loa Loa (eye worm) calpain D 0.0053 0.0105 0.0193
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0093 0.0283 0.0349
Trypanosoma brucei Calpain-like protein 2 0.0053 0.0105 0.0105
Leishmania major calpain family cysteine protease-like protein 0.0053 0.0105 0.0105
Echinococcus granulosus intermediate filament protein 0.0031 0.0009 0.0004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1268 0.5414 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0043 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Schistosoma mansoni lamin 0.0031 0.0009 0.0004
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1199 0.511 0.6308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0056
Plasmodium falciparum cysteine proteinase falcipain 3 0.0043 0.0061 0.0076
Echinococcus granulosus tm gpcr rhodopsin 0.0634 0.2642 0.3259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1199 0.511 0.6309
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.003 0.0031
Echinococcus granulosus cathepsin l cysteine peptidase 0.0043 0.0061 0.0069
Brugia malayi beta-lactamase family protein 0.0036 0.003 0.0038
Trypanosoma brucei kinesin, putative 0.0144 0.0504 0.0504
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Onchocerca volvulus 0.0043 0.0061 0.0411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Brugia malayi calpain 5 0.0144 0.0504 0.0623
Brugia malayi Cathepsin L-like cysteine proteinase 0.003 0.0006 0.0007
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0043 0.0061 0.0114
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0561 0.2327 0.287
Trichomonas vaginalis aldo/keto reductase, putative 0.0322 0.1283 0.1579
Echinococcus multilocularis cathepsin b 0.0143 0.0499 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0093 0.0283 0.0349
Loa Loa (eye worm) calpain 5 0.0144 0.0504 0.0932
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 0.8096
Trypanosoma cruzi aldo-keto reductase 0.0322 0.1283 0.1283
Onchocerca volvulus 0.034 0.136 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.003 0.0056
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0561 0.2327 0.287
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0056
Entamoeba histolytica cysteine proteinase, putative 0.0043 0.0061 0.0069
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0322 0.1283 0.1579
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Onchocerca volvulus 0.0093 0.0283 0.2046
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.1882 0.8096 1
Brugia malayi calpain family protein 1 0.0537 0.2219 0.2741
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.0105 0.0122
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 0.8096
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Echinococcus multilocularis aldo keto reductase 0.0322 0.1283 0.1576
Loa Loa (eye worm) oxidoreductase 0.0322 0.1283 0.237
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Echinococcus granulosus geminin 0.0192 0.0715 0.0876
Leishmania major hypothetical protein, conserved 0.0036 0.003 0.003
Echinococcus granulosus calpain A 0.0561 0.2327 0.287
Trypanosoma brucei calpain-like protein, putative 0.0197 0.0734 0.0734
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0192 0.0715 0.0876
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0052 0.0102 0.0119
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0614 0.2558 0.3159
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0093 0.0283 0.0343
Leishmania major cathepsin L-like protease 0.0043 0.0061 0.0061
Trichomonas vaginalis calpain, putative 0.0053 0.0105 0.0122
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1882 0.8096 1
Plasmodium falciparum calpain 0.0053 0.0105 0.0129
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 0.8096
Trypanosoma brucei Calpain-like protein 1.2 0.0053 0.0105 0.0105
Plasmodium vivax hypothetical protein, conserved 0.0036 0.003 0.0038
Leishmania major hypothetical protein, unknown function 0.0053 0.0105 0.0105
Toxoplasma gondii cathepsin B 0.0052 0.0102 0.0126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Leishmania major prostaglandin f synthase, putative 0.0322 0.1283 0.1283
Echinococcus granulosus calpain 5 0.0197 0.0734 0.09
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.0105 0.0122
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Loa Loa (eye worm) fibroinase 0.0043 0.0061 0.0114
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1882 0.8096 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0052 0.0102 0.0102
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.0105 0.0122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.0499 0.0609
Brugia malayi cathepsin L-like precursor 0.003 0.0006 0.0007
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1882 0.8096 0.8096
Echinococcus multilocularis cathepsin b 0.0143 0.0499 0.0606
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0043 0.0061 0.0069
Onchocerca volvulus 0.0036 0.003 0.0183
Brugia malayi Cathepsin L-like precursor 0.0043 0.0061 0.0076
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1882 0.8096 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.003 0.003
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0322 0.1283 0.1579
Schistosoma mansoni hypothetical protein 0.0053 0.0105 0.0122
Onchocerca volvulus 0.0322 0.1283 0.9428
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0114
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0614 0.2558 0.2558
Onchocerca volvulus 0.0036 0.003 0.0183
Trypanosoma brucei prostaglandin f synthase 0.0322 0.1283 0.1283
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.1882 0.8096 0.5
Echinococcus granulosus cathepsin L cysteine proteinase 0.0043 0.0061 0.0069
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0053 0.0105 0.0105
Trypanosoma brucei Calpain-like protein 1.1 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.1268 0.5414 1
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.1882 0.8096 0.8096
Echinococcus granulosus cathepsin b 0.0143 0.0499 0.0609
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0561 0.2327 0.2867
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Loa Loa (eye worm) oxidoreductase 0.0322 0.1283 0.237
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0322 0.1283 0.1585
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.0043 0.0061 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.003 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.003 0.0031
Echinococcus multilocularis calpain A 0.0561 0.2327 0.2867
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.003 0.003
Echinococcus multilocularis geminin 0.0192 0.0715 0.0873
Toxoplasma gondii aldose reductase, putative 0.0322 0.1283 0.1585
Onchocerca volvulus 0.0043 0.0061 0.0411
Echinococcus multilocularis cysteine protease 0.0043 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0016
Brugia malayi Cathepsin L-like precursor 0.0043 0.0061 0.0076
Echinococcus granulosus aldo keto reductase 0.0322 0.1283 0.1579
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Brugia malayi Cathepsin L-like precursor 0.0043 0.0061 0.0076
Loa Loa (eye worm) hypothetical protein 0.0143 0.0499 0.0921
Plasmodium vivax calpain, putative 0.0197 0.0734 0.0907
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0052 0.0102 0.0102
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0143 0.0499 0.0609
Onchocerca volvulus 0.0031 0.0009 0.0022
Onchocerca volvulus 0.0031 0.0009 0.0022
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Plasmodium vivax vivapain-2 0.0043 0.0061 0.0076
Onchocerca volvulus 0.0043 0.0061 0.0411
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0127 0.0127
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0614 0.2558 0.2558
Trypanosoma cruzi conserved protein 0.0053 0.0105 0.0105
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Schistosoma mansoni hypothetical protein 0.0192 0.0715 0.0876
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2318 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0052 0.0102 0.0119
Leishmania major calpain protease-like protein 0.0053 0.0105 0.0105
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Trichomonas vaginalis calpain, putative 0.0053 0.0105 0.0122
Entamoeba histolytica alcohol dehydrogenase, putative 0.0093 0.0283 0.0343
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1199 0.511 0.6309
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 0.8096
Trichomonas vaginalis hypothetical protein 0.0053 0.0105 0.0122
Onchocerca volvulus 0.0043 0.0061 0.0411
Trypanosoma cruzi cysteine peptidase, putative 0.0089 0.0265 0.0265
Onchocerca volvulus 0.0322 0.1283 0.9428
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1199 0.511 0.944
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Entamoeba histolytica aldose reductase, putative 0.0322 0.1283 0.1579
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.003 0.0038
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.1882 0.8096 0.5
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Echinococcus multilocularis calpain 5 0.0197 0.0734 0.0897
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0614 0.2558 0.2558
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0634 0.2642 0.3257
Leishmania major cathepsin L-like protease 0.0089 0.0265 0.0265
Onchocerca volvulus Cathepsin F homolog 0.0043 0.0061 0.0411
Mycobacterium ulcerans oxidoreductase 0.0322 0.1283 0.1553
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Echinococcus multilocularis cysteine protease 0.0043 0.0061 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0614 0.2558 0.2558
Toxoplasma gondii hypothetical protein 0.0053 0.0105 0.0129
Mycobacterium leprae Conserved hypothetical protein 0.0229 0.0875 0.3523
Brugia malayi calpain D 0.0053 0.0105 0.0129
Echinococcus multilocularis aldo keto reductase 0.0322 0.1283 0.1576
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.2318 1 1
Onchocerca volvulus 0.0043 0.0061 0.0411
Loa Loa (eye worm) hypothetical protein 0.1199 0.511 0.944
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0011
Brugia malayi calpain 7 0.0197 0.0734 0.0907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0043 0.0061 0.0069
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0197 0.0734 0.0734
Brugia malayi calpain family protein 1 0.0537 0.2219 0.2741
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0537 0.2219 0.2736
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.0105 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trichomonas vaginalis aldo-keto reductase, putative 0.0093 0.0283 0.0343
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.1882 0.8096 0.8096
Trypanosoma brucei aldo/keto reductase, putative 0.0093 0.0283 0.0283
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Schistosoma mansoni Mername-AA248 (C02 family) 0.0197 0.0734 0.09
Echinococcus granulosus cathepsin b 0.0143 0.0499 0.0609
Echinococcus granulosus calpain A 0.0197 0.0734 0.09
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0052 0.0102 0.0102
Brugia malayi calpain 5 0.0053 0.0105 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Schistosoma mansoni cathepsin F (C01 family) 0.0043 0.0061 0.0069
Echinococcus granulosus cathepsin l1 0.0043 0.0061 0.0069
Toxoplasma gondii aldo-keto reductase 0.0093 0.0283 0.0349
Echinococcus granulosus hypothetical protein 0.0322 0.1283 0.1579
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0053 0.0105 0.0105
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1882 0.8096 1
Trypanosoma brucei hypothetical protein 0.0053 0.0105 0.0105
Loa Loa (eye worm) calpain family protein 1 0.0393 0.159 0.2937
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Echinococcus granulosus calpain 0.0197 0.0734 0.09
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Schistosoma mansoni calpain (C02 family) 0.0197 0.0734 0.09
Onchocerca volvulus 0.0036 0.003 0.0183
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Schistosoma mansoni calpain C (C02 family) 0.0197 0.0734 0.09
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.003 0.0031
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.1882 0.8096 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0322 0.1283 0.1585
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0322 0.1283 0.1585
Giardia lamblia Aldose reductase 0.0322 0.1283 0.1477
Onchocerca volvulus 0.0043 0.0061 0.0411
Echinococcus multilocularis cathepsin L cysteine protease 0.0043 0.0061 0.0065
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0043 0.0061 0.0076
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1882 0.8096 0.8096
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.003 0.0056
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.1882 0.8096 1
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0053 0.0105 0.0105
Schistosoma mansoni cathepsin F (C01 family) 0.0043 0.0061 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Loa Loa (eye worm) hypothetical protein 0.0053 0.0105 0.0193
Loa Loa (eye worm) calpain 0.0197 0.0734 0.1356
Trypanosoma brucei calpain, putative 0.0053 0.0105 0.0105
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.0105 0.0122
Trypanosoma cruzi kinesin, putative 0.0144 0.0504 0.0504
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0093 0.0283 0.0343
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0197 0.0734 0.0734
Echinococcus multilocularis aldo keto reductase 0.0322 0.1283 0.1576
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0009 0.0011
Brugia malayi Cathepsin L-like precursor 0.003 0.0006 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0283 0.0343
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0009 0.0016
Brugia malayi Cathepsin L-like precursor 0.0043 0.0061 0.0076
Echinococcus multilocularis voltage gated potassium channel subunit 0.0093 0.0283 0.0339
Echinococcus multilocularis aldehyde reductase 0.0229 0.0875 0.1071
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.003 0.0031
Schistosoma mansoni calpain-7 (C02 family) 0.0197 0.0734 0.09
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0043 0.0061 0.0076
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0053 0.0105 0.0122
Echinococcus granulosus aldo keto reductase 0.0322 0.1283 0.1579
Entamoeba histolytica aldose reductase, putative 0.0322 0.1283 0.1579
Schistosoma mansoni calpain-2 (C02 family) 0.0053 0.0105 0.0122
Trichomonas vaginalis aldo-keto reductase, putative 0.0093 0.0283 0.0343
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0093 0.0283 0.0349
Entamoeba histolytica protein kinase, putative 0.0144 0.0504 0.0616
Trichomonas vaginalis esterase, putative 0.0036 0.003 0.0031
Trypanosoma cruzi aldo/keto reductase, putative 0.0093 0.0283 0.0283
Trypanosoma brucei calpain-like protein, putative 0.0197 0.0734 0.0734
Entamoeba histolytica calpain large subunit domain III containing protein 0.0144 0.0504 0.0616
Onchocerca volvulus Cathepsin L homolog 0.0043 0.0061 0.0411
Echinococcus granulosus lamin 0.0031 0.0009 0.0004
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1882 0.8096 1
Mycobacterium leprae Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) 0.0584 0.2428 1
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0197 0.0734 0.0734
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0561 0.2327 0.287
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0009 0.0016
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.1882 0.8096 0.8096
Onchocerca volvulus 0.0322 0.1283 0.9428
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0093 0.0283 0.0523
Loa Loa (eye worm) calpain family protein 1 0.0537 0.2219 0.4099
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0197 0.0734 0.0734
Plasmodium falciparum aldo-keto reductase, putative 0.0093 0.0283 0.0349
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0076 0.0209 0.0209
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0197 0.0734 0.0734
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0322 0.1283 0.1579
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0011
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0143 0.0499 0.0609
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Giardia lamblia Aldose reductase 0.0322 0.1283 0.1477
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.1882 0.8096 0.5
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0053 0.0105 0.0105
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0143 0.0499 0.0499
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0322 0.1283 0.1579
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.1298 0.5543 0.6807
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.1882 0.8096 1
Trypanosoma cruzi cruzipain precursor, putative 0.0089 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0036 0.003 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Brugia malayi Cathepsin L-like precursor 0.0043 0.0061 0.0076
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.1199 0.511 0.944
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0043 0.0061 0.0065
Leishmania major kinesin, putative 0.0144 0.0504 0.0504
Brugia malayi cathepsin B-like cysteine proteinase 0.0143 0.0499 0.0616
Trypanosoma cruzi aldo/keto reductase, putative 0.0322 0.1283 0.1283
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.2318 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.1199 0.511 0.6309
Trypanosoma brucei calpain-like protein, putative 0.0197 0.0734 0.0734
Echinococcus multilocularis hypothetical protein 0.0197 0.0734 0.0897
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0043 0.0061 0.0069
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Plasmodium vivax vivapain-2 0.0043 0.0061 0.0076
Loa Loa (eye worm) hypothetical protein 0.0393 0.159 0.2937
Brugia malayi Cathepsin L-like precursor 0.003 0.0006 0.0007
Entamoeba histolytica aldose reductase, putative 0.0322 0.1283 0.1579
Loa Loa (eye worm) ctsf protein 0.0043 0.0061 0.0114
Mycobacterium ulcerans hypothetical protein 0.0093 0.0283 0.0313
Entamoeba histolytica alcohol dehydrogenase, putative 0.0093 0.0283 0.0343
Echinococcus multilocularis cathepsin L cysteine protease 0.0043 0.0061 0.0065
Plasmodium falciparum aldehyde reductase, putative 0.0093 0.0283 0.0349
Trichomonas vaginalis aldo-keto reductase, putative 0.0322 0.1283 0.1579
Trypanosoma brucei calpain-like protein, putative 0.0197 0.0734 0.0734
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0053 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0322 0.1283 0.237
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0053 0.0105 0.0105
Mycobacterium tuberculosis Conserved protein 0.0093 0.0283 0.1053
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0012
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.1882 0.8096 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0089 0.0265 0.0265
Trichomonas vaginalis aldo/keto reductase, putative 0.0322 0.1283 0.1579
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0322 0.1283 0.1576

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 101 nM Binding affinity of the compound towards Opioid receptor mu 1 by the displacement of [3H]-DAMGO in mouse spinal cord ChEMBL. 12408719
IC50 (binding) = 101 nM Binding affinity of the compound towards Opioid receptor mu 1 by the displacement of [3H]-DAMGO in mouse spinal cord ChEMBL. 12408719
IC50 (binding) > 1000 nM Binding affinity of the compound towards Opioid receptor delta 1 by the displacement of [3H]-deltorphin-II in mouse spinal cord ChEMBL. 12408719
IC50 (binding) > 1000 nM Binding affinity of the compound towards Opioid receptor kappa 1 by the displacement of [3H]-U-69,593 in mouse spinal cord ChEMBL. 12408719
IC50 (binding) > 1000 nM Binding affinity of the compound towards Opioid receptor delta 1 by the displacement of [3H]-deltorphin-II in mouse spinal cord ChEMBL. 12408719
IC50 (binding) > 1000 nM Binding affinity of the compound towards Opioid receptor kappa 1 by the displacement of [3H]-U-69,593 in mouse spinal cord ChEMBL. 12408719
MPE (functional) = 13 % Invivo antinociceptive activity of the compound expressed as % Maximum possible effect administered preorally at a dose of 10 mg/kg in mice ChEMBL. 12408719
MPE (functional) = 13 % Invivo antinociceptive activity of the compound expressed as % Maximum possible effect administered preorally at a dose of 10 mg/kg in mice ChEMBL. 12408719
MPE (functional) = 29 % Invivo antinociceptive activity of the compound expressed as % Maximum possible effect administered subcutaneously at a dose of 1 mg/kg in mice ChEMBL. 12408719
MPE (functional) = 29 % Invivo antinociceptive activity of the compound expressed as % Maximum possible effect administered subcutaneously at a dose of 1 mg/kg in mice ChEMBL. 12408719
ND (functional) 0 Invivo antinociceptive activity of the compound expressed as ED50 administered subcutaneously for tail pressure test in mice; ND is not determined ChEMBL. 12408719
ND (functional) 0 Invivo antinociceptive activity of the compound expressed as ED50 administered preorally for tail pressure test in mice; ND is not determined ChEMBL. 12408719
Relative potency (binding) = 0.11 M Relative potency of the compound against [3H]-DAMGO and that of the Opioid receptor mu 1 ChEMBL. 12408719
Relative potency (binding) = 0.11 M Relative potency of the compound against [3H]-DAMGO and that of the Opioid receptor mu 1 ChEMBL. 12408719

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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