Detailed information for compound 258356

Basic information

Technical information
  • TDR Targets ID: 258356
  • Name: 1'-[4-(diethylamino)butyl]spiro[2,3-dihydro-1 H-naphthalene-4,3'-pyrrolidine]-2',5'-dione
  • MW: 342.475 | Formula: C21H30N2O2
  • H donors: 0 H acceptors: 2 LogP: 3.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCCN1C(=O)CC2(C1=O)CCCc1c2cccc1)CC
  • InChi: 1S/C21H30N2O2/c1-3-22(4-2)14-7-8-15-23-19(24)16-21(20(23)25)13-9-11-17-10-5-6-12-18(17)21/h5-6,10,12H,3-4,7-9,11,13-16H2,1-2H3
  • InChiKey: HXJLUZFQBQXDAD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[4-(diethylamino)butyl]spiro[pyrrolidine-3,1'-tetralin]-2,5-dione
  • 1-[4-(diethylamino)butyl]spiro[pyrrolidine-3,1'-tetralin]-2,5-quinone
  • 1'-(4-diethylaminobutyl)spiro[2,3-dihydro-1H-naphthalene-4,3'-pyrrolidine]-2',5'-dione
  • 1-(4-diethylaminobutyl)spiro[pyrrolidine-3,1'-tetralin]-2,5-dione
  • 1-(4-diethylaminobutyl)spiro[pyrrolidine-3,1'-tetralin]-2,5-quinone
  • 28309-59-3
  • 28309-58-2
  • 74246-98-3
  • RAC 309I
  • Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(diethylamino)butyl)-, (-)-
  • BRN 1550453
  • RAC 309II
  • Spiro(naphthalene-1(2H),3'-pyrrolidine)-2',5'-dione, 3,4-dihydro-1'-(4-(diethylamino)butyl)-, (+)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0093 0.0785 0.0784
Schistosoma mansoni adenoreceptor 0.0033 0.0132 0.0132
Echinococcus granulosus hypothetical protein 0.0923 0.9842 0.9842
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0061 0.0432 0.0431
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0033 0.0046
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.003 0.0029
Brugia malayi AKH receptor 0.0033 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0033 0.0132 0.0132
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0034 0.0146 0.0233
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0024 0.003 0.003
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0046 0.0275 0.0274
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0072 0.0344
Onchocerca volvulus 0.0033 0.0132 0.0189
Schistosoma mansoni voltage-gated cation channel 0.0938 1 1
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.003 0.0029
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0033 0.0132 0.0131
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0025 0.004 0.0039
Echinococcus multilocularis conserved hypothetical protein 0.0024 0.003 0.0029
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0047 0.0282 0.0424
Brugia malayi G protein-coupled receptor F59B2.13 0.0033 0.0132 0.0132
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0046 0.0275 0.1322
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Schistosoma mansoni myosin xvIII 0.0033 0.0132 0.0132
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0022 0.0007 0.0006
Onchocerca volvulus 0.0033 0.0132 0.0189
Brugia malayi cation channel family protein 0.0024 0.003 0.003
Onchocerca volvulus 0.0628 0.6624 0.9548
Brugia malayi Tyrosine-protein kinase abl-1 0.0061 0.0432 0.0432
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0082 0.0661 0.1277
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.016 0.1521 0.7328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0033 0.0032
Echinococcus granulosus neuroglian 0.0053 0.0352 0.0351
Toxoplasma gondii transporter, cation channel family protein 0.0196 0.1913 0.5848
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0146 0.0219
Loa Loa (eye worm) hypothetical protein 0.0043 0.0236 0.0235
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0132 0.0131
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0025 0.004 0.0056
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0024 0.003 0.0029
Schistosoma mansoni formin binding protein and related proteins 0.0021 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0024 0.003 0.0029
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0173 0.1655 0.1654
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.0236 0.0236
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0033 0.0132 0.0131
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0023 0.0018 0.0017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0432 0.0431
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0034 0.0146 0.07
Onchocerca volvulus 0.004 0.0203 0.029
Onchocerca volvulus 0.004 0.0203 0.029
Echinococcus granulosus roundabout 2 0.0025 0.004 0.0039
Loa Loa (eye worm) STAT protein 0.0022 0.0007 0.0006
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0022 0.0013 0.0013
Echinococcus multilocularis neuroglian 0.0025 0.004 0.0039
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0033 0.0033
Schistosoma mansoni C-fyn 0.0021 0.0001 0.0001
Loa Loa (eye worm) ryanodine receptor 0.0024 0.003 0.0029
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0132 0.0131
Echinococcus granulosus biogenic amine 5HT receptor 0.0033 0.0132 0.0131
Echinococcus granulosus tyrosine protein kinase ABL1 0.004 0.0203 0.0201
Echinococcus granulosus tachykinin peptides receptor 99D 0.0033 0.0132 0.0131
Schistosoma mansoni cell polarity protein 0.0021 0.0001 0.0001
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0275 0.1322
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0033 0.0132 0.0132
Brugia malayi hypothetical protein 0.007 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.003 0.0029
Schistosoma mansoni roundabout 0.0025 0.004 0.004
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0152 0.1433 0.1433
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0432 0.0431
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0042 0.0234 0.0234
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0033 0.0032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0033 0.0032
Echinococcus multilocularis conserved hypothetical protein 0.089 0.9482 0.9482
Brugia malayi sulfakinin receptor protein 0.0033 0.0132 0.0132
Schistosoma mansoni tensin-related 0.0022 0.0007 0.0007
Brugia malayi hypothetical protein 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0146 0.0219
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0211 0.2076 0.2076
Echinococcus multilocularis tyrosine protein kinase ABL1 0.004 0.0203 0.0201
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.063 0.6639 1
Onchocerca volvulus 0.004 0.0203 0.029
Echinococcus granulosus growth factor receptor bound protein 2 0.0043 0.0236 0.0235
Echinococcus multilocularis voltage dependent calcium channel 0.0938 1 1
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0319 0.325 1
Echinococcus granulosus g protein coupled receptor 0.0033 0.0132 0.0131
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0033 0.0032
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.004 0.0039
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.003 0.0029
Brugia malayi prolyl oligopeptidase family protein 0.0152 0.1433 0.1433
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Echinococcus granulosus hemicentin 1 0.0025 0.004 0.0039
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0152 0.1433 0.2065
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0275 0.1322
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0033 0.0032
Echinococcus multilocularis transfer RNA-Gly 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0233
Schistosoma mansoni suppressor of cytokine signaling 0.0022 0.0007 0.0007
Brugia malayi RhoGAP domain containing protein 0.0022 0.0007 0.0007
Trypanosoma cruzi oligopeptidase b 0.0047 0.0282 0.0424
Echinococcus granulosus SH2 motif 0.0022 0.0007 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0195 0.0194
Echinococcus granulosus N chimaerin 0.0022 0.0007 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0132 0.0132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0033 0.0032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0275 0.1322
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0022 0.0007 0.0006
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.003 0.0029
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0056 0.0384 0.0383
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Echinococcus multilocularis neuropeptide s receptor 0.0033 0.0132 0.0131
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0024 0.003 0.003
Schistosoma mansoni tensin 0.0022 0.0007 0.0007
Schistosoma mansoni 60S ribosomal protein L21 0.0024 0.003 0.003
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0041 0.0218 0.1343
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.015 0.1413 0.2127
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.003 0.0029
Brugia malayi larval opioid receptor 0.0033 0.0132 0.0132
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0024 0.003 0.0029
Echinococcus granulosus dro:myosuppressin receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0132 0.0131
Schistosoma mansoni opsin-like receptor 0.0033 0.0132 0.0132
Echinococcus granulosus ryanodine receptor 44f 0.0024 0.003 0.0029
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0132 0.0131
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0024 0.003 0.003
Echinococcus multilocularis orexin receptor type 2 0.0033 0.0132 0.0131
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0024 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Brugia malayi SH3 domain containing protein 0.0021 0.0001 0.0001
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.003 0.0029
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0033 0.0132 0.0131
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Mycobacterium ulcerans carbonic anhydrase 0.0189 0.1829 0.521
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0034 0.0146 0.0146
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.063 0.6639 0.6638
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0195 0.0194
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0072 0.0072
Schistosoma mansoni biogenic amine receptor 0.0033 0.0132 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0033 0.0033
Echinococcus multilocularis tyrosine kinase 0.004 0.0203 0.0201
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0173 0.1655 0.1654
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0152 0.1433 0.1432
Brugia malayi tRNA modification GTPase TrmE family protein 0.0022 0.0007 0.0007
Echinococcus granulosus sodium channel protein 0.0024 0.003 0.0029
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0029 0.0085 0.0084
Echinococcus granulosus shaker cognate 0.0024 0.003 0.0029
Brugia malayi neuropeptide F receptor 0.0033 0.0132 0.0132
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0024 0.003 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0132 0.0131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Toxoplasma gondii hypothetical protein 0.0319 0.325 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus tyrosine protein kinase Src42A 0.0061 0.0432 0.0431
Schistosoma mansoni transient receptor potential channel 0.0024 0.003 0.003
Echinococcus granulosus orexin receptor type 2 0.0033 0.0132 0.0131
Schistosoma mansoni amine GPCR 0.0033 0.0132 0.0132
Brugia malayi Variant SH3 domain containing protein 0.0023 0.0018 0.0018
Onchocerca volvulus 0.0022 0.0007 0.0008
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0089 0.0746 0.0746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0033 0.0032
Echinococcus granulosus neuropeptide Y receptor 0.0033 0.0132 0.0131
Onchocerca volvulus 0.0024 0.0033 0.0046
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0024 0.003 0.0044
Echinococcus granulosus signal transduction protein lnk realted 0.0022 0.0007 0.0006
Schistosoma mansoni sorting nexin 0.0021 0.0001 0.0001
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0432 0.0431
Echinococcus granulosus SH2 domain containing protein 7 0.0022 0.0007 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0033 0.0033
Echinococcus granulosus defective proboscis extension response 0.0042 0.0234 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0033 0.0032
Brugia malayi Transient-receptor-potential like protein 0.0024 0.003 0.003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0558 0.5861 0.5861
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0938 1 1
Echinococcus multilocularis calcium activated potassium channel 0.0026 0.0056 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0033 0.0032
Schistosoma mansoni coup transcription factor 0.0024 0.0033 0.0033
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.015 0.1413 0.1413
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0033 0.0033
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0036 0.0161 0.016
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0072 0.0344
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0118 0.1062 0.1061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0233
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.015 0.1413 0.2127
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0432 0.0431
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0118 0.1062 0.3204
Echinococcus granulosus neuropeptide receptor A26 0.0033 0.0132 0.0131
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0033 0.0132 0.0132
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0061 0.0432 0.0431
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0022 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0033 0.0132 0.0132
Loa Loa (eye worm) calcium channel 0.0938 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0132 0.0132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0702 0.7432 0.7432
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0398 0.411 0.411
Echinococcus granulosus expressed conserved protein 0.0022 0.0007 0.0006
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0938 1 1
Echinococcus granulosus tyrosine kinase 0.004 0.0203 0.0201
Schistosoma mansoni signal transduction protein lnk-related 0.0022 0.0007 0.0007
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0132 0.0131
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0118 0.1062 0.1061
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Trypanosoma cruzi oligopeptidase b 0.0047 0.0282 0.0424
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Brugia malayi Cyclic-nucleotide gated cation channel 0.0024 0.003 0.003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0033 0.0032
Schistosoma mansoni tyrosine kinase 0.0061 0.0432 0.0432
Schistosoma mansoni neuropeptide receptor 0.0033 0.0132 0.0132
Echinococcus granulosus two pore calcium channel protein 1 0.0024 0.003 0.0029
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0938 1 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.003 0.003
Echinococcus granulosus sex peptide receptor 0.0033 0.0132 0.0131
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0033 0.0046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Schistosoma mansoni shc transforming protein 0.0022 0.0007 0.0007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0132 0.0132
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.1062 0.1062
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0072 0.0344
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0027 0.0067 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0033 0.0033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0033 0.0033
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0034 0.0146 0.07
Echinococcus multilocularis roundabout 2 0.0025 0.004 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.006 0.0423 0.0422
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Brugia malayi STAT protein, DNA binding domain containing protein 0.0022 0.0007 0.0007
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.003 0.0029
Echinococcus multilocularis Immunoglobulin 0.0042 0.0234 0.0233
Schistosoma mansoni voltage-dependent calcium channel 0.0024 0.003 0.003
Echinococcus multilocularis allatostatin A receptor 0.0033 0.0132 0.0131
Schistosoma mansoni opsin-like receptor 0.0033 0.0132 0.0132
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0571 0.5994 0.9029
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus tyrosine kinase 0.004 0.0203 0.0201
Leishmania major oligopeptidase b 0.0047 0.0282 0.0424
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0319 0.325 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0024 0.003 0.0029
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0146 0.0361
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0024 0.003 0.003
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0132 0.0132
Echinococcus granulosus twitchin 0.0056 0.0378 0.0377
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0042 0.0234 0.0233
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0033 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0033 0.0032
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0061 0.0432 0.0431
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.004 0.0039
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.003 0.0029
Echinococcus multilocularis acylamino acid releasing enzyme 0.0028 0.0072 0.0071
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.003 0.0029
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0033 0.0132 0.0131
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Brugia malayi Peroxidasin 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0022 0.0007 0.0007
Echinococcus multilocularis N chimaerin 0.0022 0.0007 0.0006
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.003 0.0029
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0132 0.0131
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0033 0.0132 0.0131
Onchocerca volvulus Prolyl endopeptidase homolog 0.0086 0.0714 0.1028
Echinococcus granulosus g-protein coupled receptor 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.007 0.0538 0.0537
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0033 0.0132 0.0131
Echinococcus multilocularis SH2 motif 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0083 0.0682 0.0681
Echinococcus granulosus lachesin 0.0025 0.004 0.0039
Schistosoma mansoni dihydroorotate dehydrogenase 0.0118 0.1062 0.1062
Schistosoma mansoni amine GPCR 0.0033 0.0132 0.0132
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0118 0.1062 0.1061
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0558 0.5861 0.5861
Echinococcus multilocularis shaker cognate 0.0024 0.003 0.0029
Echinococcus granulosus Dipeptidyl peptidase 9 0.015 0.1413 0.1412
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0033 0.0032
Schistosoma mansoni biogenic amine receptor 0.0033 0.0132 0.0132
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.003 0.0029
Leishmania major hypothetical protein, unknown function 0.0024 0.003 0.0044
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0033 0.0132 0.0132
Entamoeba histolytica protein kinase, putative 0.0024 0.0033 0.0156
Brugia malayi ecdysteroid receptor 0.0024 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0196 0.1913 0.1912
Echinococcus granulosus tyrosine protein kinase Lyn 0.0063 0.0458 0.0457
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0146 0.0219
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0233
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0028 0.0072 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0195 0.0195
Schistosoma mansoni opsin-like receptor 0.0033 0.0132 0.0132
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0039 0.0195 0.0194
Loa Loa (eye worm) hypothetical protein 0.0938 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0203 0.0201
Schistosoma mansoni neuropeptide receptor 0.0033 0.0132 0.0132
Toxoplasma gondii hypothetical protein 0.0173 0.1655 0.5046
Brugia malayi follicle stimulating hormone receptor 0.0132 0.1212 0.1212
Brugia malayi G protein-coupled receptor 0.0033 0.0132 0.0132
Echinococcus granulosus suppressor of cytokine signaling 7 0.0022 0.0007 0.0006
Entamoeba histolytica SH2 domain containing protein 0.0022 0.0007 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0132 0.0131
Brugia malayi nuclear hormone receptor 0.0024 0.0033 0.0033
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0036 0.0161 0.016
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0033 0.0132 0.0132
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0178 0.1714 0.8257
Loa Loa (eye worm) prolyl oligopeptidase 0.0028 0.0072 0.0071
Echinococcus granulosus prolyl endopeptidase 0.0086 0.0714 0.0713
Echinococcus multilocularis tensin 0.0022 0.0007 0.0006
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.003 0.003
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0195 0.0194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0024 0.003 0.0029
Brugia malayi prolyl oligopeptidase family protein 0.015 0.1413 0.1413
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0033 0.0046
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0938 1 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Trypanosoma brucei oligopeptidase b 0.0047 0.0282 0.0424
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.003 0.0029
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0001 0.0001
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0021 0.0001 0.0001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0033 0.0132 0.0131
Brugia malayi neuropeptide F receptor 0.0033 0.0132 0.0132
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0938 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0022 0.0007 0.0008
Schistosoma mansoni calcium-activated potassium channel 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Echinococcus granulosus TRP transient receptor potential channel 0.0024 0.003 0.0029
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0033 0.0033
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0661 0.3182
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0146 0.0219
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0072 0.0344
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0558 0.5861 0.5861
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0036 0.0161 0.016
Brugia malayi Spectrin alpha chain 0.0021 0.0001 0.0001
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0211 0.2076 1
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0072 0.0107
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0034 0.0146 0.07
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0024 0.003 0.0029
Toxoplasma gondii hypothetical protein 0.0028 0.0072 0.0132
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.015 0.1413 0.2127
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0432 0.0431
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0028 0.0072 0.0132
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0508 0.2443
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.003 0.003
Loa Loa (eye worm) SH2 domain-containing protein 0.0022 0.0007 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.003 0.0139
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0028 0.0072 0.0072
Onchocerca volvulus 0.0024 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Echinococcus multilocularis transient receptor potential cation channel 0.0024 0.003 0.0029
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.004 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0017
Brugia malayi RE15519p 0.0033 0.0132 0.0132
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Brugia malayi ORL1-like opioid receptor 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Brugia malayi Dopamine receptor protein 1 0.0033 0.0132 0.0132
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.0236 0.0235
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.003 0.0029
Brugia malayi protein-tyrosine kinase 0.0021 0.0001 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Echinococcus granulosus two pore calcium channel protein 2 0.0024 0.003 0.0029
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0938 1 1
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.063 0.6639 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0086 0.0714 0.1074
Echinococcus granulosus c src tyrosine kinase 0.0061 0.0432 0.0431
Plasmodium falciparum dihydroorotate dehydrogenase 0.0118 0.1062 0.3113
Loa Loa (eye worm) voltage-dependent calcium channel 0.0196 0.1913 0.1912
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0033 0.0132 0.0132
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.003 0.003
Echinococcus multilocularis mitogen activated protein kinase 14 0.063 0.6639 0.6638
Schistosoma mansoni nephrin 0.0053 0.0352 0.0352
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0025 0.004 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.003 0.0029
Schistosoma mansoni eps8-related protein 0.0021 0.0001 0.0001
Onchocerca volvulus Tyrosine kinase homolog 0.0657 0.6937 1
Schistosoma mansoni tensin-related 0.0022 0.0007 0.0007
Echinococcus multilocularis Dipeptidyl peptidase 9 0.015 0.1413 0.1412
Brugia malayi Dopamine receptor protein 2 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0233
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0068 0.0508 0.0764
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Leishmania major dihydroorotate dehydrogenase 0.0118 0.1062 0.1598
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0036 0.0161 0.0161
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0028 0.0072 0.0344
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0034 0.0146 0.0145
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0033 0.0032
Brugia malayi voltage-dependent calcium channel 0.0024 0.003 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0132 0.0132
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0571 0.5994 0.9029
Echinococcus granulosus geminin 0.0073 0.0567 0.0566
Onchocerca volvulus 0.0033 0.0132 0.0189
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0033 0.0033
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.003 0.0029
Schistosoma mansoni ryanodine receptor related 0.0024 0.003 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0033 0.0132 0.0132
Brugia malayi Zinc finger, C2H2 type family protein 0.0046 0.0275 0.0275
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0061 0.0432 0.0431
Echinococcus granulosus suppressor of cytokine signaling 6 0.0022 0.0007 0.0006
Trypanosoma brucei Peptide deformylase 2 0.0122 0.1099 0.1654
Echinococcus multilocularis 0.0022 0.0007 0.0006
Loa Loa (eye worm) voltage-gated potassium channel 0.0024 0.003 0.0029
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0024 0.003 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0034 0.0146 0.07
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Echinococcus multilocularis sodium channel protein 0.0398 0.411 0.411
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Schistosoma mansoni two-pore calcium channel 0.0024 0.003 0.003
Echinococcus multilocularis two pore calcium channel protein 2 0.0024 0.003 0.0029
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0067 0.0502 0.0501
Schistosoma mansoni tyrosine kinase 0.0061 0.0432 0.0432
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0132 0.0131
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Brugia malayi prolyl oligopeptidase family protein 0.0086 0.0714 0.0714
Trypanosoma brucei prolyl endopeptidase 0.0086 0.0714 0.1074
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0068 0.0508 0.0508
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0211 0.2076 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0068 0.0508 0.0508
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0033 0.0032
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0033 0.0033
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0022 0.0007 0.0006
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0132 0.0131
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0028 0.0072 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0034 0.0146 0.0146
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0046 0.0275 0.0274
Echinococcus multilocularis two pore calcium channel protein 1 0.0024 0.003 0.0029
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.003 0.0029
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0275 0.1322
Schistosoma mansoni biogenic amine (5HT) receptor 0.0033 0.0132 0.0132
Echinococcus multilocularis neuropeptide Y receptor 0.0033 0.0132 0.0131
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0024 0.003 0.003
Echinococcus multilocularis SH2 domain containing protein 7 0.0022 0.0007 0.0006
Onchocerca volvulus 0.004 0.0203 0.029
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.063 0.6639 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0024 0.003 0.003
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0033 0.0132 0.0131
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0024 0.003 0.003
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Brugia malayi Guanylate kinase family protein 0.0021 0.0001 0.0001
Schistosoma mansoni cell adhesion molecule 0.0025 0.004 0.004
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0502 0.0501
Echinococcus multilocularis sodium leak channel non selective protein 0.0024 0.003 0.0029
Echinococcus granulosus 7TM GPCR rhodopsin 0.0033 0.0132 0.0131
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0061 0.0432 0.0431
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Schistosoma mansoni apoptosis stimulating of P53 0.0021 0.0001 0.0001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0061 0.0432 0.0431
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0033 0.0032
Schistosoma mansoni dynamin-associated protein 0.0021 0.0001 0.0001
Echinococcus multilocularis SHC transforming protein 3 0.0022 0.0007 0.0006
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0024 0.003 0.003
Echinococcus multilocularis tyrosine protein kinase otk 0.0025 0.004 0.0039
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.003 0.0029
Onchocerca volvulus 0.0022 0.0007 0.0008
Schistosoma mansoni voltage-gated ion channel 0.0024 0.003 0.003
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0086 0.0714 0.0714
Schistosoma mansoni growth hormone secretagogue receptor 0.0033 0.0132 0.0132
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0211 0.2076 0.3126
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0046 0.0275 0.0413
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Brugia malayi steroid hormone receptor 0.0024 0.0033 0.0033
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0072 0.0344
Echinococcus multilocularis dro:myosuppressin receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis transient receptor potential gamma protein 0.0024 0.003 0.0029
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0702 0.7432 0.7432
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0022 0.0007 0.0006
Schistosoma mansoni tensin 0.0022 0.0007 0.0007
Brugia malayi hypoxia-induced factor 1 0.0065 0.0478 0.0478
Echinococcus granulosus peptide allatostatin:somatostatin 0.0033 0.0132 0.0131
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0024 0.003 0.0029
Echinococcus multilocularis mitogen activated protein kinase 11 0.063 0.6639 0.6638
Echinococcus granulosus tyrosine protein kinase shark 0.004 0.0203 0.0201
Echinococcus granulosus calcium activated potassium channel 0.0026 0.0056 0.0055
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0033 0.0032
Echinococcus granulosus acylamino acid releasing enzyme 0.0028 0.0072 0.0071
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0024 0.0033 0.0156
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0118 0.1062 0.1598
Schistosoma mansoni carbonic anhydrase 0.0189 0.1829 0.1829
Schistosoma mansoni family S28 unassigned peptidase (S28 family) 0.019 0.1841 0.1841
Schistosoma mansoni hypothetical protein 0.0022 0.0014 0.0014
Echinococcus granulosus neuropeptide receptor 0.0033 0.0132 0.0131
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Onchocerca volvulus 0.0033 0.0132 0.0189
Echinococcus granulosus fmrfamide receptor 0.0033 0.0132 0.0131
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0033 0.0132 0.0132
Echinococcus granulosus short transient receptor potential channel 6 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0024 0.003 0.0029
Echinococcus multilocularis ryanodine receptor 44f 0.0024 0.003 0.0029
Onchocerca volvulus 0.0033 0.0132 0.0189
Treponema pallidum polypeptide deformylase (def) 0.0319 0.325 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0033 0.0132 0.0132
Schistosoma mansoni neuropeptide F-like receptor 0.0033 0.0132 0.0132
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Echinococcus granulosus mitogen activated protein kinase 14 0.063 0.6639 0.6638
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0042 0.0234 0.0234
Leishmania major hypothetical protein, conserved 0.0024 0.003 0.0044
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0061 0.0432 0.0431
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0068 0.0508 0.2443
Onchocerca volvulus 0.0033 0.0132 0.0189
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0001 0.0001
Echinococcus multilocularis tyrosine protein kinase Abl 0.0061 0.0432 0.0431
Loa Loa (eye worm) TYRA-2 protein 0.0033 0.0132 0.0131
Echinococcus granulosus roundabout 2 0.0067 0.0502 0.0501
Echinococcus multilocularis SH2 motif 0.0022 0.0007 0.0006
Brugia malayi Fibronectin type III domain containing protein 0.0042 0.0234 0.0234
Toxoplasma gondii aminotransferase, putative 0.0304 0.3086 0.9489
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0047 0.0282 0.0424
Loa Loa (eye worm) hypothetical protein 0.0047 0.0285 0.0284
Echinococcus granulosus g protein coupled receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis neuropeptide receptor A26 0.0033 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0022 0.0007 0.0007
Echinococcus granulosus neuropeptide s receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0024 0.003 0.0029
Echinococcus multilocularis mitogen activated protein kinase 11 0.063 0.6639 0.6638
Brugia malayi Serotonin receptor 0.0627 0.6606 0.6606
Trypanosoma cruzi prolyl endopeptidase 0.0086 0.0714 0.1074
Schistosoma mansoni suppressor of cytokine signaling 0.0022 0.0007 0.0007
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.003 0.0029
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0024 0.003 0.003
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0024 0.003 0.0029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0132 0.0131
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0033 0.0132 0.0131
Schistosoma mansoni transient receptor potential channel 4 0.0024 0.003 0.003
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0211 0.2076 1
Echinococcus multilocularis somatostatin receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0046 0.0275 0.0274
Schistosoma mansoni neuroglian 0.0025 0.004 0.004
Echinococcus multilocularis prolyl endopeptidase 0.0086 0.0714 0.0713
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0033 0.0033
Echinococcus multilocularis potassium large conductance calcium activated 0.0024 0.003 0.0029
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0118 0.1062 0.1598
Onchocerca volvulus 0.004 0.0203 0.029
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0301 0.305 0.305
Schistosoma mansoni histamine h1 receptor 0.0033 0.0132 0.0132
Onchocerca volvulus 0.0033 0.0132 0.0189
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0236 0.0236
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0024 0.003 0.0139
Schistosoma mansoni alpha-1 adrenergic receptor 0.0033 0.0132 0.0132
Echinococcus granulosus tm gpcr rhodopsin 0.0033 0.0132 0.0131
Echinococcus multilocularis tyrosine protein kinase Srms 0.004 0.0203 0.0201
Echinococcus granulosus tyrosine protein kinase otk 0.0025 0.004 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.0033 0.0132 0.0131
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Schistosoma mansoni amine GPCR 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0036 0.0161 0.016
Leishmania major carbonic anhydrase family protein, putative 0.0189 0.1829 0.2753
Echinococcus granulosus tyrosine protein kinase Fyn 0.0061 0.0432 0.0431
Echinococcus multilocularis serotonin receptor 0.0033 0.0132 0.0131
Echinococcus granulosus tensin 0.0022 0.0007 0.0006
Schistosoma mansoni tyrosine kinase 0.004 0.0203 0.0203
Echinococcus multilocularis neuroglian 0.0053 0.0352 0.0351
Entamoeba histolytica SH2-protein kinase domain containing protein 0.004 0.0203 0.0971
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.015 0.1413 0.2127
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.015 0.1413 0.2127
Mycobacterium ulcerans peptide deformylase 0.0319 0.325 1
Echinococcus granulosus transient receptor potential gamma protein 0.0024 0.003 0.0029
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0068 0.0508 0.0764
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0034 0.0146 0.0145
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0033 0.0132 0.0132
Brugia malayi SH2 domain containing protein 0.004 0.0203 0.0203
Echinococcus multilocularis growth factor receptor bound protein 2 0.0043 0.0236 0.0235
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.003 0.0029
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0085 0.0085
Echinococcus multilocularis hemicentin 1 0.0025 0.004 0.0039
Echinococcus granulosus mitogen activated protein kinase 11 0.063 0.6639 0.6638
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.019 0.1841 0.184
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0033 0.0033
Echinococcus granulosus SHC transforming protein 3 0.0022 0.0007 0.0006
Schistosoma mansoni vav2 0.0023 0.0018 0.0018
Brugia malayi SRC-1 0.0061 0.0432 0.0432
Echinococcus granulosus hypothetical protein 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0033 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0033 0.0033
Schistosoma mansoni amine GPCR 0.0033 0.0132 0.0132
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0132 0.0131
Brugia malayi nuclear receptor NHR-88 0.0024 0.0033 0.0033
Echinococcus granulosus g protein coupled receptor 0.0033 0.0132 0.0131
Brugia malayi Protein kinase domain containing protein 0.004 0.0203 0.0203
Brugia malayi hypothetical protein 0.0022 0.0007 0.0007
Entamoeba histolytica carbonic anhydrase, putative 0.0189 0.1829 0.8808
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0034 0.0146 0.0145
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0033 0.0132 0.0131
Brugia malayi Tensin 0.0022 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0661 0.3182
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0024 0.003 0.0029
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0034 0.0146 0.0146
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Echinococcus multilocularis short transient receptor potential channel 6 0.0024 0.003 0.0029
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0938 1 1
Schistosoma mansoni GTPase activating protein 0.0022 0.0007 0.0007
Schistosoma mansoni cell adhesion molecule 0.0025 0.004 0.004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Brugia malayi P38 map kinase family protein 2 0.063 0.6639 0.6639
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0073 0.0567 0.0567
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.003 0.0029
Echinococcus granulosus neuropeptide FF receptor 2 0.0033 0.0132 0.0131
Echinococcus multilocularis Zinc finger, PHD finger 0.0034 0.0146 0.0145
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Schistosoma mansoni septate junction protein 0.0025 0.004 0.004
Brugia malayi olfactory channel protein osm-9 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus voltage gated hydrogen channel 1 0.0024 0.003 0.0029
Echinococcus granulosus voltage gated potassium channel 0.0024 0.003 0.0029
Echinococcus multilocularis sex peptide receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis g-protein coupled receptor 0.0033 0.0132 0.0131
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0033 0.0132 0.0132
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.003 0.0029
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0022 0.0007 0.0008
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0024 0.003 0.003
Schistosoma mansoni neuropeptide receptor 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0022 0.0013 0.0012
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0558 0.5861 0.5861
Brugia malayi hypothetical protein 0.0067 0.0503 0.0503
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0197 0.0197
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0043 0.0236 0.0235
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.003 0.0029
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0024 0.003 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0033 0.0033
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0046 0.0275 0.0274
Onchocerca volvulus 0.0033 0.0132 0.0189
Echinococcus multilocularis SH2 motif 0.0022 0.0007 0.0006
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0024 0.003 0.003
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0022 0.0007 0.0006
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.004 0.0203 0.0201
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.003 0.003
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0033 0.0033
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0024 0.003 0.0029
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0046 0.0275 0.1322
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis hyperpolarization activated cyclic 0.0024 0.003 0.0029
Loa Loa (eye worm) TK protein kinase 0.0029 0.0085 0.0084
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0033 0.0132 0.0132
Brugia malayi cytokine inducible SH2-containing protein 5 0.0022 0.0007 0.0007
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0132 0.0131
Schistosoma mansoni titin 0.0025 0.004 0.004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Loa Loa (eye worm) voltage-gated potassium channel 0.0024 0.003 0.0029
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0044 0.0043
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0118 0.1062 0.3113
Echinococcus multilocularis roundabout 2 0.0025 0.004 0.0039
Brugia malayi SH2 domain containing protein 0.004 0.0203 0.0203
Brugia malayi Variant SH3 domain containing protein 0.0022 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0033 0.0132 0.0132
Trypanosoma cruzi Peptide deformylase 2, putative 0.0122 0.1099 0.1654
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0033 0.0132 0.0131
Echinococcus granulosus voltage dependent calcium channel 0.0938 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0033 0.0032
Onchocerca volvulus 0.0033 0.0132 0.0189
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0067 0.0503 0.0502
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0508 0.2443
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Echinococcus granulosus SH2 domain containing adapter protein F 0.0022 0.0007 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0033 0.0132 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0033 0.0032
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0301 0.305 0.305
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Onchocerca volvulus 0.0033 0.0132 0.0189
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus neuropeptide receptor 0.0033 0.0132 0.0131
Schistosoma mansoni hypothetical protein 0.0033 0.0132 0.0132
Brugia malayi Myosin tail family protein 0.0021 0.0001 0.0001
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0024 0.003 0.003
Echinococcus multilocularis geminin 0.0073 0.0567 0.0566
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0122 0.1099 0.1654
Echinococcus granulosus hyperpolarization activated cyclic 0.0024 0.003 0.0029
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.003 0.0029
Brugia malayi Protein kinase domain containing protein 0.004 0.0203 0.0203
Brugia malayi Protein kinase domain containing protein 0.004 0.0203 0.0203
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0024 0.003 0.003
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0024 0.003 0.0029
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0061 0.0432 0.0431
Schistosoma mansoni transient receptor potential channel 0.0024 0.003 0.003
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0132 0.0131
Schistosoma mansoni SH2A 0.0022 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0033 0.0032
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0085 0.0701 0.3373
Brugia malayi GnHR receptor homolog 0.0033 0.0132 0.0132
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0024 0.003 0.0029
Loa Loa (eye worm) TK/ROR protein kinase 0.0029 0.0085 0.0084
Trypanosoma brucei prolyl oligopeptidase, putative 0.0047 0.0282 0.0424
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0558 0.5861 0.5861
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0236 0.0236
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus tyrosine protein kinase Srms 0.004 0.0203 0.0201
Schistosoma mansoni nck2/grb4 0.0043 0.0236 0.0236
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0024 0.003 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0132 0.0131
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0033 0.0132 0.0132
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Onchocerca volvulus 0.0023 0.0028 0.0038
Loa Loa (eye worm) G-protein coupled receptor 0.0033 0.0132 0.0131
Schistosoma mansoni cell adhesion molecule 0.0025 0.004 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.0033 0.0132 0.0131
Schistosoma mansoni Dab2-interacting protein-like 0.0021 0.0001 0.0001
Schistosoma mansoni transient receptor potential channel 0.0024 0.003 0.003
Echinococcus multilocularis neuropeptide FF receptor 2 0.0033 0.0132 0.0131
Brugia malayi Fes/CIP4 homology domain containing protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0022 0.0007 0.0006
Schistosoma mansoni run and tbc1 domain containing 0.0021 0.0001 0.0001
Echinococcus granulosus peroxidasin 0.0025 0.004 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0024 0.003 0.0029
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0022 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0024 0.003 0.003
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0043 0.0236 0.0236
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Onchocerca volvulus Neuropeptide F receptor homolog 0.0033 0.0132 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0033 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0072 0.0107
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0033 0.0032
Echinococcus granulosus alpha 1A adrenergic receptor 0.0033 0.0132 0.0131
Schistosoma mansoni tyrosine kinase 0.0061 0.0432 0.0432
Schistosoma mansoni tyrosine kinase 0.004 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Brugia malayi Dopamine receptor 0.0033 0.0132 0.0132
Brugia malayi protein-tyrosine kinase 0.004 0.0203 0.0203
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) SH2 domain-containing protein 0.0022 0.0007 0.0006
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.006 0.0423 0.0635
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0036 0.0161 0.016
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Brugia malayi hypothetical protein 0.004 0.0203 0.0203
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0024 0.003 0.003
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0024 0.003 0.0044
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0024 0.003 0.0029
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Schistosoma mansoni biogenic amine receptor 0.0033 0.0132 0.0132
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0033 0.0132 0.0132
Schistosoma mansoni tyrosine kinase 0.0043 0.0236 0.0236
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Echinococcus granulosus tyrosine protein kinase Src42A 0.0022 0.0007 0.0006
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0022 0.0007 0.0006
Brugia malayi Tachykinin-like peptides receptor 99D 0.0033 0.0132 0.0132
Brugia malayi Protein kinase domain containing protein 0.004 0.0203 0.0203
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0033 0.0033
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0118 0.1062 0.1598
Chlamydia trachomatis peptide deformylase 0.0319 0.325 0.5
Echinococcus granulosus roundabout 2 0.0025 0.004 0.0039
Onchocerca volvulus 0.0033 0.0132 0.0189
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0046 0.0275 0.1322
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0033 0.0033
Echinococcus granulosus contactin 0.0025 0.004 0.0039
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0029 0.0085 0.0084
Onchocerca volvulus 0.004 0.0203 0.029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0033 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Brugia malayi Protein kinase domain containing protein 0.004 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Schistosoma mansoni septate junction protein 0.0025 0.004 0.004
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0022 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0072 0.0071
Echinococcus multilocularis neuropeptide receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis tensin 0.0022 0.0007 0.0006
Echinococcus granulosus allatostatin A receptor 0.0033 0.0132 0.0131
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0068 0.0508 0.2443
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0033 0.0132 0.0131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Loa Loa (eye worm) prolyl oligopeptidase 0.0152 0.1433 0.1432
Brugia malayi cation channel family protein 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0152 0.1433 0.1432
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0095 0.0804 0.2402
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0034 0.0146 0.07
Onchocerca volvulus 0.0022 0.0007 0.0008
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0022 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase Blk 0.004 0.0203 0.0201
Schistosoma mansoni cell adhesion molecule 0.0056 0.0384 0.0384
Schistosoma mansoni tyrosine kinase 0.0061 0.0432 0.0432
Echinococcus granulosus Immunoglobulin 0.0042 0.0234 0.0233
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0938 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0033 0.0132 0.0131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0203 0.1991 0.959
Echinococcus multilocularis NCK adaptor protein 0.0043 0.0236 0.0235
Echinococcus granulosus G protein coupled receptor 139 0.0033 0.0132 0.0131
Onchocerca volvulus 0.0033 0.0132 0.0189
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0024 0.003 0.0029
Echinococcus granulosus tyrosine protein kinase Blk 0.004 0.0203 0.0201
Leishmania major polypeptide deformylase-like protein, putative 0.0122 0.1099 0.1654
Loa Loa (eye worm) hypothetical protein 0.0022 0.0007 0.0006
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0118 0.1062 0.2626
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.019 0.1841 0.184
Brugia malayi ion channel NompC 0.0024 0.003 0.003
Echinococcus granulosus sodium leak channel non selective protein 0.0024 0.003 0.0029
Schistosoma mansoni adapter molecule crk 0.0043 0.0236 0.0236
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0034 0.0146 0.0233
Echinococcus multilocularis potassium voltage gated channel protein 0.0024 0.003 0.0029
Brugia malayi putative neuropeptide receptor 0.0033 0.0132 0.0132
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.0236 0.0236
Schistosoma mansoni dreadlocks/dock 0.0021 0.0001 0.0001
Schistosoma mansoni neuropeptide receptor 0.0033 0.0132 0.0132
Schistosoma mansoni tensin 0.0022 0.0007 0.0007
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Brugia malayi Sex muscle abnormal protein 5 0.0043 0.0236 0.0236
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0118 0.1062 0.1062
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0024 0.003 0.003
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0118 0.1062 0.2626
Loa Loa (eye worm) neuropeptide F receptor 0.0033 0.0132 0.0131
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0047 0.0282 0.0424
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Echinococcus multilocularis signal transduction protein lnk realted 0.0022 0.0007 0.0006
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0024 0.003 0.0029
Schistosoma mansoni neuropeptide f receptor 76f 0.0033 0.0132 0.0132
Onchocerca volvulus 0.0033 0.0132 0.0189
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.063 0.6639 1
Brugia malayi Src substrate cortactin 0.0021 0.0001 0.0001
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0033 0.0132 0.0131
Onchocerca volvulus 0.0033 0.0132 0.0189
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0508 0.2443
Echinococcus granulosus potassium large conductance calcium activated 0.0024 0.003 0.0029
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0033 0.0033
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0059 0.0413 0.0441
Echinococcus granulosus potassium voltage gated channel protein 0.0024 0.003 0.0029
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0122 0.1099 0.1654
Schistosoma mansoni sorbin 0.0021 0.0001 0.0001
Loa Loa (eye worm) TK/ABL protein kinase 0.004 0.0203 0.0201
Schistosoma mansoni vesicular amine transporter 0.0066 0.0492 0.0492
Echinococcus multilocularis fmrfamide receptor 0.0033 0.0132 0.0131
Echinococcus granulosus NCK adaptor protein 0.0043 0.0236 0.0235
Echinococcus granulosus neuroglian 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Loa Loa (eye worm) SRC-1 0.0061 0.0432 0.0431
Plasmodium falciparum peptide deformylase 0.0319 0.325 1
Loa Loa (eye worm) ion channel NompC 0.0024 0.003 0.0029
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0127 0.116 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0061 0.0432 0.0431
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0024 0.003 0.0029
Brugia malayi hypothetical protein 0.0033 0.0132 0.0132
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0024 0.003 0.003
Echinococcus multilocularis peroxidasin 0.0025 0.004 0.0039
Echinococcus granulosus serotonin receptor 0.0033 0.0132 0.0131
Brugia malayi G-protein coupled receptor 0.0033 0.0132 0.0132
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0024 0.003 0.003
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0938 1 1
Onchocerca volvulus 0.0022 0.0007 0.0008
Echinococcus multilocularis roundabout 2 0.0067 0.0502 0.0501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0267 0.2689 0.2688
Brugia malayi Peripheral plasma membrane protein CASK 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus tyrosine protein kinase Fps85D 0.004 0.0203 0.0201
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0189 0.1829 0.521
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0047 0.0282 0.0424
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0132 0.1212 0.1211
Brugia malayi hypothetical protein 0.0042 0.0234 0.0234
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0033 0.0132 0.0131
Loa Loa (eye worm) SH2 domain-containing protein 0.0022 0.0007 0.0006
Schistosoma mansoni voltage-gated potassium channel 0.0024 0.003 0.003
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0024 0.003 0.003
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0025 0.004 0.0039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0384 0.0383
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0034 0.0146 0.0219
Echinococcus multilocularis tyrosine protein kinase shark 0.004 0.0203 0.0201
Entamoeba histolytica prolyl oligopeptidase family protein 0.0028 0.0072 0.0344
Brugia malayi G-protein coupled receptor 0.0033 0.0132 0.0132
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0118 0.1062 0.2626
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0319 0.325 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0118 0.1062 0.1062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Trypanosoma cruzi Peptide deformylase 2, putative 0.0122 0.1099 0.1654
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0033 0.0132 0.0131
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0033 0.0132 0.0131
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0034 0.0146 0.0361
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0211 0.2076 1
Echinococcus granulosus transient receptor potential cation channel 0.0024 0.003 0.0029
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0022 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0073 0.0567 0.0567
Onchocerca volvulus 0.0022 0.0007 0.0008
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0024 0.003 0.0029
Echinococcus multilocularis hemicentin 1 0.0025 0.004 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0033 0.0033
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0028 0.0072 0.0107
Onchocerca volvulus 0.0033 0.0132 0.0189
Brugia malayi Prion-like- 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Entamoeba histolytica hypothetical protein 0.0022 0.0013 0.0056
Toxoplasma gondii prolyl endopeptidase 0.0086 0.0714 0.2124
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Entamoeba histolytica hypothetical protein 0.0178 0.1714 0.8257
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0024 0.003 0.003
Plasmodium vivax peptide deformylase, putative 0.0319 0.325 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0234 0.0234
Echinococcus granulosus short transient receptor potential channel 6 0.0024 0.003 0.0029
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0033 0.0132 0.0132
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0036 0.0161 0.0161
Echinococcus granulosus voltage dependent calcium channel 0.0196 0.1913 0.1912
Trypanosoma brucei Polypeptide deformylase 1 0.0122 0.1099 0.1654
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.016 0.1521 0.7328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0022 0.0007 0.0006
Mycobacterium ulcerans carbonic anhydrase 0.0082 0.0661 0.1277
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0033 0.0032
Schistosoma mansoni hypothetical protein 0.0033 0.0132 0.0132
Brugia malayi SH2 domain containing protein 0.0022 0.0007 0.0007
Brugia malayi Serotonin receptor 0.0033 0.0132 0.0132
Echinococcus granulosus rhodopsin orphan GPCR 0.0033 0.0132 0.0131
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0086 0.0714 0.0714
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0033 0.0132 0.0189
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0301 0.305 0.305
Echinococcus multilocularis serotonin receptor 0.0033 0.0132 0.0131
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0021 0.0001 0.0001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0033 0.0132 0.0132
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0025 0.004 0.0039
Echinococcus multilocularis c src tyrosine kinase 0.0061 0.0432 0.0431
Onchocerca volvulus 0.0033 0.0132 0.0189
Brugia malayi Melatonin receptor type 1A 0.0033 0.0132 0.0132
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0033 0.0033
Echinococcus granulosus voltage gated potassium channel 0.0024 0.003 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0033 0.0033
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Echinococcus multilocularis voltage gated potassium channel 0.0024 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0032
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0118 0.1062 0.1598
Echinococcus multilocularis mitogen activated protein kinase 14 0.063 0.6639 0.6638
Echinococcus multilocularis voltage dependent calcium channel 0.0938 1 1
Schistosoma mansoni hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0042 0.0234 0.0233
Echinococcus multilocularis G protein coupled receptor 139 0.0033 0.0132 0.0131
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Onchocerca volvulus 0.0033 0.0132 0.0189
Schistosoma mansoni hypothetical protein 0.0021 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0033 0.0032
Echinococcus multilocularis lachesin 0.0025 0.004 0.0039
Schistosoma mansoni nephrin 0.0025 0.004 0.004
Loa Loa (eye worm) voltage-gated calcium channel 0.0024 0.003 0.0029
Onchocerca volvulus 0.0022 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Echinococcus granulosus SH2 motif 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0203 0.0201
Loa Loa (eye worm) hypoxia-induced factor 1 0.0065 0.0478 0.0477
Echinococcus granulosus 7tm_1 domain containing protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) TK protein kinase 0.004 0.0203 0.0201
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0107 0.0939 0.2213
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) TK/FER protein kinase 0.004 0.0203 0.0201
Brugia malayi prolyl oligopeptidase family protein 0.0028 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0033 0.0033
Echinococcus granulosus neuropeptides capa receptor 0.0033 0.0132 0.0131
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0024 0.003 0.0029
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0061 0.0432 0.0431
Brugia malayi Variant SH3 domain containing protein 0.0021 0.0001 0.0001
Echinococcus granulosus hypothetical protein 0.0024 0.003 0.0029
Echinococcus granulosus somatostatin receptor 0.0033 0.0132 0.0131
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0028 0.0072 0.0344
Echinococcus multilocularis Immunoglobulin 0.0042 0.0234 0.0233
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0061 0.0432 0.0431
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0022 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0033 0.0132 0.0131
Loa Loa (eye worm) hypothetical protein 0.0024 0.003 0.0029
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0024 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0039
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0024 0.003 0.0029
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0211 0.2076 0.3126
Loa Loa (eye worm) hypothetical protein 0.0086 0.0714 0.0713
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0034 0.0146 0.0145
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0033 0.0033

Activities

Activity type Activity value Assay description Source Reference
Ataxia (ADMET) = 100 % Percentage toxicity measured as ataxia. ChEMBL. 7205874
Ataxia (ADMET) = 100 % Percentage toxicity measured as ataxia. ChEMBL. 7205874
Convulsion (ADMET) = 0 % Percentage toxicity measured as convulsions. ChEMBL. 7205874
Convulsion (ADMET) = 0 % Percentage toxicity measured as convulsions. ChEMBL. 7205874
Death (ADMET) = 0 % Percentage toxicity measured as death of mice. ChEMBL. 7205874
Death (ADMET) = 0 % Percentage toxicity measured as death of mice. ChEMBL. 7205874
ED50 (functional) = 0.18 mM kg-1 Protection against choloroform induced arrhythmias was measured in mice after sc administration at given dose ChEMBL. 7205874
ED50 (functional) = 0.18 mM kg-1 Ataxia was measured in mice after sc administration at given dose ChEMBL. 7205874
ED50 (functional) = 0.18 mM kg-1 Protection against choloroform induced arrhythmias was measured in mice after sc administration at given dose ChEMBL. 7205874
ED50 (functional) = 0.18 mM kg-1 Ataxia was measured in mice after sc administration at given dose ChEMBL. 7205874
Loss of righting reflex (ADMET) = 0 % Percentage toxicity measured as loss of righting reflex. ChEMBL. 7205874
Loss of righting reflex (ADMET) = 0 % Percentage toxicity measured as loss of righting reflex. ChEMBL. 7205874
Protection (functional) = 90 % Protection against choloroform induced arrhythmias in mice after subcutaneous administration at 100 mg/kg dose. ChEMBL. 7205874
Protection (functional) = 90 % Protection against choloroform induced arrhythmias in mice after subcutaneous administration at 100 mg/kg dose. ChEMBL. 7205874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.