Detailed information for compound 262710

Basic information

Technical information
  • TDR Targets ID: 262710
  • Name: 2-benzyl-7-methylbenzo[d][1,3,2]dithiazole 1- oxide
  • MW: 275.389 | Formula: C14H13NOS2
  • H donors: 0 H acceptors: 1 LogP: 4.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc2c1[S+]([O-])N(S2)Cc1ccccc1
  • InChi: 1S/C14H13NOS2/c1-11-6-5-9-13-14(11)18(16)15(17-13)10-12-7-3-2-4-8-12/h2-9H,10H2,1H3
  • InChiKey: WLASPUHKIKVYQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-benzyl-7-methyl-benzo[d][1,3,2]dithiazole 1-oxide
  • 7-methyl-2-(phenylmethyl)benzo[d][1,3,2]dithiazole 1-oxide
  • 2-(benzyl)-7-methyl-benzo[d][1,3,2]dithiazole 1-oxide
  • 6-Methyl-2-benzylbenzo[d]1,3,2-dithiazoline, 1-oxide
  • AIDS-029640
  • AIDS029640

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum fructose-bisphosphate aldolase 0.063 0.4185 0.6899
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0437 0.1004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Echinococcus multilocularis pyruvate kinase 0.0018 0.0038 0.003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0012
Brugia malayi chromobox protein homolog 3 0.0042 0.0198 0.1386
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.005 0.0446
Brugia malayi 6-phosphofructokinase 0.0117 0.0705 0.493
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0735 0.4902 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.005 0.0446
Echinococcus multilocularis musashi 0.0029 0.011 0.0102
Brugia malayi glutathione reductase 0.0051 0.0257 0.1798
Mycobacterium ulcerans hypothetical protein 0.0022 0.006 0.0083
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0102 0.0126
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0033 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0437 0.6097
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0057 0.0836
Echinococcus multilocularis lamin dm0 0.0029 0.011 0.0102
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0033 0.0296
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0142 0.1785
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0437 0.6097
Toxoplasma gondii ABC1 family protein 0.0077 0.0437 0.9204
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0171 0.1074 0.3009
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0705 0.0698
Loa Loa (eye worm) sugar transporter 0.0016 0.0019 0.0109
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.005 0.003
Loa Loa (eye worm) sugar transporter 0.0016 0.0019 0.0109
Brugia malayi beta-lactamase family protein 0.0077 0.0437 0.3058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.005 0.0063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0437 0.0858
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0437 0.1004
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0705 0.4916
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0151 0.0245
Trypanosoma brucei DNA polymerase eta, putative 0.0085 0.0487 0.6827
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0213 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0106 0.0716
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0396 0.5488
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0142 0.2695
Leishmania major DNA polymerase eta, putative 0.0085 0.0487 0.6827
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0705 0.4916
Echinococcus granulosus geminin 0.0347 0.2266 0.226
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0705 0.2024
Trichomonas vaginalis conserved hypothetical protein 0.0518 0.343 0.8188
Trichomonas vaginalis rotamase, putative 0.0035 0.0151 0.0316
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0117 0.0705 0.1914
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0705 0.1408
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0126 0.0194
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0126 0.0257
Giardia lamblia Fructose-bisphosphate aldolase 0.063 0.4185 1
Echinococcus multilocularis pyruvate kinase 0.0036 0.0157 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Trypanosoma brucei unspecified product 0.004 0.018 0.2346
Loa Loa (eye worm) hypothetical protein 0.0077 0.0437 0.3039
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0705 0.1646
Toxoplasma gondii endonuclease IV APN 0.0083 0.0474 1
Leishmania major basic transcription factor 3a, putative 0.0034 0.0142 0.1785
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0142 0.2695
Brugia malayi ImpB/MucB/SamB family protein 0.0085 0.0487 0.3408
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Brugia malayi Thioredoxin reductase 0.0051 0.0257 0.1798
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0257 0.1775
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.107
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0422 0.0968
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0019 0.0012
Echinococcus granulosus chromobox protein 1 0.0075 0.0422 0.0415
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0437 0.112
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0038 0.0401
Mycobacterium ulcerans epimerase 0.0022 0.006 0.0083
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0437 0.9204
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0012
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0515 0.3407 1
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0705 0.1584
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0157 0.2
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0157 0.3019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0018 0.0099
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0032 0.0222
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0332 0.0643
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0032 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.0699 0.2006
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0057 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0033 0.0196
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0332 0.0643
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0437 0.1234
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.011 0.0767
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0032 0.018
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0396 0.5488
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0126 0.0257
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0437 0.1004
Leishmania major trypanothione reductase 0.0051 0.0257 0.3467
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.005 0.009
Echinococcus multilocularis pyruvate kinase 0.0018 0.0038 0.003
Echinococcus multilocularis neuropeptide receptor A26 0.0502 0.3317 0.3311
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0198 0.0429
Schistosoma mansoni lamin 0.0029 0.011 0.0091
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0184 0.1158 0.3258
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0126 0.0257
Schistosoma mansoni DNA polymerase eta 0.0085 0.0487 0.0469
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0122 0.0114
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.0787 0.2157
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0057 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0032 0.018
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0471 0.311 0.9049
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.005 0.0673
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0057 0.0401
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0019 0.0109
Treponema pallidum penicillin-binding protein (pbp-1) 0.0735 0.4902 0.8091
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0032 0.003
Treponema pallidum penicillin-binding protein (pbp-3) 0.0905 0.6051 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0301 0.0282
Trichomonas vaginalis ap endonuclease, putative 0.002 0.005 0.0073
Loa Loa (eye worm) hypothetical protein 0.0083 0.0474 0.3293
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0151 0.1921
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Schistosoma mansoni ap endonuclease 0.002 0.005 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.0111
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.0111
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0518 0.343 0.7003
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0157 0.0329
Mycobacterium ulcerans DNA polymerase IV 0.0086 0.0496 0.0978
Trichomonas vaginalis ap endonuclease, putative 0.002 0.005 0.0073
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0705 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0437 0.3039
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0515 0.3407 0.9932
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.0787 0.2265
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0024
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0126 0.0257
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0102 0.0095
Echinococcus multilocularis pyruvate kinase 0.0036 0.0157 0.0149
Echinococcus granulosus dna polymerase kappa 0.0086 0.0496 0.0489
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0102 0.1822
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0157 0.107
Chlamydia trachomatis pyruvate kinase 0.0036 0.0157 0.0256
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0126 0.0257
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.0111
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0102 0.1822
Schistosoma mansoni lamin 0.0029 0.011 0.0091
Schistosoma mansoni pyruvate kinase 0.0036 0.0157 0.0137
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0301 0.2082
Trypanosoma brucei DNA polymerase kappa, putative 0.0064 0.0349 0.481
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0019 0.0012
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0033 0.0196
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0025 0.0081 0.136
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0705 0.1119
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0012
Schistosoma mansoni intermediate filament proteins 0.0029 0.011 0.0091
Echinococcus granulosus flap endonuclease 1 0.0028 0.0102 0.0095
Loa Loa (eye worm) hypothetical protein 0.0033 0.0136 0.0929
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0012
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0308 0.1999 0.4065
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0495 0.3268 0.9588
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0057 0.0836
Plasmodium falciparum glutathione reductase 0.0018 0.0032 0.0272
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0301 0.0282
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0032 0.018
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0083 0.0474 0.1228
Mycobacterium tuberculosis Probable reductase 0.0116 0.0699 0.2006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.0699 0.2006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Loa Loa (eye worm) glutathione reductase 0.0051 0.0257 0.1775
Loa Loa (eye worm) hypothetical protein 0.0077 0.0437 0.3039
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0126 0.0157
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0301 0.2104
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Echinococcus granulosus expressed protein 0.0036 0.0157 0.0149
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0057 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0375
Schistosoma mansoni microtubule-associated protein tau 0.1487 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.143 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.011 0.0742
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0032 0.0272
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0057 0.0554
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0705 0.0687
Plasmodium falciparum pyruvate kinase 0.0036 0.0157 0.3019
Loa Loa (eye worm) hypothetical protein 0.0042 0.0198 0.1362
Brugia malayi intermediate filament protein 0.0029 0.011 0.0767
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0126 0.2356
Echinococcus multilocularis transcription factor btf3 0.0034 0.0142 0.0134
Schistosoma mansoni rotamase 0.0036 0.0157 0.0138
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Loa Loa (eye worm) hypothetical protein 0.0085 0.0487 0.339
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0308 0.1999 0.5844
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0198 0.1104
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0033 0.0196
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.063 0.4185 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0038 0.0018
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0033 0.0296
Echinococcus multilocularis expressed protein 0.0036 0.0157 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0151 0.1921
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0437 0.1234
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0219 0.2917
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0332 0.4565
Brugia malayi 6-phosphofructokinase 0.0117 0.0705 0.493
Echinococcus multilocularis geminin 0.0347 0.2266 0.226
Brugia malayi phosphofructokinase 0.0117 0.0705 0.493
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Trichomonas vaginalis esterase, putative 0.0077 0.0437 0.1004
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0229 0.3051
Loa Loa (eye worm) hypothetical protein 0.0077 0.0437 0.3039
Echinococcus multilocularis pyruvate kinase 0.0018 0.0038 0.003
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0115 0.0229
Onchocerca volvulus 0.0077 0.0437 0.258
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0102 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0364 0.2386 0.6901
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0126 0.2356
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0019 0.0012
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0083 0.0474 0.3311
Echinococcus multilocularis chromobox protein 1 0.0075 0.0422 0.0415
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0033 0.0196
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0157 0.2
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0332 0.0325
Schistosoma mansoni hypothetical protein 0.0347 0.2266 0.2251
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0157 0.107
Plasmodium falciparum glutathione reductase 0.0051 0.0257 0.5234
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0705 1
Mycobacterium leprae Probable lipase LipE 0.0077 0.0437 0.112
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0033 0.0196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.0699 0.2006
Trypanosoma brucei DNA polymerase IV, putative 0.0086 0.0496 0.6946
Echinococcus multilocularis lamin 0.0029 0.011 0.0102
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0257 0.025
Echinococcus multilocularis pyruvate kinase 0.0028 0.0105 0.0098
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0437 0.1234
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0142 0.0967
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0157 0.0846
Leishmania major DNA polymerase eta, putative 0.0045 0.0219 0.2917
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0038 0.0401
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0518 0.343 1
Onchocerca volvulus 0.0029 0.011 0.0557
Trichomonas vaginalis set domain proteins, putative 0.0255 0.164 0.3891
Brugia malayi major facilitator superfamily protein 0.0016 0.0019 0.0136
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0018 0.0126
Echinococcus multilocularis microtubule associated protein 2 0.1487 1 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0083 0.0552
Loa Loa (eye worm) heterochromatin protein 1 0.0075 0.0422 0.2935
Schistosoma mansoni DNA helicase recq1 0.0021 0.0057 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0705 0.1646
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0032 0.0272
Entamoeba histolytica hypothetical protein 0.0034 0.0142 0.0222
Echinococcus granulosus neuropeptide s receptor 0.0502 0.3317 0.3311
Mycobacterium ulcerans hypothetical protein 0.0018 0.0033 0.0028
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0301 0.0607
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0734 0.489 1
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0012
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0157 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0229 0.3051
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0157 0.0287
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0396 0.0388
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0032 0.018
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0474 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0301 0.0831
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0151 0.1921
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0057 0.0091
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0332 0.0314
Onchocerca volvulus 0.0033 0.0136 0.0722
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0229 0.3051
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0396 0.5488
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.006 0.0083
Leishmania major pyruvate kinase 0.0036 0.0157 0.2
Trypanosoma cruzi DNA polymerase eta, putative 0.0085 0.0487 0.6827
Plasmodium vivax SET domain protein, putative 0.0032 0.013 0.2434
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0437 0.1234
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0126 0.0257
Echinococcus granulosus neuropeptide receptor A26 0.0502 0.3317 0.3311
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0057 0.0836
Mycobacterium ulcerans hypothetical protein 0.0077 0.0437 0.0858
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0437 0.043
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0437 0.1004
Brugia malayi major facilitator superfamily protein 0.0016 0.0019 0.0136
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.005 0.0349
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0157 0.1097
Brugia malayi beta-lactamase 0.0077 0.0437 0.3058
Echinococcus multilocularis neuropeptide s receptor 0.0502 0.3317 0.3311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0396 0.0388
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0126 0.2356
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0057 0.005
Chlamydia trachomatis endonuclease IV 0.0083 0.0474 0.0907
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0057 0.0375
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0057 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0086 0.0496 0.6946
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0102 0.0199
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0126 0.2356
Brugia malayi Flap endonuclease-1 0.0028 0.0102 0.0714
Plasmodium falciparum flap endonuclease 1 0.0028 0.0102 0.1822
Brugia malayi beta-NAC-like protein 0.0034 0.0142 0.0991
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Trichomonas vaginalis chromobox protein, putative 0.0045 0.022 0.0482
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0184 0.1158 0.3361
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0032 0.0025
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0142 0.1785
Loa Loa (eye worm) hypothetical protein 0.0022 0.006 0.0392
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0102 0.0199
Echinococcus granulosus pyruvate kinase 0.0036 0.0157 0.0149
Plasmodium falciparum thioredoxin reductase 0.0051 0.0257 0.5234
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0157 0.107
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0705 0.0687
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0032 0.0036
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0157 0.0282
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0083 0.0474 1
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0257 0.3467
Echinococcus granulosus dna polymerase eta 0.0085 0.0487 0.048
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0364 0.2386 0.4858
Brugia malayi SET domain containing protein 0.0013 0.0004 0.0026
Trichomonas vaginalis DNA polymerase eta, putative 0.0086 0.0496 0.1143
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0705 0.1646
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0175 0.1097 0.3179
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0471 0.311 0.6345
Loa Loa (eye worm) hypothetical protein 0.0025 0.0083 0.0552
Mycobacterium ulcerans endonuclease IV 0.0083 0.0474 0.0933
Leishmania major DNA damage repair protein, putative 0.0018 0.0033 0.0196
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0157 0.0405
Echinococcus granulosus chromobox protein 1 0.0075 0.0422 0.0415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Leishmania major hypothetical protein, conserved 0.0077 0.0437 0.6097
Loa Loa (eye worm) hypothetical protein 0.0046 0.0228 0.1568
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0294
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0396 0.2747
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0057 0.005
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.006 0.025
Giardia lamblia Pyruvate kinase 0.0018 0.0038 0.0044
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0126 0.0185
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.022 0.1238
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.005 0.0042
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0057 0.0091
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0057 0.0554
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0192 0.0185
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0742
Schistosoma mansoni pyruvate kinase 0.0036 0.0157 0.0137
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0032 0.0272
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.005 0.0042
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0705 0.1584
Schistosoma mansoni ap endonuclease 0.002 0.005 0.0031
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0016 0.0019 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0437 0.0419
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0157 0.2
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0228 0.3037
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0515 0.3407 0.6956
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0219 0.4404
Giardia lamblia DNA damage repair protein 0.0018 0.0033 0.0032
Mycobacterium tuberculosis Conserved protein 0.0077 0.0437 0.1234
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0705 0.1646
Onchocerca volvulus 0.0077 0.0437 0.258
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.005 0.0446
Giardia lamblia Pyruvate kinase 0.0036 0.0157 0.0329
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0304 0.2104
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0115 0.0229
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0705 0.1584
Trypanosoma brucei unspecified product 0.004 0.018 0.2346
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.006 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0437 0.1004
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0308 0.1999 0.5755
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0032 0.0024
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0142 0.0222
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0171 0.1074 0.3112
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0437 0.1234
Leishmania major pyruvate kinase 0.0036 0.0157 0.2
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.005 0.0323
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0437 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0157 0.033
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Toxoplasma gondii thioredoxin reductase 0.0051 0.0257 0.5234
Onchocerca volvulus 0.0029 0.011 0.0557
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0157 0.3019
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0126 0.0257
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0032 0.0272
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0057 0.005
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0057 0.0401
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.013 0.2434
Brugia malayi beta-lactamase family protein 0.0077 0.0437 0.3058
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0126 0.0194
Toxoplasma gondii exonuclease III APE 0.002 0.005 0.0673
Chlamydia trachomatis transglycolase/transpeptidase 0.0363 0.2373 0.4807
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.013 0.0123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0151 0.1921
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0198 0.0429
Brugia malayi Pre-SET motif family protein 0.0032 0.013 0.0909
Mycobacterium tuberculosis Conserved protein 0.0077 0.0437 0.1234
Loa Loa (eye worm) beta-lactamase 0.0077 0.0437 0.3039
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0102 0.1207
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Leishmania major DNA polymerase kappa, putative 0.0064 0.0349 0.481
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0019 0.0012
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0437 0.3058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0032 0.018
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0332 0.0325
Trichomonas vaginalis chromobox protein, putative 0.0045 0.022 0.0482
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.0787 0.2265
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0471 0.311 0.9121
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0064 0.0349 0.0974
Echinococcus granulosus Solute carrier family 22 5 0.1113 0.7463 0.7461
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0157 0.0329
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0151 0.2899
Plasmodium vivax glutathione reductase, putative 0.0051 0.0257 0.5234
Brugia malayi Pre-SET motif family protein 0.0224 0.143 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0157 0.0846
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0364 0.2386 0.6984
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0157 0.2
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0116 0.0699 0.1896
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0057 0.005
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0142 0.2695
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0126 0.2356
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0301 0.0294
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0019 0.0109
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0033 0.0296
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0033 0.0196
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Echinococcus multilocularis dna polymerase kappa 0.0086 0.0496 0.0489
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0057 0.0554
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0126 0.2356
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0032 0.0025
Echinococcus granulosus bloom syndrome protein 0.0021 0.0057 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0032 0.018
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0033 0.0196
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0064 0.0349 0.481
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0102 0.0689
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0057 0.0091
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0126 0.0257
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.063 0.4185 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0705 0.4916
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0032 0.0272
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0437 0.0419
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.0077 0.0437 0.3039
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0157 0.1094
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0012
Schistosoma mansoni DNA helicase recq5 0.0021 0.0057 0.0038
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.0699 0.2006
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0012
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0257 0.025
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0142 0.1785
Chlamydia trachomatis transglycolase/transpeptidase 0.0735 0.4902 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.013 0.0123
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0396 0.0377
Trichomonas vaginalis chromobox protein, putative 0.0075 0.0422 0.0968
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0705 0.0698
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0038 0.0401
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0157 0.1072
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0033 0.0196
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.0787 0.2265
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0437 0.043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0109
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.005 0.0063
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0437 0.0858
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0086 0.0496 0.1143
Onchocerca volvulus 0.0077 0.0437 0.258
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0032 0.018
Schistosoma mansoni transcription factor btf3 0.0034 0.0142 0.0123
Brugia malayi Heterochromatin protein 1 0.0075 0.0422 0.2954
Treponema pallidum hypothetical protein 0.0171 0.1074 0.1731
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0171 0.1074 0.2165
Echinococcus granulosus lamin dm0 0.0029 0.011 0.0102
Echinococcus multilocularis dna polymerase eta 0.0085 0.0487 0.048
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0257 0.0702
Brugia malayi polk-prov protein 0.0046 0.0228 0.1591
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0884
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0332 0.0924
Schistosoma mansoni chromobox protein 0.0075 0.0422 0.0404
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.005 0.0446
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0032 0.018
Treponema pallidum penicillin-binding protein (pbp-2) 0.0518 0.343 0.5646
Echinococcus granulosus lamin 0.0029 0.011 0.0102
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0437 0.1234
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0705 1
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0032 0.018
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0437 0.6097
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0228 0.3037
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0257 0.5234
Plasmodium falciparum thioredoxin reductase 0.0018 0.0032 0.0272
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0033 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0057 0.0836
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Mycobacterium ulcerans beta-lactamase 0.0077 0.0437 0.0858
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Echinococcus granulosus intermediate filament protein 0.0029 0.011 0.0102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.011 0.0742
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0032 0.0025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.063 0.4185 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0032 0.018
Loa Loa (eye worm) RecQ helicase 0.0021 0.0057 0.0375
Schistosoma mansoni chromobox protein 0.0075 0.0422 0.0404
Echinococcus multilocularis chromobox protein 1 0.0075 0.0422 0.0415
Echinococcus granulosus transcription factor btf3 0.0034 0.0142 0.0134
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0102 0.1207
Schistosoma mansoni flap endonuclease-1 0.0025 0.0084 0.0065
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.005 0.0673
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0032 0.0272
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0396 0.2767
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Mycobacterium tuberculosis Conserved protein 0.0077 0.0437 0.1234
Leishmania major DNA polymerase kappa, putative 0.0018 0.0033 0.0196
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0437 0.3039
Onchocerca volvulus 0.0044 0.0213 0.1198
Trypanosoma brucei trypanothione reductase 0.0051 0.0257 0.3467
Giardia lamblia DINP protein human, muc B family 0.0064 0.0349 0.0792
Echinococcus granulosus pyruvate kinase 0.0018 0.0038 0.003
Trypanosoma brucei unspecified product 0.0079 0.0447 0.6241
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0192 0.0185
Mycobacterium ulcerans DNA polymerase IV 0.0086 0.0496 0.0978
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.006 0.0418
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0012
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0332 0.2324
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0301 0.0294
Mycobacterium ulcerans lipase LipD 0.0077 0.0437 0.0858
Onchocerca volvulus 0.0255 0.164 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0396 0.5488
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0083 0.0474 0.1341
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0083 0.0079
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0447 0.6241
Echinococcus granulosus pyruvate kinase 0.0036 0.0157 0.0149
Loa Loa (eye worm) hypothetical protein 0.0077 0.0437 0.3039
Echinococcus granulosus pyruvate kinase 0.0018 0.0038 0.003
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0126 0.2356
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.0699 0.2006
Schistosoma mansoni hypothetical protein 0.0347 0.2266 0.2251
Trichomonas vaginalis rotamase, putative 0.0036 0.0157 0.033
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.005 0.0073
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0396 0.0836
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0142 0.0294
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0157 0.1094
Trypanosoma cruzi DNA polymerase kappa, putative 0.0086 0.0496 0.6946
Echinococcus granulosus pyruvate kinase 0.0018 0.0038 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.013 0.0123
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0032 0.003

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.78 ug ml-1 Antifungal activity against Candida albicans 10231 strain ChEMBL. 8126696
MIC (functional) = 0.78 ug ml-1 Antifungal activity against Candida albicans 579A strain ChEMBL. 8126696
MIC (functional) = 0.78 ug ml-1 Antifungal activity against Candida albicans 10231 strain ChEMBL. 8126696
MIC (functional) = 0.78 ug ml-1 Antifungal activity against Candida albicans 579A strain ChEMBL. 8126696
MIC (functional) = 1.56 ug ml-1 Antifungal activity against Candida albicans CCH442 strain ChEMBL. 8126696
MIC (functional) = 1.56 ug ml-1 Antifungal activity against Candida albicans 38247 strain ChEMBL. 8126696
MIC (functional) = 1.56 ug ml-1 Antifungal activity against Candida albicans CCH442 strain ChEMBL. 8126696
MIC (functional) = 1.56 ug ml-1 Antifungal activity against Candida albicans 38247 strain ChEMBL. 8126696

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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