Detailed information for compound 268887

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 282.292 | Formula: C13H18N2O5
  • H donors: 3 H acceptors: 5 LogP: -1.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C[C@@H](C[C@H](Cc1ccncc1C(=O)N)O)O
  • InChi: 1S/C13H18N2O5/c1-20-12(18)6-10(17)5-9(16)4-8-2-3-15-7-11(8)13(14)19/h2-3,7,9-10,16-17H,4-6H2,1H3,(H2,14,19)/t9-,10+/m0/s1
  • InChiKey: JFMMZMAJZFZTEK-VHSXEESVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0092 0.0539
Loa Loa (eye worm) hypothetical protein 0.0019 0.0042 0.0057
Onchocerca volvulus 0.0136 0.1072 0.1457
Echinococcus multilocularis voltage gated potassium channel subunit 0.002 0.0056 0.0076
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0225 0.0306
Entamoeba histolytica hypothetical protein 0.0037 0.0204 0.0559
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0639
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.2698 1
Plasmodium falciparum aldehyde reductase, putative 0.002 0.0056 0.0523
Echinococcus granulosus GPCR family 2 0.0017 0.0025 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0117 0.2357
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.0092 0.1484
Echinococcus multilocularis notch 0.0136 0.1072 0.1457
Loa Loa (eye worm) hypothetical protein 0.0017 0.0025 0.0034
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0132 0.0467
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0025 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0047 0.0173
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.2698 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.0398
Echinococcus granulosus aldo keto reductase 0.0045 0.0276 0.0276
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0025 0.0034
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0489 0.0665
Onchocerca volvulus 0.0136 0.1072 0.1457
Brugia malayi hypothetical protein 0.0029 0.0132 0.0145
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0991 0.1347
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0132 0.0571
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0276 0.0342
Echinococcus granulosus peroxidasin 0.0849 0.7358 0.7358
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Plasmodium falciparum aldo-keto reductase, putative 0.002 0.0056 0.0523
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0045 0.0276 0.2201
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Brugia malayi Calcium binding EGF domain containing protein 0.0136 0.1072 0.1428
Entamoeba histolytica aldose reductase, putative 0.0045 0.0276 0.0833
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0365 0.0495
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.002 0.0056 0.0076
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0166 0.0226
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Brugia malayi Pre-SET motif family protein 0.0033 0.0166 0.0192
Echinococcus granulosus neurogenic locus notch protein 4 0.0136 0.1072 0.1072
Echinococcus multilocularis slit 2 protein 0.0136 0.1072 0.1457
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0225 0.0273
Giardia lamblia High cysteine protein 0.0136 0.1072 0.3763
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.002 0.0056 0.1138
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0067 0.0293
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0117 0.0228
Schistosoma mansoni notch 0.0136 0.1072 0.1428
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0489 0.4188 0.4188
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1601 0.5934
Echinococcus multilocularis voltage dependent calcium channel 0.0489 0.4188 0.5692
Leishmania major basic transcription factor 3a, putative 0.0037 0.0204 0.4124
Onchocerca volvulus 0.0045 0.0276 0.0376
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0117 0.0234
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0117 0.0234
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0073 0.0384
Plasmodium vivax SET domain protein, putative 0.0033 0.0166 0.2479
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.0398
Onchocerca volvulus 0.0045 0.0276 0.0376
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.0158
Mycobacterium ulcerans oxidoreductase 0.0045 0.0276 0.0856
Brugia malayi hypothetical protein 0.0849 0.7358 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0076
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0489 0.4188 0.5677
Schistosoma mansoni notch 0.0136 0.1072 0.1428
Loa Loa (eye worm) hypothetical protein 0.01 0.0764 0.1038
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0056 0.0209
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0045 0.0276 0.0343
Trichomonas vaginalis aldo/keto reductase, putative 0.0045 0.0276 0.1024
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0204 0.0885
Echinococcus multilocularis aldo keto reductase 0.0045 0.0276 0.0376
Onchocerca volvulus Peroxidase homolog 0.0849 0.7358 1
Toxoplasma gondii transporter, cation channel family protein 0.0114 0.0885 0.8227
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Echinococcus multilocularis GPCR, family 2 0.0017 0.0025 0.0034
Loa Loa (eye worm) hypothetical protein 0.0489 0.4188 0.5692
Echinococcus granulosus single minded 2 0.0039 0.0225 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.237 0.8783
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0092 0.0291
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0025 0.0034
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0489 0.0665
Loa Loa (eye worm) RNA binding protein 0.0069 0.0489 0.0665
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0275 0.2304 1
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0022 0.0073 0.0099
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.002 0.0056 0.065
Echinococcus multilocularis aldo keto reductase 0.0045 0.0276 0.0376
Echinococcus granulosus transcription factor btf3 0.0037 0.0204 0.0204
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0018 0.0035 0.0014
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Echinococcus granulosus thioredoxin glutathione reductase 0.007 0.0495 0.0495
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0025 0.0034
Echinococcus granulosus bloom syndrome protein 0.0023 0.0084 0.0084
Onchocerca volvulus Chorion peroxidase homolog 0.0849 0.7358 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0489 0.0633
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0098 0.0745 0.1013
Loa Loa (eye worm) thioredoxin reductase 0.007 0.0495 0.0672
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Brugia malayi PAS domain containing protein 0.0053 0.0347 0.044
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0117 0.2357
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0745 0.0982
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.2698 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0618 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.237 0.8783
Echinococcus multilocularis aldo keto reductase 0.0045 0.0276 0.0376
Toxoplasma gondii EGF family domain-containing protein 0.0136 0.1072 1
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.0067 0.0293
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.0092 0.1121
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0092 0.0539
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Schistosoma mansoni aldo-keto reductase 0.0045 0.0276 0.0343
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0489 0.4188 0.5692
Schistosoma mansoni voltage-gated cation channel 0.0489 0.4188 0.5677
Brugia malayi hypothetical protein 0.0179 0.1453 0.1947
Brugia malayi Delta serrate ligand family protein 0.0136 0.1072 0.1428
Onchocerca volvulus 0.0039 0.0225 0.0306
Brugia malayi Pre-SET motif family protein 0.0228 0.1886 0.2538
Brugia malayi Muscle positioning protein 4 0.0136 0.1072 0.1428
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Brugia malayi MH2 domain containing protein 0.0126 0.0991 0.1317
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0204 0.1782
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0034
Brugia malayi M-phase phosphoprotein, mpp8 0.0111 0.0855 0.1132
Brugia malayi Calcium binding EGF domain containing protein 0.0136 0.1072 0.1428
Echinococcus multilocularis neurogenic locus notch protein 4 0.0136 0.1072 0.1457
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0047 0.0173
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0204 0.0756
Echinococcus multilocularis neural cadherin 0.0136 0.1072 0.1457
Echinococcus multilocularis thioredoxin glutathione reductase 0.007 0.0495 0.0672
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.1256 1
Trypanosoma brucei aldo-keto reductase, putative 0.0045 0.0276 0.1102
Schistosoma mansoni septate junction protein 0.0136 0.1072 0.1428
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Leishmania major prostaglandin f synthase, putative 0.0045 0.0276 0.5588
Schistosoma mansoni aldo-keto reductase 0.0045 0.0276 0.0343
Loa Loa (eye worm) oxidoreductase 0.0045 0.0276 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0204 0.0756
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.237 0.8783
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0117 0.0234
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.237 0.8783
Schistosoma mansoni notch 0.0136 0.1072 0.1428
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.1853
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.0158
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Mycobacterium ulcerans hypothetical protein 0.0027 0.0117 0.0234
Onchocerca volvulus 0.0045 0.0276 0.0376
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0343 0.0466
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0225 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.1601 0.5934
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0024 0.0092 0.0138
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0166 0.0192
Loa Loa (eye worm) voltage-dependent calcium channel 0.0114 0.0885 0.1203
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0618 0.4918
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0489 0.4188 0.4188
Echinococcus multilocularis protein jagged 2 0.0136 0.1072 0.1457
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0155 0.0155
Mycobacterium ulcerans hypothetical protein 0.002 0.0056 0.0000089236
Loa Loa (eye worm) animal heme peroxidase 0.0849 0.7358 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0117 0.0125
Loa Loa (eye worm) hypothetical protein 0.0111 0.0855 0.1162
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0117 0.0125
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0092 0.072
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0024 0.0092 0.073
Onchocerca volvulus Dual oxidase homolog 0.0849 0.7358 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.0398
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0489 0.4188 0.5692
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0024 0.0092 0.0138
Brugia malayi hypothetical protein 0.0039 0.0225 0.0273
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0092 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.007 0.0495 0.2147
Mycobacterium leprae Conserved hypothetical protein 0.0025 0.0098 0.0781
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Plasmodium vivax glutathione reductase, putative 0.007 0.0495 0.7951
Brugia malayi Cadherin domain containing protein 0.0136 0.1072 0.1428
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.0092 0.034
Echinococcus granulosus neural cadherin 0.0136 0.1072 0.1072
Echinococcus granulosus hypothetical protein 0.0045 0.0276 0.0276
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.0092 0.124
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0489 0.0633
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0618 0.0808
Echinococcus granulosus protein jagged 2 0.0136 0.1072 0.1072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0025 0.0025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0047 0.0173
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0132 0.0571
Entamoeba histolytica aldose reductase, putative 0.0045 0.0276 0.0833
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.1256 0.4663
Loa Loa (eye worm) animal heme peroxidase 0.0849 0.7358 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.237 0.8783
Brugia malayi hypothetical protein 0.0019 0.0042 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0056 0.0252
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0204 0.0784
Schistosoma mansoni notch 0.0136 0.1072 0.1428
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0045 0.0276 0.0343
Brugia malayi GCC2 and GCC3 family protein 0.0136 0.1072 0.1428
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.237 0.8783
Loa Loa (eye worm) animal heme peroxidase 0.0849 0.7358 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Schistosoma mansoni hypothetical protein 0.0039 0.0225 0.0273
Trypanosoma brucei aldo/keto reductase, putative 0.002 0.0056 0.0136
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0045 0.0276 0.1024
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0117 0.0928
Loa Loa (eye worm) oxidoreductase 0.0045 0.0276 0.0376
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0025 0.0511
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0076
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0021 0.0067 0.0044
Echinococcus multilocularis neurogenic locus protein delta 0.0136 0.1072 0.1457
Echinococcus granulosus neurogenic locus notch protein 0.0136 0.1072 0.1072
Schistosoma mansoni slit 0.0136 0.1072 0.1428
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.0092 0.034
Brugia malayi glutaminase DH11.1 0.0312 0.2628 0.355
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0179
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0204 0.311
Schistosoma mansoni pol-related 0.0045 0.0276 0.0343
Loa Loa (eye worm) glutaminase 0.0312 0.2628 0.3572
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0025 0.0025
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0045 0.0276 0.5588
Echinococcus granulosus neurogenic locus protein delta 0.0136 0.1072 0.1072
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0489 0.0665
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.237 0.3221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0098 0.0745 0.0982
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0376 0.0511
Brugia malayi NADH-dependent xylose reductase 0.002 0.0056 0.0043
Schistosoma mansoni notch 0.0136 0.1072 0.1428
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0166 0.1424
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0092 0.1853
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0166 0.0226
Echinococcus granulosus protein jagged 1 0.0136 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0225 0.0658
Brugia malayi glutathione reductase 0.007 0.0495 0.064
Schistosoma mansoni laminin gamma-3 chain 0.0136 0.1072 0.1428
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0092 0.0398
Loa Loa (eye worm) notch protein 0.0136 0.1072 0.1457
Onchocerca volvulus 0.0849 0.7358 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0024 0.0092 0.0539
Trypanosoma brucei prostaglandin f synthase 0.0045 0.0276 0.1102
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0025 0.0034
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Echinococcus granulosus aldo keto reductase 0.0045 0.0276 0.0276
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0045 0.0276 0.1024
Onchocerca volvulus 0.0259 0.2163 0.294
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0025 0.011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0343 0.0466
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0045 0.0276 0.0343
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0025 0.0034
Schistosoma mansoni potassium channel beta 0.002 0.0056 0.0043
Trypanosoma cruzi aldo-keto reductase 0.0045 0.0276 0.1199
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0024 0.0092 0.0539
Leishmania major aldo-keto reductase-like protein 0.0045 0.0276 0.5588
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0076
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.0092 0.1121
Brugia malayi Animal haem peroxidase family protein 0.0849 0.7358 1
Echinococcus multilocularis neurogenic locus notch protein 0.0136 0.1072 0.1457
Echinococcus multilocularis aldo keto reductase 0.0045 0.0276 0.0376
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0489 0.4188 0.4188
Loa Loa (eye worm) RecQ helicase 0.0023 0.0084 0.0114
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0132 0.1906
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0092 0.0398
Loa Loa (eye worm) oxidoreductase 0.0045 0.0276 0.0376
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0045 0.0276 0.0343
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Trypanosoma brucei cytochrome P450, putative 0.0021 0.0067 0.0185
Leishmania major hypothetical protein, conserved 0.0029 0.0132 0.2662
Plasmodium falciparum thioredoxin reductase 0.007 0.0495 0.7923
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0084 0.0114
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0204 0.0885
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Onchocerca volvulus Slit protein homolog 0.0136 0.1072 0.1457
Onchocerca volvulus 0.0056 0.0376 0.0511
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0275 0.2304 1
Trypanosoma cruzi aldo/keto reductase, putative 0.002 0.0056 0.0244
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0136 0.1072 0.1428
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Schistosoma mansoni hypothetical protein 0.0186 0.1513 0.2029
Brugia malayi Cadherin domain containing protein 0.0136 0.1072 0.1428
Schistosoma mansoni peroxidasin 0.0849 0.7358 1
Schistosoma mansoni glutaminase 0.0312 0.2628 0.355
Onchocerca volvulus 0.0136 0.1072 0.1457
Loa Loa (eye worm) glutaminase 2 0.0312 0.2628 0.3572
Brugia malayi follicle stimulating hormone receptor 0.0256 0.2136 0.2879
Trichomonas vaginalis alcohol dehydrogenase, putative 0.002 0.0056 0.0209
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Echinococcus granulosus geminin 0.0186 0.1513 0.1513
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Trichomonas vaginalis set domain proteins, putative 0.0259 0.2163 0.8019
Trypanosoma cruzi aldo/keto reductase, putative 0.0045 0.0276 0.1199
Echinococcus multilocularis microtubule associated protein 2 0.073 0.631 0.8577
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.0092 0.124
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Schistosoma mansoni notch 0.0136 0.1072 0.1428
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0056 0.065
Echinococcus granulosus protein jagged 2 0.0136 0.1072 0.1072
Echinococcus granulosus tumor protein p63 0.0386 0.3278 0.3278
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0056 0.0911
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0084 0.0311
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0092 0.072
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0084 0.008
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0639
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0132 0.1098
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0639
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0024 0.0092 0.0138
Plasmodium falciparum glutathione reductase 0.0024 0.0092 0.1121
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0045 0.0276 0.1024
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.002 0.0056 0.0385
Loa Loa (eye worm) hypothetical protein 0.0022 0.0073 0.0099
Toxoplasma gondii aldose reductase, putative 0.0045 0.0276 0.2467
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0117 0.0742
Mycobacterium ulcerans endonuclease IV 0.0084 0.0618 0.2182
Plasmodium vivax aldehyde reductase, putative 0.002 0.0056 0.065
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0092 0.0091
Echinococcus multilocularis aldehyde reductase 0.0025 0.0098 0.0133
Loa Loa (eye worm) oxidoreductase 0.0045 0.0276 0.0376
Mycobacterium tuberculosis Probable oxidoreductase 0.0045 0.0276 0.204
Echinococcus multilocularis sodium channel protein 0.0175 0.1418 0.1928
Brugia malayi Thioredoxin reductase 0.007 0.0495 0.064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.1886 0.2563
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Trichomonas vaginalis aldo-keto reductase, putative 0.002 0.0056 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.0056 0.0076
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0618 0.4814
Brugia malayi beta-NAC-like protein 0.0037 0.0204 0.0244
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0092 0.0125
Onchocerca volvulus 0.0045 0.0276 0.0375
Loa Loa (eye worm) hypothetical protein 0.0111 0.0855 0.1162
Brugia malayi glutamate-cysteine ligase modifier subunit 0.002 0.0056 0.0043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.007 0.0495 0.3814
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0092 0.0398
Leishmania major cytochrome p450-like protein 0.0021 0.0067 0.1364
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0132 0.1795
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Onchocerca volvulus 0.0027 0.0117 0.0158
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0204 0.3016
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Brugia malayi EGF-like domain containing protein 0.0136 0.1072 0.1428
Echinococcus granulosus aldo keto reductase family 1, member B4 0.002 0.0056 0.0056
Onchocerca volvulus 0.0045 0.0276 0.0376
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Plasmodium vivax thioredoxin reductase, putative 0.007 0.0495 0.7951
Echinococcus granulosus notch 0.0136 0.1072 0.1072
Onchocerca volvulus 0.0136 0.1072 0.1457
Brugia malayi Peroxidasin 0.0849 0.7358 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0117 0.2357
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0166 0.0166
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0489 0.0633
Loa Loa (eye worm) hypothetical protein 0.0114 0.0885 0.1203
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0489 0.4188 0.5677
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0117 0.0234
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0117 0.0228
Brugia malayi Cytochrome P450 family protein 0.0055 0.0365 0.0463
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Echinococcus multilocularis geminin 0.0186 0.1513 0.2056
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.1853
Echinococcus granulosus fibropellin Ia 0.0136 0.1072 0.1072
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.1513 0.2056
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.002 0.0056 0.0385
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0117 0.0125
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0073 0.0063
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Loa Loa (eye worm) calcium channel 0.0489 0.4188 0.5692
Echinococcus granulosus tar DNA binding protein 0.0069 0.0489 0.0489
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0166 0.0192
Echinococcus granulosus delta-like protein 1 0.0136 0.1072 0.1072
Trichomonas vaginalis aldo-keto reductase, putative 0.002 0.0056 0.0209
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0018 0.0035 0.0014
Schistosoma mansoni peroxidasin 0.0849 0.7358 1
Leishmania major trypanothione reductase 0.007 0.0495 1
Brugia malayi Animal haem peroxidase family protein 0.0849 0.7358 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.0398
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0025 0.0092
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0045 0.0276 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0343 0.0433
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0343 0.0433
Loa Loa (eye worm) hypoxia-induced factor 1 0.0165 0.1331 0.1809
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0175 0.1418 0.1418
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0166 0.0192
Schistosoma mansoni hypothetical protein 0.0136 0.1072 0.1428
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0047 0.0173
Loa Loa (eye worm) CYP4Cod1 0.0021 0.0067 0.0092
Echinococcus multilocularis tumor protein p63 0.0386 0.3278 0.4455
Echinococcus multilocularis transcription factor btf3 0.0037 0.0204 0.0277
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Entamoeba histolytica hypothetical protein 0.0039 0.0225 0.0639
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0059 0.0567
Entamoeba histolytica aldose reductase, putative 0.0045 0.0276 0.0833
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.2698 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0092 0.0291
Onchocerca volvulus 0.0045 0.0276 0.0376
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0117 0.0234
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0489 0.0633
Onchocerca volvulus 0.0849 0.7358 1
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Echinococcus granulosus slit 2 protein 0.0136 0.1072 0.1072
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.0376 0.0478
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0132 0.1795
Onchocerca volvulus 0.0136 0.1072 0.1457
Brugia malayi Animal haem peroxidase family protein 0.0849 0.7358 1
Mycobacterium ulcerans hypothetical protein 0.0022 0.0073 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0196 0.0233
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.237 0.3198
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0204 0.0277
Schistosoma mansoni microtubule-associated protein tau 0.073 0.631 0.8572
Echinococcus granulosus protein jagged 1 0.0136 0.1072 0.1072
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0025 0.0134
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0225 0.0273
Brugia malayi TAR-binding protein 0.0069 0.0489 0.0633
Echinococcus multilocularis protein jagged 1 0.0136 0.1072 0.1457
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0092 0.5
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0618 1
Schistosoma mansoni hypothetical protein 0.0036 0.0196 0.0233
Echinococcus granulosus aldehyde reductase 0.0025 0.0098 0.0098
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0067 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0204 0.0756
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.0067 0.0092
Trichomonas vaginalis aldo/keto reductase, putative 0.0045 0.0276 0.1024
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.0204 0.0559
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0489 0.4188 0.5692
Mycobacterium tuberculosis Conserved protein 0.002 0.0056 0.0252
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0225 0.0225
Brugia malayi hypothetical protein 0.0111 0.0855 0.1132
Schistosoma mansoni single-minded 0.0053 0.0347 0.044
Brugia malayi Cytochrome P450 family protein 0.0021 0.0067 0.0058
Echinococcus multilocularis neurogenic locus protein delta 0.0136 0.1072 0.1457
Onchocerca volvulus 0.0111 0.0855 0.1162
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0489 0.0633
Brugia malayi Animal haem peroxidase family protein 0.0849 0.7358 1
Echinococcus granulosus microtubule associated protein 2 0.073 0.631 0.631
Onchocerca volvulus 0.0045 0.0276 0.0376
Giardia lamblia Aldose reductase 0.0045 0.0276 0.0709
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0092 0.0291
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0117 0.0742
Trichomonas vaginalis aldo/keto reductase, putative 0.0045 0.0276 0.1024
Mycobacterium ulcerans hypothetical protein 0.0227 0.1875 0.7072
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0025
Echinococcus granulosus voltage dependent calcium channel 0.0489 0.4188 0.4188
Onchocerca volvulus Peroxidasin homolog 0.0849 0.7358 1
Echinococcus multilocularis protein jagged 1 0.0136 0.1072 0.1457
Brugia malayi notch-like transmembrane receptor 0.0136 0.1072 0.1428
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.0398
Echinococcus granulosus voltage dependent calcium channel 0.0114 0.0885 0.0885
Onchocerca volvulus 0.0849 0.7358 1
Trichomonas vaginalis glutaminase, putative 0.0312 0.2628 0.9742
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0092 0.0291
Schistosoma mansoni transcription factor btf3 0.0037 0.0204 0.0244
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Loa Loa (eye worm) glutathione reductase 0.007 0.0495 0.0672
Loa Loa (eye worm) hypothetical protein 0.0033 0.0166 0.0226
Onchocerca volvulus 0.002 0.0056 0.0076
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0092 0.1853
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0073 0.0577
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.2698 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0136 0.1072 0.1457
Schistosoma mansoni hypothetical protein 0.0186 0.1513 0.2029
Echinococcus granulosus neurogenic locus notch protein 0.0136 0.1072 0.1072
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0024 0.0092 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0117 0.0928
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0045 0.0276 0.0376
Echinococcus multilocularis peroxidasin 0.0849 0.7358 1
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0136 0.1072 0.1428
Onchocerca volvulus 0.0111 0.0855 0.1162
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0347 0.044
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0045 0.0276 0.5588
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0025 0.0092
Brugia malayi Blistered cuticle protein 3 0.0849 0.7358 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0266
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0489 0.0633
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Loa Loa (eye worm) hypothetical protein 0.0084 0.0618 0.0839
Mycobacterium ulcerans epimerase 0.0022 0.0073 0.0063
Onchocerca volvulus Putative cubilin 0.0136 0.1072 0.1457
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0098 0.0745 0.0745
Trypanosoma brucei trypanothione reductase 0.007 0.0495 0.2059
Plasmodium falciparum glutathione reductase 0.007 0.0495 0.7923
Loa Loa (eye worm) blistered cuticle protein 3 0.0849 0.7358 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.0158
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0056 0.0523
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0041 0.0021
Echinococcus multilocularis fat cadherin tumor suppressor 0.0136 0.1072 0.1457
Toxoplasma gondii thioredoxin reductase 0.007 0.0495 0.4532
Trichomonas vaginalis aldo-keto reductase, putative 0.002 0.0056 0.0209
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0991 0.1347
Loa Loa (eye worm) hypothetical protein 0.0179 0.1453 0.1974
Chlamydia trachomatis endonuclease IV 0.0084 0.0618 1
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0136 0.1072 0.1457
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0092 0.0091
Echinococcus multilocularis neurogenic locus notch protein 0.0136 0.1072 0.1457
Loa Loa (eye worm) hypothetical protein 0.01 0.0764 0.1038
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0117 0.0228
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0489 0.4188 0.5692
Trichomonas vaginalis aldo-keto reductase, putative 0.0045 0.0276 0.1024
Toxoplasma gondii aldo-keto reductase 0.002 0.0056 0.0385
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1513 0.5608
Plasmodium falciparum thioredoxin reductase 0.0024 0.0092 0.1121
Brugia malayi RNA binding protein 0.0069 0.0489 0.0633
Loa Loa (eye worm) oxidoreductase 0.0045 0.0276 0.0376
Echinococcus granulosus voltage gated potassium channel subunit 0.002 0.0056 0.0056
Schistosoma mansoni cell polarity protein 0.0136 0.1072 0.1428
Brugia malayi Animal haem peroxidase family protein 0.0849 0.7358 1
Brugia malayi hypoxia-induced factor 1 0.0165 0.1331 0.1781
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0084 0.0311
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0092 0.0398
Onchocerca volvulus Peroxidasin homolog 0.0849 0.7358 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0034
Loa Loa (eye worm) animal heme peroxidase 0.0849 0.7358 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0256 0.2136 0.2903
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0117 0.0234
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.1256 1
Loa Loa (eye worm) hypothetical protein 0.0849 0.7358 1
Mycobacterium ulcerans glutaminase 0.0312 0.2628 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0025 0.011
Toxoplasma gondii endonuclease IV APN 0.0084 0.0618 0.5696
Brugia malayi Cytochrome P450 family protein 0.0021 0.0067 0.0058
Toxoplasma gondii hypothetical protein 0.01 0.0764 0.7078
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0117 0.0234
Echinococcus multilocularis voltage dependent calcium channel 0.0489 0.4188 0.5692
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0025 0.0034
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0045 0.0276 0.0276
Onchocerca volvulus Peroxidase homolog 0.0849 0.7358 1
Giardia lamblia Aldose reductase 0.0045 0.0276 0.0709
Loa Loa (eye worm) hypothetical protein 0.0136 0.1072 0.1457
Mycobacterium leprae Possible oxidoreductase 0.002 0.0056 0.0448
Loa Loa (eye worm) Notch2 0.0136 0.1072 0.1457
Echinococcus multilocularis fibropellin Ia 0.0136 0.1072 0.1457
Echinococcus granulosus aldo keto reductase 0.0045 0.0276 0.0276
Brugia malayi Calcium binding EGF domain containing protein 0.0136 0.1072 0.1428
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0489 0.4188 0.5677

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Biological activity of the compound was tested against rat liver 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGR) at a concentration of 10E-4 M; No inhibition ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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