Detailed information for compound 278271

Basic information

Technical information
  • TDR Targets ID: 278271
  • Name: 1-cyclopropyl-6-fluoro-4-oxo-7-(4-pyridin-2-y lpiperazin-1-yl)-8-(trifluoromethyl)quinoline -3-carboxylic acid
  • MW: 476.424 | Formula: C23H20F4N4O3
  • H donors: 1 H acceptors: 4 LogP: 4.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cc2c(c(c1N1CCN(CC1)c1ccccn1)C(F)(F)F)n(cc(c2=O)C(=O)O)C1CC1
  • InChi: 1S/C23H20F4N4O3/c24-16-11-14-19(31(13-4-5-13)12-15(21(14)32)22(33)34)18(23(25,26)27)20(16)30-9-7-29(8-10-30)17-3-1-2-6-28-17/h1-3,6,11-13H,4-5,7-10H2,(H,33,34)
  • InChiKey: GRJJETOERCNXLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-cyclopropyl-6-fluoro-4-oxo-7-[4-(2-pyridyl)piperazin-1-yl]-8-(trifluoromethyl)quinoline-3-carboxylic acid
  • 1-cyclopropyl-6-fluoro-4-oxo-7-[4-(2-pyridyl)-1-piperazinyl]-8-(trifluoromethyl)-3-quinolinecarboxylic acid
  • 1-cyclopropyl-6-fluoro-4-keto-7-[4-(2-pyridyl)piperazino]-8-(trifluoromethyl)quinoline-3-carboxylic acid
  • 1-cyclopropyl-6-fluoro-4-keto-7-[4-(2-pyridyl)piperazin-1-yl]-8-(trifluoromethyl)quinoline-3-carboxylic acid
  • AIDS058529
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(2-pyridinyl)-1-piperazinyl]-8-(trifluoromethyl)-
  • AIDS-058529

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0992 0.3755
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0119 0.043
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0114 0.0409
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0057 0.016 0.1291
Leishmania major DNA polymerase eta, putative 0.0018 0.0015 0.0009
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0242 0.0896
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0063 0.0179 0.0167
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0036 0.021
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0175 0.0622
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0017 0.0012 0.0037
Plasmodium vivax acyl-CoA synthetase, putative 0.0043 0.0107 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0043 0.0107 0.0829
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0114 0.4418
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0072 0.0251
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0072 0.0251
Trichomonas vaginalis reverse transcriptases, putative 0.0063 0.0179 0.0635
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0072 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0163 0.0592
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0016 0.0037
Onchocerca volvulus 0.0063 0.0179 0.065
Onchocerca volvulus 0.0057 0.016 0.0578
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0008 0.0006
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0063 0.0179 0.0657
Schistosoma mansoni tyrosine kinase 0.0173 0.0582 0.058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0072 0.007
Brugia malayi nuclear receptor RXR 0.0018 0.0015 0.0026
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0072 0.007
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0036 0.0024
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0046 0.0119 0.043
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus granulosus dna polymerase kappa 0.005 0.0132 0.0478
Echinococcus multilocularis insulin receptor 0.0107 0.0341 0.1275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0099 0.4413
Echinococcus multilocularis tumor protein p63 0.0409 0.1438 0.5456
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.016 0.1291
Brugia malayi nuclear receptor NHR-88 0.0033 0.0072 0.0244
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.0015 0.0058
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0072 0.0251
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0063 0.0179 0.0167
Brugia malayi RNase H family protein 0.0737 0.2631 1
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0063 0.0179 0.0635
Schistosoma mansoni tyrosine kinase 0.0107 0.0341 0.0339
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0063 0.0179 0.065
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0083 0.0081
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0175 0.0163
Brugia malayi Pre-SET motif family protein 0.0252 0.0867 0.3275
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0175 0.0622
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0097 0.4325
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0072 0.0251
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0008 0.0007
Trichomonas vaginalis reverse transcriptases, putative 0.0063 0.0179 0.0635
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0072 0.0558
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0072 0.007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.0015 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0057 0.016 0.727
Schistosoma mansoni nephrin 0.0015 0.0006 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0072 0.0244
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0063 0.0179 0.0177
Plasmodium falciparum acyl-CoA synthetase 0.0043 0.0107 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0008 0.0007
Schistosoma mansoni nuclear receptor 0.0016 0.0008 0.0006
Schistosoma mansoni acetyl-CoA synthetase 0.0017 0.0012 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0114 0.0387
Loa Loa (eye worm) TK protein kinase 0.0033 0.0072 0.0555
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0072 0.0251
Schistosoma mansoni tyrosine kinase 0.0178 0.0599 0.0597
Brugia malayi polk-prov protein 0.0038 0.0088 0.0304
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.0044 0.012
Schistosoma mansoni tyrosine kinase 0.0205 0.0698 0.0696
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0132 0.012
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0046 0.0119 0.043
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0016 0.0014
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0242 0.0876
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0992 0.3755
Brugia malayi RNase H family protein 0.0737 0.2631 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0083 0.0283
Brugia malayi Furin-like cysteine rich region family protein 0.0329 0.1148 0.4346
Schistosoma mansoni inositol monophosphatase 0.0045 0.0114 0.0112
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0119 0.043
Echinococcus multilocularis tyrosine protein kinase HCK 0.0033 0.0072 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0088 0.0076
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0242 0.2037
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0175 0.0667
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0057 0.016 0.1291
Brugia malayi Zinc knuckle family protein 0.0063 0.0179 0.065
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0063 0.0179 0.0177
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0218 0.0808
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0036 0.0092
Schistosoma mansoni protein kinase 0.0063 0.0179 0.0177
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0072 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0218 0.1804
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0015 0.0033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0083 0.029
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0119 0.043
Schistosoma mansoni tyrosine kinase 0.0046 0.0119 0.0117
Echinococcus multilocularis RNA directed DNA polymerase 0.0063 0.0179 0.0657
Brugia malayi hypothetical protein 0.0063 0.0179 0.065
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0072 0.0244
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0017 0.0012 0.0016
Brugia malayi reverse transcriptase 0.0063 0.0179 0.065
Echinococcus granulosus roundabout 2 0.0018 0.0017 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.006
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0046 0.0119 0.043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.006
Echinococcus multilocularis tyrosine protein kinase Srms 0.004 0.0096 0.0341
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0043 0.0107 0.481
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.016 0.1291
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0063 0.0179 0.0167
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0057 0.016 0.1291
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0178 0.0599 0.2259
Echinococcus granulosus KRAB A domain containing protein 0.0063 0.0179 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0012
Loa Loa (eye worm) TK/EGFR protein kinase 0.0329 0.1148 0.9946
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0072 0.0558
Schistosoma mansoni zinc finger protein 0.0016 0.0008 0.0006
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0242 0.0876
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus granulosus tyrosine protein kinase Src64B 0.0046 0.0119 0.043
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.0401 0.1499
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.004 0.0096 0.0341
Loa Loa (eye worm) oxidoreductase 0.0017 0.0012 0.0036
Trypanosoma brucei protein kinase, putative 0.0062 0.0175 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0072 0.0558
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0008 0.0007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0867 0.7494
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0114 0.0387
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0114 0.0101
Schistosoma mansoni nuclear receptor 0.0016 0.0008 0.0006
Schistosoma mansoni tyrosine kinase 0.0329 0.1148 0.1146
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0012 0.0016
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0114 0.0387
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0097 0.5715
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0083 0.0314
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0078
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0175 0.0644
Brugia malayi hypothetical protein 0.0018 0.0015 0.0026
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0017 0.0012 0.0397
Echinococcus multilocularis dna polymerase kappa 0.005 0.0132 0.0478
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0175 0.0622
Mycobacterium ulcerans hypothetical protein 0.0057 0.016 0.1291
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0072 0.0251
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0072 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0132 0.0456
Schistosoma mansoni tyrosine kinase 0.0107 0.0341 0.0339
Loa Loa (eye worm) hypothetical protein 0.006 0.0169 0.1401
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0063 0.0179 0.0657
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0008 0.0007
Schistosoma mansoni tyrosine kinase 0.0018 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0286 0.0992 0.8583
Onchocerca volvulus 0.0287 0.0994 0.3757
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0083 0.029
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0175 0.0644
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0036 0.0246
Loa Loa (eye worm) hypothetical protein 0.0057 0.016 0.1323
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0017 0.0012 0.0397
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0169 0.0167
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0072 0.0251
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0072 0.007
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Brugia malayi Zinc knuckle family protein 0.0063 0.0179 0.065
Loa Loa (eye worm) hypothetical protein 0.0107 0.0339 0.2886
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0017 0.0012 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.0015 0.0009
Brugia malayi hypothetical protein 0.0018 0.0015 0.0026
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 0.0132 0.0456
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0072 0.007
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0114 0.0387
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0017 0.0012 0.0397
Brugia malayi steroid hormone receptor 0.0033 0.0072 0.0244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0072 0.0244
Trypanosoma brucei ingi protein (ORF1) 0.0799 0.2858 0.285
Trypanosoma brucei unspecified product 0.0799 0.2858 0.285
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0175 0.0622
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0072 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Echinococcus granulosus epidermal growth factor receptor 0.0178 0.0599 0.2259
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.0015 0.0002
Loa Loa (eye worm) inositol-1 0.0045 0.0114 0.092
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0017 0.0012 0.0047
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0242 0.0896
Trypanosoma brucei RNA helicase, putative 0.2762 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0082 0.0642
Loa Loa (eye worm) hypothetical protein 0.0107 0.0339 0.2886
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0046 0.0119 0.043
Echinococcus granulosus epidermal growth factor receptor 0.0329 0.1148 0.435
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0015 0.0026
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.0015 0.0013
Schistosoma mansoni survival motor neuron protein 0.0058 0.0163 0.0162
Echinococcus granulosus tyrosine protein kinase Blk 0.004 0.0096 0.0341
Echinococcus granulosus dna polymerase eta 0.0018 0.0015 0.0032
Brugia malayi Cytochrome P450 family protein 0.0023 0.0036 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0099 0.4413
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0212 0.0722 0.2726
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0132 0.0456
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0046 0.0119 0.043
Brugia malayi hypothetical protein 0.0063 0.0179 0.065
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0063 0.0179 0.0657
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0072 0.0244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0015 0.006
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0242 0.023
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0036 0.0092
Brugia malayi ecdysteroid receptor 0.0033 0.0072 0.0244
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0114 0.0887
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0016 0.0037
Brugia malayi Cytochrome P450 family protein 0.0036 0.0082 0.0281
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0072 0.0244
Brugia malayi AMP-binding enzyme family protein 0.0057 0.016 0.0578
Trypanosoma cruzi ribonuclease H1, putative 0.0737 0.2631 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0107 0.0862
Loa Loa (eye worm) hypothetical protein 0.0043 0.0107 0.0862
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Loa Loa (eye worm) hypothetical protein 0.0036 0.0083 0.0648
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0175 0.0622
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0072 0.0244
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0063 0.0179 0.0657
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0008 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.0181 0.0179
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0063 0.0179 0.0521
Mycobacterium tuberculosis Possible maturase 0.0063 0.0179 0.8153
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0175 0.0622
Echinococcus multilocularis tyrosine protein kinase Blk 0.004 0.0096 0.0341
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0046 0.0119 0.043
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0012 0.0016
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0008 0.0006
Onchocerca volvulus 0.0036 0.0083 0.0283
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0119 0.043
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0016 0.0037
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0063 0.0179 0.0521
Brugia malayi MAP kinase sur-1 0.0062 0.0175 0.0637
Onchocerca volvulus Ribonuclease H1 homolog 0.0737 0.2631 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0107 0.0862
Brugia malayi hypothetical protein 0.0286 0.0992 0.375
Echinococcus granulosus insulin receptor 0.0107 0.0341 0.1275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0072 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.0044 0.0032
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0063 0.0179 0.0657
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0063 0.0179 0.0635
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0072 0.0251
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0132 0.1046
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0799 0.2858 0.285
Loa Loa (eye worm) hypothetical protein 0.0043 0.0107 0.0862
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0072 0.007
Leishmania major ribonuclease H1, putative 0.0737 0.2631 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0017 0.0012 0.0397
Schistosoma mansoni tyrosine kinase 0.0173 0.0582 0.058
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0008 0.0007
Toxoplasma gondii ribonuclease HI protein 0.0737 0.2631 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0248 0.2088
Brugia malayi reverse transcriptase 0.0063 0.0179 0.065
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0103 0.0091
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0218 0.1804
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0046 0.0119 0.043
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0072 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Loa Loa (eye worm) TK/INSR protein kinase 0.0107 0.0341 0.2904
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0078 0.0272
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0132 0.0456
Echinococcus granulosus tyrosine protein kinase HCK 0.0033 0.0072 0.0249
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0175 0.0622
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0036
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0175 0.0622
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0175 0.0508
Brugia malayi hypothetical protein 0.0107 0.0339 0.1261
Onchocerca volvulus 0.006 0.0169 0.0612
Brugia malayi AMP-binding enzyme family protein 0.0057 0.016 0.0578
Echinococcus multilocularis epidermal growth factor receptor 0.0329 0.1148 0.435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0072 0.0558
Onchocerca volvulus 0.0017 0.0012 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0072 0.0244
Trichomonas vaginalis DNA polymerase eta, putative 0.005 0.0132 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0036 0.0246
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0008 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0072 0.0244
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0072 0.0244
Loa Loa (eye worm) SRC-1 0.0046 0.0119 0.0968
Brugia malayi Immunoglobulin I-set domain containing protein 0.0017 0.0012 0.0016
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.016 0.0563
Brugia malayi nuclear hormone receptor 0.0033 0.0072 0.0244
Trypanosoma cruzi ribonuclease H1, putative 0.0737 0.2631 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0242 1
Trypanosoma brucei unspecified product 0.0042 0.0103 0.0091
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0119 0.043
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0083 0.029
Echinococcus granulosus ribonuclease H1 0.0737 0.2631 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0114 0.0432
Giardia lamblia Reverse transcriptase/endonuclease 0.0063 0.0179 0.0521
Entamoeba histolytica protein kinase, putative 0.0033 0.0072 0.2594
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0017 0.0012 0.0023
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.016 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0072 0.007
Schistosoma mansoni tyrosine kinase 0.0018 0.0016 0.0014
Echinococcus multilocularis roundabout 2 0.0018 0.0017 0.0041
Schistosoma mansoni eyes absent homolog 0.0107 0.0339 0.0337
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0008 0.0007
Onchocerca volvulus 0.0017 0.0012 0.0016
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0017 0.0012 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0088 0.0695
Schistosoma mansoni DNA polymerase eta 0.0018 0.0015 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0057 0.016 0.0578
Treponema pallidum ribonuclease H (rnhA) 0.0737 0.2631 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0057 0.016 0.643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0072 0.0558
Brugia malayi glutaminase DH11.1 0.0331 0.1154 0.437
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0088 0.0076
Schistosoma mansoni inositol monophosphatase 0.0045 0.0114 0.0112
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0737 0.2631 1
Leishmania major DNA polymerase kappa, putative 0.0025 0.0044 0.012
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Echinococcus multilocularis 0.0101 0.0318 0.1188
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0036 0.0246
Loa Loa (eye worm) hypothetical protein 0.0057 0.016 0.1323
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0063 0.0179 0.0177
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Schistosoma mansoni phosphoglucomutase 0.0737 0.2631 0.2629
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.016 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0072 0.0244
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0072 0.0244
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0175 0.0622
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 0.0132 0.0456
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Leishmania major cytochrome p450-like protein 0.0023 0.0036 0.0092
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0015 0.0033
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Loa Loa (eye worm) TK protein kinase 0.004 0.0096 0.0764
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.0015 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0218 0.1804
Echinococcus granulosus RNA directed DNA polymerase 0.0063 0.0179 0.0657
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Onchocerca volvulus 0.0017 0.0012 0.0016
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0015 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0072 0.0244
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0072 0.0244
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0072 0.0244
Mycobacterium ulcerans DNA polymerase IV 0.005 0.0132 0.1046
Brugia malayi protein-tyrosine kinase 0.004 0.0096 0.0334
Onchocerca volvulus 0.0058 0.0163 0.0592
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0083 0.0081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0218 0.0787
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0008 0.0007
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0017 0.0012 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0083 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0072 0.0244
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0072 0.0251
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0024 0.0012
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0017 0.0012 0.0397
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0017 0.0012 0.0397
Schistosoma mansoni tyrosine kinase 0.0046 0.0119 0.0117
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0072 0.0251
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0008 0.0007
Onchocerca volvulus 0.0033 0.0072 0.0244
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0994 0.3747
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0012 0.0397
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Echinococcus granulosus tyrosine kinase 0.004 0.0096 0.0341
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0017 0.0012 0.0397
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0015 0.0026
Loa Loa (eye worm) hypothetical protein 0.0043 0.0107 0.0862
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0132 0.012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0119 0.043
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0072 0.007
Trypanosoma brucei ingi protein (ORF1) 0.0799 0.2858 0.285
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0012 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0072 0.0251
Mycobacterium ulcerans glutaminase 0.0331 0.1154 1
Brugia malayi hypothetical protein 0.0063 0.0179 0.065
Loa Loa (eye worm) hypothetical protein 0.0057 0.016 0.1323
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0175 0.0644
Echinococcus multilocularis dna polymerase eta 0.0018 0.0015 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0218 0.083
Schistosoma mansoni tyrosine kinase 0.0173 0.0582 0.058
Trichomonas vaginalis glutaminase, putative 0.0331 0.1154 0.4361
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0242 0.0876
Trypanosoma brucei ribonuclease H1 0.0737 0.2631 0.2622
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0078 0.0273
Echinococcus multilocularis ribonuclease H1 0.0737 0.2631 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0046 0.0119 0.043
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0012 0.0016
Trypanosoma brucei hypothetical protein, conserved 0.0799 0.2858 0.285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0015 0.0013
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0072 0.0251
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0218 0.0216
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0072 0.0251
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0218 0.0808
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0072 0.0244
Brugia malayi Tyrosine-protein kinase abl-1 0.0094 0.0295 0.1093
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0242 0.089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0083 0.0081
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0008 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0072 0.007
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0114 0.0409
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0099 0.4413
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0175 0.1459
Toxoplasma gondii propionate-CoA ligase 0.0017 0.0012 0.0047
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0218 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0072 0.0251
Brugia malayi Cytochrome P450 family protein 0.0023 0.0036 0.0107
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.0179 0.0635
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0057 0.016 1
Brugia malayi RNase H family protein 0.0737 0.2631 1
Onchocerca volvulus 0.0063 0.0179 0.065
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0175 0.0622
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0119 0.043
Trichomonas vaginalis ribonuclease H1, putative 0.0737 0.2631 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0012 0.0397
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0016 0.0037
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0046 0.0119 0.043
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0107 0.0341 0.1275
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.0015 0.051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0072 0.007
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.0015 0.0025
Brugia malayi hypothetical protein 0.0063 0.0179 0.065
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0078 0.0273
Schistosoma mansoni tyrosine kinase 0.0178 0.0599 0.0597
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0063 0.0179 0.0521
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0057 0.016 0.727
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0072 0.0251
Echinococcus multilocularis tyrosine protein kinase Abl 0.0094 0.0295 0.1099
Brugia malayi Protein kinase domain containing protein 0.0107 0.0341 0.1269
Leishmania major 4-coumarate:coa ligase-like protein 0.0057 0.016 0.0563
Loa Loa (eye worm) TK/ABL protein kinase 0.0212 0.0722 0.6226
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Brugia malayi reverse transcriptase 0.0063 0.0179 0.065
Schistosoma mansoni phosphoglucomutase 0.0737 0.2631 0.2629
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.0015 0.0106
Brugia malayi Inositol-1 0.0045 0.0114 0.0402
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0121 0.0437
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0008 0.0006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.016 0.643
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.016 0.1291
Schistosoma mansoni glutaminase 0.0331 0.1154 0.1152
Echinococcus granulosus tyrosine protein kinase ABL1 0.0212 0.0722 0.2726
Mycobacterium ulcerans acyl-CoA synthetase 0.0057 0.016 0.1291
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0096 0.0341
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0012 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0218 0.0216
Schistosoma mansoni coup transcription factor 0.0033 0.0072 0.007
Echinococcus granulosus twitchin 0.0016 0.0009 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0072 0.0244
Brugia malayi SRC-1 0.0046 0.0119 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0072 0.0558
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0114 0.0387
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0114 0.0387
Onchocerca volvulus 0.0017 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.006
Loa Loa (eye worm) glutaminase 0.0331 0.1154 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0015 0.0013
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0012 0.0397
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0072 0.0558
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0063 0.0179 0.0521
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0072 0.0251
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0107 0.0341 0.1275
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0012 0.0397
Echinococcus multilocularis epidermal growth factor receptor 0.0178 0.0599 0.2259
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.0044 0.1864
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0072 0.0251
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0175 0.0644
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0242 0.024
Schistosoma mansoni hypothetical protein 0.0058 0.0163 0.0162
Trypanosoma brucei DNA polymerase IV, putative 0.005 0.0132 0.012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0041 0.0099 0.4413
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0063 0.0179 0.0657
Echinococcus granulosus tumor protein p63 0.0409 0.1438 0.5456
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0008 0.0006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0043 0.0107 0.5
Plasmodium vivax SET domain protein, putative 0.0036 0.0083 0.7406
Echinococcus granulosus tyrosine protein kinase Fyn 0.0046 0.0119 0.043
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.0015 0.0032
Loa Loa (eye worm) glutaminase 2 0.0331 0.1154 1
Schistosoma mansoni phosphoglucomutase 0.0737 0.2631 0.2629
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0017 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0033 0.0072 0.0558
Giardia lamblia Ribonuclease H 0.0737 0.2631 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0057 0.016 0.643
Loa Loa (eye worm) hypothetical protein 0.0017 0.0012 0.0036
Loa Loa (eye worm) hypothetical protein 0.0018 0.0015 0.006
Brugia malayi Pao retrotransposon peptidase family protein 0.0063 0.0179 0.065
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0175 0.0173

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) 0 ug hr ml-1 Area under curve was determined using trapezoidal rule after oral administration in cynomolgus monkeys; ND means Not determined ChEMBL. 11858992
AUC (ADMET) = 3.5 ug hr ml-1 Area under curve was determined using trapezoidal rule after intravenous administration in cynomolgus monkeys ChEMBL. 11858992
AUC (ADMET) = 24.93 ug hr ml-1 Area under curve (AUC) was calculated using trapezoidal ruleat a dose of 20 mg/kg in rats ChEMBL. 11858992
BA (ADMET) = 4.3 % Bioavailability of the compound was reported in cynomolgus monkeys (ratio of AUC in oral administration to that of intravenous administration) ChEMBL. 11858992
CC50 (functional) = 1.4 uM The compound was tested for cytotoxicity against mock-infected MT-4 cells. ChEMBL. 11858992
CC50 (functional) = 1.4 uM The compound was tested for cytotoxicity against mock-infected MT-4 cells. ChEMBL. 11858992
CLtotal (ADMET) NA 0 ml hr-1 kg-1 The total clearance was determined after oral administration in cynomolgus monkeys; NA means Not applicable ChEMBL. 11858992
CLtotal (ADMET) = 293.5 ml hr-1 kg-1 The total clearance was determined after intravenous administration in cynomolgus monkeys ChEMBL. 11858992
Cmax (ADMET) NA 0 ug ml-1 The peak concentration (Cmax) value of the compound was determined after intravenous administration in cynomolgus monkeys; NA means Not applicable ChEMBL. 11858992
Cmax (ADMET) = 0.1 ug ml-1 The peak concentration (Cmax) value of the compound was determined after oral administration in cynomolgus monkeys ChEMBL. 11858992
Cmax (ADMET) = 5.83 ug ml-1 Peak concentration (Cmax) of the compound was determined at a dose of 20 mg/kg in rats ChEMBL. 11858992
IC50 (functional) = 0.065 uM The compound was tested against HIV-1(IIIB) replication on the inhibition of virus -induced cytopathogenicity in MT-4 cells. ChEMBL. 11858992
IC50 (functional) = 0.065 uM The compound was tested against HIV-1(IIIB) replication on the inhibition of virus -induced cytopathogenicity in MT-4 cells. ChEMBL. 11858992
MRT (ADMET) NA 0 hr Mean residence time was determined after oral administration in cynomolgus monkeys; NA means Not applicable ChEMBL. 11858992
MRT (ADMET) = 0.8 hr Mean residence time was determined after intravenous administration in cynomolgus monkeys ChEMBL. 11858992
T max (ADMET) NA 0 hr The time for peak concentration value of the compound was determined after intravenous administration in cynomolgus monkeys; NA means Not applicable ChEMBL. 11858992
T max (ADMET) = 2 hr Time for peak concentration (tmax) of the compound was determined at a dose of 20 mg/kg in rats ChEMBL. 11858992
T max (ADMET) = 2 hr The time for peak concentration value of the compound was determined after oral administration in cynomolgus monkeys ChEMBL. 11858992
T1/2 (ADMET) 0 hr Half-life period of the compound was determined after oral administration in cynomolgus monkeys; ND meansn Not determined ChEMBL. 11858992
T1/2 (ADMET) = 0.7 hr Half-life period of the compound was determined after intravenous administration in cynomolgus monkeys ChEMBL. 11858992
Vdss (ADMET) NA 0 ml kg-1 The distribution volume of the compound was determined after oral administration in cynomolgus monkeys; NA means Not applicable ChEMBL. 11858992
Vdss (ADMET) = 224.5 ml kg-1 The distribution volume of the compound was determined after intravenous administration in cynomolgus monkeys ChEMBL. 11858992

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11858992

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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