Detailed information for compound 289726

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.438 | Formula: C16H24N2O4S
  • H donors: 3 H acceptors: 3 LogP: 0.88 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)[C@@H](NC(=O)C([C@@H](CSCc1ccccc1)N)O)C
  • InChi: 1S/C16H24N2O4S/c1-3-22-16(21)11(2)18-15(20)14(19)13(17)10-23-9-12-7-5-4-6-8-12/h4-8,11,13-14,19H,3,9-10,17H2,1-2H3,(H,18,20)/t11-,13+,14?/m0/s1
  • InChiKey: WAUFRWRDADWDFP-MKDGSZCOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei epsilon tubulin 0.013 0.1326 0.5159
Schistosoma mansoni tubulin subunit beta 0.024 0.257 0.5424
Trichomonas vaginalis tubulin gamma chain, putative 0.0057 0.0494 0.108
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.151 0.5876
Loa Loa (eye worm) tubulin beta chain 0.024 0.257 1
Echinococcus granulosus beta tubulin 0.024 0.257 0.2513
Trypanosoma brucei beta tubulin 0.024 0.257 1
Schistosoma mansoni tubulin subunit beta 0.024 0.257 0.5424
Trypanosoma brucei alpha tubulin, putative 0.0074 0.0687 0.2674
Schistosoma mansoni cpg binding protein 0.003 0.0193 0.0255
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0076 0.0296
Loa Loa (eye worm) tubulin alpha-2 chain 0.0182 0.1908 0.7426
Echinococcus multilocularis tubulin delta chain 0.0057 0.0494 0.0421
Leishmania major beta tubulin 0.024 0.257 1
Echinococcus multilocularis tubulin epsilon chain 0.013 0.1326 0.1259
Schistosoma mansoni hypothetical protein 0.0177 0.1852 0.3861
Loa Loa (eye worm) hypothetical protein 0.01 0.0987 0.3839
Trypanosoma brucei tubulin gamma chain 0.013 0.1326 0.5159
Echinococcus multilocularis tubulin beta 1 chain 0.024 0.257 0.2513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0076 0.0296
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0058 0.0505 0.1966
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0353 0.0279
Trypanosoma cruzi epsilon tubulin, putative 0.013 0.1326 0.5159
Echinococcus granulosus muscleblind protein 0.0156 0.1615 0.1551
Schistosoma mansoni tubulin subunit epsilon 0.013 0.1326 0.2718
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0379 0.1474
Trichomonas vaginalis tubulin gamma chain, putative 0.024 0.257 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0182 0.1908 0.1846
Trichomonas vaginalis tubulin alpha chain, putative 0.0074 0.0687 0.1912
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.1015 0.0946
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.151 0.5876
Echinococcus multilocularis tubulin alpha 1C chain 0.0182 0.1908 0.1846
Echinococcus granulosus neuropeptide receptor A26 0.0899 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Schistosoma mansoni alpha-glucosidase 0.0133 0.1357 0.2786
Trichomonas vaginalis tubulin epsilon chain, putative 0.024 0.257 1
Schistosoma mansoni hypothetical protein 0.0042 0.0335 0.0563
Echinococcus multilocularis Tubulin beta 2C chain 0.024 0.257 0.2513
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0353 0.0279
Brugia malayi Tubulin beta chain 0.0074 0.0687 0.2674
Trypanosoma cruzi tubulin delta chain 0.0057 0.0494 0.1921
Trichomonas vaginalis tubulin, putative 0.0074 0.0687 0.1912
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0155 0.16 0.6226
Echinococcus multilocularis expressed conserved protein 0.0097 0.0945 0.0875
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0076 0.0296
Leishmania major beta tubulin 0.024 0.257 1
Plasmodium vivax tubulin gamma chain, putative 0.013 0.1326 0.49
Echinococcus granulosus peroxisome assembly protein 26 0.0182 0.1908 0.1846
Loa Loa (eye worm) tubulin beta-1 chain 0.024 0.257 1
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0076 0.0296
Schistosoma mansoni hypothetical protein 0.0042 0.0335 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0076 0.0296
Loa Loa (eye worm) TK/EGFR protein kinase 0.0156 0.1612 0.6273
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0835 0.0764
Leishmania major beta tubulin 0.024 0.257 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.024 0.257 0.2513
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.1033 0.2081
Leishmania major beta tubulin 0.024 0.257 1
Loa Loa (eye worm) tubulin beta chain 0.0057 0.0494 0.1921
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0353 0.1373
Trypanosoma brucei glucosidase, putative 0.0034 0.0242 0.0943
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0076 0.0296
Onchocerca volvulus 0.0074 0.0687 0.7755
Schistosoma mansoni tyrosine kinase 0.0156 0.1612 0.3341
Schistosoma mansoni tubulin subunit alpha 0.0182 0.1908 0.3985
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0182 0.1908 0.7158
Trypanosoma brucei alpha tubulin 0.0182 0.1908 0.7426
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.1908 0.7158
Schistosoma mansoni tubulin subunit beta 0.024 0.257 0.5424
Mycobacterium ulcerans cell division protein FtsZ 0.0057 0.0494 0.9769
Trypanosoma brucei beta tubulin 0.024 0.257 1
Echinococcus multilocularis muscleblind protein 1 0.0156 0.1615 0.1551
Trypanosoma brucei tubulin delta chain 0.0057 0.0494 0.1921
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0125 0.127 0.4941
Loa Loa (eye worm) hypothetical protein 0.0125 0.127 0.4941
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0076 0.0296
Echinococcus granulosus tubulin subunit TubB 0.0182 0.1908 0.1846
Echinococcus multilocularis tubulin gamma 1 chain 0.013 0.1326 0.1259
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.0799 0.0729
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0455 0.1772
Schistosoma mansoni tubulin subunit alpha 0.0057 0.0494 0.0908
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0505 1
Schistosoma mansoni tyrosine kinase 0.0084 0.0799 0.1572
Schistosoma mansoni tyrosine kinase 0.005 0.0417 0.074
Plasmodium falciparum alpha tubulin 1 0.0182 0.1908 0.7288
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.151 0.5876
Plasmodium falciparum tubulin epsilon chain, putative 0.013 0.1326 0.49
Toxoplasma gondii beta-tubulin, putative 0.024 0.257 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0076 0.0296
Echinococcus multilocularis neutral alpha glucosidase AB 0.0034 0.0242 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0242 0.0943
Giardia lamblia Alpha-tubulin 0.0182 0.1908 0.6872
Brugia malayi steroid hormone receptor 0.002 0.0076 0.0296
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0496 0.1499
Loa Loa (eye worm) TK/INSR protein kinase 0.005 0.0417 0.1621
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.257 1
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.1908 0.7158
Toxoplasma gondii beta-1 tubulin, putative 0.024 0.257 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.1908 0.1846
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0455 0.1772
Entamoeba histolytica tubulin gamma chain 0.013 0.1326 0.49
Echinococcus multilocularis Tubulin beta 2C chain 0.024 0.257 0.2513
Echinococcus granulosus GPCR family 2 0.0046 0.0379 0.0305
Echinococcus granulosus tubulin alpha chain 0.0182 0.1908 0.1846
Schistosoma mansoni hypothetical protein 0.0042 0.0335 0.0563
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0455 0.0382
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0057 0.0494 0.108
Trypanosoma brucei epsilon tubulin 0.013 0.1326 0.5159
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0799 0.0729
Trichomonas vaginalis tubulin, putative 0.024 0.257 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0057 0.0494 0.1489
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0076 0.0296
Giardia lamblia Beta tubulin 0.024 0.257 1
Echinococcus multilocularis tubulin subunit beta 0.024 0.257 0.2513
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Trichomonas vaginalis tubulin alpha chain, putative 0.0074 0.0687 0.1912
Trichomonas vaginalis tubulin epsilon chain, putative 0.0182 0.1908 0.7158
Plasmodium vivax tubulin epsilon chain, putative 0.013 0.1326 0.49
Loa Loa (eye worm) tubulin alpha chain 0.0182 0.1908 0.7426
Brugia malayi Protein kinase domain containing protein 0.005 0.0417 0.1621
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Loa Loa (eye worm) hypothetical protein 0.0046 0.0379 0.1474
Schistosoma mansoni tubulin subunit beta 0.0057 0.0494 0.0908
Onchocerca volvulus 0.0089 0.0864 1
Echinococcus granulosus tubulin alpha 0.013 0.1326 0.1259
Echinococcus multilocularis lysosomal alpha glucosidase 0.0155 0.16 0.1535
Schistosoma mansoni alpha tubulin 0.0182 0.1908 0.3985
Leishmania major beta tubulin 0.024 0.257 1
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0455 0.0382
Trypanosoma brucei alpha tubulin 0.0182 0.1908 0.7426
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.1015 0.395
Echinococcus multilocularis GPCR, family 2 0.0046 0.0379 0.0305
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0379 0.0305
Brugia malayi CXXC zinc finger family protein 0.003 0.0193 0.0753
Schistosoma mansoni hypothetical protein 0.0046 0.0379 0.0658
Onchocerca volvulus 0.0087 0.0835 0.9624
Loa Loa (eye worm) hypothetical protein 0.0156 0.1615 0.6284
Schistosoma mansoni hypothetical protein 0.0046 0.0379 0.0658
Brugia malayi tubulin alpha-2 chain 0.0182 0.1908 0.7426
Echinococcus granulosus alpha tubulin 0.0182 0.1908 0.1846
Schistosoma mansoni tyrosine kinase 0.0083 0.0789 0.1551
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0057 0.0494 0.1489
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0505 0.0933
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Trypanosoma brucei beta tubulin 0.013 0.1326 0.5159
Onchocerca volvulus 0.003 0.0193 0.1488
Echinococcus granulosus tubulin alpha chain 0.0182 0.1908 0.1846
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0505 1
Schistosoma mansoni alpha tubulin 0.0182 0.1908 0.3985
Echinococcus multilocularis tubulin alpha chain 0.0182 0.1908 0.1846
Schistosoma mansoni alpha glucosidase 0.0034 0.0242 0.0361
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Leishmania major beta tubulin 0.024 0.257 1
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Echinococcus multilocularis neuropeptide s receptor 0.0899 1 1
Echinococcus multilocularis muscleblind protein 0.0156 0.1615 0.1551
Leishmania major beta tubulin 0.024 0.257 1
Schistosoma mansoni hypothetical protein 0.0427 0.4674 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0455 0.1772
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0076 0.0296
Loa Loa (eye worm) hypothetical protein 0.0156 0.1615 0.6284
Brugia malayi Furin-like cysteine rich region family protein 0.0156 0.1612 0.6273
Giardia lamblia Delta tubulin 0.0057 0.0494 0.0181
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0034 0.0242 0.0943
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.013 0.1326 0.49
Echinococcus multilocularis protein dispatched 1 0.005 0.0423 0.035
Brugia malayi nuclear hormone receptor 0.002 0.0076 0.0296
Entamoeba histolytica tubulin family protein 0.024 0.257 1
Trypanosoma cruzi tubulin delta chain 0.0057 0.0494 0.1921
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.1513 0.1448
Brugia malayi Tubulin alpha chain 0.0057 0.0494 0.1921
Leishmania major beta tubulin 0.024 0.257 1
Trypanosoma brucei protein kinase, putative 0.0053 0.0455 0.1772
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Echinococcus multilocularis cpg binding protein 0.0032 0.0213 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0076 0.0296
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Schistosoma mansoni tubulin subunit gamma 0.013 0.1326 0.2718
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0131 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0455 0.0916
Trichomonas vaginalis tubulin epsilon chain, putative 0.024 0.257 1
Leishmania major zeta tubulin, putative 0.0057 0.0494 0.1921
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0455 0.1332
Echinococcus multilocularis dnaJ subfamily B 0.0427 0.4674 0.4633
Trypanosoma cruzi zeta tubulin, putative 0.0057 0.0494 0.1921
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0379 0.0305
Schistosoma mansoni hypothetical protein 0.0054 0.0464 0.0844
Giardia lamblia Beta tubulin 0.024 0.257 1
Loa Loa (eye worm) tubulin alpha 2 0.0125 0.127 0.4941
Trypanosoma cruzi beta tubulin, putative 0.024 0.257 1
Echinococcus granulosus tubulin subunit beta 0.024 0.257 0.2513
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0131 0.0508
Trypanosoma brucei zeta tubulin 0.0057 0.0494 0.1921
Trichomonas vaginalis tubulin epsilon chain, putative 0.0182 0.1908 0.7158
Schistosoma mansoni tubulin subunit beta 0.024 0.257 0.5424
Giardia lamblia Epsilon tubulin 0.0057 0.0494 0.0181
Brugia malayi Tubulin alpha-2 chain 0.0182 0.1908 0.7426
Echinococcus granulosus insulin growth factor 1 receptor beta 0.005 0.0417 0.0343
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0058 0.0505 0.0432
Schistosoma mansoni tubulin subunit beta 0.024 0.257 0.5424
Loa Loa (eye worm) hypothetical protein 0.0147 0.151 0.5876
Trichomonas vaginalis tubulin epsilon chain, putative 0.0057 0.0494 0.108
Echinococcus granulosus tubulin epsilon chain 0.013 0.1326 0.1259
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0076 0.0296
Trypanosoma cruzi tubulin gamma chain 0.013 0.1326 0.5159
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0455 0.1772
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0076 0.0296
Echinococcus granulosus dnaJ subfamily B 0.0427 0.4674 0.4633
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0074 0.0687 0.1912
Toxoplasma gondii beta tubulin 0.024 0.257 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0058 0.0505 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0494 0.108
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0034 0.0242 0.0458
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0131 0.2584
Echinococcus multilocularis tubulin alpha chain 0.0182 0.1908 0.1846
Schistosoma mansoni patched 1 0.0044 0.0353 0.0602
Echinococcus multilocularis Tubulin beta 2C chain 0.024 0.257 0.2513
Treponema pallidum cell division protein FtsZ 0.0057 0.0494 1
Leishmania major beta tubulin 0.024 0.257 1
Brugia malayi Tubulin alpha-2 chain 0.0182 0.1908 0.7426
Loa Loa (eye worm) tubulin gamma chain 0.013 0.1326 0.5159
Schistosoma mansoni hypothetical protein 0.01 0.0987 0.198
Echinococcus multilocularis beta tubulin 0.024 0.257 0.2513
Echinococcus granulosus neutral alpha glucosidase AB 0.0034 0.0242 0.0167
Mycobacterium leprae cell division protein FtsZ 0.0057 0.0494 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0076 0.0296
Schistosoma mansoni tyrosine kinase 0.005 0.0417 0.074
Giardia lamblia Beta tubulin 0.024 0.257 1
Echinococcus granulosus tubulin alpha 1C chain 0.0182 0.1908 0.1846
Schistosoma mansoni tubulin subunit beta 0.024 0.257 0.5424
Echinococcus multilocularis protein patched 0.0044 0.0353 0.0279
Giardia lamblia Alpha-tubulin 0.0182 0.1908 0.6872
Loa Loa (eye worm) alpha-tubulin 0.0182 0.1908 0.7426
Echinococcus multilocularis 0.0048 0.0399 0.0325
Toxoplasma gondii alpha tubulin TUBA1 0.0182 0.1908 0.7288
Loa Loa (eye worm) tubulin beta-2A chain 0.024 0.257 1
Schistosoma mansoni cpg binding protein 0.0032 0.0213 0.0297
Brugia malayi beta-tubulin, identical 0.024 0.257 1
Schistosoma mansoni tyrosine kinase 0.0083 0.0789 0.1551
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.1908 0.1846
Trypanosoma brucei alpha tubulin 0.0182 0.1908 0.7426
Mycobacterium tuberculosis Cell division protein FtsZ 0.0057 0.0494 0.9689
Echinococcus multilocularis tubulin alpha chain 0.0182 0.1908 0.1846
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0455 0.0825
Plasmodium vivax tubulin alpha chain, putative 0.0182 0.1908 0.7288
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0455 0.1772
Echinococcus multilocularis tubulin alpha 3 chain 0.0182 0.1908 0.1846
Leishmania major epsilon tubulin, putative 0.013 0.1326 0.5159
Loa Loa (eye worm) BEN-1 protein 0.024 0.257 1
Echinococcus granulosus tubulin alpha 3 chain 0.0182 0.1908 0.1846
Leishmania major beta tubulin 0.024 0.257 1
Echinococcus multilocularis beta tubulin 0.024 0.257 0.2513
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Echinococcus multilocularis tubulin alpha 1C chain 0.0182 0.1908 0.1846
Schistosoma mansoni hypothetical protein 0.0177 0.1852 0.3861
Loa Loa (eye worm) hypothetical protein 0.0103 0.1015 0.395
Echinococcus multilocularis Tubulin beta 2C chain 0.024 0.257 0.2513
Brugia malayi MAP kinase sur-1 0.0053 0.0455 0.1772
Echinococcus granulosus tubulin alpha chain 0.0182 0.1908 0.1846
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0125 0.127 0.4414
Loa Loa (eye worm) hypothetical protein 0.0087 0.0835 0.3248
Echinococcus granulosus Tubulin beta 2C chain 0.024 0.257 0.2513
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0076 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0242 0.0943
Echinococcus multilocularis neuropeptide receptor A26 0.0899 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0455 0.0916
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0076 0.0296
Mycobacterium ulcerans aldehyde dehydrogenase 0.0058 0.0505 1
Leishmania major gamma-tubulin 0.013 0.1326 0.5159
Trichomonas vaginalis tubulin alpha chain, putative 0.013 0.1326 0.4656
Brugia malayi CHE-14 protein 0.0044 0.0353 0.1373
Echinococcus multilocularis tubulin alpha 3 chain 0.0182 0.1908 0.1846
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0076 0.0296
Trichomonas vaginalis tubulin, putative 0.0074 0.0687 0.1912
Echinococcus multilocularis hypothetical protein 0.0182 0.1908 0.1846
Leishmania major beta tubulin 0.024 0.257 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0076 0.0296
Trichomonas vaginalis tubulin beta chain, putative 0.0074 0.0687 0.1912
Brugia malayi Tubulin gamma chain 0.013 0.1326 0.5159
Entamoeba histolytica tubulin alpha-1 chain 0.0182 0.1908 0.7288
Trypanosoma brucei beta tubulin 0.024 0.257 1
Schistosoma mansoni aldehyde dehydrogenase 0.0058 0.0505 0.0933
Echinococcus granulosus lysosomal alpha glucosidase 0.0155 0.16 0.1535
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0573 0.108
Loa Loa (eye worm) tubulin alpha 2 0.0125 0.127 0.4941
Loa Loa (eye worm) tubulin alpha-3 chain 0.0108 0.1076 0.4188
Echinococcus granulosus tubulin alpha 3 chain 0.0182 0.1908 0.1846
Echinococcus granulosus Tubulin beta 2C chain 0.024 0.257 0.2513
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0193 0.0753
Echinococcus granulosus tubulin gamma 1 chain 0.013 0.1326 0.1259
Leishmania major beta tubulin 0.024 0.257 1
Trichomonas vaginalis tubulin gamma chain, putative 0.013 0.1326 0.4656
Giardia lamblia Gamma tubulin 0.013 0.1326 0.4117
Echinococcus granulosus insulin receptor 0.005 0.0417 0.0343
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0076 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0076 0.0296
Plasmodium falciparum tubulin delta chain, putative 0.0057 0.0494 0.1489
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.1908 0.7158
Loa Loa (eye worm) tubulin alpha chain 0.0182 0.1908 0.7426
Leishmania major beta tubulin 0.024 0.257 1
Loa Loa (eye worm) tubulin alpha 2 0.0052 0.0438 0.1703
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.005 0.0417 0.0343
Schistosoma mansoni tyrosine kinase 0.0084 0.0799 0.1572
Brugia malayi ecdysteroid receptor 0.002 0.0076 0.0296
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.1513 0.1448
Trypanosoma brucei epsilon tubulin 0.013 0.1326 0.5159
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.1015 0.3626
Brugia malayi Cell division protein ftsZ 0.0057 0.0494 0.1921
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0108 0.1076 0.3583
Trichomonas vaginalis tubulin alpha chain, putative 0.024 0.257 1
Plasmodium falciparum tubulin gamma chain 0.013 0.1326 0.49
Echinococcus multilocularis insulin receptor 0.005 0.0417 0.0343
Loa Loa (eye worm) hypothetical protein 0.0108 0.1076 0.4188
Leishmania major delta tubulin, putative 0.0057 0.0494 0.1921
Echinococcus granulosus Tubulin alpha 1 chain 0.0182 0.1908 0.1846
Entamoeba histolytica tubulin family protein 0.024 0.257 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0034 0.0242 0.0943
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.1908 0.7158
Echinococcus granulosus expressed conserved protein 0.0097 0.0945 0.0875
Echinococcus granulosus tubulin beta 1 chain 0.024 0.257 0.2513
Loa Loa (eye worm) hypothetical protein 0.0182 0.1908 0.7426
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0131 0.2584
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0835 0.165
Echinococcus multilocularis tubulin alpha 0.013 0.1326 0.1259
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.1612 0.1548
Loa Loa (eye worm) alpha-tubulin 0.0182 0.1908 0.7426
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0455 0.0382
Brugia malayi Tubulin beta-1 chain 0.024 0.257 1
Schistosoma mansoni hypothetical protein 0.0046 0.0379 0.0658
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Trypanosoma cruzi alpha tubulin, putative 0.0182 0.1908 0.7426
Leishmania major beta tubulin 0.024 0.257 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0379 0.0305
Trypanosoma brucei zeta tubulin, putative 0.0057 0.0494 0.1921
Plasmodium vivax tubulin beta chain, putative 0.024 0.257 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0353 0.1373
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.1908 0.7158
Plasmodium falciparum alpha tubulin 2 0.0182 0.1908 0.7288
Echinococcus granulosus geminin 0.0177 0.1852 0.1789
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0242 0.0458
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0353 0.0279
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0455 0.0916
Leishmania major alpha glucosidase II subunit, putative 0.0034 0.0242 0.0943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0076 0.0296
Loa Loa (eye worm) beta-tubulin 0.024 0.257 1
Echinococcus granulosus tubulin alpha 1C chain 0.0182 0.1908 0.1846
Echinococcus granulosus tubulin beta 4A class IVa 0.024 0.257 0.2513
Schistosoma mansoni alpha tubulin 0.0182 0.1908 0.3985
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.1612 0.1548
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.1908 0.1846
Echinococcus granulosus tubulin delta chain 0.0057 0.0494 0.0421
Trypanosoma brucei beta tubulin 0.024 0.257 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0455 0.1772
Plasmodium vivax tubulin alpha chain, putative 0.0182 0.1908 0.7288
Echinococcus multilocularis Tubulin beta 2C chain 0.024 0.257 0.2513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0076 0.0296
Leishmania major beta tubulin 0.024 0.257 1
Trypanosoma brucei alpha tubulin 0.0182 0.1908 0.7426
Brugia malayi Glycosyl hydrolases family 31 protein 0.0155 0.16 0.6226
Toxoplasma gondii aldehyde dehydrogenase 0.0058 0.0505 0.1536
Echinococcus multilocularis tubulin subunit TubB 0.0182 0.1908 0.1846
Trichomonas vaginalis tubulin alpha chain, putative 0.0074 0.0687 0.1912
Trichomonas vaginalis tubulin gamma chain, putative 0.013 0.1326 0.4656
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.1908 0.1846
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0835 0.3248
Brugia malayi latrophilin 2 splice variant baaae 0.01 0.0987 0.3839
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0455 0.1772
Leishmania major beta tubulin 0.024 0.257 1
Plasmodium vivax delta tubulin, putative 0.0057 0.0494 0.1489
Brugia malayi alpha-tubulin 0.0182 0.1908 0.7426
Echinococcus granulosus beta tubulin 0.024 0.257 0.2513
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0076 0.0296
Schistosoma mansoni tubulin subunit alpha 0.0182 0.1908 0.3985
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0379 0.1474
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0799 0.0729
Leishmania major beta tubulin 0.024 0.257 1
Schistosoma mansoni tyrosine kinase 0.0083 0.0789 0.1551
Echinococcus multilocularis tubulin alpha chain 0.0182 0.1908 0.1846
Echinococcus multilocularis geminin 0.0177 0.1852 0.1789
Echinococcus granulosus Tubulin beta 2C chain 0.024 0.257 0.2513
Brugia malayi nuclear receptor NHR-88 0.002 0.0076 0.0296
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0057 0.0494 1
Schistosoma mansoni tubulin subunit alpha 0.0182 0.1908 0.3985
Leishmania major beta tubulin 0.024 0.257 1
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Echinococcus granulosus Tubulin beta 2C chain 0.024 0.257 0.2513
Brugia malayi Tubulin alpha chain 0.0182 0.1908 0.7426
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0494 0.108
Echinococcus multilocularis Tubulin alpha 1 chain 0.0182 0.1908 0.1846
Loa Loa (eye worm) hypothetical protein 0.002 0.0076 0.0296
Trypanosoma cruzi epsilon tubulin, putative 0.013 0.1326 0.5159
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0076 0.0296
Brugia malayi Tubulin beta chain 0.0057 0.0494 0.1921
Trypanosoma cruzi zeta tubulin, putative 0.0057 0.0494 0.1921
Schistosoma mansoni tubulin subunit delta 0.0057 0.0494 0.0908
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0379 0.1474
Brugia malayi Muscleblind-like protein 0.0156 0.1615 0.6284
Entamoeba histolytica tubulin alpha chain, putative 0.0182 0.1908 0.7288
Trichomonas vaginalis tubulin, putative 0.0057 0.0494 0.108
Loa Loa (eye worm) tubulin beta-4 chain 0.024 0.257 1
Echinococcus granulosus tubulin alpha chain 0.0182 0.1908 0.1846
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0058 0.0505 0.0432
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0455 0.0382
Echinococcus granulosus cpg binding protein 0.0032 0.0213 0.0138
Echinococcus granulosus tubulin alpha chain 0.0182 0.1908 0.1846
Schistosoma mansoni cpg binding protein 0.0032 0.0213 0.0297
Schistosoma mansoni hypothetical protein 0.0046 0.0379 0.0658
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0131 0.0508
Schistosoma mansoni hypothetical protein 0.0042 0.0335 0.0563
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0835 0.0764
Echinococcus multilocularis lysosomal alpha glucosidase 0.0155 0.16 0.1535
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0353 0.0475
Plasmodium falciparum tubulin beta chain 0.024 0.257 1
Toxoplasma gondii alpha-tubulin I, putative 0.0182 0.1908 0.7288
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0455 0.1772
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.1015 0.0946
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0455 0.0916
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0242 0.0458
Leishmania major alpha tubulin 0.0182 0.1908 0.7426
Trichomonas vaginalis tubulin beta chain, putative 0.0182 0.1908 0.7158
Loa Loa (eye worm) hypothetical protein 0.0054 0.0465 0.1809
Brugia malayi tubulin alpha chain - mouse 0.0182 0.1908 0.7426
Echinococcus multilocularis tubulin alpha chain 0.0182 0.1908 0.1846
Schistosoma mansoni alpha-glucosidase 0.0133 0.1357 0.2786
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0379 0.0305
Echinococcus granulosus Tubulin beta 2C chain 0.024 0.257 0.2513
Loa Loa (eye worm) BEN-1 protein 0.024 0.257 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) uM Inhibitory activity against human methionine aminopeptidase-1; NT = Not tested ChEMBL. 15012983
IC50 (binding) 0 uM Inhibitory activity against human methionine aminopeptidase-1; NT = Not tested ChEMBL. 15012983
IC50 (binding) = 51 uM Inhibitory activity against human methionine aminopeptidase-2 ChEMBL. 15012983
IC50 (binding) = 51 uM Inhibitory activity against human methionine aminopeptidase-2 ChEMBL. 15012983

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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