Detailed information for compound 301809

Basic information

Technical information
  • TDR Targets ID: 301809
  • Name: (2S)-2-amino-N-dodecyl-3-methoxypropanamide
  • MW: 286.453 | Formula: C16H34N2O2
  • H donors: 2 H acceptors: 1 LogP: 4.1 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCNC(=O)[C@H](COC)N
  • InChi: 1S/C16H34N2O2/c1-3-4-5-6-7-8-9-10-11-12-13-18-16(19)15(17)14-20-2/h15H,3-14,17H2,1-2H3,(H,18,19)/t15-/m0/s1
  • InChiKey: ZOIBDVACCGCQAE-HNNXBMFYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-amino-N-dodecyl-3-methoxy-propanamide
  • (2S)-2-azanyl-N-dodecyl-3-methoxy-propanamide
  • (2S)-2-amino-N-lauryl-3-methoxy-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0407 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0053
Trypanosoma brucei metacaspase MCA2 0.0054 0.0658 0.7892
Onchocerca volvulus 0.0012 0.0047 0.0129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.013
Echinococcus granulosus lamin 0.0027 0.0275 0.0275
Echinococcus granulosus dna polymerase eta 0.0046 0.0536 0.0536
Echinococcus multilocularis cpg binding protein 0.0031 0.0324 0.0324
Schistosoma mansoni intermediate filament proteins 0.0027 0.0275 0.0275
Schistosoma mansoni heat shock protein 0.0066 0.0833 0.0833
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0053 0.0638 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0111 0.1299
Brugia malayi heat shock protein 90 0.0066 0.0833 0.1806
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0464 0.1372
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0003 0.0003
Schistosoma mansoni endoplasmin 0.0066 0.0833 0.0833
Echinococcus granulosus heat shock protein 90 0.0066 0.0833 0.0833
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.2941 0.6396
Brugia malayi tumor suppressor. 0.0327 0.4596 1
Plasmodium vivax metacaspase 1, putative 0.0054 0.0658 0.7892
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0013 0.007 0.0146
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0073 0.0846
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0638 0.1891
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus multilocularis caspase 8 0.0054 0.0658 0.0658
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0162 0.2504
Trichomonas vaginalis rotamase, putative 0.0034 0.0369 0.1089
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0027 0.0072
Plasmodium vivax heat shock protein 90, putative 0.0027 0.027 0.3215
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0326 0.0326
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0162 0.1918
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0658 0.1949
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0027 0.0027
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0073 0.1105
Brugia malayi Endoplasmin precursor 0.0066 0.0833 0.1806
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0073 0.0153
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0369 0.0797
Onchocerca volvulus 0.0012 0.0047 0.0129
Giardia lamblia Heat shock protein HSP 90-alpha 0.0066 0.0833 1
Schistosoma mansoni microtubule-associated protein tau 0.0702 1 1
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.001 0.0028 0.0301
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.027 0.027
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0073 0.0073
Echinococcus multilocularis heat shock protein 90 0.0053 0.0638 0.0638
Plasmodium vivax DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Echinococcus multilocularis caspase 3 0.0148 0.2012 0.2012
Brugia malayi nuclear receptor NHR-88 0.001 0.0027 0.0053
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0275 0.0591
Echinococcus multilocularis dna polymerase kappa 0.002 0.0162 0.0162
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0358 0.4273
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0028 0.0301
Leishmania major heat shock protein, putative 0.0027 0.027 0.2608
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0162 0.0474
Brugia malayi CXXC zinc finger family protein 0.0029 0.03 0.0647
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0003 0.0003
Echinococcus granulosus caspase 2 0.0054 0.0658 0.0658
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Brugia malayi ecdysteroid receptor 0.001 0.0027 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Brugia malayi hypothetical protein 0.009 0.1172 0.2544
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.03 0.0647
Loa Loa (eye worm) tumor suppressor 0.0327 0.4596 1
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0326 0.0326
Giardia lamblia DINP protein human, muc B family 0.002 0.0162 0.1918
Echinococcus multilocularis protein quaking 0.0028 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Schistosoma mansoni coup transcription factor 0.001 0.0027 0.0027
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0027 0.0027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0027 0.0027
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0073 0.1105
Mycobacterium tuberculosis Conserved protein 0.0013 0.0073 0.1105
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0013 0.0073 0.0846
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0162 0.2504
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0162 0.1918
Trypanosoma brucei developmentally regulated phosphoprotein 0.0013 0.0073 0.0846
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0073 0.0846
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0053
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0027 0.0027
Schistosoma mansoni cpg binding protein 0.0029 0.03 0.03
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0153
Brugia malayi kinase, mitochondrial precursor 0.0013 0.0073 0.0153
Leishmania major calcium channel protein, putative,ion transporter, putative 0.008 0.1026 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Trypanosoma brucei metacaspase 0.0054 0.0658 0.7892
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0693 0.8321
Trypanosoma cruzi metacaspase, putative 0.0054 0.0658 0.7892
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0027 0.0027
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0003 0.0003
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0003 0.0003
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Loa Loa (eye worm) heat shock protein 90 0.0066 0.0833 0.1806
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0073 0.0846
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0073 0.0073
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0027 0.0072
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0073 0.1105
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.0833 1
Echinococcus multilocularis microtubule associated protein 2 0.0702 1 1
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0073 0.1105
Schistosoma mansoni lamin 0.0027 0.0275 0.0275
Leishmania major DNA polymerase kappa, putative 0.002 0.0162 0.1556
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0162 0.0162
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0027 0.0027
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0073 0.1105
Brugia malayi Hsp90 protein 0.0027 0.027 0.0581
Brugia malayi hypothetical protein 0.0241 0.3347 0.7282
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0407 0.0407
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0028 0.0278 0.0599
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0073 0.1105
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.3347 0.3347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0053
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.027 0.3215
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0833 1
Echinococcus granulosus caspase 0.0202 0.2791 0.2791
Trypanosoma cruzi metacaspase, putative 0.0054 0.0658 0.7892
Loa Loa (eye worm) histone methyltransferase 0.001 0.0026 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0162 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0074 0.0859
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0073 0.0073
Giardia lamblia Pms1-like protein 0.0013 0.0073 0.0846
Leishmania major metacaspase, putative 0.0054 0.0658 0.6401
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0658 0.7892
Schistosoma mansoni nuclear hormone receptor 0.001 0.0027 0.0027
Brugia malayi Pre-SET motif family protein 0.0212 0.2941 0.6396
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Onchocerca volvulus 0.0031 0.0326 0.0962
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.001 0.0028 0.0301
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0073 0.0846
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0053
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0027 0.0027
Trypanosoma cruzi heat shock protein 85, putative 0.0053 0.0638 0.7659
Trypanosoma brucei unspecified product 0.002 0.0162 0.1918
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.009 0.1172 0.2544
Toxoplasma gondii heat shock protein 90, putative 0.0066 0.0833 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0073 0.1105
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0833 1
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.008 0.1026 0.1026
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0003 0.0003
Echinococcus multilocularis lamin dm0 0.0027 0.0275 0.0275
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0536 0.6422
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0073 0.0687
Brugia malayi Pre-SET motif family protein 0.0031 0.0326 0.0703
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0789 0.0789
Onchocerca volvulus 0.0012 0.0047 0.0129
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0073 0.0153
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0638 0.1891
Brugia malayi hypothetical protein 0.0028 0.0278 0.0599
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0073 0.0209
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0027 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0341 0.4069
Echinococcus multilocularis enteropeptidase 0.0012 0.0047 0.0047
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0012 0.0047 0.0095
Schistosoma mansoni hypothetical protein 0.0416 0.5878 0.5878
Schistosoma mansoni hypothetical protein 0.0028 0.0278 0.0278
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0003 0.0003
Echinococcus multilocularis tumor protein p63 0.0344 0.4835 0.4835
Trypanosoma brucei Metacaspase-4 0.0054 0.0658 0.7892
Echinococcus multilocularis transmembrane protease serine 3 0.0012 0.0047 0.0047
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0073 0.1105
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0013 0.0073 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Trypanosoma cruzi heat shock protein 90, putative 0.0066 0.0833 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0073 0.1105
Brugia malayi nuclear hormone receptor 0.001 0.0027 0.0053
Brugia malayi Trypsin family protein 0.0012 0.0047 0.0095
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus granulosus caspase 3 0.0148 0.2012 0.2012
Entamoeba histolytica hypothetical protein 0.0037 0.0407 0.4867
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0202 0.2791 0.2791
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.0833 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0073 0.0846
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0053
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0073 0.0846
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0111 0.1299
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0027 0.0027
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0.0073 1
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0013 0.0073 0.0209
Schistosoma mansoni heat shock protein 0.0027 0.027 0.027
Echinococcus granulosus dnaJ subfamily B 0.0416 0.5878 0.5878
Brugia malayi hypothetical protein 0.0012 0.0047 0.0095
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Onchocerca volvulus 0.0027 0.0275 0.0808
Loa Loa (eye worm) trypsin family protein 0.0012 0.0047 0.0095
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0003 0.0003
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0073 0.0209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.3347 0.3347
Treponema pallidum heat shock protein 90 0.0053 0.0638 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0027 0.0027
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0027 0.0053
Plasmodium falciparum heat shock protein 90 0.0066 0.0833 1
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0833 0.2469
Echinococcus multilocularis endoplasmin 0.0053 0.0638 0.0638
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0003 0.0003
Echinococcus multilocularis dna polymerase eta 0.0046 0.0536 0.0536
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0027 0.0053
Echinococcus multilocularis Mastin 0.0012 0.0047 0.0047
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0013 0.0073 0.0073
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0073 0.1105
Plasmodium falciparum endoplasmin, putative 0.0041 0.0464 0.5556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0053
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0073 0.1105
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0049 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0111 0.0235
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0111 0.1696
Entamoeba histolytica heat shock protein 90, putative 0.0066 0.0833 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0202 0.2791 0.2791
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0162 0.1918
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0073 1
Loa Loa (eye worm) hypothetical protein 0.0241 0.3347 0.7282
Plasmodium vivax endoplasmin, putative 0.0066 0.0833 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0073 0.1105
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0111 0.1299
Loa Loa (eye worm) hypothetical protein 0.0027 0.0268 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0658 0.1949
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0407 0.0407
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0053 0.0638 0.6212
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Schistosoma mansoni endoplasmin 0.0066 0.0833 0.0833
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0091 0.0191
Leishmania major DNA polymerase eta, putative 0.0032 0.0341 0.33
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0013 0.0073 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0658 0.1949
Brugia malayi intermediate filament protein 0.0027 0.0275 0.0591
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.027 0.3215
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0369 0.1089
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0111 0.1299
Schistosoma mansoni survival motor neuron protein 0.0049 0.0587 0.0587
Echinococcus multilocularis expressed protein 0.0034 0.0369 0.0369
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trichomonas vaginalis endoplasmin, putative 0.0041 0.0464 0.1372
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0658 0.1425
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Brugia malayi isocitrate dehydrogenase 0.0016 0.0111 0.0235
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0658 0.7892
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0658 0.1949
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0091 0.0191
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.027 0.3215
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0027 0.0027
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Plasmodium falciparum DNA topoisomerase 2 0.0013 0.0073 0.0846
Entamoeba histolytica hypothetical protein 0.0037 0.0407 0.4867
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0053
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0369 0.0797
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0012 0.0047 0.0047
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0073 0.1105
Schistosoma mansoni caspase-7 (C14 family) 0.0202 0.2791 0.2791
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0442 0.529
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Trypanosoma cruzi metacaspase, putative 0.0054 0.0658 0.7892
Onchocerca volvulus 0.0027 0.0275 0.0808
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0326 0.0326
Echinococcus multilocularis musashi 0.0027 0.0275 0.0275
Chlamydia trachomatis DNA gyrase subunit B 0.0013 0.0073 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Echinococcus granulosus heat shock protein 0.0066 0.0833 0.0833
Giardia lamblia Grp94/Hsp90 0.0053 0.0638 0.7659
Leishmania major developmentally regulated phosphoprotein-like protein 0.0013 0.0073 0.0687
Leishmania major hypothetical protein, conserved 0.0013 0.0073 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0053
Brugia malayi Cell death protein 3 precursor 0.0054 0.0658 0.1425
Entamoeba histolytica hypothetical protein 0.0037 0.0407 0.4867
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0326 0.0326
Mycobacterium ulcerans hypothetical protein 0.0012 0.0047 0.0684
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0073 0.1105
Trichomonas vaginalis DNA topoisomerase II, putative 0.0013 0.0073 0.0209
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0073 0.0741
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0012 0.0047 0.0047
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Echinococcus multilocularis caspase 0.0202 0.2791 0.2791
Trypanosoma brucei unspecified product 0.0014 0.0074 0.0859
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Schistosoma mansoni rotamase 0.0034 0.0369 0.0369
Echinococcus granulosus expressed protein 0.0034 0.0369 0.0369
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0053
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0326 0.0326
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0073 0.1105
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0027 0.0027
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Trichomonas vaginalis rotamase, putative 0.0033 0.0358 0.1055
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0073 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0658 0.1949
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0029 0.03 0.0885
Onchocerca volvulus 0.0049 0.0587 0.1737
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Schistosoma mansoni cpg binding protein 0.0031 0.0324 0.0324
Plasmodium vivax heat shock protein, putative 0.0027 0.027 0.3215
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0053
Mycobacterium ulcerans heat shock protein 90 0.0053 0.0638 1
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.027 0.3215
Onchocerca volvulus Cell death protein 3 homolog 0.0054 0.0658 0.1949
Schistosoma mansoni lamin 0.0027 0.0275 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0027 0.0053
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0054 0.0658 0.0658
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0162 0.2504
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0658 0.7892
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0111 0.1299
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0358 0.4273
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Trichomonas vaginalis sensor histidine kinase, putative 0.0013 0.0073 0.0209
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0027
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0028 0.0244
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0162 0.1918
Giardia lamblia Heat shock protein HSP 90-alpha 0.0053 0.0638 0.7659
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0027 0.0053
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0073 0.0209
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0111 0.1299
Schistosoma mansoni hypothetical protein 0.0028 0.0278 0.0278
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0073 0.1105
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0054 0.0658 0.7892
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0054 0.0658 0.1425
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Echinococcus granulosus enteropeptidase 0.0012 0.0047 0.0047
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0027
Echinococcus granulosus cpg binding protein 0.0031 0.0324 0.0324
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.5878 0.5878
Echinococcus granulosus sodium channel protein 0.008 0.1026 0.1026
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0162 0.1556
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0162 0.1918
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Echinococcus granulosus protein quaking 0.0028 0.0278 0.0278
Loa Loa (eye worm) endoplasmin 0.0066 0.0833 0.1806
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0073 0.0073
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0073 0.1105
Onchocerca volvulus 0.0242 0.3362 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0053
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0053 0.0638 0.0638
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.001 0.0028 0.0301
Plasmodium falciparum DNA gyrase subunit B 0.0013 0.0073 0.0846
Onchocerca volvulus 0.0012 0.0047 0.0129
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0013 0.0073 0.0209
Echinococcus granulosus glycoprotein Antigen 5 0.0012 0.0047 0.0047
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0073 0.0846
Onchocerca volvulus 0.0012 0.0047 0.0129
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0326 0.0326
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0358 0.4273
Schistosoma mansoni cpg binding protein 0.0031 0.0324 0.0324
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0162 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0053
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0162 0.1918
Entamoeba histolytica hypothetical protein 0.0037 0.0407 0.4867
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0026 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0074 0.0859
Mycobacterium ulcerans putative regultory protein 0.0013 0.0073 0.1105
Echinococcus granulosus tumor protein p63 0.0344 0.4835 0.4835
Entamoeba histolytica DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.027 0.0794
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0024 0.0045
Trypanosoma cruzi metacaspase 5, putative 0.0054 0.0658 0.7892
Brugia malayi steroid hormone receptor 0.001 0.0027 0.0053
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0053 0.0638 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0111 0.0111
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0027 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0658 0.7892
Trypanosoma cruzi metacaspase, putative 0.0054 0.0658 0.7892
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Trypanosoma brucei heat shock protein 90, putative 0.0066 0.0833 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0358 0.4273
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0153
Echinococcus multilocularis heat shock protein 90 0.0066 0.0833 0.0833
Schistosoma mansoni DNA polymerase eta 0.0046 0.0536 0.0536
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0053
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0003 0.0003
Trypanosoma brucei metacaspase 5, putative 0.0054 0.0658 0.7892
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0027 0.0053
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0027 0.0027
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0587 0.127
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.027 0.3215
Plasmodium vivax heat shock protein 86, putative 0.0066 0.0833 1
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0003 0.0003
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Echinococcus granulosus endoplasmin 0.0053 0.0638 0.0638
Schistosoma mansoni heat shock protein 0.0066 0.0833 0.0833
Onchocerca volvulus 0.0012 0.0047 0.0129
Loa Loa (eye worm) hypothetical protein 0.009 0.1172 0.2544
Echinococcus granulosus dna polymerase kappa 0.002 0.0162 0.0162
Trypanosoma cruzi heat shock protein, putative 0.0027 0.027 0.3215
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0073 0.0846
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0012 0.0047 0.0047
Trypanosoma cruzi Heat shock protein 83, putative 0.0066 0.0833 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Echinococcus granulosus heat shock protein 90 0.0053 0.0638 0.0638
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0053
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0053 0.0638 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0111 0.0111
Echinococcus multilocularis heat shock protein 0.0066 0.0833 0.0833
Schistosoma mansoni hypothetical protein 0.0012 0.0047 0.0047
Brugia malayi Trypsin family protein 0.0012 0.0047 0.0095
Schistosoma mansoni ATPase 0.0009 0.0003 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.0053 0.0638 0.7659
Loa Loa (eye worm) heat shock protein 75 0.0027 0.027 0.0581
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Loa Loa (eye worm) hypothetical protein 0.0013 0.0073 0.0153
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0301 0.0301
Schistosoma mansoni thyroid hormone receptor 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0278 0.0599
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0111 0.0235
Leishmania major DNA topoisomerase ii 0.0013 0.0073 0.0687
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0073 0.1105
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0003 0.0003
Trichomonas vaginalis receptor histidine kinase, putative 0.0013 0.0073 0.0209
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0073 0.1105
Echinococcus granulosus caspase 8 0.0054 0.0658 0.0658
Trichomonas vaginalis set domain proteins, putative 0.0242 0.3362 1
Schistosoma mansoni hypothetical protein 0.0012 0.0047 0.0047
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0073 0.0153
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0162 0.0346
Loa Loa (eye worm) hypothetical protein 0.005 0.0605 0.1309
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0053
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0638 0.1891
Plasmodium vivax SET domain protein, putative 0.0031 0.0326 0.3895
Echinococcus granulosus Mastin 0.0012 0.0047 0.0047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0326 0.0326
Echinococcus multilocularis caspase 2 0.0054 0.0658 0.0658
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0003 0.0003
Echinococcus granulosus FTZ F1 alpha 0.001 0.0027 0.0027
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0003 0.0003
Schistosoma mansoni caspase-3 (C14 family) 0.0202 0.2791 0.2791
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0275 0.0591
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0111 0.1299
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0053
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0013 0.0073 0.0209
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0111 0.0111
Plasmodium vivax DNA gyrase subunit B, putative 0.0013 0.0073 0.0846
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0073 0.0153
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0275 0.0591
Brugia malayi hypothetical protein 0.0037 0.0407 0.0879
Onchocerca volvulus 0.005 0.0605 0.179
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0073 0.1105
Schistosoma mansoni ATPase 0.0009 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0037 0.0407 0.0407
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0162 0.0474
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0658 0.1949
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.007 0.007
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0063 0.013
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0003 0.0003
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0358 0.3465
Loa Loa (eye worm) hypothetical protein 0.0046 0.0536 0.116
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0536 0.116
Echinococcus multilocularis glycoprotein Antigen 5 0.0012 0.0047 0.0047
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0073 0.1105
Echinococcus multilocularis sodium channel protein 0.008 0.1026 0.1026
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0111 0.1054
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0003 0.0003
Trichomonas vaginalis heat shock protein, putative 0.0027 0.027 0.0794
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0326 0.3895
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0073 0.1105
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0073 0.1105
Loa Loa (eye worm) hypothetical protein 0.0054 0.0658 0.1425
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0073 0.1105
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.007 0.007
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0013 0.0073 0.0846
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0073 0.0741
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0111 0.0111
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0073 0.0846
Schistosoma mansoni eyes absent homolog 0.009 0.1172 0.1172
Leishmania major DNA polymerase eta, putative 0.0046 0.0536 0.5209
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0003 0.0003
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0162 0.2504
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0605 0.0605
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0013 0.0073 0.0209
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0073 0.1105
Plasmodium falciparum metacaspase 1 0.0054 0.0658 0.7892
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0341 0.4069
Schistosoma mansoni caspase-7 (C14 family) 0.0054 0.0658 0.0658
Trypanosoma brucei metacaspase MCA3 0.0054 0.0658 0.7892
Echinococcus granulosus hypothetical protein 0.0028 0.0278 0.0278
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0003 0.0003
Plasmodium falciparum metacaspase-like protein 0.0054 0.0658 0.7892
Schistosoma mansoni pyruvate dehydrogenase 0.0013 0.0073 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0054 0.0658 0.1949
Trypanosoma cruzi heat shock protein 85, putative 0.0066 0.0833 1
Toxoplasma gondii heat shock protein HSP90 0.0066 0.0833 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0162 0.1918
Schistosoma mansoni cercarial elastase (S01 family) 0.0012 0.0047 0.0047
Trypanosoma brucei Heat shock protein 83, putative 0.0066 0.0833 1
Trypanosoma brucei heat shock protein, putative 0.0066 0.0833 1
Trypanosoma brucei unspecified product 0.0014 0.0074 0.0859
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0012 0.0047 0.0047
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0003 0.0003
Echinococcus multilocularis lamin 0.0027 0.0275 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0162 0.1918
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.027 0.3215
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0162 0.0162
Leishmania major heat shock protein 83-1 0.0066 0.0833 0.8111
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0111 0.1299
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0095
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0073 0.1105
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0073 0.0741
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0162 0.1918
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0003 0.0003
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0013 0.0073 0.0209
Onchocerca volvulus 0.001 0.0027 0.0072
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0073 0.0846
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0012 0.0047 0.0047
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0003 0.0003
Brugia malayi Trypsin family protein 0.0012 0.0047 0.0095
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.027 0.027
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0073 0.1105
Brugia malayi Trypsin family protein 0.0012 0.0047 0.0095
Echinococcus granulosus transmembrane protease serine 3 0.0012 0.0047 0.0047
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0358 0.4273
Loa Loa (eye worm) hypothetical protein 0.0031 0.0326 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0074 0.0859
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0536 0.6422
Echinococcus granulosus lamin dm0 0.0027 0.0275 0.0275
Brugia malayi Trypsin-like protease protein 5 0.0012 0.0047 0.0095
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0073 0.1105
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0275 0.0591

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM Tested for inhibition of DNA synthesis at a dose range of 1.9-2.4 microg/ml after 30 min; range of 8-10 uM ChEMBL. No reference
pKa = 5.9 Dissociation constant of the compound was measured in water ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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