Detailed information for compound 317889

Basic information

Technical information
  • TDR Targets ID: 317889
  • Name: N-[9-[3,4-dihydroxy-5-(hydroxymethyl)-3-methy loxolan-2-yl]purin-6-yl]-N-hydroxypropanamide
  • MW: 353.331 | Formula: C14H19N5O6
  • H donors: 4 H acceptors: 8 LogP: -1.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1O)(C)O)n1cnc2c1ncnc2N(C(=O)CC)O
  • InChi: 1S/C14H19N5O6/c1-3-8(21)19(24)12-9-11(15-5-16-12)18(6-17-9)13-14(2,23)10(22)7(4-20)25-13/h5-7,10,13,20,22-24H,3-4H2,1-2H3
  • InChiKey: OCIHBUXSXFCWOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[9-[3,4-dihydroxy-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-2-yl]purin-6-yl]-N-hydroxy-propanamide
  • N-[9-[3,4-dihydroxy-5-(hydroxymethyl)-3-methyl-2-tetrahydrofuranyl]-6-purinyl]-N-hydroxypropanamide
  • N-[9-[3,4-dihydroxy-5-(hydroxymethyl)-3-methyl-oxolan-2-yl]purin-6-yl]-N-hydroxy-propanamide
  • N-[9-(3,4-dihydroxy-3-methyl-5-methylol-tetrahydrofuran-2-yl)purin-6-yl]-N-hydroxy-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0174 0.1703 0.3643
Schistosoma mansoni lipoxygenase 0.0096 0.087 0.1088
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.1071 0.1071
Schistosoma mansoni cathepsin F (C01 family) 0.0174 0.1703 0.2133
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0173 0.0582
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0337 0.0714
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0116 0.1086 0.2318
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0107 0.0221
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0173 0.0661
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Echinococcus multilocularis microtubule associated protein 2 0.0756 0.7971 0.7971
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0075 0.0152
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Schistosoma mansoni microtubule-associated protein tau 0.0756 0.7971 1
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Brugia malayi intermediate filament protein 0.0031 0.0175 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0057 0.0446 0.1494
Plasmodium vivax vivapain-2 0.0253 0.256 1
Giardia lamblia Cathepsin B precursor 0.0178 0.1754 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0397 0.4105 1
Brugia malayi Cathepsin L-like precursor 0.0174 0.1703 0.3638
Toxoplasma gondii exonuclease III APE 0.0022 0.0075 0.0278
Loa Loa (eye worm) ctsf protein 0.0253 0.256 0.5476
Onchocerca volvulus 0.0253 0.256 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Onchocerca volvulus 0.0253 0.256 1
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Trypanosoma cruzi cysteine peptidase, putative 0.008 0.0694 0.1477
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0173 0.0661
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0107 0.0304
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0446 0.0947
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.108 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.008 0.0694 0.1477
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0134 0.0318
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0561 0.0561
Brugia malayi Pre-SET motif family protein 0.0215 0.2147 0.4588
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0446 0.1494
Schistosoma mansoni rab6-interacting 0.0023 0.0084 0.0101
Echinococcus multilocularis lamin 0.0031 0.0175 0.0175
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.03 0.0905
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0253 0.256 0.256
Loa Loa (eye worm) hypothetical protein 0.0031 0.0169 0.0361
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Echinococcus granulosus lamin dm0 0.0031 0.0175 0.0219
Echinococcus granulosus cathepsin b 0.045 0.4675 0.5866
Brugia malayi Papain family cysteine protease containing protein 0.0253 0.256 0.5472
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.108 0.2623
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0366 0.046
Giardia lamblia Cathepsin B precursor 0.0178 0.1754 1
Toxoplasma gondii cathepsin B 0.0178 0.1754 0.6847
Plasmodium vivax unspecified product 0.008 0.0694 0.2539
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0057 0.0446 0.1548
Trypanosoma cruzi cruzipain precursor, putative 0.008 0.0694 0.1477
Brugia malayi Doublecortin family protein 0.0023 0.0084 0.0172
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.108 0.1351
Brugia malayi phosphofructokinase 0.0116 0.108 0.2303
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0138 0.1321 0.1657
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.1321 0.3212
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0075 0.0152
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.045 0.4675 0.5864
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0134 0.0279
Plasmodium falciparum serine repeat antigen 4 0.0057 0.0446 0.1548
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.108 0.1351
Plasmodium vivax vivapain-3 0.0136 0.1303 0.4974
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.1303 0.1631
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0057 0.0446 0.1548
Plasmodium falciparum serine repeat antigen 8 0.0057 0.0446 0.1548
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.108 0.2309
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1712 0.4165
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0446 0.0555
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0446 0.2211
Echinococcus multilocularis neuropeptide s receptor 0.0541 0.5653 0.5653
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.109 0.1363
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0178 0.1754 0.3747
Giardia lamblia Encystation-specific protease 0.0057 0.0446 0.2211
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0084 0.018
Schistosoma mansoni inositol monophosphatase 0.0043 0.03 0.0372
Mycobacterium ulcerans hypothetical protein 0.0174 0.1712 0.4165
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0107 0.0221
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0366 0.0784
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Echinococcus granulosus neuropeptide receptor A26 0.0541 0.5653 0.7092
Plasmodium falciparum serine repeat antigen 3 0.0057 0.0446 0.1548
Giardia lamblia Cathepsin L-like protease 0.0057 0.0446 0.2211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0018 0.003
Plasmodium falciparum serine repeat antigen 1 0.0057 0.0446 0.1548
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.108 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0884 0.0884
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0173 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0057 0.0446 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0446 0.0947
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.1071 0.1343
Loa Loa (eye worm) phosphofructokinase 0.0116 0.108 0.2309
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0057 0.0446 0.0555
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Brugia malayi MH2 domain containing protein 0.0127 0.1202 0.2565
Brugia malayi Inositol-1 0.0043 0.03 0.0634
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0175 0.0374
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0446 0.1494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus granulosus tar DNA binding protein 0.0067 0.0561 0.0704
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0884 0.1105
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0134 0.0384
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0331 0.3397 1
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0561 0.12
Schistosoma mansoni lipoxygenase 0.0137 0.1315 0.1646
Schistosoma mansoni lamin 0.0031 0.0175 0.0215
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.0691 0.1471
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Echinococcus multilocularis musashi 0.0031 0.0175 0.0175
Giardia lamblia Cathepsin L-like protease 0.0057 0.0446 0.2211
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.108 0.3171
Brugia malayi hypothetical protein 0.0023 0.0084 0.0172
Giardia lamblia Hypothetical protein 0.0057 0.0446 0.2211
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0884 0.1105
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0168 0.0211
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0173 0.0393
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0107 0.0229
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1522 0.3249
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0337 0.0983
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.03 0.0722
Echinococcus granulosus microtubule associated protein 2 0.0756 0.7971 1
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0447 0.0949
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0275 0.2797 0.5983
Leishmania major cysteine peptidase A (CPA) 0.0253 0.256 0.7535
Loa Loa (eye worm) hypothetical protein 0.0253 0.256 0.5476
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Schistosoma mansoni rab6-interacting 0.0023 0.0084 0.0101
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0446 0.0947
Schistosoma mansoni hypothetical protein 0.0042 0.0288 0.0357
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0134 0.0318
Brugia malayi 6-phosphofructokinase 0.0116 0.108 0.2303
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.1303 0.383
Loa Loa (eye worm) hypothetical protein 0.0174 0.1703 0.3643
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0446 0.1494
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Onchocerca volvulus 0.0031 0.0168 0.034
Echinococcus granulosus intermediate filament protein 0.0031 0.0175 0.0219
Onchocerca volvulus 0.0253 0.256 1
Brugia malayi cathepsin L precursor 0.0057 0.0446 0.0947
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.1321 0.3212
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0075 0.0173
Entamoeba histolytica cysteine proteinase 1, putative 0.0136 0.1303 0.4942
Loa Loa (eye worm) hypothetical protein 0.0031 0.0168 0.036
Schistosoma mansoni hypothetical protein 0.0079 0.0691 0.0863
Onchocerca volvulus 0.0253 0.256 1
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0134 0.0318
Plasmodium vivax SET domain protein, putative 0.0031 0.0168 0.0437
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0168 0.0207
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Trichomonas vaginalis set domain proteins, putative 0.0244 0.2466 0.9623
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.1522 0.4474
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0084 0.01
Plasmodium falciparum serine repeat antigen 2 0.0057 0.0446 0.1548
Onchocerca volvulus 0.0253 0.256 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0251 0.0604
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0168 0.0207
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.03 0.0905
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0168 0.0644
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0173 0.0393
Schistosoma mansoni ap endonuclease 0.0022 0.0075 0.0089
Toxoplasma gondii cathepsin CPC2 0.0057 0.0446 0.173
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0084 0.0105
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0057 0.0446 0.1548
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Brugia malayi fibroinase precursor 0.0057 0.0446 0.0947
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0075 0.0094
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0075 0.0173
Loa Loa (eye worm) hypothetical protein 0.0115 0.1071 0.229
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0287
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0173 0.0973
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0446 0.0954
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0075 0.0064
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1484
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0107 0.0252
Brugia malayi cathepsin Z-like cysteine proteinase 0.0057 0.0446 0.0947
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.1303 0.4942
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.108 0.3171
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0446 0.2211
Echinococcus multilocularis cathepsin b 0.045 0.4675 0.4675
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0134 0.1211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0075 0.021
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0107 0.0229
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0138 0.1321 0.3882
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0059 0.0135
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0018 0.0038
Toxoplasma gondii cathepsin CPC1 0.0057 0.0446 0.173
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0366 0.046
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0134 0.0318
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.018
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Schistosoma mansoni aldehyde dehydrogenase 0.0138 0.1321 0.1653
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0057 0.0446 0.2211
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.03 0.0905
Toxoplasma gondii cathepsin CPL 0.0253 0.256 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0175 0.0366
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0126
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1484
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Loa Loa (eye worm) hypothetical protein 0.008 0.0694 0.1484
Brugia malayi hypothetical protein 0.0042 0.0288 0.0608
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0057 0.0446 0.1548
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0884 0.1884
Toxoplasma gondii hypothetical protein 0.0053 0.0411 0.1593
Echinococcus multilocularis cathepsin L 0.0136 0.1303 0.1303
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0084 0.0084
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Brugia malayi Pre-SET motif family protein 0.0031 0.0168 0.0352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0884 0.1105
Brugia malayi RNA binding protein 0.0067 0.0561 0.1193
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus granulosus cathepsin L 0.0057 0.0446 0.056
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0232 0.0232
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Trypanosoma brucei cysteine peptidase C (CPC) 0.0178 0.1754 0.5159
Loa Loa (eye worm) hypothetical protein 0.0037 0.0232 0.0497
Loa Loa (eye worm) hypothetical protein 0.0174 0.1703 0.3643
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.1321 0.3212
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0287
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.1522 0.4474
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.03 0.1158
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.1303 0.2782
Brugia malayi cathepsin F-like cysteine proteinase 0.008 0.0694 0.1477
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Brugia malayi cathepsin F-like cysteine proteinase 0.0057 0.0446 0.0947
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0446 0.1548
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0134 0.0318
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0174 0.1703 0.3638
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0057 0.0446 0.1548
Onchocerca volvulus 0.0028 0.0134 0.0202
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0446 0.0947
Schistosoma mansoni loxhd1 0.0023 0.0084 0.0101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Schistosoma mansoni patched 1 0.0049 0.0366 0.0455
Schistosoma mansoni ap endonuclease 0.0022 0.0075 0.0089
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0057 0.0446 0.0555
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0107 0.0229
Plasmodium vivax unspecified product 0.0057 0.0446 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0084 0.0105
Trypanosoma cruzi cruzipain precursor, putative 0.0253 0.256 0.5472
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.03 0.0376
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.045 0.4675 0.5864
Onchocerca volvulus Cathepsin L homolog 0.0253 0.256 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.1071 0.4007
Loa Loa (eye worm) cathepsin B 0.0178 0.1754 0.3752
Loa Loa (eye worm) hypothetical protein 0.0079 0.0691 0.1478
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.108 0.4043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3397 0.7262
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0288 0.0361
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Loa Loa (eye worm) RNA binding protein 0.0067 0.0561 0.12
Brugia malayi cathepsin L-like cysteine proteinase 0.0057 0.0446 0.0947
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0173 0.0455
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0138 0.1321 0.3212
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0178 0.1754 0.2197
Brugia malayi cathepsin L-like precursor 0.0174 0.1703 0.3638
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Schistosoma mansoni polycystin 1-related 0.0023 0.0084 0.0101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0366 0.0784
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.1303 0.2782
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0075 0.021
Echinococcus multilocularis cathepsin L cysteine protease 0.0253 0.256 0.256
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0075 0.0075
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0057 0.0446 0.1494
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Schistosoma mansoni cathepsin F (C01 family) 0.0253 0.256 0.3209
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0134 0.0318
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0134 0.0279
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Giardia lamblia Hypothetical protein 0.0057 0.0446 0.2211
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0366 0.1173
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0232 0.0489
Loa Loa (eye worm) cytochrome P450 0.0016 0.0004 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0174 0.1703 0.6552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0136 0.1303 0.383
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1202 0.2571
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0561 0.1193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Echinococcus granulosus cathepsin L 0.0136 0.1303 0.1635
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Trypanosoma cruzi cysteine peptidase, putative 0.0253 0.256 0.5472
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0134 0.1211
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0059 0.0135
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0134 0.0384
Echinococcus multilocularis expressed conserved protein 0.0108 0.0996 0.0996
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0232 0.0291
Trypanosoma cruzi cysteine protease, putative 0.0136 0.1303 0.2782
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0253 0.256 0.5476
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0337 0.0714
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0057 0.0446 0.1494
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.018
Onchocerca volvulus 0.0244 0.2466 0.9621
Plasmodium falciparum serine repeat antigen 5 0.0057 0.0446 0.1548
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.108 0.4043
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Schistosoma mansoni cathepsin B (C01 family) 0.0057 0.0446 0.0555
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0116 0.1086 0.2324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0116 0.1086 0.2318
Plasmodium vivax vivapain-2 0.0253 0.256 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0232 0.0497
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0173 0.0393
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0084 0.0105
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.1303 0.2782
Onchocerca volvulus 0.0031 0.0175 0.0367
Mycobacterium ulcerans hypothetical protein 0.0028 0.0134 0.0318
Loa Loa (eye worm) hypothetical protein 0.006 0.0486 0.1039
Echinococcus granulosus cathepsin L cysteine protease 0.0136 0.1303 0.1635
Trypanosoma cruzi major cysteine proteinase, putative 0.0057 0.0446 0.0947
Loa Loa (eye worm) fibroinase 0.0253 0.256 0.5476
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0253 0.256 1
Schistosoma mansoni hypothetical protein 0.0037 0.0232 0.0287
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0075 0.016
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.0374
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0057 0.0446 0.1548
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.0446 0.0954
Brugia malayi Cathepsin L-like cysteine proteinase 0.0174 0.1703 0.3638
Onchocerca volvulus 0.0253 0.256 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0134 0.0279
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.045 0.4675 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0173 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0134 0.0238
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0057 0.0446 0.0555
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.1071 0.2284
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Echinococcus multilocularis 0.0016 0.0004 0.0004
Echinococcus granulosus expressed conserved protein 0.0108 0.0996 0.125
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0173 0.0455
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0331 0.3397 0.7262
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.108 0.2309
Onchocerca volvulus 0.0031 0.0175 0.0367
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0047 0.0105
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0134 0.0384
Entamoeba histolytica cysteine proteinase, putative 0.0253 0.256 1
Entamoeba histolytica cysteine proteinase, putative 0.0174 0.1703 0.6552
Echinococcus granulosus RUN 0.0023 0.0084 0.0105
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0084 0.0084
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.108 0.4043
Plasmodium falciparum cysteine proteinase falcipain 3 0.0253 0.256 1
Giardia lamblia Cathepsin B precursor 0.0057 0.0446 0.2211
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0232 0.0489
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.03 0.0905
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0057 0.0446 0.0954
Schistosoma mansoni hypothetical protein 0.0023 0.0084 0.0101
Schistosoma mansoni cathepsin F (C01 family) 0.0253 0.256 0.3209
Loa Loa (eye worm) hypothetical protein 0.045 0.4675 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0136 0.1303 0.4942
Brugia malayi 6-phosphofructokinase 0.0116 0.108 0.2303
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0337 0.0714
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0174 0.1703 0.6552
Onchocerca volvulus Cathepsin L homolog 0.0057 0.0446 0.1462
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0137 0.1315 0.165
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0134 0.0318
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0084 0.01
Entamoeba histolytica cysteine protease, putative 0.0253 0.256 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0253 0.256 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0446 0.1494
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.108 0.2303
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.108 0.108
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0288 0.0288
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Echinococcus granulosus cathepsin l1 0.0174 0.1703 0.2137
Schistosoma mansoni intermediate filament proteins 0.0031 0.0175 0.0215
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0156 0.0196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.108 0.1355
Onchocerca volvulus 0.0253 0.256 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.045 0.4675 0.5864
Echinococcus multilocularis cysteine protease 0.0253 0.256 0.256
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0873
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.045 0.4675 0.5864
Echinococcus multilocularis lamin dm0 0.0031 0.0175 0.0175
Brugia malayi Cytochrome P450 family protein 0.0057 0.0454 0.0963
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0057 0.0446 0.1494
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.1303 0.1631
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0173 0.0661
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0253 0.256 0.256
Echinococcus multilocularis cysteine protease 0.0253 0.256 0.256
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0136 0.1303 0.1631
Onchocerca volvulus Cathepsin L homolog 0.0253 0.256 1
Brugia malayi Cathepsin L-like precursor 0.008 0.0694 0.1477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0873
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0168 0.0168
Schistosoma mansoni aldehyde dehydrogenase 0.0138 0.1321 0.1653
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1202 0.2571
Brugia malayi cathepsin B-like cysteine proteinase 0.045 0.4675 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0173 0.0455
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0057 0.0446 0.1548
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0178 0.1754 0.6757
Echinococcus granulosus cathepsin L cysteine proteinase 0.0253 0.256 0.3212
Giardia lamblia Cysteine protease 0.0057 0.0446 0.2211
Brugia malayi hypothetical protein 0.0023 0.0084 0.0172
Loa Loa (eye worm) hypothetical protein 0.0028 0.0134 0.0287
Echinococcus granulosus neuropeptide s receptor 0.0541 0.5653 0.7092
Echinococcus multilocularis protein patched 0.0049 0.0366 0.0366
Brugia malayi Cathepsin L-like precursor 0.0174 0.1703 0.3638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0884 0.1109
Mycobacterium ulcerans epoxide hydrolase EphA 0.0397 0.4105 1
Entamoeba histolytica hypothetical protein 0.0042 0.0288 0.0857
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0454 0.097
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0561 0.12
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0136 0.1303 0.2782
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2147 0.4593
Loa Loa (eye worm) hypothetical protein 0.0116 0.1086 0.2324
Echinococcus multilocularis cathepsin b 0.045 0.4675 0.4675
Leishmania major mitochondrial DNA polymerase beta 0.0331 0.3397 1
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Schistosoma mansoni inositol monophosphatase 0.0043 0.03 0.0372
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.03 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0884 0.1109
Schistosoma mansoni cathepsin s 0.008 0.0694 0.0866
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Echinococcus multilocularis RUN 0.0023 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0446 0.1494
Echinococcus multilocularis GPCR, family 2 0.0037 0.0232 0.0232
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.03 0.03
Toxoplasma gondii aldehyde dehydrogenase 0.0138 0.1321 0.5152
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0134 0.0318
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0137 0.1315 0.1315
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Echinococcus granulosus cathepsin l1 0.0253 0.256 0.3212
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0251 0.2301
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0057 0.0446 0.2211
Schistosoma mansoni lamin 0.0031 0.0175 0.0215
Onchocerca volvulus 0.0057 0.0446 0.1462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0138 0.1321 0.1321
Entamoeba histolytica cysteine proteinase, putative 0.0136 0.1303 0.4942
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0178 0.1754 0.5159
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Echinococcus granulosus cathepsin l cysteine peptidase 0.0253 0.256 0.3212
Giardia lamblia Cathepsin B precursor 0.0178 0.1754 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0232 0.0291
Plasmodium falciparum cysteine proteinase falcipain 1 0.0136 0.1303 0.4974
Plasmodium falciparum serine repeat antigen 7 0.0057 0.0446 0.1548
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.108 0.2623
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0253 0.256 0.5476
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0057 0.0446 0.1548
Loa Loa (eye worm) cysteine protease 0.0253 0.256 0.5476
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Onchocerca volvulus Cathepsin F homolog 0.0253 0.256 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0634
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0288 0.0357
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.108 0.4043
Entamoeba histolytica cysteine proteinase 2 0.0136 0.1303 0.4942
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0253 0.256 1
Plasmodium falciparum serine repeat antigen 9 0.0057 0.0446 0.1548
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0175 0.0374
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0232 0.0232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0884 0.189
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0446 0.1548
Plasmodium vivax serine-repeat antigen (SERA) 0.0057 0.0446 0.1548
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0168 0.0207
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0173 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0057 0.0446 0.1494
Echinococcus multilocularis neuropeptide receptor A26 0.0541 0.5653 0.5653
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0057 0.0446 0.0947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0884 0.0884
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0134 0.0318
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0134 0.0238
Giardia lamblia Cathepsin L precursor 0.0057 0.0446 0.2211
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0057 0.0446 0.1548
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0134 0.0238
Plasmodium vivax unspecified product 0.0136 0.1303 0.4974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0168 0.0207
Loa Loa (eye worm) hypothetical protein 0.0057 0.0446 0.0954
Onchocerca volvulus 0.0174 0.1703 0.6539
Brugia malayi Cathepsin L-like precursor 0.0253 0.256 0.5472
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0366 0.0366
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0253 0.256 1
Brugia malayi CHE-14 protein 0.0049 0.0366 0.0776
Echinococcus granulosus cysteine protease 0.0136 0.1303 0.1635
Schistosoma mansoni cathepsin C 0.0057 0.0446 0.0555
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0253 0.256 0.7535
Brugia malayi TAR-binding protein 0.0067 0.0561 0.1193
Echinococcus granulosus GPCR family 2 0.0037 0.0232 0.0291
Entamoeba histolytica cysteine protease, putative 0.0136 0.1303 0.4942
Echinococcus multilocularis cathepsin L 0.0057 0.0446 0.0446
Brugia malayi Cytochrome P450 family protein 0.0025 0.0107 0.0221
Brugia malayi Papain family cysteine protease containing protein 0.0136 0.1303 0.2782
Schistosoma mansoni hypothetical protein 0.0047 0.0347 0.0431
Loa Loa (eye worm) inositol-1 0.0043 0.03 0.0641
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0168 0.0168
Entamoeba histolytica cysteine protease, putative 0.0057 0.0446 0.1494
Leishmania major cytochrome p450-like protein 0.0025 0.0107 0.0304
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0253 0.256 0.256
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0057 0.0446 0.0555
Echinococcus granulosus cathepsin b 0.045 0.4675 0.5866
Leishmania major cathepsin L-like protease 0.0253 0.256 0.7535
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0561 0.07
Echinococcus granulosus lamin 0.0031 0.0175 0.0219
Trypanosoma cruzi cysteine proteinase, putative 0.0136 0.1303 0.2782
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0075 0.0152
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0057 0.0446 0.1548
Echinococcus multilocularis Niemann Pick C1 protein 0.0164 0.16 0.16
Brugia malayi Cytochrome P450 family protein 0.0025 0.0107 0.0221
Echinococcus multilocularis protein dispatched 1 0.0056 0.0441 0.0441
Plasmodium vivax vivapain-1 0.0136 0.1303 0.4974
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0253 0.256 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0075 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0253 0.256 1
Plasmodium falciparum serine repeat antigen 6 0.0057 0.0446 0.1548
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0057 0.0446 0.1548
Brugia malayi follicle stimulating hormone receptor 0.0275 0.2797 0.598
Echinococcus granulosus Niemann Pick C1 protein 0.0164 0.16 0.2008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.008 0.0694 0.1484
Schistosoma mansoni cathepsin S (C01 family) 0.0057 0.0446 0.0555
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0634
Toxoplasma gondii preprocathepsin c precursor, putative 0.0057 0.0446 0.173
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.0446 0.0947
Entamoeba histolytica hypothetical protein 0.0057 0.0446 0.1494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.0446 0.1494

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 300 uM Cytotoxicity concentration to inhibit hepatitis C virus RNA replication in a subgenomic replicon cell line ChEMBL. 15664842
EC50 (functional) = 3.3 uM Inhibition of hepatitis C virus RNA replication in a subgenomic replicon cell line ChEMBL. 15664842

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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