TDR Targets

Basic information

Technical information

TDR Targets ID: 326574
Name: 4-[2-(4-fluorophenyl)pyrazolo[5,1-f]pyridazin -3-yl]-N-phenylpyrimidin-2-amine
MW: 382.393 | Formula: C22H15FN6
H donors: 1 H acceptors: 4 LogP: 4.21 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)c1nn2c(c1c1ccnc(n1)Nc1ccccc1)cccn2
InChi: 1S/C22H15FN6/c23-16-10-8-15(9-11-16)21-20(19-7-4-13-25-29(19)28-21)18-12-14-24-22(27-18)26-17-5-2-1-3-6-17/h1-14H,(H,24,26,27)
InChiKey: WBNBKUXDNWEDOY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[2-(4-fluorophenyl)pyrazolo[5,1-f]pyridazin-3-yl]-N-phenyl-pyrimidin-2-amine
4-[2-(4-fluorophenyl)-3-pyrazolo[5,1-f]pyridazinyl]-N-phenyl-2-pyrimidinamine
[4-[2-(4-fluorophenyl)pyrazolo[5,1-f]pyridazin-3-yl]pyrimidin-2-yl]-phenyl-amine
pyrazolo[1,5-b]pyridazine deriv. 63

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References
Homo sapiens	cyclin-dependent kinase 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126712	All targets in OG5_126712
Neospora caninum	CMGC kinase, CDK family TgPK2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	cell division control protein 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei	cdc2-related kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	Cell division control protein 2 homolog	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02087 cyclin-dependent kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium falciparum	protein kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma cruzi	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Schistosoma japonicum	ko:K02090 cyclin-dependent kinase 5, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	cell division related protein kinase 2, putative,CDC2-related protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania mexicana	cell division related protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	cyclin dependent kinase 1	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	cdc2-like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Theileria parva	cell division control protein 2 related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Cryptosporidium parvum	Cdc2-like CDK2/CDC28 like protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma brucei gambiense	cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC CDK	Get druggable targets OG5_126712	All targets in OG5_126712
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	protein kinase Crk2	Get druggable targets OG5_126712	All targets in OG5_126712
Entamoeba histolytica	cell division protein kinase 2, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	cdc2-related kinase 1, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cdc2-related kinase 3, putative	Get druggable targets OG5_126712	All targets in OG5_126712
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	cyclin dependent kinase 5	Get druggable targets OG5_126712	All targets in OG5_126712
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	cdc2-related kinase 3	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	cell division protein kinase 2,cdc2-related kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126712	All targets in OG5_126712
Leishmania donovani	cell division protein kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Plasmodium berghei	cdc2-related kinase 2	Get druggable targets OG5_126712	All targets in OG5_126712
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	cyclin dependent kinase	Get druggable targets OG5_126712	All targets in OG5_126712
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	cyclin-dependent kinase 3	305 aa	303 aa	32.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	aldehyde dehydrogenase	0.0055	0.0203	0.0457
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0104	0.0496	0.0973
Echinococcus multilocularis	dna polymerase eta	0.0123	0.0614	0.0612
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0031	0.0178
Schistosoma mansoni	glutamate receptor kainate	0.0202	0.1091	0.2486
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.0186	0.5929
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0186	0.2974
Echinococcus multilocularis	expressed conserved protein	0.0106	0.0506	0.0504
Onchocerca volvulus		0.0033	0.0068	0.1013
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0168	0.0885	0.5918
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0222	0.0577
Echinococcus multilocularis	glutamate receptor NMDA	0.049	0.2837	0.2835
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0031	0.0081
Echinococcus multilocularis	cyclin dependent kinase	0.0053	0.0186	0.0184
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0041	0.1175
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0212	0.1152	0.7748
Schistosoma mansoni	glutamate receptor AMPA	0.0202	0.1091	0.2486
Schistosoma mansoni	tyrosine kinase	0.0053	0.019	0.0428
Toxoplasma gondii	aldehyde dehydrogenase	0.0055	0.0203	0.6412
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Echinococcus granulosus	snurportin 1	0.0306	0.1723	0.339
Mycobacterium tuberculosis	Probable dehydrogenase	0.0168	0.0885	0.5918
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0068	0.015
Schistosoma mansoni	metabotropic glutamate receptor	0.0053	0.019	0.0428
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0053	0.019	0.0187
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0008	0.0055
Plasmodium falciparum	thioredoxin reductase	0.0074	0.0313	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0178
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0053	0.0186	0.0362
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0055	0.0203	0.3245
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0031	0.0178
Loa Loa (eye worm)	hypothetical protein	0.013	0.0652	0.1696
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0031	0.0053	0.0115
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Plasmodium vivax	thioredoxin reductase, putative	0.0074	0.0313	1
Echinococcus multilocularis	dna polymerase kappa	0.0073	0.0311	0.0308
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0053	0.0186	0.5876
Trypanosoma brucei	unspecified product	0.005	0.0173	0.2758
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0053	0.019	0.0494
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0.019	0.0494
Brugia malayi	cell division control protein 2 homolog	0.0053	0.0186	0.0478
Schistosoma mansoni	hypothetical protein	0.014	0.0717	0.1631
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0097	0.0215
Plasmodium vivax	glutathione reductase, putative	0.0074	0.0313	1
Brugia malayi	beta-lactamase family protein	0.0033	0.0068	0.0171
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0059	0.0222	0.3562
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0614	0.1598
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0203	0.1341
Chlamydia trachomatis	glutamine binding protein	0.0266	0.148	1
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0186	0.0419
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0026	0.0022	0.0279
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0067	0.0275	0.0622
Echinococcus multilocularis	neuropeptide receptor A26	0.0392	0.224	0.2238
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0548	0.1425
Onchocerca volvulus		0.0059	0.0222	0.338
Onchocerca volvulus		0.0053	0.019	0.2884
Schistosoma mansoni	ATP-binding cassette transporter	0.0202	0.1091	0.2486
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0026	0.0022	0.0551
Echinococcus granulosus	nmda type glutamate receptor	0.0544	0.3159	0.6219
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0053	0.019	0.0369
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0033	0.0068	0.043
Plasmodium falciparum	glutathione reductase	0.0026	0.0022	0.0551
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.0097	0.0185
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0026	0.0022	0.0038
Loa Loa (eye worm)	hypothetical protein	0.013	0.0652	0.1696
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0053	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0445	0.1157
Brugia malayi	jmjC domain containing protein	0.0182	0.097	0.252
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0097	0.0215
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0203	0.1341
Onchocerca volvulus		0.0033	0.0068	0.1013
Brugia malayi	hypothetical protein	0.0027	0.0029	0.0068
Schistosoma mansoni	hypothetical protein	0.0104	0.0496	0.1127
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.0097	0.0094
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0255	0.1414	0.1412
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.0311	0.5016
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0031	0.0064
Mycobacterium tuberculosis	Probable oxidoreductase	0.0187	0.0998	0.6697
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0026	0.0022	0.0556
Loa Loa (eye worm)	jmjC domain-containing protein	0.0067	0.0275	0.0715
Toxoplasma gondii	ABC1 family protein	0.0033	0.0068	0.2056
Brugia malayi	ImpB/MucB/SamB family protein	0.0123	0.0614	0.1593
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0031	0.0053	0.0785
Onchocerca volvulus	Huntingtin homolog	0.013	0.0652	1
Loa Loa (eye worm)	glutamate receptor	0.0053	0.019	0.0494
Schistosoma mansoni	aldehyde dehydrogenase	0.0055	0.0203	0.0457
Echinococcus multilocularis	snurportin 1	0.0306	0.1723	0.1721
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0031	0.0074
Brugia malayi	intracellular kinase	0.0059	0.0222	0.0571
Giardia lamblia	Kinase, CMGC CDK	0.0053	0.0186	0.5929
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0186	0.5884
Mycobacterium leprae	Probable lipase LipE	0.0033	0.0068	0.0384
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0053	0.019	0.2884
Echinococcus multilocularis	Niemann Pick C1 protein	0.0161	0.084	0.0837
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0168	0.0437
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0186	0.3298
Echinococcus multilocularis	neuropeptide s receptor	0.0392	0.224	0.2238
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0222	0.707
Echinococcus multilocularis	protein kinase shaggy	0.0059	0.0222	0.022
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0073	0.0189
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.0222	0.7103
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Loa Loa (eye worm)	beta-lactamase	0.0033	0.0068	0.0178
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0068	0.1041
Brugia malayi	metabotropic glutamate receptor type 2	0.0053	0.019	0.0488
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0168	0.0885	0.8826
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0073	0.0311	0.0808
Schistosoma mansoni	metabotropic glutamate receptor	0.0053	0.019	0.0428
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0168	0.043
Schistosoma mansoni	hypothetical protein	0.0034	0.0073	0.016
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0159	0.0414
Schistosoma mansoni	importin beta-1	0.0029	0.0041	0.0088
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0104	0.0496	0.0494
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Echinococcus granulosus	glutamate receptor NMDA	0.049	0.2837	0.5583
Echinococcus multilocularis	nmda type glutamate receptor	0.0544	0.3159	0.3158
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0186	0.0478
Trypanosoma brucei	protein kinase, putative	0.0059	0.0222	0.3562
Leishmania major	DNA polymerase eta, putative	0.0073	0.0309	0.4984
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0168	0.0885	0.5918
Trichomonas vaginalis	DNA polymerase eta, putative	0.0073	0.0311	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0168	0.0885	0.5918
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0033	0.0068	0.0171
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Echinococcus multilocularis	cyclin dependent kinase 5	0.0053	0.0186	0.0184
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0266	0.148	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Plasmodium vivax	hypothetical protein, conserved	0.0033	0.0068	0.2056
Loa Loa (eye worm)	thioredoxin reductase	0.0074	0.0313	0.0815
Brugia malayi	hypothetical protein	0.0053	0.019	0.0488
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0059	0.0222	0.7039
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0055	0.0203	0.0394
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0029	0.0772
Schistosoma mansoni	protein kinase	0.0053	0.019	0.0428
Mycobacterium ulcerans	DNA polymerase IV	0.0073	0.0311	0.2073
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0073	0.0311	0.5016
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0031	0.0053	0.005
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Brugia malayi	PHD-finger family protein	0.0056	0.0204	0.0525
Mycobacterium leprae	conserved hypothetical protein	0.0033	0.0068	0.0384
Brugia malayi	glutathione reductase	0.0074	0.0313	0.0809
Brugia malayi	Glutamate receptor 2 precursor	0.0202	0.1091	0.2835
Echinococcus granulosus	glutamate receptor 2	0.0152	0.0785	0.1541
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0026	0.0022	0.0279
Echinococcus granulosus	jumonji domain containing protein	0.0077	0.0336	0.0657
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0029	0.0772
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0026	0.0022	0.0279
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0182	0.097	0.0968
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0255	0.1414	0.2781
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.037	0.2109	0.2107
Echinococcus granulosus	expressed conserved protein	0.0106	0.0506	0.0993
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0022	0.0002	0.0006
Mycobacterium tuberculosis	Probable esterase LipL	0.0033	0.0068	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0225	0.0585
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Mycobacterium ulcerans	lipase LipD	0.0033	0.0068	0.043
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0026	0.0022	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Brugia malayi	Receptor family ligand binding region containing protein	0.0053	0.019	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Echinococcus multilocularis	Niemann Pick C1 protein	0.0112	0.0548	0.0545
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0056	0.0204	0.046
Brugia malayi	Glutamate receptor 1 precursor	0.0202	0.1091	0.2835
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0187	0.0998	1
Giardia lamblia	Kinase, CMGC GSK	0.0059	0.0222	0.7103
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0053	0.019	0.0494
Schistosoma mansoni	glutamate receptor kainate	0.0202	0.1091	0.2486
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0202	0.1091	0.1089
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0104	0.0496	0.0494
Echinococcus multilocularis	geminin	0.014	0.0717	0.0715
Echinococcus granulosus	Niemann Pick C1 protein	0.0161	0.084	0.1649
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0053	0.019	0.0488
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0055	0.0203	0.1341
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0104	0.0496	0.0973
Onchocerca volvulus	Huntingtin homolog	0.013	0.0652	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0074	0.0316	0.0314
Mycobacterium ulcerans	DNA polymerase IV	0.0073	0.0311	0.2073
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0031	0.0053	0.0099
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0053	0.019	0.0369
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0031	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0104	0.0496	0.0494
Mycobacterium tuberculosis	Probable lipase LipD	0.0033	0.0068	0.0319
Brugia malayi	Receptor family ligand binding region containing protein	0.0053	0.019	0.0488
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0186	0.5884
Trypanosoma cruzi	DNA polymerase eta, putative	0.0123	0.0614	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0026	0.0022	0.0279
Echinococcus granulosus	beta LACTamase domain containing family member	0.0033	0.0068	0.013
Schistosoma mansoni	jumonji domain containing protein	0.0145	0.0744	0.1692
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0186	0.0184
Trypanosoma brucei	DNA polymerase kappa, putative	0.005	0.0173	0.2758
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0186	0.0484
Mycobacterium tuberculosis	Probable lipase LipE	0.0033	0.0068	0.0319
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0055	0.0203	0.02
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0026	0.0022	0.0115
Trypanosoma brucei	unspecified product	0.005	0.0173	0.2758
Onchocerca volvulus		0.0053	0.019	0.2884
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0059	0.0222	0.0432
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0255	0.1414	0.1412
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0008	0.0055
Brugia malayi	Bromodomain containing protein	0.0056	0.0204	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0178
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.0159	0.0157
Echinococcus granulosus	glutamate receptor 2	0.0255	0.1414	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0053	0.0137
Brugia malayi	Guanylyl cyclase protein 23	0.0053	0.019	0.0488
Leishmania major	DNA polymerase eta, putative	0.0123	0.0614	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0029	0.0772
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0182	0.097	0.1907
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0266	0.148	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.0311	0.5016
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0073	0.0311	0.0703
Echinococcus multilocularis	peregrin	0.0056	0.0204	0.0202
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0026	0.0022	0.0279
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0031	0.0424
Trypanosoma cruzi	DNA polymerase eta, putative	0.0073	0.0309	0.4984
Schistosoma mansoni	tyrosine kinase	0.0053	0.019	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Trypanosoma brucei	unspecified product	0.0073	0.0311	0.5016
Echinococcus granulosus	lysine specific demethylase 5A	0.0067	0.0275	0.0537
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0031	0.0053	0.0099
Brugia malayi	polk-prov protein	0.0023	0.0005	0.0006
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0031	0.0064
Echinococcus granulosus	cyclin dependent kinase	0.0053	0.0186	0.0362
Echinococcus granulosus	ubiquitin specific protease 41	0.0031	0.0053	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0005	0.0013
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0026	0.0022	0.0551
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0073	0.0311	0.0308
Plasmodium falciparum	protein kinase 5	0.0053	0.0186	0.5876
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.0068	0.0178
Plasmodium vivax	protein kinase Crk2	0.0053	0.0186	0.5876
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0068	0.0319
Echinococcus multilocularis	nmda type glutamate receptor	0.0861	0.5079	0.5078
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0031	0.0053	0.0825
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0053	0.0186	0.0484
Brugia malayi	hypothetical protein	0.013	0.0652	0.169
Schistosoma mansoni	DNA polymerase eta	0.0123	0.0614	0.1397
Echinococcus granulosus	nmda type glutamate receptor	0.0861	0.5079	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0031	0.0431
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0059	0.0222	0.0501
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0026	0.0022	0.0279
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0059	0.0222	0.022
Entamoeba histolytica	hypothetical protein	0.0053	0.019	0.3366
Plasmodium vivax	hypothetical protein, conserved	0.0056	0.0204	0.6458
Echinococcus multilocularis	glutamate receptor 2	0.0152	0.0785	0.0783
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0041	0.0595
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0033	0.0068	0.015
Trypanosoma brucei	DNA polymerase eta, putative	0.0123	0.0614	1
Onchocerca volvulus		0.0027	0.0031	0.0441
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0068	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0178
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0073	0.0311	0.198
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0031	0.0053	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0178
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0073	0.0311	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0031	0.0053	0.005
Mycobacterium ulcerans	beta-lactamase	0.0033	0.0068	0.043
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0053	0.019	0.0187
Brugia malayi	ImpB/MucB/SamB family protein	0.0073	0.0311	0.0802
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0031	0.0178
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0055	0.0203	0.124
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0038	0.0097	0.0094
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0266	0.148	1
Leishmania major	hypothetical protein, conserved	0.0033	0.0068	0.1041
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0068	0.1987
Trypanosoma brucei	DNA polymerase kappa, putative	0.005	0.0173	0.2758
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0031	0.0053	0.0131
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0041	0.1175
Schistosoma mansoni	glutamate receptor kainate	0.0202	0.1091	0.2486
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0074	0.0313	0.1999
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0187	0.0998	0.6697
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0068	0.1987
Echinococcus granulosus	neuropeptide s receptor	0.0392	0.224	0.4407
Brugia malayi	Niemann-Pick C1 protein precursor	0.0112	0.0548	0.1419
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0041	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0029	0.0075
Trypanosoma cruzi	cdc2-related kinase 3	0.0053	0.0186	0.2974
Giardia lamblia	DINP protein human, muc B family	0.0073	0.0311	1
Leishmania major	extracellular receptor, putative	0.0053	0.019	0.3034
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0255	0.1414	0.1412
Echinococcus granulosus	dna polymerase eta	0.0123	0.0614	0.1206
Echinococcus granulosus	thioredoxin glutathione reductase	0.0074	0.0316	0.0618
Trichomonas vaginalis	glutathione reductase, putative	0.0026	0.0022	0.045
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0.019	0.0494
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0073	0.0309	0.9849
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0033	0.0068	0.0319
Echinococcus granulosus	neuropeptide receptor A26	0.0392	0.224	0.4407
Trichomonas vaginalis	CMGC family protein kinase	0.0059	0.0222	0.707
Brugia malayi	CHE-14 protein	0.0048	0.0159	0.0408
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0029	0.0391
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0002	0.0006
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0029	0.0391
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0031	0.0053	0.1566
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0026	0.0022	0.005
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0031	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Entamoeba histolytica	protein kinase, putative	0.0059	0.0222	0.3963
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0204	0.0531
Trichomonas vaginalis	esterase, putative	0.0033	0.0068	0.1987
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0041	0.0107
Loa Loa (eye worm)	intermediate filament protein	0.0022	0.0002	0.0006
Echinococcus granulosus	protein kinase shaggy	0.0059	0.0222	0.0432
Leishmania major	trypanothione reductase	0.0074	0.0313	0.5061
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0067	0.0275	0.0622
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0059	0.0222	0.0577
Trypanosoma brucei	DNA polymerase IV, putative	0.0073	0.0311	0.5016
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0053	0.019	0.0488
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0038	0.0097	0.0251
Trichomonas vaginalis	penicillin-binding protein, putative	0.0033	0.0068	0.1987
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0053	0.019	0.0187
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0031	0.0074
Plasmodium falciparum	phd finger protein, putative	0.0056	0.0204	0.6458
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0053	0.0186	0.0484
Schistosoma mansoni	patched 1	0.0048	0.0159	0.0358
Giardia lamblia	PHD finger protein 15	0.0056	0.0204	0.6516
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0053	0.0186	0.2974
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Echinococcus granulosus	receptor type guanylyl cyclase	0.0053	0.019	0.0369
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0026	0.0022	0.0279
Echinococcus granulosus	PHD finger protein rhinoceros	0.0056	0.0204	0.0397
Trypanosoma brucei	cdc2-related kinase 3	0.0053	0.0186	0.2974
Brugia malayi	Importin beta-1 subunit	0.0029	0.0041	0.01
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0186	0.0419
Schistosoma mansoni	glutamate receptor NMDA	0.0202	0.1091	0.2486
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0053	0.019	0.0369
Trypanosoma brucei	DNA polymerase kappa, putative	0.005	0.0173	0.2758
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0038	0.0097	0.0185
Leishmania major	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Loa Loa (eye worm)	glutamate receptor 2	0.0202	0.1091	0.284
Echinococcus granulosus	peregrin	0.0056	0.0204	0.0397
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0031	0.0431
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0031	0.0074
Schistosoma mansoni	hypothetical protein	0.014	0.0717	0.1631
Trypanosoma brucei	trypanothione reductase	0.0074	0.0313	0.5061
Echinococcus multilocularis	jumonji domain containing protein	0.0077	0.0336	0.0334
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0031	0.0053	0.1472
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0168	0.043
Onchocerca volvulus		0.0033	0.0068	0.1013
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0104	0.0496	0.0973
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0041	0.0595
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0029	0.0391
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0073	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0031	0.0081
Mycobacterium tuberculosis	Conserved protein	0.0033	0.0068	0.0319
Trypanosoma cruzi	hypothetical protein, conserved	0.0033	0.0068	0.1041
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0657	0.3844	1
Brugia malayi	beta-lactamase	0.0033	0.0068	0.0171
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0031	0.0053	0.0785
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0053	0.019	0.0187
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0255	0.1414	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0031	0.0081
Schistosoma mansoni	hypothetical protein	0.0046	0.0149	0.0334
Plasmodium falciparum	importin beta, putative	0.0029	0.0041	0.1175
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0033	0.0068	0.0066
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0186	0.5884
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0059	0.0222	0.3562
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0179	0.0467
Mycobacterium tuberculosis	Probable reductase	0.0168	0.0885	0.5918
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0026	0.0022	0.0115
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0255	0.1414	0.2781
Echinococcus granulosus	geminin	0.014	0.0717	0.1408
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0038	0.0097	0.0215
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0112	0.0548	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0031	0.0178
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0186	0.2974
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0068	0.1987
Loa Loa (eye worm)	PHD-finger family protein	0.0056	0.0204	0.0531
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0026	0.0022	0.5
Plasmodium falciparum	glycogen synthase kinase 3	0.0059	0.0222	0.7039
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0026	0.0022	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0178
Trypanosoma brucei	hypothetical protein, conserved	0.0033	0.0068	0.1041
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0053	0.0186	0.2974
Echinococcus granulosus	dna polymerase kappa	0.0073	0.0311	0.0607
Toxoplasma gondii	thioredoxin reductase	0.0074	0.0313	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.0053	0.0186	0.3298
Echinococcus multilocularis	protein patched	0.0048	0.0159	0.0157
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0187	0.0998	0.6697
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0056	0.0204	0.0202
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	0.1723	0.4483
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0031	0.0053	0.0785
Mycobacterium ulcerans	esterase/lipase LipP	0.0033	0.0068	0.043
Toxoplasma gondii	NADPH-glutathione reductase	0.0026	0.0022	0.0551
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0031	0.0424
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.0159	0.0309
Leishmania major	hypothetical protein, conserved	0.0027	0.0029	0.0391
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0073	0.0311	0.5604
Trichomonas vaginalis	D-aminoacylase, putative	0.0033	0.0068	0.1987
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0104	0.0496	0.0973
Toxoplasma gondii	PHD-finger domain-containing protein	0.0056	0.0204	0.6458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0026	0.0022	0.0551
Echinococcus granulosus	cyclin dependent kinase 1	0.0053	0.0186	0.0362
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0041	0.0076
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0033	0.0068	0.0319
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0031	0.0053	0.1472
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0053	0.019	0.0494
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0255	0.1414	0.2781
Mycobacterium tuberculosis	Probable hydrolase	0.0033	0.0068	0.0319
Echinococcus multilocularis	ubiquitin specific protease 41	0.0031	0.0053	0.005
Loa Loa (eye worm)	hypothetical protein	0.0053	0.019	0.0494
Trichomonas vaginalis	mercuric reductase, putative	0.0026	0.0022	0.045
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0073	0.0311	0.198
Echinococcus multilocularis	glutamate receptor 2	0.0255	0.1414	0.1412
Schistosoma mansoni	hypothetical protein	0.0056	0.0204	0.046
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.0159	0.0414
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0026	0.0022	0.0115
Brugia malayi	beta-lactamase family protein	0.0033	0.0068	0.0171
Echinococcus multilocularis	glutamate receptor 2	0.0202	0.1091	0.1089
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0033	0.0068	0.0319
Trypanosoma cruzi	extracellular receptor, putative	0.0053	0.019	0.3034
Echinococcus multilocularis	lysine specific demethylase 5A	0.0067	0.0275	0.0273
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0026	0.0022	0.0279
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.0159	0.0309
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0031	0.0178
Trypanosoma brucei	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Brugia malayi	jmjC domain containing protein	0.0067	0.0275	0.0709
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0031	0.0178
Echinococcus granulosus	tyrosine kinase	0.0053	0.019	0.0369
Echinococcus multilocularis	cyclin dependent kinase 1	0.0053	0.0186	0.0184
Loa Loa (eye worm)	jmjC domain-containing protein	0.0115	0.0563	0.1464
Plasmodium falciparum	thioredoxin reductase	0.0026	0.0022	0.0551
Schistosoma mansoni	DNA polymerase IV / kappa	0.0023	0.0005	0.0005
Plasmodium falciparum	glutathione reductase	0.0074	0.0313	1
Loa Loa (eye worm)	glutathione reductase	0.0074	0.0313	0.0815
Schistosoma mansoni	hypothetical protein	0.0046	0.0149	0.0334
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0159	0.4996
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0114	0.0558	0.1269
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0073	0.0311	0.5016
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0026	0.0022	0.0551
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0222	0.3963
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0168	0.0885	0.5918
Entamoeba histolytica	protein kinase domain containing protein	0.0059	0.0222	0.3963
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0026	0.0022	0.0044
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0038	0.0097	0.0245
Echinococcus granulosus	Niemann Pick C1 protein	0.0112	0.0548	0.1074
Trypanosoma cruzi	cdc2-related kinase 1	0.0053	0.0186	0.2974
Loa Loa (eye worm)	glutamate receptor 1	0.0202	0.1091	0.284
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0266	0.148	1
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0031	0.0053	0.0785
Brugia malayi	RNA, U transporter 1	0.0082	0.0362	0.0935
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0026	0.0022	0.0551
Schistosoma mansoni	hypothetical protein	0.0046	0.0149	0.0334
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0202	0.1091	0.2145
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0255	0.1414	0.1412
Echinococcus multilocularis	NMDA receptor	0.0104	0.0496	0.0494
Trypanosoma brucei	cdc2-related kinase 1	0.0053	0.0186	0.2974
Schistosoma mansoni	glutamate receptor AMPA	0.0202	0.1091	0.2486
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0059	0.0222	0.7039
Brugia malayi	Thioredoxin reductase	0.0074	0.0313	0.0809
Loa Loa (eye worm)	hypothetical protein	0.005	0.0168	0.0437
Schistosoma mansoni	hypothetical protein	0.0046	0.0149	0.0334
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0029	0.0772
Brugia malayi	follicle stimulating hormone receptor	0.0657	0.3844	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0031	0.0178
Schistosoma mansoni	glutamate receptor NMDA	0.0746	0.4384	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0073	0.0311	0.0607
Echinococcus multilocularis	tyrosine kinase	0.0053	0.019	0.0187
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0031	0.0431
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0266	0.148	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0026	0.0022	0.0279
Toxoplasma gondii	PHD-finger domain-containing protein	0.0056	0.0204	0.6458
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0053	0.019	0.0494
Echinococcus granulosus	cyclin dependent kinase 5	0.0053	0.0186	0.0362
Onchocerca volvulus	Alhambra homolog	0.0056	0.0204	0.3104
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0073	0.0311	0.0703
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0201	0.0198
Trypanosoma cruzi	trypanothione reductase, putative	0.0026	0.0022	0.0279
Mycobacterium ulcerans	hypothetical protein	0.0033	0.0068	0.043
Trypanosoma cruzi	trypanothione reductase, putative	0.0074	0.0313	0.5061
Schistosoma mansoni	hypothetical protein	0.0306	0.1723	0.3928

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.02 uM	Binding affinity for human glycogen synthase kinase 3 beta	ChEMBL.	15341487
Ki (binding)	= 0.02 uM	Binding affinity for human glycogen synthase kinase 3 beta	ChEMBL.	15341487
Ki (binding)	> 19.95 uM	Binding affinity for human cyclin-dependent kinase 2	ChEMBL.	15341487
Ki (binding)	> 19.95 uM	Binding affinity for human cyclin-dependent kinase 2	ChEMBL.	15341487

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL186425
PubChem: 6539405

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 326574