Detailed information for compound 329353

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 938.208 | Formula: C34H26Br4N4O8
  • H donors: 6 H acceptors: 6 LogP: 8.93 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 3
  • SMILES: O/N=C/1\Cc2ccc(c(c2)Br)Oc2cc(C/C(=N\O)/C(=O)N/C=C/c3ccc(Oc4cc(CCNC1=O)cc(Br)c4O)c(Br)c3)cc(c2O)Br
  • InChi: 1S/C34H26Br4N4O8/c35-21-9-17-1-3-27(21)49-29-15-19(11-23(37)31(29)43)6-8-40-33(45)25(41-47)13-18-2-4-28(22(36)10-18)50-30-16-20(12-24(38)32(30)44)14-26(42-48)34(46)39-7-5-17/h1-5,7,9-12,15-16,43-44,47-48H,6,8,13-14H2,(H,39,46)(H,40,45)/b7-5+,41-25+,42-26+
  • InChiKey: ZDBNBLMYAGHTJD-HIHPLZGUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens erb-b2 receptor tyrosine kinase 2 Starlite/ChEMBL References
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, beta polypeptide Starlite/ChEMBL References
Homo sapiens insulin-like growth factor 1 receptor Starlite/ChEMBL References
Homo sapiens NUAK family, SNF1-like kinase, 1 Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 4 Starlite/ChEMBL References
Homo sapiens aurora kinase B Starlite/ChEMBL References
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL References
Homo sapiens insulin receptor Starlite/ChEMBL References
Homo sapiens protein tyrosine kinase 2 Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens ryanodine receptor 1 (skeletal) Starlite/ChEMBL References
Homo sapiens EPH receptor B4 Starlite/ChEMBL References
Homo sapiens arachidonate 12-lipoxygenase Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 4 References
Homo sapiens mitogen-activated protein kinase kinase kinase 8 Starlite/ChEMBL References
Homo sapiens cyclin D1 Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens polo-like kinase 4 Starlite/ChEMBL References
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Serine/threonine-protein kinase PLK4, putative Get druggable targets OG5_134726 All targets in OG5_134726
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Ryanodine receptor 3, putative Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Protein tyrosine kinase 2 beta, putative Get druggable targets OG5_130513 All targets in OG5_130513
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni kinase Get druggable targets OG5_134726 All targets in OG5_134726
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K05327 ryanodine receptor, invertebrate, putative Get druggable targets OG5_129275 All targets in OG5_129275
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) TK/EPH protein kinase Get druggable targets OG5_126715 All targets in OG5_126715
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K04963 ryanodine receptor 3 (brain), putative Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/FAK protein kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus granulosus ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni ephrin receptor Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni ryanodine receptor related Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis insulin growth factor 1 receptor beta Get druggable targets OG5_129857 All targets in OG5_129857
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis ephrin type A receptor 4 A Get druggable targets OG5_126715 All targets in OG5_126715
Loa Loa (eye worm) ryanodine receptor Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus granulosus Serine:threonine protein kinase PLK4 Get druggable targets OG5_134726 All targets in OG5_134726
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) TK/INSR protein kinase Get druggable targets OG5_129857 All targets in OG5_129857
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis Serine:threonine protein kinase PLK4 Get druggable targets OG5_134726 All targets in OG5_134726
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase Get druggable targets OG5_132133 All targets in OG5_132133
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) ryanodine receptor Get druggable targets OG5_129275 All targets in OG5_129275
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Brugia malayi ephrin receptor 1 precursor Get druggable targets OG5_126715 All targets in OG5_126715
Onchocerca volvulus Get druggable targets OG5_126715 All targets in OG5_126715
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus protein tyrosine kinase Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_130513 All targets in OG5_130513
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Ryanodine Receptor TM 4-6 family protein Get druggable targets OG5_129275 All targets in OG5_129275
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR008957,Fibronectin, type III-like fold,domain-containing Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K05109 Eph receptor A8, putative Get druggable targets OG5_126715 All targets in OG5_126715
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126715 All targets in OG5_126715
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus granulosus ryanodine receptor 44f Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129275 All targets in OG5_129275
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase PLK4, putative Get druggable targets OG5_134726 All targets in OG5_134726
Schistosoma japonicum expressed protein Get druggable targets OG5_130513 All targets in OG5_130513
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis insulin receptor Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma japonicum ko:K04527 insulin receptor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_129857 All targets in OG5_129857
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Insulin-like peptide receptor precursor, putative Get druggable targets OG5_129857 All targets in OG5_129857
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 12-lipoxygenase 663 aa 662 aa 22.8 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 4 303 aa 312 aa 29.8 %
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0111 0.0537 0.0537
Schistosoma mansoni tyrosine kinase 0.0333 0.1893 0.1893
Plasmodium vivax serine-repeat antigen (SERA) 0.0111 0.0537 0.1854
Echinococcus granulosus cathepsin l1 0.0275 0.154 0.1531
Loa Loa (eye worm) hypothetical protein 0.0116 0.0573 0.0573
Echinococcus granulosus roundabout 2 0.0028 0.0034 0.0024
Echinococcus granulosus tyrosine protein kinase Src42A 0.0059 0.0225 0.0215
Echinococcus granulosus tyrosine protein kinase Blk 0.0055 0.0198 0.0188
Echinococcus granulosus cysteine protease 0.0223 0.1221 0.1212
Brugia malayi serine/threonine-protein kinase 6 0.0138 0.0707 0.0697
Loa Loa (eye worm) hypothetical protein 0.0111 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.1662 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.0537 0.0537
Loa Loa (eye worm) TK protein kinase 0.0025 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1662 1 1
Trypanosoma brucei aurora B kinase 0.0138 0.0707 0.1464
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0707 0.1464
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0111 0.0537 0.1854
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0034 0.0024
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0449 0.26 0.2593
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0034 0.0034
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.059 0.3464 1
Schistosoma mansoni tyrosine kinase 0.0319 0.1809 0.1809
Trypanosoma cruzi cysteine peptidase, putative 0.0387 0.2224 0.2038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Brugia malayi Papain family cysteine protease containing protein 0.0387 0.2224 0.2215
Trypanosoma cruzi cruzipain precursor, putative 0.0387 0.2224 0.2038
Echinococcus granulosus cathepsin L cysteine proteinase 0.0387 0.2224 0.2215
Giardia lamblia Cathepsin L precursor 0.0111 0.0537 0.094
Entamoeba histolytica cysteine proteinase 2 0.0223 0.1221 0.5116
Loa Loa (eye worm) fibroinase 0.0387 0.2224 0.2224
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0013 0.0013
Entamoeba histolytica cysteine protease, putative 0.0387 0.2224 1
Onchocerca volvulus Cathepsin L homolog 0.0111 0.0537 0.1788
Giardia lamblia Cysteine protease 0.0111 0.0537 0.094
Loa Loa (eye worm) hypothetical protein 0.0111 0.0537 0.0537
Giardia lamblia Cathepsin B precursor 0.0111 0.0537 0.094
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0707 0.1464
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0111 0.0537 0.094
Onchocerca volvulus Serine\/threonine kinase homolog 0.0061 0.0234 0.0373
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Echinococcus granulosus Immunoglobulin 0.0041 0.0114 0.0104
Echinococcus multilocularis plexin a4 0.0025 0.0014 0.0003
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.0154 0.0143
Onchocerca volvulus 0.0387 0.2224 0.9645
Schistosoma mansoni tyrosine kinase 0.0442 0.2559 0.2559
Giardia lamblia Cathepsin B precursor 0.059 0.3464 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0114 0.0114
Echinococcus multilocularis epidermal growth factor receptor 0.0348 0.1986 0.1977
Onchocerca volvulus 0.0387 0.2224 0.9645
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0707 0.1464
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0225 0.0215
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0111 0.0537 0.1854
Giardia lamblia Cysteine protease 0.0111 0.0537 0.094
Giardia lamblia Cathepsin L-like protease 0.0111 0.0537 0.094
Entamoeba histolytica protein kinase, putative 0.0138 0.0707 0.2611
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0707 0.1464
Echinococcus granulosus cathepsin L cysteine protease 0.0223 0.1221 0.1212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Schistosoma mansoni cathepsin B (C01 family) 0.0111 0.0537 0.0537
Giardia lamblia Cathepsin B precursor 0.0111 0.0537 0.094
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0225 0.0215
Echinococcus granulosus cathepsin b 0.1662 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.0537 0.0537
Plasmodium vivax vivapain-3 0.0223 0.1221 0.5157
Brugia malayi Papain family cysteine protease containing protein 0.0223 0.1221 0.1212
Toxoplasma gondii aurora kinase 0.0138 0.0707 0.0578
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0223 0.1221 0.1011
Brugia malayi serine/threonine kinase 12 0.0138 0.0707 0.0697
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0111 0.0537 0.1787
Echinococcus granulosus cathepsin l cysteine peptidase 0.0387 0.2224 0.2215
Echinococcus granulosus roundabout 2 0.0069 0.0285 0.0275
Echinococcus multilocularis protein tyrosine kinase 0.0319 0.1809 0.1801
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0537 0.0311
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0111 0.0537 0.0537
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1662 1 1
Loa Loa (eye worm) AUR protein kinase 0.0138 0.0707 0.0707
Schistosoma mansoni tyrosine kinase 0.0348 0.1986 0.1986
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0156
Schistosoma mansoni cathepsin S (C01 family) 0.0111 0.0537 0.0537
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0225 0.0215
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0443 0.2567 0.2567
Brugia malayi Cathepsin L-like precursor 0.0275 0.154 0.1531
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0111 0.0537 0.1854
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Brugia malayi serine/threonine-protein kinase plk-2 0.0061 0.0234 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0537 0.094
Entamoeba histolytica cysteine protease, putative 0.0111 0.0537 0.1787
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1662 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0034 0.0024
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0111 0.0537 0.1854
Brugia malayi cathepsin F-like cysteine proteinase 0.0112 0.0547 0.0537
Loa Loa (eye worm) AUR protein kinase 0.0138 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0387 0.2224 0.2224
Echinococcus granulosus ephrin type A receptor 4 A 0.0097 0.0453 0.0443
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0154 0.0143
Echinococcus granulosus ryanodine receptor 44f 0.0116 0.0573 0.0563
Schistosoma mansoni cell adhesion molecule 0.006 0.0229 0.0229
Echinococcus multilocularis ephrin type A receptor 4 A 0.0097 0.0453 0.0443
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Echinococcus multilocularis cathepsin L 0.0223 0.1221 0.1212
Trypanosoma cruzi aurora B kinase, putative 0.0138 0.0707 0.0484
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0111 0.0537 0.1854
Brugia malayi Immunoglobulin I-set domain containing protein 0.0025 0.0013 0.0002
Entamoeba histolytica protein kinase , putative 0.0138 0.0707 0.2611
Loa Loa (eye worm) TK protein kinase 0.005 0.0171 0.0171
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0111 0.0537 0.1787
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0111 0.0537 0.094
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Trypanosoma cruzi cruzipain precursor, putative 0.0112 0.0547 0.0321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.1221 0.3056
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0537 0.094
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0156
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.059 0.3464 0.3464
Echinococcus granulosus cathepsin L 0.0223 0.1221 0.1212
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0111 0.0537 0.0537
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0011 0.0011
Brugia malayi Protein kinase domain containing protein 0.0442 0.2559 0.2551
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0041 0.0114 0.0104
Leishmania major protein kinase, putative 0.0138 0.0707 0.1708
Entamoeba histolytica cysteine protease, putative 0.0111 0.0537 0.1787
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0547 0.0321
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0111 0.0537 0.094
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0387 0.2224 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0068 0.0068
Echinococcus granulosus contactin 0.0028 0.0034 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0275 0.154 0.4044
Echinococcus multilocularis tyrosine protein kinase Blk 0.0055 0.0198 0.0188
Echinococcus multilocularis cathepsin b 0.1662 1 1
Brugia malayi hypothetical protein 0.0048 0.0156 0.0146
Plasmodium vivax vivapain-2 0.0387 0.2224 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0061 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0111 0.0537 0.094
Schistosoma mansoni tyrosine kinase 0.0515 0.3002 0.3002
Loa Loa (eye worm) ctsf protein 0.0387 0.2224 0.2224
Echinococcus multilocularis cathepsin L cysteine protease 0.0387 0.2224 0.2215
Giardia lamblia Cathepsin L precursor 0.0111 0.0537 0.094
Schistosoma mansoni lipoxygenase 0.0048 0.0154 0.0154
Echinococcus granulosus protein tyrosine kinase 0.0319 0.1809 0.1801
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0537 0.094
Entamoeba histolytica cysteine proteinase, putative 0.0223 0.1221 0.5116
Schistosoma mansoni protein kinase 0.0138 0.0707 0.0707
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0028 0.0034 0.0034
Schistosoma mansoni rab6-interacting 0.0048 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0111 0.0537 0.0537
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0387 0.2224 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0031 0.0053 0.0053
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0223 0.1221 0.1221
Giardia lamblia Cathepsin L precursor 0.0111 0.0537 0.094
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0106 0.0095
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0028 0.0034 0.0024
Brugia malayi Cathepsin L-like precursor 0.0387 0.2224 0.2215
Echinococcus granulosus neuroglian 0.0028 0.0034 0.0024
Brugia malayi Papain family cysteine protease containing protein 0.0111 0.0537 0.0527
Echinococcus multilocularis cathepsin L 0.0111 0.0537 0.0527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Loa Loa (eye worm) hypothetical protein 0.0275 0.154 0.154
Onchocerca volvulus Cathepsin L homolog 0.0387 0.2224 0.9645
Plasmodium falciparum serine repeat antigen 7 0.0111 0.0537 0.1854
Echinococcus multilocularis RUN 0.0048 0.0154 0.0143
Entamoeba histolytica cysteine protease, putative 0.0111 0.0537 0.1787
Brugia malayi Papain family cysteine protease containing protein 0.0111 0.0537 0.0527
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0154 0.0143
Echinococcus multilocularis Immunoglobulin 0.0041 0.0114 0.0104
Loa Loa (eye worm) TK protein kinase 0.0055 0.0198 0.0198
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0034 0.0024
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0106 0.0095
Schistosoma mansoni nephrin 0.0028 0.0034 0.0034
Brugia malayi cathepsin Z-like cysteine proteinase 0.0111 0.0537 0.0527
Brugia malayi cathepsin Z-like cysteine proteinase 0.0111 0.0537 0.0527
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0059 0.0225 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0537 0.094
Giardia lamblia Cathepsin B precursor 0.0111 0.0537 0.094
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0133 0.0676 0.0667
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0537 0.0311
Echinococcus multilocularis Immunoglobulin 0.0041 0.0114 0.0104
Giardia lamblia Cathepsin L precursor 0.0111 0.0537 0.094
Brugia malayi cathepsin F-like cysteine proteinase 0.0111 0.0537 0.0527
Giardia lamblia Hypothetical protein 0.0111 0.0537 0.094
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0138 0.0707 0.2672
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Loa Loa (eye worm) cathepsin B 0.059 0.3464 0.3464
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.0537 0.0537
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0223 0.1221 0.1221
Plasmodium falciparum cysteine proteinase falcipain 1 0.0223 0.1221 0.5157
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0056 0.0207 0.0207
Giardia lamblia Hypothetical protein 0.0111 0.0537 0.094
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0111 0.0537 0.1854
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0111 0.0537 0.1854
Brugia malayi cathepsin L-like precursor 0.0275 0.154 0.1531
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0055 0.0198 0.0188
Loa Loa (eye worm) doublecortin family protein 0.0048 0.0154 0.0154
Echinococcus multilocularis insulin receptor 0.0442 0.2559 0.2551
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0028 0.0034 0.0024
Echinococcus granulosus plexin a4 0.0025 0.0014 0.0003
Brugia malayi cathepsin L-like cysteine proteinase 0.0111 0.0537 0.0527
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0111 0.0537 0.094
Giardia lamblia Cathepsin B precursor 0.0111 0.0537 0.094
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0111 0.0537 0.1854
Schistosoma mansoni polycystin 1-related 0.0048 0.0154 0.0154
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0112 0.0547 0.0547
Brugia malayi Protein kinase domain containing protein 0.0188 0.1007 0.0998
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0225 0.0215
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0387 0.2224 0.2215
Loa Loa (eye worm) hypothetical protein 0.0041 0.0114 0.0114
Echinococcus granulosus tyrosine protein kinase Src64B 0.0059 0.0225 0.0215
Giardia lamblia Cathepsin L-like protease 0.0111 0.0537 0.094
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0387 0.2224 0.2224
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0111 0.0537 0.094
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0112 0.0547 0.0537
Schistosoma mansoni vesicular amine transporter 0.0042 0.0122 0.0122
Plasmodium falciparum serine repeat antigen 1 0.0111 0.0537 0.1854
Loa Loa (eye worm) hypothetical protein 0.0048 0.0154 0.0154
Brugia malayi Fibronectin type III domain containing protein 0.0048 0.0156 0.0146
Onchocerca volvulus 0.0375 0.215 0.9303
Echinococcus multilocularis aurora kinase A 0.0138 0.0707 0.0697
Schistosoma mansoni tyrosine kinase 0.0333 0.1893 0.1893
Entamoeba histolytica cysteine proteinase, putative 0.0223 0.1221 0.5116
Echinococcus granulosus cathepsin L 0.0111 0.0537 0.0527
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0275 0.154 0.4044
Giardia lamblia Cysteine protease 0.0111 0.0537 0.094
Entamoeba histolytica cysteine proteinase, putative 0.0223 0.1221 0.5116
Echinococcus granulosus twitchin 0.0054 0.019 0.018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0223 0.1221 0.3056
Loa Loa (eye worm) TK/EPH protein kinase 0.0099 0.0468 0.0468
Schistosoma mansoni tyrosine kinase 0.0059 0.0225 0.0225
Echinococcus granulosus roundabout 2 0.0028 0.0034 0.0024
Brugia malayi cation channel family protein 0.0079 0.0344 0.0334
Loa Loa (eye worm) TK/FAK protein kinase 0.0323 0.1831 0.1831
Echinococcus granulosus tyrosine protein kinase Lyn 0.0063 0.0245 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0111 0.0537 0.0527
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0111 0.0537 0.1854
Brugia malayi Papain family cysteine protease containing protein 0.0111 0.0537 0.0527
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0059 0.0225 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Echinococcus multilocularis cathepsin L cysteine protease 0.0387 0.2224 0.2215
Leishmania major cysteine peptidase A (CPA) 0.0387 0.2224 0.627
Giardia lamblia Cysteine protease 0.0111 0.0537 0.094
Echinococcus multilocularis ryanodine receptor 44f 0.0116 0.0573 0.0563
Onchocerca volvulus Cathepsin L homolog 0.0387 0.2224 0.9645
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.0591 0.3465 0.3465
Echinococcus granulosus RUN 0.0048 0.0154 0.0143
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0138 0.0707 0.2611
Echinococcus multilocularis epidermal growth factor receptor 0.0515 0.3002 0.2995
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0111 0.0537 0.0537
Entamoeba histolytica cysteine protease, putative 0.0111 0.0537 0.1787
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0034 0.0024
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0156 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.1221 0.3056
Loa Loa (eye worm) hypothetical protein 0.0066 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0077 0.0077
Onchocerca volvulus 0.0111 0.0537 0.1788
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0059 0.0225 0.0215
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0111 0.0537 0.094
Loa Loa (eye worm) hypothetical protein 0.0275 0.154 0.154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0041 0.0114 0.0114
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0061 0.0234 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Loa Loa (eye worm) hypothetical protein 0.0062 0.0244 0.0244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Echinococcus multilocularis tyrosine protein kinase Srms 0.0055 0.0198 0.0188
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Loa Loa (eye worm) hypothetical protein 0.0172 0.0915 0.0915
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0111 0.0537 0.0537
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0041 0.0114 0.0114
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0059 0.0225 0.0215
Trypanosoma cruzi cysteine peptidase, putative 0.0223 0.1221 0.1011
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0275 0.154 0.1338
Schistosoma mansoni cathepsin F (C01 family) 0.0387 0.2224 0.2224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0537 0.094
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0138 0.0707 0.2611
Onchocerca volvulus 0.0387 0.2224 0.9645
Schistosoma mansoni kinase 0.0195 0.1053 0.1053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0387 0.2224 0.2224
Brugia malayi Cathepsin L-like precursor 0.0112 0.0547 0.0537
Brugia malayi fibroinase precursor 0.0111 0.0537 0.0527
Entamoeba histolytica cysteine proteinase 1, putative 0.0223 0.1221 0.5116
Brugia malayi Immunoglobulin I-set domain containing protein 0.0443 0.2567 0.2559
Loa Loa (eye worm) hypothetical protein 0.0048 0.0154 0.0154
Plasmodium falciparum serine repeat antigen 6 0.0111 0.0537 0.1854
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0138 0.0702 0.0692
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Giardia lamblia Cathepsin L precursor 0.0111 0.0537 0.094
Echinococcus granulosus tyrosine kinase 0.0055 0.0198 0.0188
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0707 0.0707
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Trypanosoma cruzi cysteine peptidase, putative 0.0387 0.2224 0.2038
Schistosoma mansoni lipoxygenase 0.0133 0.0676 0.0676
Entamoeba histolytica cysteine protease, putative 0.0111 0.0537 0.1787
Entamoeba histolytica cysteine proteinase, putative 0.0387 0.2224 1
Schistosoma mansoni hypothetical protein 0.0045 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Echinococcus multilocularis roundabout 2 0.0028 0.0034 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0537 0.094
Schistosoma mansoni cell adhesion molecule 0.0028 0.0034 0.0034
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Brugia malayi Cathepsin L-like precursor 0.0387 0.2224 0.2215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0061 0.0234 0.0286
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Brugia malayi hypothetical protein 0.0048 0.0154 0.0143
Entamoeba histolytica cysteine proteinase, putative 0.0223 0.1221 0.5116
Schistosoma mansoni neuroglian 0.0028 0.0034 0.0034
Plasmodium vivax unspecified product 0.0111 0.0537 0.1854
Plasmodium falciparum serine repeat antigen 5 0.0111 0.0537 0.1854
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0537 0.094
Brugia malayi Cathepsin L-like precursor 0.0387 0.2224 0.2215
Echinococcus granulosus epidermal growth factor receptor 0.0348 0.1986 0.1977
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0111 0.0537 0.0537
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0133 0.0676 0.0667
Giardia lamblia Cathepsin B precursor 0.0111 0.0537 0.094
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0028 0.0034 0.0024
Echinococcus granulosus cathepsin b 0.1662 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Loa Loa (eye worm) TK/EGFR protein kinase 0.0515 0.3002 0.3002
Schistosoma mansoni tyrosine kinase 0.0024 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0112 0.0547 0.0547
Loa Loa (eye worm) AUR protein kinase 0.0138 0.0707 0.0707
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Schistosoma mansoni tyrosine kinase 0.0024 0.0011 0.0011
Brugia malayi Cathepsin L-like precursor 0.0275 0.154 0.1531
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Entamoeba histolytica cysteine protease, putative 0.0111 0.0537 0.1787
Onchocerca volvulus 0.0387 0.2224 0.9645
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0138 0.0707 0.0697
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0154 0.0143
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.0154 0.0143
Onchocerca volvulus Cathepsin F homolog 0.0387 0.2224 0.9645
Brugia malayi ephrin receptor 1 precursor 0.0046 0.0145 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.0537 0.0537
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0055 0.0198 0.0188
Plasmodium vivax vivapain-1 0.0223 0.1221 0.5157
Brugia malayi serine/threonine protein kinase 6 0.0138 0.0707 0.0697
Echinococcus granulosus ryanodine receptor 44f 0.0149 0.0773 0.0764
Giardia lamblia Cathepsin B precursor 0.059 0.3464 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0537 0.094
Brugia malayi Protein kinase domain containing protein 0.0323 0.1831 0.1823
Trypanosoma cruzi cysteine proteinase, putative 0.0223 0.1221 0.1011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0138 0.0702 0.0692
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0111 0.0537 0.0537
Schistosoma mansoni cathepsin C 0.0111 0.0537 0.0537
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0138 0.0707 0.0697
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.0013 0.0002
Schistosoma mansoni tyrosine kinase 0.0348 0.1986 0.1986
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0061 0.0234 0.0223
Brugia malayi Doublecortin family protein 0.0048 0.0154 0.0143
Loa Loa (eye worm) cysteine protease 0.0387 0.2224 0.2224
Echinococcus granulosus cathepsin l1 0.0387 0.2224 0.2215
Entamoeba histolytica protein kinase domain containing protein 0.0138 0.0707 0.2611
Trypanosoma brucei cysteine peptidase C (CPC) 0.059 0.3464 1
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Schistosoma mansoni tyrosine kinase 0.0059 0.0225 0.0225
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.0013 0.0002
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1662 1 1
Echinococcus multilocularis tyrosine protein kinase HCK 0.005 0.0171 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0111 0.0537 0.094
Schistosoma mansoni tyrosine kinase 0.0442 0.2559 0.2559
Brugia malayi Cathepsin L-like precursor 0.0387 0.2224 0.2215
Giardia lamblia Aurora kinase 0.0138 0.0707 0.1464
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0034
Plasmodium vivax vivapain-2 0.0387 0.2224 1
Echinococcus granulosus neuroglian 0.0051 0.0171 0.0161
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Onchocerca volvulus 0.0387 0.2224 0.9645
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0111 0.0537 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Entamoeba histolytica cysteine proteinase, putative 0.0275 0.154 0.667
Brugia malayi plexin A 0.0025 0.0014 0.0003
Plasmodium falciparum serine/threonine protein kinase, putative 0.0138 0.0707 0.2672
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Echinococcus multilocularis roundabout 2 0.0069 0.0285 0.0275
Loa Loa (eye worm) plexin A 0.0025 0.0014 0.0014
Giardia lamblia Cathepsin B precursor 0.059 0.3464 1
Echinococcus multilocularis cathepsin b 0.1662 1 1
Brugia malayi cathepsin L precursor 0.0111 0.0537 0.0527
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0348 0.1986 0.1977
Schistosoma mansoni cathepsin s 0.0112 0.0547 0.0547
Schistosoma mansoni nephrin 0.0057 0.0213 0.0213
Schistosoma mansoni loxhd1 0.0048 0.0154 0.0154
Plasmodium falciparum serine repeat antigen 2 0.0111 0.0537 0.1854
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.059 0.3464 1
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Echinococcus multilocularis cysteine protease 0.0387 0.2224 0.2215
Loa Loa (eye worm) hypothetical protein 0.0111 0.0537 0.0537
Echinococcus multilocularis cysteine protease 0.0387 0.2224 0.2215
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0138 0.0707 0.2611
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.059 0.3464 0.3308
Schistosoma mansoni hypothetical protein 0.0048 0.0154 0.0154
Echinococcus multilocularis ryanodine receptor 44f 0.0149 0.0773 0.0764
Echinococcus granulosus epidermal growth factor receptor 0.0515 0.3002 0.2995
Plasmodium vivax unspecified product 0.0112 0.0547 0.1899
Trypanosoma cruzi cysteine peptidase, putative 0.0387 0.2224 0.2038
Echinococcus granulosus tyrosine protein kinase HCK 0.005 0.0171 0.016
Echinococcus granulosus defective proboscis extension response 0.0041 0.0114 0.0104
Plasmodium falciparum serine repeat antigen 9 0.0111 0.0537 0.1854
Onchocerca volvulus Tyrosine kinase homolog 0.04 0.23 1
Giardia lamblia Encystation-specific protease 0.0111 0.0537 0.094
Plasmodium vivax unspecified product 0.0223 0.1221 0.5157
Echinococcus multilocularis neuroglian 0.0051 0.0171 0.0161
Schistosoma mansoni cathepsin F (C01 family) 0.0275 0.154 0.154
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0154 0.0143
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0387 0.2224 0.616
Brugia malayi Papain family cysteine protease containing protein 0.0223 0.1221 0.1212
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0111 0.0537 0.1854
Echinococcus multilocularis neuroglian 0.0028 0.0034 0.0024
Plasmodium falciparum serine repeat antigen 4 0.0111 0.0537 0.1854
Onchocerca volvulus 0.0387 0.2224 0.9645
Brugia malayi Cathepsin L-like cysteine proteinase 0.0275 0.154 0.1531
Leishmania major cathepsin L-like protease 0.0387 0.2224 0.627
Schistosoma mansoni ryanodine receptor related 0.0184 0.0987 0.0987
Entamoeba histolytica serine/threonine protein kinase, putative 0.0061 0.0234 0.0308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0449 0.26 0.2593
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0184 0.0987 0.0978
Loa Loa (eye worm) ryanodine receptor 0.0043 0.0128 0.0128
Echinococcus granulosus aurora kinase A 0.0138 0.0707 0.0697
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0059 0.0225 0.0215
Loa Loa (eye worm) hypothetical protein 0.0062 0.0244 0.0244
Loa Loa (eye worm) TK/INSR protein kinase 0.0442 0.2559 0.2559
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0387 0.2224 0.616
Echinococcus granulosus insulin receptor 0.0442 0.2559 0.2551
Onchocerca volvulus 0.0387 0.2224 0.9645
Loa Loa (eye worm) hypothetical protein 0.0053 0.0187 0.0187
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0059 0.0225 0.0215
Loa Loa (eye worm) hypothetical protein 0.0048 0.0156 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0387 0.2224 0.616
Plasmodium falciparum serine repeat antigen 8 0.0111 0.0537 0.1854
Brugia malayi Cathepsin L-like precursor 0.0387 0.2224 0.2215
Trypanosoma cruzi cysteine protease, putative 0.0223 0.1221 0.1011
Entamoeba histolytica protein kinase, putative 0.0138 0.0707 0.2611
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Schistosoma mansoni rab6-interacting 0.0048 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0038 0.0094 0.0094
Plasmodium vivax serine-repeat antigen (SERA) 0.0111 0.0537 0.1854
Echinococcus multilocularis roundabout 2 0.0028 0.0034 0.0024
Schistosoma mansoni ephrin receptor 0.0081 0.0358 0.0358
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0111 0.0537 0.094
Loa Loa (eye worm) hypothetical protein 0.0112 0.0547 0.0547
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0111 0.0537 0.0537
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0111 0.0537 0.1854
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1662 1 1
Brugia malayi Cathepsin L-like precursor 0.0387 0.2224 0.2215
Brugia malayi SRC-1 0.0059 0.0225 0.0215
Loa Loa (eye worm) hypothetical protein 0.0112 0.0547 0.0547
Plasmodium falciparum serine repeat antigen 3 0.0111 0.0537 0.1854
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0066 0.0268 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0223 0.1221 0.3056
Schistosoma mansoni cell adhesion molecule 0.0028 0.0034 0.0034
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0387 0.2224 0.2215
Schistosoma mansoni tyrosine kinase 0.0333 0.1893 0.1893
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0111 0.0537 0.0537
Trypanosoma cruzi cysteine peptidase, putative 0.0387 0.2224 0.2038
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0111 0.0537 0.094
Loa Loa (eye worm) ryanodine receptor 0.0069 0.0283 0.0283
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0059 0.0225 0.0215
Schistosoma mansoni cathepsin F (C01 family) 0.0387 0.2224 0.2224
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0225 0.0215
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0223 0.1221 0.1221
Loa Loa (eye worm) hypothetical protein 0.0041 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0537 0.094
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0111 0.0537 0.094
Trypanosoma cruzi cysteine proteinase, putative 0.0223 0.1221 0.1011
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0066 0.0268 0.0108
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0028 0.0034 0.0024
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0053 0.0187 0.0177
Brugia malayi protein-tyrosine kinase 0.0055 0.0198 0.0188
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0387 0.2224 0.616
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0387 0.2224 0.616
Toxoplasma gondii cathepsin B 0.059 0.3464 1
Giardia lamblia Cathepsin L precursor 0.0111 0.0537 0.094
Plasmodium falciparum cysteine proteinase falcipain 3 0.0387 0.2224 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0111 0.0537 0.094
Entamoeba histolytica cysteine protease, putative 0.0223 0.1221 0.5116
Schistosoma mansoni tyrosine kinase 0.0036 0.0085 0.0085
Onchocerca volvulus 0.0275 0.154 0.646
Onchocerca volvulus 0.0066 0.0265 0.0519
Echinococcus multilocularis 0.0153 0.0795 0.0785
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0059 0.0225 0.0215
Entamoeba histolytica cysteine proteinase, putative 0.0387 0.2224 1
Toxoplasma gondii cathepsin CPL 0.0387 0.2224 0.5762
Brugia malayi Furin-like cysteine rich region family protein 0.0515 0.3002 0.2995
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0111 0.0537 0.1854
Loa Loa (eye worm) SRC-1 0.0059 0.0225 0.0225
Brugia malayi hypothetical protein 0.0048 0.0154 0.0143
Entamoeba histolytica hypothetical protein 0.0111 0.0537 0.1787
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0111 0.0537 0.094
Loa Loa (eye worm) hypothetical protein 0.0275 0.154 0.154
Loa Loa (eye worm) hypothetical protein 0.0111 0.0537 0.0537
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0234 0.0234
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0225 0.0215
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0111 0.0537 0.1854

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antitrypanosomal activity against Trypanosoma brucei brucei 221 after 48 hrs by ATP-bioluminescence assay ChEMBL. 20102170
Activity (functional) = 37.3 % Antiangiogenic activity in HUVEC cells assessed as inhibition of hEGF-induced tubular formation at 1 ug/mL after 24 hrs relative to control ChEMBL. 18298075
Activity (functional) = 37.3 % Antiangiogenic activity in HUVEC cells assessed as inhibition of hEGF-induced tubular formation at 1 ug/mL after 24 hrs relative to control ChEMBL. 18298075
cLogP (ADMET) = 10.21 Hydrophobicity ChEMBL. 15267244
EC50 (binding) = 6.3 uM Binding affinity to RYR1 channels by calcium mobilization assay ChEMBL. 18851910
IC50 (functional) = 0.054 uM Antiproliferative activity against bFGF-treated HUVEC ChEMBL. No reference
IC50 (binding) = 1.3 uM Inhibition of VEGFR2 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.5 uM Inhibition of EGFR (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.7 uM Inhibition of IGF1R (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.8 uM Inhibition of TIE2 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 1.9 uM Inhibition of SAK (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2 uM Inhibition of SRC (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.3 uM Inhibitory effect on human platelet 12-lipoxygenase ChEMBL. 15267244
IC50 (binding) = 2.3 uM Inhibitory effect on human platelet 12-lipoxygenase ChEMBL. 15267244
IC50 (binding) = 2.6 uM Inhibition of aurora-B (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.6 uM Inhibition of CDK4/cyclin-D1 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.8 uM Inhibition of ERBB2 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.8 uM Inhibition of MET (unknown origin) ChEMBL. 23249297
IC50 (binding) = 2.9 uM Inhibition of FLT3 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 3.2 uM Inhibition of ARK5 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 3.2 uM Inhibition of VEGFR3 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 3.3 uM Inhibition of COT (unknown origin) ChEMBL. 23249297
IC50 (binding) = 3.9 uM Inhibition of aurora-A (unknown origin) ChEMBL. 23249297
IC50 (binding) = 4 uM Inhibitory effect on human reticulocyte 15-lipoxygenase ChEMBL. 15267244
IC50 (binding) = 4 uM Inhibitory effect on human reticulocyte 15-lipoxygenase ChEMBL. 15267244
IC50 (binding) = 4.4 uM Inhibition of INSR (unknown origin) ChEMBL. 23249297
IC50 (functional) = 5.3 uM Cytotoxicity against mouse L5178Y cells assessed as inhibition of cell proliferation by MTT assay ChEMBL. 23249297
IC50 (binding) = 7.3 uM Inhibition of FAK (unknown origin) ChEMBL. 23249297
IC50 (binding) = 7.7 uM Inhibition of EPHB4 (unknown origin) ChEMBL. 23249297
IC50 (binding) = 10.2 uM Inhibition of PDGFR-beta (unknown origin) ChEMBL. 23249297
IC50 (binding) = 27 uM Inhibitory effect on soybean 15-lipoxygenase ChEMBL. 15267244
Inhibition (binding) Inhibition of human ACAT1 expressed in CHO cells assessed as inhibition of [3H]cholesterol ester accumulation at 5 uM in presence of 0.1 mM [3H]oleate-conjugated BSA ChEMBL. 26403929
Inhibition (binding) Inhibition of human ACAT2 expressed in CHO cells assessed as inhibition of [3H]cholesterol ester accumulation at 5 uM in presence of 0.1 mM [3H]oleate-conjugated BSA ChEMBL. 26403929

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 23249297
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

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