Detailed information for compound 344401

Basic information

Technical information
  • TDR Targets ID: 344401
  • Name: 3-[2-(4-benzoylpiperazin-1-yl)ethyl]-6-(3-eth yl-4-methylanilino)-1H-pyrimidine-2,4-dione
  • MW: 461.556 | Formula: C26H31N5O3
  • H donors: 2 H acceptors: 3 LogP: 3.09 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cc(ccc1C)Nc1cc(=O)n(c(=O)[nH]1)CCN1CCN(CC1)C(=O)c1ccccc1
  • InChi: 1S/C26H31N5O3/c1-3-20-17-22(10-9-19(20)2)27-23-18-24(32)31(26(34)28-23)16-13-29-11-14-30(15-12-29)25(33)21-7-5-4-6-8-21/h4-10,17-18,27H,3,11-16H2,1-2H3,(H,28,34)
  • InChiKey: YLTNZSAWERXYOE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[2-(4-benzoylpiperazin-1-yl)ethyl]-6-(3-ethyl-4-methyl-anilino)-1H-pyrimidine-2,4-dione
  • 3-[2-(4-benzoyl-1-piperazinyl)ethyl]-6-(3-ethyl-4-methylanilino)-1H-pyrimidine-2,4-dione
  • 6-[(3-ethyl-4-methyl-phenyl)amino]-3-[2-[4-(phenylcarbonyl)piperazin-1-yl]ethyl]-1H-pyrimidine-2,4-dione
  • 3-[2-(4-benzoylpiperazino)ethyl]-6-(3-ethyl-4-methyl-anilino)uracil
  • 3-[2-[4-(benzoyl)piperazin-1-yl]ethyl]-6-[(3-ethyl-4-methylphenyl)amino]-1H-pyrimidine-2,4-dione
  • 3-[2-[4-(benzoyl)piperazin-1-yl]ethyl]-6-[(3-ethyl-4-methyl-phenyl)amino]-1H-pyrimidine-2,4-dione
  • 6-[(3-ethyl-4-methylphenyl)amino]-3-[2-[4-(oxo-phenylmethyl)-1-piperazinyl]ethyl]-1H-pyrimidine-2,4-dione
  • 3-[2-[4-(benzoyl)piperazin-1-yl]ethyl]-6-[(3-ethyl-4-methyl-phenyl)amino]uracil
  • 6-[(3-ethyl-4-methyl-phenyl)amino]-3-[2-(4-phenylcarbonylpiperazin-1-yl)ethyl]-1H-pyrimidine-2,4-dione

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) DNA polymerase III Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0072 0.0071
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0096 0.0141
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0091 0.0123
Brugia malayi conserved hypotetical protein 0.0029 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Brugia malayi jmjC domain containing protein 0.002 0.0007 0.0001
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0295 0.0302
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0034 0.0105 0.0143
Treponema pallidum fructose-bisphosphate aldolase 0.1204 0.7995 1
Echinococcus multilocularis muscleblind protein 0.015 0.0883 0.1297
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0135 0.0188
Brugia malayi Pax transcription factor protein 2 0.0267 0.1676 0.1799
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0072 0.0069
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0072 0.0106
Entamoeba histolytica hypothetical protein 0.0219 0.1354 0.1404
Entamoeba histolytica transcription factor BTF3, putative 0.0039 0.0135 0.0127
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0219 0.1354 0.1989
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0072 0.0106
Toxoplasma gondii histone lysine methyltransferase SET1 0.0115 0.0649 0.212
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0234 0.145 0.2257
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0056 0.0053
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0202 0.1234 0.1813
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0014 0.0025
Entamoeba histolytica hypothetical protein 0.0219 0.1354 0.1404
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0072 0.0106
Loa Loa (eye worm) hypothetical protein 0.0072 0.0359 0.0387
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0103 0.0572 0.084
Brugia malayi nuclear receptor NHR-88 0.0029 0.0072 0.0071
Loa Loa (eye worm) steroid hormone receptor 0.0063 0.0295 0.0318
Echinococcus granulosus lysine specific demethylase 5A 0.0078 0.0399 0.0587
Mycobacterium ulcerans hypothetical protein 0.0049 0.0201 0.0187
Brugia malayi nuclear hormone receptor 0.0063 0.0295 0.0311
Brugia malayi N-terminal motif family protein 0.02 0.1225 0.1313
Brugia malayi hypothetical protein 0.0033 0.0096 0.0097
Schistosoma mansoni jumonji domain containing protein 0.016 0.0954 0.0993
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0123 0.0701 0.0755
Echinococcus multilocularis geminin 0.0335 0.2136 0.3139
Echinococcus multilocularis peregrin 0.0062 0.0289 0.0424
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1434 0.9551 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0063 0.0295 0.0311
Echinococcus granulosus peregrin 0.0062 0.0289 0.0424
Brugia malayi Kringle domain containing protein 0.003 0.0077 0.0076
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Schistosoma mansoni Smad4 0.0025 0.0042 0.0037
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0024 0.0034 0.0091
Loa Loa (eye worm) hypothetical protein 0.0105 0.0584 0.0629
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0068 0.0329 0.1065
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0812 0.5351 0.7864
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0063 0.0295 0.0311
Echinococcus granulosus carbonic anhydrase 0.0468 0.3031 0.4454
Entamoeba histolytica cyclin-dependent kinase regulatory subunit, putative 0.0033 0.0096 0.0085
Echinococcus granulosus ecdysone induced protein 78C 0.0063 0.0295 0.0434
Toxoplasma gondii cyclin-dependent kinase regulatory subunit protein 0.0033 0.0096 0.0292
Loa Loa (eye worm) hypothetical protein 0.0085 0.0448 0.0482
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0103 0.0572 0.083
Schistosoma mansoni hypothetical protein 0.0033 0.0098 0.0096
Schistosoma mansoni hypothetical protein 0.002 0.0009 0.0003
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1027 0.6805 1
Schistosoma mansoni hypothetical protein 0.0033 0.0098 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0295 0.0311
Onchocerca volvulus 0.0029 0.0072 0.0071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0063 0.0295 0.0434
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0014 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.0731 0.0787
Echinococcus granulosus neuropeptide s receptor 0.0475 0.308 0.4527
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0091 0.0077
Echinococcus granulosus carbonic anhydrase 0.0468 0.3031 0.4454
Schistosoma mansoni carbonic anhydrase-related 0.0468 0.3031 0.3169
Onchocerca volvulus 0.0492 0.319 0.3431
Brugia malayi nuclear receptor RXR 0.0033 0.0096 0.0097
Loa Loa (eye worm) cyclin-dependent kinase regulatory subunit 0.0033 0.0096 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0063 0.0295 0.0311
Giardia lamblia PHD finger protein 15 0.0062 0.0289 0.0344
Loa Loa (eye worm) hypothetical protein 0.0027 0.0052 0.0056
Echinococcus granulosus carbonic anhydrase II 0.1027 0.6805 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0038
Schistosoma mansoni hypothetical protein 0.0219 0.1354 0.1411
Echinococcus granulosus cpg binding protein 0.0064 0.0306 0.045
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0007 0.0008
Onchocerca volvulus 0.0061 0.0283 0.0297
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0044 0.0591
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0399 0.0412
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0063 0.0295 0.0434
Echinococcus multilocularis Protein lozenge 0.0062 0.0289 0.0425
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0007 0.001
Mycobacterium leprae PROBABLE DNA POLYMERASE III (ALPHA CHAIN) DNAE1 (DNA NUCLEOTIDYLTRANSFERASE) 0.0258 0.1616 0.0205
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0007 0.0011
Echinococcus granulosus RUN 0.002 0.0007 0.001
Schistosoma mansoni nuclear receptor 0.0029 0.0072 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0295 0.0434
Echinococcus granulosus intermediate filament protein 0.0027 0.0056 0.0082
Plasmodium falciparum basic transcription factor 3b, putative 0.0039 0.0135 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0063 0.0295 0.0311
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0056 0.006
Echinococcus multilocularis carbonic anhydrase II 0.1027 0.6805 1
Trypanosoma cruzi cyclin-dependent kinases regulatory subunit, putative 0.0033 0.0096 0.013
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0072 0.0106
Schistosoma mansoni transcription factor btf3 0.0039 0.0135 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0135 0.0121
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0072 0.0069
Echinococcus granulosus cyclin dependent kinases regulatory subunit 0.0033 0.0096 0.0141
Brugia malayi AF-10 protein 0.002 0.0009 0.0003
Brugia malayi hypothetical protein 0.0025 0.0044 0.004
Brugia malayi steroid hormone receptor 0.0063 0.0295 0.0311
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0584 0.0622
Brugia malayi hypothetical protein 0.0029 0.0072 0.0071
Trypanosoma brucei cyclin dependent kinases regulatory subunit, putative 0.0033 0.0096 0.013
Loa Loa (eye worm) hypothetical protein 0.0468 0.3031 0.3265
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1027 0.6805 0.7122
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0408 0.2629 0.3857
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.0295 0.0311
Echinococcus multilocularis Smad4 0.0025 0.0042 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0063 0.0295 0.0311
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0295 0.0311
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0091 0.0278
Plasmodium vivax JmjC domain containing protein 0.002 0.0007 0.0013
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0063 0.0295 0.0434
Brugia malayi Protein kinase domain containing protein 0.003 0.0077 0.0076
Echinococcus multilocularis thyroid hormone receptor alpha 0.0063 0.0295 0.0434
Schistosoma mansoni transcription factor LCR-F1 0.0219 0.1354 0.1411
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0113 0.0634 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.1501 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0367 0.2353 0.2534
Echinococcus granulosus geminin 0.0335 0.2136 0.3139
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0408 0.2629 0.2831
Schistosoma mansoni carbonic anhydrase 0.0468 0.3031 0.3169
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0009 0.0002
Schistosoma mansoni hypothetical protein 0.0335 0.2136 0.2231
Entamoeba histolytica hypothetical protein 0.0219 0.1354 0.1404
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0104
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.0063 0.0295 0.0311
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0072 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0295 0.0311
Onchocerca volvulus Alhambra homolog 0.0062 0.0289 0.0304
Schistosoma mansoni ap endonuclease 0.0021 0.0014 0.0008
Brugia malayi Smad1 0.0025 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0104
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE2 (DNA nucleotidyltransferase) 0.0258 0.1616 0.2518
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Schistosoma mansoni hypothetical protein 0.0335 0.2136 0.2231
Onchocerca volvulus 0.0151 0.0895 0.0957
Echinococcus granulosus nuclear factor of activated T cells 5 0.0318 0.2023 0.2972
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0408 0.2629 0.3857
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0103 0.0572 0.0698
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0063 0.0295 0.0434
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0007 0.0008
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0289 0.0311
Entamoeba histolytica hypothetical protein 0.0039 0.0135 0.0127
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0063 0.0295 0.0302
Brugia malayi beta-NAC-like protein 0.0039 0.0135 0.0139
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0063 0.0295 0.0311
Onchocerca volvulus 0.0267 0.1676 0.1799
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Brugia malayi hypothetical protein 0.0123 0.0701 0.0749
Leishmania major hypothetical protein, conserved 0.0025 0.0044 0.0038
Schistosoma mansoni lipoxygenase 0.0118 0.067 0.0695
Brugia malayi nuclear receptor NHR-67 0.0029 0.0072 0.0071
Brugia malayi Cyclin-dependent kinases regulatory subunit 0.0033 0.0096 0.0096
Leishmania major basic transcription factor 3a, putative 0.0039 0.0135 0.0134
Onchocerca volvulus Huntingtin homolog 0.0123 0.0701 0.0749
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.02 0.1225 0.1313
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0072 0.0071
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0108 0.0599 0.0645
Echinococcus multilocularis phd:f box containing protein 0.002 0.0007 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0044 0.012
Loa Loa (eye worm) runx1 0.0062 0.0289 0.0312
Echinococcus multilocularis microtubule associated protein 2 0.0691 0.4537 0.6667
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.0295 0.0434
Echinococcus multilocularis lamin 0.0027 0.0056 0.0082
Schistosoma mansoni lamin 0.0027 0.0056 0.0051
Mycobacterium ulcerans DNA polymerase III subunit alpha 0.0257 0.1607 0.1595
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0289 0.0424
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0295 0.0434
Echinococcus multilocularis muscleblind protein 1 0.015 0.0883 0.1297
Echinococcus multilocularis cpg binding protein 0.0064 0.0306 0.045
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0072 0.0071
Schistosoma mansoni carbonic anhydrase-related 0.0468 0.3031 0.3169
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0014 0.0021
Brugia malayi nuclear receptor RXR 0.0029 0.0072 0.0071
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0468 0.3031 0.326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0063 0.0295 0.0318
Plasmodium vivax sulfate transporter, putative 0.0032 0.0091 0.1343
Brugia malayi hypothetical protein 0.0029 0.0072 0.0071
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0007 0.0011
Brugia malayi jmjC domain containing protein 0.002 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0492 0.319 0.3436
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0072 0.0071
Brugia malayi CXXC zinc finger family protein 0.0061 0.0283 0.0297
Loa Loa (eye worm) hypothetical protein 0.015 0.0883 0.0951
Mycobacterium tuberculosis Probable DNA polymerase III (alpha chain) DnaE1 (DNA nucleotidyltransferase) 0.0258 0.1616 0.2518
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0408 0.2629 0.3857
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0135 0.0121
Schistosoma mansoni hypothetical protein 0.0468 0.3031 0.3169
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0295 0.0311
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0964 0.6376 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0201 0.0294
Echinococcus multilocularis lamin dm0 0.0027 0.0056 0.0082
Onchocerca volvulus 0.0027 0.0056 0.0053
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0007 0.001
Loa Loa (eye worm) ICD-1 protein 0.0039 0.0135 0.0146
Schistosoma mansoni nuclear receptor 0.0029 0.0072 0.0069
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0408 0.2629 0.2747
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0072 0.0071
Loa Loa (eye worm) hypothetical protein 0.0106 0.0585 0.0631
Brugia malayi jmjC domain containing protein 0.0202 0.1234 0.1323
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0113 0.0634 0.0621
Loa Loa (eye worm) hypothetical protein 0.02 0.1225 0.132
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0007 0.0011
Echinococcus multilocularis lysine specific demethylase 5A 0.0074 0.0376 0.0553
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0289 0.093
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0134 0.0137
Onchocerca volvulus 0.0063 0.0295 0.0311
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0072 0.0106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0584 0.0629
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0588 0.3841 0.6015
Onchocerca volvulus Bile acid receptor homolog 0.0063 0.0295 0.0311
Mycobacterium ulcerans error-prone DNA polymerase 0.0257 0.1607 0.1595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0063 0.0295 0.0318
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0063 0.0295 0.0311
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0044 0.0053
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0103 0.0572 0.3171
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0072 0.0078
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.0295 0.0434
Plasmodium vivax basic transcription factor 3b, putative 0.0039 0.0135 0.205
Onchocerca volvulus Huntingtin homolog 0.0123 0.0701 0.0749
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0103 0.0572 0.0616
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.0634 1
Schistosoma mansoni zinc finger protein 0.0029 0.0072 0.0069
Plasmodium vivax cysteine repeat modular protein 1, putative 0.003 0.0077 0.1126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0098 0.0144
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Echinococcus multilocularis carbonic anhydrase 0.0468 0.3031 0.4454
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0014 0.001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0129 0.0741 0.077
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0588 0.3841 0.3832
Loa Loa (eye worm) TK/ROR protein kinase 0.003 0.0077 0.0083
Leishmania major carbonic anhydrase family protein, putative 0.1434 0.9551 1
Entamoeba histolytica carbonic anhydrase, putative 0.1434 0.9551 1
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0103 0.0572 0.083
Brugia malayi ecdysteroid receptor 0.0063 0.0295 0.0311
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0468 0.3031 0.326
Echinococcus granulosus transcription factor Dp 1 0.0236 0.1468 0.2158
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0113 0.0634 0.0621
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0063 0.0295 0.0311
Brugia malayi intermediate filament protein 0.0027 0.0056 0.0053
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0063 0.0295 0.0302
Schistosoma mansoni carbonic anhydrase-related 0.0468 0.3031 0.3169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0063 0.0295 0.0318
Loa Loa (eye worm) hypothetical protein 0.0123 0.0701 0.0755
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0096 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0295 0.0311
Loa Loa (eye worm) hypothetical protein 0.0033 0.0098 0.0106
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1027 0.6805 0.7329
Brugia malayi Bromodomain containing protein 0.0062 0.0289 0.0304
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1027 0.6805 0.7327
Toxoplasma gondii hypothetical protein 0.0468 0.3031 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.0035
Brugia malayi MH2 domain containing protein 0.0025 0.0042 0.0038
Loa Loa (eye worm) Smad1 0.0025 0.0042 0.0046
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0295 0.0434
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0072 0.0071
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1204 0.7995 0.8368
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0295 0.0434
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0283 0.0304
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0318 0.2023 0.2972
Schistosoma mansoni jumonji domain containing protein 0.002 0.0007 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0063 0.0295 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0077 0.0103
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0091 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0063 0.0295 0.0318
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0096 0.0094
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0098 0.0099
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0072 0.0071
Loa Loa (eye worm) pax transcription factor protein 2 0.0267 0.1676 0.1805
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0031 0.0045
Echinococcus multilocularis transcription factor btf3 0.0039 0.0135 0.0199
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0044 0.0047
Entamoeba histolytica hypothetical protein 0.0219 0.1354 0.1404
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0202 0.1234 0.1813
Schistosoma mansoni eyes absent homolog 0.0085 0.0448 0.0462
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0289 0.093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Schistosoma mansoni microtubule-associated protein tau 0.0691 0.4537 0.4746
Echinococcus granulosus carbonic anhydrase 0.0468 0.3031 0.4454
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0072 0.0078
Onchocerca volvulus 0.1395 0.9285 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0468 0.3031 0.326
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0468 0.3031 0.326
Loa Loa (eye worm) hypothetical protein 0.0085 0.0448 0.0482
Loa Loa (eye worm) hypothetical protein 0.0468 0.3031 0.3265
Onchocerca volvulus 0.0033 0.0096 0.0096
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0063 0.0295 0.0434
Schistosoma mansoni smad 0.0025 0.0042 0.0037
Brugia malayi hypothetical protein 0.0033 0.0096 0.0097
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0037
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0042 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0063 0.0295 0.0318
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0408 0.2629 0.3863
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0289 0.0296
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0295 0.0311
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0098 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0034 0.0438
Schistosoma mansoni hypothetical protein 0.003 0.0077 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Mycobacterium ulcerans carbonic anhydrase 0.1434 0.9551 0.9551
Brugia malayi tailless protein 0.0029 0.0072 0.0071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0063 0.0295 0.0302
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Schistosoma mansoni cpg binding protein 0.0064 0.0306 0.0313
Onchocerca volvulus Putative sulfate transporter 0.0202 0.1239 0.1328
Brugia malayi jmjC domain containing protein 0.002 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0295 0.0302
Loa Loa (eye worm) hypothetical protein 0.0108 0.0599 0.0645
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0007 0.0011
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0042 0.0037
Trypanosoma cruzi cyclin-dependent kinases regulatory subunit, putative 0.0033 0.0096 0.013
Brugia malayi hypothetical protein 0.0492 0.319 0.3431
Leishmania major carbonic anhydrase-like protein 0.1027 0.6805 0.7122
Echinococcus multilocularis tissue type plasminogen activator 0.003 0.0077 0.0114
Plasmodium falciparum cysteine repeat modular protein 1 0.003 0.0077 0.0233
Brugia malayi PHD-finger family protein 0.0024 0.0032 0.0028
Brugia malayi MH2 domain containing protein 0.0367 0.2353 0.2528
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0063 0.0295 0.0302
Echinococcus multilocularis transcription factor eb 0.0108 0.0603 0.0886
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0408 0.2629 0.3863
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1027 0.6805 0.7327
Brugia malayi PHD-finger family protein 0.0062 0.0289 0.0304
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0014 0.0021
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0033 0.0098 0.0133
Loa Loa (eye worm) hypothetical protein 0.0468 0.3031 0.3265
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0042 0.0046
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.308 0.4527
Schistosoma mansoni hypothetical protein 0.0033 0.0098 0.0096
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0091 0.0276
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0072 0.0069
Giardia lamblia Fructose-bisphosphate aldolase 0.1204 0.7995 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0042 0.0046
Treponema pallidum DNA polymerase III subunit alpha 0.0257 0.1607 0.1996
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0103 0.0572 0.0592
Loa Loa (eye worm) hypothetical protein 0.1395 0.9285 1
Brugia malayi MH1 domain containing protein 0.0025 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Echinococcus granulosus phd:f box containing protein 0.002 0.0007 0.0011
Schistosoma mansoni ap endonuclease 0.0021 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0104
Echinococcus granulosus microtubule associated protein 2 0.0691 0.4537 0.6667
Schistosoma mansoni lamin 0.0027 0.0056 0.0051
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0042 0.0062
Schistosoma mansoni smad1 5 8 and 0.0025 0.0042 0.0037
Schistosoma mansoni hypothetical protein 0.0033 0.0096 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0098 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0367 0.2353 0.2534
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0007 0.0011
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0289 0.0424
Echinococcus multilocularis smad 0.0025 0.0042 0.0062
Schistosoma mansoni carbonic anhydrase 0.1434 0.9551 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0104
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1027 0.6805 0.7122
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0113 0.0634 0.2074
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0014 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0111 0.0109
Schistosoma mansoni lozenge 0.0062 0.0289 0.0296
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0007 0.0001
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0103 0.0572 0.084
Trichomonas vaginalis cyclin-dependent kinases regulatory subunit, putative 0.0033 0.0096 0.0082
Onchocerca volvulus 0.0029 0.0072 0.0071
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0096 0.0141
Echinococcus multilocularis carbonic anhydrase 0.0468 0.3031 0.4454
Brugia malayi jmjC domain containing protein 0.002 0.0007 0.0001
Echinococcus granulosus smad 0.0025 0.0042 0.0062
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0072 0.0071
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0063 0.0295 0.0434
Brugia malayi solute carrier family 40, member 1 0.1395 0.9285 1
Schistosoma mansoni protein phosphatase 2C 0.002 0.0007 0.0001
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0091 0.0123
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0007 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.067 0.0985
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0098 0.0099
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0042 0.0062
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0068 0.0329 0.0316
Loa Loa (eye worm) hypothetical protein 0.0151 0.0895 0.0964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1204 0.7995 0.7992
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0072 0.0106
Echinococcus multilocularis transcription factor Dp 1 0.0236 0.1468 0.2158
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0103 0.0572 0.0558
Schistosoma mansoni steroid hormone receptor ad4bp 0.0063 0.0295 0.0302
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0588 0.3841 0.2951
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0408 0.2629 0.2826
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1204 0.7995 0.8368
Leishmania major cyclin-dependent kinase regulatory subunit 0.0033 0.0096 0.0092
Loa Loa (eye worm) carbonic anhydrase 3 0.1027 0.6805 0.7329
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0063 0.0295 0.0318
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0098 0.0144
Brugia malayi Muscleblind-like protein 0.015 0.0883 0.0944
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0014 0.001
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0295 0.0302
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0009 0.0006
Echinococcus granulosus GPCR family 2 0.0033 0.0098 0.0144
Echinococcus multilocularis carbonic anhydrase 0.0468 0.3031 0.4454
Trypanosoma brucei transcription factor BTF3, putative 0.0039 0.0135 0.0188
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.308 0.4527
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0072 0.0106
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.067 0.0985
Loa Loa (eye worm) hypothetical protein 0.0033 0.0096 0.0104
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0072 0.0078
Toxoplasma gondii NAC domain-containing protein 0.0039 0.0135 0.0423
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0009 0.0006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078
Onchocerca volvulus Protein ultraspiracle homolog 0.0063 0.0295 0.0311
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0072 0.0106
Trypanosoma brucei carbonic anhydrase-like protein 0.1027 0.6805 1
Toxoplasma gondii exonuclease III APE 0.0021 0.0014 0.0022
Echinococcus granulosus transcription factor eb 0.0108 0.0603 0.0886
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0408 0.2629 0.2747
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0063 0.0295 0.0302
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0468 0.3031 0.326
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0056 0.006
Echinococcus multilocularis ecdysone induced protein 78C 0.0063 0.0295 0.0434
Wolbachia endosymbiont of Brugia malayi DNA polymerase III alpha subunit 0.0257 0.1607 1
Schistosoma mansoni hypothetical protein 0.0072 0.0359 0.0369
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0007 0.0001
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.308 0.4527
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0072 0.0069
Echinococcus granulosus jumonji domain containing protein 0.0086 0.0451 0.0663
Brugia malayi nuclear receptor NHR-88 0.0063 0.0295 0.0311
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0359 0.038
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0408 0.2629 0.2742
Leishmania major hypothetical protein, conserved 0.003 0.0077 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0295 0.0311
Schistosoma mansoni jumonji/arid domain-containing protein 0.0078 0.0399 0.0412
Schistosoma mansoni phd/f-box containing protein 0.002 0.0007 0.0001
Brugia malayi jmjC domain containing protein 0.0078 0.0399 0.0423
Onchocerca volvulus 0.003 0.0077 0.0076
Echinococcus multilocularis GPCR, family 2 0.0033 0.0098 0.0144
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0113 0.0634 0.0776
Plasmodium falciparum phd finger protein, putative 0.0062 0.0289 0.0933
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1027 0.6805 1
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0096 0.0097
Mycobacterium ulcerans integral membrane transporter 0.0032 0.0091 0.0077
Echinococcus granulosus muscleblind protein 0.015 0.0883 0.1297
Onchocerca volvulus 0.0202 0.1239 0.1328
Brugia malayi hypothetical protein 0.0219 0.1354 0.1452
Echinococcus granulosus tissue type plasminogen activator 0.003 0.0077 0.0114
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0468 0.3031 0.3265
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.0083
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0072 0.0106
Schistosoma mansoni RAR-like nuclear receptor 0.0063 0.0295 0.0302
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0113 0.0634 0.2072
Schistosoma mansoni coup transcription factor 0.0063 0.0295 0.0302
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0032 0.0091 0.0077
Brugia malayi hypothetical protein 0.0151 0.0895 0.0957
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0036 0.0116 0.0159
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0584 0.0622
Brugia malayi glucose-6-phosphate dehydrogenase 0.0103 0.0572 0.0609
Trichomonas vaginalis cyclin-dependent kinases regulatory subunit, putative 0.0033 0.0096 0.0082
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0014 0.0121
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0072 0.0069
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0072 0.0106
Schistosoma mansoni hypothetical protein 0.0062 0.0289 0.0296
Loa Loa (eye worm) hypothetical protein 0.0492 0.319 0.3436
Echinococcus granulosus FTZ F1 alpha 0.0063 0.0295 0.0434
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.0295 0.0302
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0108 0.0603 0.0643
Echinococcus multilocularis cyclin dependent kinases regulatory subunit 0.0033 0.0096 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0053
Loa Loa (eye worm) hypothetical protein 0.0062 0.0289 0.0311
Loa Loa (eye worm) DR-78 0.0029 0.0072 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.1501 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0078 0.0399 0.043
Brugia malayi nuclear hormone receptor 0.0029 0.0072 0.0071
Schistosoma mansoni intermediate filament proteins 0.0027 0.0056 0.0051
Echinococcus multilocularis FTZ F1 alpha 0.0063 0.0295 0.0434
Loa Loa (eye worm) hypothetical protein 0.002 0.0007 0.0008
Loa Loa (eye worm) doublecortin family protein 0.002 0.0007 0.0007
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0072 0.0106
Onchocerca volvulus 0.0027 0.0056 0.0053
Echinococcus granulosus transcription factor btf3 0.0039 0.0135 0.0199
Giardia lamblia Cyclin-dependent kinases regulatory subunit 0.0033 0.0096 0.0102
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.015 0.0883 0.0951
Echinococcus multilocularis RUN 0.002 0.0007 0.001
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0289 0.4497
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0219 0.1354 0.1989
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0063 0.0295 0.0434
Trypanosoma cruzi transcription factor btf3, putative 0.0039 0.0135 0.0188
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0014 0.001
Echinococcus granulosus Smad4 0.0025 0.0042 0.0062
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0031 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0014 0.0015
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0897 0.5927 0.9295
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0096 0.0104
Echinococcus multilocularis musashi 0.0027 0.0056 0.0082
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0044 0.0053
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.0451 0.0663
Schistosoma mansoni hypothetical protein 0.0033 0.0098 0.0096
Schistosoma mansoni cpg binding protein 0.0061 0.0283 0.0289
Echinococcus granulosus lamin 0.0027 0.0056 0.0082
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0007 0.001
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0103 0.0572 0.0591
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0135 0.0121
Schistosoma mansoni cpg binding protein 0.0064 0.0306 0.0313
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0044 0.0123
Brugia malayi hypothetical protein 0.0085 0.0448 0.0476
Chlamydia trachomatis DNA polymerase III subunit alpha 0.0257 0.1607 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0295 0.0318
Schistosoma mansoni lipoxygenase 0.0083 0.0431 0.0444
Brugia malayi ecdysone receptor 0.0029 0.0072 0.0071
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0771 0.5074 0.7954
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0098 0.0144
Schistosoma mansoni retinoic acid receptor RXR 0.0063 0.0295 0.0302
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0042 0.0062
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0096 0.0094
Toxoplasma gondii kringle domain-containing protein 0.003 0.0077 0.0231
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0009 0.0002
Plasmodium falciparum carbonic anhydrase 0.0468 0.3031 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0007 0.001
Echinococcus granulosus lamin dm0 0.0027 0.0056 0.0082
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0078

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.077 uM Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]-dTMP 250 pM (30 degree C for 10 min) ChEMBL. 16250666
Ki (binding) = 0.077 uM Inhibitory concentration against Bacillus subtilis DNA polymerase IIIC using [3H]-dTMP 250 pM (30 degree C for 10 min) ChEMBL. 16250666
MIC (functional) = 2.5 ug ml-1 In vitro minimum inhibitory concentration against Bacillus subtilis upon incubation at 37 degree C for 16 to 24 h ChEMBL. 16250666
MIC (functional) = 5 ug ml-1 In vitro minimum inhibitory concentration against Enterococcus fecium upon incubation at 37 degree C for 16 to 24 h by dissolving in DMSO (1%) ChEMBL. 16250666
MIC (functional) = 5 ug ml-1 In vitro minimum inhibitory concentration against Vancomycin resistant Enterococci faecium upon incubation at 37 degree C for 16 to 24 h by dissolving in DMSO (1%) ChEMBL. 16250666
MIC (functional) = 10 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus upon incubation at 37 degree C for 16 to 24 h by dissolving in DMSO (1%) ChEMBL. 16250666
MIC (functional) = 10 ug ml-1 In vitro minimum inhibitory concentration against Staphylococcus aureus (Smith) upon incubation at 37 degree C for 16 to 24 h by dissolving in DMSO (1%) ChEMBL. 16250666
MIC (functional) = 10 ug ml-1 In vitro minimum inhibitory concentration against Methicillin-resistant Staphylococcus aureus upon incubation at 37 degree C for 16 to 24 h by dissolving in DMSO (1%) ChEMBL. 16250666
MIC (functional) = 10 ug ml-1 In vitro minimum inhibitory concentration against Enterococcus faecalis upon incubation at 37 degree C for 16 to 24 h by dissolving in DMSO (1%) ChEMBL. 16250666

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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