TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.583 | Formula: C22H34N2OS
H donors: 1 H acceptors: 1 LogP: 4.54 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCC1CNC(=O)C21CCN(CC2)C1(CCCCC1)c1ccc(s1)C
InChi: 1S/C22H34N2OS/c1-3-7-18-16-23-20(25)21(18)12-14-24(15-13-21)22(10-5-4-6-11-22)19-9-8-17(2)26-19/h8-9,18H,3-7,10-16H2,1-2H3,(H,23,25)
InChiKey: IBBBSENXABSARG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus multilocularis	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus granulosus	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	Sodium- and chloride-dependent glycine transporter 1, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	Sodium- and chloride-dependent glycine transporter 1, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus granulosus	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Echinococcus multilocularis	sodium and chloride dependent glycine	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma japonicum	Sodium-dependent proline transporter, putative	Get druggable targets OG5_128673	All targets in OG5_128673
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128673	All targets in OG5_128673
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128673	All targets in OG5_128673

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	serotonin transporter	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	633 aa	616 aa	38.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	histone deacetylase, putative	0.0236	0.8157	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0024	0.0442	0.0387
Echinococcus multilocularis	neuroglian	0.0022	0.0401	0.0432
Schistosoma mansoni	septate junction protein	0.0013	0.0042	0.0049
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0022	0.0401	0.0432
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0259	0.0311
Plasmodium vivax	histone deacetylase 2, putative	0.0213	0.7303	0.7267
Schistosoma mansoni	nephrin related	0.0013	0.0042	0.0049
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0024	0.0442	0.0527
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0225
Trichomonas vaginalis	histone deacetylase, putative	0.0236	0.8157	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Echinococcus granulosus	basement membrane specific heparan sulfate	0.0013	0.0042	0.0044
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0267
Schistosoma mansoni	peroxidasin	0.0013	0.0042	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0988	0.1166
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0024	0.0442	0.0542
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0259	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.032	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0077	0.0043
Plasmodium falciparum	transporter, putative	0.0019	0.0259	0.0128
Schistosoma mansoni	amine GPCR	0.024	0.8298	1
Echinococcus multilocularis	roundabout 2	0.0022	0.0401	0.0432
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0096	0.305	0.3707
Toxoplasma gondii	histone deacetylase HDAC5	0.0102	0.3269	0.3951
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0019	0.0259	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0379	0.0416
Echinococcus granulosus	histone deacetylase 6	0.0213	0.7303	0.7901
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Loa Loa (eye worm)	heterochromatin protein 1	0.0039	0.1003	0.1184
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0021	0.0336	0.0207
Trypanosoma brucei	glucose transporter 2A	0.0021	0.0345	0.0408
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0013	0.0073	0.0011
Treponema pallidum	sodium- and chloride- dependent transporter	0.0019	0.0259	0.5
Schistosoma mansoni	glucose transport protein	0.0068	0.2038	0.2455
Loa Loa (eye worm)	hypothetical protein	0.0102	0.3269	0.3977
Echinococcus granulosus	histone deacetylase 3	0.0236	0.8157	0.8825
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0021	0.0336	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0096	0.305	0.3707
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0025	0.0491	0.0448
Echinococcus multilocularis	histone deacetylase 8	0.0102	0.3269	0.3536
Schistosoma mansoni	egf-like domain protein	0.0014	0.0077	0.0091
Echinococcus granulosus	roundabout 2	0.0022	0.0401	0.0432
Leishmania major	histone deacetylase, putative	0.0236	0.8157	1
Echinococcus multilocularis	neuroglian	0.0049	0.1347	0.1457
Loa Loa (eye worm)	histone deacetylase	0.0213	0.7303	0.8948
Trichomonas vaginalis	glucose transporter, putative	0.0021	0.0345	0.0347
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0021	0.0336	0.0207
Plasmodium falciparum	histone deacetylase, putative	0.0213	0.7303	0.7267
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0014	0.0077	0.0043
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.002	0.032	0.0316
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0019	0.0259	0.0267
Loa Loa (eye worm)	sugar transporter	0.0068	0.2038	0.246
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0025	0.0491	0.0587
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.002	0.0306	0.0218
Schistosoma mansoni	sodium/chloride dependent transporter	0.0097	0.3097	0.3732
Plasmodium vivax	hexose transporter	0.0068	0.2038	0.1932
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0019	0.0259	0.0311
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0021	0.0335	0.0362
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0019	0.0259	0.0279
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0025	0.0491	0.0602
Echinococcus multilocularis	lysyl tRNA synthetase	0.0015	0.0132	0.0142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.0173	0.0134
Echinococcus multilocularis	roundabout 2	0.0061	0.1805	0.1952
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0013	0.007	0.0035
Echinococcus granulosus	laminin	0.0014	0.0077	0.0082
Brugia malayi	Fibronectin type III domain containing protein	0.0039	0.0988	0.1166
Echinococcus granulosus	roundabout 2	0.0061	0.1805	0.1952
Loa Loa (eye worm)	norepinephrine transporter	0.0019	0.0259	0.0267
Schistosoma mansoni	chromobox protein	0.0039	0.1003	0.1208
Trichomonas vaginalis	histone deacetylase, putative	0.0236	0.8157	1
Toxoplasma gondii	hypothetical protein	0.0019	0.0259	0.0225
Echinococcus granulosus	lachesin	0.0022	0.0401	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0111	0.3618	0.4407
Plasmodium falciparum	histone deacetylase 1	0.0236	0.8157	0.8132
Schistosoma mansoni	protein kinase	0.0021	0.0335	0.0403
Echinococcus multilocularis	chromobox protein 1	0.0039	0.1003	0.1084
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Schistosoma mansoni	netrin receptor unc5	0.0013	0.0042	0.0049
Trypanosoma cruzi	histone deacetylase 1, putative	0.0236	0.8157	1
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0025	0.0491	0.0531
Echinococcus granulosus	Tolloid protein 1	0.0014	0.0077	0.0082
Echinococcus multilocularis	netrin receptor unc 5	0.0013	0.0042	0.0044
Schistosoma mansoni	histone deacetylase hda2	0.0219	0.7524	0.9068
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0401	0.0482
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0015	0.0132	0.0162
Loa Loa (eye worm)	phosphatidylinositol 3	0.0025	0.0491	0.0554
Echinococcus granulosus	neuropeptide receptor A26	0.0266	0.9243	1
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Loa Loa (eye worm)	TK/ROR protein kinase	0.0013	0.007	0.0035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0306	0.0298
Leishmania major	glucose transporter, lmgt2	0.0021	0.0345	0.0266
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0514	0.0387
Echinococcus granulosus	Immunoglobulin	0.0013	0.0042	0.0044
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.002	0.0306	0.036
Loa Loa (eye worm)	histone deacetylase 11	0.0102	0.3269	0.3977
Echinococcus multilocularis	histone deacetylase 6	0.0219	0.7524	0.814
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0021	0.0359	0.0364
Leishmania major	histone deacetylase, putative	0.0236	0.8157	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0988	0.1166
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.002	0.032	0.0385
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0022	0.0401	0.0432
Brugia malayi	Calcium binding EGF domain containing protein	0.0014	0.0077	0.0043
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0013	0.0042	0.0049
Onchocerca volvulus		0.0019	0.0259	0.0589
Echinococcus granulosus	General substrate transporter	0.0058	0.1693	0.1831
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Trichomonas vaginalis	histone deacetylase, putative	0.0236	0.8157	1
Echinococcus granulosus	Immunoglobulin	0.0013	0.0042	0.0044
Trichomonas vaginalis	CAMK family protein kinase	0.0021	0.0335	0.0335
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0013	0.0042	0.0049
Schistosoma mansoni	cell adhesion molecule	0.0051	0.1446	0.1742
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0379	0.0389
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0096	0.305	0.3299
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0019	0.0259	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0021	0.0345	0.0347
Brugia malayi	Sugar transporter family protein	0.0068	0.2038	0.246
Loa Loa (eye worm)	hypothetical protein	0.0117	0.3839	0.468
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0335	0.0362
Brugia malayi	chromobox protein homolog 3	0.0022	0.0379	0.0416
Trypanosoma brucei	histone deacetylase 3	0.0213	0.7303	0.8952
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0491	0.0528
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0022	0.0401	0.0432
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0236	0.8157	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0021	0.0336	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0077	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1805	0.2173
Schistosoma mansoni	basigin related	0.0013	0.0042	0.0049
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0021	0.0345	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1805	0.2173
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0013	0.0042	0.0044
Trypanosoma cruzi	hexose transporter	0.0021	0.0345	0.0423
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0514	0.0387
Schistosoma mansoni	cell adhesion molecule	0.0013	0.0042	0.0049
Schistosoma mansoni	septate junction protein	0.0022	0.0401	0.0482
Echinococcus granulosus	histone deacetylase 6	0.0213	0.7303	0.7901
Plasmodium vivax	histone deacetylase, putative	0.0213	0.7303	0.7267
Echinococcus multilocularis	hemicentin 1	0.0022	0.0401	0.0432
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0014	0.0077	0.0043
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0514	0.0387
Trypanosoma cruzi	hexose transporter, putative	0.0021	0.0345	0.0423
Schistosoma mansoni	hypothetical protein	0.0013	0.0042	0.0049
Plasmodium vivax	amine transporter, putative	0.0019	0.0259	0.0128
Brugia malayi	Histone deacetylase 1	0.0236	0.8157	1
Trypanosoma brucei	histone deacetylase, putative	0.0213	0.7303	0.8952
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0014	0.0077	0.0043
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0028	0.0599	0.0687
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0039	0.0988	0.1166
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Schistosoma mansoni	septate junction protein	0.0022	0.0401	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Brugia malayi	histone deacetylase 11	0.0102	0.3269	0.3977
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0514	0.063
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0013	0.0073	0.0011
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0021	0.0336	0.0321
Plasmodium falciparum	hexose transporter	0.0068	0.2038	0.1932
Schistosoma mansoni	lysyl-tRNA synthetase	0.0015	0.0132	0.0158
Toxoplasma gondii	hypothetical protein	0.0019	0.0259	0.0225
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0013	0.007	0.0075
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0335	0.0403
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0147	0.0102
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0021	0.0335	0.0396
Schistosoma mansoni	nephrin	0.0022	0.0401	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0019	0.0259	0.0226
Echinococcus multilocularis	Immunoglobulin	0.0013	0.0042	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Plasmodium vivax	proline--tRNA ligase, putative	0.0024	0.0442	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2971	0.361
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Trypanosoma cruzi	histone deacetylase, putative	0.0213	0.7303	0.8954
Leishmania major	glucose transporter, lmgt3	0.0021	0.0345	0.0266
Echinococcus multilocularis	chromobox protein 1	0.0039	0.1003	0.1084
Brugia malayi	Peroxidasin	0.0022	0.0401	0.0442
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0028	0.0599	0.0687
Brugia malayi	hypothetical protein	0.0039	0.0988	0.1166
Echinococcus granulosus	pro neuregulin 2 membrane bound	0.0013	0.0042	0.0044
Schistosoma mansoni	histone deacetylase hda2	0.0102	0.3269	0.3939
Loa Loa (eye worm)	histone deacetylase 3	0.0236	0.8157	1
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Echinococcus multilocularis	pro neuregulin 2, membrane bound	0.0013	0.0042	0.0044
Echinococcus granulosus	3'partial\|cell adhesion molecule:down regulated by	0.0013	0.0042	0.0044
Trichomonas vaginalis	chromobox protein, putative	0.0024	0.044	0.0464
Echinococcus granulosus	netrin receptor unc 5	0.0013	0.0042	0.0044
Trypanosoma cruzi	hexose transporter, putative	0.0021	0.0345	0.0423
Echinococcus granulosus	neuroglian	0.0049	0.1347	0.1457
Trypanosoma cruzi	histone deacetylase, putative	0.0213	0.7303	0.8954
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Echinococcus multilocularis	low density lipoprotein receptor (ldl)	0.0013	0.0042	0.0044
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Plasmodium falciparum	proline--tRNA ligase	0.0024	0.0442	0.0315
Trichomonas vaginalis	histone deacetylase, putative	0.0236	0.8157	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0266	0.9243	1
Echinococcus multilocularis	histone deacetylase 6	0.0213	0.7303	0.7901
Schistosoma mansoni	histone deacetylase 4 5	0.0213	0.7303	0.8802
Toxoplasma gondii	histone deacetylase HDAC1	0.0213	0.7303	0.8944
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0074	0.0012
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0401	0.0482
Giardia lamblia	Prolyl-tRNA synthetase	0.002	0.032	0.0235
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Trichomonas vaginalis	histone deacetylase, putative	0.0236	0.8157	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0025	0.0491	0.0591
Trypanosoma brucei	histone deacetylase 2	0.0102	0.3269	0.3998
Schistosoma mansoni	septate junction protein	0.0013	0.0042	0.0049
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0022	0.0401	0.0432
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0013	0.0042	0.0049
Echinococcus multilocularis	Immunoglobulin	0.0039	0.0988	0.1068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0022	0.0401	0.0432
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0109	0.355	0.4298
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0132	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0015	0.0132	0.5
Echinococcus multilocularis	Immunoglobulin	0.0039	0.0988	0.1068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0193	0.0159
Echinococcus granulosus	low density lipoprotein receptor ldl	0.0013	0.0042	0.0044
Echinococcus multilocularis	Immunoglobulin	0.0013	0.0042	0.0044
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0013	0.0042	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1481	0.1773
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Toxoplasma gondii	protein kinase, putative	0.0191	0.6518	0.7971
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0025	0.0491	0.0448
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0025	0.0491	0.0602
Onchocerca volvulus		0.0017	0.0207	0.0429
Echinococcus granulosus	hemicentin 1	0.0022	0.0401	0.0432
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0021	0.0336	0.0207
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0021	0.0336	0.0207
Loa Loa (eye worm)	histone deacetylase 7A	0.0213	0.7303	0.8948
Brugia malayi	Heterochromatin protein 1	0.0039	0.1003	0.1184
Schistosoma mansoni	glucose transport protein	0.0068	0.2038	0.2455
Brugia malayi	histone deacetylase 1 (HD1)	0.0236	0.8157	1
Brugia malayi	Histone deacetylase family protein	0.0213	0.7303	0.8948
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.002	0.032	0.0385
Echinococcus multilocularis	leucine rich repeat containing protein 4	0.0013	0.0042	0.0044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0306	0.0298
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0013	0.0042	0.0049
Echinococcus multilocularis	peroxidasin	0.0022	0.0401	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0074	0.0012
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Plasmodium falciparum	histone deacetylase 2	0.0213	0.7303	0.7267
Giardia lamblia	Histone deacetylase	0.0236	0.8157	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0121	0.007
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0021	0.0335	0.0362
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0225
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0096	0.305	0.3299
Echinococcus multilocularis	serotonin receptor	0.0093	0.2971	0.3214
Plasmodium falciparum	protein kinase 7	0.0191	0.6518	0.6471
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Loa Loa (eye worm)	histone deacetylase 1	0.0236	0.8157	1
Toxoplasma gondii	histone deacetylase HDAC4	0.0102	0.3269	0.3951
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.002	0.032	0.0235
Echinococcus multilocularis	histone deacetylase 1	0.0236	0.8157	0.8825
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0126	0.0077
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.1003	0.116
Plasmodium falciparum	amino acid transporter, putative	0.0019	0.0259	0.0128
Echinococcus granulosus	peroxidasin	0.0022	0.0401	0.0432
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0019	0.0259	0.0311
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0514	0.0614
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0287	1	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0013	0.0049	0.5
Schistosoma mansoni	protein kinase	0.0021	0.0335	0.0403
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0019	0.0259	0.0279
Echinococcus multilocularis	lachesin	0.0022	0.0401	0.0432
Trypanosoma cruzi	histone deacetylase 1, putative	0.0236	0.8157	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0024	0.044	0.1155
Echinococcus granulosus	histone deacetylase 1	0.0236	0.8157	0.8825
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0019	0.0259	0.0279
Echinococcus granulosus	roundabout 2	0.0022	0.0401	0.0432
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0074	0.0012
Schistosoma mansoni	roundabout	0.0022	0.0401	0.0482
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0022	0.0401	0.1032
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.002	0.032	0.0346
Echinococcus multilocularis	Tolloid protein 1	0.0014	0.0077	0.0082
Echinococcus multilocularis	General substrate transporter	0.0058	0.1693	0.1831
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0039	0.0988	0.1068
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0126	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0022	0.0401	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0014	0.0077	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0988	0.1166
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0121	0.007
Trichomonas vaginalis	sugar transporter, putative	0.0021	0.0345	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0306	0.0298
Trypanosoma cruzi	histone deacetylase, putative	0.0102	0.3269	0.4008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0013	0.0073	0.0011
Echinococcus granulosus	contactin	0.0022	0.0401	0.0432
Leishmania major	hypothetical protein, conserved	0.0026	0.0514	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0236	0.8157	1
Trypanosoma brucei	glucose transporter 1E	0.0021	0.0345	0.0408
Loa Loa (eye worm)	hypothetical protein	0.0096	0.305	0.3707
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0022	0.0401	0.0442
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0514	0.063
Entamoeba histolytica	protein kinase, putative	0.0021	0.0335	0.0254
Schistosoma mansoni	histone deacetylase 1 2 3	0.0102	0.3269	0.3939
Echinococcus multilocularis	roundabout 2	0.0022	0.0401	0.0432
Onchocerca volvulus		0.0019	0.0259	0.0589
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0028	0.0599	0.0687
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0025	0.0491	0.0448
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0021	0.0336	0.0207
Brugia malayi	hypothetical protein	0.0017	0.0184	0.0175
Echinococcus granulosus	calcium dependent protein kinase	0.0019	0.0289	0.0312
Brugia malayi	lysyl-tRNA synthetase	0.0015	0.0132	0.0111
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0019	0.0259	0.0279
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0025	0.0491	0.0531
Echinococcus granulosus	chromobox protein 1	0.0039	0.1003	0.1084
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0491	0.0528
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0514	0.0581
Echinococcus multilocularis	histone deacetylase 6	0.0213	0.7303	0.7901
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0039	0.0988	0.119
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0015	0.0132	0.0083
Leishmania major	glucose transporter, lmgt1	0.0021	0.0345	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0014	0.0077	0.0043
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Brugia malayi	hypothetical protein	0.0026	0.0514	0.0581
Leishmania major	histone deacetylase, putative	0.0213	0.7303	0.8937
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0055	0.1574	0.1888
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0024	0.0447	0.05
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0259	0.0311
Onchocerca volvulus		0.0019	0.0259	0.0589
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0267
Schistosoma mansoni	hypothetical protein	0.0013	0.0042	0.0049
Trichomonas vaginalis	chromobox protein, putative	0.0024	0.044	0.0464
Echinococcus multilocularis	calcium dependent protein kinase	0.0019	0.0289	0.0312
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0021	0.0336	0.0207
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0019	0.0259	0.0311
Echinococcus granulosus	neuropeptide s receptor	0.0266	0.9243	1
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Schistosoma mansoni	sodium/chloride dependent transporter	0.0096	0.305	0.3675
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0025	0.0491	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0988	0.1166
Trypanosoma brucei	histone deacetylase 1	0.0236	0.8157	1
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0015	0.0132	0.3046
Schistosoma mansoni	chromobox protein	0.0039	0.1003	0.1208
Schistosoma mansoni	hypothetical protein	0.0013	0.0042	0.0049
Echinococcus multilocularis	cell adhesion molecule:down regulated by	0.0013	0.0042	0.0044
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.002	0.032	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0306	0.0298
Echinococcus granulosus	histone deacetylase 8	0.0102	0.3269	0.3536
Schistosoma mansoni	hypothetical protein	0.0013	0.0042	0.0049
Brugia malayi	hypothetical protein	0.0019	0.0259	0.0267
Brugia malayi	Fibulin-1 precursor	0.0014	0.0077	0.0043
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0109	0.355	0.3464
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.002	0.032	0.0343
Schistosoma mansoni	nephrin	0.0049	0.1347	0.1623
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0022	0.0401	0.0482
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0109	0.355	0.3464
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0019	0.0259	0.0267
Schistosoma mansoni	low-density lipoprotein receptor (ldl)	0.0013	0.0042	0.0049
Schistosoma mansoni	tyrosine kinase	0.0026	0.0528	0.0635
Echinococcus multilocularis	neuropeptide s receptor	0.0266	0.9243	1
Echinococcus granulosus	histone deacetylase 7	0.0213	0.7303	0.7901
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0022	0.0401	0.0442
Schistosoma mansoni	sodium/chloride dependent transporter	0.0019	0.0259	0.0311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.002	0.0306	0.0298
Echinococcus granulosus	Immunoglobulin subtype	0.0013	0.0042	0.0044
Brugia malayi	Cam kinase protein 1	0.0021	0.0335	0.0362
Trichomonas vaginalis	sugar transporter, putative	0.0021	0.0345	0.0347
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0015	0.0132	0.0146
Trypanosoma cruzi	histone deacetylase, putative	0.0102	0.3269	0.4008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0207	0.0204
Schistosoma mansoni	hypothetical protein	0.0068	0.2038	0.2455
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0013	0.0042	0.0044
Echinococcus granulosus	histone deacetylase	0.0213	0.7303	0.7901
Trichomonas vaginalis	histone deacetylase, putative	0.0236	0.8157	1
Echinococcus multilocularis	serotonin transporter	0.0019	0.0259	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0599	0.0687
Schistosoma mansoni	lysyl-tRNA synthetase	0.0015	0.0132	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0988	0.1166
Plasmodium vivax	hypothetical protein, conserved	0.0019	0.0259	0.0128
Schistosoma mansoni	neuroglian	0.0022	0.0401	0.0482
Echinococcus multilocularis	histone deacetylase 3	0.0236	0.8157	0.8825
Leishmania major	histone deacetylase, putative	0.0213	0.7303	0.8937
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0024	0.0442	0.0387
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0024	0.0442	0.0542
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0013	0.0049	0.5
Entamoeba histolytica	protein kinase, putative	0.0021	0.0335	0.0254
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0019	0.0259	1
Toxoplasma gondii	lysine-tRNA ligase	0.0015	0.0132	0.0068
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0013	0.007	0.0075
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0022	0.0379	0.0966
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0267
Echinococcus granulosus	tyrosine protein kinase otk	0.0022	0.0401	0.0432
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0345	0.0347
Schistosoma mansoni	titin	0.0022	0.0401	0.0482
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0055	0.1574	0.1888
Schistosoma mansoni	netrin receptor unc5	0.0013	0.0042	0.0049
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Schistosoma mansoni	hypothetical protein	0.0013	0.0042	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0077	0.0043
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0019	0.0259	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Trypanosoma brucei	glucose transporter, putative	0.0021	0.0345	0.0408
Trichomonas vaginalis	glucose transporter, putative	0.0021	0.0345	0.0347
Brugia malayi	Histone deacetylase family protein	0.0213	0.7303	0.8948
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0491	0.0528
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0021	0.0336	0.0207
Schistosoma mansoni	histone deacetylase 4 5	0.0213	0.7303	0.8802
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0022	0.0401	0.0442
Echinococcus multilocularis	laminin	0.0014	0.0077	0.0082
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0051	0.1446	0.1564
Echinococcus granulosus	defective proboscis extension response	0.0039	0.0988	0.1068
Echinococcus granulosus	sodium and chloride dependent glycine	0.0096	0.305	0.3299
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Echinococcus granulosus	Immunoglobulin	0.0039	0.0988	0.1068
Trichomonas vaginalis	conserved hypothetical protein	0.0068	0.2038	0.2439
Schistosoma mansoni	basigin related	0.0013	0.0042	0.0049
Echinococcus granulosus	twitchin	0.005	0.1394	0.1507
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0093	0.2971	0.358
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Trypanosoma cruzi	hexose transporter, putative	0.0021	0.0345	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.0126	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1446	0.1731
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0147	0.0102
Loa Loa (eye worm)	TK protein kinase	0.0013	0.007	0.0035
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Schistosoma mansoni	hypothetical protein	0.0013	0.0042	0.0049
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0015	0.0132	0.5
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0019	0.0259	0.0311
Leishmania major	protein kinase, putative	0.0021	0.0335	0.0254
Echinococcus multilocularis	histone deacetylase 7	0.0213	0.7303	0.7901
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0401	0.0442
Schistosoma mansoni	cell adhesion molecule	0.0013	0.0042	0.0049
Plasmodium vivax	histone deacetylase, putative	0.0102	0.3269	0.3179
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0021	0.0345	0.0408
Echinococcus multilocularis	serotonin receptor	0.0093	0.2971	0.3214
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0025	0.0491	0.0448
Echinococcus multilocularis	fibrillin 1	0.0014	0.0077	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Echinococcus multilocularis	tyrosine protein kinase otk	0.0022	0.0401	0.0432
Echinococcus granulosus	chromobox protein 1	0.0039	0.1003	0.1084
Schistosoma mansoni	vesicular amine transporter	0.0039	0.0988	0.119
Echinococcus multilocularis	Immunoglobulin subtype	0.0013	0.0042	0.0044
Brugia malayi	Prion-like-	0.0022	0.0401	0.0442
Giardia lamblia	GTOR	0.0025	0.0491	0.0448
Echinococcus granulosus	lysyl tRNA synthetase	0.0015	0.0132	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0077	0.0043
Schistosoma mansoni	histone deacetylase	0.0236	0.8157	0.983
Onchocerca volvulus		0.0019	0.0259	0.0589
Echinococcus multilocularis	hemicentin 1	0.0022	0.0401	0.0432
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0021	0.0336	0.0321
Schistosoma mansoni	hypothetical protein	0.0019	0.0278	0.0334
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0022	0.0401	0.0482
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.002	0.032	0.0343
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0236	0.8157	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0024	0.0442	0.0453
Onchocerca volvulus	Arrow homolog	0.0014	0.0077	0.002
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0182	0.0173
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0021	0.0345	0.0408
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.002	0.032	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0021	0.0335	0.0362
Echinococcus granulosus	histone deacetylase 6	0.0219	0.7524	0.814
Trypanosoma brucei	histone deacetylase 4	0.0213	0.7303	0.8952
Plasmodium vivax	histone deacetylase 1, putative	0.0236	0.8157	0.8132
Schistosoma mansoni	histone deacetylase	0.0236	0.8157	0.983
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0021	0.0335	0.0362
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0074	0.0012
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0021	0.0336	0.0321
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.1003	0.116
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0379	0.0389
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0068	0.2038	0.2204
Echinococcus multilocularis	histone deacetylase	0.0213	0.7303	0.7901
Brugia malayi	histone deacetylase 3 (HD3)	0.0236	0.8157	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0021	0.0345	0.0266
Brugia malayi	latrophilin 2 splice variant baaae	0.0019	0.0278	0.0291
Trypanosoma cruzi	histone deacetylase, putative	0.0213	0.7303	0.8954
Echinococcus granulosus	sodium and chloride dependent glycine	0.0096	0.305	0.3299
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Schistosoma mansoni	cell adhesion molecule	0.0022	0.0401	0.0482
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0259	0.0311
Toxoplasma gondii	histone deacetylase HDAC2	0.0236	0.8157	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0039	0.0988	0.119
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0019	0.0259	0.0311
Toxoplasma gondii	facilitative glucose transporter GT1	0.0068	0.2038	0.2428
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0068	0.2038	0.2204
Loa Loa (eye worm)	serotonin transporter b	0.0019	0.0259	0.0267
Loa Loa (eye worm)	hypothetical protein	0.002	0.032	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0278	0.0291
Toxoplasma gondii	histone deacetylase HDAC3	0.0236	0.8157	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0236	0.8157	1
Trichomonas vaginalis	conserved hypothetical protein	0.0021	0.0345	0.0347
Echinococcus granulosus	biogenic amine 5HT receptor	0.0093	0.2971	0.3214
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0022	0.0401	0.0442
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0019	0.0259	0.0279
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0514	0.0541
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0021	0.0335	0.0362
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0102	0.3269	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.2971	0.361
Schistosoma mansoni	glucose transport protein	0.0068	0.2038	0.2455
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0019	0.0259	0.0267
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0259	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0259	0.0267
Echinococcus granulosus	serotonin transporter	0.0019	0.0259	0.0279
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0096	0.305	0.3707
Schistosoma mansoni	protein kinase	0.0021	0.0335	0.0403
Echinococcus granulosus	neuroglian	0.0022	0.0401	0.0432
Trypanosoma cruzi	target of rapamycin kinase 3	0.002	0.0306	0.0376
Schistosoma mansoni	basigin related	0.0013	0.0042	0.0049
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0491	0.0554

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.113 uM	Inhibition of [3H]glycine uptake at GlyT1	ChEMBL.	16762550
EC50 (binding)	= 0.113 uM	Inhibition of [3H]glycine uptake at GlyT1	ChEMBL.	16762550

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 368231