Detailed information for compound 375320

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.424 | Formula: C19H22N7O+
  • H donors: 1 H acceptors: 3 LogP: 1.03 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc(c1)Cn1c(nc2c1c(=O)n(nc2)C)N1CCCC(C1)[NH3+]
  • InChi: 1S/C19H21N7O/c1-24-18(27)17-16(10-22-24)23-19(25-7-3-6-15(21)12-25)26(17)11-14-5-2-4-13(8-14)9-20/h2,4-5,8,10,15H,3,6-7,11-12,21H2,1H3/p+1
  • InChiKey: ZIGLAIZHAHOOFA-UHFFFAOYSA-O  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0634 0.0701
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.6045 0.6898
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0147 0.0455
Schistosoma mansoni hypothetical protein 0.0015 0.038 0.0412
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0022 0.0651 0.101
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.1537 0.1735
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.1934 0.7027
Loa Loa (eye worm) hypothetical protein 0.001 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0147 0.0142
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.1655 0.1655
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.4015 0.4599
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0436 0.0476
Echinococcus granulosus expressed conserved protein 0.0092 0.3694 0.4228
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0436 0.0476
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0151 0.0147
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.1454 0.1639
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0436 0.0473
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.6045 0.6936
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0151 0.0147
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0531 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0151 0.0147
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.1266 0.1432
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0484 0.0742
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1934 0.7027
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0023 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0151 0.0147
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0147 0.0759
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0531 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0147 0.0142
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.1537 0.1745
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0531 0.2151
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0147 0.0143
Loa Loa (eye worm) hypothetical protein 0.0046 0.1706 0.1929
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0456 0.0499
Echinococcus granulosus ornithine aminotransferase 0.0022 0.0651 0.0724
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0531 0.0586
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Brugia malayi ecdysteroid receptor 0.001 0.0151 0.0146
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0151 0.0146
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0151 0.0146
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0531 0.369
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0742 0.1155
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0147 0.0455
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0022 0.0651 0.072
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0151 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0151 0.0146
Mycobacterium ulcerans hypothetical protein 0.0152 0.6247 1
Schistosoma mansoni hypothetical protein 0.0041 0.1472 0.1669
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0022 0.0651 0.101
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.1454 0.1454
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1687 0.1917
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.1537 0.1745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0443 0.0675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0151 0.0146
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1019 0.1147
Brugia malayi Bromodomain containing protein 0.0042 0.152 0.1715
Loa Loa (eye worm) hypothetical protein 0.0054 0.2032 0.2301
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0152 0.6247 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0151 0.0146
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0436 0.0476
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.8705 0.9945
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0531 0.762
Loa Loa (eye worm) hypothetical protein 0.0018 0.0484 0.0529
Loa Loa (eye worm) hypothetical protein 0.0038 0.137 0.1544
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0436 0.1052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1687 0.1917
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1934 0.7027
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0152 0.6247 0.6247
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0151 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0151 0.0146
Brugia malayi prolyl oligopeptidase family protein 0.007 0.2743 0.3116
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.1934 0.2202
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.5763 0.6612
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0456 0.0499
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1454 0.1454
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0691 0.077
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0151 0.0147
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.1454 0.7311
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.1454 0.1648
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0484 0.0742
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0151 0.0147
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0147 0.0147
Onchocerca volvulus 0.001 0.0147 0.0124
Loa Loa (eye worm) hypothetical protein 0.0018 0.0484 0.0529
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0531 0.0582
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0151 0.0147
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0436 0.1052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1751 0.199
Loa Loa (eye worm) hypothetical protein 0.0098 0.395 0.4498
Mycobacterium ulcerans L-lysine aminotransferase 0.0022 0.0651 0.101
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0024 0.0742 0.0823
Echinococcus granulosus zinc finger protein 0.0023 0.0716 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0151 0.0146
Schistosoma mansoni ap endonuclease 0.0019 0.0531 0.0586
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0151 0.0128
Brugia malayi hypothetical protein 0.001 0.0147 0.0142
Schistosoma mansoni ap endonuclease 0.0019 0.0531 0.0586
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.1934 0.2202
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0531 0.3116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0151 0.0147
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.2743 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0691 0.077
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.1934 1
Plasmodium vivax ornithine aminotransferase, putative 0.0022 0.0651 0.3852
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0742 0.183
Toxoplasma gondii hypothetical protein 0.0017 0.0436 0.1518
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1687 0.1917
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0151 0.0146
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0151 0.0147
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0443 0.0675
Echinococcus multilocularis Aminotransferase class III 0.0022 0.0651 0.0724
Echinococcus multilocularis expressed conserved protein 0.0092 0.3694 0.4228
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.2213 0.2522
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.1454 0.1648
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0147 0.0142
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.395 0.4523
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0436 0.1518
Leishmania major oligopeptidase b 0.0017 0.0436 0.1518
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0151 0.0147
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.2213 0.3518
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0151 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0742 0.1155
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0022 0.0651 0.101
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1934 0.1934
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1934 0.1934
Brugia malayi DKFZp564C0469 protein 0.001 0.0147 0.0142
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0022 0.0651 0.101
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.2213 0.8049
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1454 0.5259
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0022 0.0651 0.101
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.1401 0.7014
Mycobacterium ulcerans acetylornithine aminotransferase 0.0022 0.0651 0.101
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0436 0.0476
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0484 0.6692
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.8705 0.8702
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.8705 0.9945
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.395 0.4523
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0018 0.0484 0.0529
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0742 0.0823
Schistosoma mansoni patched 1 0.0042 0.1537 0.1745
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0022 0.0651 0.101
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0147 0.0455
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.5763 0.6612
Echinococcus granulosus replication factor c subunit 1 0.001 0.0147 0.0143
Schistosoma mansoni coup transcription factor 0.001 0.0151 0.0147
Echinococcus multilocularis nibrin 0.001 0.0147 0.0143
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.2213 0.3518
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0151 0.0147
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1934 0.1934
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0436 0.0476
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.395 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.1655 0.5998
Entamoeba histolytica prolyl oligopeptidase family protein 0.0017 0.0436 0.1052
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0651 0.101
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0531 0.0586
Loa Loa (eye worm) hypothetical protein 0.0047 0.1751 0.1979
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0742 0.1155
Schistosoma mansoni hypothetical protein 0.0021 0.0609 0.0676
Brugia malayi PHD-finger family protein 0.0028 0.0945 0.1057
Loa Loa (eye worm) hypothetical protein 0.0071 0.2759 0.3134
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0151 0.0147
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.8705 1
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0147 0.0142
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0531 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0436 0.1518
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0436 0.1052
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0484 0.335
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.5769 0.6619
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0152 0.6247 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.2045 0.2317
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.1934 0.2202
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0147 0.0199
Brugia malayi Bromodomain containing protein 0.0079 0.3095 0.3519
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1687 0.1917
Loa Loa (eye worm) hypothetical protein 0.0024 0.0742 0.0823
Brugia malayi hypothetical protein 0.001 0.0147 0.0142
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0456 0.0499
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0147 0.0147
Brugia malayi nuclear receptor NHR-88 0.001 0.0151 0.0146
Echinococcus granulosus FTZ F1 alpha 0.001 0.0151 0.0147
Trypanosoma cruzi ISWI complex protein 0.0015 0.038 0.1315
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0436 0.0436
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0147 0.0455
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.2743 1
Schistosoma mansoni topbp1 0.001 0.0147 0.0143
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0017 0.0436 0.0664
Loa Loa (eye worm) hypothetical protein 0.0024 0.0742 0.0823
Echinococcus multilocularis protein patched 0.0042 0.1537 0.1745
Plasmodium falciparum ornithine aminotransferase 0.0022 0.0651 0.4562
Mycobacterium tuberculosis Probable aminotransferase 0.0152 0.6247 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0151 0.0146
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.1454 0.1454
Loa Loa (eye worm) hypothetical protein 0.001 0.0147 0.0142
Schistosoma mansoni hypothetical protein 0.0041 0.1472 0.1669
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1687 0.1907
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0151 0.0128
Plasmodium vivax SET domain protein, putative 0.003 0.1019 0.6105
Toxoplasma gondii histone lysine methyltransferase SET1 0.0007 0.0026 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0151 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.1934 0.2202
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.8705 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0436 0.0436
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1934 0.1934
Loa Loa (eye worm) hypothetical protein 0.0052 0.1946 0.2202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1687 0.1917
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0147 0.0455
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0151 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1687 0.1917
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0151 0.0147
Loa Loa (eye worm) hypothetical protein 0.0008 0.006 0.0043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.8753 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0971 0.1093
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0742 0.1155
Plasmodium falciparum peptidase, putative 0.0017 0.0436 0.2998
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.1537 0.1537
Loa Loa (eye worm) hypothetical protein 0.0017 0.0436 0.0473
Brugia malayi nuclear hormone receptor 0.001 0.0151 0.0146
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0022 0.0651 0.101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0742 0.1155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.1751 0.199
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0436 0.1618
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0023 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1687 0.1917
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0147 0.0455
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.1454 0.1648
Schistosoma mansoni DNA ligase IV 0.001 0.0147 0.0143
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1687 0.1907
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.1655 0.5998
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.1019 0.1147
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0147 0.0147
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.2213 0.2522
Brugia malayi hypothetical protein 0.0054 0.2032 0.2301
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0436 0.0473
Schistosoma mansoni topbp1 0.001 0.0147 0.0143
Entamoeba histolytica hypothetical protein 0.001 0.0147 0.0315
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0436 0.1518
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.1454 0.1648
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0436 0.1518
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0151 0.0147
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0436 0.0664
Trypanosoma cruzi oligopeptidase b 0.0017 0.0436 0.1518
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.2743 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.6045 0.6936
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0151 0.0146
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.2743 0.3134
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.1934 0.219
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Loa Loa (eye worm) hypothetical protein 0.0018 0.0484 0.0529
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0531 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0147 0.0147
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.1454 0.1648
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.2213 0.2522
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.1655 0.1879
Echinococcus granulosus Aminotransferase class III 0.0022 0.0651 0.0724
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.1266 0.1432
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0022 0.0651 0.101
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0436 0.0436
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.1934 0.7027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0484 0.0529
Mycobacterium ulcerans hypothetical protein 0.0024 0.0742 0.1155
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.1751 0.199
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0151 0.0147
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.2743 0.3134
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.1019 0.1147
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0147 0.0455
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.1401 0.3508
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.1655 1
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0436 0.0476
Loa Loa (eye worm) hypothetical protein 0.0017 0.0436 0.0473
Trypanosoma cruzi ISWI complex protein 0.0015 0.038 0.1315
Trypanosoma cruzi oligopeptidase b 0.0017 0.0436 0.1518
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0436 0.1618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0151 0.0146
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0443 0.0675
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.1019 0.3662
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.1454 0.5259
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0151 0.0128
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0151 0.0147
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0436 0.1518
Trypanosoma brucei oligopeptidase b 0.0017 0.0436 0.1518
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0651 0.0724
Brugia malayi CHE-14 protein 0.0042 0.1537 0.1735
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0531 0.0531
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0022 0.0651 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0151 0.0147
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.1934 0.7027
Echinococcus multilocularis ornithine aminotransferase 0.0022 0.0651 0.0724
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0436 0.1518
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0484 0.2829
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.2743 0.3134
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0436 0.1518
Schistosoma mansoni zinc finger protein 0.0023 0.0716 0.0799
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0151 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0742 0.0823
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0147 0.0898
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1454 0.5259
Schistosoma mansoni thyroid hormone receptor 0.001 0.0151 0.0147
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0436 0.0664
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0742 0.1155
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0147 0.0147
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0742 0.183
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.2438 0.2782
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.1454 0.1648
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0151 0.0146
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0147 0.0147
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0609 0.0672
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0151 0.0146
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.1934 0.7027
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0531 0.0531
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0742 0.1155
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0436 0.0476
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0151 0.0146
Echinococcus granulosus nibrin 0.001 0.0147 0.0143
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.1934 0.7027
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0151 0.0146
Schistosoma mansoni hypothetical protein 0.0041 0.1472 0.1669
Loa Loa (eye worm) acetyltransferase 0.0147 0.6045 0.6898
Trypanosoma brucei protein kinase, putative 0.0052 0.1934 0.7027
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.1454 0.1648
Loa Loa (eye worm) hypothetical protein 0.004 0.1454 0.1639
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0022 0.0651 0.101
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0147 0.0147
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.395 0.4498
Entamoeba histolytica hypothetical protein, conserved 0.0017 0.0436 0.1052
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0147 0.0315
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0151 0.0146
Echinococcus multilocularis protein dispatched 1 0.0048 0.1794 0.204
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0151 0.0146
Leishmania major hypothetical protein, conserved 0.0015 0.038 0.1315
Loa Loa (eye worm) hypothetical protein 0.0017 0.0436 0.0473
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0436 0.0473
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0022 0.0651 1
Schistosoma mansoni bromodomain containing protein 0.0008 0.006 0.0043
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.2743 1
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0436 0.0473
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.1934 0.2202
Schistosoma mansoni thyroid hormone receptor 0.001 0.0151 0.0147
Trichomonas vaginalis set domain proteins, putative 0.0239 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.1751 0.199
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0151 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0436 0.1518
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0147 0.0199
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.1655 0.1655
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0742 0.1155
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0436 0.1518
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0531 0.1869
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.2213 0.2508
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0443 0.0675
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0151 0.0146
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0436 0.0664
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0017 0.0436 0.1052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0531 0.0817
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0742 0.0823
Loa Loa (eye worm) hypothetical protein 0.001 0.0147 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0151 0.0146
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0436 0.1518
Onchocerca volvulus 0.0011 0.019 0.0168
Schistosoma mansoni hypothetical protein 0.0041 0.1472 0.1669
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0436 0.1518
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0436 0.2531
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0152 0.6247 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0022 0.0651 0.101
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0742 0.2642
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.1454 0.1648
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.1454 0.5259
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.1454 0.3644
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0742 0.183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0151 0.0147
Onchocerca volvulus 0.001 0.0151 0.0128
Onchocerca volvulus 0.0024 0.0742 0.072
Brugia malayi Pre-SET motif family protein 0.003 0.1019 0.1141
Trypanosoma brucei ISWI complex protein 0.0015 0.038 0.1315
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.0436 0.0414
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0151 0.0147
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0022 0.0651 0.0724
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0531 0.1869
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0742 0.1155
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0151 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0742 0.2642
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0436 0.0476
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.2743 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0456 0.0499
Loa Loa (eye worm) hypothetical protein 0.0044 0.1624 0.1835
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.2438 0.2782
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0436 0.1518
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0531 0.1869
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0147 0.0143
Onchocerca volvulus 0.003 0.1019 0.0998
Brugia malayi MAP kinase sur-1 0.0052 0.1934 0.219
Echinococcus granulosus Protein patched homolog 1 0.0042 0.1537 0.1745
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.2213 0.3518
Toxoplasma gondii exonuclease III APE 0.0019 0.0531 0.1869
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0742 0.2642
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0151 0.0146
Brugia malayi Pre-SET motif family protein 0.021 0.8753 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.8705 1
Brugia malayi steroid hormone receptor 0.001 0.0151 0.0146
Brugia malayi topoisomerase 0.001 0.0147 0.0142
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0436 0.1518
Schistosoma mansoni nuclear hormone receptor 0.001 0.0151 0.0147
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.2743 1
Plasmodium vivax SET domain containing protein 0.0007 0.0026 0.0017
Schistosoma mansoni bromodomain containing protein 0.0067 0.2592 0.2959
Echinococcus multilocularis zinc finger protein 0.0023 0.0716 0.0799
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.1401 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0531 0.1869
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.1934 0.7027
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0151 0.0146
Loa Loa (eye worm) hypothetical protein 0.0042 0.1537 0.1735
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0691 0.077
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0147 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0151 0.0146
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0022 0.0651 0.231
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0151 0.0147
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0742 0.1155
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0742 0.1155
Schistosoma mansoni zinc finger protein 0.0015 0.038 0.0412

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 1200 nM Inhibition of h-DPPIV ChEMBL. 17010607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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