Detailed information for compound 375416

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 384.515 | Formula: C22H32N4O2
  • H donors: 2 H acceptors: 3 LogP: 2.07 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C[C@@H]1CCCN1C(=O)CNC(CC(=O)NC(Cc1ccccc1)(C)C)(C)C
  • InChi: 1S/C22H32N4O2/c1-21(2,24-16-20(28)26-12-8-11-18(26)15-23)14-19(27)25-22(3,4)13-17-9-6-5-7-10-17/h5-7,9-10,18,24H,8,11-14,16H2,1-4H3,(H,25,27)/t18-/m0/s1
  • InChiKey: IZOIMXMOBNBUMA-SFHVURJKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Echinococcus multilocularis calpain 7 (C02 family) 0.0042 0.0243 0.0179
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.014 0.1468 0.176
Onchocerca volvulus 0.0071 0.0604 0.0646
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.014 0.1468 0.1781
Brugia malayi Cathepsin L-like precursor 0.0094 0.089 0.1057
Schistosoma mansoni cathepsin F (C01 family) 0.0138 0.1445 0.1686
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0077 0.0068
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0029 0.0077 0.0068
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0992 0.1181
Plasmodium falciparum serine repeat antigen 4 0.0029 0.0077 0.0391
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Loa Loa (eye worm) calpain family protein 1 0.0112 0.1114 0.133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0271 0.025
Brugia malayi cathepsin L-like cysteine proteinase 0.0029 0.0077 0.0068
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0992 0.1181
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.0077 0.0391
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0271 0.0303
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0068
Echinococcus granulosus cathepsin L cysteine protease 0.0073 0.0631 0.0691
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0281 0.3231 0.392
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0709
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0029 0.0077 0.0391
Echinococcus multilocularis cysteine protease 0.0138 0.1445 0.1402
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0194 0.0211
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0086 0.0795 0.5503
Trypanosoma brucei cysteine peptidase C (CPC) 0.0071 0.0598 0.0702
Schistosoma mansoni peroxidasin 0.0102 0.0992 0.1132
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Giardia lamblia Alanyl dipeptidyl peptidase 0.0086 0.0795 1
Plasmodium falciparum serine repeat antigen 1 0.0029 0.0077 0.0391
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0073 0.0631 0.0691
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0077 0.0531
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0077 0.0068
Echinococcus multilocularis cysteine protease 0.0138 0.1445 0.1402
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0138 0.1445 0.1402
Echinococcus granulosus cathepsin L cysteine proteinase 0.0138 0.1445 0.1686
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1445 0.1753
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0021 0.0026
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.014 0.1468 0.1781
Trypanosoma brucei oligopeptidase b 0.0281 0.3231 0.3905
Loa Loa (eye worm) hypothetical protein 0.0112 0.1114 0.133
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Echinococcus granulosus prolyl endopeptidase 0.0681 0.8243 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0073 0.0631 0.0691
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0631 0.437
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.2723 0.3287
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.0077 0.0391
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Toxoplasma gondii cathepsin CPC1 0.0029 0.0077 0.0068
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0243 0.027
Onchocerca volvulus Dual oxidase homolog 0.0102 0.0992 0.1121
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0243 0.0294
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0604 0.0658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0631 0.0742
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0164 0.1763 0.2075
Loa Loa (eye worm) hypothetical protein 0.0138 0.1445 0.1732
Entamoeba histolytica cysteine protease, putative 0.0029 0.0077 0.0531
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.0077 0.0013
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0243 0.0294
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Onchocerca volvulus 0.0138 0.1445 0.1676
Plasmodium vivax vivapain-2 0.0138 0.1445 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0709
Loa Loa (eye worm) blistered cuticle protein 3 0.0102 0.0992 0.1181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0271 0.025
Plasmodium vivax vivapain-2 0.0138 0.1445 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0138 0.1445 0.1732
Loa Loa (eye worm) calpain family protein 1 0.0082 0.0745 0.0881
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.1763 0.2075
Brugia malayi Cytochrome P450 family protein 0.0038 0.0194 0.0211
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.089 0.6161
Leishmania major cysteine peptidase A (CPA) 0.0138 0.1445 0.1753
Brugia malayi Cathepsin L-like precursor 0.0138 0.1445 0.1732
Onchocerca volvulus 0.0071 0.0604 0.0646
Trypanosoma cruzi kinesin, putative 0.0029 0.0084 0.0102
Trypanosoma cruzi cruzipain precursor, putative 0.0138 0.1445 0.1753
Mycobacterium tuberculosis Probable peptidase 0.0281 0.3231 0.2796
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.014 0.1468 0.1781
Brugia malayi Papain family cysteine protease containing protein 0.0138 0.1445 0.1732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0077 0.0531
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.0077 0.0068
Onchocerca volvulus 0.007 0.0586 0.0624
Plasmodium falciparum importin beta, putative 0.0028 0.0066 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0138 0.1445 1
Entamoeba histolytica hypothetical protein 0.0029 0.0077 0.0531
Brugia malayi beta-lactamase family protein 0.0071 0.0604 0.0709
Echinococcus granulosus cathepsin l cysteine peptidase 0.0138 0.1445 0.1686
Onchocerca volvulus 0.0138 0.1445 0.1676
Loa Loa (eye worm) hypothetical protein 0.0044 0.027 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0271 0.025
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Echinococcus multilocularis cathepsin b 0.0164 0.1763 0.1726
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0068
Echinococcus multilocularis cathepsin L cysteine protease 0.0138 0.1445 0.1402
Loa Loa (eye worm) hypothetical protein 0.0099 0.0956 0.1137
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0604 0.0733
Echinococcus multilocularis snurportin 1 0.03 0.3468 0.346
Plasmodium falciparum serine repeat antigen 6 0.0029 0.0077 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0138 0.1445 1
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0992 0.1181
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0604 0.0658
Toxoplasma gondii prolyl endopeptidase 0.0681 0.8243 1
Onchocerca volvulus 0.0102 0.0992 0.1121
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Trypanosoma cruzi oligopeptidase b 0.0281 0.3231 0.392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0194 0.0236
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0281 0.3231 0.2796
Schistosoma mansoni cathepsin s 0.0044 0.027 0.0248
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0068
Brugia malayi prolyl oligopeptidase family protein 0.0086 0.0795 0.0942
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0243 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.027 0.0302
Loa Loa (eye worm) hypothetical protein 0.0082 0.0745 0.0881
Mycobacterium ulcerans lipase LipD 0.0071 0.0604 0.0418
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0077 0.0531
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.014 0.1468 0.1715
Entamoeba histolytica cysteine proteinase 2 0.0073 0.0631 0.437
Brugia malayi Cathepsin L-like precursor 0.0138 0.1445 0.1732
Echinococcus granulosus cathepsin l1 0.0094 0.089 0.1008
Entamoeba histolytica calpain large subunit domain III containing protein 0.0029 0.0084 0.0582
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Brugia malayi calpain family protein 1 0.0112 0.1114 0.133
Onchocerca volvulus Peroxidasin homolog 0.0102 0.0992 0.1121
Plasmodium falciparum serine repeat antigen 9 0.0029 0.0077 0.0391
Echinococcus granulosus calpain A 0.012 0.122 0.1411
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0316 0.0305
Onchocerca volvulus Prolyl endopeptidase homolog 0.0681 0.8243 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Brugia malayi Cathepsin L-like precursor 0.0138 0.1445 0.1732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0271 0.025
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.2723 0.3287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0795 0.0965
Brugia malayi prolyl oligopeptidase family protein 0.0279 0.3207 0.3875
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.014 0.1468 0.176
Toxoplasma gondii cathepsin B 0.0071 0.0598 0.0702
Onchocerca volvulus Chorion peroxidase homolog 0.0102 0.0992 0.1121
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0604 0.4096
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0604 0.0547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0604 0.0418
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0243 0.0294
Schistosoma mansoni peroxidasin 0.0102 0.0992 0.1132
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0631 0.0742
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0992 0.1181
Plasmodium vivax importin-beta 2, putative 0.0028 0.0066 0.0319
Brugia malayi Importin beta-1 subunit 0.0028 0.0066 0.0055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Echinococcus granulosus snurportin 1 0.03 0.3468 0.416
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.012 0.1217 0.1408
Brugia malayi prolyl oligopeptidase family protein 0.0681 0.8243 1
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.027 0.0327
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0243 0.0216
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0094 0.089 0.108
Plasmodium falciparum cysteine proteinase falcipain 3 0.0138 0.1445 1
Trypanosoma brucei prolyl endopeptidase 0.0681 0.8243 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.089 0.1057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0077 0.0531
Echinococcus granulosus acylamino acid releasing enzyme 0.0086 0.0795 0.0891
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Toxoplasma gondii ABC1 family protein 0.0071 0.0604 0.0709
Onchocerca volvulus 0.0138 0.1445 0.1676
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0077 0.0013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Loa Loa (eye worm) hypothetical protein 0.0044 0.027 0.0302
Mycobacterium ulcerans hypothetical protein 0.0071 0.0604 0.0418
Echinococcus multilocularis hypothetical protein 0.0042 0.0243 0.0179
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Loa Loa (eye worm) hypothetical protein 0.0086 0.0795 0.0942
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0042 0.0243 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0604 0.4182
Schistosoma mansoni cathepsin S (C01 family) 0.0029 0.0077 0.0013
Echinococcus granulosus calpain A 0.0042 0.0243 0.0216
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0795 0.5436
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0029 0.0077 0.0391
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0604 0.4182
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Onchocerca volvulus 0.0138 0.1445 0.1676
Echinococcus granulosus cathepsin L 0.0073 0.0631 0.0691
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0138 0.1445 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.014 0.1468 0.176
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0604 0.4182
Plasmodium falciparum peptidase, putative 0.0086 0.0795 0.5436
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0077 0.0531
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0681 0.8243 1
Leishmania major hypothetical protein, conserved 0.0024 0.0021 0.0026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0709
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0077 0.0093
Giardia lamblia Cathepsin B precursor 0.0071 0.0598 0.726
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0631 0.437
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0604 0.0709
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Onchocerca volvulus Peroxidasin homolog 0.0102 0.0992 0.1121
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0604 0.0709
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Brugia malayi hypothetical protein 0.0102 0.0992 0.1181
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0681 0.8243 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0138 0.1445 1
Loa Loa (eye worm) calpain 0.0042 0.0243 0.027
Entamoeba histolytica cysteine protease, putative 0.0029 0.0077 0.0531
Onchocerca volvulus Cathepsin F homolog 0.0138 0.1445 0.1676
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.012 0.1217 0.1408
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0138 0.1445 0.1402
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0279 0.3207 0.3841
Plasmodium vivax unspecified product 0.0029 0.0077 0.0391
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0029 0.0077 0.0013
Loa Loa (eye worm) fibroinase 0.0138 0.1445 0.1732
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0077 0.0013
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0073 0.0631 0.0766
Brugia malayi cathepsin Z-like cysteine proteinase 0.0029 0.0077 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1445 0.1753
Entamoeba histolytica prolyl oligopeptidase family protein 0.0086 0.0795 0.5503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0709
Plasmodium vivax serine-repeat antigen (SERA) 0.0029 0.0077 0.0391
Plasmodium vivax unspecified product 0.0073 0.0631 0.4286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Echinococcus multilocularis cathepsin L cysteine protease 0.0138 0.1445 0.1402
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0077 0.0531
Echinococcus granulosus cathepsin b 0.0164 0.1763 0.2075
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0243 0.027
Trypanosoma cruzi cysteine proteinase, putative 0.0073 0.0631 0.0766
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0077 0.0068
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0029 0.0077 0.0391
Schistosoma mansoni calpain (C02 family) 0.0042 0.0243 0.0216
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Giardia lamblia Alanyl dipeptidyl peptidase 0.0086 0.0795 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0029 0.0077 0.0531
Leishmania major cytochrome p450-like protein 0.0038 0.0194 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0604 0.0733
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Brugia malayi Peroxidasin 0.0102 0.0992 0.1181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0073 0.0631 0.0742
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Plasmodium vivax vivapain-3 0.0073 0.0631 0.4286
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Loa Loa (eye worm) hypothetical protein 0.0094 0.089 0.1057
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0077 0.0531
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0071 0.0598 0.0726
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.1763 0.2075
Brugia malayi calpain 7 0.0042 0.0243 0.027
Loa Loa (eye worm) calpain 5 0.0029 0.0084 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0077 0.0531
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0992 0.1181
Brugia malayi Papain family cysteine protease containing protein 0.0029 0.0077 0.0068
Trypanosoma cruzi cysteine protease, putative 0.0073 0.0631 0.0766
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0042 0.0243 0.027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0631 0.437
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0604 0.4182
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0029 0.0077 0.0068
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0029 0.0077 0.0013
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0279 0.3207 0.3841
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0086 0.0795 0.0942
Brugia malayi fibroinase precursor 0.0029 0.0077 0.0068
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0029 0.0077 0.0013
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0992 0.1181
Loa Loa (eye worm) hypothetical protein 0.007 0.0586 0.0688
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0029 0.0077 0.0531
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0271 0.0303
Echinococcus granulosus calpain 0.0042 0.0243 0.0216
Brugia malayi cathepsin L precursor 0.0029 0.0077 0.0068
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0068
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0029 0.0077 0.0391
Onchocerca volvulus 0.0138 0.1445 0.1676
Loa Loa (eye worm) CYP4Cod1 0.0038 0.0194 0.0211
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0086 0.0795 0.5503
Trypanosoma cruzi cysteine proteinase, putative 0.0073 0.0631 0.0766
Echinococcus multilocularis prolyl endopeptidase 0.0681 0.8243 0.8317
Entamoeba histolytica protein kinase, putative 0.0029 0.0084 0.0582
Loa Loa (eye worm) hypothetical protein 0.0094 0.089 0.1057
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0992 0.1181
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0279 0.3207 0.3834
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0086 0.0795 0.5503
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0021 0.0026
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.027
Echinococcus granulosus cysteine protease 0.0073 0.0631 0.0691
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0066 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0094 0.089 0.6161
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1445 0.1753
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0029 0.0077 0.0391
Trypanosoma cruzi cysteine peptidase, putative 0.0073 0.0631 0.0766
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0073 0.0631 0.0691
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0821 1 1
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0631 0.437
Entamoeba histolytica cysteine protease, putative 0.0029 0.0077 0.0531
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.0194 0.0211
Loa Loa (eye worm) animal heme peroxidase 0.0102 0.0992 0.1181
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0029 0.0077 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Echinococcus multilocularis cathepsin L 0.0029 0.0077 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Echinococcus granulosus tumor protein p63 0.0328 0.382 0.459
Brugia malayi MH2 domain containing protein 0.024 0.2723 0.3287
Plasmodium vivax calpain, putative 0.0042 0.0243 0.1556
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0029 0.0077 0.0068
Schistosoma mansoni Mername-AA248 (C02 family) 0.0042 0.0243 0.0216
Trypanosoma cruzi cysteine peptidase, putative 0.0138 0.1445 0.1753
Loa Loa (eye worm) hypothetical protein 0.0681 0.8243 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0164 0.1763 0.2139
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.027 0.0327
Onchocerca volvulus 0.0102 0.0992 0.1121
Trypanosoma cruzi kinesin, putative 0.0029 0.0084 0.0102
Toxoplasma gondii cathepsin CPC2 0.0029 0.0077 0.0068
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.012 0.1217 0.1171
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0112 0.1114 0.1281
Echinococcus multilocularis peroxidasin 0.0102 0.0992 0.0942
Loa Loa (eye worm) ctsf protein 0.0138 0.1445 0.1732
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0029 0.0077 0.0531
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0029 0.0077 0.0391
Brugia malayi Cathepsin L-like precursor 0.0138 0.1445 0.1732
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0681 0.8243 1
Trichomonas vaginalis esterase, putative 0.0071 0.0604 0.4182
Plasmodium falciparum serine repeat antigen 8 0.0029 0.0077 0.0391
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Loa Loa (eye worm) prolyl oligopeptidase 0.0279 0.3207 0.3875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.9898 1
Entamoeba histolytica cysteine protease, putative 0.0029 0.0077 0.0531
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0683 0.0805
Entamoeba histolytica cysteine protease, putative 0.0029 0.0077 0.0531
Onchocerca volvulus 0.0138 0.1445 0.1676
Loa Loa (eye worm) hypothetical protein 0.0086 0.0795 0.0942
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0077 0.0013
Onchocerca volvulus Peroxidase homolog 0.0102 0.0992 0.1121
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0077 0.0013
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0066 0.0055
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0029 0.0077 0.0531
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Leishmania major kinesin, putative 0.0029 0.0084 0.0102
Echinococcus granulosus cathepsin b 0.0164 0.1763 0.2075
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0795 0.5503
Echinococcus multilocularis calpain A 0.012 0.122 0.1174
Brugia malayi Cathepsin L-like precursor 0.0044 0.027 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0795 0.0965
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0071 0.0598 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Onchocerca volvulus Cathepsin L homolog 0.0138 0.1445 0.1676
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0604 0.0418
Onchocerca volvulus Peroxidase homolog 0.0102 0.0992 0.1121
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0279 0.3207 0.3195
Brugia malayi Cytochrome P450 family protein 0.0038 0.0194 0.0211
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0029 0.0077 0.0391
Trypanosoma cruzi oligopeptidase b 0.0281 0.3231 0.392
Giardia lamblia Cathepsin B precursor 0.0071 0.0598 0.726
Loa Loa (eye worm) cathepsin B 0.0071 0.0598 0.0702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0271 0.025
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0243 0.027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0316 0.0358
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0029 0.0077 0.0391
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.1445 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.027 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0077 0.0531
Loa Loa (eye worm) hypothetical protein 0.0054 0.0388 0.0446
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0281 0.3231 0.392
Brugia malayi Cathepsin L-like precursor 0.0138 0.1445 0.1732
Trypanosoma cruzi prolyl endopeptidase 0.0681 0.8243 1
Trypanosoma brucei calpain-like protein, putative 0.0042 0.0243 0.027
Schistosoma mansoni cathepsin C 0.0029 0.0077 0.0013
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0138 0.1445 0.1732
Leishmania major hypothetical protein, conserved 0.0071 0.0604 0.0733
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0271 0.0208
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0029 0.0077 0.0013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Brugia malayi hypothetical protein 0.0054 0.0388 0.0446
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0029 0.0077 0.0391
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Plasmodium vivax vivapain-1 0.0073 0.0631 0.4286
Entamoeba histolytica cysteine proteinase 1, putative 0.0073 0.0631 0.437
Brugia malayi calpain 5 0.0029 0.0084 0.0077
Trypanosoma brucei antigen, putative 0.0042 0.0243 0.027
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Schistosoma mansoni calpain-7 (C02 family) 0.0042 0.0243 0.0216
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0029 0.0077 0.0391
Brugia malayi beta-lactamase 0.0071 0.0604 0.0709
Echinococcus multilocularis calpain 0.0042 0.0243 0.0179
Echinococcus multilocularis acylamino acid releasing enzyme 0.0086 0.0795 0.0741
Onchocerca volvulus 0.0094 0.089 0.0996
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Leishmania major oligopeptidase b 0.0281 0.3231 0.392
Entamoeba histolytica cysteine proteinase, putative 0.0138 0.1445 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0086 0.0795 0.5503
Echinococcus granulosus calpain 5 0.0042 0.0243 0.0216
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0271 0.0208
Onchocerca volvulus Cathepsin L homolog 0.0138 0.1445 0.1676
Entamoeba histolytica cysteine proteinase, putative 0.0073 0.0631 0.437
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0086 0.0795 0.0891
Echinococcus multilocularis cathepsin b 0.0164 0.1763 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Echinococcus granulosus cathepsin l1 0.0138 0.1445 0.1686
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0598 0.4141
Brugia malayi Cathepsin L-like cysteine proteinase 0.0094 0.089 0.1057
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0595 0.7163 0.698
Loa Loa (eye worm) hypothetical protein 0.0164 0.1763 0.2119
Toxoplasma gondii cathepsin CPL 0.0138 0.1445 0.1732
Plasmodium falciparum cysteine proteinase falcipain 1 0.0073 0.0631 0.4286
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0029 0.0077 0.0391
Onchocerca volvulus 0.0071 0.0604 0.0646
Echinococcus multilocularis cathepsin L 0.0073 0.0631 0.0575
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0709
Echinococcus granulosus Dipeptidyl peptidase 9 0.014 0.1468 0.1715
Mycobacterium ulcerans beta-lactamase 0.0071 0.0604 0.0418
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.3468 0.4193
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0086 0.0795 0.0942
Onchocerca volvulus 0.0102 0.0992 0.1121
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.0194 0.0236
Brugia malayi cathepsin F-like cysteine proteinase 0.0029 0.0077 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0077 0.0531
Echinococcus multilocularis tumor protein p63 0.0328 0.382 0.3818
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.027 0.0302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0604 0.4182
Brugia malayi RNA, U transporter 1 0.008 0.0715 0.0844
Schistosoma mansoni calpain C (C02 family) 0.0042 0.0243 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0077 0.0531
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0604 0.0709
Trypanosoma cruzi major cysteine proteinase, putative 0.0029 0.0077 0.0093
Onchocerca volvulus 0.0138 0.1445 0.1676
Brugia malayi Papain family cysteine protease containing protein 0.0073 0.0631 0.0742
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Brugia malayi prolyl oligopeptidase family protein 0.014 0.1468 0.176
Loa Loa (eye worm) hypothetical protein 0.0071 0.0604 0.0709
Brugia malayi Blistered cuticle protein 3 0.0102 0.0992 0.1181
Entamoeba histolytica prolyl oligopeptidase family protein 0.0086 0.0795 0.5503
Entamoeba histolytica prolyl oligopeptidase family protein 0.0086 0.0795 0.5503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Onchocerca volvulus 0.0048 0.0316 0.0293
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0077 0.0531
Echinococcus multilocularis Dipeptidyl peptidase 9 0.014 0.1468 0.1426
Loa Loa (eye worm) prolyl oligopeptidase 0.0086 0.0795 0.0942
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0044 0.027 0.0302
Loa Loa (eye worm) hypothetical protein 0.0029 0.0077 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0073 0.0631 0.437
Plasmodium falciparum serine repeat antigen 7 0.0029 0.0077 0.0391
Schistosoma mansoni cathepsin B (C01 family) 0.0029 0.0077 0.0013
Trypanosoma brucei prolyl oligopeptidase, putative 0.0281 0.3231 0.3905
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0281 0.3231 0.2796
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0029 0.0077 0.0531
Echinococcus granulosus cathepsin L 0.0029 0.0077 0.0013
Schistosoma mansoni cathepsin F (C01 family) 0.0094 0.089 0.1008
Plasmodium falciparum serine repeat antigen 2 0.0029 0.0077 0.0391
Brugia malayi cathepsin L-like precursor 0.0094 0.089 0.1057
Plasmodium falciparum serine repeat antigen 3 0.0029 0.0077 0.0391
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Brugia malayi calpain family protein 1 0.0112 0.1114 0.133
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0066 0.0055
Echinococcus multilocularis calpain family protein 1, d 0.0082 0.0745 0.069
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0164 0.1763 0.2075
Brugia malayi beta-lactamase family protein 0.0071 0.0604 0.0709
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0086 0.0795 0.0891
Brugia malayi Animal haem peroxidase family protein 0.0102 0.0992 0.1181
Loa Loa (eye worm) beta-lactamase 0.0071 0.0604 0.0709
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0604 0.0658
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.012 0.1217 0.1408
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0281 0.3231 0.392
Brugia malayi Cytochrome P450 family protein 0.0077 0.0683 0.0805
Entamoeba histolytica cysteine protease, putative 0.0138 0.1445 1
Echinococcus multilocularis calpain 5 0.0042 0.0243 0.0179
Brugia malayi cathepsin B-like cysteine proteinase 0.0164 0.1763 0.2119
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0042 0.0243 0.0294
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Schistosoma mansoni cathepsin F (C01 family) 0.0138 0.1445 0.1686
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0138 0.1445 0.1732
Brugia malayi Cathepsin L-like precursor 0.0094 0.089 0.1057
Brugia malayi prolyl oligopeptidase family protein 0.0086 0.0795 0.0942
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0598 0.065
Trypanosoma brucei cytochrome P450, putative 0.0038 0.0194 0.0211
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0281 0.3231 0.3097
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Loa Loa (eye worm) cysteine protease 0.0138 0.1445 0.1732
Echinococcus granulosus calpain 7 C02 family 0.0042 0.0243 0.0216
Toxoplasma gondii preprocathepsin c precursor, putative 0.0029 0.0077 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0138 0.1445 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0138 0.1445 1
Brugia malayi Cathepsin L-like precursor 0.0138 0.1445 0.1732
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0094 0.089 0.6161
Plasmodium falciparum serine repeat antigen 5 0.0029 0.0077 0.0391
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0029 0.0077 0.0391
Toxoplasma gondii hypothetical protein 0.0086 0.0795 0.0942
Plasmodium vivax unspecified product 0.0044 0.027 0.1745
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0281 0.3231 0.3905
Entamoeba histolytica hypothetical protein, conserved 0.0086 0.0795 0.5503
Entamoeba histolytica cysteine protease, putative 0.0073 0.0631 0.437
Mycobacterium ulcerans proteasome PrcA 0.0821 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0029 0.0077 0.0531
Schistosoma mansoni hypothetical protein 0.03 0.3468 0.416
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0029 0.0077 0.0531
Echinococcus granulosus peroxidasin 0.0102 0.0992 0.1132
Leishmania major cathepsin L-like protease 0.0138 0.1445 0.1753
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0454 0.5398 0.5102
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0029 0.0077 0.0531
Loa Loa (eye worm) hypothetical protein 0.0102 0.0992 0.1181
Entamoeba histolytica cysteine protease, putative 0.0029 0.0077 0.0531
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0042 0.0243 0.0294
Trypanosoma brucei kinesin, putative 0.0029 0.0084 0.0077
Giardia lamblia Cathepsin B precursor 0.0071 0.0598 0.726

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.3 uM In vitro inhibition of DPP-4 ChEMBL. 17194587
IC50 (binding) = 1.3 uM In vitro inhibition of DPP-4 ChEMBL. 17194587
IC50 (binding) > 20 uM In vitro inhibition of DPP-II ChEMBL. 17194587
IC50 (binding) > 20 uM In vitro inhibition of DPP-8 ChEMBL. 17194587
IC50 (binding) > 20 uM In vitro inhibition of FAP, seprase ChEMBL. 17194587
IC50 (binding) > 20 uM In vitro inhibition of DPP-II ChEMBL. 17194587
IC50 (binding) > 20 uM In vitro inhibition of DPP-8 ChEMBL. 17194587
IC50 (binding) > 20 uM In vitro inhibition of FAP, seprase ChEMBL. 17194587

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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