Detailed information for compound 378425

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 4869.45 | Formula: C210H340N62O67S2
  • H donors: 67 H acceptors: 68 LogP: -19.05 Rotable bonds: 206
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)C(C)C)CCC(=O)O)CC(=O)O)CC(C)C)Cc1ccc(cc1)O)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NC(C(=O)C(NC(=O)C(CC(=O)N)N)CC(=O)O)CC(=O)O)CO)CC(=O)O)CC(C)C)Cc1ccccc1)Cc1c[nH]cn1)CC(C)C)CC(C)C)CCCN=C(N)N)CC(=O)N)CCSC)CCC(=O)O)CCSC)C)CCCN=C(N)N)CCC(=O)O)CC(=O)N)CCC(=O)O)CCCN=C(N)N)CCC(=O)O)CCC(=O)N)C)CC(C)C)CC(=O)N)CCCN=C(N)N
  • InChi: 1S/C210H340N62O67S2/c1-26-103(17)162(200(333)249-124(58-64-155(288)289)181(314)258-138(86-148(215)278)193(326)244-122(56-62-153(284)285)178(311)239-116(44-35-69-228-206(219)220)175(308)243-121(55-61-152(282)283)179(312)242-120(54-60-146(213)276)172(305)234-107(21)169(302)232-94-151(281)236-130(77-97(5)6)185(318)259-140(88-150(217)280)192(325)241-117(45-36-70-229-207(221)222)174(307)238-115(43-33-34-68-211)176(309)255-135(83-111-50-52-113(275)53-51-111)189(322)252-133(80-100(11)12)188(321)260-141(91-159(296)297)195(328)245-125(59-65-156(290)291)183(316)265-161(102(15)16)168(218)301)266-182(315)119(47-38-72-231-209(225)226)237-170(303)108(22)235-173(306)126(66-75-340-24)246-180(313)123(57-63-154(286)287)248-201(334)163(104(18)27-2)267-184(317)127(67-76-341-25)247-194(327)139(87-149(216)279)257-177(310)118(46-37-71-230-208(223)224)240-186(319)131(78-98(7)8)251-187(320)132(79-99(9)10)253-191(324)137(84-112-93-227-96-233-112)256-190(323)136(82-110-41-31-30-32-42-110)261-204(337)166(109(23)274)270-197(330)134(81-101(13)14)254-196(329)142(92-160(298)299)262-202(335)164(105(19)28-3)268-198(331)143(95-273)263-203(336)165(106(20)29-4)269-199(332)144-48-39-73-271(144)205(338)145-49-40-74-272(145)210(339)264-129(90-158(294)295)167(300)128(89-157(292)293)250-171(304)114(212)85-147(214)277/h30-32,41-42,50-53,93,96-109,114-145,161-166,273-275H,26-29,33-40,43-49,54-92,94-95,211-212H2,1-25H3,(H2,213,276)(H2,214,277)(H2,215,278)(H2,216,279)(H2,217,280)(H2,218,301)(H,227,233)(H,232,302)(H,234,305)(H,235,306)(H,236,281)(H,237,303)(H,238,307)(H,239,311)(H,240,319)(H,241,325)(H,242,312)(H,243,308)(H,244,326)(H,245,328)(H,246,313)(H,247,327)(H,248,334)(H,249,333)(H,250,304)(H,251,320)(H,252,322)(H,253,324)(H,254,329)(H,255,309)(H,256,323)(H,257,310)(H,258,314)(H,259,318)(H,260,321)(H,261,337)(H,262,335)(H,263,336)(H,264,339)(H,265,316)(H,266,315)(H,267,317)(H,268,331)(H,269,332)(H,270,330)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,296,297)(H,298,299)(H4,219,220,228)(H4,221,222,229)(H4,223,224,230)(H4,225,226,231)/t103-,104-,105-,106-,107-,108-,109?,114?,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128?,129?,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145+,161-,162-,163-,164-,165?,166-/m0/s1
  • InChiKey: YIHRBRJTFIGRRV-MVZVNDLMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Trypanosoma brucei tubulin gamma chain 0.0421 0.1584 0.5271
Echinococcus multilocularis c src tyrosine kinase 0.0024 0.0063 0.0209
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Loa Loa (eye worm) histone methyltransferase 0.001 0.0007 0.0011
Echinococcus granulosus fibroblast growth factor receptor 4 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Echinococcus granulosus tubulin alpha 3 chain 0.058 0.2194 0.731
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Echinococcus granulosus activin receptor type 0.0009 0.0004 0.0013
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni tyrosine kinase 0.0024 0.0063 0.0063
Echinococcus multilocularis epidermal growth factor receptor 0.0009 0.0004 0.0013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0089 0.0282
Schistosoma mansoni nck2/grb4 0.0015 0.0029 0.0029
Entamoeba histolytica tubulin alpha chain, putative 0.058 0.2194 0.7306
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0055 0.0182 0.0592
Treponema pallidum cell division protein FtsZ 0.0183 0.0671 1
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Trypanosoma brucei beta tubulin 0.079 0.3002 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0009 0.0004 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0544 0.2059 0.6853
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0009 0.0004 0.0013
Loa Loa (eye worm) tubulin alpha chain 0.058 0.2194 0.7306
Echinococcus granulosus tubulin alpha chain 0.058 0.2194 0.731
Trichomonas vaginalis tubulin beta chain, putative 0.058 0.2194 0.7306
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0063 0.0063
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0009 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0009 0.0004 0.0013
Echinococcus granulosus Tubulin alpha 1 chain 0.058 0.2194 0.731
Leishmania major beta tubulin 0.079 0.3002 1
Onchocerca volvulus 0.0015 0.0029 0.0288
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0004 0.0013
Trypanosoma brucei beta tubulin 0.079 0.3002 1
Schistosoma mansoni alpha tubulin 0.058 0.2194 0.2194
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0029 0.0098
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Onchocerca volvulus 0.0024 0.0063 0.0668
Schistosoma mansoni tyrosine kinase 0.0024 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Mycobacterium leprae cell division protein FtsZ 0.0183 0.0671 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.058 0.2194 0.731
Echinococcus multilocularis tyrosine protein kinase Abl 0.0024 0.0063 0.0209
Echinococcus granulosus tubulin alpha 0.0421 0.1584 0.5277
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0055 0.0182 0.0605
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0024 0.0063 0.0209
Schistosoma mansoni serine/threonine RGC 0.0009 0.0004 0.0004
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0015 0.0029 0.0098
Echinococcus multilocularis Tubulin beta 2C chain 0.079 0.3002 1
Echinococcus multilocularis tubulin alpha chain 0.058 0.2194 0.731
Echinococcus multilocularis Tubulin alpha 1 chain 0.058 0.2194 0.731
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus multilocularis tubulin alpha chain 0.058 0.2194 0.731
Echinococcus multilocularis protein tyrosine kinase 0.0009 0.0004 0.0013
Brugia malayi cytokine inducible SH2-containing protein 5 0.0015 0.0029 0.0085
Schistosoma mansoni tyrosine kinase 0.0024 0.0063 0.0063
Echinococcus multilocularis tubulin epsilon chain 0.0421 0.1584 0.5277
Echinococcus granulosus hypothetical protein 0.0015 0.0029 0.0098
Echinococcus multilocularis uracil DNA glycosylase 0.0125 0.045 0.1499
Plasmodium vivax polyadenylate-binding protein, putative 0.0009 0.0006 0.0006
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0135 0.049 0.049
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.0884 0.2934
Schistosoma mansoni tubulin subunit epsilon 0.0421 0.1584 0.1584
Echinococcus granulosus tubulin alpha chain 0.058 0.2194 0.731
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Echinococcus granulosus tyrosine kinase 0.0024 0.0063 0.0209
Echinococcus granulosus tubulin beta 1 chain 0.079 0.3002 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0238 0.0884 0.2934
Trichomonas vaginalis tubulin gamma chain, putative 0.0421 0.1584 0.5271
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0029 0.0098
Mycobacterium tuberculosis Cell division protein FtsZ 0.0183 0.0671 1
Trypanosoma cruzi polyadenylate-binding protein 1, putative 0.0009 0.0006 0.0006
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Trichomonas vaginalis tubulin gamma chain, putative 0.0421 0.1584 0.5271
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0009 0.0004 0.0013
Brugia malayi Protein kinase domain containing protein 0.0024 0.0063 0.0196
Echinococcus granulosus expressed conserved protein 0.0015 0.0029 0.0098
Leishmania major beta tubulin 0.079 0.3002 1
Schistosoma mansoni tensin 0.0015 0.0029 0.0029
Brugia malayi tubulin alpha-2 chain 0.058 0.2194 0.7306
Echinococcus multilocularis activated cdc42 kinase 1 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0024 0.0063 0.0209
Loa Loa (eye worm) beta-tubulin 0.079 0.3002 1
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Giardia lamblia Beta tubulin 0.079 0.3002 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0024 0.0063 0.0209
Echinococcus granulosus muscleblind protein 0.031 0.116 0.3865
Brugia malayi Tubulin beta chain 0.0238 0.0884 0.2934
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0015 0.0029 0.0288
Schistosoma mansoni cpg binding protein 0.0033 0.0095 0.0095
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0006 0.0006
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0029 0.0029
Echinococcus granulosus tyrosine protein kinase Src64B 0.0024 0.0063 0.0209
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Echinococcus granulosus GPCR family 2 0.0055 0.0182 0.0605
Leishmania major epsilon tubulin, putative 0.0421 0.1584 0.5271
Trypanosoma brucei zeta tubulin, putative 0.0183 0.0671 0.2226
Echinococcus multilocularis tyrosine protein kinase 0.0009 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0342 0.1281 0.4261
Trichomonas vaginalis tubulin beta chain, putative 0.079 0.3002 1
Trypanosoma cruzi tubulin delta chain 0.0183 0.0671 0.2226
Echinococcus granulosus Eukaryotic translation initiation factor 4H 0.0135 0.049 0.1633
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0024 0.0063 0.0209
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0015 0.0029 0.0098
Trichomonas vaginalis tubulin, putative 0.079 0.3002 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0007 0.0024
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0024 0.0063 0.0209
Echinococcus granulosus tyrosine protein kinase csk 0.0009 0.0004 0.0013
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0009 0.0004 0.0013
Schistosoma mansoni tensin-related 0.0015 0.0029 0.0029
Plasmodium vivax uracil-DNA glycosylase, putative 0.0125 0.045 0.1488
Trichomonas vaginalis tubulin, putative 0.0238 0.0884 0.2934
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0009 0.0004 0.0013
Echinococcus granulosus SH2 motif 0.0015 0.0029 0.0098
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0183 0.0671 0.2226
Mycobacterium ulcerans cell division protein FtsZ 0.0183 0.0671 1
Loa Loa (eye worm) alpha-tubulin 0.058 0.2194 0.7306
Echinococcus granulosus receptor type guanylyl cyclase 0.0009 0.0004 0.0013
Trypanosoma cruzi uracil-DNA glycosylase 0.0125 0.045 0.1488
Echinococcus multilocularis Tubulin beta 2C chain 0.079 0.3002 1
Echinococcus multilocularis tubulin alpha chain 0.058 0.2194 0.731
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0009 0.0004 0.0013
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0009 0.0004 0.0013
Trypanosoma brucei alpha tubulin 0.058 0.2194 0.7306
Echinococcus granulosus alpha tubulin 0.058 0.2194 0.731
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0397 0.1494 0.4969
Plasmodium vivax tubulin alpha chain, putative 0.058 0.2194 0.7306
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0024 0.0063 0.0196
Loa Loa (eye worm) tubulin beta-1 chain 0.079 0.3002 1
Echinococcus multilocularis tubulin delta chain 0.0183 0.0671 0.2236
Trichomonas vaginalis tubulin gamma chain, putative 0.079 0.3002 1
Schistosoma mansoni tubulin subunit delta 0.0183 0.0671 0.0671
Leishmania major poly(A)-binding protein 2 0.0009 0.0006 0.0006
Brugia malayi RhoGAP domain containing protein 0.0015 0.0029 0.0085
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus multilocularis FL cytokine receptor 0.0009 0.0004 0.0013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0425 0.1603 0.5339
Trypanosoma cruzi tubulin delta chain 0.0183 0.0671 0.2226
Echinococcus granulosus protein tyrosine kinase 0.0009 0.0004 0.0013
Brugia malayi Tubulin alpha-2 chain 0.058 0.2194 0.7306
Giardia lamblia Alpha-tubulin 0.058 0.2194 0.7306
Trichomonas vaginalis tubulin alpha chain, putative 0.0238 0.0884 0.2934
Brugia malayi STAT protein, DNA binding domain containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni GTPase activating protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Toxoplasma gondii beta-tubulin, putative 0.079 0.3002 1
Brugia malayi hypothetical protein 0.0024 0.0063 0.0196
Leishmania major gamma-tubulin 0.0421 0.1584 0.5271
Echinococcus granulosus tyrosine protein kinase csk 0.0009 0.0004 0.0013
Trichomonas vaginalis uracil DNA glycosylase, putative 0.0125 0.045 0.1488
Echinococcus multilocularis heat shock protein 70 0.0009 0.0004 0.0013
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.0029 0.0085
Echinococcus granulosus tubulin beta 4A class IVa 0.079 0.3002 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.058 0.2194 0.731
Schistosoma mansoni tubulin subunit alpha 0.058 0.2194 0.2194
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0024 0.0063 0.0209
Echinococcus granulosus Tubulin beta 2C chain 0.079 0.3002 1
Echinococcus granulosus Tubulin alpha 1 chain 0.058 0.2194 0.731
Schistosoma mansoni signal transduction protein lnk-related 0.0015 0.0029 0.0029
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0009 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.0196
Loa Loa (eye worm) tubulin alpha 2 0.0397 0.1494 0.4969
Giardia lamblia Beta tubulin 0.079 0.3002 1
Schistosoma mansoni tyrosine kinase 0.0024 0.0063 0.0063
Onchocerca volvulus 0.0024 0.0063 0.0668
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Trichomonas vaginalis tubulin alpha chain, putative 0.079 0.3002 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0009 0.0004 0.0013
Trichomonas vaginalis tubulin alpha chain, putative 0.0238 0.0884 0.2934
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0015 0.0029 0.0098
Echinococcus multilocularis SH2 motif 0.0015 0.0029 0.0098
Echinococcus granulosus tubulin alpha 1C chain 0.058 0.2194 0.731
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0015 0.0029 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0147 0.0147
Echinococcus multilocularis SH2 domain containing protein 7 0.0015 0.0029 0.0098
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Trichomonas vaginalis tubulin beta chain, putative 0.058 0.2194 0.7306
Brugia malayi SRC-1 0.0024 0.0063 0.0196
Loa Loa (eye worm) hypothetical protein 0.0544 0.2059 0.6853
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0029 0.0085
Entamoeba histolytica tubulin family protein 0.079 0.3002 1
Brugia malayi Tubulin alpha-2 chain 0.058 0.2194 0.7306
Leishmania major beta tubulin 0.079 0.3002 1
Schistosoma mansoni tubulin subunit gamma 0.0421 0.1584 0.1584
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Echinococcus multilocularis Tubulin beta 2C chain 0.079 0.3002 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0015 0.0029 0.0098
Brugia malayi tubulin alpha chain - mouse 0.058 0.2194 0.7306
Plasmodium vivax tubulin alpha chain, putative 0.058 0.2194 0.7306
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0055 0.0182 0.0605
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0015 0.0029 0.0085
Trypanosoma brucei beta tubulin 0.079 0.3002 1
Onchocerca volvulus 0.0024 0.0063 0.0668
Trypanosoma cruzi beta tubulin, putative 0.079 0.3002 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0024 0.0063 0.0209
Brugia malayi tRNA modification GTPase TrmE family protein 0.0015 0.0029 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Echinococcus granulosus tubulin epsilon chain 0.0421 0.1584 0.5277
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Echinococcus granulosus tyrosine protein kinase ABL1 0.0024 0.0063 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Onchocerca volvulus 0.0024 0.0063 0.0668
Plasmodium vivax tubulin gamma chain, putative 0.0421 0.1584 0.5271
Schistosoma mansoni hypothetical protein 0.0015 0.0029 0.0029
Echinococcus multilocularis tensin 0.0015 0.0029 0.0098
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0029 0.0085
Echinococcus granulosus insulin receptor 0.0009 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0055 0.0182 0.0182
Brugia malayi Tensin 0.0015 0.0029 0.0085
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0024 0.0063 0.0209
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0009 0.0004 0.0013
Echinococcus multilocularis epidermal growth factor receptor 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0024 0.0063 0.0209
Echinococcus multilocularis tubulin alpha 3 chain 0.058 0.2194 0.731
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Echinococcus multilocularis tubulin subunit beta 0.079 0.3002 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0009 0.0004 0.0013
Toxoplasma gondii beta-1 tubulin, putative 0.079 0.3002 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0024 0.0063 0.0209
Brugia malayi SH2 domain containing protein 0.0024 0.0063 0.0196
Echinococcus multilocularis tubulin, beta 4A class IVa 0.079 0.3002 1
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Echinococcus granulosus tyrosine protein kinase 0.0009 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Leishmania major beta tubulin 0.079 0.3002 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0475 0.1794 0.1794
Leishmania major delta tubulin, putative 0.0183 0.0671 0.2226
Echinococcus multilocularis peroxisome assembly protein 26 0.058 0.2194 0.731
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis tubulin alpha 3 chain 0.058 0.2194 0.731
Onchocerca volvulus 0.0024 0.0063 0.0668
Echinococcus multilocularis tyrosine protein kinase shark 0.0024 0.0063 0.0209
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0015 0.0029 0.0085
Onchocerca volvulus 0.0238 0.0884 1
Schistosoma mansoni hypothetical protein 0.0119 0.0427 0.0427
Giardia lamblia Alpha-tubulin 0.058 0.2194 0.7306
Echinococcus multilocularis polyadenylate binding protein 0.0009 0.0006 0.0019
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0009 0.0004 0.0013
Entamoeba histolytica tubulin alpha-1 chain 0.058 0.2194 0.7306
Echinococcus multilocularis Tubulin beta 2C chain 0.079 0.3002 1
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Trichomonas vaginalis tubulin beta chain, putative 0.058 0.2194 0.7306
Plasmodium falciparum tubulin epsilon chain, putative 0.0421 0.1584 0.5271
Echinococcus granulosus c src tyrosine kinase 0.0024 0.0063 0.0209
Trypanosoma brucei uracil-DNA glycosylase, putative 0.0125 0.045 0.1488
Echinococcus multilocularis GPCR, family 2 0.0055 0.0182 0.0605
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0147 0.049
Brugia malayi Tubulin beta chain 0.0183 0.0671 0.2226
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0183 0.0671 0.2226
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0009 0.0004 0.0013
Trypanosoma brucei polyadenylate-binding protein 1 0.0009 0.0006 0.0006
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0009 0.0004 0.0004
Echinococcus granulosus N chimaerin 0.0015 0.0029 0.0098
Schistosoma mansoni suppressor of cytokine signaling 0.0015 0.0029 0.0029
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus multilocularis SH2 motif 0.0015 0.0029 0.0098
Echinococcus granulosus SHC transforming protein 3 0.0015 0.0029 0.0098
Trypanosoma brucei beta tubulin 0.079 0.3002 1
Trypanosoma brucei beta tubulin 0.0421 0.1584 0.5271
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Echinococcus granulosus tyrosine protein kinase Srms 0.0024 0.0063 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Echinococcus multilocularis protein KINase family member (kin 25) 0.0009 0.0004 0.0013
Onchocerca volvulus 0.0015 0.0029 0.0288
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus granulosus tubulin delta chain 0.0183 0.0671 0.2236
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0029 0.0085
Trypanosoma cruzi zeta tubulin, putative 0.0183 0.0671 0.2226
Brugia malayi Tubulin gamma chain 0.0421 0.1584 0.5271
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Echinococcus granulosus epidermal growth factor receptor 0.0009 0.0004 0.0013
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0029 0.0085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0174 0.0637 0.2113
Echinococcus multilocularis SH2 motif 0.0015 0.0029 0.0098
Brugia malayi Uracil-DNA glycosylase 0.0125 0.045 0.1488
Echinococcus granulosus beta tubulin 0.079 0.3002 1
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Echinococcus granulosus protein kinase 0.0009 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0055 0.0182 0.0182
Echinococcus multilocularis tubulin alpha 1C chain 0.058 0.2194 0.731
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0009 0.0004 0.0004
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Loa Loa (eye worm) STAT protein 0.0015 0.0029 0.0085
Schistosoma mansoni tensin 0.0015 0.0029 0.0029
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Trichomonas vaginalis tubulin epsilon chain, putative 0.079 0.3002 1
Trichomonas vaginalis tubulin, putative 0.0238 0.0884 0.2934
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0147 0.049
Echinococcus granulosus tyrosine protein kinase shark 0.0024 0.0063 0.0209
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Loa Loa (eye worm) tubulin gamma chain 0.0421 0.1584 0.5271
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0029 0.0029
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0015 0.0029 0.0098
Toxoplasma gondii uracil-DNA glycosylase 0.0125 0.045 0.1488
Giardia lamblia Epsilon tubulin 0.0183 0.0671 0.2226
Trypanosoma cruzi polyadenylate-binding protein, putative 0.0009 0.0006 0.0006
Echinococcus granulosus suppressor of cytokine signaling 6 0.0015 0.0029 0.0098
Leishmania major beta tubulin 0.079 0.3002 1
Schistosoma mansoni protein tyrosine kinase 0.0009 0.0004 0.0004
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine kinase 0.0009 0.0004 0.0013
Schistosoma mansoni tubulin subunit alpha 0.058 0.2194 0.2194
Schistosoma mansoni ephrin receptor 0.0009 0.0004 0.0004
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0009 0.0004 0.0013
Trichomonas vaginalis tubulin, putative 0.0183 0.0671 0.2226
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0009 0.0004 0.0013
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Plasmodium vivax tubulin beta chain, putative 0.079 0.3002 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0421 0.1584 0.5277
Brugia malayi Tubulin beta-1 chain 0.079 0.3002 1
Echinococcus granulosus tyrosine protein kinase pr2 0.0009 0.0004 0.0013
Leishmania major zeta tubulin, putative 0.0183 0.0671 0.2226
Onchocerca volvulus 0.0024 0.0063 0.0668
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0015 0.0029 0.0098
Echinococcus granulosus tubulin alpha 1C chain 0.058 0.2194 0.731
Toxoplasma gondii polyadenylate binding protein, putative 0.0009 0.0006 0.0006
Schistosoma mansoni tensin 0.0015 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni tensin-related 0.0015 0.0029 0.0029
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.058 0.2194 0.7306
Loa Loa (eye worm) tubulin beta chain 0.079 0.3002 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0425 0.1603 0.5339
Loa Loa (eye worm) hypothetical protein 0.058 0.2194 0.7306
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0147 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0671 0.2226
Schistosoma mansoni hypothetical protein 0.0015 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase HCK 0.0009 0.0004 0.0013
Trypanosoma brucei zeta tubulin 0.0183 0.0671 0.2226
Plasmodium falciparum alpha tubulin 1 0.058 0.2194 0.7306
Brugia malayi Tubulin alpha chain 0.0183 0.0671 0.2226
Schistosoma mansoni tubulin subunit beta 0.079 0.3002 0.3002
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0004 0.0013
Loa Loa (eye worm) latrophilin receptor protein 2 0.0055 0.0182 0.0592
Echinococcus multilocularis N chimaerin 0.0015 0.0029 0.0098
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0009 0.0004 0.0013
Leishmania major uracil-DNA-glycosylase, putative 0.0125 0.045 0.1488
Brugia malayi CXXC zinc finger family protein 0.0031 0.0089 0.0282
Echinococcus multilocularis protein kinase 0.0009 0.0004 0.0013
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0004 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Onchocerca volvulus 0.0015 0.0029 0.0288
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0194 0.0635
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Plasmodium falciparum uracil-DNA glycosylase 0.0125 0.045 0.1488
Entamoeba histolytica SH2 domain containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0147 0.0147
Trichomonas vaginalis tubulin epsilon chain, putative 0.079 0.3002 1
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0029 0.0029
Leishmania major beta tubulin 0.079 0.3002 1
Echinococcus granulosus Tubulin beta 2C chain 0.079 0.3002 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0015 0.0029 0.0098
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0029 0.0098
Echinococcus granulosus tyrosine kinase 0.0009 0.0004 0.0013
Trichomonas vaginalis tubulin epsilon chain, putative 0.058 0.2194 0.7306
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0009 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0006 0.0006
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Echinococcus granulosus tubulin subunit TubB 0.058 0.2194 0.731
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0009 0.0004 0.0004
Echinococcus granulosus tubulin subunit beta 0.079 0.3002 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0009 0.0004 0.0013
Echinococcus granulosus tyrosine protein kinase Src42A 0.0024 0.0063 0.0209
Echinococcus multilocularis integrin linked protein kinase 0.0009 0.0004 0.0013
Brugia malayi polyadenylate-binding protein 1 0.0009 0.0006 0.0006
Trichomonas vaginalis tubulin epsilon chain, putative 0.0183 0.0671 0.2226
Echinococcus granulosus tubulin alpha chain 0.058 0.2194 0.731
Echinococcus multilocularis natriuretic peptide receptor 1 0.0009 0.0004 0.0013
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0024 0.0063 0.0209
Echinococcus granulosus SH2 motif 0.0015 0.0029 0.0098
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Echinococcus granulosus dnaJ subfamily B 0.0438 0.1652 0.5502
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0024 0.0063 0.0209
Schistosoma mansoni uracil-DNA glycosylase 0.0125 0.045 0.045
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Loa Loa (eye worm) tubulin alpha-2 chain 0.058 0.2194 0.7306
Echinococcus granulosus tyrosine protein kinase HCK 0.0009 0.0004 0.0013
Echinococcus granulosus raf serine:threonine protein kinase 0.0009 0.0004 0.0013
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0009 0.0004 0.0013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0183 0.0671 0.2226
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0238 0.0884 0.2934
Leishmania major beta tubulin 0.079 0.3002 1
Onchocerca volvulus 0.0015 0.0029 0.0288
Toxoplasma gondii alpha tubulin TUBA1 0.058 0.2194 0.7306
Trichomonas vaginalis tubulin beta chain, putative 0.058 0.2194 0.7306
Echinococcus granulosus retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Brugia malayi Protein kinase domain containing protein 0.0024 0.0063 0.0196
Echinococcus multilocularis Tubulin beta 2C chain 0.079 0.3002 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0183 0.0671 0.2226
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0147 0.0477
Trichomonas vaginalis tubulin beta chain, putative 0.058 0.2194 0.7306
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0009 0.0004 0.0013
Echinococcus multilocularis tubulin alpha chain 0.058 0.2194 0.731
Echinococcus granulosus polyadenylate binding protein 0.0009 0.0006 0.0019
Giardia lamblia Delta tubulin 0.0183 0.0671 0.2226
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0015 0.0029 0.0085
Entamoeba histolytica protein kinase, putative 0.0015 0.0029 0.0085
Loa Loa (eye worm) SRC-1 0.0024 0.0063 0.0196
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0009 0.0004 0.0004
Echinococcus granulosus suppressor of cytokine signaling 7 0.0015 0.0029 0.0098
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0015 0.0029 0.0288
Loa Loa (eye worm) tubulin alpha 2 0.0159 0.0581 0.1924
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Plasmodium falciparum polyadenylate-binding protein, putative 0.0009 0.0006 0.0006
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0029 0.0085
Echinococcus granulosus ephrin type A receptor 4 A 0.0009 0.0004 0.0013
Giardia lamblia Beta tubulin 0.079 0.3002 1
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Loa Loa (eye worm) tubulin alpha 2 0.0397 0.1494 0.4969
Onchocerca volvulus 0.0015 0.0029 0.0288
Leishmania major beta tubulin 0.079 0.3002 1
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis muscleblind protein 0.031 0.116 0.3865
Trypanosoma brucei epsilon tubulin 0.0421 0.1584 0.5271
Loa Loa (eye worm) uracil-DNA glycosylase 0.0125 0.045 0.1488
Echinococcus granulosus activated cdc42 kinase 1 0.0009 0.0004 0.0013
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0006 0.0006
Schistosoma mansoni tubulin subunit beta 0.079 0.3002 0.3002
Schistosoma mansoni tubulin subunit beta 0.079 0.3002 0.3002
Echinococcus multilocularis cpg binding protein 0.0033 0.0095 0.0318
Echinococcus granulosus peroxisome assembly protein 26 0.058 0.2194 0.731
Echinococcus granulosus tyrosine protein kinase Src42A 0.0015 0.0029 0.0098
Loa Loa (eye worm) TK protein kinase 0.0024 0.0063 0.0196
Schistosoma mansoni tubulin subunit alpha 0.058 0.2194 0.2194
Echinococcus granulosus epidermal growth factor receptor 0.0009 0.0004 0.0013
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0015 0.0029 0.0098
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Trypanosoma brucei alpha tubulin 0.058 0.2194 0.7306
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Trichomonas vaginalis tubulin epsilon chain, putative 0.058 0.2194 0.7306
Schistosoma mansoni cpg binding protein 0.0031 0.0089 0.0089
Loa Loa (eye worm) TK/FER protein kinase 0.0024 0.0063 0.0196
Echinococcus granulosus Tubulin alpha 1 chain 0.058 0.2194 0.731
Echinococcus multilocularis tubulin subunit TubB 0.058 0.2194 0.731
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0015 0.0029 0.0098
Echinococcus granulosus NCK adaptor protein 0.0015 0.0029 0.0098
Echinococcus multilocularis Eukaryotic translation initiation factor 4H 0.0135 0.049 0.1633
Echinococcus granulosus Tubulin beta 2C chain 0.079 0.3002 1
Schistosoma mansoni hypothetical protein 0.0055 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0397 0.1494 0.4969
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Brugia malayi Tyrosine-protein kinase abl-1 0.0024 0.0063 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0147 0.049
Loa Loa (eye worm) BEN-1 protein 0.079 0.3002 1
Schistosoma mansoni tubulin subunit beta 0.0183 0.0671 0.0671
Echinococcus multilocularis tubulin alpha 1C chain 0.058 0.2194 0.731
Echinococcus multilocularis tyrosine protein kinase Srms 0.0024 0.0063 0.0209
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0004
Schistosoma mansoni alpha tubulin 0.058 0.2194 0.2194
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) SH2 domain-containing protein 0.0015 0.0029 0.0085
Loa Loa (eye worm) tubulin beta chain 0.0183 0.0671 0.2226
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Leishmania major beta tubulin 0.079 0.3002 1
Loa Loa (eye worm) tubulin beta-4 chain 0.079 0.3002 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0182 0.0592
Echinococcus multilocularis 0.0015 0.0029 0.0098
Echinococcus granulosus tyrosine protein kinase Lyn 0.0024 0.0063 0.0209
Onchocerca volvulus 0.0031 0.0089 0.0962
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0221 0.0221
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Brugia malayi hypothetical protein 0.0015 0.0029 0.0085
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0007 0.0009
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0009 0.0004 0.0013
Brugia malayi Protein kinase domain containing protein 0.0024 0.0063 0.0196
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0024 0.0063 0.0209
Echinococcus multilocularis activin receptor type 0.0009 0.0004 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0147 0.0477
Entamoeba histolytica tubulin family protein 0.079 0.3002 1
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0015 0.0029 0.0029
Echinococcus granulosus cpg binding protein 0.0033 0.0095 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Entamoeba histolytica uracil-DNA glycosylase, putative 0.0125 0.045 0.1488
Schistosoma mansoni ephrin receptor 0.0009 0.0004 0.0004
Plasmodium vivax delta tubulin, putative 0.0183 0.0671 0.2226
Loa Loa (eye worm) BEN-1 protein 0.079 0.3002 1
Trypanosoma brucei alpha tubulin 0.058 0.2194 0.7306
Schistosoma mansoni tubulin subunit beta 0.079 0.3002 0.3002
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0029 0.0085
Chlamydia trachomatis uracil DNA glycosylase 0.0125 0.045 0.5
Brugia malayi alpha-tubulin 0.058 0.2194 0.7306
Plasmodium falciparum alpha tubulin 2 0.058 0.2194 0.7306
Trypanosoma brucei alpha tubulin, putative 0.0238 0.0884 0.2934
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0029 0.0085
Echinococcus granulosus tyrosine kinase 0.0024 0.0063 0.0209
Leishmania major poly(A)-binding protein 3 0.0009 0.0006 0.0006
Echinococcus granulosus natriuretic peptide receptor 1 0.0009 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0119 0.0427 0.1409
Trypanosoma brucei epsilon tubulin 0.0421 0.1584 0.5271
Echinococcus multilocularis beta tubulin 0.079 0.3002 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0009 0.0004 0.0013
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0029 0.0085
Trypanosoma brucei alpha tubulin 0.058 0.2194 0.7306
Schistosoma mansoni polyadenylate binding protein 0.0009 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0024 0.0063 0.0196
Schistosoma mansoni tyrosine protein kinase 0.0009 0.0004 0.0004
Trypanosoma cruzi tubulin gamma chain 0.0421 0.1584 0.5271
Echinococcus granulosus signal transduction protein lnk realted 0.0015 0.0029 0.0098
Echinococcus granulosus activated cdc42 kinase 1 0.0009 0.0004 0.0013
Giardia lamblia Gamma tubulin 0.0421 0.1584 0.5271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0147 0.0147
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0024 0.0063 0.0209
Echinococcus multilocularis transfer RNA-Thr 0.0009 0.0004 0.0013
Echinococcus granulosus beta tubulin 0.079 0.3002 1
Trypanosoma cruzi alpha tubulin, putative 0.058 0.2194 0.7306
Trypanosoma cruzi zeta tubulin, putative 0.0183 0.0671 0.2226
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0015 0.0029 0.0098
Loa Loa (eye worm) alpha-tubulin 0.058 0.2194 0.7306
Loa Loa (eye worm) tubulin alpha-3 chain 0.0342 0.1281 0.4261
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0397 0.1494 0.4969
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Echinococcus multilocularis tyrosine protein kinase Blk 0.0024 0.0063 0.0209
Schistosoma mansoni tubulin subunit alpha 0.0183 0.0671 0.0671
Schistosoma mansoni cpg binding protein 0.0033 0.0095 0.0095
Echinococcus granulosus integrin linked protein kinase 0.0009 0.0004 0.0013
Schistosoma mansoni suppressor of cytokine signaling 0.0015 0.0029 0.0029
Schistosoma mansoni alpha tubulin 0.058 0.2194 0.2194
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Trypanosoma brucei epsilon tubulin 0.0421 0.1584 0.5271
Echinococcus granulosus tubulin alpha chain 0.058 0.2194 0.731
Echinococcus granulosus uracil DNA glycosylase 0.0125 0.045 0.1499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0174 0.0637 0.2113
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0029 0.0098
Echinococcus multilocularis tyrosine kinase 0.0024 0.0063 0.0209
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Loa Loa (eye worm) TK/ABL protein kinase 0.0024 0.0063 0.0196
Plasmodium falciparum tubulin delta chain, putative 0.0183 0.0671 0.2226
Echinococcus granulosus tyrosine protein kinase csk 0.0009 0.0004 0.0013
Toxoplasma gondii alpha-tubulin I, putative 0.058 0.2194 0.7306
Brugia malayi protein-tyrosine kinase 0.0024 0.0063 0.0196
Echinococcus granulosus Tubulin beta 2C chain 0.079 0.3002 1
Echinococcus multilocularis muscleblind protein 1 0.031 0.116 0.3865
Loa Loa (eye worm) hypothetical protein 0.031 0.116 0.3857
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0421 0.1584 0.5271
Echinococcus multilocularis dnaJ subfamily B 0.0438 0.1652 0.5502
Schistosoma mansoni G/t mismatch-specific thymine DNA glycosylase 0.0125 0.045 0.045
Echinococcus granulosus tubulin alpha chain 0.058 0.2194 0.731
Loa Loa (eye worm) tubulin beta-2A chain 0.079 0.3002 1
Brugia malayi Latrophilin receptor protein 2 0.0055 0.0182 0.0592
Toxoplasma gondii beta tubulin 0.079 0.3002 1
Schistosoma mansoni shc transforming protein 0.0015 0.0029 0.0029
Onchocerca volvulus 0.0015 0.0029 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0004 0.0004
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0135 0.049 0.049
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Brugia malayi SH2 domain containing protein 0.0024 0.0063 0.0196
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Echinococcus granulosus retinal guanylyl cyclase 2 0.0009 0.0004 0.0013
Echinococcus multilocularis insulin receptor 0.0009 0.0004 0.0013
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0009 0.0004 0.0004
Echinococcus multilocularis hypothetical protein 0.058 0.2194 0.731
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0009 0.0004 0.0013
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis raf serine:threonine protein kinase 0.0009 0.0004 0.0013
Trichomonas vaginalis tubulin gamma chain, putative 0.0183 0.0671 0.2226
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0063 0.0209
Brugia malayi latrophilin 2 splice variant baaae 0.0119 0.0427 0.1409
Schistosoma mansoni protein kinase 0.0009 0.0004 0.0004
Trypanosoma brucei tubulin delta chain 0.0183 0.0671 0.2226
Plasmodium falciparum tubulin beta chain 0.079 0.3002 1
Trypanosoma brucei polyadenylate-binding protein 2 0.0009 0.0006 0.0006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0029 0.0098
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0015 0.0029 0.0098
Entamoeba histolytica tubulin gamma chain 0.0421 0.1584 0.5271
Brugia malayi Cell division protein ftsZ 0.0183 0.0671 0.2226
Echinococcus multilocularis tubulin beta 1 chain 0.079 0.3002 1
Leishmania major alpha tubulin 0.058 0.2194 0.7306
Trichomonas vaginalis tubulin beta chain, putative 0.058 0.2194 0.7306
Trypanosoma cruzi epsilon tubulin, putative 0.0421 0.1584 0.5271
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0015 0.0029 0.0085
Echinococcus granulosus kinase suppressor of Ras 1 0.0009 0.0004 0.0013
Schistosoma mansoni hypothetical protein 0.0438 0.1652 0.1652
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis receptor type guanylyl cyclase 0.0009 0.0004 0.0013
Schistosoma mansoni vav2 0.0015 0.0029 0.0029
Echinococcus granulosus SH2 domain containing adapter protein F 0.0015 0.0029 0.0098
Plasmodium falciparum tubulin gamma chain 0.0421 0.1584 0.5271
Echinococcus multilocularis SHC transforming protein 3 0.0015 0.0029 0.0098
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0009 0.0004 0.0013
Brugia malayi Protein kinase domain containing protein 0.0024 0.0063 0.0196
Schistosoma mansoni hypothetical protein 0.0055 0.0182 0.0182
Entamoeba histolytica hypothetical protein, conserved 0.0125 0.045 0.1488
Echinococcus multilocularis tensin 0.0015 0.0029 0.0098
Schistosoma mansoni SH2A 0.0015 0.0029 0.0029
Echinococcus granulosus tubulin gamma 1 chain 0.0421 0.1584 0.5277
Brugia malayi Tubulin alpha chain 0.058 0.2194 0.7306
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0183 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0085
Plasmodium vivax tubulin epsilon chain, putative 0.0421 0.1584 0.5271
Loa Loa (eye worm) tubulin alpha chain 0.058 0.2194 0.7306
Echinococcus multilocularis beta tubulin 0.079 0.3002 1
Echinococcus granulosus tubulin alpha 3 chain 0.058 0.2194 0.731
Echinococcus granulosus tensin 0.0015 0.0029 0.0098
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Brugia malayi SH2 domain containing protein 0.0015 0.0029 0.0085
Schistosoma mansoni adapter molecule crk 0.0015 0.0029 0.0029
Schistosoma mansoni tyrosine kinase 0.0024 0.0063 0.0063
Echinococcus multilocularis tubulin alpha chain 0.058 0.2194 0.731
Loa Loa (eye worm) hypothetical protein 0.0135 0.049 0.1622
Brugia malayi RNA binding protein 0.0135 0.049 0.1622
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0015 0.0029 0.0029
Echinococcus multilocularis protein kinase 0.0009 0.0004 0.0013
Leishmania major beta tubulin 0.079 0.3002 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0421 0.1584 0.5271
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0342 0.1281 0.4261
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Echinococcus multilocularis tubulin alpha 0.0421 0.1584 0.5277
Echinococcus granulosus Tubulin beta 2C chain 0.079 0.3002 1
Schistosoma mansoni tubulin subunit beta 0.079 0.3002 0.3002
Leishmania major beta tubulin 0.079 0.3002 1
Schistosoma mansoni eukaryotic translation initiation factor 4h 0.0135 0.049 0.049
Schistosoma mansoni tubulin subunit beta 0.079 0.3002 0.3002
Schistosoma mansoni tyrosine kinase 0.0009 0.0004 0.0004
Trypanosoma cruzi epsilon tubulin, putative 0.0421 0.1584 0.5271
Brugia malayi beta-tubulin, identical 0.079 0.3002 1
Schistosoma mansoni tyrosine kinase 0.0024 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.031 0.116 0.3857
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0007 0.0024
Echinococcus granulosus SH2 domain containing protein 7 0.0015 0.0029 0.0098
Brugia malayi Muscleblind-like protein 0.031 0.116 0.3857
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0015 0.0029 0.0098
Leishmania major beta tubulin 0.079 0.3002 1

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 1.5 nM Activity of peptidic agonists on h-CRF2-alpha receptor using agonist-stimulated adenylate cyclase assay ChEMBL. 10794681
EC50 (functional) = 6.3 nM Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay ChEMBL. 10794681
Ki (binding) = 1.07 nM Binding affinity of the receptor corticotropin releasing factor receptor with peptidic agonists ChEMBL. 10794681
Ki (binding) = 1.26 nM Binding affinity of the receptor h-CRF2-alpha with peptidic agonists ChEMBL. 10794681

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.