Detailed information for compound 378744

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1599.87 | Formula: C78H102N16O17S2
  • H donors: 20 H acceptors: 17 LogP: -0.38 Rotable bonds: 23
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H]1NC(=O)[C@@H](N)CSSCC(NC(=O)[C@@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@H](NC(=O)[C@H](NC1=O)CC(=O)N)Cc1ccccc1)Cc1ccccc1)Cc1c[nH]c2c1cccc2)Cc1ccc(cc1)CNC(C)C)[C@H](O)C)[C@H](O)C)C(=O)O
  • InChi: 1S/C78H102N16O17S2/c1-43(2)82-38-50-29-27-49(28-30-50)35-58-73(105)93-65(44(3)96)76(108)90-59(34-48-22-12-7-13-23-48)74(106)94-66(45(4)97)77(109)91-62(40-95)75(107)92-63(78(110)111)42-113-112-41-53(80)67(99)84-55(26-16-17-31-79)68(100)89-61(37-64(81)98)72(104)86-56(32-46-18-8-5-9-19-46)69(101)85-57(33-47-20-10-6-11-21-47)70(102)88-60(71(103)87-58)36-51-39-83-54-25-15-14-24-52(51)54/h5-15,18-25,27-30,39,43-45,53,55-63,65-66,82-83,95-97H,16-17,26,31-38,40-42,79-80H2,1-4H3,(H2,81,98)(H,84,99)(H,85,101)(H,86,104)(H,87,103)(H,88,102)(H,89,100)(H,90,108)(H,91,109)(H,92,107)(H,93,105)(H,94,106)(H,110,111)/t44-,45-,53-,55-,56-,57+,58+,59+,60-,61+,62+,63?,65-,66-/m1/s1
  • InChiKey: WKARXRIKHNCPRX-LRIFCIRKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0007 0.0007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0072 0.0395 0.0788
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0116 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0116 0.0231
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0016 0.0031
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0007 0.0009
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0048 0.0226 0.5018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0116 0.0229
Schistosoma mansoni rab6-interacting 0.0039 0.0167 0.021
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0048 0.0226 1
Schistosoma mansoni notch 0.0017 0.0007 0.0009
Schistosoma mansoni neuropeptide receptor 0.0017 0.0007 0.0009
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0116 0.0116
Schistosoma mansoni metabotropic glutamate receptor 0.0072 0.0395 0.0495
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0414 0.0414
Brugia malayi bZIP transcription factor family protein 0.0083 0.0472 0.0941
Entamoeba histolytica heat shock protein 90, putative 0.0078 0.0441 0.9853
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Toxoplasma gondii microneme protein, putative 0.002 0.0031 0.0113
Schistosoma mansoni peroxidasin 0.0052 0.0254 0.0319
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Brugia malayi Protein kinase domain containing protein 0.0016 0.0005 0.001
Plasmodium falciparum conserved protein, unknown function 0.0125 0.077 1
Loa Loa (eye worm) hypothetical protein 0.0125 0.077 0.1536
Echinococcus multilocularis heat shock protein 90 0.003 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Schistosoma mansoni pyruvate dehydrogenase 0.0679 0.4675 0.586
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0441 0.0878
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Brugia malayi Cadherin domain containing protein 0.0017 0.0007 0.0013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0116 0.0116
Onchocerca volvulus 0.0052 0.0254 0.2805
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0139 0.0868 0.0868
Echinococcus multilocularis glutamate receptor 2 0.014 0.0876 0.0876
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Schistosoma mansoni notch 0.0017 0.0007 0.0009
Echinococcus granulosus heat shock protein 90 0.0078 0.0441 0.0441
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0007 0.0007
Echinococcus multilocularis heat shock protein 90 0.0078 0.0441 0.0441
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0009 0.0018
Toxoplasma gondii PAN/Apple domain-containing protein 0.002 0.0031 0.0113
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0125 0.077 0.077
Brugia malayi metabotropic glutamate receptor type 2 0.0072 0.0395 0.0787
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Echinococcus granulosus tumor protein p63 0.0366 0.2469 0.2469
Onchocerca volvulus 0.002 0.0031 0.0266
Toxoplasma gondii PAN domain-containing protein 0.0312 0.2085 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0116 0.0116
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0007 0.0009
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0104 0.0206
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0007 0.0007
Mycobacterium ulcerans two component sensor kinase MprB 0.0048 0.0226 0.0933
Brugia malayi Delta serrate ligand family protein 0.0017 0.0007 0.0013
Echinococcus multilocularis dnaJ subfamily B 0.041 0.2774 0.2774
Onchocerca volvulus 0.0065 0.0347 0.3859
Toxoplasma gondii PAN domain-containing protein 0.002 0.0031 0.0113
Schistosoma mansoni DNA topoisomerase II 0.0048 0.0226 0.0283
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.014 0.0876 0.0876
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0007 0.0009
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0007 0.0013
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0048 0.0226 0.0933
Echinococcus multilocularis glutamate receptor subunit protein glur 0.014 0.0876 0.0876
Entamoeba histolytica hypothetical protein 0.0072 0.0395 0.7754
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0116 0.0145
Echinococcus multilocularis slit 2 protein 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0048 0.0226 0.0528
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.001 0.0019
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0007 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0246 0.5487
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis protein jagged 1 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0039 0.0167 0.0333
Brugia malayi ecdysteroid receptor 0.0032 0.0116 0.0229
Schistosoma mansoni neuropeptide receptor 0.0017 0.0007 0.0009
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0017 0.0007 0.0009
Echinococcus multilocularis microtubule associated protein 2 0.0691 0.4757 0.4757
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0116 0.123
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0018 0.0014 0.0028
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0048 0.0226 0.0528
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0246 0.115
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0267 0.0335
Brugia malayi PAS domain containing protein 0.0066 0.0354 0.0704
Echinococcus granulosus hypothetical protein 0.0017 0.0007 0.0007
Echinococcus granulosus cpg binding protein 0.003 0.0103 0.0103
Onchocerca volvulus 0.0039 0.0167 0.1819
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0001 0.0001
Giardia lamblia Grp94/Hsp90 0.003 0.0104 0.2229
Echinococcus multilocularis glutamate receptor 2 0.0072 0.0395 0.0395
Echinococcus multilocularis glutamate receptor 2 0.0212 0.1381 0.1381
Echinococcus multilocularis neuropeptide receptor A26 0.0017 0.0007 0.0007
Schistosoma mansoni glutamate receptor AMPA 0.014 0.0876 0.1098
Onchocerca volvulus 0.0072 0.0395 0.4402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0116 0.0231
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0246 0.0309
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) chitinase I 0.0079 0.0444 0.0886
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0167 0.0334
Entamoeba histolytica heat shock protein 90, putative 0.0078 0.0441 0.9853
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0007 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0116 0.0116
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0116 0.0116
Loa Loa (eye worm) TOPoisomerase family member 0.0048 0.0226 0.0451
Trypanosoma cruzi DNA topoisomerase II, putative 0.0048 0.0226 0.045
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0007 0.0007
Trichomonas vaginalis DNA topoisomerase II, putative 0.0048 0.0226 0.5018
Loa Loa (eye worm) glutamate receptor 1 0.014 0.0876 0.1747
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0104 0.0206
Brugia malayi Serotonin receptor 0.0017 0.0007 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0009 0.0011
Plasmodium vivax DNA gyrase subunit B, putative 0.0048 0.0226 0.0974
Echinococcus granulosus sex peptide receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0125 0.0771 0.1539
Leishmania major protein kinase, putative 0.0018 0.0016 0.0031
Brugia malayi ORL1-like opioid receptor 0.0017 0.0007 0.0013
Brugia malayi small heat shock protein 0.0569 0.3899 0.778
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0007 0.0013
Mycobacterium tuberculosis Conserved protein 0.0048 0.0226 0.0528
Schistosoma mansoni tyrosine kinase 0.0072 0.0395 0.0495
Loa Loa (eye worm) hypothetical protein 0.0067 0.0362 0.0723
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0226 0.1053
Brugia malayi MAP kinase sur-1 0.0051 0.0246 0.049
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0007 0.0007
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0254 0.0506
Leishmania major protein kinase, putative 0.0018 0.0016 0.0031
Echinococcus multilocularis transfer RNA-Lys 0.0049 0.0233 0.0233
Echinococcus granulosus neuropeptide s receptor 0.0017 0.0007 0.0007
Brugia malayi bHLH-PAS transcription factor 0.0049 0.0233 0.0464
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0359 0.2417 1
Loa Loa (eye worm) heat shock protein 90 0.0078 0.0441 0.0879
Echinococcus multilocularis jun protein 0.0083 0.0472 0.0472
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0246 0.049
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0007 0.0007
Onchocerca volvulus 0.0032 0.0116 0.123
Onchocerca volvulus Putative endochitinase 0.0079 0.0444 0.4957
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0246 0.0246
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0007 0.0007
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0246 0.049
Loa Loa (eye worm) hypothetical protein 0.0125 0.0767 0.1531
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0007 0.0007
Toxoplasma gondii microneme protein MIC17C 0.002 0.0031 0.0113
Brugia malayi Probable DNA topoisomerase II 0.0048 0.0226 0.045
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0116 0.0229
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0048 0.0226 1
Echinococcus granulosus metabotropic glutamate receptor 2 0.0072 0.0395 0.0395
Schistosoma mansoni calcium-activated potassium channel 0.0045 0.0206 0.0258
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0125 0.077 0.077
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus granulosus RUN 0.0039 0.0167 0.0167
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0007 0.0015
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0007 0.0007
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0048 0.0226 0.5018
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0018
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0007 0.0009
Echinococcus multilocularis NMDA receptor 0.014 0.0876 0.0876
Chlamydia trachomatis glutamine binding protein 0.0359 0.2417 1
Echinococcus granulosus jun protein 0.0083 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0048 0.0226 0.5018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0092 0.0183
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0018 0.0014 0.0014
Giardia lamblia Heat shock protein HSP 90-alpha 0.003 0.0104 0.2229
Echinococcus granulosus glutamate NMDA receptor subunit 0.014 0.0876 0.0876
Loa Loa (eye worm) glutamate receptor 0.0072 0.0395 0.0788
Onchocerca volvulus Putative endochitinase 0.0088 0.0511 0.5716
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0125 0.077 0.1535
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0048 0.0226 0.045
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0007 0.0015
Plasmodium falciparum DNA topoisomerase 2 0.0048 0.0226 0.0974
Toxoplasma gondii subtilisin SUB12 0.002 0.0031 0.0113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Schistosoma mansoni opsin-like receptor 0.0017 0.0007 0.0009
Echinococcus granulosus neuropeptide receptor 0.0017 0.0007 0.0007
Echinococcus granulosus protein jagged 1 0.0017 0.0007 0.0007
Echinococcus multilocularis mitogen activated protein kinase 14 0.0125 0.0767 0.0767
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0048 0.0226 0.5018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0116 0.0229
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0116 0.0116
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.014 0.0876 0.0876
Brugia malayi Melatonin receptor type 1A 0.0017 0.0007 0.0013
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0042 0.0184 0.0366
Echinococcus granulosus fibropellin Ia 0.0017 0.0007 0.0007
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0007 0.0007
Trichomonas vaginalis sensor histidine kinase, putative 0.0048 0.0226 0.5018
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Echinococcus granulosus potassium large conductance calcium activated 0.0045 0.0206 0.0206
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0254 0.2805
Mycobacterium tuberculosis Possible two component sensor kinase 0.0048 0.0226 0.0528
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0116 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0116 0.0231
Echinococcus granulosus glutamate receptor 2 0.0072 0.0395 0.0395
Schistosoma mansoni notch 0.0017 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.014 0.0876 0.1098
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0007 0.0009
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.001 0.0019
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0048 0.0226 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Brugia malayi hypothetical protein 0.0072 0.0395 0.0787
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0009 0.0009
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0254 0.0506
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0116 0.0229
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Echinococcus multilocularis protein jagged 2 0.0017 0.0007 0.0007
Brugia malayi putative neuropeptide receptor 0.0017 0.0007 0.0013
Schistosoma mansoni pyruvate dehydrogenase 0.0679 0.4675 0.586
Onchocerca volvulus 0.0049 0.0237 0.2608
Brugia malayi endochitinase 0.0079 0.0444 0.0884
Brugia malayi nuclear receptor RXR 0.0017 0.0009 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0048 0.0226 0.045
Brugia malayi hypothetical protein 0.0017 0.0009 0.0016
Brugia malayi endochitinase 0.0088 0.0511 0.1018
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0048 0.0226 0.5018
Onchocerca volvulus 0.002 0.0031 0.0266
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0074 0.0414 0.0824
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0104 0.0104
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0065 0.0347 0.0551
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0122 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis mitogen activated protein kinase 11 0.0125 0.0767 0.0767
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0104 0.0206
Loa Loa (eye worm) RGC/RGC protein kinase 0.0072 0.0395 0.0788
Echinococcus multilocularis nmda type glutamate receptor 0.1435 1 1
Onchocerca volvulus Putative endochitinase 0.0088 0.0511 0.5716
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.0456 0.0911
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus granulosus protein jagged 1 0.0017 0.0007 0.0007
Echinococcus multilocularis nuclear factor of activated T cells 5 0.008 0.0452 0.0452
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0167 0.0167
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Trichomonas vaginalis heat shock protein, putative 0.003 0.0104 0.218
Schistosoma mansoni lipoxygenase 0.0111 0.0668 0.0837
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0251 0.1661 0.7958
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0031 0.0061
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0167 0.0167
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0226 0.0451
Brugia malayi steroid hormone receptor 0.0032 0.0116 0.0229
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0727 0.5012 0.5012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus granulosus neural cadherin 0.0017 0.0007 0.0007
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0048 0.0226 0.2484
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0007 0.0007
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0072 0.0395 0.0395
Echinococcus granulosus delta-like protein 1 0.0017 0.0007 0.0007
Giardia lamblia Heat shock protein HSP 90-alpha 0.0078 0.0441 1
Toxoplasma gondii microneme protein MIC4 0.002 0.0031 0.0113
Schistosoma mansoni glutamate receptor kainate 0.014 0.0876 0.1098
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0359 0.2417 1
Toxoplasma gondii PAN domain-containing protein 0.002 0.0031 0.0113
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0212 0.1381 0.1381
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0116 0.0145
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0001 0.0001
Onchocerca volvulus 0.002 0.0031 0.0266
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0116 0.0231
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0048 0.0226 0.0528
Leishmania major extracellular receptor, putative 0.0072 0.0395 0.0787
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0246 0.049
Echinococcus multilocularis cpg binding protein 0.003 0.0103 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0116 0.0229
Loa Loa (eye worm) hypothetical protein 0.0727 0.5012 1
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Echinococcus granulosus neuropeptide receptor A26 0.0017 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0029 0.0092 0.0115
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0007 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0007 0.0007
Schistosoma mansoni glutamate receptor NMDA 0.1148 0.7978 1
Brugia malayi Glutamate receptor 1 precursor 0.014 0.0876 0.1746
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0116 0.0116
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Brugia malayi Blistered cuticle protein 3 0.0052 0.0254 0.0506
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0007 0.0007
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0212 0.1381 0.1381
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0472 0.0472
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0246 0.049
Schistosoma mansoni endoplasmin 0.0078 0.0441 0.0552
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0007 0.0007
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0254 0.0506
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Onchocerca volvulus 0.0052 0.0254 0.2805
Echinococcus multilocularis fibropellin Ia 0.0017 0.0007 0.0007
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0167 0.0167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0116 0.0229
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.014 0.0876 0.0876
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0009 0.0016
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0116 0.0145
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0246 0.0246
Plasmodium vivax hypothetical protein, conserved 0.0125 0.077 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0048 0.0226 0.0528
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0116 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0251 0.1661 0.3313
Mycobacterium ulcerans DNA gyrase subunit B 0.0048 0.0226 0.0933
Schistosoma mansoni septate junction protein 0.0017 0.0007 0.0009
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Schistosoma mansoni notch 0.0017 0.0007 0.0009
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0048 0.0226 0.0974
Mycobacterium tuberculosis Possible chitinase 0.0067 0.0362 0.1116
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0048 0.0226 0.0528
Plasmodium falciparum heat shock protein 90 0.0078 0.0441 0.4536
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0048 0.0226 0.0528
Schistosoma mansoni amine GPCR 0.0017 0.0007 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0319 0.04
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus granulosus protein jagged 2 0.0017 0.0007 0.0007
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0007 0.0007
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.014 0.0876 0.0876
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0111 0.0668 0.0668
Toxoplasma gondii 1,3(4)-beta-glucanase 0.002 0.0031 0.0113
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0048 0.0226 0.0528
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0007 0.000000072253
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0007 0.0015
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0116 0.0145
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Echinococcus granulosus notch 0.0017 0.0007 0.0007
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0226 0.0974
Schistosoma mansoni heat shock protein 0.0078 0.0441 0.0552
Onchocerca volvulus 0.002 0.0031 0.0266
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0007 0.0007
Onchocerca volvulus Peroxidase homolog 0.0052 0.0254 0.2805
Brugia malayi hypothetical protein 0.0039 0.0167 0.0333
Echinococcus multilocularis calcium activated potassium channel variant 0.0042 0.0184 0.0184
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0048 0.0226 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) microfilarial chitinase 0.0077 0.0429 0.0856
Echinococcus granulosus mitogen activated protein kinase 14 0.0125 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0018 0.0014 0.0014
Schistosoma mansoni jun-related protein 0.0067 0.0363 0.0455
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0359 0.2417 1
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Leishmania major chitinase 0.0079 0.0444 0.0884
Trypanosoma cruzi extracellular receptor, putative 0.0072 0.0395 0.0787
Echinococcus multilocularis neuropeptide s receptor 0.0017 0.0007 0.0007
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0007 0.0007
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0116 0.123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0116 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Leishmania major developmentally regulated phosphoprotein-like protein 0.0727 0.5012 1
Mycobacterium ulcerans heat shock protein 90 0.003 0.0104 0.0427
Schistosoma mansoni retinoic acid receptor RXR 0.0139 0.0868 0.1088
Onchocerca volvulus 0.0142 0.0888 1
Schistosoma mansoni heat shock protein 0.0078 0.0441 0.0552
Echinococcus multilocularis receptor type guanylyl cyclase 0.0072 0.0395 0.0395
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0007 0.0009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0569 0.3899 0.778
Schistosoma mansoni microtubule-associated protein tau 0.0691 0.4757 0.5963
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0007 0.0007
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.003 0.01 0.0197
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0048 0.0226 0.045
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0017 0.0007 0.0009
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0048 0.0226 0.0933
Onchocerca volvulus Putative endochitinase 0.0088 0.0511 0.5716
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0116 0.0116
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0212 0.1381 0.1381
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Brugia malayi Endoplasmin precursor 0.0078 0.0441 0.0878
Trichomonas vaginalis heat shock protein, putative 0.0078 0.0441 1
Plasmodium vivax DNA topoisomerase II, putative 0.0048 0.0226 0.0974
Trypanosoma cruzi heat shock protein 90, putative 0.0063 0.033 0.0658
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0441 0.0878
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0254 0.0506
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0246 0.049
Schistosoma mansoni cpg binding protein 0.003 0.0103 0.013
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0727 0.5012 0.5012
Schistosoma mansoni opsin-like receptor 0.0017 0.0007 0.0009
Echinococcus granulosus dnaJ subfamily B 0.041 0.2774 0.2774
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0007 0.0015
Plasmodium falciparum DNA gyrase subunit B 0.0048 0.0226 0.0974
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0007 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0246 0.0491
Schistosoma mansoni notch 0.0017 0.0007 0.0009
Entamoeba histolytica hypothetical protein 0.0074 0.0414 0.8619
Onchocerca volvulus 0.0072 0.0395 0.4402
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0048 0.0226 0.0226
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0074 0.0414 0.8619
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0116 0.0229
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0007 0.0007
Brugia malayi Cadherin domain containing protein 0.0017 0.0007 0.0013
Echinococcus granulosus heat shock protein 0.0078 0.0441 0.0441
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0167 0.0167
Echinococcus granulosus g protein coupled receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0048 0.0226 0.045
Brugia malayi hypothetical protein 0.0065 0.0347 0.0691
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0125 0.0767 0.1529
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0072 0.0395 0.0788
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Onchocerca volvulus 0.0125 0.077 0.8656
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni cell polarity protein 0.0017 0.0007 0.0009
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis glutamate receptor NMDA 0.0936 0.6486 0.6486
Echinococcus granulosus single minded 2 0.0049 0.0233 0.0233
Onchocerca volvulus 0.0052 0.0254 0.2805
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0359 0.2417 1
Schistosoma mansoni metabotropic glutamate receptor 0.0072 0.0395 0.0495
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0246 0.5487
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0072 0.0395 0.0787
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0199
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0048 0.0226 0.045
Entamoeba histolytica chitinase, putative 0.0079 0.0444 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0008 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0031 0.0061
Toxoplasma gondii DNA topoisomerase 2, putative 0.0048 0.0226 0.1053
Schistosoma mansoni tyrosine kinase 0.0072 0.0395 0.0495
Echinococcus multilocularis serotonin receptor 0.0017 0.0007 0.0007
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0007 0.0013
Mycobacterium ulcerans chitinase/cellulase 0.0067 0.0362 0.1496
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0007 0.0015
Echinococcus granulosus fmrfamide receptor 0.0017 0.0007 0.0007
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0116 0.0229
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0116 0.0231
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Brugia malayi Guanylyl cyclase protein 23 0.0072 0.0395 0.0787
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0007 0.0007
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0007 0.0007
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0048 0.0226 0.0933
Echinococcus multilocularis serotonin receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0125 0.077 0.1536
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0116 0.0145
Schistosoma mansoni calcium-activated potassium channel 0.0042 0.0184 0.023
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0254 0.2805
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0116 0.0145
Schistosoma mansoni slit 0.0017 0.0007 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0116 0.0231
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0072 0.0395 0.4402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0116 0.0229
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0048 0.0226 0.0933
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Echinococcus multilocularis mitogen activated protein kinase 11 0.0125 0.0767 0.0767
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0116 0.0145
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0072 0.0395 0.0395
Giardia lamblia Pms1-like protein 0.0048 0.0226 0.5049
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Mycobacterium tuberculosis Probable two component sensor kinase 0.0048 0.0226 0.0528
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0246 0.0246
Brugia malayi nuclear receptor NHR-88 0.0032 0.0116 0.0229
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0212 0.1381 0.1381
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0116 0.123
Mycobacterium ulcerans two component regulator - sensor kinase 0.0048 0.0226 0.0933
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0031 0.0061
Brugia malayi Dopamine receptor protein 2 0.0017 0.0007 0.0013
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0048 0.0226 0.0933
Echinococcus multilocularis notch 0.0017 0.0007 0.0007
Echinococcus granulosus glutamate receptor NMDA 0.0936 0.6486 0.6486
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0007 0.0007
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0048 0.0226 0.1053
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Brugia malayi Dopamine receptor protein 1 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Echinococcus granulosus nuclear factor of activated T cells 5 0.008 0.0452 0.0452
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Echinococcus granulosus serotonin receptor 0.0017 0.0007 0.0007
Schistosoma mansoni amine GPCR 0.0017 0.0007 0.0009
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0017 0.001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0048 0.0226 0.0451
Entamoeba histolytica hypothetical protein 0.0074 0.0414 0.8619
Schistosoma mansoni glutamate receptor kainate 0.014 0.0876 0.1098
Toxoplasma gondii microneme protein MIC17B 0.002 0.0031 0.0113
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0116 0.0116
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0359 0.2417 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0111 0.0668 0.0668
Echinococcus granulosus heat shock protein 90 0.003 0.0104 0.0104
Echinococcus granulosus microtubule associated protein 2 0.0691 0.4757 0.4757
Echinococcus multilocularis nmda type glutamate receptor 0.1008 0.6991 0.6991
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0007 0.0007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0116 0.0116
Echinococcus granulosus aryl hydrocarbon receptor 0.0142 0.0892 0.0892
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0007 0.0013
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Echinococcus multilocularis tyrosine kinase 0.0072 0.0395 0.0395
Echinococcus multilocularis calcium activated potassium channel 0.0046 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0007 0.0013
Toxoplasma gondii heat shock protein 90, putative 0.0078 0.0441 0.2085
Brugia malayi notch-like transmembrane receptor 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0048 0.0226 0.0933
Schistosoma mansoni histamine h1 receptor 0.0017 0.0007 0.0009
Echinococcus granulosus receptor type guanylyl cyclase 0.0072 0.0395 0.0395
Brugia malayi Glutamate receptor 2 precursor 0.014 0.0876 0.1746
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0499 0.3404 0.3404
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0048 0.0226 0.045
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0007 0.0013
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0048 0.0226 0.0933
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Schistosoma mansoni adenoreceptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Onchocerca volvulus Peroxidase homolog 0.0052 0.0254 0.2805
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0007 0.0007
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0007 0.0013
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0048 0.0226 0.045
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Schistosoma mansoni neuropeptide receptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni hypothetical protein 0.041 0.2774 0.3478
Schistosoma mansoni opsin-like receptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.001 0.002
Mycobacterium ulcerans chitinase/cellulase 0.0067 0.0362 0.1496
Onchocerca volvulus Putative endochitinase 0.0079 0.0444 0.4957
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0116 0.0116
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0031 0.0061
Echinococcus granulosus orexin receptor type 2 0.0017 0.0007 0.0007
Brugia malayi Serotonin receptor 0.0017 0.0007 0.0013
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0246 0.5515
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Echinococcus granulosus glutamate receptor 2 0.0212 0.1381 0.1381
Brugia malayi Metabotropic glutamate receptor precursor. 0.0072 0.0395 0.0787
Brugia malayi GnHR receptor homolog 0.0017 0.0007 0.0013
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0116 0.0116
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0273 0.1279
Schistosoma mansoni lipoxygenase 0.0039 0.0167 0.021
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0007 0.0009
Schistosoma mansoni ATP-binding cassette transporter 0.014 0.0876 0.1098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0125 0.0767 0.153
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0212 0.1381 0.1381
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0116 0.0116
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0007 0.0007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0414 0.0414
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0016 0.0031
Onchocerca volvulus 0.002 0.0031 0.0266
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0007 0.0007
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0254 0.0506
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0125 0.0767 0.1529
Loa Loa (eye worm) hypothetical protein 0.0142 0.0888 0.1772
Brugia malayi Dopamine receptor 0.0017 0.0007 0.0013
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0116 0.0116
Echinococcus multilocularis neural cadherin 0.0017 0.0007 0.0007
Schistosoma mansoni glutamate receptor NMDA 0.014 0.0876 0.1098
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0048 0.0226 0.0226
Loa Loa (eye worm) PAN domain-containing protein 0.002 0.0031 0.0061
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Onchocerca volvulus 0.0125 0.077 0.8656
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0007 0.0015
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0254 0.0507
Echinococcus granulosus tyrosine kinase 0.0072 0.0395 0.0395
Brugia malayi Endochitinase 0.0088 0.0511 0.1018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0212 0.1381 0.1381
Onchocerca volvulus 0.002 0.0031 0.0266
Echinococcus granulosus calcium activated potassium channel 0.0046 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0116 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0254 0.0507
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0007 0.0007
Echinococcus granulosus peroxidasin 0.0052 0.0254 0.0254
Echinococcus granulosus mitogen activated protein kinase 11 0.0125 0.0767 0.0767
Mycobacterium ulcerans putative regultory protein 0.0048 0.0226 0.0933
Echinococcus granulosus g protein coupled receptor 0.0017 0.0007 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Echinococcus multilocularis somatostatin receptor 0.0017 0.0007 0.0007
Brugia malayi P38 map kinase family protein 2 0.0125 0.0767 0.1529
Echinococcus multilocularis RUN 0.0039 0.0167 0.0167
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0226 0.2484
Brugia malayi hypothetical protein 0.0017 0.0009 0.0016
Schistosoma mansoni glutamate receptor kainate 0.014 0.0876 0.1098
Brugia malayi G-protein coupled receptor 0.0017 0.0007 0.0013
Onchocerca volvulus 0.0054 0.0267 0.2948
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0007 0.0009
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0007 0.0009
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0727 0.5012 1
Brugia malayi heat shock protein 90 0.0078 0.0441 0.0878
Leishmania major DNA topoisomerase ii 0.0048 0.0226 0.045
Brugia malayi neuropeptide F receptor 0.0017 0.0007 0.0013
Schistosoma mansoni pyruvate dehydrogenase 0.0727 0.5012 0.6282
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0007 0.0013
Trichomonas vaginalis heat shock protein, putative 0.003 0.0104 0.218
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Onchocerca volvulus 0.002 0.0031 0.0266
Schistosoma mansoni single-minded 0.0066 0.0354 0.0443
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Loa Loa (eye worm) Notch2 0.0017 0.0007 0.0014
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0246 0.049
Trypanosoma cruzi heat shock protein 85, putative 0.0078 0.0441 0.0878
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0007 0.0007
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0116 0.0229
Schistosoma mansoni coup transcription factor 0.0032 0.0116 0.0145
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.003 0.01 0.0199
Echinococcus granulosus slit 2 protein 0.0017 0.0007 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0009 0.0016
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Trypanosoma cruzi DNA topoisomerase II, putative 0.0048 0.0226 0.045
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0246 0.0246
Schistosoma mansoni amine GPCR 0.0017 0.0007 0.0009
Schistosoma mansoni endoplasmin 0.0078 0.0441 0.0552
Brugia malayi Receptor family ligand binding region containing protein 0.0072 0.0395 0.0787
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0048 0.0226 0.0528
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0007 0.0007
Echinococcus multilocularis heat shock protein 0.0078 0.0441 0.0441
Echinococcus granulosus somatostatin receptor 0.0017 0.0007 0.0007
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0009 0.0011
Brugia malayi AKH receptor 0.0017 0.0007 0.0013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0116 0.0145
Schistosoma mansoni peroxidasin 0.0052 0.0254 0.0319
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0007 0.0007
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0125 0.0767 0.153
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0212 0.1381 0.1381
Trypanosoma brucei heat shock protein 90, putative 0.0078 0.0441 0.0878
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0048 0.0226 0.0528
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0007 0.0007
Brugia malayi G protein-coupled receptor 0.0017 0.0007 0.0013
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0007 0.0007
Schistosoma mansoni glutamate receptor AMPA 0.014 0.0876 0.1098
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0007 0.0007
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Trypanosoma brucei Heat shock protein 83, putative 0.0078 0.0441 0.0878
Echinococcus granulosus atrial natriuretic peptide receptor 0.0072 0.0395 0.0395
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Schistosoma mansoni protein kinase 0.0072 0.0395 0.0495
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0007 0.0009
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0048 0.0226 0.0528
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0007 0.0007
Leishmania major mitochondrial DNA topoisomerase II 0.0048 0.0226 0.045
Trypanosoma cruzi Heat shock protein 83, putative 0.0078 0.0441 0.0878
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Trichomonas vaginalis endoplasmin, putative 0.0063 0.0336 0.7582
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0048 0.0226 0.0933
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0001 0.0001
Echinococcus granulosus glutamate receptor subunit protein glur 0.014 0.0876 0.0876
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Onchocerca volvulus 0.0029 0.0092 0.0961
Toxoplasma gondii microneme protein MIC17A 0.002 0.0031 0.0113
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0072 0.0395 0.0395
Schistosoma mansoni rab6-interacting 0.0039 0.0167 0.021
Onchocerca volvulus 0.002 0.0031 0.0266
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Toxoplasma gondii PAN domain-containing protein 0.002 0.0031 0.0113
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0116 0.0231
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0246 0.049
Leishmania major hypothetical protein, conserved 0.0048 0.0226 0.045
Mycobacterium leprae Probable two-component sensor kinase 0.0048 0.0226 1
Mycobacterium ulcerans putative regulatory protein 0.0049 0.0233 0.0961
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Toxoplasma gondii hypothetical protein 0.0125 0.077 0.3669
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0299 0.1998 0.9578
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0167 0.0334
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0251 0.1661 0.3313
Plasmodium vivax endoplasmin, putative 0.0078 0.0441 0.4536
Schistosoma mansoni aryl hydrocarbon receptor 0.0191 0.1236 0.1549
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus granulosus endoplasmin 0.003 0.0104 0.0104
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0007 0.0015
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0072 0.0395 0.0788
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Brugia malayi Receptor family ligand binding region containing protein 0.0072 0.0395 0.0787
Plasmodium falciparum endoplasmin, putative 0.0063 0.0336 0.2807
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0007 0.0007
Brugia malayi sulfakinin receptor protein 0.0017 0.0007 0.0013
Schistosoma mansoni loxhd1 0.0039 0.0167 0.021
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Trypanosoma brucei developmentally regulated phosphoprotein 0.0727 0.5012 1
Echinococcus granulosus protein jagged 2 0.0017 0.0007 0.0007
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0007 0.0013
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0007 0.0007
Brugia malayi RE15519p 0.0017 0.0007 0.0013
Brugia malayi G-protein coupled receptor 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0061
Loa Loa (eye worm) cuticular endochitinase 0.0079 0.0444 0.0886
Schistosoma mansoni cpg binding protein 0.003 0.0103 0.013
Loa Loa (eye worm) glutamate receptor 2 0.014 0.0876 0.1747
Trypanosoma brucei DNA topoisomerase ii 0.0048 0.0226 0.045
Echinococcus granulosus metabotropic glutamate receptor 5 0.0072 0.0395 0.0395
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0116 0.0229
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Trichomonas vaginalis receptor histidine kinase, putative 0.0048 0.0226 0.5018
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0007 0.0009
Echinococcus multilocularis tumor protein p63 0.0366 0.2469 0.2469
Loa Loa (eye worm) notch protein 0.0017 0.0007 0.0014
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0007 0.0013
Echinococcus granulosus neuropeptide receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0072 0.0395 0.0788
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0018
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0246 0.5487
Brugia malayi nuclear hormone receptor 0.0032 0.0116 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0018
Echinococcus multilocularis peroxidasin 0.0052 0.0254 0.0254
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0007 0.0015
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0254 0.2805
Schistosoma mansoni polycystin 1-related 0.0039 0.0167 0.021
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0048 0.0226 0.0528
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0054 0.0267 0.0533
Echinococcus granulosus allatostatin A receptor 0.0017 0.0007 0.0007
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0007 0.0007
Schistosoma mansoni notch 0.0017 0.0007 0.0009
Toxoplasma gondii heat shock protein HSP90 0.0078 0.0441 0.2085
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0254 0.2805
Brugia malayi EGF-like domain containing protein 0.0017 0.0007 0.0013
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0226 0.2484
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0116 0.0229
Onchocerca volvulus 0.002 0.0031 0.0266
Schistosoma mansoni biogenic amine receptor 0.0017 0.0007 0.0009
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0231
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Echinococcus multilocularis aryl hydrocarbon receptor 0.0142 0.0892 0.0892
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Toxoplasma gondii PAN domain-containing protein 0.002 0.0031 0.0113
Schistosoma mansoni biogenic amine receptor 0.0017 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0018
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0727 0.5012 0.5012
Schistosoma mansoni hypothetical protein 0.0125 0.077 0.0965
Loa Loa (eye worm) hypothetical protein 0.0039 0.0167 0.0334
Toxoplasma gondii hypothetical protein 0.002 0.0031 0.0113
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0104 0.4345
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0125 0.0767 0.1529
Echinococcus multilocularis sex peptide receptor 0.0017 0.0007 0.0007
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0251 0.1661 0.3313
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Trichomonas vaginalis heat shock protein, putative 0.0063 0.0336 0.7582
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0007 0.0007
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0007 0.0015
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0072 0.0395 0.0788
Brugia malayi neuropeptide F receptor 0.0017 0.0007 0.0013
Brugia malayi hypothetical protein 0.0017 0.001 0.0019
Trypanosoma cruzi heat shock protein 90, putative 0.0078 0.0441 0.0878
Schistosoma mansoni hypothetical protein 0.0039 0.0167 0.021
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0009 0.0009
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0007 0.0007
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0018 0.0016 0.0031
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0212 0.1381 0.1381
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0048 0.0226 1
Brugia malayi Peroxidasin 0.0052 0.0254 0.0506
Echinococcus multilocularis endoplasmin 0.003 0.0104 0.0104
Onchocerca volvulus 0.002 0.0031 0.0266
Echinococcus multilocularis mitogen activated protein kinase 14 0.0125 0.0767 0.0767
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0116 0.0116
Brugia malayi CXXC zinc finger family protein 0.0029 0.0092 0.0182
Onchocerca volvulus 0.002 0.0031 0.0266
Trichomonas vaginalis receptor histidine kinase, putative 0.0048 0.0226 0.5018
Schistosoma mansoni biogenic amine receptor 0.0017 0.0007 0.0009
Toxoplasma gondii PAN domain-containing protein 0.0312 0.2085 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Mycobacterium leprae Probable two component sensor kinase MprB 0.0048 0.0226 1
Trypanosoma brucei heat shock protein, putative 0.0078 0.0441 0.0878
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Brugia malayi larval opioid receptor 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0072 0.0395 0.0788
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0125 0.0767 0.1529
Trypanosoma brucei protein kinase, putative 0.0051 0.0246 0.049
Loa Loa (eye worm) endoplasmin 0.0078 0.0441 0.0879
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0246 0.5487
Brugia malayi Muscle positioning protein 4 0.0017 0.0007 0.0013
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0007 0.0007
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0254 0.0507
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0007 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0007 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0414 0.0519
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0007 0.0009
Echinococcus granulosus nmda type glutamate receptor 0.1008 0.6991 0.6991
Schistosoma mansoni amine GPCR 0.0017 0.0007 0.0009
Brugia malayi hypothetical protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Schistosoma mansoni hypothetical protein 0.0074 0.0414 0.0519
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0116 0.0229
Trichomonas vaginalis heat shock protein, putative 0.003 0.0104 0.218
Loa Loa (eye worm) hypothetical protein 0.0052 0.0254 0.0507
Schistosoma mansoni hypothetical protein 0.0067 0.0363 0.0455
Echinococcus granulosus calcium activated potassium channel variant 0.0042 0.0184 0.0184
Onchocerca volvulus 0.0039 0.0167 0.1819
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0048 0.0226 0.0528
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0007 0.0007
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0007 0.0009
Brugia malayi Doublecortin family protein 0.0039 0.0167 0.0333
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0007 0.0007
Toxoplasma gondii hypothetical protein 0.002 0.0031 0.0113
Entamoeba histolytica hypothetical protein 0.0074 0.0414 0.8619
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Leishmania major heat shock protein 83-1 0.0078 0.0441 0.0878
Brugia malayi PAN domain containing protein 0.002 0.0031 0.006
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0007 0.0009
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Echinococcus multilocularis protein jagged 1 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.014 0.0876 0.0876
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0007 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0116 0.0145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0116 0.0231
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0048 0.0226 0.0528
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0007 0.0009
Echinococcus granulosus g protein coupled receptor 0.0017 0.0007 0.0007
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0018 0.0016 0.0031
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0048 0.0226 0.045
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0007 0.0015
Brugia malayi hypothetical protein 0.0052 0.0254 0.0506
Trypanosoma brucei heat shock protein 90, putative 0.0078 0.0441 0.0878
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0007 0.0013
Echinococcus multilocularis potassium large conductance calcium activated 0.0045 0.0206 0.0206
Brugia malayi kinase, mitochondrial precursor 0.0727 0.5012 1
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0009
Schistosoma mansoni myosin xvIII 0.0017 0.0007 0.0009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0007 0.0009
Plasmodium vivax heat shock protein 86, putative 0.0078 0.0441 0.4536
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0014
Echinococcus granulosus glutamate receptor ionotropic kainate 0.014 0.0876 0.0876
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 443 nM Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 1. ChEMBL. 11405660
IC50 (binding) > 1000 nM Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 2. ChEMBL. 11405660
IC50 (binding) > 10000 nM Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 3. ChEMBL. 11405660
IC50 (binding) > 10000 nM Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 4. ChEMBL. 11405660
IC50 (binding) > 10000 nM Tested for ability to bind to 20 microM thick cryostat sections of a membrane pellet of cells transfected with human cloned somatostatin (sst) receptor subtype 5. ChEMBL. 11405660

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.