Detailed information for compound 400222

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1199.45 | Formula: C57H78N14O11S2
  • H donors: 15 H acceptors: 11 LogP: 0.6 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N)CCCN=C(N)N)NC(=O)[C@H]1CSSC(C)(C)[C@@H](NC(=O)[C@H](Cc2ccc(cc2)O)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1)Cc1ccccc1)CO)[C@H](c1ccc2c(c1)cccc2)C
  • InChi: 1S/C57H78N14O11S2/c1-32(36-21-20-35-14-7-8-15-37(35)28-36)46-54(81)64-29-45(74)65-43(30-72)52(79)68-42(27-33-12-5-4-6-13-33)51(78)69-44(53(80)67-41(16-9-10-24-58)50(77)66-40(48(60)75)17-11-25-63-56(61)62)31-83-84-57(2,3)47(55(82)70-46)71-49(76)39(59)26-34-18-22-38(73)23-19-34/h4-8,12-15,18-23,28,32,39-44,46-47,72-73H,9-11,16-17,24-27,29-31,58-59H2,1-3H3,(H2,60,75)(H,64,81)(H,65,74)(H,66,77)(H,67,80)(H,68,79)(H,69,78)(H,70,82)(H,71,76)(H4,61,62,63)/t32-,39-,40-,41-,42+,43-,44+,46-,47-/m0/s1
  • InChiKey: HWTDVIKHJPOWJP-WISPORKVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus receptor type guanylyl cyclase 0.0112 0.0327 0.0327
Echinococcus granulosus metabotropic glutamate receptor 5 0.0111 0.0323 0.0323
Echinococcus granulosus RUN 0.0042 0.0112 0.0112
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0769 0.2355 0.2355
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0109 0.0319 0.031
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0074 0.2793
Echinococcus granulosus neuropeptide s receptor 0.001 0.0012 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0012 0.0012
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0014 0.0004
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi G-protein coupled receptor 0.001 0.0012 0.0002
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0013
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0012 0.0012
Echinococcus multilocularis receptor type guanylyl cyclase 0.0112 0.0327 0.0327
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0074 0.0074
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0109 0.0319 0.031
Schistosoma mansoni adapter molecule crk 0.0009 0.001 0.001
Schistosoma mansoni pcd6 interacting protein-related 0.0109 0.0319 0.0319
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.0112 0.0112
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0039 0.053
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0039 0.053
Brugia malayi mbt repeat family protein 0.0046 0.0125 0.0116
Loa Loa (eye worm) TK protein kinase 0.0041 0.0109 0.0099
Echinococcus multilocularis glutamate receptor 2 0.0216 0.0648 0.0648
Echinococcus granulosus allatostatin A receptor 0.001 0.0012 0.0012
Echinococcus granulosus dnaJ subfamily B 0.0437 0.1331 0.1331
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0039 0.0039
Schistosoma mansoni cpg binding protein 0.0032 0.0082 0.0082
Loa Loa (eye worm) glutamate receptor 0.0111 0.0323 0.0314
Schistosoma mansoni ap endonuclease 0.0018 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0042 0.0112 0.0102
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Brugia malayi protein-tyrosine kinase 0.0041 0.0109 0.0099
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.3248 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0064
Brugia malayi G protein-coupled receptor 0.001 0.0012 0.0002
Onchocerca volvulus 0.0109 0.0319 0.4495
Brugia malayi SRC-1 0.0045 0.0122 0.0113
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0014 0.0014
Brugia malayi Serotonin receptor 0.001 0.0012 0.0002
Schistosoma mansoni neuropeptide receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus granulosus sex peptide receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0109 0.0319 0.0319
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0014 0.0014
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0125 0.166
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0216 0.0648 0.0648
Echinococcus granulosus g-protein coupled receptor 0.001 0.0012 0.0012
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0122 0.0122
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0125 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0074 0.0074
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0111 0.0323 0.0314
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0015 0.0015
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0114 0.0333 0.0324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0009 0.001 0.001
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0039 0.0538
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Schistosoma mansoni opsin-like receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0039 0.0506
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0074 0.0074
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0327 0.0989 0.0989
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0327 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0109 0.0319 0.031
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0012 0.0002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0039 0.0029
Echinococcus granulosus glutamate receptor subunit protein glur 0.0216 0.0648 0.0648
Loa Loa (eye worm) MBCTL1 0.0053 0.0145 0.0136
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0333 0.0333
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0327 0.0989 0.0989
Brugia malayi Receptor family ligand binding region containing protein 0.0112 0.0327 0.0318
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0012 0.0012
Echinococcus multilocularis serotonin receptor 0.001 0.0012 0.0012
Brugia malayi ORL1-like opioid receptor 0.001 0.0012 0.0002
Brugia malayi sulfakinin receptor protein 0.001 0.0012 0.0002
Entamoeba histolytica protein kinase, putative 0.0036 0.0095 0.1967
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Brugia malayi Protein-tyrosine phosphatase 1 0.0109 0.0319 0.031
Schistosoma mansoni lipoxygenase 0.0042 0.0112 0.0112
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0077 0.0067
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0216 0.0648 0.0648
Onchocerca volvulus 0.0109 0.0319 0.4495
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0012 0.0012
Echinococcus granulosus glutamate receptor 2 0.0111 0.0323 0.0323
Schistosoma mansoni amine GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0122 0.0122
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0012 0.0012
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0553 0.1689 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0696 1
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0012 0.0002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus nmda type glutamate receptor 0.215 0.6614 0.6614
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) SRC-1 0.0045 0.0122 0.0113
Schistosoma mansoni tyrosine kinase 0.001 0.0014 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0109 0.0319 0.0319
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0012
Echinococcus multilocularis NCK adaptor protein 0.0009 0.001 0.001
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.1331 0.1331
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0109 0.0319 0.031
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0109 0.0319 0.0319
Echinococcus multilocularis microtubule associated protein 2 0.0738 0.2257 0.2257
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0122 0.0122
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0012 0.0012
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Onchocerca volvulus 0.0231 0.0696 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Echinococcus multilocularis fmrfamide receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.0112 0.0327 0.0318
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0012 0.0012
Schistosoma mansoni neuropeptide receptor 0.001 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0122 0.0122
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0122 0.0122
Echinococcus multilocularis growth factor receptor bound protein 2 0.0009 0.001 0.001
Schistosoma mansoni tyrosine kinase 0.0112 0.0327 0.0327
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0109 0.0319 0.0319
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0216 0.0648 0.0648
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0114 0.0333 0.0333
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0012 0.0012
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0012 0.0012
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0039 0.0039
Echinococcus granulosus growth factor receptor bound protein 2 0.0009 0.001 0.001
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0125 0.0125
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0122 0.0122
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0114 0.0333 0.0324
Onchocerca volvulus 0.0109 0.0319 0.4495
Schistosoma mansoni protein kinase 0.0112 0.0327 0.0327
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0112 0.0327 0.4613
Schistosoma mansoni histamine h1 receptor 0.001 0.0012 0.0012
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.079 0.2418 0.2418
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0216 0.0648 0.0648
Brugia malayi Dopamine receptor protein 1 0.001 0.0012 0.0002
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0111 0.0323 0.0323
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0111 0.0323 0.0314
Loa Loa (eye worm) glutamate receptor 2 0.0216 0.0648 0.0639
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni glutamate receptor kainate 0.0216 0.0648 0.0648
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0012 0.0012
Echinococcus multilocularis tyrosine kinase 0.0112 0.0327 0.0327
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0023 0.0013
Echinococcus multilocularis neuropeptide receptor 0.001 0.0012 0.0012
Echinococcus granulosus nmda type glutamate receptor 0.1492 0.4583 0.4583
Brugia malayi Dopamine receptor 0.001 0.0012 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0186 0.0186
Echinococcus multilocularis glutamate receptor 2 0.0327 0.0989 0.0989
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Brugia malayi Pre-SET motif family protein 0.003 0.0074 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0609 0.06
Trichomonas vaginalis pten, drome, putative 0.0109 0.0319 0.4561
Echinococcus granulosus microtubule associated protein 2 0.0738 0.2257 0.2257
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0109 0.0319 0.031
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus cpg binding protein 0.0032 0.0082 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis glutamate receptor NMDA 0.1381 0.4241 0.4241
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0012 0.0012
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0216 0.0648 0.0648
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0109 0.0319 0.9855
Entamoeba histolytica hypothetical protein 0.0111 0.0323 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0125 0.0125
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis sex peptide receptor 0.001 0.0012 0.0012
Schistosoma mansoni biogenic amine receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0216 0.0648 0.0648
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0553 0.1689 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Leishmania major tyrosine specific protein phosphatase, putative 0.0109 0.0319 0.9862
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0012 0.0002
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0122 0.0122
Echinococcus granulosus hypothetical protein 0.001 0.0012 0.0012
Schistosoma mansoni glutamate receptor NMDA 0.0216 0.0648 0.0648
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0111 0.0323 0.0314
Brugia malayi Doublecortin family protein 0.0042 0.0112 0.0102
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0014 0.0014
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0012 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus protein tyrosine phosphatase n9 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus g protein coupled receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0114 0.0333 0.0333
Schistosoma mansoni tyrosine kinase 0.0112 0.0327 0.0327
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0109 0.0319 0.9862
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0553 0.1689 0.5
Brugia malayi Protein-tyrosine phosphatase 0.0109 0.0319 0.031
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0125 0.0125
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0012 0.0012
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0109 0.0319 0.9855
Brugia malayi hypothetical protein 0.0109 0.0319 0.031
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0111 0.0323 0.0314
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0012 0.0012
Echinococcus granulosus glutamate NMDA receptor subunit 0.0216 0.0648 0.0648
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0012 0.0012
Brugia malayi Glutamate receptor 2 precursor 0.0216 0.0648 0.0639
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0333 0.0333
Echinococcus multilocularis 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0109 0.0109
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Schistosoma mansoni myosin xvIII 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0145 0.0136
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0012 0.0012
Echinococcus granulosus atrial natriuretic peptide receptor 0.0111 0.0323 0.0323
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0109 0.0319 0.9862
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0327 0.0318
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0111 0.0323 0.0323
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0109 0.0109
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus granulosus fmrfamide receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0327 0.0989 0.0989
Brugia malayi mbt repeat family protein 0.0046 0.0125 0.0116
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0012 0.0002
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0109 0.0319 0.0319
Brugia malayi Serotonin receptor 0.001 0.0012 0.0002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0109 0.0319 0.0319
Schistosoma mansoni ATP-binding cassette transporter 0.0216 0.0648 0.0648
Trypanosoma cruzi extracellular receptor, putative 0.0111 0.0323 1
Onchocerca volvulus 0.0109 0.0319 0.4495
Schistosoma mansoni ap endonuclease 0.0018 0.0039 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0014 0.0005
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0346 0.0346
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Brugia malayi Glutamate receptor 1 precursor 0.0216 0.0648 0.0639
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0012 0.0012
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0042 0.0112 0.0102
Brugia malayi putative neuropeptide receptor 0.001 0.0012 0.0002
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0109 0.0109
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0012 0.0012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0012 0.0002
Onchocerca volvulus 0.003 0.0074 0.0906
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0012 0.0002
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0109 0.0319 0.0319
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0109 0.0319 0.0319
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0012 0.0012
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0012 0.0012
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0109 0.0319 0.0319
Schistosoma mansoni protein tyrosine phosphatase 0.0109 0.0319 0.0319
Echinococcus multilocularis serotonin receptor 0.001 0.0012 0.0012
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0012 0.0012
Plasmodium vivax SET domain protein, putative 0.003 0.0074 0.4795
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis fmrfamide receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0112 0.0327 0.4613
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus tyrosine kinase 0.0112 0.0327 0.0327
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0001
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi larval opioid receptor 0.001 0.0012 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Schistosoma mansoni tyrosine kinase 0.0045 0.0122 0.0122
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0074 0.0074
Schistosoma mansoni glutamate receptor AMPA 0.0216 0.0648 0.0648
Schistosoma mansoni neuropeptide receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0327 0.0318
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0012 0.0002
Onchocerca volvulus 0.0109 0.0319 0.4495
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0012 0.0012
Echinococcus multilocularis neuropeptide receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Giardia lamblia Protein tyrosine phosphatase 0.0109 0.0319 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0012 0.0012
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0109 0.0319 0.0319
Schistosoma mansoni tyrosine kinase 0.0045 0.0122 0.0122
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni amine GPCR 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0109 0.0319 0.0319
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0012 0.0012
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0012 0.0012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Brugia malayi neuropeptide F receptor 0.001 0.0012 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0013 0.0023 0.0013
Schistosoma mansoni cpg binding protein 0.0032 0.0082 0.0082
Echinococcus granulosus serotonin receptor 0.001 0.0012 0.0012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0122 0.0122
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0109 0.0319 0.031
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0346 0.0346
Echinococcus granulosus g protein coupled receptor 0.001 0.0012 0.0012
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0109 0.0109
Onchocerca volvulus 0.0042 0.0112 0.1465
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0015 0.0005
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0012 0.0002
Echinococcus granulosus tyrosine kinase 0.0041 0.0109 0.0109
Schistosoma mansoni cpg binding protein 0.0031 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0074 0.0074
Brugia malayi Protein-tyrosine phosphatase 0.0109 0.0319 0.031
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0437 0.1331 0.1331
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0014 0.0014
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0012 0.0012
Schistosoma mansoni glutamate receptor kainate 0.0216 0.0648 0.0648
Onchocerca volvulus 0.0109 0.0319 0.4495
Schistosoma mansoni protein tyrosine phosphatase 0.0109 0.0319 0.0319
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Schistosoma mansoni biogenic amine receptor 0.001 0.0012 0.0012
Brugia malayi Guanylyl cyclase protein 23 0.0112 0.0327 0.0318
Echinococcus granulosus glutamate receptor NMDA 0.1381 0.4241 0.4241
Echinococcus granulosus somatostatin receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0042 0.0112 0.1465
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.0122 0.0122
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni opsin-like receptor 0.001 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Schistosoma mansoni rab6-interacting 0.0042 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0327 0.0989 0.0989
Schistosoma mansoni biogenic amine receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0012 0.0012
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0012 0.0012
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0012 0.0012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus multilocularis g protein coupled receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) TK protein kinase 0.0036 0.0095 0.0085
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus granulosus NCK adaptor protein 0.0009 0.001 0.001
Loa Loa (eye worm) CYP4Cod1 0.0013 0.0023 0.0013
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0125 0.0125
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0109 0.0319 0.0319
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0109 0.0319 0.0319
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni glutamate receptor kainate 0.0216 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0145 0.0145
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0039 0.053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Schistosoma mansoni loxhd1 0.0042 0.0112 0.0112
Schistosoma mansoni tyrosine kinase 0.001 0.0014 0.0014
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0125 0.0125
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0012 0.0012
Brugia malayi follicle stimulating hormone receptor 0.001 0.0012 0.0002
Schistosoma mansoni opsin-like receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0111 0.0323 0.4555
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0105 0.0105
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0039 0.0506
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni hypothetical protein 0.0042 0.0112 0.0112
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0012 0.0012
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0109 0.0319 0.0319
Onchocerca volvulus 0.0109 0.0319 0.4495
Loa Loa (eye worm) doublecortin family protein 0.0042 0.0112 0.0102
Echinococcus granulosus orexin receptor type 2 0.001 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Brugia malayi G-protein coupled receptor 0.001 0.0012 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0105 0.0105
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0012 0.0002
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0125 0.0116
Schistosoma mansoni nck2/grb4 0.0009 0.001 0.001
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.0112 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0012 0.0002
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0109 0.0319 0.0319
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0012 0.0012
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0109 0.0319 0.0319
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0122 0.0122
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni amine GPCR 0.001 0.0012 0.0012
Brugia malayi hypothetical protein 0.0109 0.0319 0.031
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0012 0.0012
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0012 0.0012
Chlamydia trachomatis glutamine binding protein 0.0553 0.1689 0.5
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0012 0.0012
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0122 0.0122
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0014 0.0014
Schistosoma mansoni neuropeptide receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0012 0.0002
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0068 0.0068
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0111 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0046 0.0125 0.0116
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0327 0.0989 0.0989
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0216 0.0648 0.0648
Schistosoma mansoni metabotropic glutamate receptor 0.0111 0.0323 0.0323
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.3248 1 1
Echinococcus multilocularis somatostatin receptor 0.001 0.0012 0.0012
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Brugia malayi hypothetical protein 0.0109 0.0319 0.031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0109 0.0319 0.0319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Brugia malayi hypothetical protein 0.0042 0.0112 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni rab6-interacting 0.0042 0.0112 0.0112
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0012 0.0002
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0012 0.0012
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0145 0.0145
Brugia malayi Receptor family ligand binding region containing protein 0.0111 0.0323 0.0314
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.001 0.001
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0012 0.0002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0012 0.0012
Brugia malayi Dopamine receptor protein 2 0.001 0.0012 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0012 0.0012
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0216 0.0648 0.0648
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0109 0.0319 0.0319
Schistosoma mansoni metabotropic glutamate receptor 0.0111 0.0323 0.0323
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0122 0.0122
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0012 0.0012
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0012 0.0002
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0145 0.0136
Echinococcus multilocularis cpg binding protein 0.0032 0.0082 0.0082
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Brugia malayi hypothetical protein 0.0111 0.0323 0.0314
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi Metabotropic glutamate receptor precursor. 0.0111 0.0323 0.0314
Brugia malayi CXXC zinc finger family protein 0.0031 0.0077 0.0067
Onchocerca volvulus 0.0109 0.0319 0.4495
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0012 0.0012
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0553 0.1689 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Trypanosoma brucei protein tyrosine phosphatase 1 0.0109 0.0319 1
Schistosoma mansoni polycystin 1-related 0.0042 0.0112 0.0112
Echinococcus granulosus neuropeptide receptor 0.001 0.0012 0.0012
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Brugia malayi GnHR receptor homolog 0.001 0.0012 0.0002
Schistosoma mansoni hypothetical protein 0.0286 0.0865 0.0865
Brugia malayi RE15519p 0.001 0.0012 0.0002
Echinococcus granulosus g protein coupled receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Onchocerca volvulus 0.0109 0.0319 0.4495
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0165 1
Leishmania major extracellular receptor, putative 0.0111 0.0323 1
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0009
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0109 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0122 0.0122
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0109 0.0319 0.9862
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Brugia malayi hypothetical protein 0.0042 0.0112 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0125 0.0125
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Echinococcus multilocularis nmda type glutamate receptor 0.1492 0.4583 0.4583
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Brugia malayi Cytochrome P450 family protein 0.0013 0.0023 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0012 0.0002
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0012 0.0012
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0109 0.0319 0.9862
Schistosoma mansoni glutamate receptor NMDA 0.1708 0.5249 0.5249
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni adenoreceptor 0.001 0.0012 0.0012
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0109 0.0319 0.9855
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0074 0.0074
Brugia malayi Pre-SET motif family protein 0.0203 0.0609 0.06
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0145 0.0145
Echinococcus granulosus metabotropic glutamate receptor 2 0.0111 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis RUN 0.0042 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) RGC/RGC protein kinase 0.0112 0.0327 0.0318
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0074 0.0074
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0122 0.0122
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis nmda type glutamate receptor 0.215 0.6614 0.6614
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0109 0.0109
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0012 0.0002
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0122 0.0122
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis allatostatin A receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Echinococcus granulosus glutamate receptor 2 0.0327 0.0989 0.0989
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0031 0.0077 0.0949
Schistosoma mansoni glutamate receptor AMPA 0.0216 0.0648 0.0648
Brugia malayi hypothetical protein 0.0109 0.0319 0.031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0039 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0558 0.0558
Echinococcus granulosus tyrosine protein kinase HCK 0.0036 0.0095 0.0095
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0109 0.0319 0.0319
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Loa Loa (eye worm) glutamate receptor 1 0.0216 0.0648 0.0639
Echinococcus multilocularis hypothetical protein 0.0109 0.0319 0.0319
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0012 0.0012
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0009 0.0009
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0114 0.0333 0.0333
Echinococcus multilocularis glutamate receptor 2 0.0111 0.0323 0.0323
Echinococcus multilocularis NMDA receptor 0.0216 0.0648 0.0648
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0558 0.0558
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0012 0.0012
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0039 0.0029
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0109 0.0319 0.0319
Brugia malayi neuropeptide F receptor 0.001 0.0012 0.0002
Onchocerca volvulus 0.0046 0.0125 0.166
Brugia malayi Melatonin receptor type 1A 0.001 0.0012 0.0002
Schistosoma mansoni lipoxygenase 0.0118 0.0346 0.0346
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.0112 0.0112
Schistosoma mansoni protein tyrosine phosphatase 0.0109 0.0319 0.0319
Echinococcus granulosus neuropeptide receptor 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0109 0.0319 0.0319
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.0112 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0109 0.0319 0.0319
Echinococcus multilocularis g protein coupled receptor 0.001 0.0012 0.0012
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0009 0.0009
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Echinococcus multilocularis tyrosine protein kinase HCK 0.0036 0.0095 0.0095
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0109 0.0319 0.0319
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0012 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0111 0.0323 0.0314
Echinococcus multilocularis orexin receptor type 2 0.001 0.0012 0.0012
Schistosoma mansoni microtubule-associated protein tau 0.0738 0.2257 0.2257
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0327 0.0989 0.0989
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Brugia malayi metabotropic glutamate receptor type 2 0.0111 0.0323 0.0314
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0109 0.0319 0.0319
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Onchocerca volvulus 4.1 G protein, putative homolog 0.0109 0.0319 0.4495
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0012 0.0012
Onchocerca volvulus 0.0109 0.0319 0.4495
Loa Loa (eye worm) protein tyrosine phosphatase 0.0109 0.0319 0.031
Onchocerca volvulus 0.0109 0.0319 0.4495
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0039 0.0096
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0012 0.0012
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0109 0.0319 0.0319
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.0112 0.0112
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.3248 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0145 0.0145
Brugia malayi AKH receptor 0.001 0.0012 0.0002
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.3248 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0109 0.0319 0.031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0009 0.0009
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0012 0.0012
Brugia malayi hypothetical protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0012 0.0012
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.0112 0.0112
Brugia malayi hypothetical protein 0.001 0.0012 0.0002
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0327 0.0989 0.0989
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0109 0.0319 0.031
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0009 0.0009
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0553 0.1689 1
Echinococcus granulosus c src tyrosine kinase 0.001 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0109 0.0319 0.031
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0109 0.0319 0.0319
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0002
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0012 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.8 uM Inhibition of c-Src tyrosine kinase against 100 uM cdc2 substrate ChEMBL. 9632358
IC50 (binding) = 1.8 uM Inhibition of c-Src tyrosine kinase against 100 uM cdc2 substrate ChEMBL. 9632358
IC50 (binding) = 260 uM Inhibition of p56 Lck kinase against 100 uM cdc2 substrate ChEMBL. 9632358
IC50 (binding) = 260 uM Inhibition of p56 Lck kinase against 100 uM cdc2 substrate ChEMBL. 9632358
IC50 (binding) > 800 uM Inhibition of Lyn kinase against 100 uM cdc2 substrate ChEMBL. 9632358
IC50 (binding) > 800 uM Inhibition of Lyn kinase against 100 uM cdc2 substrate ChEMBL. 9632358
Selectivity (binding) = 170 Selectivity for Src over Lck kinase ChEMBL. 9632358
Selectivity (binding) > 530 Selectivity for Src over Lyn kinase ChEMBL. 9632358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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