Detailed information for compound 401415

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 998.202 | Formula: C46H71N13O10S
  • H donors: 11 H acceptors: 11 LogP: -1.5 Rotable bonds: 32
    Rule of 5 violations (Lipinski): 4
  • SMILES: CNCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1CSC(C1C(=O)N[C@H](C(=O)N1CCC[C@@H]1C(=O)N[C@H]([C@H](CC)C)C(=O)O)Cc1c[nH]cn1)(C)C)Cc1ccc(cc1)O)C(C)C)CCCN=C(N)N
  • InChi: 1S/C46H71N13O10S/c1-8-26(4)36(44(68)69)57-39(63)33-12-10-18-58(33)42(66)32(20-28-21-50-23-52-28)55-41(65)37-46(5,6)70-24-59(37)43(67)31(19-27-13-15-29(60)16-14-27)54-40(64)35(25(2)3)56-38(62)30(53-34(61)22-49-7)11-9-17-51-45(47)48/h13-16,21,23,25-26,30-33,35-37,49,60H,8-12,17-20,22,24H2,1-7H3,(H,50,52)(H,53,61)(H,54,64)(H,55,65)(H,56,62)(H,57,63)(H,68,69)(H4,47,48,51)/t26-,30-,31-,32-,33-,35-,36-,37?/m0/s1
  • InChiKey: LTQDQCLZIXJVML-RQITUHHYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0071 0.008 0.0068
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0075 0.0088 0.1235
Trypanosoma cruzi metacaspase 5, putative 0.0115 0.0152 0.0432
Schistosoma mansoni voltage-gated cation channel 0.0071 0.008 0.0222
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0081 0.0097 0.0277
Echinococcus granulosus sodium:glucose cotransporter 0.0041 0.0031 0.0019
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.2154 0.3526 1
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.0357 0.1013
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0097 0.0276
Echinococcus multilocularis sodium leak channel non selective protein 0.0071 0.008 0.0068
Brugia malayi Zinc knuckle family protein 0.0035 0.002 0.0057
Onchocerca volvulus 0.0075 0.0088 0.3704
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0071 0.008 0.0068
Echinococcus granulosus transient receptor potential cation channel 0.0071 0.008 0.0068
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0199 0.0292 0.0827
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0146 0.0204 0.0193
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0115 0.0152 0.0451
Echinococcus granulosus voltage dependent calcium channel 0.0071 0.008 0.0068
Leishmania major phosphatidylinositol kinase related protein, putative 0.0081 0.0097 0.027
Brugia malayi Transient-receptor-potential like protein 0.0071 0.008 0.0226
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.021 0.0198
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0081 0.0097 0.0085
Entamoeba histolytica CAAX prenyl protease family 0.0199 0.0292 0.4134
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0238 0.0357 0.5171
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Loa Loa (eye worm) voltage-dependent calcium channel 0.0071 0.008 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.2154 0.3526 0.9772
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0075 0.0088 0.0248
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Loa Loa (eye worm) hypothetical protein 0.0156 0.022 0.0625
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0238 0.0357 0.0345
Loa Loa (eye worm) hypothetical protein 0.1733 0.2828 0.8022
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0071 0.008 0.0068
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.0088 0.0248
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0199 0.0292 0.089
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0071 0.008 0.0222
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0049 0.014
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0035 0.002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0075 0.0088 0.0248
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0097 0.0276
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.008 0.1115
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0071 0.008 0.0226
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0081 0.0097 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0152 0.206
Giardia lamblia Phosphatidylinositol 4-kinase 0.0081 0.0097 0.1202
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Echinococcus multilocularis voltage dependent calcium channel 0.0071 0.008 0.0068
Echinococcus multilocularis voltage gated potassium channel 0.0146 0.0204 0.0193
Schistosoma mansoni caspase-3 (C14 family) 0.026 0.0392 0.1207
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0071 0.008 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Echinococcus multilocularis potassium voltage gated channel protein 0.1733 0.2828 0.282
Trypanosoma brucei ribonuclease H1 0.0153 0.0216 0.0613
Treponema pallidum ribonuclease H (rnhA) 0.0153 0.0216 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0071 0.008 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0081 0.0097 0.0276
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0115 0.0152 0.0432
Echinococcus multilocularis caspase 8 0.0115 0.0152 0.014
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0071 0.008 0.0222
Schistosoma mansoni cpg binding protein 0.003 0.0012 0.0008
Trypanosoma brucei unspecified product 0.0188 0.0274 0.0776
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Trypanosoma cruzi hypothetical protein 0.0066 0.0072 0.0205
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0081 0.0097 0.1202
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0075 0.0088 0.0248
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Trypanosoma brucei RNA helicase, putative 0.1946 0.3181 0.9021
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0071 0.008 0.0222
Echinococcus multilocularis two pore calcium channel protein 2 0.0071 0.008 0.0068
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0423 0.0662 0.1835
Echinococcus granulosus apoptotic protease activating factor 1 0.0041 0.0031 0.0019
Schistosoma mansoni kinase 0.0062 0.0066 0.0177
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0071 0.008 0.0226
Trypanosoma brucei metacaspase 0.0115 0.0152 0.0432
Onchocerca volvulus 0.0041 0.0031 0.1009
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.6069 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0097 0.0277
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0146 0.0204 0.0193
Onchocerca volvulus 0.0075 0.0088 0.3704
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0063 0.0674
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0081 0.0097 0.1202
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0035 0.002 0.0008
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0081 0.0097 0.1202
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0071 0.008 0.0226
Echinococcus granulosus serine protein kinase ATM 0.0238 0.0357 0.0345
Echinococcus granulosus mitogen activated protein kinase 11 0.2154 0.3526 0.3518
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0048 0.0135
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0097 0.0276
Mycobacterium ulcerans hypothetical protein 0.0041 0.0031 1
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.017 0.0483
Schistosoma mansoni caspase-7 (C14 family) 0.026 0.0392 0.1207
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0071 0.008 0.0226
Mycobacterium ulcerans hypothetical protein 0.0041 0.0031 1
Onchocerca volvulus 0.0075 0.0088 0.3704
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0266 0.0402 0.1141
Echinococcus granulosus sodium leak channel non selective protein 0.0071 0.008 0.0068
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0071 0.008 0.3332
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0081 0.0097 0.0085
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0149 0.0422
Leishmania major hypothetical protein, unknown function 0.0071 0.008 0.0221
Trichomonas vaginalis ribonuclease H1, putative 0.0153 0.0216 0.3053
Trypanosoma cruzi target of rapamycin kinase 3 0.0423 0.0662 0.1878
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0035 0.002 0.0057
Echinococcus multilocularis hyperpolarization activated cyclic 0.0071 0.008 0.0068
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.1056
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0049 0.014
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0081 0.0097 0.6221
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Loa Loa (eye worm) hypothetical protein 0.0376 0.0584 0.1658
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Brugia malayi ion channel NompC 0.0071 0.008 0.0226
Echinococcus granulosus sodium channel protein 0.0152 0.0214 0.0202
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0088 0.0246
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0071 0.008 0.0068
Onchocerca volvulus 0.0081 0.0097 0.4167
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0097 0.0277
Loa Loa (eye worm) hypothetical protein 0.0146 0.0204 0.058
Brugia malayi reverse transcriptase 0.0035 0.002 0.0057
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0081 0.0097 0.0276
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0097 0.1384
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus granulosus transient receptor potential cation channel 0.0071 0.008 0.0068
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0041 0.0031 0.0019
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Schistosoma mansoni caspase-7 (C14 family) 0.0156 0.022 0.0665
Echinococcus granulosus BTB:POZ domain containing protein 0.0075 0.0088 0.0076
Echinococcus multilocularis ribonuclease H1 0.0153 0.0216 0.0204
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0066 0.0072 0.0812
Loa Loa (eye worm) hypothetical protein 0.0036 0.0022 0.0063
Echinococcus multilocularis potassium voltage gated channel protein 0.0146 0.0204 0.0193
Onchocerca volvulus Ribonuclease H1 homolog 0.0153 0.0216 0.9801
Schistosoma mansoni hypothetical protein 0.0081 0.0097 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0071 0.008 0.0068
Leishmania major hypothetical protein, unknown function 0.0081 0.0097 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0402 0.5952
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0071 0.008 0.0222
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Echinococcus granulosus c-Jun N-terminal kinases 0.1217 0.1976 0.1966
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0088 0.0246
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0081 0.0097 0.0277
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.0088 0.0248
Echinococcus multilocularis BTB:POZ domain containing protein 0.0075 0.0088 0.0076
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0097 0.0276
Brugia malayi serine/threonine-protein kinase plk-2 0.0112 0.0149 0.0422
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0071 0.008 0.0222
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0204 0.0615
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0112 0.0149 0.0137
Schistosoma mansoni 60S ribosomal protein L21 0.0071 0.008 0.0222
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0152 0.2224
Brugia malayi hypothetical protein 0.0027 0.0007 0.0019
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0035 0.002 0.0008
Echinococcus granulosus TRP transient receptor potential channel 0.0071 0.008 0.0068
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0071 0.008 0.0068
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0071 0.008 0.0068
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Brugia malayi FAT domain containing protein 0.0184 0.0268 0.0759
Toxoplasma gondii transporter, cation channel family protein 0.0071 0.008 0.1115
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0071 0.008 0.0226
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0423 0.0662 0.1878
Plasmodium falciparum kelch protein K13 0.0075 0.0088 0.5551
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0097 0.0085
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0146 0.0204 0.0193
Giardia lamblia Hypothetical protein 0.0081 0.0097 0.1202
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0081 0.0097 0.0276
Entamoeba histolytica serine/threonine protein kinase, putative 0.0112 0.0149 0.187
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0035 0.002 0.0008
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.1202
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0081 0.0097 0.0085
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0038 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Loa Loa (eye worm) calcium channel 0.0071 0.008 0.0226
Trypanosoma cruzi metacaspase 5, putative 0.0115 0.0152 0.0432
Echinococcus multilocularis tumor protein p63 0.0332 0.0512 0.05
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0423 0.0662 0.1878
Leishmania major potassium voltage-gated channel, putative 0.0075 0.0088 0.0243
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Echinococcus multilocularis shaker cognate 0.0146 0.0204 0.0193
Schistosoma mansoni voltage-gated potassium channel 0.1733 0.2828 0.8889
Loa Loa (eye worm) hypothetical protein 0.0199 0.0292 0.0827
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0097 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0149 0.021 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0343 0.053 0.7981
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.1217 0.1976 0.5605
Onchocerca volvulus 0.0049 0.0043 0.1597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0035 0.002 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0223 0.3154
Trichomonas vaginalis CAMK family protein kinase 0.0061 0.0063 0.0674
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0097 0.0276
Echinococcus multilocularis caspase 0.026 0.0392 0.0381
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0035 0.002 0.0008
Trypanosoma brucei ingi protein (ORF1) 0.0188 0.0274 0.0776
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0081 0.0097 0.0276
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0146 0.0204 0.0193
Toxoplasma gondii CAAX amino terminal protease family protein 0.0041 0.0031 0.0367
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0199 0.0292 0.089
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0071 0.008 0.0222
Schistosoma mansoni hypothetical protein 0.1946 0.3181 1
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0071 0.008 0.3332
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0071 0.008 0.0068
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0238 0.0357 0.1013
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0097 0.0276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0097 0.0276
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.6221
Schistosoma mansoni high-affinity choline transporter 0.0376 0.0584 0.1813
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0007 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0097 0.0276
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.026 0.0392 0.0381
Schistosoma mansoni vesicular amine transporter 0.0146 0.0204 0.0615
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0071 0.008 0.0222
Echinococcus granulosus caspase 2 0.0156 0.022 0.0209
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0204 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0035 0.002 0.0034
Echinococcus multilocularis voltage gated potassium channel 0.0071 0.008 0.0068
Plasmodium falciparum metacaspase 1 0.0115 0.0152 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0097 0.1384
Echinococcus multilocularis transfer RNA-Gly 0.0146 0.0204 0.0193
Trypanosoma cruzi hypothetical protein, conserved 0.2123 0.3473 0.9851
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0081 0.0097 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0266 0.0402 0.5952
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0041 0.0031 0.1359
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0423 0.0662 0.0651
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Trypanosoma cruzi metacaspase, putative 0.0115 0.0152 0.0432
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0087
Trypanosoma cruzi potassium voltage-gated channel 0.0075 0.0088 0.0248
Schistosoma mansoni phosphoglucomutase 0.0153 0.0216 0.0652
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.1056
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0097 0.6221
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0112 0.0149 0.0422
Schistosoma mansoni phosphoglucomutase 0.0153 0.0216 0.0652
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0423 0.0662 0.1835
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0423 0.0662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus transient receptor potential cation channel 0.0071 0.008 0.0068
Echinococcus multilocularis 0.0081 0.0097 0.0085
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0071 0.008 0.0222
Echinococcus multilocularis mitogen activated protein kinase 14 0.2154 0.3526 0.3518
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0081 0.0097 0.0085
Echinococcus multilocularis caspase 3 0.0145 0.0203 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Loa Loa (eye worm) Ulp1 protease 0.0066 0.0072 0.0205
Echinococcus multilocularis ryanodine receptor 44f 0.0071 0.008 0.0068
Echinococcus multilocularis hyperpolarization activated cyclic 0.0071 0.008 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0097 0.1202
Echinococcus multilocularis calcium activated potassium channel 0.0081 0.0097 0.0085
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0204 0.0193
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0238 0.0357 0.1097
Mycobacterium tuberculosis Probable integral membrane protein 0.0041 0.0031 0.1359
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0184 0.0268 0.0256
Echinococcus multilocularis transient receptor potential cation channel 0.0071 0.008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0115 0.0152 0.0432
Chlamydia trachomatis hypothetical protein 0.0041 0.0031 0.5
Trypanosoma brucei Metacaspase-4 0.0115 0.0152 0.0432
Trypanosoma cruzi metacaspase, putative 0.0115 0.0152 0.0432
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0097 0.1384
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0081 0.0097 0.0085
Trypanosoma brucei metacaspase 5, putative 0.0115 0.0152 0.0432
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0007 0.0019
Echinococcus multilocularis transient receptor potential cation channel 0.0071 0.008 0.0068
Echinococcus granulosus traf and tnf receptor associated protein 0.0353 0.0547 0.0535
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0097 0.1384
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0071 0.008 0.0068
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0423 0.0662 0.1878
Entamoeba histolytica hypothetical protein 0.0238 0.0357 0.5171
Plasmodium vivax protease, putative 0.0041 0.0031 0.1649
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0075 0.0088 0.5551
Toxoplasma gondii hypothetical protein 0.0041 0.0031 0.0367
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0071 0.008 0.0068
Entamoeba histolytica hypothetical protein 0.0081 0.0097 0.1056
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0423 0.0662 0.1878
Schistosoma mansoni hypothetical protein 0.0041 0.0031 0.0067
Toxoplasma gondii hypothetical protein 0.0071 0.008 0.1115
Toxoplasma gondii target of rapamycin (TOR), putative 0.0423 0.0662 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0152 0.206
Toxoplasma gondii hypothetical protein 0.0071 0.008 0.1115
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0041 0.0031 0.0019
Brugia malayi RNase H family protein 0.0153 0.0216 0.0613
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.008 0.0928
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0071 0.008 0.0068
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0075 0.0088 0.0248
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0066 0.0072 0.0812
Brugia malayi Stress-activated protein kinase jnk-1 0.1217 0.1976 0.5605
Brugia malayi hypothetical protein 0.0071 0.008 0.0226
Brugia malayi P38 map kinase family protein 2 0.2154 0.3526 1
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0075 0.0088 0.0248
Schistosoma mansoni edp1-related 0.0075 0.0088 0.0246
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0152 0.206
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Trypanosoma brucei potassium voltage-gated channel, putative 0.0075 0.0088 0.0248
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0097 0.1202
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0097 0.1202
Brugia malayi reverse transcriptase 0.0035 0.002 0.0057
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0204 0.0615
Loa Loa (eye worm) hypothetical protein 0.0081 0.0097 0.0276
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0081 0.0097 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0097 0.6221
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0097 0.0276
Echinococcus granulosus potassium large conductance calcium activated 0.0071 0.008 0.0068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0097 0.0276
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0157 0.0223 0.0631
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0075 0.0088 0.0248
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.2154 0.3526 1
Brugia malayi reverse transcriptase 0.0035 0.002 0.0057
Echinococcus multilocularis transient receptor potential cation channel 0.0071 0.008 0.0068
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.0276
Trichomonas vaginalis Sentrin-specific protease, putative 0.0066 0.0072 0.0812
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0097 0.1202
Leishmania major hypothetical protein, conserved 0.0075 0.0088 0.0243
Echinococcus granulosus two pore calcium channel protein 1 0.0071 0.008 0.0068
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Onchocerca volvulus 0.0035 0.002 0.0511
Onchocerca volvulus 0.0071 0.008 0.3332
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0071 0.008 0.0928
Echinococcus granulosus calcium activated potassium channel 0.0081 0.0097 0.0085
Echinococcus multilocularis potassium voltage gated channel protein 0.0146 0.0204 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.021 0.0631
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0071 0.008 0.0226
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0081 0.0097 0.1056
Brugia malayi CXXC zinc finger family protein 0.0028 0.0009 0.0027
Echinococcus granulosus potassium voltage gated channel protein 0.0146 0.0204 0.0193
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0071 0.008 0.0226
Trypanosoma brucei polo-like protein kinase 0.0112 0.0149 0.0422
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0081 0.0097 0.0085
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Plasmodium falciparum protease, putative 0.0041 0.0031 0.1649
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.0088 0.0248
Echinococcus granulosus voltage dependent calcium channel 0.0071 0.008 0.0068
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.1056
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0081 0.0097 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0423 0.0662 0.0651
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0071 0.008 0.0222
Echinococcus multilocularis mitogen activated protein kinase 11 0.2154 0.3526 0.3518
Echinococcus multilocularis traf and tnf receptor associated protein 0.0353 0.0547 0.0535
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0009 0.0027
Brugia malayi Cytochrome P450 family protein 0.0051 0.0048 0.0135
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Schistosoma mansoni inositol transporter 0.0041 0.0031 0.0069
Leishmania major hypothetical protein, conserved 0.0075 0.0088 0.0243
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0238 0.0357 0.1013
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0152 0.206
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0423 0.0662 0.1878
Onchocerca volvulus 0.0081 0.0097 0.4167
Loa Loa (eye worm) hypothetical protein 0.0075 0.0088 0.0248
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Schistosoma mansoni transient receptor potential channel 4 0.0071 0.008 0.0222
Echinococcus granulosus mitogen activated protein kinase 14 0.2154 0.3526 0.3518
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0081 0.0097 0.0276
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0071 0.008 0.0222
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Plasmodium falciparum metacaspase-like protein 0.0115 0.0152 1
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0071 0.008 0.0226
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0066 0.0072 0.0198
Loa Loa (eye worm) phosphatidylinositol 3 0.0423 0.0662 0.1878
Echinococcus multilocularis potassium large conductance calcium activated 0.0071 0.008 0.0068
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0152 0.2224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0157 0.0223 0.3154
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0423 0.0662 1
Echinococcus multilocularis transient receptor potential cation channel 0.0071 0.008 0.0068
Echinococcus multilocularis two pore calcium channel protein 1 0.0071 0.008 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.002 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0423 0.0662 0.0651
Echinococcus multilocularis sodium channel protein 0.0152 0.0214 0.0202
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Brugia malayi follicle stimulating hormone receptor 0.0236 0.0353 0.1
Trichomonas vaginalis conserved hypothetical protein 0.0184 0.0268 0.3856
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0238 0.0357 0.1013
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.1056
Schistosoma mansoni calcium-activated potassium channel 0.0071 0.008 0.0222
Loa Loa (eye worm) hypothetical protein 0.0184 0.0268 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Schistosoma mansoni cpg binding protein 0.003 0.0012 0.0008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0049 0.014
Trypanosoma brucei metacaspase MCA3 0.0115 0.0152 0.0432
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.0662 0.1878
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0115 0.0152 0.2224
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Echinococcus granulosus transient receptor potential cation channel 0.0071 0.008 0.0068
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0071 0.008 0.1115
Loa Loa (eye worm) ryanodine receptor 0.0071 0.008 0.0226
Echinococcus granulosus potassium voltage gated channel protein 0.1733 0.2828 0.282
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.1056
Giardia lamblia Hypothetical protein 0.0199 0.0292 0.423
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0152 0.0214 0.0592
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Echinococcus granulosus hyperpolarization activated cyclic 0.0071 0.008 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0204 0.0615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0031 0.1359
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0199 0.0292 0.423
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0071 0.008 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.021 0.0198
Echinococcus multilocularis apoptotic protease activating factor 1 0.0041 0.0031 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0152 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0423 0.0662 0.1835
Echinococcus granulosus hyperpolarization activated cyclic 0.0071 0.008 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus CAAX prenyl protease 2 0.0199 0.0292 0.028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Giardia lamblia GTOR 0.0423 0.0662 1
Echinococcus multilocularis transient receptor potential cation channel 0.0071 0.008 0.0068
Echinococcus granulosus transient receptor potential cation channel 0.0071 0.008 0.0068
Echinococcus multilocularis transient receptor potential cation channel 0.0071 0.008 0.0068
Toxoplasma gondii transporter, cation channel family protein 0.0071 0.008 0.1115
Echinococcus granulosus voltage gated potassium channel 0.0071 0.008 0.0068
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.1657 0.2703 0.2695
Schistosoma mansoni hypothetical protein 0.0035 0.002 0.0034
Echinococcus multilocularis transient receptor potential gamma protein 0.0071 0.008 0.0068
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0423 0.0662 0.1878
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0041 0.0031 0.1359
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0071 0.008 0.0226
Echinococcus multilocularis Zinc finger, PHD finger 0.0081 0.0097 0.0085
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0075 0.0088 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0238 0.0357 0.1013
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.008 0.0068
Plasmodium vivax hypothetical protein 0.0081 0.0097 0.6221
Loa Loa (eye worm) phosphatidylinositol 3 0.0423 0.0662 0.1878
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0146 0.0204 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0152 0.206
Brugia malayi mKIAA0176 protein 0.0075 0.0088 0.0248
Brugia malayi hypothetical protein 0.0041 0.0031 0.0087
Brugia malayi hypothetical protein 0.0035 0.002 0.0057
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0071 0.008 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0007 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0071 0.008 0.0222
Loa Loa (eye worm) hypothetical protein 0.0081 0.0097 0.0276
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0041 0.0031 0.0377
Echinococcus granulosus shaker cognate 0.0146 0.0204 0.0193
Schistosoma mansoni sodium/solute symporter 0.0041 0.0031 0.0069
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Echinococcus granulosus sodium:glucose cotransporter 2 0.0041 0.0031 0.0019
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.0097 0.1202
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0204 0.0615
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0097 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.0152 0.206
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0071 0.008 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.021 0.0631
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0184 0.0268 0.0256
Echinococcus multilocularis c Jun NH2 terminal kinase 0.1217 0.1976 0.1966
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0071 0.008 0.0222
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0097 0.1202
Echinococcus multilocularis CAAX prenyl protease 2 0.0199 0.0292 0.028
Brugia malayi CAAX amino terminal protease family protein 0.0199 0.0292 0.0827
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0071 0.008 0.0068
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Toxoplasma gondii ribonuclease HI protein 0.0153 0.0216 0.3197
Trypanosoma cruzi metacaspase, putative 0.0115 0.0152 0.0432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0149 0.021 0.0198
Onchocerca volvulus 0.0035 0.002 0.051
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus voltage gated potassium channel 0.0146 0.0204 0.0193
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0423 0.0662 0.1878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0149 0.021 0.0631
Leishmania major hypothetical protein, conserved 0.0075 0.0088 0.0243
Schistosoma mansoni hypothetical protein 0.0035 0.002 0.0034
Echinococcus multilocularis mitogen activated protein kinase 14 0.2154 0.3526 0.3518
Brugia malayi cation channel family protein 0.0071 0.008 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0075 0.0088 0.0246
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0071 0.008 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0041 0.0031 0.0019
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0071 0.008 0.0068
Echinococcus granulosus caspase 0.026 0.0392 0.0381
Giardia lamblia Ribonuclease H 0.0153 0.0216 0.3053
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.0627 0.0616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0112 0.0149 0.6606
Leishmania major phosphatidylinositol kinase, putative 0.0081 0.0097 0.027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0019
Schistosoma mansoni hypothetical protein 0.0071 0.008 0.0222
Echinococcus granulosus potassium voltage gated channel subfamily A 0.1733 0.2828 0.282
Schistosoma mansoni voltage-dependent calcium channel 0.0071 0.008 0.0222
Brugia malayi Sodium:solute symporter family protein 0.0041 0.0031 0.0089
Brugia malayi RNase H family protein 0.0153 0.0216 0.0613
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0071 0.008 0.0226
Leishmania major ribonuclease H1, putative 0.0153 0.0216 0.0599
Leishmania major phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.027
Echinococcus granulosus KRAB A domain containing protein 0.0035 0.002 0.0008
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0097 0.1202
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.0353 0.1
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Brugia malayi voltage-dependent calcium channel 0.0071 0.008 0.0226
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.0276
Entamoeba histolytica hypothetical protein 0.0081 0.0097 0.1056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0238 0.0357 0.0345
Schistosoma mansoni two-pore calcium channel 0.0071 0.008 0.0222
Echinococcus granulosus caspase 8 0.0115 0.0152 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Loa Loa (eye worm) voltage-gated potassium channel 0.0146 0.0204 0.058
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0423 0.0662 0.1835
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Schistosoma mansoni transient receptor potential channel 0.0071 0.008 0.0222
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0075 0.0088 0.0248
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0066 0.0072 0.0205
Schistosoma mansoni protein kinase 0.0035 0.002 0.0034
Loa Loa (eye worm) hypothetical protein 0.0157 0.0223 0.0631
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0071 0.008 0.0068
Brugia malayi hypothetical protein 0.0035 0.002 0.0057
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Brugia malayi Cyclic-nucleotide gated cation channel 0.0071 0.008 0.0226
Brugia malayi olfactory channel protein osm-9 0.0071 0.008 0.0226
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0071 0.008 0.0068
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0081 0.0097 0.1384
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0071 0.008 0.0068
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0081 0.0097 0.1056
Schistosoma mansoni ryanodine receptor related 0.0071 0.008 0.0222
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0081 0.0097 0.1202
Echinococcus multilocularis high affinity choline transporter 1 0.0376 0.0584 0.0573
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0081 0.0097 0.1202
Trypanosoma brucei btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0089
Schistosoma mansoni fkbp-rapamycin associated protein 0.0238 0.0357 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0097 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0097 0.1202
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0075 0.0088 0.5551
Entamoeba histolytica protein kinase rad3, putative 0.0238 0.0357 0.5171
Schistosoma mansoni transient receptor potential channel 0.0071 0.008 0.0222
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.0276
Brugia malayi Zinc knuckle family protein 0.0035 0.002 0.0057
Echinococcus multilocularis voltage dependent calcium channel 0.0071 0.008 0.0068
Onchocerca volvulus 0.0075 0.0088 0.3704
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0071 0.008 0.0226
Loa Loa (eye worm) hypothetical protein 0.0075 0.0088 0.0248
Schistosoma mansoni voltage-gated potassium channel 0.0146 0.0204 0.0615
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0112 0.0149 0.0137
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0071 0.008 0.0226
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0353 0.0547 0.1551
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0097 0.0085
Echinococcus granulosus two pore calcium channel protein 2 0.0071 0.008 0.0068
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0423 0.0662 0.1878
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0043 0.0106
Brugia malayi K+ channel tetramerisation domain containing protein 0.0075 0.0088 0.0248
Mycobacterium tuberculosis Conserved hypothetical protein 0.0081 0.0097 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0423 0.0662 0.1878
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0149 0.0439
Loa Loa (eye worm) voltage-gated calcium channel 0.0071 0.008 0.0226
Schistosoma mansoni hypothetical protein 0.0402 0.0627 0.1948
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0097 0.6221
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0071 0.008 0.0226
Entamoeba histolytica hypothetical protein 0.0081 0.0097 0.1056
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0041 0.0031 0.0019
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0066 0.0072 0.0659
Echinococcus granulosus ryanodine receptor 44f 0.0071 0.008 0.0068
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0075 0.0088 0.0246
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0062 0.0165
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0097 0.0276
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0097 0.1202
Brugia malayi hypothetical protein 0.0035 0.002 0.0057
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.008 0.0068
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0071 0.008 0.0222
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0035 0.002 0.0057
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0041 0.0031 0.0019
Echinococcus granulosus RNA directed DNA polymerase 0.0035 0.002 0.0008
Schistosoma mansoni phosphoglucomutase 0.0153 0.0216 0.0652
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.0274 0.0776
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0081 0.0097 0.0277
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0071 0.008 0.0226
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0423 0.0662 0.2058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.2154 0.3526 1
Echinococcus multilocularis sentrin specific protease 8 0.0066 0.0072 0.006
Echinococcus granulosus sentrin specific protease 8 0.0066 0.0072 0.006
Brugia malayi Pao retrotransposon peptidase family protein 0.0035 0.002 0.0057
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.026 0.0392 0.0381
Trypanosoma cruzi polo-like protein kinase, putative 0.0112 0.0149 0.0422
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0188 0.0274 0.0776
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0081 0.0097 0.6221
Echinococcus granulosus high affinity choline transporter 1 0.0376 0.0584 0.0573
Echinococcus granulosus tumor protein p63 0.0332 0.0512 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0146 0.0204 0.0193
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0071 0.008 0.0226
Schistosoma mansoni serine/threonine protein kinase 0.1217 0.1976 0.6202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Mycobacterium ulcerans integral membrane protein 0.0041 0.0031 1
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0075 0.0088 0.0076
Leishmania major metacaspase, putative 0.0115 0.0152 0.0422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0149 0.021 0.0594
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.017 0.0483
Loa Loa (eye worm) hypothetical protein 0.0238 0.0357 0.1013
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0266 0.0402 0.6036
Loa Loa (eye worm) voltage-gated potassium channel 0.0071 0.008 0.0226
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0051 0.0679
Brugia malayi cation channel family protein 0.0071 0.008 0.0226
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.0097 0.1202
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0071 0.008 0.0226
Brugia malayi GH02984p 0.0376 0.0584 0.1658
Onchocerca volvulus 0.0041 0.0031 0.104
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0071 0.008 0.0068
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0097 0.0085
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0071 0.008 0.0222
Toxoplasma gondii hypothetical protein 0.0041 0.0031 0.0367
Echinococcus multilocularis conserved hypothetical protein 0.0071 0.008 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0049 0.014
Brugia malayi RNase H family protein 0.0153 0.0216 0.0613
Brugia malayi MH2 domain containing protein 0.0126 0.017 0.0483
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0066 0.0072 0.0812
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0115 0.0152 0.206
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.008 0.0068
Brugia malayi hypothetical protein 0.0035 0.002 0.0057
Echinococcus multilocularis solute carrier family 5 0.0041 0.0031 0.0019
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0423 0.0662 0.1878
Leishmania major hypothetical protein, conserved 0.0027 0.0007 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0097 0.0276
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0071 0.008 0.0068
Plasmodium vivax metacaspase 1, putative 0.0115 0.0152 1
Echinococcus granulosus potassium voltage gated channel protein 0.0071 0.008 0.0068
Schistosoma mansoni voltage-gated potassium channel 0.1733 0.2828 0.8889
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0146 0.0204 0.058
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0071 0.008 0.0222
Schistosoma mansoni voltage-gated potassium channel 0.0071 0.008 0.0222
Loa Loa (eye worm) hypothetical protein 0.0049 0.0043 0.0122
Trypanosoma brucei potassium voltage-gated channel, putative 0.0075 0.0088 0.0248
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.6221
Echinococcus granulosus ribonuclease H1 0.0153 0.0216 0.0204
Echinococcus multilocularis potassium voltage gated channel protein 0.0071 0.008 0.0068
Echinococcus granulosus dnaJ subfamily B 0.0402 0.0627 0.0616
Echinococcus granulosus potassium voltage gated channel protein 0.0071 0.008 0.0068
Echinococcus multilocularis caspase 2 0.0156 0.022 0.0209
Toxoplasma gondii FATC domain-containing protein 0.0238 0.0357 0.5348
Leishmania major hypothetical protein, conserved 0.0071 0.008 0.0221
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.2154 0.3526 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0097 0.0276
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.0276
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0081 0.0097 0.0277
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus multilocularis RNA directed DNA polymerase 0.0035 0.002 0.0008
Schistosoma mansoni hypothetical protein 0.0184 0.0268 0.0814
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0075 0.0088 0.0248
Echinococcus granulosus hypothetical protein 0.0071 0.008 0.0068
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.6221
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0075 0.0088 0.0248
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0423 0.0662 0.0651
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0071 0.008 0.0226
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0146 0.0204 0.058
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.1733 0.2828 0.8022
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0149 0.021 0.0198
Loa Loa (eye worm) phosphatidylinositol kinase 0.0081 0.0097 0.0276
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0081 0.0097 0.0276
Giardia lamblia Kinase, PLK 0.0112 0.0149 0.2003
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0022 0.0063
Trypanosoma brucei ingi protein (ORF1) 0.0188 0.0274 0.0776
Echinococcus multilocularis serine protein kinase ATM 0.0238 0.0357 0.0345
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0081 0.0097 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0238 0.0357 0.525
Trypanosoma cruzi ribonuclease H1, putative 0.0153 0.0216 0.0613
Schistosoma mansoni hypothetical protein 0.0036 0.0022 0.004
Loa Loa (eye worm) hypothetical protein 0.0071 0.008 0.0226
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0071 0.008 0.0068
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0081 0.0097 0.0085
Toxoplasma gondii transporter, cation channel family protein 0.0071 0.008 0.1115
Echinococcus multilocularis mitogen activated protein kinase 11 0.2154 0.3526 0.3518
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0348 0.0538 0.1526
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Echinococcus granulosus transient receptor potential cation channel 0.0071 0.008 0.0068
Schistosoma mansoni transient receptor potential channel 0.0071 0.008 0.0222
Leishmania major phosphatidylinositol 3-kinase, putative 0.0423 0.0662 0.1835
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0152 0.0214 0.0202
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0035 0.002 0.051
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0153 0.0216 0.5
Onchocerca volvulus 0.0075 0.0088 0.3704
Trypanosoma cruzi ribonuclease H1, putative 0.0153 0.0216 0.0613
Trichomonas vaginalis PIKK family atypical protein kinase 0.0423 0.0662 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0071 0.008 0.0222
Schistosoma mansoni voltage-gated ion channel 0.0071 0.008 0.0222
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0081 0.0097 0.0276
Plasmodium vivax kelch protein K13, putative 0.0075 0.0088 0.5551
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0071 0.008 0.0226
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Trypanosoma brucei CAAX amino terminal protease, putative 0.0199 0.0292 0.0827
Loa Loa (eye worm) hypothetical protein 0.0266 0.0402 0.1141
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0146 0.0204 0.0193
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0075 0.0088 0.0248
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0075 0.0088 0.1235
Schistosoma mansoni inositol transporter 0.0041 0.0031 0.0069
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0035 0.002 0.0008
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0081 0.0097 0.0085
Onchocerca volvulus Cell death protein 3 homolog 0.0156 0.022 1
Entamoeba histolytica hypothetical protein 0.0081 0.0097 0.1056
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0088 0.0248
Echinococcus granulosus caspase 3 0.0145 0.0203 0.0191
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.027
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0088 0.0246
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0081 0.0097 0.1202
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0112 0.0149 0.0412
Trypanosoma brucei metacaspase MCA2 0.0115 0.0152 0.0432
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0081 0.0097 0.1056
Echinococcus granulosus solute carrier family 5 0.0041 0.0031 0.0019
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0075 0.0088 0.0248
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0199 0.0292 0.0808
Echinococcus granulosus transient receptor potential gamma protein 0.0071 0.008 0.0068
Trypanosoma cruzi metacaspase, putative 0.0115 0.0152 0.0432
Trichomonas vaginalis CAMK family protein kinase 0.0112 0.0149 0.2003
Leishmania major hypothetical protein, conserved 0.2204 0.3608 1
Echinococcus granulosus voltage gated hydrogen channel 1 0.0071 0.008 0.0068
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0081 0.0097 0.0276
Loa Loa (eye worm) ion channel NompC 0.0071 0.008 0.0226
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0423 0.0662 0.2058
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0199 0.0292 0.0827
Brugia malayi Cell death protein 3 precursor 0.0156 0.022 0.0625
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0071 0.008 0.0222

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % In vitro agonist activity relative to angiotensin II measured in rabbit aorta strip assay. ChEMBL. 1920354
Activity (functional) = 11.4 % In vivo agonist activity expressed as percent activity relative to angiotensin II in rat blood pressure assay. ChEMBL. 1920354
ID50 (functional) = 25 ng min-1 rat-1 In vivo antagonist activity (ANG II like) expressed by blood pressure increase(mHg)produced by 1 mg bolus iv injection of compound in rats ChEMBL. 1920354
pA2 (functional) = 9 In vitro antagonist activity (ANG II like) expressed as percent activity relative to ANG II in rabbit aorta strip assay. ChEMBL. 1920354

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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