Detailed information for compound 401667

Basic information

Technical information
  • TDR Targets ID: 401667
  • Name: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R )-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-meth ylphenyl)propyl]amino]acetyl]amino]acetyl]ami no]-3-phenylpropanoyl]amino]-3-hydroxybutanoy l]amino]acetyl]amino]propanoyl]amino]-5-(diam inomethylideneamino)pentanoyl]amino]-N-[(2S)- 1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino) -1-[[(2S)-1,6-diamino-1-oxohexan-2-yl]amino]- 1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amin o]-3-hydroxy-1-oxopropan-2-yl]hexanamide
  • MW: 1381.63 | Formula: C62H104N22O14
  • H donors: 22 H acceptors: 14 LogP: -6.35 Rotable bonds: 59
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CCCCN)CCCN=C(N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC[C@H](Cc1ccc(cc1)C)N)C)CCCN=C(N)N
  • InChi: 1S/C62H104N22O14/c1-35-20-22-40(23-21-35)28-41(65)30-71-31-48(87)74-32-50(89)78-46(29-39-14-6-5-7-15-39)58(96)84-51(38(4)86)60(98)75-33-49(88)76-36(2)53(91)80-45(19-13-27-73-62(69)70)56(94)82-43(17-9-11-25-64)57(95)83-47(34-85)59(97)77-37(3)54(92)81-44(18-12-26-72-61(67)68)55(93)79-42(52(66)90)16-8-10-24-63/h5-7,14-15,20-23,36-38,41-47,51,71,85-86H,8-13,16-19,24-34,63-65H2,1-4H3,(H2,66,90)(H,74,87)(H,75,98)(H,76,88)(H,77,97)(H,78,89)(H,79,93)(H,80,91)(H,81,92)(H,82,94)(H,83,95)(H,84,96)(H4,67,68,72)(H4,69,70,73)/t36-,37-,38+,41-,42-,43-,44-,45-,46-,47-,51-/m0/s1
  • InChiKey: MVVASLBYFFXKLS-NQVOXGLYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-6-amino-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(p-tolyl)propyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]acetyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanamide
  • (2S)-6-amino-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[[(1S)-5-amino-1-carbamoylpentyl]amino]-oxomethyl]-4-guanidinobutyl]amino]-1-methyl-2-oxoethyl]amino]-1-(hydroxymethyl)-2-oxoethyl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(p-tolyl)propyl]amino]-1-oxoethyl]amino]-1-oxoethyl]amino]-1-oxo-3-phenylpropyl]amino]-3-hydroxy-1-oxobutyl]amino]-1-oxoethyl]amino]-1-oxopropyl]amino]-5-guanidino-1-oxopentyl]amino]hexanamide
  • (2S)-6-azanyl-2-[[(2S)-2-[[(2S)-2-[2-[[(2S,3R)-2-[[(2S)-2-[2-[2-[[(2S)-2-azanyl-3-(4-methylphenyl)propyl]amino]ethanoylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]ethanoylamino]propanoyl]amino]-5-[bis(azanyl)methylideneamino]pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-5-[bis(azanyl)methylideneamino]-1-[[(2S)-1,6-bis(azanyl)-1-oxo-hexan-2-yl]amino]-1-oxo-pentan-2-yl]amino]-1-oxo-propan-2-yl]amino]-3-hydroxy-1-oxo-propan-2-yl]hexanamide
  • (2S)-6-amino-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-4-guanidino-butyl]amino]-2-keto-1-methyl-ethyl]amino]-2-keto-1-methylol-ethyl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(p-tolyl)propyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]acetyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanamide
  • (2S)-6-amino-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-4-guanidino-butyl]amino]-1-methyl-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-methylphenyl)propyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]acetyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanamide
  • (2S)-6-amino-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[[(1S)-5-amino-1-carbamoylpentyl]amino]-oxomethyl]-4-guanidinobutyl]amino]-1-methyl-2-oxoethyl]amino]-1-(hydroxymethyl)-2-oxoethyl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-methylphenyl)propyl]amino]-1-oxoethyl]amino]-1-oxoethyl]amino]-1-oxo-3-phenylpropyl]amino]-3-hydroxy-1-oxobutyl]amino]-1-oxoethyl]amino]-1-oxopropyl]amino]-5-guanidino-1-oxopentyl]amino]hexanamide
  • (2S)-6-amino-N-[(1S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-5-amino-1-carbamoyl-pentyl]carbamoyl]-4-guanidino-butyl]amino]-2-keto-1-methyl-ethyl]amino]-2-keto-1-methylol-ethyl]-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-methylphenyl)propyl]amino]acetyl]amino]acetyl]amino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]acetyl]amino]propanoyl]amino]-5-guanidino-pentanoyl]amino]hexanamide
  • (2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[2-[[(2S,3R)-2-[[(2S)-2-[2-[2-[[(2S)-2-amino-3-(4-methylphenyl)propyl]amino]ethanoylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-3-hydroxy-butanoyl]amino]ethanoylamino]propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1,6-diamino-1-oxo-hexan-2-yl]amino]-1-oxo-pentan-2-yl]amino]-1-oxo-propan-2-yl]amino]-3-hydroxy-1-oxo-propan-2-yl]hexanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus opioid receptor-like 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily opioid receptor-like 1 367 aa 303 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0022 0.0011 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0066 0.01 0.1433
Giardia lamblia Hypothetical protein 0.0066 0.01 0.1485
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0011 0.0011
Toxoplasma gondii pyruvate kinase PyK1 0.0078 0.0123 0.1835
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0029 0.0029
Brugia malayi AKH receptor 0.0031 0.0029 0.0396
Echinococcus multilocularis 6 phosphofructokinase 0.0127 0.0223 0.0223
Leishmania major ATP-dependent phosphofructokinase 0.0127 0.0223 0.0612
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0029 0.0029
Toxoplasma gondii 6-phosphofructokinase 0.0034 0.0035 0.0503
Schistosoma mansoni neuropeptide receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Toxoplasma gondii endonuclease IV APN 0.0084 0.0136 0.2032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.0083 0.0656
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0066 0.01 0.01
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.1375
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Echinococcus multilocularis 0.0066 0.01 0.01
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0066 0.01 0.0795
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0011 0.0088
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0025 0.0355
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0019 0.0046
Echinococcus multilocularis G protein coupled receptor 139 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0073
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.01 0.1375
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0019 0.0759
Echinococcus granulosus alpha 1A adrenergic receptor 0.0031 0.0029 0.0029
Brugia malayi Tachykinin-like peptides receptor 99D 0.0031 0.0029 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Brugia malayi hypothetical protein 0.0022 0.0011 0.0135
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0066 0.01 0.1375
Entamoeba histolytica galactokinase, putative 0.0058 0.0083 0.1119
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0344 0.0665 0.1838
Toxoplasma gondii exonuclease III APE 0.0022 0.001 0.0127
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0011 0.0135
Onchocerca volvulus 0.0031 0.0029 0.1626
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0194 0.036 0.5213
Brugia malayi GnHR receptor homolog 0.0031 0.0029 0.0396
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0019 0.0759
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0194 0.036 0.1031
Loa Loa (eye worm) pyruvate kinase 0.0078 0.0123 0.1725
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0344 0.0665 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0031 0.0029 0.0396
Echinococcus granulosus peptide allatostatin:somatostatin 0.0031 0.0029 0.0029
Echinococcus multilocularis orexin receptor type 2 0.0031 0.0029 0.0029
Schistosoma mansoni P2X receptor subunit 0.0637 0.126 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0013
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0031 0.0029 0.0405
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0057
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0066 0.01 0.1375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Giardia lamblia Phosphatidylinositol 4-kinase 0.0066 0.01 0.1485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.015 0.0271 0.0271
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0066 0.01 0.1375
Trichomonas vaginalis conserved hypothetical protein 0.015 0.0271 0.3977
Leishmania major phosphatidylinositol kinase, putative 0.0066 0.01 0.0273
Echinococcus granulosus dro:myosuppressin receptor 0.0031 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0405 0.6032
Schistosoma mansoni amine GPCR 0.0031 0.0029 0.023
Trypanosoma cruzi galactokinase, putative 0.005 0.0068 0.0191
Schistosoma mansoni pyruvate kinase 0.004 0.0047 0.037
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0223 0.3332
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0011 0.0011
Brugia malayi hypothetical protein 0.0022 0.0011 0.0135
Onchocerca volvulus 0.0058 0.0083 0.6383
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0078 0.0123 0.5508
Echinococcus granulosus galactokinase 0.0058 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0013
Echinococcus multilocularis G-protein coupled receptor, putative 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0354
Echinococcus granulosus neuropeptide FF receptor 2 0.0031 0.0029 0.0029
Loa Loa (eye worm) pyruvate kinase 0.0078 0.0123 0.1725
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0154
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0344 0.0665 0.1909
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Brugia malayi hypoxia-induced factor 1 0.0175 0.0322 0.4655
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0019 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0035 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Echinococcus granulosus single minded 2 0.0042 0.0051 0.0051
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0031 0.0029 0.023
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0029 0.0029
Echinococcus granulosus serotonin receptor 0.0031 0.0029 0.0029
Echinococcus multilocularis neuropeptide FF receptor 2 0.0031 0.0029 0.0029
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0031 0.0029 0.1626
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0066 0.01 0.7238
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0066 0.01 0.01
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0029 0.023
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0019 0.0759
Echinococcus granulosus sex peptide receptor 0.0031 0.0029 0.0029
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0011 0.0011
Chlamydia trachomatis pyruvate kinase 0.0078 0.0123 0.9006
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0027 0.0261
Onchocerca volvulus 0.0031 0.0029 0.1626
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.0011 0.0135
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0005 0.0155
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0031 0.0029 0.0396
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0123 0.1725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0066 0.01 0.7238
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.0011 0.0088
Onchocerca volvulus 0.003 0.0026 0.1345
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0344 0.0665 0.5276
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0029 0.0405
Loa Loa (eye worm) hypothetical protein 0.0066 0.01 0.14
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0066 0.01 0.14
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0073
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0029 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.1728 0.3475 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0005 0.0155
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0011 0.0088
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0038 0.0043 0.0119
Schistosoma mansoni biogenic amine receptor 0.0031 0.0029 0.023
Entamoeba histolytica hypothetical protein 0.0022 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0154
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0034 0.0035 0.1511
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.7238
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0031 0.0029 0.0396
Schistosoma mansoni biogenic amine receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0154
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0344 0.0665 0.1909
Loa Loa (eye worm) phosphatidylinositol kinase 0.0066 0.01 0.14
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0027 0.0071
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0022 0.0011 0.0129
Echinococcus granulosus tachykinin peptides receptor 99D 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0084 0.0136 0.1907
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0344 0.0665 0.1838
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0038 0.0043 0.0501
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0127 0.0223 1
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0084 0.0136 0.1961
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.0225 0.3289
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0066 0.01 0.01
Schistosoma mansoni P2X receptor subunit 0.0316 0.0608 0.4822
Loa Loa (eye worm) RGS-3 protein 0.0022 0.0011 0.0154
Echinococcus granulosus pyruvate kinase 0.0078 0.0123 0.0123
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0344 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0281 0.0536 0.7484
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0216 0.0405 0.6082
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0066 0.01 0.0283
Echinococcus granulosus g-protein coupled receptor 0.0031 0.0029 0.0029
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0066 0.01 0.1485
Brugia malayi galactokinase family protein 0.0027 0.0021 0.0273
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0127 0.0223 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0066 0.01 0.01
Schistosoma mansoni flap endonuclease-1 0.0027 0.0021 0.017
Plasmodium vivax hypothetical protein 0.0066 0.01 0.7238
Onchocerca volvulus 0.0031 0.0029 0.1626
Mycobacterium ulcerans pyruvate kinase 0.0078 0.0123 0.5508
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0223 0.3246
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0038 0.0043 0.0501
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0027 0.0385
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Echinococcus multilocularis tumor protein p63 0.0393 0.0764 0.0764
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.001 0.0381
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0019 0.0244
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0066 0.01 0.0283
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0031 0.0029 0.0029
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.1375
Onchocerca volvulus 0.0031 0.0029 0.1626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0038 0.0043 0.0043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0057
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0128 0.0225 0.0644
Brugia malayi sulfakinin receptor protein 0.0031 0.0029 0.0396
Schistosoma mansoni galactokinase 0.0027 0.0021 0.0163
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0029 0.023
Trichomonas vaginalis conserved hypothetical protein 0.0128 0.0225 0.3289
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Brugia malayi putative neuropeptide receptor 0.0031 0.0029 0.0396
Echinococcus granulosus biogenic amine 5HT receptor 0.0031 0.0029 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0344 0.0665 0.965
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0029 0.0029
Echinococcus granulosus neuropeptide Y receptor 0.0031 0.0029 0.0029
Schistosoma mansoni neuropeptide receptor 0.0031 0.0029 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0223 0.3246
Brugia malayi FAT domain containing protein 0.015 0.0271 0.3912
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0344 0.0665 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0031 0.0029 0.023
Trypanosoma cruzi target of rapamycin kinase 3 0.0344 0.0665 0.1909
Echinococcus granulosus axis inhibition protein axin 0.0022 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0029 0.0029
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0084 0.0136 0.6098
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0034 0.0035 0.0381
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0019 0.0128
Mycobacterium ulcerans galactokinase 0.0058 0.0083 0.3698
Onchocerca volvulus Pyruvate kinase homolog 0.0078 0.0123 1
Echinococcus multilocularis neuropeptide receptor A26 0.0536 0.1054 0.1054
Loa Loa (eye worm) phosphofructokinase 0.0127 0.0223 0.3111
Brugia malayi Dopamine receptor 0.0031 0.0029 0.0396
Trypanosoma cruzi galactokinase, putative 0.0058 0.0083 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Echinococcus granulosus g protein coupled receptor 0.0031 0.0029 0.0029
Trichomonas vaginalis pyruvate kinase, putative 0.0078 0.0123 0.173
Brugia malayi larval opioid receptor 0.0031 0.0029 0.0396
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0038 0.0043 0.0341
Echinococcus multilocularis serotonin receptor 0.0031 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.0029 0.0025 0.0065
Echinococcus granulosus allatostatin A receptor 0.0031 0.0029 0.0029
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0031 0.0029 0.023
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0066 0.01 0.1375
Echinococcus granulosus tumor protein p63 0.0393 0.0764 0.0764
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0057
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0031 0.0029 0.023
Schistosoma mansoni P2X receptor subunit 0.0637 0.126 1
Brugia malayi PAS domain containing protein 0.0057 0.0081 0.1149
Onchocerca volvulus 0.0031 0.0029 0.1626
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0029 0.0029
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0011 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0019 0.0759
Onchocerca volvulus Pyruvate kinase homolog 0.0078 0.0123 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0136 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0019 0.0759
Brugia malayi hypothetical protein 0.0142 0.0253 0.3663
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0038 0.0043 0.0501
Schistosoma mansoni hypothetical protein 0.015 0.0271 0.2147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.01 0.1375
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0066 0.01 0.01
Loa Loa (eye worm) translation initiation factor 4E 0.0038 0.0043 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0013
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0066 0.01 0.01
Echinococcus multilocularis expressed protein 0.0435 0.0848 0.0848
Schistosoma mansoni adenoreceptor 0.0031 0.0029 0.023
Echinococcus granulosus pyruvate kinase 0.004 0.0047 0.0047
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Echinococcus granulosus neuropeptide receptor 0.0031 0.0029 0.0029
Echinococcus multilocularis Mevalonate galactokinase 0.0018 0.0002 0.0002
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0029 0.023
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0216 0.0405 0.6082
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.0011 0.0011
Brugia malayi PXA domain containing protein 0.0022 0.0011 0.0135
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Mycobacterium leprae conserved hypothetical protein 0.0022 0.0011 0.0401
Trichomonas vaginalis galactokinase, putative 0.0027 0.0021 0.0158
Schistosoma mansoni opsin-like receptor 0.0031 0.0029 0.023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0029 0.0029
Entamoeba histolytica hypothetical protein 0.0066 0.01 0.1375
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0194 0.036 0.5403
Onchocerca volvulus 0.0066 0.01 0.7942
Brugia malayi 6-phosphofructokinase 0.0127 0.0223 0.3215
Echinococcus multilocularis lamin 0.003 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Onchocerca volvulus 0.0042 0.0051 0.3564
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0031 0.0029 0.0029
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0031 0.0029 0.023
Echinococcus granulosus pyruvate kinase 0.0078 0.0123 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0344 0.0665 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0078 0.0123 0.035
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.0011 0.0011
Brugia malayi Pyruvate kinase, muscle isozyme 0.0078 0.0123 0.1771
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Onchocerca volvulus 0.0031 0.0029 0.1626
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0194 0.036 0.2857
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0066 0.01 0.7238
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0011 0.0088
Schistosoma mansoni amine GPCR 0.0031 0.0029 0.023
Mycobacterium leprae Probable pyruvate kinase PykA 0.0078 0.0123 0.5508
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0344 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0024
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0223 0.3111
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Echinococcus granulosus somatostatin receptor 0.0031 0.0029 0.0029
Leishmania major hypothetical protein, conserved 0.1795 0.361 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0066 0.01 0.0795
Brugia malayi phosphofructokinase 0.0127 0.0223 0.3215
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.01 0.14
Echinococcus multilocularis neuropeptide receptor 0.0031 0.0029 0.0029
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0019 0.0128
Echinococcus multilocularis transfer RNA-Lys 0.0042 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.1485
Mycobacterium tuberculosis Conserved hypothetical protein 0.0066 0.01 0.4457
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0066 0.01 0.1485
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.0011 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.01 0.14
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0066 0.01 0.0283
Loa Loa (eye worm) pyruvate kinase-PB 0.0054 0.0076 0.1058
Leishmania major pyruvate kinase 0.0078 0.0123 0.0337
Schistosoma mansoni growth hormone secretagogue receptor 0.0031 0.0029 0.023
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.7238
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0035 0.2281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0344 0.0665 0.0665
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0025 0.1532
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0029 0.0029
Schistosoma mansoni mevalonate kinase 0.0018 0.0002 0.0014
Mycobacterium ulcerans putative regulatory protein 0.0042 0.0051 0.2221
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0011 0.0011
Echinococcus multilocularis serine protein kinase ATM 0.0194 0.036 0.036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0066 0.01 0.1375
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.1375
Schistosoma mansoni lamin 0.003 0.0026 0.0205
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Schistosoma mansoni neuropeptide receptor 0.0031 0.0029 0.023
Echinococcus granulosus Mevalonate galactokinase 0.0018 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0011 0.0088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.001 0.038
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0038 0.0043 0.0501
Echinococcus multilocularis g protein coupled receptor 0.0031 0.0029 0.0029
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0031 0.0029 0.023
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0223 0.3246
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus granulosus intermediate filament protein 0.003 0.0026 0.0026
Echinococcus granulosus p2X purinoceptor 4 0.0637 0.126 0.126
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0223 0.3246
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0031 0.0029 0.0396
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0031 0.0029 0.023
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0031 0.0029 0.023
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.0011 0.0011
Schistosoma mansoni pyruvate kinase 0.0078 0.0123 0.098
Echinococcus granulosus nuclear factor of activated T cells 5 0.0086 0.014 0.014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0019 0.0759
Onchocerca volvulus 0.0031 0.0029 0.1626
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0073
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0011 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Trypanosoma cruzi galactokinase, putative 0.0058 0.0083 0.0235
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0031 0.0029 0.0029
Brugia malayi G-protein coupled receptor 0.0031 0.0029 0.0396
Onchocerca volvulus 0.003 0.0026 0.1345
Echinococcus multilocularis flap endonuclease 1 0.003 0.0027 0.0027
Echinococcus granulosus fmrfamide receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0259
Echinococcus multilocularis pyruvate kinase 0.004 0.0047 0.0047
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0038 0.0043 0.0622
Toxoplasma gondii FATC domain-containing protein 0.0194 0.036 0.5403
Loa Loa (eye worm) neuropeptide F receptor 0.0031 0.0029 0.0405
Schistosoma mansoni lamin 0.003 0.0026 0.0205
Loa Loa (eye worm) hypothetical protein 0.0128 0.0225 0.3151
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0194 0.036 0.5344
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0066 0.01 0.0283
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.01 0.1433
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0066 0.01 0.1375
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.0011 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0019 0.0759
Loa Loa (eye worm) phosphatidylinositol 3 0.0344 0.0665 0.929
Brugia malayi Dopamine receptor protein 1 0.0031 0.0029 0.0396
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0344 0.0665 0.5276
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0066 0.01 0.1485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0086 0.014 0.014
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.1485
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.001 0.038
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0194 0.036 0.1031
Brugia malayi Flap endonuclease-1 0.003 0.0027 0.0371
Onchocerca volvulus 0.0031 0.0029 0.1626
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0066 0.01 0.0283
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0038 0.0043 0.0501
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0154
Mycobacterium ulcerans hypothetical protein 0.0022 0.0011 0.0401
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0019 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0031 0.0029 0.0029
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.0011 0.0011
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0066 0.01 0.01
Toxoplasma gondii target of rapamycin (TOR), putative 0.0344 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0066 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0361
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.0011 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0029 0.0405
Entamoeba histolytica Flap nuclease, putative 0.003 0.0027 0.0261
Echinococcus multilocularis pyruvate kinase 0.0078 0.0123 0.0123
Entamoeba histolytica pyruvate kinase, putative 0.0054 0.0076 0.1001
Echinococcus granulosus orexin receptor type 2 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0259
Echinococcus granulosus neuropeptide receptor 0.0031 0.0029 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0025 0.0068
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0073
Schistosoma mansoni fkbp-rapamycin associated protein 0.0194 0.036 0.2857
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Echinococcus granulosus 7tm_1 domain containing protein 0.0031 0.0029 0.0029
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.0011 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0344 0.0665 0.929
Echinococcus multilocularis pyruvate kinase 0.004 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0066 0.01 0.14
Brugia malayi Pyruvate kinase, M2 isozyme 0.0078 0.0123 0.1771
Echinococcus granulosus g protein coupled receptor 0.0031 0.0029 0.0029
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0031 0.0029 0.0029
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0031 0.0029 0.0029
Entamoeba histolytica protein kinase rad3, putative 0.0194 0.036 0.5344
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus granulosus serine protein kinase ATM 0.0194 0.036 0.036
Loa Loa (eye worm) intermediate filament protein 0.003 0.0026 0.0361
Onchocerca volvulus 0.0026 0.0019 0.0701
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.01 0.1433
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.001 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0259
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0026 0.0361
Echinococcus multilocularis p2X purinoceptor 4 0.0637 0.126 0.126
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0035 0.0381
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0027 0.0385
Brugia malayi Dopamine receptor protein 2 0.0031 0.0029 0.0396
Echinococcus multilocularis pyruvate kinase 0.0078 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0345
Giardia lamblia Pyruvate kinase 0.0078 0.0123 0.1835
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.0081
Giardia lamblia Pyruvate kinase 0.004 0.0047 0.0677
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0031 0.0029 0.0029
Echinococcus granulosus hypothetical protein 0.0031 0.0029 0.0029
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.1375
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.001 0.001
Brugia malayi translation initiation factor 4E 0.0038 0.0043 0.06
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0035 0.0381
Toxoplasma gondii phosphofructokinase PFKII 0.0034 0.0035 0.0503
Onchocerca volvulus 0.0031 0.0029 0.1626
Loa Loa (eye worm) hypothetical protein 0.0075 0.0119 0.1657
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Brugia malayi RE15519p 0.0031 0.0029 0.0396
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0027 0.1683
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.001 0.0122
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0038 0.0043 0.0043
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0013
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.0011 0.0011
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0344 0.0665 0.1909
Echinococcus granulosus G protein coupled receptor 139 0.0031 0.0029 0.0029
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0194 0.036 0.036
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Schistosoma mansoni single-minded 0.0057 0.0081 0.0641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0216 0.0405 0.6032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0344 0.0665 1
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0022 0.0011 0.0401
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0066 0.01 0.1375
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0019 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0066 0.01 0.1485
Loa Loa (eye worm) pyruvate kinase 0.0078 0.0123 0.1725
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0034 0.0035 0.0503
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0066 0.01 0.1375
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0003 0.0057
Leishmania major phosphatidylinositol 3-kinase, putative 0.0344 0.0665 0.1838
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Schistosoma mansoni ap endonuclease 0.0022 0.001 0.0081
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0031 0.0029 0.0029
Schistosoma mansoni intermediate filament proteins 0.003 0.0026 0.0205
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0011 0.0088
Chlamydia trachomatis endonuclease IV 0.0084 0.0136 1
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0011 0.0088
Echinococcus multilocularis g-protein coupled receptor 0.0031 0.0029 0.0029
Brugia malayi follicle stimulating hormone receptor 0.0031 0.0029 0.0396
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.0011 0.0154
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0029 0.0029
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0019 0.0759
Schistosoma mansoni biogenic amine receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.01 0.14
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0031 0.0029 0.0405
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0066 0.01 0.7238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Plasmodium vivax hypothetical protein, conserved 0.0066 0.01 0.7238
Entamoeba histolytica hypothetical protein 0.0066 0.01 0.1375
Plasmodium vivax pyruvate kinase 2, putative 0.004 0.0047 0.316
Schistosoma mansoni alpha-1 adrenergic receptor 0.0031 0.0029 0.023
Brugia malayi neuropeptide F receptor 0.0031 0.0029 0.0396
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0127 0.0223 0.0636
Echinococcus granulosus lamin dm0 0.003 0.0026 0.0026
Entamoeba histolytica hypothetical protein 0.0066 0.01 0.1375
Brugia malayi 6-phosphofructokinase 0.0127 0.0223 0.3215
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.1375
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.01 0.1433
Onchocerca volvulus 0.0031 0.0029 0.1626
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0066 0.01 0.1485
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0031 0.0029 0.023
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0031 0.0029 0.0029
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.0011 0.0011
Brugia malayi bHLH-PAS transcription factor 0.0042 0.0051 0.0714
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.013 0.0229 0.1821
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0031 0.0029 0.0405
Echinococcus granulosus p2X purinoceptor 4 0.0637 0.126 0.126
Echinococcus granulosus N acetylgalactosamine kinase 0.0027 0.0021 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0066 0.01 0.0283
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus granulosus lamin 0.003 0.0026 0.0026
Echinococcus multilocularis fmrfamide receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.001 0.0142
Leishmania major eukaryotic translation initiation factor-like protein 0.0038 0.0043 0.0114
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.023
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0027 0.0385
Trichomonas vaginalis phosphofructokinase, putative 0.0127 0.0223 0.3246
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Echinococcus multilocularis somatostatin receptor 0.0031 0.0029 0.0029
Onchocerca volvulus Neuropeptide F receptor homolog 0.0031 0.0029 0.1626
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.0283
Loa Loa (eye worm) hypothetical protein 0.015 0.0271 0.378
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0154
Onchocerca volvulus 0.0031 0.0029 0.1626
Plasmodium falciparum pyruvate kinase 0.0078 0.0123 0.9006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Echinococcus granulosus p2X purinoceptor 4 0.0637 0.126 0.126
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0344 0.0665 1
Echinococcus granulosus g protein coupled receptor 0.0031 0.0029 0.0029
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0066 0.01 0.1375
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.001 0.001
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0223 0.3246
Trichomonas vaginalis pyruvate kinase, putative 0.0078 0.0123 0.173
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0356 0.0689 1
Trypanosoma brucei pyruvate kinase 1 0.0078 0.0123 0.1835
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0029 0.0029
Onchocerca volvulus 0.0031 0.0029 0.1626
Brugia malayi hypothetical protein 0.019 0.0352 0.509
Echinococcus granulosus neuropeptides capa receptor 0.0031 0.0029 0.0029
Entamoeba histolytica hypothetical protein 0.0066 0.01 0.1375
Brugia malayi G protein-coupled receptor 0.0031 0.0029 0.0396
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.01 0.1375
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0066 0.01 0.0283
Echinococcus granulosus pyruvate kinase 0.004 0.0047 0.0047
Schistosoma mansoni neuropeptide receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0151 0.0272 0.3799
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0035 0.2281
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0066 0.01 0.1485
Entamoeba histolytica hypothetical protein 0.0022 0.0011 0.0013
Plasmodium falciparum flap endonuclease 1 0.003 0.0027 0.1683
Brugia malayi G-protein coupled receptor 0.0031 0.0029 0.0396
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0066 0.01 0.01
Echinococcus granulosus 7TM GPCR rhodopsin 0.0031 0.0029 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0025 0.1532
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0066 0.01 0.0795
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.4942 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.01 0.14
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0026 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0025 0.1532
Schistosoma mansoni neuropeptide F-like receptor 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0029 0.0029
Leishmania major eukaryotic translation initiation factor-like 0.0038 0.0043 0.0114
Onchocerca volvulus 0.0031 0.0029 0.1626
Echinococcus granulosus neuropeptide s receptor 0.0536 0.1054 0.1054
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0084 0.0136 1
Mycobacterium ulcerans epimerase 0.0022 0.0011 0.0401
Echinococcus multilocularis lamin dm0 0.003 0.0026 0.0026
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.0011 0.0154
Echinococcus multilocularis sex peptide receptor 0.0031 0.0029 0.0029
Echinococcus multilocularis Zinc finger, PHD finger 0.0066 0.01 0.01
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.01 0.1433
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.7238
Onchocerca volvulus 0.0031 0.0029 0.1626
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0025 0.0068
Onchocerca volvulus 0.0031 0.0029 0.1626
Giardia lamblia GTOR 0.0344 0.0665 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0344 0.0665 0.1909
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0011 0.0088
Treponema pallidum galactokinase 0.005 0.0068 0.3007
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0019 0.0244
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.001 0.0381
Loa Loa (eye worm) TYRA-2 protein 0.0031 0.0029 0.0405
Echinococcus granulosus 6 phosphofructokinase 0.0127 0.0223 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Loa Loa (eye worm) galactokinase 0.0027 0.0021 0.0287
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0194 0.036 0.5213
Trypanosoma brucei galactokinase-like protein, putative 0.0039 0.0044 0.0636
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0344 0.0665 0.1838
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Schistosoma mansoni biogenic amine (5HT) receptor 0.0031 0.0029 0.023
Brugia malayi G protein-coupled receptor F59B2.13 0.0031 0.0029 0.0396
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.0011 0.0135
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.0011 0.0154
Echinococcus multilocularis galactokinase 0.0058 0.0083 0.0083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.01 0.1433
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus multilocularis dro:myosuppressin receptor 0.0031 0.0029 0.0029
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0066 0.01 0.1375
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0035 0.0381
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0038 0.0043 0.0501
Mycobacterium ulcerans hypothetical protein 0.0026 0.0019 0.0759
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0011 0.0401
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.0058 0.0083 0.3698
Echinococcus multilocularis allatostatin A receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0035 0.2281
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.0283
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0031 0.0029 0.0029
Loa Loa (eye worm) G-protein coupled receptor 0.0031 0.0029 0.0405
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.0011 0.0011
Echinococcus multilocularis serotonin receptor 0.0031 0.0029 0.0029
Echinococcus granulosus neuropeptide receptor A26 0.0536 0.1054 0.1054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0031 0.0029 0.0405
Echinococcus multilocularis neuropeptide Y receptor 0.0031 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Schistosoma mansoni amine GPCR 0.0031 0.0029 0.023
Echinococcus multilocularis musashi 0.003 0.0026 0.0026
Schistosoma mansoni opsin-like receptor 0.0031 0.0029 0.023
Leishmania major pyruvate kinase 0.0078 0.0123 0.0337
Echinococcus multilocularis N acetylgalactosamine kinase 0.0027 0.0021 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.0283
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0066 0.01 0.01
Brugia malayi Serotonin receptor 0.0031 0.0029 0.0396
Mycobacterium leprae conserved hypothetical protein 0.0066 0.01 0.4457
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0154
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0066 0.01 0.1375
Schistosoma mansoni amine GPCR 0.0031 0.0029 0.023
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0066 0.01 0.0795
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0038 0.0043 0.0622
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.023
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.1375
Loa Loa (eye worm) hypothetical protein 0.0054 0.0076 0.1058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.001 0.0127
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.0011 0.0088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0029 0.0029
Leishmania major galactokinase-like protein 0.0058 0.0083 0.0226
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.0011 0.0088
Echinococcus granulosus flap endonuclease 1 0.003 0.0027 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.001 0.0023
Brugia malayi neuropeptide F receptor 0.0031 0.0029 0.0396
Brugia malayi Melatonin receptor type 1A 0.0031 0.0029 0.0396
Echinococcus multilocularis p2X purinoceptor 4 0.0637 0.126 0.126
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Schistosoma mansoni axis inhibition protein axin 0.0022 0.0011 0.0088
Leishmania major phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.0273
Trypanosoma brucei pyruvate kinase 1, putative 0.0078 0.0123 0.1835
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.023
Echinococcus granulosus pyruvate kinase 0.004 0.0047 0.0047
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0038 0.0043 0.0119
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0344 0.0665 0.0665
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0149
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0066 0.01 0.1433
Loa Loa (eye worm) 6-phosphofructokinase 0.0127 0.0223 0.3111
Brugia malayi ORL1-like opioid receptor 0.0031 0.0029 0.0396
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0019 0.0759
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0031 0.0029 0.0396
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.0011 0.0154
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0027 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0344 0.0665 1
Echinococcus multilocularis neuropeptides capa receptor 0.0031 0.0029 0.0029
Echinococcus multilocularis p2X purinoceptor 4 0.0637 0.126 0.126
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0223 0.1767
Plasmodium falciparum pyruvate kinase 2 0.004 0.0047 0.316
Plasmodium vivax 6-phosphofructokinase, putative 0.0034 0.0035 0.2281
Schistosoma mansoni myosin xvIII 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0027 0.0021 0.0283
Loa Loa (eye worm) melatonin receptor type 1A 0.0031 0.0029 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0013
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0066 0.01 0.1375
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0066 0.01 0.0795
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0031 0.0029 0.0405
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0066 0.01 0.1485
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0194 0.036 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Schistosoma mansoni hypothetical protein 0.0031 0.0029 0.023
Loa Loa (eye worm) hypoxia-induced factor 1 0.0175 0.0322 0.4494
Trypanosoma cruzi galactokinase-like protein, putative 0.005 0.0068 0.0191
Brugia malayi hypothetical protein 0.0029 0.0025 0.0343
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Onchocerca volvulus 0.0066 0.01 0.7942
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0024 0.0013 0.017
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0344 0.0665 0.0665
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0066 0.01 0.0795
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0035 0.0381
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0066 0.01 0.1485
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0031 0.0029 0.0029
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0127 0.0223 1
Brugia malayi putative neuropeptide receptor NPR1 0.0031 0.0029 0.0396
Onchocerca volvulus 0.0031 0.0029 0.1626
Echinococcus granulosus expressed protein 0.0435 0.0848 0.0848
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0066 0.01 0.1375
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0038 0.0043 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0019 0.0244
Entamoeba histolytica phosphofructokinase, putative 0.0127 0.0223 0.3246
Schistosoma mansoni neuropeptide f receptor 76f 0.0031 0.0029 0.023
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Mycobacterium ulcerans endonuclease IV 0.0084 0.0136 0.6098
Schistosoma mansoni regulator of G protein signaling 0.0022 0.0011 0.0088
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0019 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0027 0.0381
Trypanosoma cruzi pyruvate kinase 2, putative 0.0078 0.0123 0.035
Schistosoma mansoni aryl hydrocarbon receptor 0.0057 0.0081 0.0641
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0025 0.0355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.001 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.036 0.5344
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0344 0.0665 0.1838
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.0011 0.0135
Loa Loa (eye worm) hypothetical protein 0.0369 0.0716 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0127 0.0223 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0034 0.0035 0.2281
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0066 0.01 0.01
Plasmodium vivax pyruvate kinase, putative 0.0078 0.0123 0.9006
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0031 0.0029 0.023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0019 0.0759
Loa Loa (eye worm) phosphatidylinositol 3 0.0066 0.01 0.14
Trichomonas vaginalis galactokinase, putative 0.0027 0.0021 0.0158
Loa Loa (eye worm) hypothetical protein 0.0216 0.0405 0.566
Entamoeba histolytica hypothetical protein 0.0194 0.036 0.5344
Toxoplasma gondii pyruvate kinase PyKII 0.004 0.0047 0.0677
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.0011 0.0013
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0066 0.01 0.01
Echinococcus multilocularis pyruvate kinase 0.0061 0.009 0.009
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0066 0.01 0.0273
Echinococcus multilocularis neuropeptide s receptor 0.0536 0.1054 0.1054
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0011 0.0088
Schistosoma mansoni 6-phosphofructokinase 0.0127 0.0223 0.1767
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Onchocerca volvulus 0.0031 0.0029 0.1626
Schistosoma mansoni histamine h1 receptor 0.0031 0.0029 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0066 0.01 0.1375
Onchocerca volvulus Pyruvate kinase homolog 0.0078 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.019 0.0352 0.4912
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0066 0.01 0.1485
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.0011 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0344 0.0665 0.965
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.001 0.0024
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0034 0.0035 0.0503
Loa Loa (eye worm) hypothetical protein 0.0194 0.036 0.503
Echinococcus multilocularis pyruvate kinase 0.004 0.0047 0.0047
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0034 0.0035 0.0381
Leishmania major hypothetical protein, unknown function 0.0066 0.01 0.0273
Brugia malayi hypothetical protein 0.0031 0.0029 0.0396
Leishmania major phosphatidylinositol 4-kinase, putative 0.0066 0.01 0.0273
Trichomonas vaginalis galactokinase, putative 0.0027 0.0021 0.0158
Leishmania major phosphatidylinositol kinase related protein, putative 0.0066 0.01 0.0273
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.015 0.0271 0.0271
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0066 0.01 0.0795
Trichomonas vaginalis galactokinase, putative 0.0027 0.0021 0.0158
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0084 0.0136 0.6098
Schistosoma mansoni opsin-like receptor 0.0031 0.0029 0.023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0031 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0058 0.0083 0.1155
Brugia malayi intermediate filament protein 0.003 0.0026 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0029 0.0405
Brugia malayi Serotonin receptor 0.0031 0.0029 0.0396
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0066 0.01 0.1375
Schistosoma mansoni amine GPCR 0.0031 0.0029 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.001 0.0381
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0944 0.1883 0.1883
Echinococcus granulosus tm gpcr rhodopsin 0.0031 0.0029 0.0029
Trichomonas vaginalis phosphofructokinase, putative 0.0034 0.0035 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0031 0.0029 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0344 0.0665 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0073
Brugia malayi hypothetical protein 0.0019 0.0004 0.0035
Schistosoma mansoni P2X receptor subunit 0.0316 0.0608 0.4822
Schistosoma mansoni hypothetical protein 0.0066 0.01 0.0795
Schistosoma mansoni pyruvate kinase 0.0078 0.0123 0.098
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0034 0.0035 0.2281
Brugia malayi PXA domain containing protein 0.0022 0.0011 0.0135
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0066 0.01 0.1485

Activities

Activity type Activity value Assay description Source Reference
Emax (functional) % Potency (Emax) of the compound against electrically evoked contraction (twitch response) in mouse vas deferens; NA means Inactive up to 10 uM ChEMBL. 10956188
Emax (functional) 0 % Potency (Emax) of the compound against electrically evoked contraction (twitch response) in mouse vas deferens; NA means Inactive up to 10 uM ChEMBL. 10956188
Ki (binding) = -6.2 Affinity to nociceptin receptors on mouse forebrain membranes by [3H]-NC-NH2 displacement. ChEMBL. 10956188
Log EC50 (functional) Compound was tested for agonistic activity against electrically evoked contraction (twitch response) in mouse vas deferens; NA means Inactive up to 10 uM ChEMBL. 10956188
Log EC50 (functional) 0 Compound was tested for agonistic activity against electrically evoked contraction (twitch response) in mouse vas deferens; NA means Inactive up to 10 uM ChEMBL. 10956188
Log Ki (binding) = 6.2 Affinity to nociceptin receptors on mouse forebrain membranes by [3H]-NC-NH2 displacement. ChEMBL. 10956188
pKB (functional) = 5.7 Compound was tested for the antagonistic activity on mouse vas deferens using NC(1-13)NH2 as agonist ChEMBL. 10956188
pKB (functional) = 5.7 Compound was tested for the antagonistic activity on mouse vas deferens using NC(1-13)NH2 as agonist ChEMBL. 10956188

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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