TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 1045.19 | Formula: C50H72N14O11
H donors: 13 H acceptors: 12 LogP: -2.39 Rotable bonds: 37
Rule of 5 violations (Lipinski): 4
SMILES: CCCCC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)Cc1ccccc1)Cc1nc[nH]c1)NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(CC(=O)N)N)CCCN=C(N)N)Cc1ccc(cc1)O
InChi: 1S/C50H72N14O11/c1-4-5-13-34(43(68)61-37(24-31-26-55-27-57-31)48(73)64-21-10-15-39(64)46(71)62-38(49(74)75)23-29-11-7-6-8-12-29)59-45(70)36(22-30-16-18-32(65)19-17-30)60-47(72)41(28(2)3)63-44(69)35(14-9-20-56-50(53)54)58-42(67)33(51)25-40(52)66/h6-8,11-12,16-19,26-28,33-39,41,65H,4-5,9-10,13-15,20-25,51H2,1-3H3,(H2,52,66)(H,55,57)(H,58,67)(H,59,70)(H,60,72)(H,61,68)(H,62,71)(H,63,69)(H,74,75)(H4,53,54,56)
InChiKey: PRTAIRIYLQOGOC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0413	0.0615	0.0612
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0022	0.0003	0.0003
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	0.0612
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0036	0.0036
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0413	0.0615	0.0615
Loa Loa (eye worm)	phosphatidylinositol 3	0.2147	0.3332	0.3332
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0413	0.0615	0.0615
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0413	0.0615	0.0615
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0013	0.0013
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.6402	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Trichomonas vaginalis	fk506-binding protein, putative	0.0058	0.0058	0.0055
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0413	0.0615	0.0615
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0013	0.0011
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5466	0.8533	0.8533
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5092	0.7947	0.7947
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0413	0.0615	0.0612
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0031	0.0016	0.0016
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0936	0.1435	0.1435
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0413	0.0615	0.0615
Toxoplasma gondii	cathepsin CPL	0.0044	0.0036	0.0048
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1211	0.1865	0.1865
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0029	0.0013	0.0011
Toxoplasma gondii	target of rapamycin (TOR), putative	0.4761	0.7429	1
Entamoeba histolytica	hypothetical protein	0.0413	0.0615	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3457	0.5385	0.5383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0798	0.1218	0.1215
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.005	0.0046	0.0046
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0413	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.1305	0.2012	0.2012
Entamoeba histolytica	hypothetical protein	0.0413	0.0615	0.0612
Schistosoma mansoni	voltage-gated potassium channel	0.0169	0.0233	0.0233
Onchocerca volvulus		0.0044	0.0036	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3787	0.5903	0.5902
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0003	0.0003
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0031	0.0016	0.0016
Onchocerca volvulus		0.0044	0.0036	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1718	0.2659	0.2657
Leishmania major	peptidylprolyl isomerase-like protein	0.0058	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0022	0.0003	0.0003
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0413	0.0615	0.0615
Entamoeba histolytica	protein kinase, putative	0.0033	0.0019	0.0017
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0031	0.0016	0.0013
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0029	0.0013	0.0013
Toxoplasma gondii	AGC kinase	0.0031	0.0016	0.0022
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0022	0.0003	0.0003
Onchocerca volvulus		0.0044	0.0036	0.0376
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0036	0.0036
Entamoeba histolytica	protein kinase rad3, putative	0.1211	0.1865	0.1863
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.2147	0.3332	0.333
Schistosoma mansoni	60S ribosomal protein L21	0.0024	0.0006	0.0006
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0058	0.0058	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2147	0.3332	0.333
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0045	0.0038	0.0038
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1211	0.1865	0.1865
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0155	0.021	0.021
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0413	0.0615	0.0612
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0413	0.0615	0.0828
Loa Loa (eye worm)	hypothetical protein	0.005	0.0046	0.0046
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0058	0.0058	0.0058
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1349	0.2082	0.2802
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0019	0.0019
Plasmodium vivax	vivapain-2	0.0044	0.0036	0.0542
Entamoeba histolytica	protein kinase, putative	0.0031	0.0016	0.0013
Onchocerca volvulus		0.0044	0.0036	0.0376
Plasmodium vivax	hypothetical protein	0.0413	0.0615	1
Echinococcus multilocularis	cysteine protease	0.0044	0.0036	0.0036
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0031	0.0016	0.0013
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0031	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0936	0.1435	0.1435
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0058	0.0058	0.0055
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1211	0.1865	0.1865
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.6402	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0031	0.0016	0.0016
Trypanosoma cruzi	cruzipain precursor, putative	0.0044	0.0036	0.0033
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1211	0.1865	0.1865
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2147	0.3332	0.333
Leishmania major	hypothetical protein, conserved	0.0413	0.0615	0.0615
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3457	0.5385	0.5383
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	0.0612
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1211	0.1865	0.1863
Echinococcus multilocularis	cysteine protease	0.0044	0.0036	0.0036
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0413	0.0615	0.0615
Schistosoma mansoni	immunophilin	0.0058	0.0058	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.6402	1	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0036	0.0036
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0413	0.0615	0.0828
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0044	0.0036	0.0036
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0058	0.0058	0.0058
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	0.0612
Echinococcus multilocularis	cathepsin L	0.0022	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0413	0.0615	0.0615
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0413	0.0615	0.0615
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.005	0.0046	0.0046
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	conserved hypothetical protein	0.0798	0.1218	0.1215
Echinococcus granulosus	hyperpolarization activated cyclic	0.0031	0.0016	0.0016
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0031	0.0016	0.0016
Brugia malayi	FAT domain containing protein	0.0936	0.1435	0.1435
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3825	0.5962	0.5961
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0413	0.0615	0.0615
Schistosoma mansoni	voltage-gated potassium channel	0.0031	0.0016	0.0016
Brugia malayi	Papain family cysteine protease containing protein	0.0044	0.0036	0.0036
Onchocerca volvulus	Cathepsin F homolog	0.0044	0.0036	0.0376
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0413	0.0615	0.0612
Plasmodium falciparum	peptidyl-prolyl cis-trans isomerase FKBP35	0.0058	0.0058	0.0946
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3787	0.5903	0.5902
Loa Loa (eye worm)	phosphatidylinositol 3	0.0413	0.0615	0.0615
Entamoeba histolytica	hypothetical protein	0.0413	0.0615	0.0612
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0413	0.0615	0.0615
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0058	0.0058	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3451	0.5376	0.5375
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0615
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.0615	0.0612
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0413	0.0615	0.056
Plasmodium vivax	vivapain-2	0.0044	0.0036	0.0542
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0413	0.0615	0.0612
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0038	0.0038
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0413	0.0615	0.0615
Onchocerca volvulus		0.0044	0.0036	0.0376
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.6402	1	1
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0036	0.0036
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0058	0.0058	0.0055
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0036	0.0033
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.6402	1	1
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0016	0.0016
Onchocerca volvulus		0.0044	0.0036	0.0376
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0058	0.0058	0.0055
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.5097	0.7956	0.7955
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Loa Loa (eye worm)	cysteine protease	0.0044	0.0036	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Echinococcus granulosus	cysteine protease	0.0022	0.0003	0.0003
Toxoplasma gondii	FATC domain-containing protein	0.1211	0.1865	0.251
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0003	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0013	0.0011
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0413	0.0615	0.0615
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Entamoeba histolytica	hypothetical protein	0.1211	0.1865	0.1863
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0413	0.0615	0.0615
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2147	0.3332	0.333
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.6402	1	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0413	0.0615	0.0615
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0413	0.0615	0.0615
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0036	0.0036
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0031	0.0016	0.0016
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3451	0.5376	0.5375
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3825	0.5962	0.5961
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0036	0.0033
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0058	0.0058	0.0055
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0058	0.0058	0.0058
Echinococcus granulosus	cathepsin l1	0.0029	0.0013	0.0013
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.5097	0.7956	0.7956
Entamoeba histolytica	cysteine proteinase, putative	0.0044	0.0036	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0798	0.1218	0.1218
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0413	0.0615	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1211	0.1865	0.1863
Loa Loa (eye worm)	hypothetical protein	0.0413	0.0615	0.0615
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0031	0.0016	0.0016
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0413	0.0615	0.0612
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6402	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	0.0612
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2659	0.4135	0.4133
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0045	0.0038	0.0038
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.2147	0.3332	0.3332
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0413	0.0615	0.0612
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Loa Loa (eye worm)	ctsf protein	0.0044	0.0036	0.0036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0044	0.0036	0.0033
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0031	0.0016	0.0016
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Echinococcus granulosus	cathepsin L	0.0022	0.0003	0.0003
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0058	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0003	0.0003
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0798	0.1218	0.1215
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0413	0.0615	0.0615
Schistosoma mansoni	immunophilin	0.0058	0.0058	0.0058
Onchocerca volvulus		0.0044	0.0036	0.0376
Leishmania major	phosphatidylinositol 3-kinase, putative	0.2147	0.3332	0.3332
Giardia lamblia	GTOR	0.6402	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0413	0.0615	0.0612
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0195	0.0192
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0036	0.0036
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0013	0.0013
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0044	0.0036	0.0585
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0031	0.0016	0.0016
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0413	0.0615	0.0612
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0413	0.0615	0.0615
Schistosoma mansoni	voltage-gated potassium channel	0.0169	0.0233	0.0233
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0044	0.0036	0.0036
Leishmania major	fk506-binding protein 1-like protein	0.0058	0.0058	0.0058
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0044	0.0036	0.0585
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6402	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0413	0.0615	0.0828
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.0615	0.0615
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.2147	0.3332	0.3332
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0013
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0413	0.0615	1
Loa Loa (eye worm)	hypothetical protein	0.1211	0.1865	0.1865
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5092	0.7947	0.7947
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0003	0.0003
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.3027	0.4712	0.4711
Onchocerca volvulus		0.0413	0.0615	1
Schistosoma mansoni	voltage-gated potassium channel	0.0045	0.0038	0.0038
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0058	0.0058	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1211	0.1865	0.1863
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0413	0.0615	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2147	0.3332	0.333
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3457	0.5385	0.5383
Loa Loa (eye worm)	phosphatidylinositol 3	0.0413	0.0615	0.0615
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0413	0.0615	0.0612
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1211	0.1865	0.1865
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0413	0.0615	0.0612
Mycobacterium leprae	conserved hypothetical protein	0.0413	0.0615	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.6402	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0413	0.0615	0.0615
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0413	0.0615	0.0615
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0413	0.0615	0.0615
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0413	0.0615	0.0615
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0058	0.0058	0.0055
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0155	0.021	0.021
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0044	0.0036	0.0585
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4156	0.648	0.6479
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0036	0.0036
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.2147	0.3332	0.3332
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0413	0.0615	0.0615
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0031	0.0016	0.0016
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0413	0.0615	0.0612
Echinococcus multilocularis	voltage gated potassium channel	0.0045	0.0038	0.0038
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0013	0.0013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.6402	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0036	0.0033
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0031	0.0016	0.0016
Echinococcus granulosus	cathepsin L cysteine protease	0.0022	0.0003	0.0003
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0058	0.0058	0.0058
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0413	0.0615	0.0615
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.2147	0.3332	0.333
Loa Loa (eye worm)	phosphatidylinositol 3	0.6402	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0044	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3825	0.5962	0.5961
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2147	0.3332	0.333
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0036	0.0033
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0155	0.021	0.021
Brugia malayi	cathepsin L-like precursor	0.0029	0.0013	0.0013
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0019	0.0017
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.6402	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0413	0.0615	0.0615
Loa Loa (eye worm)	phosphatidylinositol 3	0.0413	0.0615	0.0615
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0031	0.0016	0.0016
Loa Loa (eye worm)	fibroinase	0.0044	0.0036	0.0036
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0413	0.0615	0.0615
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0058	0.0058	0.0905
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.6402	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Leishmania major	hypothetical protein, unknown function	0.0413	0.0615	0.0615
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0022	0.0003	0.0046
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0413	0.0615	0.056
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0045	0.0038	0.0038
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0058	0.0058	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2147	0.3332	0.333
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.2147	0.3332	0.333
Leishmania major	cysteine peptidase A (CPA)	0.0044	0.0036	0.0036
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0006	0.0006
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5092	0.7947	0.7947
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.2147	0.3332	0.3332
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0413	0.0615	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0036	0.0036
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0413	0.0615	0.0615
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0058	0.0058	0.0055
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0413	0.0615	0.5
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0413	0.0615	0.0828
Echinococcus granulosus	serine protein kinase ATM	0.1211	0.1865	0.1865
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5092	0.7947	0.7947
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0413	0.0615	0.0828
Echinococcus multilocularis	serine protein kinase ATM	0.1211	0.1865	0.1865
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0044	0.0036	0.0036
Giardia lamblia	Hypothetical protein	0.0413	0.0615	0.056
Trypanosoma cruzi	target of rapamycin kinase 3	0.5097	0.7956	0.7955
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0155	0.021	0.021
Plasmodium vivax	hypothetical protein, conserved	0.0413	0.0615	1
Leishmania major	cathepsin L-like protease	0.0044	0.0036	0.0036
Schistosoma mansoni	cathepsin F (C01 family)	0.0044	0.0036	0.0036
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0058	0.0058	0.0055
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Entamoeba histolytica	cysteine protease, putative	0.0044	0.0036	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0019	0.0019
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.6402	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.0615	0.0615
Trichomonas vaginalis	conserved hypothetical protein	0.0936	0.1435	0.1432
Trichomonas vaginalis	conserved hypothetical protein	0.1349	0.2082	0.208
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1211	0.1865	0.1865
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0413	0.0615	0.0612
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.0615	0.0615
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0031	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0936	0.1435	0.1435
Entamoeba histolytica	protein kinase, putative	0.0033	0.0019	0.0017
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0145	0.0195	0.0192
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0413	0.0615	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4294	0.6697	0.6696
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0031	0.0016	0.0016
Leishmania major	phosphatidylinositol kinase, putative	0.0413	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.0016
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0413	0.0615	0.0612
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0413	0.0615	0.0612
Brugia malayi	Cathepsin L-like precursor	0.0044	0.0036	0.0036
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	1
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0036	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Onchocerca volvulus		0.0413	0.0615	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Echinococcus granulosus	cathepsin l1	0.0044	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.0615	0.0615
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.0013	0.0013
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0058	0.0058	0.0055
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0031	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.1349	0.2082	0.2082
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.6402	1	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0031	0.0016	0.0016
Echinococcus granulosus	voltage gated potassium channel	0.0045	0.0038	0.0038
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	0.0615
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0413	0.0615	0.0615
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0413	0.0615	0.0612
Echinococcus multilocularis	fk506 binding protein	0.0058	0.0058	0.0058
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0413	0.0615	0.0615
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0044	0.0036	0.0036
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0413	0.0615	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0038	0.0038
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0413	0.0615	0.056
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0019	0.0017
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0016	0.0016
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0058	0.0058	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0013	0.0011
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1211	0.1865	0.1863
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0936	0.1435	0.1435
Echinococcus granulosus	hyperpolarization activated cyclic	0.0031	0.0016	0.0016
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0003	0.0003
Trichomonas vaginalis	immunophilin, putative	0.0058	0.0058	0.0055
Onchocerca volvulus	Cathepsin L homolog	0.0044	0.0036	0.0376
Trypanosoma cruzi	cysteine peptidase, putative	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Schistosoma mansoni	hypothetical protein	0.0413	0.0615	0.0615
Schistosoma mansoni	immunophilin	0.005	0.0046	0.0046
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1211	0.1865	0.1863
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4761	0.7429	0.7428
Echinococcus multilocularis		0.0413	0.0615	0.0615
Entamoeba histolytica	hypothetical protein	0.0413	0.0615	0.0612
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1211	0.1865	0.1863
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0031	0.0016	0.0016
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0058	0.0058	0.0055
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	0.0612
Loa Loa (eye worm)	FKBP5 protein	0.0058	0.0058	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3451	0.5376	0.5375
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0044	0.0036	0.0033
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.0615	0.0615
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0178	0.0178
Echinococcus multilocularis	cathepsin L cysteine protease	0.0044	0.0036	0.0036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3457	0.5385	0.5383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5092	0.7947	0.7947
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0413	0.0615	0.0615
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0413	0.0615	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0044	0.0036	0.0033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1211	0.1865	0.1863
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.2147	0.3332	0.3332
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0044	0.0036	0.0033

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 21 %	In vivo residual angiotensin II like activity of the compound was determined in an rat blood pressure assay	ChEMBL.	2913307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: 337213

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 404373