Detailed information for compound 419146

Basic information

Technical information
  • TDR Targets ID: 419146
  • Name: 5,5-bis(4-fluorophenyl)-3-phenylimidazolidine -2,4-dione
  • MW: 364.345 | Formula: C21H14F2N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.08 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1(NC(=O)N(C1=O)c1ccccc1)c1ccc(cc1)F
  • InChi: 1S/C21H14F2N2O2/c22-16-10-6-14(7-11-16)21(15-8-12-17(23)13-9-15)19(26)25(20(27)24-21)18-4-2-1-3-5-18/h1-13H,(H,24,27)
  • InChiKey: ORMFCWJFMCARPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,5-bis(4-fluorophenyl)-3-phenyl-imidazolidine-2,4-dione
  • 5,5-bis(4-fluorophenyl)-3-phenyl-hydantoin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0019 0.0019
Leishmania major DNA polymerase kappa, putative 0.0063 0.0963 0.1443
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0019 0.0047
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.2119 0.5197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0019 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0019 0.0047
Brugia malayi Pre-SET motif family protein 0.0031 0.026 0.026
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1113 0.1667
Echinococcus multilocularis zinc finger protein 0.0021 0.0018 0.0044
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.2119 1
Echinococcus granulosus transcription factor Dp 1 0.004 0.0457 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0019 0.0019
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0088 0.0136
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.2927 0.4383
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2119 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0049 0.0662 0.1625
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Loa Loa (eye worm) phosphofructokinase 0.0115 0.2119 0.2119
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.1435 0.2149
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0045 0.0562 0.0562
Loa Loa (eye worm) DEAH box polypeptide 35 0.0163 0.32 0.32
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0457 0.1122
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.2119 0.3174
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0019 0.0019
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0808 0.3812
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.1435 0.4338
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0319 0.6677 1
Brugia malayi nuclear hormone receptor 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0681 0.0681
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0019 0.0047
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0019 0.0019
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0019 0.0047
Schistosoma mansoni hypothetical protein 0.0022 0.0043 0.0066
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0808 0.1246
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0448 0.0672
Loa Loa (eye worm) MBCTL1 0.0057 0.0837 0.0837
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0019 0.0047
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0249 0.5551
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0019 0.0029
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0249 0.3531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2119 0.4122
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0019 0.0047
Brugia malayi glutathione reductase 0.004 0.0448 0.0448
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0019 0.0047
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.1113 0.1113
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0558 0.0835
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.1409 0.2109
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0019 0.0029
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2119 0.2119
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0546 0.7737
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.2119 1
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.2119 0.6408
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2119 0.3269
Onchocerca volvulus 0.0467 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.1279 0.1916
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.2119 0.6408
Leishmania major mitochondrial DNA polymerase beta 0.0319 0.6677 1
Brugia malayi 6-phosphofructokinase 0.0115 0.2119 0.2119
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0019 0.0019
Giardia lamblia DINP protein human, muc B family 0.0063 0.0963 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0019 0.0029
Onchocerca volvulus 0.025 0.5142 0.5132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0019 0.0047
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0681 0.1671
Mycobacterium ulcerans hypothetical protein 0.0168 0.3307 1
Brugia malayi Bromodomain containing protein 0.004 0.046 0.046
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.6677 1
Echinococcus granulosus dna polymerase kappa 0.0084 0.1435 0.3518
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0467 1 1
Schistosoma mansoni hypothetical protein 0.031 0.6483 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0019 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0019 0.0019
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0249 0.0484
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.1113 0.1113
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0019 0.0047
Trypanosoma brucei unspecified product 0.0077 0.1279 0.1916
Schistosoma mansoni DNA polymerase eta 0.0083 0.1409 0.2173
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.026 0.0639
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0808 0.1981
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0575 0.0861
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0249 0.5551
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0662 0.1022
Trypanosoma brucei trypanothione reductase 0.004 0.0448 0.0672
Brugia malayi ecdysteroid receptor 0.0021 0.0019 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0019 0.0047
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0049 0.0662 0.1625
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0572 0.0856
Leishmania major DNA polymerase eta, putative 0.0083 0.1409 0.2109
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2119 0.3174
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0091 0.1591 0.4811
Echinococcus granulosus dna polymerase eta 0.0083 0.1409 0.3454
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0235 0.0575
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0249 0.3531
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0808 0.1246
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0963 0.2913
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0019 0.0047
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1113 0.1667
Loa Loa (eye worm) hypothetical protein 0.0083 0.1409 0.1409
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0964 0.2364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0019 0.0047
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0681 0.1051
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.2119 0.3269
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0019 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0019 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0091 0.1591 0.4811
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0319 0.6677 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0249 0.0484
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0249 0.2584
Loa Loa (eye worm) hypothetical protein 0.0163 0.32 0.32
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0019 0.0019
Mycobacterium tuberculosis Probable reductase 0.0091 0.1591 0.4811
Plasmodium falciparum glutathione reductase 0.004 0.0448 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0019 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0575 0.0861
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.1113 0.2729
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.1409 0.1409
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0963 0.1443
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2119 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0019 0.0047
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0019 0.0019
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0681 0.1671
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0404 0.099
Brugia malayi mbt repeat family protein 0.005 0.0681 0.0681
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0019 0.0029
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.1113 0.2729
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2119 0.4122
Loa Loa (eye worm) hypothetical protein 0.005 0.0681 0.0681
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.3307 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0019 0.0019
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0249 0.5551
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0049 0.0662 0.1022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0808 0.2443
Schistosoma mansoni zinc finger protein 0.0021 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0045 0.0572 0.0572
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0808 0.0808
Brugia malayi nuclear receptor NHR-88 0.0021 0.0019 0.0019
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0084 0.1435 0.2791
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0019 0.0019
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0681 0.1671
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.026 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0019 0.0019
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.2119 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.026 0.3693
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.1435 0.2149
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0019 0.0047
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0837 0.2052
Echinococcus multilocularis dna polymerase eta 0.0083 0.1409 0.3454
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0837 0.1291
Loa Loa (eye worm) hypothetical protein 0.0467 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0558 0.0835
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0019 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.2927 0.4383
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0019 0.0019
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0019 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.2119 0.5197
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0101 0.1818 0.5497
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.1435 0.4338
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0249 0.0484
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0777 0.1163
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0681 0.1671
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.004 0.0461 0.0461
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0019 0.0019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0558 0.0835
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0249 0.0484
Brugia malayi PHD-finger family protein 0.0026 0.0144 0.0144
Trypanosoma brucei unspecified product 0.0039 0.042 0.0628
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0249 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2119 0.4122
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0546 0.0817
Loa Loa (eye worm) hypothetical protein 0.0043 0.0517 0.0517
Mycobacterium tuberculosis Probable dehydrogenase 0.0091 0.1591 0.4811
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0088 0.0216
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.1113 0.1667
Trichomonas vaginalis set domain proteins, putative 0.025 0.5142 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0019 0.0019
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0249 0.1175
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0681 0.0664
Brugia malayi Probable ATP-dependent helicase DHX35 0.0163 0.32 0.32
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.2927 0.4383
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0019 0.0019
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0681 0.1051
Mycobacterium tuberculosis Probable oxidoreductase 0.0101 0.1818 0.5497
Brugia malayi Bromodomain containing protein 0.0079 0.1325 0.1325
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.046 0.1129
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0019 0.0029
Loa Loa (eye worm) hypothetical protein 0.0075 0.1224 0.1224
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0964 0.2364
Plasmodium vivax SET domain protein, putative 0.0031 0.026 0.5807
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0808 0.1981
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0019 0.0019
Brugia malayi steroid hormone receptor 0.0021 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0019 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0019 0.0019
Plasmodium vivax glutathione reductase, putative 0.004 0.0448 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0249 0.0484
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0 0.5
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0558 0.0835
Loa Loa (eye worm) hypothetical protein 0.0057 0.0837 0.0837
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.4464 0.4464
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0249 0.5551
Brugia malayi Thioredoxin reductase 0.004 0.0448 0.0448
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0019 0.0047
Echinococcus multilocularis dna polymerase kappa 0.0084 0.1435 0.3518
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.2119 0.2119
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0837 0.2052
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.1113 0.1717
Brugia malayi 6-phosphofructokinase 0.0115 0.2119 0.2119
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.4078 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.1113 0.5251
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0019 0.0029
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0091 0.1591 0.4811
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.046 0.1129
Trypanosoma brucei unspecified product 0.0039 0.042 0.0628
Onchocerca volvulus 0.0031 0.026 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.026 0.0402
Loa Loa (eye worm) runx1 0.0059 0.0867 0.0867
Echinococcus multilocularis Protein lozenge 0.0059 0.0867 0.2125
Brugia malayi phosphofructokinase 0.0115 0.2119 0.2119
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0808 0.0808
Trypanosoma brucei DNA polymerase kappa, putative 0.0046 0.0575 0.0861
Loa Loa (eye worm) glutathione reductase 0.004 0.0448 0.0448
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0404 0.099
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0837 0.2052
Brugia malayi polk-prov protein 0.0045 0.0572 0.0572
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0019 0.0047
Echinococcus granulosus zinc finger protein 0.0021 0.0018 0.0044
Brugia malayi Pre-SET motif family protein 0.022 0.4464 0.4464
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0681 0.1051
Plasmodium falciparum thioredoxin reductase 0.004 0.0448 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.4078 1
Toxoplasma gondii hypothetical protein 0.0051 0.0705 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0249 0.0484
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.2119 0.3174
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0448 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0019 0.0019
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0837 0.0837
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0088 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0019 0.0019
Trypanosoma brucei DNA polymerase eta, putative 0.0083 0.1409 0.2109
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0572 0.0856
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0249 0.0484
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0101 0.1818 0.4297
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0249 0.3531
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0019
Schistosoma mansoni bromodomain containing protein 0.0067 0.1049 0.1617
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.1113 0.1667
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0662 0.0662
Toxoplasma gondii thioredoxin reductase 0.004 0.0448 0.6361
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0249 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Brugia malayi mbt repeat family protein 0.005 0.0681 0.0681
Onchocerca volvulus 0.005 0.0681 0.0664
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0963 0.1443
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0019 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0084 0.1435 0.2791
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.01 0.1425
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0448 0.1356
Schistosoma mansoni coup transcription factor 0.0021 0.0019 0.0029
Leishmania major DNA polymerase eta, putative 0.0044 0.0546 0.0817
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0101 0.1818 0.5497
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0837 0.2052
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0249 0.1175
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0448 0.0448
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.2119 0.4122
Schistosoma mansoni lozenge 0.0059 0.0867 0.1337
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0091 0.1591 0.4811
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.1435 0.2149
Leishmania major trypanothione reductase 0.004 0.0448 0.0672
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0019 0.0029

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) < 20 % Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells at 10 uM ChEMBL. 16279809
Activity (binding) < 20 % Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cells at 10 uM ChEMBL. 16279809
Activity (binding) = 27 % Displacement of [3H]SR141716A from human CB1 receptor expressed in CHO cells at 10 uM ChEMBL. 16279809
Activity (binding) = 27 % Displacement of [3H]SR141716A from human CB1 receptor expressed in CHO cells at 10 uM ChEMBL. 16279809
Ki (binding) 0 Displacement of [3H]SR141716A from human CB1 receptor expressed in CHO cells ChEMBL. 16279809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.