Detailed information for compound 427903

Basic information

Technical information
  • TDR Targets ID: 427903
  • Name: 4-[(4-bromo-3-hydroxyphenyl)methyl-(1,2,4-tri azol-4-yl)amino]benzonitrile
  • MW: 370.203 | Formula: C16H12BrN5O
  • H donors: 1 H acceptors: 4 LogP: 3.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)N(n1cnnc1)Cc1ccc(c(c1)O)Br
  • InChi: 1S/C16H12BrN5O/c17-15-6-3-13(7-16(15)23)9-22(21-10-19-20-11-21)14-4-1-12(8-18)2-5-14/h1-7,10-11,23H,9H2
  • InChiKey: WKQPRXJLBFKRFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(4-bromo-3-hydroxy-phenyl)methyl-(1,2,4-triazol-4-yl)amino]benzonitrile
  • 4-[(4-bromo-3-hydroxy-phenyl)methyl-(1,2,4-triazol-4-yl)amino]benzenecarbonitrile
  • 4-[(4-bromo-3-hydroxy-benzyl)-(1,2,4-triazol-4-yl)amino]benzonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 19, subfamily A, polypeptide 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi cytochrome P450, putative cytochrome P450, family 19, subfamily A, polypeptide 1 503 aa 425 aa 18.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0061 0.0208 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0732 0.2539
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.0581 0.1987
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0061 0.0208 0.07
Treponema pallidum phosphoglycolate phosphatase 0.0061 0.0208 0.1611
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0224 0.913
Echinococcus granulosus Solute carrier family 22 5 0.1099 0.4601 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.0732 0.2509
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0008 0.0002
Giardia lamblia Phosphoglycolate phosphatase 0.0061 0.0208 0.1611
Loa Loa (eye worm) hypothetical protein 0.0113 0.0427 0.1458
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.007 0.0224
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0107 0.4983
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0069 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0046
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0102 0.0102
Schistosoma mansoni integrin alpha-ps 0.0035 0.0096 0.0314
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0102 0.0337
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0019
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0201 0.0284
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0061 0.0208 0.0704
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0153 0.1153
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0245 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0008 0.0097
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0115 0.4557
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0122 0.04
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0102 0.403
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0069 0.0241 0.4003
Mycobacterium ulcerans hypothetical protein 0.0065 0.0224 0.0218
Brugia malayi Thioredoxin reductase 0.0039 0.0115 0.0377
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0102 0.0767
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0102 0.0767
Brugia malayi hypothetical protein 0.005 0.0161 0.0535
Leishmania major hypothetical protein, conserved 0.0036 0.0102 0.403
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0102 0.0333
Mycobacterium ulcerans hypothetical protein 0.0065 0.0224 0.0218
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0008 0.0097
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0093 0.0093
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.0371 0.0371
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0161 0.7094
Toxoplasma gondii exonuclease III APE 0.0037 0.0107 0.4621
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0172 0.0575
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0044 0.0082
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0153 0.0147
Schistosoma mansoni hypothetical protein 0.0689 0.2864 1
Plasmodium vivax glutathione reductase, putative 0.0039 0.0115 0.4992
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0131
Loa Loa (eye worm) RNA binding protein 0.0061 0.0208 0.0703
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0072 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0072 0.023
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0008 0.0008
Plasmodium vivax haloacid dehalogenase-like hydrolase, putative 0.0061 0.0208 0.9273
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) 0.0065 0.0224 0.0224
Brugia malayi beta-lactamase family protein 0.0036 0.0102 0.0333
Mycobacterium leprae Probable hydrolase 0.0061 0.0208 0.3438
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0328 0.0328
Mycobacterium tuberculosis Conserved protein 0.0065 0.0224 0.0224
Trypanosoma cruzi hydrolase-like protein, putative 0.0065 0.0224 0.913
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0008 0.0008
Plasmodium falciparum alpha/beta hydrolase, putative 0.0065 0.0224 1
Echinococcus multilocularis lamin dm0 0.0029 0.007 0.0093
Schistosoma mansoni ap endonuclease 0.0037 0.0107 0.0353
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0427 0.1454
Mycobacterium ulcerans lignin peroxidase LipJ 0.0065 0.0224 0.0218
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0008 0.0013
Mycobacterium tuberculosis Conserved protein 0.0036 0.0102 0.0102
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0008 0.0106
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0065 0.0224 0.1737
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0117 0.0444 0.1517
Echinococcus granulosus leukotriene A 4 hydrolase 0.0117 0.0444 0.0952
Onchocerca volvulus 0.0065 0.0224 0.0748
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0124 0.0922
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0008 0.0106
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0065 0.0224 0.1737
Brugia malayi TAR-binding protein 0.0061 0.0208 0.0698
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0334
Echinococcus multilocularis integrin alpha ps 0.0067 0.0232 0.0329
Mycobacterium tuberculosis Protein tyrosine kinase transcriptional regulatory protein PtkA 0.0061 0.0208 0.0208
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0328 0.0328
Brugia malayi hydrolase, alpha/beta fold family protein 0.0065 0.0224 0.0755
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0102 0.0096
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0107 0.0803
Mycobacterium tuberculosis Probable exported protease 0.0065 0.0224 0.0224
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.014 0.6134
Mycobacterium tuberculosis Possible epoxide hydrolase EphF (epoxide hydratase) (arene-oxide hydratase) 0.0065 0.0224 0.0224
Mycobacterium ulcerans beta-lactamase 0.0036 0.0102 0.0096
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0245 0.0836
Mycobacterium ulcerans epoxide hydrolase EphB 0.0065 0.0224 0.0218
Loa Loa (eye worm) hypothetical protein 0.005 0.0161 0.054
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0061 0.0208 0.0704
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.0208 0.0208
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.0097
Onchocerca volvulus Lipase homolog 0.0065 0.0224 0.0747
Schistosoma mansoni lamin 0.0029 0.007 0.0222
Echinococcus granulosus lamin dm0 0.0029 0.007 0.0138
Schistosoma mansoni hypothetical protein 0.0036 0.0101 0.0334
Onchocerca volvulus 0.0036 0.0102 0.0325
Loa Loa (eye worm) hypothetical protein 0.0036 0.0102 0.0338
Treponema pallidum phosphoglycolate phosphatase 0.0061 0.0208 0.1611
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Plasmodium falciparum glutathione reductase 0.0039 0.0115 0.4992
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0161 0.6477
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Mycobacterium tuberculosis Probable haloalkane dehalogenase 0.0065 0.0224 0.0224
Echinococcus multilocularis abhydrolase domain containing protein 0.0065 0.0224 0.0318
Plasmodium falciparum thioredoxin reductase 0.0039 0.0115 0.4992
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0122 0.0922
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.012 0.0166
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0101 0.436
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0093 0.0093
Giardia lamblia Fructose-bisphosphate aldolase 0.031 0.1262 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.007 0.0219
Plasmodium falciparum epoxide hydrolase 1 0.0065 0.0224 1
Echinococcus granulosus integrin alpha ps 0.0067 0.0232 0.0491
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0101 0.0101
Mycobacterium ulcerans exported protease 0.0065 0.0224 0.0218
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0101 0.4701
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0124 0.0938
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0122 0.5306
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0065 0.0224 0.1737
Brugia malayi hypothetical protein 0.0032 0.0085 0.0275
Echinococcus granulosus ephrin type A receptor 4 A 0.0066 0.0228 0.0482
Mycobacterium ulcerans haloalkane dehalogenase 0.0065 0.0224 0.0218
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0008 0.0097
Mycobacterium ulcerans hydrolase 0.0061 0.0208 0.0202
Onchocerca volvulus 0.0036 0.0102 0.0325
Toxoplasma gondii alpha/beta hydrolase, putative 0.0065 0.0224 1
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0208 0.0703
Trichomonas vaginalis hydrolase, putative 0.0065 0.0224 0.1737
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0072 0.301
Echinococcus granulosus abhydrolase domain containing protein 11 0.0065 0.0224 0.0475
Leishmania major histone deacetylase, putative 0.0041 0.0122 0.4844
Mycobacterium ulcerans lipase/esterase 0.0065 0.0224 0.0218
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium ulcerans hypothetical protein 0.0065 0.0224 0.0218
Schistosoma mansoni integrin alpha 0.0149 0.0581 0.201
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0008 0.0008
Echinococcus multilocularis GPCR, family 2 0.0017 0.0019 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0122 0.0922
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0008 0.0003
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0061 0.0208 0.1595
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0102 0.0102
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0245 0.0831
Loa Loa (eye worm) hypothetical protein 0.0029 0.007 0.0224
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0513
Loa Loa (eye worm) acetyltransferase 0.0154 0.06 0.2057
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0102 0.0102
Brugia malayi hydrolase, alpha/beta fold family protein 0.0065 0.0224 0.0755
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0061 0.0208 0.044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0513
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0334
Schistosoma mansoni hypothetical protein 0.0032 0.0084 0.0273
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0008 0.0002
Mycobacterium leprae POSSIBLE SECRETED PROTEASE 0.0065 0.0224 0.3711
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0061 0.0208 0.07
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0201 0.0423
Mycobacterium ulcerans hypothetical protein 0.0065 0.0224 0.0218
Entamoeba histolytica hypothetical protein 0.0061 0.0208 0.1595
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0224 0.913
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0107 0.4219
Leishmania major hypothetical protein, conserved 0.005 0.0161 0.6477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0013
Schistosoma mansoni choline dehydrogenase 0.0061 0.0208 0.0708
Mycobacterium ulcerans bromoperoxidase BpoC 0.0065 0.0224 0.0218
Leishmania major hypothetical protein, conserved 0.0065 0.0224 0.913
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0102 0.0767
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0107 0.4219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0732 0.2539
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0046
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0153 0.2484
Plasmodium falciparum acid cluster protein 33 homologue, putative 0.0065 0.0224 1
Brugia malayi UPF0017 protein CG3488 0.0065 0.0224 0.0755
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0117 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Loa Loa (eye worm) oxidoreductase 0.0014 0.0008 0.0013
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0153 0.6145
Mycobacterium ulcerans 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD 0.0065 0.0224 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0107 0.4219
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0147
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0115 0.0382
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) 0.0065 0.0224 0.3711
Mycobacterium ulcerans short chain dehydrogenase 0.0069 0.0241 0.0235
Mycobacterium ulcerans lipase/esterase 0.0065 0.0224 0.0218
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.0809 0.278
Echinococcus multilocularis abhydrolase domain containing protein 16A 0.0065 0.0224 0.0318
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Mycobacterium tuberculosis Conserved protein 0.0036 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0046
Leishmania major hydrolase-like protein,esterase-like protein 0.0065 0.0224 0.913
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0208 0.8467
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0008 0.0106
Mycobacterium ulcerans hypothetical protein 0.0048 0.0153 0.0147
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0122 0.0922
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0201 0.0673
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0124 0.5403
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0122 0.0922
Echinococcus multilocularis integrin alpha ps 0.0067 0.0232 0.0329
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0008 0.0106
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0107 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0208 0.0707
Mycobacterium tuberculosis Probable hydrolase 0.0061 0.0208 0.0208
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0061 0.0208 0.1595
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0102 0.1616
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0208 0.0707
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0256 0.0873
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0122 0.0922
Trypanosoma brucei histone deacetylase 1 0.0041 0.0122 0.4844
Brugia malayi MH2 domain containing protein 0.0124 0.0472 0.1612
Loa Loa (eye worm) hypothetical protein 0.0053 0.0172 0.058
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0102 0.0767
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0046
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0208 0.0703
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0224 1
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0122 0.0922
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0732 0.1579
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0117 0.0444 0.0638
Loa Loa (eye worm) hypothetical protein 0.0036 0.0102 0.0338
Entamoeba histolytica hypothetical protein 0.0061 0.0208 0.1595
Schistosoma mansoni hypothetical protein 0.0073 0.0256 0.0873
Loa Loa (eye worm) hypothetical protein 0.0065 0.0224 0.076
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0061 0.0208 0.0704
Schistosoma mansoni integrin alpha-ps 0.0067 0.0232 0.079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0732 0.1058
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0008 0.0008
Schistosoma mansoni family S33 non-peptidase homologue (S33 family) 0.0065 0.0224 0.0763
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0115 0.4992
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Brugia malayi beta-lactamase 0.0036 0.0102 0.0333
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0122 0.5306
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0007 0.0001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0107 0.0101
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0102 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0147
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0102 0.4414
Mycobacterium tuberculosis Possible haloalkane dehalogenase 0.0065 0.0224 0.0224
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0161 0.7094
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0061 0.0208 0.1595
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0107 0.4219
Trypanosoma cruzi hydrolase-like protein 0.0065 0.0224 0.913
Leishmania major hypothetical protein, conserved 0.0065 0.0224 0.913
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0093 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0208 0.0707
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0008 0.0008
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0122 0.0169
Onchocerca volvulus 0.0231 0.0928 0.3182
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Loa Loa (eye worm) haloacid dehalogenase-like hydrolase 0.0061 0.0208 0.0704
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Mycobacterium leprae Probable lipase LipE 0.0036 0.0102 0.1616
Brugia malayi alpha/beta hydrolase 0.0065 0.0224 0.0755
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.0371 0.0371
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0102 0.0337
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.1972
Loa Loa (eye worm) hypothetical protein 0.0036 0.0102 0.0338
Mycobacterium ulcerans haloalkane dehalogenase 0.0065 0.0224 0.0218
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Giardia lamblia Hydrolase, putative 0.0061 0.0208 0.1611
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.014 0.1066
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0328 0.5503
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0102 0.0102
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0008 0.0002
Leishmania major hydrolase, alpha/beta fold family, putative 0.0065 0.0224 0.913
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0117 0.0444 0.1531
Mycobacterium ulcerans peroxidase BpoB 0.0065 0.0224 0.0218
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0065 0.0224 0.913
Brugia malayi intermediate filament protein 0.0029 0.007 0.0219
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0201 0.0195
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0152 0.059 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0102 0.0767
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0122 0.0922
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0102 0.021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0019 0.0045
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0065 0.0224 0.913
Giardia lamblia Phosphoglycolate phosphatase 0.0061 0.0208 0.1611
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0102 0.014
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0153 0.1153
Mycobacterium leprae Probable exported protease 0.0065 0.0224 0.3711
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0508
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.0097
Echinococcus multilocularis geminin 0.0689 0.2864 0.4169
Schistosoma mansoni ap endonuclease 0.0037 0.0107 0.0353
Brugia malayi Pre-SET motif family protein 0.0029 0.0072 0.0227
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0117 0.0242
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0107 0.0803
Echinococcus multilocularis integrin alpha ps 0.0032 0.0084 0.0114
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0153 0.0147
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0208 0.0698
Loa Loa (eye worm) hypothetical protein 0.0041 0.0122 0.0405
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0061 0.0208 0.0295
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0008 0.0008
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0122 0.0169
Trypanosoma cruzi glycosyl hydrolase, putative 0.0061 0.0208 0.8467
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0508
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Trypanosoma brucei hydrolase, alpha/beta fold family, putative 0.0065 0.0224 0.913
Mycobacterium ulcerans exported protease 0.0065 0.0224 0.0218
Onchocerca volvulus 0.0018 0.0025 0.0059
Brugia malayi RNA binding protein 0.0061 0.0208 0.0698
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0008 0.0002
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0153 0.0147
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.0732 0.2513
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0224 1
Loa Loa (eye worm) abhydrolase domain-containing protein 2 0.0065 0.0224 0.0759
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0101 0.0095
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0224 0.0759
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0065 0.0224 0.1737
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0008 0.0013
Echinococcus multilocularis lamin 0.0029 0.007 0.0093
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0122 0.04
Schistosoma mansoni histone deacetylase 0.0041 0.0122 0.0405
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0508
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0153 0.6145
Echinococcus granulosus transcription factor Dp 1 0.0041 0.012 0.0248
Giardia lamblia Hydrolase, haloacid dehalogenase-like family 0.0061 0.0208 0.1611
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0019 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0072 0.023
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0019 0.0051
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0044 0.0055
Onchocerca volvulus 0.0029 0.0072 0.0219
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0007 0.0002
Trypanosoma cruzi hydrolase-like protein, putative 0.0065 0.0224 0.913
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0208 0.0707
Schistosoma mansoni lamin 0.0029 0.007 0.0222
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0061 0.0208 0.1595
Schistosoma mansoni intermediate filament proteins 0.0029 0.007 0.0222
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0008 0.0097
Echinococcus granulosus histone deacetylase 1 0.0041 0.0122 0.0252
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0122 0.4844
Echinococcus multilocularis musashi 0.0029 0.007 0.0093
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0008 0.0097
Giardia lamblia Histone deacetylase 0.0041 0.0122 0.0922
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.0371 0.0371
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0245 0.0826
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0065 0.0224 0.1737
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0245 0.1888
Leishmania major hydrolase-like protein 0.0065 0.0224 0.913
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0101 0.436
Onchocerca volvulus 0.0036 0.0102 0.0325
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0008 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0208 0.0295
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0152 0.059 0.0584
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0029
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0161 0.6477
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0107 0.0147
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.0732 0.1058
Toxoplasma gondii thioredoxin reductase 0.0039 0.0115 0.4992
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0061 0.0208 0.07
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0072 0.023
Trypanosoma brucei trypanothione reductase 0.0039 0.0115 0.4557
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0061 0.0208 0.0704
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Onchocerca volvulus 0.0048 0.0153 0.05
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium tuberculosis Probable oxidoreductase 0.0065 0.0224 0.0224
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0107 0.0354
Loa Loa (eye worm) hypothetical protein 0.0036 0.0102 0.0338
Mycobacterium tuberculosis Probable reductase 0.009 0.0328 0.0328
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0008 0.0002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1633 0.6861 1
Schistosoma mansoni histone deacetylase 0.0041 0.0122 0.0405
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0472 0.1617
Entamoeba histolytica alpha/beta hydrolase fold protein, putative 0.0065 0.0224 0.1722
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066 0.0228 0.0323
Loa Loa (eye worm) hypothetical protein 0.0017 0.0019 0.0051
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0008 0.0018
Wolbachia endosymbiont of Brugia malayi phosphatase 0.0061 0.0208 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0172 0.058
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.014 0.0291
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0153 0.2484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Entamoeba histolytica hypothetical protein 0.0065 0.0224 0.1722
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0334
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Echinococcus granulosus lamin 0.0029 0.007 0.0138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0102 0.0102
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0152 0.059 0.059
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0328 0.0328
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.06 0.2053
Brugia malayi Hypothetical 54.7 kDa protein F37A4.1 in chromosome III 0.0065 0.0224 0.0755
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.0371 0.6232
Leishmania major hydrolase-like protein,esterase-like protein 0.0065 0.0224 0.913
Schistosoma mansoni 2-deoxyglucose-6-phosphate phosphatase 0.0061 0.0208 0.0708
Mycobacterium ulcerans lipase LipD 0.0036 0.0102 0.0096
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0153 0.0153
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0061 0.0208 0.1595
Mycobacterium ulcerans oxidoreductase 0.0065 0.0224 0.0218
Onchocerca volvulus 0.0029 0.007 0.0212
Mycobacterium tuberculosis Probable homoserine O-acetyltransferase MetA (homoserine O-trans-acetylase) (homoserine transacetylase) (HTA) 0.0065 0.0224 0.0224
Loa Loa (eye worm) hydrolase 0.0065 0.0224 0.0759
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0065 0.0224 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0208 0.0707
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0102 0.0102
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Echinococcus multilocularis haloacid dehalogenase hydrolase 0.0061 0.0208 0.0295
Mycobacterium tuberculosis Possible phosphatase 0.0061 0.0208 0.0208
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.06 0.2078
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0013 0.0025
Echinococcus granulosus abhydrolase domain containing protein 3 0.0065 0.0224 0.0475
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0161 0.7094
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0122 0.0905
Toxoplasma gondii homoserine O-acetyltransferase, putative 0.0065 0.0224 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.0732 0.1579
Plasmodium vivax hypothetical protein, conserved 0.0065 0.0224 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0245 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Schistosoma mansoni hypothetical protein 0.0689 0.2864 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0245 0.0349
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0102 0.0338
Mycobacterium tuberculosis Probable carboxylesterase CaeA 0.0065 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0014 0.0008 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0256 0.0543
Onchocerca volvulus Phospholipase A2 homolog 0.0279 0.1129 0.388
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0334
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0008
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0065 0.0224 0.1737
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0201 0.0201
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0061 0.0208 0.1595
Echinococcus granulosus histone deacetylase 3 0.0041 0.0122 0.0252
Mycobacterium ulcerans epoxide hydrolase EphE 0.0065 0.0224 0.0218
Brugia malayi Histone deacetylase 1 0.0041 0.0122 0.04
Brugia malayi glutathione reductase 0.0039 0.0115 0.0377
Onchocerca volvulus Lipase homolog 0.0065 0.0224 0.0747
Loa Loa (eye worm) beta-lactamase 0.0036 0.0102 0.0338
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0256 0.0364
Mycobacterium ulcerans epoxide hydrolase EphA 0.2375 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0019 0.0019
Leishmania major histone deacetylase, putative 0.0041 0.0122 0.4844
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0008 0.0008
Echinococcus granulosus GPCR family 2 0.0017 0.0019 0.0029
Echinococcus granulosus histone acetyltransferase KAT2B 0.015 0.0582 0.1252
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.014 0.6134
Loa Loa (eye worm) hypothetical protein 0.0028 0.0067 0.0217
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0061 0.0208 0.1595
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Echinococcus granulosus geminin 0.0689 0.2864 0.6219
Loa Loa (eye worm) hypothetical protein 0.0033 0.0089 0.0291
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0201 0.814
Loa Loa (eye worm) integrin alpha pat-2 0.023 0.0923 0.3174
Entamoeba histolytica haloacid dehalogenase-like hydrolase domain-containing protein 0.0061 0.0208 0.1595
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0013 0.003
Mycobacterium leprae Probable exported protease 0.0065 0.0224 0.3711
Mycobacterium tuberculosis Conserved protein 0.0036 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0065 0.0224 0.0759
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0102 0.0102
Entamoeba histolytica HAD hydrolase, family IA, variant 3 0.0061 0.0208 0.1595
Mycobacterium ulcerans hydrolase 0.0061 0.0208 0.0202
Echinococcus granulosus intermediate filament protein 0.0029 0.007 0.0138
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0067 0.0133
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0093 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.031 0.1262 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0065 0.0224 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0122 0.4844
Loa Loa (eye worm) hypothetical protein 0.0061 0.0208 0.0704
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0107 0.0803
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0008 0.0008
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0122 0.0405
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Loa Loa (eye worm) hypothetical protein 0.0697 0.2898 1
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.1972
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0107 0.0349
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0072 0.0143
Toxoplasma gondii ABC1 family protein 0.0036 0.0102 0.4414
Trypanosoma cruzi hypothetical protein, conserved 0.0065 0.0224 0.913
Echinococcus granulosus integrin alpha ps 0.0032 0.0084 0.017
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0201 0.0195
Loa Loa (eye worm) glutathione reductase 0.0039 0.0115 0.0382
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.014 0.6134
Echinococcus multilocularis abhydrolase domain containing protein 11 0.0065 0.0224 0.0318
Brugia malayi ephrin receptor 1 precursor 0.0031 0.0082 0.0261
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0122 0.0922
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0072 0.023
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0008 0.0008
Echinococcus multilocularis abhydrolase domain containing 3 0.0065 0.0224 0.0318
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0072 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0334
Brugia malayi hypothetical protein 0.0105 0.0392 0.1335
Mycobacterium ulcerans non-heme haloperoxidase Hpx 0.0065 0.0224 0.0218
Loa Loa (eye worm) hypothetical protein 0.0117 0.0445 0.1521
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.06 0.0866
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.1972
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0172 0.0575
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.014 0.1066
Mycobacterium ulcerans homoserine O-acetyltransferase 0.0065 0.0224 0.0218
Giardia lamblia ENC6 protein 0.0065 0.0224 0.1737
Echinococcus granulosus tar DNA binding protein 0.0061 0.0208 0.0439
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Echinococcus granulosus abhydrolase domain containing protein 0.0065 0.0224 0.0475
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0107 0.4621
Mycobacterium tuberculosis Possible peroxidase BpoB (non-haem peroxidase) 0.0065 0.0224 0.0224
Mycobacterium ulcerans proline iminopeptidase PIP 0.0065 0.0224 0.0218
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0245 1
Mycobacterium ulcerans hypothetical protein 0.0061 0.0208 0.0202
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0513
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.1262 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0297 0.1011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0153 0.0153
Plasmodium falciparum haloacid dehalogenase-like hydrolase, putative 0.0061 0.0208 0.9273
Loa Loa (eye worm) TK/EPH protein kinase 0.0084 0.0303 0.1032
Loa Loa (eye worm) hypothetical protein 0.0279 0.1129 0.3888
Entamoeba histolytica hypothetical protein 0.0073 0.0256 0.1972
Loa Loa (eye worm) intermediate filament protein 0.0029 0.007 0.0224
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0201 0.0681
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.0097
Mycobacterium leprae Probable homoserine o-acetyltransferase MetA 0.0065 0.0224 0.3711
Echinococcus granulosus lysosomal acid lipase:cholesteryl ester 0.0065 0.0224 0.0475
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0184 0.0619
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0065 0.0224 0.0747
Brugia malayi hypothetical protein 0.0073 0.0256 0.0863
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0008 0.0097
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0008 0.0106
Schistosoma mansoni ephrin receptor 0.0066 0.0228 0.0775
Echinococcus multilocularis abhydrolase domain containing protein 3 0.0065 0.0224 0.0318
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 3 containing protein 0.0061 0.0208 0.07
Mycobacterium ulcerans hydrolase 0.0065 0.0224 0.0218
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0019 0.0045
Echinococcus multilocularis lysosomal acid lipase:cholesteryl ester 0.0065 0.0224 0.0318
Onchocerca volvulus 0.0061 0.0208 0.0692
Onchocerca volvulus 0.0061 0.0208 0.0692
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Brugia malayi HAD-superfamily hydrolase, subfamily IA, variant 1 containing protein 0.0061 0.0208 0.07
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0014 0.0006 0.0006
Trichomonas vaginalis set domain proteins, putative 0.0231 0.0928 0.7338
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0096 0.0316
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0122 0.5306
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0072 0.0096
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0008 0.0008
Leishmania major serine peptidase, putative,serine peptidase, Clan SC, Family S9D 0.0065 0.0224 0.913
Treponema pallidum fructose-bisphosphate aldolase 0.031 0.1262 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0072 0.301
Mycobacterium ulcerans epoxide hydrolase EphF 0.0065 0.0224 0.0218
Loa Loa (eye worm) hypothetical protein 0.0032 0.0084 0.0275
Trichomonas vaginalis esterase, putative 0.0036 0.0102 0.0767
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0008 0.0002
Loa Loa (eye worm) HAD-superfamily hydrolase 0.0061 0.0208 0.0704
Mycobacterium ulcerans hydrolase 0.0065 0.0224 0.0218
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0161 0.6477
Brugia malayi Alpha/beta hydrolase 0.0065 0.0224 0.0755
Loa Loa (eye worm) hypothetical protein 0.0036 0.0102 0.0338
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0122 0.0405
Leishmania major hydrolase, alpha/beta fold family-like protein 0.0065 0.0224 0.913
Loa Loa (eye worm) ab-hydrolase associated lipase region family protein 0.0065 0.0224 0.0759
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0245 0.052
Leishmania major trypanothione reductase 0.0039 0.0115 0.4557
Mycobacterium ulcerans hypothetical protein 0.0036 0.0102 0.0096
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0122 0.0922
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0472 0.1617
Brugia malayi Pre-SET motif family protein 0.0203 0.0809 0.2776
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0208 0.1611
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0107 0.0803
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0008 0.0008
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0102 0.403
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0115 0.0115
Brugia malayi beta-lactamase family protein 0.0036 0.0102 0.0333
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.0732 0.2539
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0107 0.0786
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0008 0.0018
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0008 0.0002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0107 0.4621
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0153 0.1153
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0161 0.7094
Entamoeba histolytica alpha/beta hydrolase domain protein, putative 0.0065 0.0224 0.1722
Echinococcus multilocularis integrin alpha 3 0.0115 0.0433 0.0623
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0065 0.0224 0.1737
Loa Loa (eye worm) hypothetical protein 0.0036 0.0102 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0102 0.403
Chlamydia trachomatis phosphoglycolate phosphatase 0.0061 0.0208 1
Brugia malayi Phospholipase A2 family protein 0.0697 0.2898 1
Onchocerca volvulus Phospholipase A2 homolog 0.0697 0.2898 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0008
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0153 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0153 0.6145
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0008 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0008 0.0008
Echinococcus granulosus haloacid dehalogenase hydrolase 0.0061 0.0208 0.044
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0107 0.0219
Onchocerca volvulus 0.0029 0.007 0.0212
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0233 0.0227
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0061 0.0208 0.07
Loa Loa (eye worm) hypothetical protein 0.0036 0.0101 0.0335
Echinococcus granulosus integrin alpha 3 0.0115 0.0433 0.0929
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0147
Plasmodium falciparum histone deacetylase 1 0.0041 0.0122 0.5306
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.0933 0.0933
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0065 0.0224 0.0224
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0008 0.0005
Trichomonas vaginalis 2-deoxyglucose-6-phosphate phosphatase, putative 0.0061 0.0208 0.1611
Schistosoma mansoni hydrolase 0.0065 0.0224 0.0763
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.031 0.1262 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0328 0.0328
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0101 0.033

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.5 nM Inhibition of aromatase in JEG3 cell membrane ChEMBL. 17580845
IC50 (binding) = 0.5 nM Inhibition of aromatase in JEG3 cell membrane ChEMBL. 17580845

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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