Detailed information for compound 431534

Basic information

Technical information
  • TDR Targets ID: 431534
  • Name: 2-[[2-(3-fluoro-4-methylanilino)pyrimidin-4-y l]amino]benzoic acid
  • MW: 338.336 | Formula: C18H15FN4O2
  • H donors: 3 H acceptors: 4 LogP: 4.5 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccccc1Nc1ccnc(n1)Nc1ccc(c(c1)F)C
  • InChi: 1S/C18H15FN4O2/c1-11-6-7-12(10-14(11)19)21-18-20-9-8-16(23-18)22-15-5-3-2-4-13(15)17(24)25/h2-10H,1H3,(H,24,25)(H2,20,21,22,23)
  • InChiKey: BQWUBCRDJPIJAT-UHFFFAOYSA-N  


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Synonyms

  • 2-[[2-(3-fluoro-4-methyl-anilino)pyrimidin-4-yl]amino]benzoic acid
  • 2-[[2-(3-fluoro-4-methylanilino)-4-pyrimidinyl]amino]benzoic acid
  • 2-[[2-[(3-fluoro-4-methyl-phenyl)amino]pyrimidin-4-yl]amino]benzoic acid
  • 2-[[2-[(3-fluoro-4-methylphenyl)amino]pyrimidin-4-yl]amino]benzoic acid
  • 2-[[2-[(3-fluoro-4-methylphenyl)amino]-4-pyrimidinyl]amino]benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens MAP kinase interacting serine/threonine kinase 2 Starlite/ChEMBL No references
Homo sapiens aurora kinase B Starlite/ChEMBL No references
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens aurora kinase A Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens mitogen-activated protein kinase 8 Starlite/ChEMBL References
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing Get druggable targets OG5_129677 All targets in OG5_129677
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis c Jun NH2 terminal kinase Get druggable targets OG5_129677 All targets in OG5_129677
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Stress-activated protein kinase jnk-1 Get druggable targets OG5_129677 All targets in OG5_129677
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus c-Jun N-terminal kinases Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131958 All targets in OG5_131958
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase Get druggable targets OG5_131958 All targets in OG5_131958
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04440 c-Jun N-terminal kinase, putative Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Trypanosoma brucei mitogen-activated protein kinase 5 aurora kinase B 303 aa 299 aa 22.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0198 0.284 0.6205
Schistosoma mansoni serine/threonine protein kinase 0.0198 0.284 0.6205
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0141 0.1691 0.3695
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0079 0.0423 0.2502
Plasmodium falciparum protein serine/threonine kinase-1 0.0079 0.0423 0.2502
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0552 1 1
Echinococcus granulosus protein kinase 0.0078 0.0417 0.0911
Schistosoma mansoni protein kinase 0.0109 0.103 0.2251
Brugia malayi Protein kinase domain containing protein 0.0505 0.9055 0.9055
Brugia malayi Stress-activated protein kinase jnk-1 0.0284 0.4577 0.4577
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.2507 0.5476
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0064 0.012 0.0709
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0505 0.9055 0.9055
Schistosoma mansoni serine/threonine protein kinase 0.0284 0.4577 1
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0284 0.4577 0.4577
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0284 0.4577 1
Brugia malayi probable protein kinase 0.0109 0.103 0.103
Echinococcus multilocularis rho associated protein kinase 0.0182 0.2507 0.5476
Trichomonas vaginalis AGC family protein kinase 0.0141 0.1691 1
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.012 0.0389
Trichomonas vaginalis AGC family protein kinase 0.0141 0.1691 1
Giardia lamblia Kinase, CMGC GSK 0.0064 0.012 0.0709
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0198 0.284 0.284
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.012 0.012
Entamoeba histolytica protein kinase domain containing protein 0.021 0.308 1
Entamoeba histolytica protein kinase domain containing protein 0.0141 0.1691 0.5492
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0064 0.012 0.0709
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0079 0.0423 0.2502
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0064 0.012 0.0709
Leishmania major protein kinase, putative 0.0079 0.0423 0.2502
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0141 0.1691 0.5492
Loa Loa (eye worm) hypothetical protein 0.0102 0.0903 0.0903
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0198 0.284 0.284
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0079 0.0423 0.2502
Echinococcus granulosus aurora kinase A 0.0141 0.1691 0.3695
Loa Loa (eye worm) hypothetical protein 0.0072 0.0296 0.0296
Giardia lamblia Kinase, CMGC CLK 0.0079 0.0423 0.2502
Brugia malayi serine/threonine protein kinase 6 0.0141 0.1691 0.1691
Brugia malayi Protein kinase domain containing protein 0.0198 0.284 0.284
Trypanosoma brucei aurora B kinase 0.0141 0.1691 1
Entamoeba histolytica protein kinase , putative 0.0141 0.1691 0.5492
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0078 0.0417 0.0417
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0064 0.012 0.0262
Echinococcus multilocularis 0.0072 0.0296 0.0646
Leishmania major protein kinase, putative 0.0141 0.1691 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0141 0.1691 0.5492
Echinococcus granulosus dual specificity protein kinase clk2 0.0079 0.0423 0.0925
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0064 0.012 0.012
Trichomonas vaginalis AGC family protein kinase 0.0141 0.1691 1
Echinococcus granulosus c-Jun N-terminal kinases 0.0284 0.4577 1
Brugia malayi serine/threonine kinase 12 0.0141 0.1691 0.1691
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0141 0.1691 0.3695
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0079 0.0423 0.2502
Onchocerca volvulus 0.0175 0.2379 0.8305
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0423 0.0925
Echinococcus granulosus homeodomain interacting protein kinase 3 0.021 0.308 0.6728
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0064 0.012 0.0262
Loa Loa (eye worm) AUR protein kinase 0.0141 0.1691 0.1691
Giardia lamblia Kinase, CMGC GSK 0.0064 0.012 0.0709
Echinococcus multilocularis 0.0078 0.0417 0.0911
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0198 0.284 1
Entamoeba histolytica protein kinase, putative 0.0064 0.012 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.0079 0.0423 0.0925
Echinococcus multilocularis dual specificity protein kinase clk2 0.0079 0.0423 0.0925
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0079 0.0423 0.2502
Leishmania major protein kinase, putative 0.0079 0.0423 0.2502
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.012 0.0709
Entamoeba histolytica protein kinase, putative 0.0141 0.1691 0.5492
Trichomonas vaginalis CMGC family protein kinase 0.0064 0.012 0.0709
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0141 0.1691 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0141 0.1691 1
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.021 0.308 0.6728
Giardia lamblia Aurora kinase 0.0141 0.1691 1
Echinococcus multilocularis protein kinase shaggy 0.0064 0.012 0.0262
Brugia malayi Protein kinase domain containing protein 0.0079 0.0423 0.0423
Echinococcus granulosus protein kinase shaggy 0.0064 0.012 0.0262
Plasmodium vivax serine/threonine kinase-1, putative 0.0079 0.0423 0.2502
Onchocerca volvulus 0.0182 0.2507 0.8775
Brugia malayi Homeodomain interacting protein kinase protein 1 0.021 0.308 0.308
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0064 0.012 0.0262
Toxoplasma gondii aurora kinase 0.0141 0.1691 1
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0198 0.284 0.6205
Trypanosoma cruzi aurora B kinase, putative 0.0141 0.1691 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0141 0.1691 0.5492
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0423 0.2502
Echinococcus granulosus rho-associated protein kinase 1 0.0182 0.2507 0.5476
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0198 0.284 0.284
Plasmodium falciparum glycogen synthase kinase 3 0.0064 0.012 0.0709
Loa Loa (eye worm) AUR protein kinase 0.0141 0.1691 0.1691
Loa Loa (eye worm) AUR protein kinase 0.0141 0.1691 0.1691
Schistosoma mansoni serine/threonine protein kinase 0.021 0.308 0.6728
Trypanosoma brucei protein kinase, putative 0.0064 0.012 0.0709
Schistosoma mansoni protein kinase 0.0141 0.1691 0.3695
Echinococcus multilocularis aurora kinase A 0.0141 0.1691 0.3695
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0079 0.0423 0.0423
Trichomonas vaginalis AGC family protein kinase 0.0141 0.1691 1
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0079 0.0423 0.2502
Entamoeba histolytica protein kinase domain containing protein 0.0064 0.012 0.0389
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.021 0.308 0.308
Brugia malayi serine/threonine-protein kinase 6 0.0141 0.1691 0.1691
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.1691 0.3695
Entamoeba histolytica protein kinase, putative 0.0141 0.1691 0.5492
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.0903 0.1972
Brugia malayi intracellular kinase 0.0064 0.012 0.012
Schistosoma mansoni protein kinase 0.0078 0.0417 0.0911
Echinococcus granulosus hypothetical protein 0.0072 0.0296 0.0646
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0079 0.0423 0.2502
Plasmodium vivax glycogen synthase kinase 3, putative 0.0064 0.012 0.0709

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 93 nM Inhibition at human JNK1 at 1uM ChEMBL. 17107797
IC50 (binding) = 93 nM Inhibition at human JNK1 at 1uM ChEMBL. 17107797
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 5.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) = 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) = 6.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MKNK2 ChEMBL. No reference
Ki (functional) = 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 6.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) = 7.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (functional) = 7.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 ChEMBL. No reference
Ki (functional) = 8.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 8.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK12 ChEMBL. No reference
Ki (functional) = 8.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.