Detailed information for compound 433503

Basic information

Technical information
  • TDR Targets ID: 433503
  • Name: N-[4-chloro-3-[(4-methylpiperazin-1-yl)methyl ]phenyl]-6-[2-(methylamino)pyrimidin-4-yl]oxy -1H-benzimidazol-2-amine
  • MW: 478.977 | Formula: C24H27ClN8O
  • H donors: 3 H acceptors: 3 LogP: 4.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1nccc(n1)Oc1ccc2c(c1)nc([nH]2)Nc1ccc(c(c1)CN1CCN(CC1)C)Cl
  • InChi: 1S/C24H27ClN8O/c1-26-23-27-8-7-22(31-23)34-18-4-6-20-21(14-18)30-24(29-20)28-17-3-5-19(25)16(13-17)15-33-11-9-32(2)10-12-33/h3-8,13-14H,9-12,15H2,1-2H3,(H,26,27,31)(H2,28,29,30)
  • InChiKey: WNVCGTBXTUKEAE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[4-chloro-3-[(4-methyl-1-piperazinyl)methyl]phenyl]-6-[[2-(methylamino)-4-pyrimidinyl]oxy]-1H-benzimidazol-2-amine
  • [4-[[2-[4-chloro-3-[(4-methylpiperazino)methyl]anilino]-3H-benzimidazol-5-yl]oxy]pyrimidin-2-yl]-methyl-amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA binding protein 0.0064 0.0158 0.1346
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0042 0.0089 0.4243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Brugia malayi TAR-binding protein 0.0064 0.0158 0.1294
Schistosoma mansoni lamin 0.0031 0.0053 0.0472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0089 0.0562
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0086 0.0913
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0055 0.0129 0.0127
Brugia malayi Probable ClpP-like protease 0.0074 0.019 0.157
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0074 0.019 0.0188
Brugia malayi intermediate filament protein 0.0031 0.0053 0.0392
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0667 0.5664
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0221 0.0654 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0082 0.0214 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0082 0.0214 0.1507
Echinococcus multilocularis lamin 0.0031 0.0053 0.0051
Echinococcus granulosus neuropeptide s receptor 0.0415 0.1272 0.127
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0139 0.0394 0.5934
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0063 0.0141
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0074 0.019 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0221 0.0654 0.0652
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0121 0.0119
Onchocerca volvulus 0.0041 0.0086 0.0256
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0731
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0002
Mycobacterium tuberculosis Probable reductase 0.0125 0.0351 0.4314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0221 0.0654 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0042 0.0089 0.4243
Loa Loa (eye worm) hypothetical protein 0.0033 0.006 0.0514
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Echinococcus multilocularis peptidase Clp (S14 family) 0.0049 0.0109 0.0107
Schistosoma mansoni hypothetical protein 0.0042 0.0089 0.0806
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0351 0.8769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0089 0.0562
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0221 0.0654 0.0653
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0351 0.4314
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0042 0.0089 0.1164
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0089 0.4243
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Echinococcus granulosus lamin 0.0031 0.0053 0.0051
Echinococcus granulosus neutral alpha glucosidase AB 0.0034 0.0063 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0089 0.0216
Trichomonas vaginalis maltase-glucoamylase, putative 0.0034 0.0063 0.0368
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0434
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0096 0.0259 0.0258
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.1161
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0086 0.0537
Mycobacterium leprae Probable lipase LipE 0.0041 0.0086 0.1396
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0042 0.0089 0.0806
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0015 0.0011
Plasmodium vivax hypothetical protein 0.0042 0.0089 0.4243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0063 0.0368
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0731
Schistosoma mansoni hypothetical protein 0.003 0.0051 0.0456
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0089 0.0759
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.0495 0.3438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Echinococcus multilocularis musashi 0.0031 0.0053 0.0051
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0042 0.0089 0.0562
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0221 0.0654 0.1783
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0086 0.0913
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0042 0.0089 0.0087
Giardia lamblia Phosphatidylinositol 4-kinase 0.0042 0.0089 0.1164
Trypanosoma cruzi hypothetical protein, conserved 0.0034 0.0063 0.0141
Brugia malayi Calcitonin receptor-like protein seb-1 0.0045 0.0096 0.0762
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0124 0.0349 0.0347
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0158 0.1346
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0042 0.0089 0.0087
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0089 0.0759
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0089 0.0703
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0042 0.0089 0.0216
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0063 0.0368
Echinococcus multilocularis neutral alpha glucosidase AB 0.0034 0.0063 0.0061
Schistosoma mansoni alpha-glucosidase 0.0133 0.0377 0.3464
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0089 0.1164
Plasmodium vivax glutathione reductase, putative 0.0055 0.0128 0.6469
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0042 0.0089 0.0216
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0155 0.0445 0.3799
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0221 0.0654 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0129 0.1176
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0759
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0534 0.4519
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0086 0.1113
Onchocerca volvulus 0.0437 0.134 1
Echinococcus granulosus peptidase Clp S14 family 0.0049 0.0109 0.0107
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0042 0.0089 0.1161
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0042 0.0089 0.0562
Trypanosoma cruzi target of rapamycin kinase 3 0.0221 0.0654 0.1852
Echinococcus granulosus snurportin 1 0.0356 0.1085 0.1084
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0086 0.0206
Loa Loa (eye worm) phosphatidylinositol 3 0.0221 0.0654 0.5581
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Brugia malayi Glycosyl hydrolases family 31 protein 0.0155 0.0445 0.3762
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0089 0.0208
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0015 0.0003
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0089 0.0562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0121 0.1104
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0051 0.0378
Loa Loa (eye worm) hypothetical protein 0.0124 0.0349 0.2978
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Echinococcus multilocularis Zinc finger, PHD finger 0.0042 0.0089 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0001
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0129 0.0127
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0124 0.0349 0.2935
Toxoplasma gondii ABC1 family protein 0.0041 0.0086 0.1113
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0086 0.0675
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.1161
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Schistosoma mansoni alpha-glucosidase 0.0133 0.0377 0.3464
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0063 0.0368
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0063 0.0759
Trichomonas vaginalis conserved hypothetical protein 0.0139 0.0394 0.2863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0221 0.0654 0.5554
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0351 0.4314
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0089 0.0956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0049 0.0109 0.204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0042 0.0089 0.1164
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0128 0.6469
Schistosoma mansoni hypothetical protein 0.0096 0.0259 0.238
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.1164
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0356 0.1085 0.9258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0124 0.0349 0.2935
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0019 0.0015 0.0064
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0158 0.1441
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0124 0.0349 0.3206
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0015 0.0003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0086 0.0731
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.0089 0.0806
Plasmodium falciparum thioredoxin reductase 0.0055 0.0128 0.6469
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0013
Trichomonas vaginalis sucrase-isomaltase, putative 0.0034 0.0063 0.0368
Leishmania major phosphatidylinositol kinase related protein, putative 0.0042 0.0089 0.0208
Entamoeba histolytica hypothetical protein 0.0042 0.0089 0.1161
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0086 0.0537
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0089 0.0759
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0086 0.4055
Echinococcus multilocularis neuropeptide s receptor 0.0415 0.1272 0.127
Echinococcus multilocularis lamin dm0 0.0031 0.0053 0.0051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0089 0.0703
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0089 0.0703
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0139 0.0394 0.2863
Toxoplasma gondii hypothetical protein 0.0026 0.0036 0.0328
Loa Loa (eye worm) hypothetical protein 0.0055 0.0129 0.11
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0089 0.0759
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0667 0.569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0121 0.012
Mycobacterium tuberculosis Conserved protein 0.0041 0.0086 0.0913
Leishmania major phosphatidylinositol 3-kinase, putative 0.0221 0.0654 0.1783
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0435
Schistosoma mansoni importin beta-1 0.0033 0.006 0.0541
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0139 0.0394 0.5934
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Brugia malayi RNA, U transporter 1 0.0095 0.0256 0.2133
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0214 0.1507
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0129 0.1176
Schistosoma mansoni hypothetical protein 0.0356 0.1085 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0014
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0042 0.0089 0.0087
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0089 0.0216
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0731
Mycobacterium tuberculosis Conserved protein 0.0041 0.0086 0.0913
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0221 0.0654 0.6023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Echinococcus granulosus tar DNA binding protein 0.0064 0.0158 0.0156
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0221 0.0654 0.1852
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.006 0.0715
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.0042 0.0089 0.0759
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0042 0.0089 0.0759
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.004 0.0074
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0086 0.0537
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0351 0.4314
Brugia malayi Thioredoxin reductase 0.0055 0.0128 0.1038
Brugia malayi beta-lactamase family protein 0.0041 0.0086 0.0675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Leishmania major hypothetical protein, unknown function 0.0042 0.0089 0.0208
Leishmania major hypothetical protein, conserved 0.115 0.3602 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0089 0.1164
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0013
Schistosoma mansoni alpha glucosidase 0.0034 0.0063 0.0569
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0096 0.0259 0.0258
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0089 0.0703
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Loa Loa (eye worm) hypothetical protein 0.0074 0.019 0.1621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Plasmodium vivax SET domain protein, putative 0.0055 0.0129 0.6524
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0042 0.0089 0.0216
Loa Loa (eye worm) glutathione reductase 0.0055 0.0128 0.1092
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.004 0.0194
Schistosoma mansoni lamin 0.0031 0.0053 0.0472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0089 0.0562
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0089 0.0087
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0015
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.0089 0.4243
Brugia malayi beta-lactamase 0.0041 0.0086 0.0675
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0034 0.0063 0.0759
Onchocerca volvulus 0.009 0.0238 0.1441
Loa Loa (eye worm) phosphatidylinositol kinase 0.0042 0.0089 0.0759
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Echinococcus multilocularis snurportin 1 0.0356 0.1085 0.1084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0086 0.0084
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0053 0.0392
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0351 0.4314
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0019 0.0015 0.0119
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0086 0.4055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0007 0.006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.4243
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0042 0.0089 0.1164
Entamoeba histolytica hypothetical protein 0.0042 0.0089 0.1161
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0121 0.0119
Onchocerca volvulus 0.0041 0.0086 0.0256
Echinococcus granulosus serine protein kinase ATM 0.0124 0.0349 0.0347
Echinococcus multilocularis roundabout 2 0.0018 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0096 0.0817
Leishmania major importin beta-1 subunit, putative 0.0027 0.004 0.0072
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0089 0.1488
Leishmania major phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.0208
Echinococcus multilocularis importin subunit beta 1 0.0033 0.006 0.0058
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0034 0.0063 0.0762
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0086 0.4055
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0086 0.0537
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0351 0.4314
Echinococcus granulosus importin subunit beta 1 0.0033 0.006 0.0059
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.4243
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.0089 0.4243
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0158 0.1294
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0121
Echinococcus granulosus neuropeptide receptor A26 0.0415 0.1272 0.127
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.006 0.0715
Onchocerca volvulus 0.0167 0.0483 0.3342
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0055 0.0129 0.179
Trypanosoma brucei trypanothione reductase 0.0055 0.0128 0.1775
Toxoplasma gondii exonuclease III APE 0.0019 0.0015 0.0003
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0128 0.0126
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.0216
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0221 0.0654 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.0089 0.0806
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0089 0.0087
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0221 0.0654 0.1852
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0053 0.045
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0074 0.019 0.43
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0221 0.0654 0.5554
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0089 0.0806
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0036 0.1197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0086 0.0913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Loa Loa (eye worm) hypothetical protein 0.0096 0.0259 0.2214
Echinococcus multilocularis lysosomal alpha glucosidase 0.0155 0.0445 0.0444
Brugia malayi Pre-SET motif family protein 0.0055 0.0129 0.1047
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0042 0.0089 0.0703
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0221 0.0654 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0089 0.0703
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0074 0.019 0.2743
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0158 0.0156
Trichomonas vaginalis set domain proteins, putative 0.0437 0.134 1
Brugia malayi FAT domain containing protein 0.0096 0.0259 0.2167
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.004 0.0194
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0086 0.1396
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0158 0.1441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Onchocerca volvulus 0.0055 0.0129 0.0592
Leishmania major phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.0208
Loa Loa (eye worm) beta-lactamase 0.0041 0.0086 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0015 0.0011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0089 0.0216
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0158 0.1441
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0045 0.0096 0.0762
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0221 0.0654 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0042 0.0089 0.1161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0121 0.1034
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0063 0.0368
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0074 0.019 0.0188
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0063 0.0368
Echinococcus granulosus lamin dm0 0.0031 0.0053 0.0051
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0089 0.1164
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0053 0.045
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.006 0.0715
Trypanosoma cruzi hypothetical protein, conserved 0.1107 0.3468 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0086 0.0913
Echinococcus multilocularis neuropeptide receptor A26 0.0415 0.1272 0.127
Leishmania major phosphatidylinositol kinase, putative 0.0042 0.0089 0.0208
Echinococcus multilocularis 0.0042 0.0089 0.0087
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0015 0.0011
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0124 0.0349 0.0969
Giardia lamblia GTOR 0.0221 0.0654 1
Entamoeba histolytica hypothetical protein 0.0027 0.004 0.0399
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0086 0.0084
Plasmodium vivax importin-beta 2, putative 0.0033 0.006 0.2606
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.0011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.0794 1
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0259 0.1847
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0124 0.0349 0.0969
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Loa Loa (eye worm) phosphatidylinositol 3 0.0221 0.0654 0.5581
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0086 0.0776
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0045 0.0096 0.0817
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0042 0.0089 0.0087
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3166 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0049 0.0109 0.121
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.1161
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0042 0.0089 0.0087
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0036 0.1197
Loa Loa (eye worm) hypothetical protein 0.0031 0.0053 0.045
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0086 0.0913
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.1161
Entamoeba histolytica protein kinase rad3, putative 0.0124 0.0349 0.5228
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.1164
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0221 0.0654 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0053 0.0472
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0089 0.0703
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Echinococcus multilocularis serine protein kinase ATM 0.0124 0.0349 0.0347
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0221 0.0654 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0089 0.0562
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0158 0.1441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0089 0.0562
Entamoeba histolytica hypothetical protein 0.0124 0.0349 0.5228
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0121 0.012
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0042 0.0089 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Toxoplasma gondii thioredoxin reductase 0.0055 0.0128 0.1775
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.0395 0.4881
Brugia malayi glutathione reductase 0.0055 0.0128 0.1038
Echinococcus granulosus lysosomal alpha glucosidase 0.0155 0.0445 0.0444
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0221 0.0654 0.1783
Mycobacterium ulcerans hypothetical protein 0.0041 0.0086 0.4055
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0086 0.0537
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0089 0.0806
Schistosoma mansoni peptidase Clp (S14 family) 0.0074 0.019 0.1739
Entamoeba histolytica hypothetical protein 0.0042 0.0089 0.1161
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0013
Onchocerca volvulus 0.0042 0.0089 0.0282
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0128 0.0126
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0089 0.1164
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0086 0.0913
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0384 0.1172 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0086 0.0913
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0042 0.0089 0.0562
Leishmania major hypothetical protein, conserved 0.0041 0.0086 0.0198
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0015 0.0001
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0221 0.0654 0.1783
Toxoplasma gondii FATC domain-containing protein 0.0124 0.0349 0.523
Leishmania major trypanothione reductase 0.0055 0.0128 0.0316
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0128 0.1457
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0128 0.0329
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.0126
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.0395 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0089 0.1164
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0042 0.0089 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0086 0.0776
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0042 0.0089 0.0087
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0121 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0221 0.0654 0.6023
Leishmania major alpha glucosidase II subunit, putative 0.0034 0.0063 0.0136
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.0395 0.4881
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0123 0.0121
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0015 0.0066
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0121
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0063 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0158 0.1346
Echinococcus granulosus roundabout 2 0.0018 0.0011 0.0009
Brugia malayi Glycosyl hydrolases family 31 protein 0.0034 0.0063 0.0483
Loa Loa (eye worm) hypothetical protein 0.0041 0.0086 0.0731
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0074 0.019 0.2743
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0074 0.019 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0042 0.0089 0.0087
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0055 0.0129 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0129 0.0127
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0089 0.1164
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0121 0.098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0221 0.0654 0.1852
Brugia malayi Pre-SET motif family protein 0.0384 0.1172 1
Trichomonas vaginalis esterase, putative 0.0041 0.0086 0.0537
Brugia malayi Importin beta-1 subunit 0.0033 0.006 0.0457
Giardia lamblia Hypothetical protein 0.0042 0.0089 0.1164
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0034 0.0063 0.054
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0049 0.0109 0.121
Loa Loa (eye worm) hypothetical protein 0.0042 0.0089 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0015 0.0002
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0089 0.0562
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0089 0.0087
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0124 0.0349 0.0347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0121 0.1104
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0089 0.0806
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0042 0.0089 0.0087
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.1161
Brugia malayi RNA binding protein 0.0064 0.0158 0.1294
Mycobacterium ulcerans beta-lactamase 0.0041 0.0086 0.4055
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0221 0.0654 0.1783
Plasmodium falciparum importin beta, putative 0.0033 0.006 0.2606
Loa Loa (eye worm) hypothetical protein 0.0139 0.0394 0.3362
Onchocerca volvulus 0.0041 0.0086 0.0256
Echinococcus granulosus intermediate filament protein 0.0031 0.0053 0.0051
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0015 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.0349 0.2523
Trypanosoma brucei glucosidase, putative 0.0034 0.0063 0.0762
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0086 0.0913
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0089 0.0562
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0013
Brugia malayi beta-lactamase family protein 0.0041 0.0086 0.0675
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0015 0.0011
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0042 0.0089 0.1164
Onchocerca volvulus 0.0042 0.0089 0.0282
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.4243
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0158 0.1441
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0089 0.0562
Loa Loa (eye worm) hypothetical protein 0.0082 0.0214 0.1829
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0124 0.0349 0.5228
Mycobacterium ulcerans lipase LipD 0.0041 0.0086 0.4055
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0086 0.0206
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.0395 0.4881
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0221 0.0654 0.0653
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0015 0.0001
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0124 0.0349 0.523
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0042 0.0089 0.0562
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0063 0.0368
Schistosoma mansoni fkbp-rapamycin associated protein 0.0124 0.0349 0.3206
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0089 0.0562
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.0534 0.4552
Trichomonas vaginalis importin beta-1, putative 0.0027 0.004 0.0194
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0042 0.0089 0.0562
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0042 0.0089 0.1161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0221 0.0654 0.1852
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0128 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0129 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0221 0.0654 0.4824
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0036 0.1197
Plasmodium falciparum glutathione reductase 0.0055 0.0128 0.6469
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0089 0.0562
Echinococcus multilocularis lysosomal alpha glucosidase 0.0155 0.0445 0.0444
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0221 0.0654 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0042 0.0089 0.0806
Entamoeba histolytica hypothetical protein 0.0042 0.0089 0.1161

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1028 nM Inhibition of VEGF-stimulated HUVEC cell proliferation after 72 hrs ChEMBL. 17696416
IC50 (functional) = 1028 nM Inhibition of VEGF-stimulated HUVEC cell proliferation after 72 hrs ChEMBL. 17696416
Ki (functional) = 40 nM Inhibition of KDR phosphorylation ChEMBL. 17696416
Ki (functional) = 40 nM Inhibition of KDR phosphorylation ChEMBL. 17696416

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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