Detailed information for compound 443596

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 634.612 | Formula: C32H42Cl2FN5O3
  • H donors: 1 H acceptors: 3 LogP: 5.16 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](c1cc(F)ccc1N1CCN(CC1)C(=O)[C@H](N1CCCC1=O)Cc1ccc(cc1Cl)Cl)NC(=O)CN(C)C)C
  • InChi: 1S/C32H42Cl2FN5O3/c1-21(2)16-27(36-30(41)20-37(3)4)25-19-24(35)9-10-28(25)38-12-14-39(15-13-38)32(43)29(40-11-5-6-31(40)42)17-22-7-8-23(33)18-26(22)34/h7-10,18-19,21,27,29H,5-6,11-17,20H2,1-4H3,(H,36,41)/t27-,29+/m0/s1
  • InChiKey: JZDBOFKXYADYQD-LMSSTIIKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens melanocortin 4 receptor Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus g protein coupled receptor 0.0013 0.0066 0.0066
Brugia malayi follicle stimulating hormone receptor 0.0141 0.1027 0.1027
Echinococcus granulosus neuropeptide receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.0066 0.0066
Leishmania major methionine aminopeptidase 2, putative 0.1334 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.0066 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0066 0.0066
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Trypanosoma cruzi nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0066 0.0066
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.0066 0.0066
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.0066 0.0066
Schistosoma mansoni nicalin (M28 family) 0.0005 0.0004 0.0004
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) DNA-binding protein 0.0166 0.1211 0.1211
Onchocerca volvulus Fxna peptidase homolog 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0066 0.0066
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.0066 0.0066
Schistosoma mansoni notch 0.0005 0.0002 0.0002
Echinococcus multilocularis serotonin receptor 0.0013 0.0066 0.0066
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0029 0.0181 0.0177
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0066 0.0066
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0166 0.1211 0.1211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0166 0.1211 0.1211
Toxoplasma gondii creatinase domain-containing protein 0.0166 0.1211 0.1211
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0013 0.0066 0.0066
Trypanosoma brucei unspecified product 0.0029 0.0181 0.0177
Trypanosoma cruzi nucleobase transporter, putative 0.0029 0.0181 0.0177
Giardia lamblia Methionine aminopeptidase 0.1334 1 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0166 0.1211 0.1211
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0066 0.0066
Giardia lamblia Xaa-Pro dipeptidase 0.0166 0.1211 0.1211
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Toxoplasma gondii peptidase D, putative 0.0166 0.1211 0.1211
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0166 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Schistosoma mansoni myosin xvIII 0.0013 0.0066 0.0066
Echinococcus granulosus equilibrative nucleoside transporter 3 0.0165 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Trypanosoma cruzi aminopeptidase P1, putative 0.0166 0.1211 0.1207
Giardia lamblia Hypothetical protein 0.0165 0.1207 0.1207
Echinococcus multilocularis GPCR, family 2 0.0009 0.0031 0.0031
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Giardia lamblia Xaa-Pro dipeptidase 0.0166 0.1211 0.1211
Onchocerca volvulus Peroxidasin homolog 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Onchocerca volvulus 0.0104 0.0746 0.0746
Trypanosoma cruzi nucleobase transporter, putative 0.0029 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni Fxna peptidase (M28 family) 0.0005 0.0004 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.0066 0.0066
Entamoeba histolytica methionine aminopeptidase, putative 0.1334 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.0066 0.0066
Loa Loa (eye worm) methionine aminopeptidase type I 0.0166 0.1211 0.1211
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0005 0.0004 0.0004
Trypanosoma brucei unspecified product 0.0029 0.0181 0.0177
Brugia malayi FXNA 0.0005 0.0004 0.0004
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0007 0.0018 0.0118
Onchocerca volvulus 0.0013 0.0066 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0166 0.1211 0.1207
Echinococcus multilocularis peroxidasin 0.0104 0.0746 0.0746
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0051 0.0349 0.0349
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0066 0.0066
Schistosoma mansoni neuropeptide receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.0066 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0746 0.0746
Onchocerca volvulus Chorion peroxidase homolog 0.0104 0.0746 0.0746
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni biogenic amine receptor 0.0013 0.0066 0.0066
Schistosoma mansoni biogenic amine receptor 0.0013 0.0066 0.0066
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis neuropeptide s receptor 0.0269 0.1988 0.1988
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.0066 0.0066
Onchocerca volvulus Peroxidase homolog 0.0104 0.0746 0.0746
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0005 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0009 0.0031 0.0031
Echinococcus granulosus allatostatin A receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni equilibrative nucleoside transporter 0.0029 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0066 0.0066
Trypanosoma brucei adenosine transporter 2, putative 0.0029 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0165 0.1207 0.1207
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0746 0.0746
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus neuropeptide receptor A26 0.0269 0.1988 0.1988
Treponema pallidum methionine aminopeptidase (map) 0.0166 0.1211 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Trypanosoma brucei adenosine transporter 2 0.0029 0.0181 0.0177
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0029 0.0181 0.0177
Trypanosoma brucei adenosine transporter 2 0.0029 0.0181 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.0066 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0013 0.0066 0.0066
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0166 0.1211 0.1207
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0073 0.0512 0.0512
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0066 0.0066
Brugia malayi GnHR receptor homolog 0.0013 0.0066 0.0066
Brugia malayi Peptidase family M28 containing protein 0.0005 0.0004 0.0004
Echinococcus granulosus xaa Pro dipeptidase 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0166 0.1211 1
Echinococcus granulosus g protein coupled receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis equilibrative nucleoside transporter protein 0.0165 0.1207 0.1207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Onchocerca volvulus Neurogenic locus notch homolog 0.0005 0.0002 0.0002
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0166 0.1211 0.1211
Brugia malayi Peroxidasin 0.0104 0.0746 0.0746
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0029 0.0181 0.0177
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0746 0.0746
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0166 0.1211 0.1211
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0005 0.0004 0.0004
Trypanosoma brucei nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0165 0.1207 0.1203
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0077 0.0077
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0066 0.0066
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0166 0.1211 0.1207
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.0181
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0165 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni protein kinase 0.0029 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni neuropeptide receptor 0.0013 0.0066 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0066 0.0066
Schistosoma mansoni amine GPCR 0.0013 0.0066 0.0066
Brugia malayi metallopeptidase family M24 containing protein 0.0166 0.1211 0.1211
Brugia malayi G-protein coupled receptor 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi RE15519p 0.0013 0.0066 0.0066
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0166 0.1211 0.1211
Loa Loa (eye worm) transcription factor SMAD2 0.0066 0.0464 0.0464
Echinococcus multilocularis xaa Pro dipeptidase 0.0166 0.1211 0.1211
Loa Loa (eye worm) blistered cuticle protein 3 0.0104 0.0746 0.0746
Onchocerca volvulus 0.0013 0.0066 0.0066
Brugia malayi neuropeptide F receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) leucyl aminopeptidase 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi ORL1-like opioid receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis Proliferation associated protein 2G4 0.0166 0.1211 0.1211
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Toxoplasma gondii methionine aminopeptidase 0.0166 0.1211 0.1211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0077 0.0077
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.008 0.0565 0.0565
Trypanosoma brucei adenosine transporter, putative 0.0029 0.0181 0.0177
Trypanosoma brucei adenosine transporter, putative 0.0029 0.0181 0.0177
Brugia malayi G-protein coupled receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni histamine h1 receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0077 0.0077
Schistosoma mansoni biogenic amine receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Trypanosoma brucei adenosine transporter 2, putative 0.0029 0.0181 0.0177
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0104 0.0746 0.0746
Brugia malayi larval opioid receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0029 0.0181 0.0181
Echinococcus granulosus peroxidasin 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0053 0.0363 0.0363
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0066
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0166 0.1211 0.1211
Toxoplasma gondii methionine aminopeptidase 0.0166 0.1211 0.1211
Onchocerca volvulus 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Treponema pallidum aminopeptidase P 0.0166 0.1211 0.5
Brugia malayi Methionine aminopeptidase protein type I 0.0166 0.1211 0.1211
Leishmania major nucleobase transporter 0.0029 0.0181 0.0177
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Mycobacterium leprae Probable cytoplasmic peptidase PepQ 0.0166 0.1211 0.5
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0166 0.1211 0.1207
Trypanosoma cruzi nucleoside transporter-like, putative 0.0029 0.0181 0.0177
Onchocerca volvulus 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0166 0.1211 0.1211
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.0066 0.0066
Schistosoma mansoni opsin-like receptor 0.0013 0.0066 0.0066
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0066 0.0066
Toxoplasma gondii nucleoside transporter protein 0.0029 0.0181 0.0181
Onchocerca volvulus Dipeptidase C homolog 0.0166 0.1211 0.1211
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0136 0.0991 0.0991
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.0066 0.0066
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0007 0.0018 0.0118
Echinococcus granulosus equilibrative nucleoside transporter 0.0165 0.1207 0.1207
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.0066 0.0066
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Echinococcus granulosus hypothetical protein 0.0013 0.0066 0.0066
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0077 0.0073
Onchocerca volvulus 0.0013 0.0066 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0029 0.0181 0.0177
Brugia malayi Dopamine receptor protein 2 0.0013 0.0066 0.0066
Entamoeba histolytica nucleoside transporter, putative 0.0165 0.1207 0.1045
Mycobacterium ulcerans dipeptidase 0.0166 0.1211 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0028 0.0173 0.0173
Echinococcus multilocularis xaa pro aminopeptidase 0.0166 0.1211 0.1211
Echinococcus multilocularis serotonin receptor 0.0013 0.0066 0.0066
Toxoplasma gondii nucleoside transporter protein 0.0029 0.0181 0.0181
Brugia malayi Dopamine receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0165 0.1207 0.1203
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.0066 0.0066
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.1334 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0028 0.0173 0.0173
Echinococcus multilocularis equilibrative nucleoside transporter 3 0.0165 0.1207 0.1207
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0029 0.0181 0.0177
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Trypanosoma cruzi nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Schistosoma mansoni hypothetical protein 0.0009 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi Cytochrome P450 family protein 0.0015 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0166 0.1211 0.5
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.0066 0.0066
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.0066 0.0066
Brugia malayi Nucleoside transporter family protein 0.0165 0.1207 0.1207
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.0066 0.0066
Plasmodium vivax methionine aminopeptidase 2, putative 0.1334 1 1
Brugia malayi AKH receptor 0.0013 0.0066 0.0066
Schistosoma mansoni amine GPCR 0.0013 0.0066 0.0066
Onchocerca volvulus Fxna peptidase homolog 0.0005 0.0004 0.0004
Schistosoma mansoni opsin-like receptor 0.0013 0.0066 0.0066
Brugia malayi Melatonin receptor type 1A 0.0013 0.0066 0.0066
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.0066 0.0066
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0013 0.0066 0.0066
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0029 0.0181 0.0177
Onchocerca volvulus Glutaminyl cyclase homolog 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Onchocerca volvulus 0.0013 0.0066 0.0066
Echinococcus granulosus neuropeptide receptor 0.0013 0.0066 0.0066
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0166 0.1211 0.1211
Echinococcus granulosus methionine aminopeptidase type I 0.0166 0.1211 0.1211
Trypanosoma brucei methionine aminopeptidase, putative 0.0166 0.1211 0.1207
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0029 0.0181 0.0177
Onchocerca volvulus 0.0005 0.0004 0.0004
Brugia malayi metallopeptidase family M24 containing protein 0.0166 0.1211 0.1211
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Echinococcus multilocularis FACT complex subunit SPT16 0.0166 0.1211 0.1211
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.0066 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.0066 0.0066
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0009 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.0066 0.0066
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0005 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0004 0.0004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0009 0.0031 0.0031
Trypanosoma cruzi nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0009 0.0031 0.0031
Leishmania major nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Echinococcus granulosus GPCR family 2 0.0009 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.0066 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.0066 0.0066
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.1334 1 1
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0166 0.1211 0.5
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi Cytochrome P450 family protein 0.0015 0.0077 0.0077
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis methionyl aminopeptidase 2 0.1334 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0066 0.0066
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0077 0.0603
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0166 0.1211 0.1207
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Mycobacterium tuberculosis Dipeptidase PepE 0.0166 0.1211 1
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0005 0.0004 0.0004
Onchocerca volvulus 0.0013 0.0066 0.0066
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.0066 0.0066
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.0066 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0019 0.0107 0.0107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.0066 0.0066
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0166 0.1211 0.1211
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.1334 1 1
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0009 0.0031 0.0031
Brugia malayi neuropeptide F receptor 0.0013 0.0066 0.0066
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0029 0.0181 0.0177
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.1334 1 1
Onchocerca volvulus Dual oxidase homolog 0.0104 0.0746 0.0746
Trypanosoma brucei purine nucleoside transporter 0.0029 0.0181 0.0177
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0066 0.0066
Echinococcus granulosus FACT complex subunit SPT16 0.0166 0.1211 0.1211
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.1334 1 1
Trypanosoma brucei methionine aminopeptidase 2, putative 0.1334 1 1
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0166 0.1211 0.1211
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.0066 0.0066
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0746 0.0746
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.0066 0.0066
Brugia malayi metallopeptidase family M24 containing protein 0.0166 0.1211 0.1211
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0029 0.0181 0.0177
Trypanosoma cruzi nucleobase transporter, putative 0.0029 0.0181 0.0177
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Echinococcus multilocularis fmrfamide receptor 0.0013 0.0066 0.0066
Schistosoma mansoni neuropeptide receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0165 0.1207 0.1203
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0166 0.1211 0.5
Leishmania major hypothetical protein, conserved 0.0166 0.1211 0.1207
Echinococcus granulosus orexin receptor type 2 0.0013 0.0066 0.0066
Echinococcus multilocularis somatostatin receptor 0.0013 0.0066 0.0066
Toxoplasma gondii nucleoside transporter protein 0.0029 0.0181 0.0181
Brugia malayi hypothetical protein 0.0104 0.0746 0.0746
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0009 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi Xaa-Pro aminopeptidase 0.0166 0.1211 0.5
Chlamydia trachomatis aminopeptidase P 0.0166 0.1211 0.5
Echinococcus multilocularis methionine aminopeptidase, type I 0.0166 0.1211 0.1211
Trypanosoma brucei nucleobase/nucleoside transporter 8.1 0.0029 0.0181 0.0177
Brugia malayi Calcitonin receptor-like protein seb-1 0.0028 0.0173 0.0173
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Schistosoma mansoni peroxidasin 0.0104 0.0746 0.0746
Onchocerca volvulus 0.0013 0.0066 0.0066
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0029 0.0181 0.0177
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0166 0.1211 0.1211
Echinococcus granulosus g protein coupled receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0078 0.0551 0.0551
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.0066 0.0066
Trypanosoma brucei adenosine transporter 2, putative 0.0029 0.0181 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Toxoplasma gondii hypothetical protein 0.0005 0.0004 0.0004
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.0066 0.0066
Trypanosoma brucei adenosine transporter 2, putative 0.0029 0.0181 0.0177
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.1334 1 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis allatostatin A receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis xaa Pro dipeptidase 0.0166 0.1211 0.1211
Brugia malayi putative neuropeptide receptor 0.0013 0.0066 0.0066
Brugia malayi Animal haem peroxidase family protein 0.0104 0.0746 0.0746
Entamoeba histolytica hypothetical protein, conserved 0.0166 0.1211 0.1049
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Plasmodium falciparum methionine aminopeptidase 2 0.1334 1 1
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0005 0.0004 0.0004
Schistosoma mansoni adenoreceptor 0.0013 0.0066 0.0066
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0005 0.0004 0.0004
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.0066 0.0066
Schistosoma mansoni peptidase 0.0166 0.1211 0.1211
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0166 0.1211 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0028 0.0173 0.0173
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Echinococcus multilocularis sex peptide receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0066 0.0066
Leishmania major nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.0066 0.0066
Brugia malayi hypothetical protein 0.0165 0.1207 0.1207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Onchocerca volvulus 0.0104 0.0746 0.0746
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0009 0.0031 0.0031
Brugia malayi G protein-coupled receptor 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Onchocerca volvulus Equilibrative nucleoside transporter, putative homolog 0.0165 0.1207 0.1207
Mycobacterium ulcerans dipeptidase PepE 0.0166 0.1211 1
Onchocerca volvulus Peroxidasin homolog 0.0104 0.0746 0.0746
Schistosoma mansoni amine GPCR 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni opsin-like receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.0066 0.0066
Echinococcus granulosus serotonin receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0009 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0013 0.0066 0.0066
Trypanosoma brucei purine nucleoside transporter 0.0029 0.0181 0.0177
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.0066 0.0066
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0077 0.0073
Echinococcus granulosus methionyl aminopeptidase 2 0.1334 1 1
Schistosoma mansoni amine GPCR 0.0013 0.0066 0.0066
Mycobacterium ulcerans methionine aminopeptidase 0.0166 0.1211 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Brugia malayi Latrophilin receptor protein 2 0.0009 0.0031 0.0031
Toxoplasma gondii peptidase, M28 family protein 0.0005 0.0004 0.0004
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.0066 0.0066
Toxoplasma gondii methionine aminopeptidase 2, putative 0.1334 1 1
Trichomonas vaginalis equilibrative nucleoside transporter, putative 0.0165 0.1207 0.1203
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Onchocerca volvulus Fxna peptidase homolog 0.0005 0.0004 0.0004
Onchocerca volvulus Peroxidase homolog 0.0104 0.0746 0.0746
Trypanosoma cruzi nucleoside transporter-like, putative 0.0029 0.0181 0.0177
Trypanosoma brucei adenosine transporter 2, putative 0.0029 0.0181 0.0177
Brugia malayi nicalin 0.0005 0.0004 0.0004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.0066 0.0066
Trypanosoma brucei Metallopeptidase family M24, putative 0.0166 0.1211 0.1207
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) animal heme peroxidase 0.0104 0.0746 0.0746
Mycobacterium ulcerans aminopeptidase 0.0166 0.1211 1
Leishmania major cytochrome p450-like protein 0.0015 0.0077 0.0073
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0166 0.1211 0.1207
Onchocerca volvulus 0.0013 0.0066 0.0066
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.0066 0.0066
Loa Loa (eye worm) initiation factor 2-associated protein 0.1334 1 1
Entamoeba histolytica aminopeptidase, putative 0.0166 0.1211 0.1049
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0166 0.1211 0.1211
Echinococcus multilocularis neuropeptide receptor A26 0.0269 0.1988 0.1988
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0166 0.1211 0.1211
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0166 0.1211 1
Echinococcus granulosus Proliferation associated protein 2G4 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi MH2 domain containing protein 0.0066 0.0464 0.0464
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.0066 0.0066
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0166 0.1211 0.1207
Onchocerca volvulus 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0107
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0166 0.1211 0.1207
Brugia malayi Blistered cuticle protein 3 0.0104 0.0746 0.0746
Brugia malayi Serotonin receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0165 0.1207 0.1207
Echinococcus granulosus xaa pro aminopeptidase 0.0166 0.1211 0.1211
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Toxoplasma gondii transcriptional elongation factor FACT140 0.0166 0.1211 0.1211
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0166 0.1211 0.1211
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0077 0.0073
Brugia malayi Serotonin receptor 0.0013 0.0066 0.0066
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.0066 0.0066
Trypanosoma brucei nucleobase/nucleoside transporter 8.1, putative 0.0029 0.0181 0.0177
Loa Loa (eye worm) hypothetical protein 0.0165 0.1207 0.1207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni peroxidasin 0.0104 0.0746 0.0746
Schistosoma mansoni hypothetical protein 0.0013 0.0066 0.0066
Trypanosoma brucei nucleoside transporter 1, putative 0.0029 0.0181 0.0177
Echinococcus granulosus xaa Pro dipeptidase 0.0166 0.1211 0.1211
Echinococcus granulosus somatostatin receptor 0.0013 0.0066 0.0066
Brugia malayi sulfakinin receptor protein 0.0013 0.0066 0.0066
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.1334 1 1
Brugia malayi leucyl aminopeptidase 0.0005 0.0004 0.0004
Leishmania major nucleobase transporter 0.0029 0.0181 0.0177
Echinococcus granulosus fmrfamide receptor 0.0013 0.0066 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0066 0.0066
Echinococcus multilocularis orexin receptor type 2 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0166 0.1211 0.1211
Chlamydia trachomatis methionine aminopeptidase 0.0166 0.1211 0.5
Echinococcus granulosus g-protein coupled receptor 0.0013 0.0066 0.0066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.0009 0.0031 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0141 0.1027 0.1027
Onchocerca volvulus 0.0013 0.0066 0.0066
Trypanosoma cruzi aminopeptidase P, putative 0.0166 0.1211 0.1207
Entamoeba histolytica peptidase, putative 0.0166 0.1211 0.1049
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.0066 0.0066
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.0066 0.0066
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0166 0.1211 0.1211
Loa Loa (eye worm) hypothetical protein 0.0104 0.0746 0.0746
Leishmania major transcription factor-like protein 0.0166 0.1211 0.1207
Echinococcus granulosus neuropeptide s receptor 0.0269 0.1988 0.1988
Onchocerca volvulus 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0166 0.1211 0.1207
Brugia malayi hypothetical protein 0.0013 0.0066 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0009 0.0031 0.0031
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0166 0.1211 0.1207
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Brugia malayi Dopamine receptor protein 1 0.0013 0.0066 0.0066
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.1334 1 1
Leishmania major inosine-guanosine transporter;with=GeneDB:LinJ36_V3.2040 0.0029 0.0181 0.0177
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.1334 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.0066 0.0066
Echinococcus granulosus sex peptide receptor 0.0013 0.0066 0.0066
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0166 0.1211 0.1211
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.0066 0.0066
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.0066 0.0066
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0066
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0166 0.1211 1
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0166 0.1211 0.1049

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) = 15000 nM Inhibition of microsomal CYP3A4 ChEMBL. 17822895
IC50 (ADMET) = 15000 nM Inhibition of microsomal CYP3A4 ChEMBL. 17822895
Ki (binding) = 23 nM Binding affinity at human MC4R ChEMBL. 17822895
Ki (binding) = 23 nM Binding affinity at human MC4R ChEMBL. 17822895

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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