TDR Targets

Basic information

Technical information

TDR Targets ID: 49082
Name: methyl N-[4-chloro-3-(5-chloro-1,3-benzoxazol -2-yl)phenyl]carbamate
MW: 337.158 | Formula: C15H10Cl2N2O3
H donors: 1 H acceptors: 2 LogP: 4.26 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)Nc1ccc(c(c1)c1nc2c(o1)ccc(c2)Cl)Cl
InChi: 1S/C15H10Cl2N2O3/c1-21-15(20)18-9-3-4-11(17)10(7-9)14-19-12-6-8(16)2-5-13(12)22-14/h2-7H,1H3,(H,18,20)
InChiKey: CPWCZAGTADVGTE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-chloro-3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]carbamic acid methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	1-acylglycerol-3-phosphate O-acyltransferase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri	Get druggable targets OG5_126904	All targets in OG5_126904
Leishmania infantum	1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Schistosoma japonicum	ko:K00655 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC2.3.1.51], putative	Get druggable targets OG5_126904	All targets in OG5_126904
Mycobacterium leprae	POSSIBLE TRANSMEMBRANE PHOSPHOLIPID BIOSYNTHESIS BIFUNCTIONAL ENZYME PLSC: PUTATIVE L-3-PHOSPHOSERINE PHOSPHATASE (O-PHOSPHOSERI	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus multilocularis	Phospholipid glycerol acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Brugia malayi	Acyltransferase family protein	Get druggable targets OG5_126904	All targets in OG5_126904
Treponema pallidum	lysophosphatidic acid acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Schistosoma mansoni	1-acyl-sn-glycerol-3-phosphate o-acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus granulosus	Phospholipid glycerol acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Candida albicans	potential acyltransferase similar to S. cerevisiae SLC1 (YDL052C) 1-acylglycerol-3-phosphate O-acyltransferase involved in sphin	Get druggable targets OG5_126904	All targets in OG5_126904
Leishmania mexicana	1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus granulosus	1 acyl sn glycerol 3 phosphate acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Plasmodium falciparum	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Loa Loa (eye worm)	acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Candida albicans	potential acyltransferase similar to S. cerevisiae SLC1 (YDL052C) 1-acylglycerol-3-phosphate O-acyltransferase involved in sphin	Get druggable targets OG5_126904	All targets in OG5_126904
Mycobacterium ulcerans	bifunctional transmembrane phospholipid biosynthesis enzyme PlsC	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus granulosus	1 acyl sn glycerol 3 phosphate acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus multilocularis	homeobox	Get druggable targets OG5_126904	All targets in OG5_126904
Trypanosoma brucei gambiense	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Wolbachia endosymbiont of Brugia malayi	1-acyl-sn-glycerol-3-phosphate acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Cryptosporidium parvum	glycerol-3-phosphate acyltransferase family, possible plant origin, possible signal peptide plus 2 transmembrane domains	Get druggable targets OG5_126904	All targets in OG5_126904
Toxoplasma gondii	acyltransferase domain-containing protein	Get druggable targets OG5_126904	All targets in OG5_126904
Trypanosoma brucei	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Plasmodium yoelii	1-acyl-sn-glycerol-3-phosphate acyltransferase (ec 2.3.1.51) (1-agp acyltransferase) (1-agpat) (lysophosphatidic acid acyltransf	Get druggable targets OG5_126904	All targets in OG5_126904
Leishmania braziliensis	1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Schistosoma mansoni	transcription factor	Get druggable targets OG5_126904	All targets in OG5_126904
Plasmodium knowlesi	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Babesia bovis	acyltransferase family protein	Get druggable targets OG5_126904	All targets in OG5_126904
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126904	All targets in OG5_126904
Toxoplasma gondii	acyltransferase domain-containing protein	Get druggable targets OG5_126904	All targets in OG5_126904
Trypanosoma cruzi	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Leishmania major	1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Plasmodium vivax	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Theileria parva	hypothetical protein	Get druggable targets OG5_126904	All targets in OG5_126904
Mycobacterium tuberculosis	1-acylglycerol-3-phosphate O-acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus granulosus	Msx-like	Get druggable targets OG5_126904	All targets in OG5_126904
Mycobacterium ulcerans	1-acylglycerol-3-phosphate O-acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus multilocularis	1 acyl sn glycerol 3 phosphate acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Neospora caninum	hypothetical protein	Get druggable targets OG5_126904	All targets in OG5_126904
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126904	All targets in OG5_126904
Neospora caninum	Lysophosphatidic acid acyltransferase, related	Get druggable targets OG5_126904	All targets in OG5_126904
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126904	All targets in OG5_126904
Trypanosoma congolense	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Plasmodium berghei	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Leishmania donovani	1-acyl-sn-glycerol-3-phosphateacyltransferase-l ik eprotein, putative	Get druggable targets OG5_126904	All targets in OG5_126904
Chlamydia trachomatis	glycerol-3-phosphate acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904
Echinococcus multilocularis	1 acyl sn glycerol 3 phosphate acyltransferase	Get druggable targets OG5_126904	All targets in OG5_126904

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Bromodomain containing protein	0.0041	0.0514	0.1245
Echinococcus granulosus	glycogen phosphorylase	0.012	0.1817	0.1808
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0113	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0678	0.1675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0468	0.1094
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0135	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0632	0.1539
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0305	0.0713
Schistosoma mansoni	thymidylate kinase	0.0078	0.1114	0.1226
Trichomonas vaginalis	cytidine deaminase, putative	0.0055	0.0735	0.1718
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0564	0.137
Schistosoma mansoni	ap endonuclease	0.0022	0.0197	0.0207
Plasmodium vivax	thymidylate kinase, putative	0.0078	0.1114	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.026	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0255	0.4047	1
Brugia malayi	Acyltransferase family protein	0.0018	0.0128	0.0288
Schistosoma mansoni	cpg binding protein	0.0033	0.0369	0.0398
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0011	0.0028
Trypanosoma cruzi	thymidine kinase, putative	0.0269	0.428	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0051	0.0678	0.0667
Toxoplasma gondii	thymidylate kinase	0.0078	0.1114	1
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0052	0.069	0.0584
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0197	0.0461
Trypanosoma cruzi	ribonuclease H1, putative	0.0021	0.0184	0.0202
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0048	0.0632	0.1274
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0113	0.0279
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0048	0.0632	0.1066
Brugia malayi	PHD-finger family protein	0.0029	0.0302	0.0721
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0036	0.0427	0.3832
Onchocerca volvulus		0.0055	0.0735	0.1786
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Echinococcus granulosus	glycogen phosphorylase	0.012	0.1817	0.1808
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Treponema pallidum	ribonuclease H (rnhA)	0.0021	0.0184	0.0575
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0197	0.0461
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0078	0.1114	0.3834
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0564	0.0554
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0468	0.1094
Onchocerca volvulus	Ribonuclease H1 homolog	0.0021	0.0184	0.0427
Brugia malayi	cytidine deaminase, identical	0.0055	0.0735	0.1794
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0048	0.0632	0.1274
Onchocerca volvulus		0.0033	0.0374	0.0894
Echinococcus granulosus	cpg binding protein	0.0033	0.0369	0.0358
Giardia lamblia	Glycogen phosphorylase	0.012	0.1817	0.3986
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.0691	0.1684
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0174	0.2701	0.2607
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0066	0.0923	0.0912
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0564	0.0615
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0113	0.0251
Loa Loa (eye worm)	thymidylate kinase	0.0078	0.1114	0.2754
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0214	0.0274
Echinococcus granulosus	1 acyl sn glycerol 3 phosphate acyltransferase	0.0018	0.0128	0.0116
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0199	0.0492
Trypanosoma brucei	ISWI complex protein	0.0017	0.0104	0.001
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0197	0.0233
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0839	0.0721
Giardia lamblia	GTOR	0.0048	0.0632	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0619	0.1529
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0197	0.0461
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.0135	0.0124
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0021	0.0184	0.0575
Schistosoma mansoni	bromodomain containing protein	0.007	0.0986	0.1084
Schistosoma mansoni	1-acyl-sn-glycerol-3-phosphate o-acyltransferase	0.0018	0.0128	0.0129
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0473	0.0462
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0369	0.0861
Schistosoma mansoni	hypothetical protein	0.0056	0.0753	0.0825
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0048	0.0632	0.1274
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0051	0.0678	0.0667
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0839	0.0829
Schistosoma mansoni	zinc finger protein	0.0017	0.0104	0.0103
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0839	0.0721
Echinococcus granulosus	Phospholipid glycerol acyltransferase	0.0018	0.0128	0.0116
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0678	0.0741
Echinococcus granulosus	ribonuclease H1	0.0021	0.0184	0.0173
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0113	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Chlamydia trachomatis	glycogen phosphorylase	0.012	0.1817	1
Leishmania major	1-acyl-sn-glycerol-3-phosphateacyltransferase-like protein, putative	0.0018	0.0128	0.0066
Schistosoma mansoni	hypothetical protein	0.008	0.1155	0.1272
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0197	0.0487
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0263	0.0615
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0078	0.1114	1
Echinococcus multilocularis	glycogen phosphorylase	0.012	0.1817	0.1808
Trypanosoma cruzi	ribonuclease H1, putative	0.0021	0.0184	0.0202
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0197	0.0186
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0174	0.2701	0.2618
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0113	0.0031
Trichomonas vaginalis	thymidine kinase, putative	0.0269	0.428	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0113	0.0102
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0048	0.0632	0.1274
Echinococcus granulosus	thymidylate kinase	0.0078	0.1114	0.1104
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0264	0.0616
Toxoplasma gondii	ribonuclease HI protein	0.0021	0.0184	0.1654
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0011	0.0028
Echinococcus granulosus	geminin	0.0555	0.9004	0.9003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0468	0.1094
Echinococcus multilocularis	thymidine phosphorylase	0.0615	1	1
Trypanosoma brucei	cytidine deaminase	0.0055	0.0735	0.152
Brugia malayi	Bromodomain containing protein	0.0083	0.1195	0.2934
Echinococcus multilocularis	zinc finger protein	0.0023	0.0207	0.0196
Entamoeba histolytica	Thymidylate kinase, putative	0.0078	0.1114	0.2246
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0264	0.0616
Echinococcus granulosus	Glycosyl transferase family 35	0.012	0.1817	0.1808
Loa Loa (eye worm)	glycogen phosphorylase	0.012	0.1817	0.449
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0473	0.0462
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0048	0.0632	0.1274
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0564	0.0554
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0039	0.0469	0.0883
Leishmania major	hypothetical protein, conserved	0.0017	0.0104	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0374	0.0403
Brugia malayi	hypothetical protein	0.0039	0.0473	0.1143
Trichomonas vaginalis	cytidine deaminase, putative	0.0055	0.0735	0.1718
Echinococcus multilocularis	Phospholipid glycerol acyltransferase	0.0018	0.0128	0.0116
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0113	0.0031
Entamoeba histolytica	hypothetical protein	0.0039	0.0473	0.0674
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0632	0.1477
Schistosoma mansoni	hypothetical protein	0.0039	0.0473	0.0513
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.031	0.0724
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0374	0.3354
Trypanosoma cruzi	target of rapamycin kinase 3	0.0039	0.0469	0.0883
Brugia malayi	F/Y-rich N-terminus family protein	0.0012	0.003	0.0047
Echinococcus multilocularis	glycogen phosphorylase	0.012	0.1817	0.1808
Schistosoma mansoni	phosphoglucomutase	0.0021	0.0184	0.0192
Mycobacterium tuberculosis	Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase)	0.0055	0.0735	0.063
Schistosoma mansoni	phosphoglucomutase	0.0021	0.0184	0.0192
Echinococcus multilocularis	ribonuclease H1	0.0021	0.0184	0.0173
Echinococcus multilocularis	Glycosyl transferase, family 35	0.012	0.1817	0.1808
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.026	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0515	0.1273
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0197	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0128	0.0315
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0104	0.001
Toxoplasma gondii	exonuclease III APE	0.0022	0.0197	0.177
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Trypanosoma cruzi	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0018	0.0128	0.0066
Loa Loa (eye worm)	bromodomain containing protein	0.0019	0.0146	0.0361
Echinococcus granulosus	Na+ dependent nucleoside transporter	0.035	0.562	0.5615
Entamoeba histolytica	cytidine deaminase, putative	0.0055	0.0735	0.1318
Echinococcus multilocularis	homeobox	0.0017	0.0115	0.0104
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0052	0.069	0.057
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0011	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0557	0.1377
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0564	0.0554
Schistosoma mansoni	glycogen phosphorylase	0.0052	0.069	0.0754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0632	0.1477
Trypanosoma cruzi	thymidylate kinase, putative	0.0078	0.1114	0.2427
Schistosoma mansoni	phosphoglucomutase	0.0021	0.0184	0.0192
Mycobacterium tuberculosis	Possible transmembrane phospholipid biosynthesis bifunctional enzyme PlsC: putative L-3-phosphoserine phosphatase (O-phosphoseri	0.0017	0.0115	0.0003
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0078	0.1114	0.1013
Brugia malayi	RNase H family protein	0.0021	0.0184	0.0429
Onchocerca volvulus	Putative thymidylate kinase	0.0078	0.1114	0.2721
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0615	1	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0113	0.0102
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0174	0.2701	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0197	0.0706
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0128	0.0315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Toxoplasma gondii	acyltransferase domain-containing protein	0.0018	0.0128	0.1144
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0308	0.0735
Schistosoma mansoni	glycogen phosphorylase	0.012	0.1817	0.2008
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0197	0.0233
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0016	0.01	0.0089
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0564	0.0615
Echinococcus granulosus	cytidine deaminase	0.0055	0.0735	0.0725
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0263	0.0615
Trypanosoma brucei	ingi protein (ORF1)	0.0023	0.0214	0.0274
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0011	0.0028
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.0113	0.1012
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0197	0.0706
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0351	0.0821
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0011	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1092	0.2698
Brugia malayi	hypothetical protein	0.0255	0.4047	1
Echinococcus multilocularis	1 acyl sn glycerol 3 phosphate acyltransferase	0.0018	0.0128	0.0116
Schistosoma mansoni	transcription factor	0.0017	0.0115	0.0116
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0011	0.0028
Mycobacterium ulcerans	thymidylate kinase	0.0078	0.1114	0.0999
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0023	0.0214	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0468	0.1094
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0264	0.0616
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0039	0.0469	0.0883
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0041	0.0515	0.1203
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0473	0.0513
Plasmodium vivax	SET domain protein, putative	0.0033	0.0374	0.2605
Schistosoma mansoni	thymidylate kinase	0.0078	0.1114	0.1226
Brugia malayi	carbohydrate phosphorylase	0.012	0.1817	0.4475
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0023	0.021	0.0264
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.01	0.0233
Schistosoma mansoni	hypothetical protein	0.0555	0.9004	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0264	0.0616
Plasmodium vivax	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0018	0.0128	0.0147
Trypanosoma brucei	RNA helicase, putative	0.008	0.1155	0.2525
Trichomonas vaginalis	thymidine kinase, putative	0.0269	0.428	1
Echinococcus granulosus	solute carrier family 28	0.035	0.562	0.5615
Plasmodium falciparum	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0018	0.0128	0.0147
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0048	0.0632	0.1274
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0839	0.1768
Trypanosoma brucei	thymidylate kinase, putative	0.0078	0.1114	0.2427
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0197	0.0233
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0039	0.0472	0.0461
Onchocerca volvulus		0.0052	0.0691	0.1677
Entamoeba histolytica	thymidine kinase, putative	0.0269	0.428	1
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.002	0.0164	0.0153
Trichomonas vaginalis	thymidylate kinase, putative	0.0078	0.1114	0.2603
Schistosoma mansoni	glycogen phosphorylase	0.012	0.1817	0.2008
Entamoeba histolytica	glycogen phosphorylase, putative	0.0052	0.069	0.1206
Entamoeba histolytica	glycogenphosphorylase, putative	0.0052	0.069	0.1206
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0016	0.01	0.0219
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0263	0.0615
Echinococcus multilocularis	cytidine deaminase	0.0055	0.0735	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0115	0.0285
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0011	0.0028
Trypanosoma brucei	1-acyl-sn-glycerol-3-phosphate acyltransferase, putative	0.0018	0.0128	0.0066
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.031	0.0724
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0839	0.0829
Trypanosoma cruzi	ISWI complex protein	0.0017	0.0104	0.001
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0344	0.0333
Echinococcus granulosus	concentrative Na nucleoside cotransporter	0.035	0.562	0.5615
Onchocerca volvulus		0.0055	0.0735	0.1786
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Onchocerca volvulus		0.0029	0.0308	0.0732
Entamoeba histolytica	hypothetical protein	0.0039	0.0473	0.0674
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0048	0.0632	0.0622
Toxoplasma gondii	cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein	0.0055	0.0735	0.6598
Trypanosoma cruzi	cytidine deaminase-like protein	0.0055	0.0735	0.152
Loa Loa (eye worm)	acyltransferase	0.0018	0.0128	0.0315
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0839	0.753
Entamoeba histolytica	glycogen phosphorylase, putative	0.0052	0.069	0.1206
Giardia lamblia	Cytidine deaminase	0.0055	0.0735	0.1345
Echinococcus granulosus	Msx-like	0.0017	0.0115	0.0104
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.003	0.0335	0.0562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0305	0.0713
Trypanosoma brucei	thymidine kinase	0.0269	0.428	1
Brugia malayi	follicle stimulating hormone receptor	0.0252	0.4002	0.989
Echinococcus multilocularis	1 acyl sn glycerol 3 phosphate acyltransferase	0.0018	0.0128	0.0116
Schistosoma mansoni	hypothetical protein	0.0017	0.0104	0.0103
Leishmania major	ribonuclease H1, putative	0.0021	0.0184	0.0202
Trichomonas vaginalis	set domain proteins, putative	0.0256	0.4064	0.9495
Leishmania major	thymidylate kinase-like protein	0.0078	0.1114	0.2427
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0839	0.0721
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0197	0.0071
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0048	0.0632	0.1066
Schistosoma mansoni	cpg binding protein	0.0029	0.0308	0.033
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.01	0.0233
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0197	0.0843
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0113	0.0031
Trypanosoma cruzi	thymidine kinase, putative	0.0269	0.428	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0048	0.0632	0.069
Loa Loa (eye worm)	phosphatidylinositol 3	0.0016	0.01	0.0247
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.031	0.0724
Trichomonas vaginalis	thymidylate kinase, putative	0.0078	0.1114	0.2603
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0839	0.0735
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0051	0.0678	0.0741
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0113	0.0251
Leishmania major	thymidine kinase, putative	0.0269	0.428	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0374	0.0363
Leishmania major	cytidine deaminase-like protein	0.0055	0.0735	0.152
Entamoeba histolytica	hypothetical protein	0.0039	0.0473	0.0674
Mycobacterium leprae	PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE)	0.0055	0.0735	0.2361
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0197	0.0233
Schistosoma mansoni	ap endonuclease	0.0022	0.0197	0.0207
Echinococcus multilocularis	solute carrier family 28	0.035	0.562	0.5615
Brugia malayi	thymidylate kinase	0.0078	0.1114	0.2733
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0113	0.0113
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0632	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Mycobacterium ulcerans	thymidine phosphorylase	0.0615	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0839	0.092
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0839	0.092
Trypanosoma brucei	thymidylate kinase, putative	0.0078	0.1114	0.2427
Giardia lamblia	CDC8	0.0078	0.1114	0.227
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0113	0.0102
Brugia malayi	RNase H family protein	0.0021	0.0184	0.0429
Trypanosoma cruzi	cytidine deaminase-like protein, putative	0.0055	0.0735	0.152
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0048	0.0632	0.0622
Entamoeba histolytica	hypothetical protein	0.0039	0.0473	0.0674
Mycobacterium tuberculosis	1-acylglycerol-3-phosphate O-acyltransferase	0.0018	0.0128	0.0015
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.0135	0.0124
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.026	0.0249
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0197	0.0031
Schistosoma mansoni	hypothetical protein	0.0555	0.9004	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0564	0.0554
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0308	0.0761
Brugia malayi	Pre-SET motif family protein	0.0225	0.3552	0.8773
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0011	0.0028
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0039	0.0472	0.0461
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0066	0.0923	0.0912
Schistosoma mansoni	zinc finger protein	0.0023	0.0207	0.0218
Onchocerca volvulus		0.0256	0.4064	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0225	0.3552	0.8777
Echinococcus multilocularis	thymidylate kinase	0.0078	0.1114	0.1104
Giardia lamblia	Thymidine kinase	0.0269	0.428	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0113	0.0102
Plasmodium falciparum	thymidylate kinase	0.0078	0.1114	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0113	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0113	0.0102
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0197	0.0843
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.01	0.0233
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.01	0.0233
Onchocerca volvulus	Glycogen phosphorylase homolog	0.012	0.1817	0.4455
Echinococcus granulosus	1 acyl sn glycerol 3 phosphate acyltransferase	0.0018	0.0128	0.0116
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0113	0.0031
Trypanosoma brucei	unspecified product	0.0023	0.0214	0.0274
Echinococcus multilocularis	concentrative Na+ nucleoside cotransporter	0.035	0.562	0.5615
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0252	0.4002	0.9891
Trichomonas vaginalis	thymidine kinase, putative	0.0269	0.428	1
Mycobacterium ulcerans	cytidine deaminase	0.0055	0.0735	0.0616
Leishmania major	hypothetical protein, conserved	0.003	0.0335	0.0562
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0468	0.1094
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0016	0.01	0.0089
Chlamydia trachomatis	thymidylate kinase	0.0078	0.1114	0.584
Trichomonas vaginalis	glycogen phosphorylase, putative	0.012	0.1817	0.4245
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0011	0.0028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0564	0.0615
Toxoplasma gondii	acyltransferase domain-containing protein	0.0018	0.0128	0.1144
Echinococcus granulosus	zinc finger protein	0.0023	0.0207	0.0196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0427	0.0998
Trypanosoma cruzi	thymidylate kinase, putative	0.0078	0.1114	0.2427
Echinococcus multilocularis	survival motor neuron protein 1	0.0255	0.4047	0.404
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0796	0.7145
Brugia malayi	RNase H family protein	0.0021	0.0184	0.0429
Entamoeba histolytica	glycogen phosphorylase, putative	0.012	0.1817	0.3967
Echinococcus multilocularis	sodium:nucleoside cotransporter 2	0.0228	0.3606	0.3599
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.0135	0.0138
Brugia malayi	Pre-SET motif family protein	0.0033	0.0374	0.0898
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0862	0.0946
Schistosoma mansoni	hypothetical protein	0.0022	0.0199	0.0209
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0197	0.0085
Trypanosoma brucei	ribonuclease H1	0.0021	0.0184	0.0202
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0016	0.01	0.0098
Echinococcus granulosus	survival motor neuron protein 1	0.0255	0.4047	0.404
Schistosoma mansoni	survival motor neuron protein	0.0052	0.0691	0.0756
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0013	0.0046	0.0108
Echinococcus multilocularis	cpg binding protein	0.0033	0.0369	0.0358
Entamoeba histolytica	glycogen phosphorylase, putative	0.012	0.1817	0.3967
Schistosoma mansoni	hypothetical protein	0.0052	0.0691	0.0756
Treponema pallidum	thymidylate kinase (tmk)	0.0078	0.1114	1
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.003	0.0335	0.0562
Trichomonas vaginalis	glycogen phosphorylase, putative	0.012	0.1817	0.4245
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0016	0.01	0.0233
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0564	0.1395
Schistosoma mansoni	hypothetical protein	0.0078	0.1114	0.1226
Echinococcus multilocularis	geminin	0.0555	0.9004	0.9003
Schistosoma mansoni	cpg binding protein	0.0033	0.0369	0.0398
Trypanosoma brucei	ingi protein (ORF1)	0.0023	0.0214	0.0274
Trichomonas vaginalis	ribonuclease H1, putative	0.0021	0.0184	0.0431
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0374	0.0403
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0632	0.1563

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibitory activity against human lysophosphatidic acid acyltransferase-alpha (LPAAT-alpha) expressed in Sf9 insect cell membranes at <20 uM; Not active	ChEMBL.	15006381
Activity (binding)	0	Inhibitory activity against human lysophosphatidic acid acyltransferase-alpha (LPAAT-alpha) expressed in Sf9 insect cell membranes at <20 uM; Not active	ChEMBL.	15006381
IC50 (binding)	= 0.3 uM	Inhibitory concentration against human lysophosphatidic acid acyltransferase-beta (LPAAT-beta) expressed in Sf9 insect cell membranes	ChEMBL.	15006381
IC50 (binding)	= 0.3 uM	Inhibitory concentration against human lysophosphatidic acid acyltransferase-beta (LPAAT-beta) expressed in Sf9 insect cell membranes	ChEMBL.	15006381

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL35582
PubChem: 9967612

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 49082