Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0031 | 0.0044 | 0.0146 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0055 | 0.0117 | 0.1164 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.011 | 0.1371 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0023 | 0.0019 | 0.0148 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.3327 | 1 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0272 | 0.0771 | 0.2859 |
Leishmania major | delta-6 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0069 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0023 | 0.0019 | 0.0148 |
Mycobacterium ulcerans | hypothetical protein | 0.0272 | 0.0771 | 0.0771 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0063 | 0.014 | 0.1405 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0124 | 0.0406 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0019 | 0.0062 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0272 | 0.0771 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.011 | 0.1093 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0272 | 0.0771 | 0.0771 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.011 | 0.0392 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.011 | 0.0359 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Echinococcus granulosus | lamin | 0.0031 | 0.0044 | 0.0512 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | FAT-3 protein | 0.0272 | 0.0771 | 0.252 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0186 |
Schistosoma mansoni | lamin | 0.0031 | 0.0044 | 0.0408 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Onchocerca volvulus | 0.0055 | 0.0117 | 0.0253 | |
Schistosoma mansoni | nuclear hormone receptor | 0.0023 | 0.0019 | 0.0148 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0023 | 0.0019 | 0.0053 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0018 | 0.0005 | 0.0015 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.103 | 0.306 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0272 | 0.0771 | 0.2859 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0018 | 0.0005 | 0.0015 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0272 | 0.0771 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0019 | 0.0053 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0023 | 0.0019 | 0.0186 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0023 | 0.0019 | 0.0053 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0186 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0272 | 0.0771 | 0.252 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | FTZ F1 alpha | 0.0023 | 0.0019 | 0.0186 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0019 | 0.0148 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0023 | 0.0019 | 0.0186 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0272 | 0.0771 | 0.1987 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0019 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0044 | 0.0146 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0044 | 0.0146 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0023 | 0.0019 | 0.0186 |
Brugia malayi | Fatty acid desaturase family protein | 0.0272 | 0.0771 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0042 | 0.0138 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0055 | 0.0117 | 0.0253 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0023 | 0.0019 | 0.0062 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.011 | 0.1371 |
Brugia malayi | mbt repeat family protein | 0.0055 | 0.0117 | 0.0381 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0063 | 0.014 | 0.1762 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0019 | 0.0186 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0023 | 0.0019 | 0.0148 |
Brugia malayi | acyl-CoA desaturase | 0.103 | 0.306 | 1 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0906 | 0.2686 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Fatty acid desaturase family protein | 0.0272 | 0.0771 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0272 | 0.0771 | 0.252 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0023 | 0.0019 | 0.0053 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0055 | 0.0117 | 0.146 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0063 | 0.014 | 0.0504 |
Schistosoma mansoni | thyroid hormone receptor | 0.0023 | 0.0019 | 0.0148 |
Brugia malayi | steroid hormone receptor | 0.0023 | 0.0019 | 0.0062 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.3327 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0069 | 0.0668 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0044 | 0.0512 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.011 | 0.0359 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0055 | 0.0117 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0117 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0044 | 0.0143 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.011 | 0.1093 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0023 | 0.0019 | 0.0148 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0069 | 0.0225 |
Schistosoma mansoni | lamin | 0.0031 | 0.0044 | 0.0408 |
Leishmania major | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0272 | 0.0771 | 0.252 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.3327 | 1 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0272 | 0.0771 | 1 |
Leishmania major | delta-5 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Leishmania major | stearic acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.103 | 0.306 | 0.7883 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0044 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0218 | 0.0608 | 0.7875 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0053 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.103 | 0.306 | 0.7883 |
Brugia malayi | nuclear hormone receptor | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0055 | 0.0117 | 0.1164 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0272 | 0.0771 | 0.0771 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Leishmania major | fatty-acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0019 | 0.0062 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.3327 | 1 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0272 | 0.0771 | 0.0771 |
Brugia malayi | mbt repeat family protein | 0.0055 | 0.0117 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.014 | 0.0457 |
Onchocerca volvulus | 0.0272 | 0.0771 | 0.1948 | |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0055 | 0.0117 | 0.0417 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0063 | 0.014 | 0.0457 |
Leishmania major | delta-4 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0124 | 0.0406 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0044 | 0.0408 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0023 | 0.0019 | 0.0148 |
Mycobacterium ulcerans | hypothetical protein | 0.0272 | 0.0771 | 0.0771 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0272 | 0.0771 | 0.0771 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0272 | 0.0771 | 0.2859 |
Brugia malayi | Cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Brugia malayi | ecdysteroid receptor | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Onchocerca volvulus | 0.1302 | 0.3882 | 1 | |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0063 | 0.014 | 0.1762 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0023 | 0.0019 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | fatty acid desaturase | 0.0272 | 0.0771 | 0.7974 |
Schistosoma mansoni | coup transcription factor | 0.0023 | 0.0019 | 0.0148 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0055 | 0.0117 | 0.0381 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0023 | 0.0019 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0005 | 0.0015 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0272 | 0.0771 | 0.1987 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0023 | 0.0019 | 0.0148 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0023 | 0.0019 | 0.0062 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0023 | 0.0019 | 0.0053 |
Onchocerca volvulus | 0.0031 | 0.0044 | 0.0065 | |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0017 | 0.0000013781 | 0.0000045041 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.011 | 0.0392 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0044 | 0.0143 |
Loa Loa (eye worm) | MBCTL1 | 0.0063 | 0.014 | 0.0457 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0018 | 0.0005 | 0.0015 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0017 | 0.0000013781 | 0.0000045041 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.3327 | 1 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.3327 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.3327 | 1 | 1 |
Onchocerca volvulus | 0.1302 | 0.3882 | 1 | |
Loa Loa (eye worm) | steroid hormone receptor | 0.0023 | 0.0019 | 0.0062 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0124 | 0.0406 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0023 | 0.0019 | 0.0148 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0055 | 0.0117 | 0.1164 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1302 | 0.3882 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0023 | 0.0019 | 0.0148 |
Leishmania major | delta-12 fatty acid desaturase | 0.0272 | 0.0771 | 0.1987 |
Brugia malayi | nuclear receptor NHR-88 | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.011 | 0.1093 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0063 | 0.014 | 0.0504 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0124 | 0.0406 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0023 | 0.0019 | 0.0062 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0023 | 0.0019 | 0.0062 |
Leishmania major | fatty acid desaturase, putative | 0.0272 | 0.0771 | 0.1987 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0044 | 0.0143 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0044 | 0.0143 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0044 | 0.0512 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0272 | 0.0771 | 0.0771 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0432 | 0.1255 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0272 | 0.0771 | 0.252 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0023 | 0.0019 | 0.0148 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0023 | 0.0019 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0337 | 0.0966 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0023 | 0.0019 | 0.0186 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0218 | 0.0608 | 0.2252 |
Onchocerca volvulus | 0.0031 | 0.0044 | 0.0065 | |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0023 | 0.0019 | 0.0053 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0019 | 0.0062 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0055 | 0.0117 | 0.146 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.004 ug ml-1 | Antifungal activity against Aspergillus fumigatus FP1305 | ChEMBL. | 18207736 |
LC50 (ADMET) | > 10 mg/ml | Effect on hemolysis in red blood cells (unknown origin) | ChEMBL. | 18207736 |
MIC (functional) | = 0.39 ug ml-1 | Antifungal activity against Candida albicans FP633 | ChEMBL. | 18207736 |
MIC (functional) | = 0.39 ug ml-1 | Antifungal activity against Candida albicans FP633 | ChEMBL. | 18207736 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.