Detailed information for compound 510151

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 737.865 | Formula: C36H47N7O8S
  • H donors: 3 H acceptors: 8 LogP: 3.47 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@H](C(C)(C)C)NC(=O)OC1CCCC1)n1nnc(c1)c1ccc2c(c1)CCO2)C(=O)NS(=O)(=O)C1CC1
  • InChi: 1S/C36H47N7O8S/c1-5-23-18-36(23,33(46)40-52(48,49)26-11-12-26)38-31(44)28-17-24(43-20-27(39-41-43)21-10-13-29-22(16-21)14-15-50-29)19-42(28)32(45)30(35(2,3)4)37-34(47)51-25-8-6-7-9-25/h5,10,13,16,20,23-26,28,30H,1,6-9,11-12,14-15,17-19H2,2-4H3,(H,37,47)(H,38,44)(H,40,46)/t23-,24-,28+,30-,36-/m1/s1
  • InChiKey: XGUXRDFEGNPUCY-UYXKJWDPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0079 0.0083
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0077 0.0073
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0693 0.069
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0019 0.0065 0.0094
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0077 1
Echinococcus multilocularis neuropeptide receptor 0.0085 0.048 0.0698
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.006 0.0088
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0994 0.6159 0.9304
Echinococcus multilocularis G-protein coupled receptor, putative 0.0085 0.048 0.0698
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0115
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0488 0.2997 0.4363
Brugia malayi Pre-SET motif family protein 0.0433 0.2654 0.3863
Schistosoma mansoni opsin-like receptor 0.0085 0.048 0.0503
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0115
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1108 0.6869 1
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0029 0.0005
Loa Loa (eye worm) hypothetical protein 0.0348 0.2123 0.3091
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0021 0.0022
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0077 0.1057
Schistosoma mansoni biogenic amine (5HT) receptor 0.0481 0.2952 0.3094
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus multilocularis neuropeptide receptor A26 0.0085 0.048 0.0698
Echinococcus granulosus biogenic amine 5HT receptor 0.0454 0.2784 0.4053
Brugia malayi Dopamine receptor 0.0085 0.048 0.0698
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0085 0.048 0.0698
Trypanosoma brucei glucosidase, putative 0.0035 0.0166 0.0205
Brugia malayi Serotonin receptor 0.0085 0.048 0.0698
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0149 0.0145
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0077 0.0112
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0149 1
Onchocerca volvulus 0.0085 0.048 0.1567
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0046 0.0125
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.006 0.0174
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.151 0.1506
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus multilocularis g protein coupled receptor 0.0085 0.048 0.0698
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0149 0.0145
Schistosoma mansoni hypothetical protein 0.0085 0.048 0.0503
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0166 0.0242
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.006 0.0459
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.2654 0.3864
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.048 0.0698
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0688 0.1033
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni amine GPCR 0.0085 0.048 0.0503
Trichomonas vaginalis set domain proteins, putative 0.0493 0.3027 0.3024
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus granulosus hypothetical protein 0.0761 0.4705 0.6849
Mycobacterium ulcerans hydrolase 0.0009 0.0007 0.0003
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0063 0.0066
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0404 0.2473 0.36
Echinococcus granulosus cpg binding protein 0.0032 0.0149 0.0216
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0166 0.0205
Echinococcus multilocularis cpg binding protein 0.0032 0.0149 0.0216
Mycobacterium tuberculosis Probable sulfatase 0.0009 0.0007 0.0004
Schistosoma mansoni lamin 0.0056 0.0298 0.0312
Echinococcus granulosus dro:myosuppressin receptor 0.0085 0.048 0.0698
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1108 0.6869 0.7201
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Leishmania major glycosyl hydrolase-like protein 0.0013 0.0029 0.0003
Echinococcus granulosus neuropeptide FF receptor 2 0.0085 0.048 0.0698
Echinococcus granulosus expressed protein 0.0009 0.0004 0.0006
Schistosoma mansoni alpha glucosidase 0.0035 0.0166 0.0174
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0079 0.0083
Echinococcus granulosus sex peptide receptor 0.0085 0.048 0.0698
Brugia malayi hypothetical protein 0.0021 0.0079 0.0115
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1108 0.6869 0.7201
Schistosoma mansoni amine GPCR 0.0085 0.048 0.0503
Schistosoma mansoni hypothetical protein 0.0085 0.048 0.0503
Onchocerca volvulus 0.0085 0.048 0.1567
Treponema pallidum NADH oxidase 0.0018 0.006 0.0816
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0029 0.0025
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0085 0.048 0.0503
Schistosoma mansoni hypothetical protein 0.0085 0.048 0.0503
Echinococcus granulosus lamin dm0 0.0056 0.0298 0.0434
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0079 0.0083
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0077 0.0073
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0149 0.0472
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.048 0.0503
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0166 0.0148
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0079 0.0115
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0693 0.1009
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0161
Loa Loa (eye worm) hypothetical protein 0.0031 0.0144 0.021
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0085 0.048 0.0503
Echinococcus multilocularis carbonic anhydrase 0.0488 0.2997 0.4363
Schistosoma mansoni ferritin light chain 0.0009 0.0004 0.0004
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0166 0.0163
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0166 0.0242
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0166 0.0163
Schistosoma mansoni biogenic amine receptor 0.0085 0.048 0.0503
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0029 0.0025
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0149 0.0472
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0207 0.1239 0.1803
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1108 0.6869 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0079 0.0115
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.089 0.5509 0.802
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0079 0.0115
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0079 0.0115
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0021 0.0031
Echinococcus multilocularis G protein coupled receptor 139 0.0085 0.048 0.0698
Mycobacterium ulcerans carbonic anhydrase 0.1535 0.954 0.954
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0166 0.0148
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0488 0.2997 0.4363
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Echinococcus granulosus G protein coupled receptor 139 0.0085 0.048 0.0698
Schistosoma mansoni hypothetical protein 0.0031 0.0144 0.0151
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0085 0.048 0.0698
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0021 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0079 0.0083
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0076 0.0228
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.048 0.0698
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0079 0.0115
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0029 0.0025
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0085 0.048 0.0503
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0085 0.048 0.0503
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0085 0.048 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0079 0.0075
Loa Loa (eye worm) hypothetical protein 0.0404 0.2473 0.36
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0079 0.0075
Brugia malayi CXXC zinc finger family protein 0.003 0.0138 0.0201
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0272 0.0396
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0166 0.0148
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1108 0.6869 1
Echinococcus multilocularis fmrfamide receptor 0.0085 0.048 0.0698
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.006 0.3754
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0021 0.0022
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0094 0.009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0077 0.011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0085 0.048 0.0698
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0007 0.0004
Loa Loa (eye worm) glutathione reductase 0.0052 0.0272 0.0396
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0569 0.0828
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0166 0.0163
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Onchocerca volvulus 0.0085 0.048 0.1567
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0079 0.0115
Loa Loa (eye worm) hypothetical protein 0.0063 0.0339 0.0494
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0693 0.0727
Echinococcus granulosus carbonic anhydrase II 0.1108 0.6869 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.077 0.1158
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0079 0.0115
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.006 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0079 0.0075
Schistosoma mansoni carbonic anhydrase 0.1535 0.954 1
Toxoplasma gondii thioredoxin reductase 0.0052 0.0272 0.0883
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus granulosus 7tm_1 domain containing protein 0.0085 0.048 0.0698
Echinococcus granulosus neuropeptide receptor 0.0085 0.048 0.0698
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0693 0.069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0077 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0085 0.048 0.0698
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.048 0.0698
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.006 0.005
Onchocerca volvulus 0.003 0.0138 0.0434
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0166 0.0242
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0012
Schistosoma mansoni neuropeptide receptor 0.0085 0.048 0.0503
Toxoplasma gondii hypothetical protein 0.0488 0.2997 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0079 0.0115
Onchocerca volvulus 0.0493 0.3027 1
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Brugia malayi neuropeptide F receptor 0.0085 0.048 0.0698
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1028 0.1024
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0149 0.0472
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Onchocerca volvulus 0.0085 0.048 0.1567
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.151 0.1506
Schistosoma mansoni microtubule-associated protein tau 0.0758 0.468 0.4906
Echinococcus multilocularis neuropeptides capa receptor 0.0085 0.048 0.0698
Schistosoma mansoni ferritin light chain 0.0009 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0031 0.0144 0.0151
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0009 0.001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0085 0.048 0.0503
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0454 0.2784 0.4053
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0149 0.0145
Schistosoma mansoni carbonic anhydrase 0.0488 0.2997 0.3142
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0029 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Brugia malayi G protein-coupled receptor F59B2.13 0.0085 0.048 0.0698
Entamoeba histolytica hypothetical protein 0.0021 0.0079 0.0056
Brugia malayi putative neuropeptide receptor 0.0085 0.048 0.0698
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1068 0.662 1
Entamoeba histolytica hypothetical protein 0.0021 0.0079 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0029 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0149 0.0145
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.077 0.1158
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0021 0.0031
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0085 0.048 0.0698
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.006 0.7722
Echinococcus multilocularis carbonic anhydrase II 0.1108 0.6869 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0149 0.0145
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0079 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0117 0.017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0339 0.0356
Onchocerca volvulus 0.0085 0.048 0.1567
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.006 0.0036
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0085 0.048 0.0698
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0009 0.0007 0.0003
Onchocerca volvulus 0.0085 0.048 0.1567
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0079 0.0115
Brugia malayi follicle stimulating hormone receptor 0.0338 0.2057 0.2995
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.048 0.0503
Onchocerca volvulus 0.0085 0.048 0.1567
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0085 0.048 0.0698
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0079 0.0083
Toxoplasma gondii exonuclease III APE 0.0021 0.0077 0.0229
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0135 0.0197
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0085 0.048 0.0698
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Onchocerca volvulus 0.0091 0.0518 0.1692
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0079 0.0083
Echinococcus multilocularis microtubule associated protein 2 0.0758 0.468 0.6814
Schistosoma mansoni apoferritin-2 0.0009 0.0004 0.0004
Schistosoma mansoni alpha-1 adrenergic receptor 0.0085 0.048 0.0503
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0077 0.4919
Schistosoma mansoni myosin xvIII 0.0085 0.048 0.0503
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0693 0.0701
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0693 0.1009
Brugia malayi 6-phosphofructokinase 0.0119 0.0693 0.1009
Brugia malayi Serotonin receptor 0.0085 0.048 0.0698
Echinococcus granulosus biogenic amine 5HT receptor 0.0481 0.2952 0.4297
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.006 0.005
Schistosoma mansoni amine GPCR 0.0085 0.048 0.0503
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0339 0.0494
Onchocerca volvulus 0.0085 0.048 0.1567
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus granulosus somatostatin receptor 0.0085 0.048 0.0698
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0008 0.0012
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0079 0.0115
Echinococcus granulosus neuropeptides capa receptor 0.0085 0.048 0.0698
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0029 0.0005
Schistosoma mansoni biogenic amine receptor 0.0085 0.048 0.0503
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0693 1
Echinococcus granulosus neuropeptide receptor A26 0.0085 0.048 0.0698
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0079 0.0115
Echinococcus multilocularis orexin receptor type 2 0.0085 0.048 0.0698
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0009 0.0014
Brugia malayi ORL1-like opioid receptor 0.0085 0.048 0.0698
Echinococcus granulosus GPCR family 2 0.0031 0.0144 0.021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0085 0.048 0.0503
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni hypothetical protein 0.0488 0.2997 0.3142
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.151 0.1506
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1108 0.6869 1
Brugia malayi Melatonin receptor type 1A 0.0085 0.048 0.0698
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0021 0.003
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0488 0.2997 0.4363
Schistosoma mansoni amine GPCR 0.0085 0.048 0.0503
Mycobacterium ulcerans sulfatase 0.0009 0.0007 0.0003
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0693 0.0723
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0009 0.0007 0.0003
Echinococcus multilocularis GPCR, family 2 0.0031 0.0144 0.021
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0085 0.048 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0117 0.017
Brugia malayi Dopamine receptor protein 1 0.0085 0.048 0.0698
Echinococcus multilocularis serotonin receptor 0.0481 0.2952 0.4297
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0339 0.0356
Schistosoma mansoni carbonic anhydrase-related 0.0488 0.2997 0.3142
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0569 0.0828
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0008 0.0012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.006 0.005
Brugia malayi putative neuropeptide receptor NPR1 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0055 0.0291 0.0424
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0079 0.0115
Echinococcus multilocularis neuropeptide receptor 0.0085 0.048 0.0698
Plasmodium falciparum thioredoxin reductase 0.0018 0.006 0.0174
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0079 0.0075
Brugia malayi Thioredoxin reductase 0.0052 0.0272 0.0396
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus granulosus intermediate filament protein 0.0056 0.0298 0.0434
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0079 0.0083
Loa Loa (eye worm) hypothetical protein 0.0488 0.2997 0.4363
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0144 0.021
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0085 0.048 0.1567
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.151 0.2198
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0481 0.2952 0.4297
Brugia malayi Sulfatase family protein 0.0009 0.0007 0.001
Echinococcus granulosus neuropeptide s receptor 0.0085 0.048 0.0698
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0272 0.0405
Echinococcus granulosus fmrfamide receptor 0.0085 0.048 0.0698
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0933 0.1358
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0009 0.0007 0.0004
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0079 0.0115
Schistosoma mansoni carbonic anhydrase-related 0.0488 0.2997 0.3142
Schistosoma mansoni DNA helicase recq5 0.001 0.0008 0.0009
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0149 0.2108
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Schistosoma mansoni hypothetical protein 0.0031 0.0144 0.0151
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0488 0.2997 0.4363
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0026 0.0022
Brugia malayi Tachykinin-like peptides receptor 99D 0.0085 0.048 0.0698
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.006 0.0174
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0224 0.0235
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0166 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Echinococcus granulosus orexin receptor type 2 0.0085 0.048 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Brugia malayi RE15519p 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0166 0.0242
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0079 0.0115
Echinococcus granulosus ferritin 0.0009 0.0004 0.0006
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0085 0.048 0.0698
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.048 0.0698
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0149 0.0472
Echinococcus multilocularis neuropeptide FF receptor 2 0.0085 0.048 0.0698
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.005
Schistosoma mansoni alpha-glucosidase 0.0136 0.0796 0.0834
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0488 0.2997 0.4363
Trypanosoma brucei trypanothione reductase 0.0052 0.0272 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Brugia malayi G protein-coupled receptor 0.0085 0.048 0.0698
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0166 0.0163
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0085 0.048 0.0698
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni ap endonuclease 0.0021 0.0077 0.0081
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0103 0.015
Echinococcus granulosus expressed protein 0.041 0.2508 0.3651
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0077 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.0167 0.0244
Echinococcus granulosus lamin 0.0056 0.0298 0.0434
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0077 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0079 0.0083
Onchocerca volvulus 0.0063 0.0339 0.1102
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus granulosus carbonic anhydrase 0.0488 0.2997 0.4363
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.048 0.0698
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0077 0.0112
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0077 0.1026
Loa Loa (eye worm) TYRA-2 protein 0.0085 0.048 0.0698
Onchocerca volvulus 0.0085 0.048 0.1567
Brugia malayi GnHR receptor homolog 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0056 0.0298 0.0434
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0166 0.0163
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0079 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.1609 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0085 0.048 0.0698
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0201 0.0292
Echinococcus multilocularis musashi 0.0056 0.0298 0.0434
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0115
Echinococcus granulosus bloom syndrome protein 0.0023 0.0094 0.0137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0339 0.1108
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0166 0.0529
Brugia malayi AKH receptor 0.0085 0.048 0.0698
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0085 0.048 0.0698
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.006 0.0174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0144 0.021
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.006 0.0056
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0693 0.069
Brugia malayi PXA domain containing protein 0.0021 0.0079 0.0115
Echinococcus multilocularis neuropeptide s receptor 0.0085 0.048 0.0698
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.00000000009205
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0693 0.1042
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0079 0.0115
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0079 0.0075
Schistosoma mansoni DNA helicase recq1 0.001 0.0008 0.0009
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0079 0.0083
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.006 0.0088
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0085 0.048 0.0698
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0149 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0144 0.021
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0693 0.1009
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Schistosoma mansoni neuropeptide receptor 0.0085 0.048 0.0503
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0693 0.0701
Brugia malayi Pre-SET motif family protein 0.0063 0.0339 0.0494
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0077 0.0073
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.006 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0973 0.3198
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0688 0.1033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0085 0.048 0.0698
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0077 0.0074
Entamoeba histolytica carbonic anhydrase, putative 0.1535 0.954 1
Onchocerca volvulus 0.0085 0.048 0.1567
Schistosoma mansoni opsin-like receptor 0.0085 0.048 0.0503
Brugia malayi Dopamine receptor protein 2 0.0085 0.048 0.0698
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1108 0.6869 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0149 0.35
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0149 0.0472
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.048 0.0698
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0077 0.0053
Echinococcus granulosus g protein coupled receptor 0.0085 0.048 0.0698
Echinococcus multilocularis carbonic anhydrase 0.0488 0.2997 0.4363
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0079 0.0115
Echinococcus multilocularis expressed protein 0.041 0.2508 0.3651
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Onchocerca volvulus 0.0085 0.048 0.1567
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.002 0.0029
Echinococcus multilocularis g-protein coupled receptor 0.0085 0.048 0.0698
Schistosoma mansoni biogenic amine receptor 0.0085 0.048 0.0503
Schistosoma mansoni apoferritin-2 0.0009 0.0004 0.0004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.006 0.0056
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0079 0.0115
Echinococcus granulosus microtubule associated protein 2 0.0758 0.468 0.6814
Mycobacterium tuberculosis Possible hydrolase 0.0009 0.0007 0.0004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Echinococcus multilocularis allatostatin A receptor 0.0085 0.048 0.0698
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0321 0.0467
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.006 0.0056
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0085 0.048 0.0503
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Plasmodium falciparum thioredoxin reductase 0.0052 0.0272 0.0883
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0272 0.0396
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0094 0.009
Plasmodium falciparum glutathione reductase 0.0018 0.006 0.0174
Echinococcus granulosus neuropeptide Y receptor 0.0085 0.048 0.0698
Trypanosoma brucei carbonic anhydrase-like protein 0.1108 0.6869 1
Brugia malayi G-protein coupled receptor 0.0085 0.048 0.0698
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0693 0.069
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0079 0.0115
Loa Loa (eye worm) melatonin receptor type 1A 0.0085 0.048 0.0698
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0339 0.0356
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0339 0.0494
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0714 0.1039
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0029 0.0043
Brugia malayi MH2 domain containing protein 0.0123 0.0714 0.1039
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0339 0.0494
Loa Loa (eye worm) hypothetical protein 0.0099 0.0569 0.0828
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.077 0.1158
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0201 0.0292
Brugia malayi 6-phosphofructokinase 0.0119 0.0693 0.1009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0144 0.021
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0693 0.069
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0373 0.0542
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0079 0.0115
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0115
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.048 0.0698
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0008 0.0012
Echinococcus granulosus allatostatin A receptor 0.0085 0.048 0.0698
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.048 0.0503
Echinococcus granulosus tm gpcr rhodopsin 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Mycobacterium ulcerans arylsulfatase AtsB 0.0009 0.0007 0.0003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.006 0.0459
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.048 0.0698
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0079 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.006 0.0063
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0079 0.0083
Brugia malayi G-protein coupled receptor 0.0085 0.048 0.0698
Leishmania major trypanothione reductase 0.0052 0.0272 0.0259
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni opsin-like receptor 0.0085 0.048 0.0503
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0322 0.105
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.048 0.0503
Loa Loa (eye worm) RecQ helicase 0.0023 0.0094 0.0137
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0149 0.013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Plasmodium falciparum glutathione reductase 0.0052 0.0272 0.0883
Onchocerca volvulus 0.0085 0.048 0.1567
Loa Loa (eye worm) hypothetical protein 0.0481 0.2952 0.4297
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.151 0.1506
Schistosoma mansoni hypothetical protein 0.0085 0.048 0.0503
Echinococcus granulosus carbonic anhydrase 0.0488 0.2997 0.4363
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0149 0.0145
Onchocerca volvulus 0.0085 0.048 0.1567
Loa Loa (eye worm) G-protein coupled receptor 0.0085 0.048 0.0698
Schistosoma mansoni neuropeptide f receptor 76f 0.0085 0.048 0.0503
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0079 0.0115
Echinococcus granulosus neuropeptide receptor 0.0085 0.048 0.0698
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0085 0.048 0.0698
Echinococcus multilocularis g protein coupled receptor 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.001
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0714 0.1039
Echinococcus granulosus alpha 1A adrenergic receptor 0.0085 0.048 0.0698
Schistosoma mansoni lamin 0.0056 0.0298 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.1609 1 1
Entamoeba histolytica hypothetical protein 0.0021 0.0079 0.0056
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1028 0.1024
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0338 0.2057 0.2995
Echinococcus granulosus dnaJ subfamily B 0.0433 0.2654 0.3864
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0298 0.0434
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0029 0.0025
Brugia malayi hypothetical protein 0.0021 0.0079 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0693 0.0975
Schistosoma mansoni neuropeptide F-like receptor 0.0085 0.048 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0079 0.0115
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni cpg binding protein 0.0032 0.0149 0.0156
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0688 0.1033
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0488 0.2997 0.4363
Echinococcus granulosus g-protein coupled receptor 0.0085 0.048 0.0698
Leishmania major C-8 sterol isomerase-like protein 0.0404 0.2473 0.2572
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0433 0.2654 0.3863
Schistosoma mansoni neuropeptide receptor 0.0085 0.048 0.0503
Loa Loa (eye worm) hypothetical protein 0.0488 0.2997 0.4363
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0029 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0013 0.0029 0.0043
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0272 0.0396
Echinococcus multilocularis conserved hypothetical protein 0.0676 0.4173 0.6075
Schistosoma mansoni intermediate filament proteins 0.0056 0.0298 0.0312
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0166 0.0163
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0693 0.1009
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0027 0.0117 0.017
Echinococcus multilocularis somatostatin receptor 0.0085 0.048 0.0698
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0149 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.005
Echinococcus multilocularis g protein coupled receptor 0.0085 0.048 0.0698
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0021 0.0031
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.006 0.7722
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0094 0.0137
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0933 0.1358
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0079 0.0115
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0138 0.0201
Brugia malayi PXA domain containing protein 0.0021 0.0079 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0365 0.0383
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0008 0.0108
Echinococcus granulosus serotonin receptor 0.0085 0.048 0.0698
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0272 0.036
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0085 0.048 0.0503
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0184 0.018
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0541 0.3328 0.5025
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0021 0.0031
Echinococcus granulosus g protein coupled receptor 0.0085 0.048 0.0698
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0077 0.0074
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0149 0.35
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Plasmodium falciparum carbonic anhydrase 0.0488 0.2997 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0224 0.0235
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0201 0.0292
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0029 0.0025
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0013 0.0029 0.0003
Brugia malayi hypothetical protein 0.0134 0.0783 0.1139
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0085 0.048 0.0698
Loa Loa (eye worm) neuropeptide F receptor 0.0085 0.048 0.0698
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.006 0.0056
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.006 0.0085
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0693 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.006 0.0174
Echinococcus multilocularis expressed protein 0.0009 0.0004 0.0006
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0085 0.048 0.0698
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0298 0.0434
Leishmania major carbonic anhydrase-like protein 0.1108 0.6869 0.7193
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0012
Schistosoma mansoni hypothetical protein 0.0433 0.2654 0.2782
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0144 0.021
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.006 0.005
Onchocerca volvulus 0.0056 0.0298 0.0964
Echinococcus granulosus peptide allatostatin:somatostatin 0.0085 0.048 0.0698
Schistosoma mansoni biogenic amine (5HT) receptor 0.0454 0.2784 0.2919
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0298 0.0434
Brugia malayi sulfakinin receptor protein 0.0085 0.048 0.0698
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0135 0.0197
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0079 0.0115
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0079 0.0115
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0094 0.0137
Schistosoma mansoni hypothetical protein 0.0031 0.0144 0.0151
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0488 0.2997 0.4363
Echinococcus multilocularis lamin dm0 0.0056 0.0298 0.0434
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0079 0.0115
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0693 0.1009
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Brugia malayi Cytochrome P450 family protein 0.0025 0.0103 0.015
Brugia malayi intermediate filament protein 0.0056 0.0298 0.0434
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0021 0.003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0085 0.048 0.0698
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0149 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0144 0.021
Echinococcus multilocularis ferritin 0.0009 0.0004 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0079 0.0075
Schistosoma mansoni neuropeptide receptor 0.0085 0.048 0.0503
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0933 0.1358
Plasmodium vivax SET domain protein, putative 0.0063 0.0339 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Mycobacterium ulcerans arylsulfatase, AslA 0.0009 0.0007 0.0003
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0693 0.0975
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0973 0.0969
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0079 0.0115
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.151 0.1506
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0008 0.0012
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0085 0.048 0.0698
Onchocerca volvulus 0.0085 0.048 0.1567
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Schistosoma mansoni cpg binding protein 0.003 0.0138 0.0144
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.006 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Schistosoma mansoni ap endonuclease 0.0021 0.0077 0.0081
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus multilocularis dro:myosuppressin receptor 0.0085 0.048 0.0698
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0933 0.1358
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0036
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0688 0.1033
Schistosoma mansoni hypothetical protein 0.0068 0.0373 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0166 0.0163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0569 0.0828
Brugia malayi glutathione reductase 0.0052 0.0272 0.0396
Schistosoma mansoni growth hormone secretagogue receptor 0.0085 0.048 0.0503
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0115
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0009 0.0014
Mycobacterium tuberculosis Probable reductase 0.0118 0.0688 0.1033
Brugia malayi phosphofructokinase 0.0119 0.0693 0.1009
Onchocerca volvulus 0.0056 0.0298 0.0964
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni carbonic anhydrase-related 0.0488 0.2997 0.3142
Schistosoma mansoni alpha-glucosidase 0.0136 0.0796 0.0834
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0166 0.0205
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Schistosoma mansoni cpg binding protein 0.0032 0.0149 0.0156
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.003 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0272 0.7699
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0077 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Mycobacterium ulcerans arylsulfatase AtsD 0.0009 0.0007 0.0003
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.006 0.0088
Echinococcus granulosus g protein coupled receptor 0.0085 0.048 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0079 0.0083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0007 0.0003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0688 0.1033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0085 0.048 0.0698
Onchocerca volvulus 0.0085 0.048 0.1567
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0339 0.0356
Schistosoma mansoni histamine h1 receptor 0.0085 0.048 0.0503
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0077 0.0112
Brugia malayi larval opioid receptor 0.0085 0.048 0.0698
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0079 0.0115
Schistosoma mansoni adenoreceptor 0.0085 0.048 0.0503
Trypanosoma brucei C-8 sterol isomerase, putative 0.0404 0.2473 0.3576
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0079 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0144 0.021
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0688 0.0717
Echinococcus granulosus carbonic anhydrase 0.0488 0.2997 0.4363
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0079 0.0075
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0029 0.0075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0085 0.048 0.0503
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0008 0.0012
Leishmania major carbonic anhydrase family protein, putative 0.1535 0.954 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1535 0.954 1
Echinococcus multilocularis sex peptide receptor 0.0085 0.048 0.0698
Echinococcus multilocularis serotonin receptor 0.0481 0.2952 0.4297
Onchocerca volvulus Neuropeptide F receptor homolog 0.0085 0.048 0.1567
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.077 0.0803
Echinococcus granulosus rhodopsin orphan GPCR 0.0085 0.048 0.0698
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0166 0.0163
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0009 0.0014
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0933 0.1358
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.151 0.1506
Brugia malayi hypothetical protein 0.0009 0.0007 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0085 0.048 0.0503
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0404 0.2473 0.3576
Loa Loa (eye worm) hypothetical protein 0.0085 0.048 0.0698
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0013 0.0029 0.0005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.006 0.0036
Echinococcus multilocularis carbonic anhydrase 0.0488 0.2997 0.4363
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0085 0.048 0.0698
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0184 0.018
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0201 0.0292
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0085 0.048 0.0698
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0079 0.0115
Brugia malayi neuropeptide F receptor 0.0085 0.048 0.0698
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.003 0.0044
Plasmodium vivax glutathione reductase, putative 0.0052 0.0272 0.7699
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0079 0.0115
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.151 0.2198
Schistosoma mansoni amine GPCR 0.0085 0.048 0.0503
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0085 0.048 0.0698
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0693 0.0701
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0693 0.0727
Onchocerca volvulus 0.0085 0.048 0.1567
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.0161
Echinococcus granulosus tachykinin peptides receptor 99D 0.0085 0.048 0.0698
Loa Loa (eye worm) carbonic anhydrase 3 0.1108 0.6869 1
Schistosoma mansoni ferritin 0.0009 0.0004 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0085 0.048 0.0698
Brugia malayi hypothetical protein 0.0085 0.048 0.0698
Echinococcus multilocularis fmrfamide receptor 0.0085 0.048 0.0698
Echinococcus multilocularis lamin 0.0056 0.0298 0.0434
Loa Loa (eye worm) hypothetical protein 0.0068 0.0373 0.0542
Onchocerca volvulus 0.0085 0.048 0.1567

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 230 nM Antiviral activity against HCV in human Huh7 cells after 72 hrs by cell based luciferase reporter assay ChEMBL. 18448339
IC50 (binding) < 3 nM Inhibition of HCV NS3 protease ChEMBL. 18448339

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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