Detailed information for compound 514873

Basic information

Technical information
  • TDR Targets ID: 514873
  • Name: 5-methylpyrido[4,3-b]indole
  • MW: 182.221 | Formula: C12H10N2
  • H donors: 0 H acceptors: 1 LogP: 2.27 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cn1c2ccncc2c2c1cccc2
  • InChi: 1S/C12H10N2/c1-14-11-5-3-2-4-9(11)10-8-13-7-6-12(10)14/h2-8H,1H3
  • InChiKey: OSJLOPGPFMIKTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Echinococcus granulosus smad 0.0009 0.0004 0.0003
Schistosoma mansoni regulator of G protein signaling 0.001 0.0005 0.0005
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.0334 0.0334
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0031 0.0039 0.0096
Onchocerca volvulus Cell death protein 3 homolog 0.0035 0.0045 0.1168
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0001 0.0001
Brugia malayi beta-lactamase 0.0041 0.0054 0.0134
Schistosoma mansoni dishevelled 0.001 0.0005 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0001 0.0001
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0004 0.0003
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0001 0.0001
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0005 0.0005
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0157 0.0242 0.628
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0008
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0001 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0001 0.0001
Treponema pallidum hypothetical protein 0.0157 0.0242 0.5
Loa Loa (eye worm) beta-lactamase 0.0041 0.0054 0.0054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0157 0.0242 0.0241
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0001 0.0001
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0008
Onchocerca volvulus 0.0246 0.0385 1
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0039 0.0038
Onchocerca volvulus 0.0035 0.0045 0.1168
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0001 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0142 0.0142
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0142 0.0142
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0001 0.0001
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0001 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0142 0.0142
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0004 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0242 0.1375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0001 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0001 0.0001
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0054 0.0306
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0001 0.0001
Trichomonas vaginalis esterase, putative 0.0041 0.0054 0.0306
Plasmodium falciparum cation/H+ antiporter 0.0157 0.0242 0.5
Brugia malayi DIX domain containing protein 0.001 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0054
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0157 0.0242 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0142 0.0142
Loa Loa (eye worm) solute carrier family 8 0.6225 1 1
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0001 0.0001
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0157 0.0242 0.0241
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0054 0.5
Brugia malayi Sodium/calcium exchanger protein 0.249 0.3994 1
Brugia malayi steroid hormone receptor 0.0007 0.0001 0.0001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0142 0.0142
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0004
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0089 0.0088
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0001 0.0001
Echinococcus multilocularis apoptotic protease activating factor 1 0.0035 0.0045 0.0045
Schistosoma mansoni dep domain containing protein 0.001 0.0005 0.0005
Schistosoma mansoni caspase-7 (C14 family) 0.0035 0.0045 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0039 0.0039
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0005 0.0012
Schistosoma mansoni hypothetical protein 0.0028 0.0034 0.0034
Brugia malayi N-terminal motif family protein 0.0204 0.0318 0.0794
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0001 0.0001
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0157 0.0242 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0054
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0089 0.0088
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0054 0.0306
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0054 0.0134
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0039 0.1424
Brugia malayi hypothetical protein 0.001 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi nuclear hormone receptor 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0157 0.0242 0.0241
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0005 0.0005
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0331 0.0522 0.0522
Schistosoma mansoni sodium/calcium exchanger 0.6225 1 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0004 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0142 0.0142
Onchocerca volvulus 0.001 0.0005 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0054 0.0756
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0206 0.0206
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0001 0.0001
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0005 0.0005
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0157 0.0242 0.0242
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0005 0.0005
Echinococcus multilocularis sodium calcium exchanger 0.6225 1 1
Echinococcus multilocularis smad 0.0009 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0001 0.0001
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0037 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0001 0.0001
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0157 0.0242 0.0241
Schistosoma mansoni dishevelled 0.001 0.0005 0.0005
Brugia malayi mbt repeat family protein 0.0055 0.0077 0.0191
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0004 0.0003
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0089 0.0089
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0001 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0001 0.0001
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0077 0.0076
Mycobacterium ulcerans lipase LipD 0.0041 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.0337 0.0336
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0157 0.0242 0.0604
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0077 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0001 0.0001
Mycobacterium ulcerans beta-lactamase 0.0041 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0157 0.0242 0.0241
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0157 0.0242 0.5337
Brugia malayi ecdysteroid receptor 0.0007 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0009 0.0004 0.0008
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0005 0.0012
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0004 0.0003
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.249 0.3994 0.3993
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0077 0.0077
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi nuclear receptor NHR-88 0.0007 0.0001 0.0001
Onchocerca volvulus 0.0055 0.0077 0.1983
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0157 0.0242 0.0241
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0005 0.0005
Echinococcus multilocularis Smad4 0.0009 0.0004 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0142 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0001 0.0001
Echinococcus granulosus caspase 2 0.0035 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0039 0.0038
Brugia malayi hypothetical protein 0.001 0.0005 0.0012
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0077 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0054 0.0306
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0001 0.0001
Mycobacterium ulcerans hypothetical protein 0.0041 0.0054 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0005 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0001 0.0001
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0005 0.0005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0077 0.1983
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0077 0.0076
Schistosoma mansoni coup transcription factor 0.0007 0.0001 0.0001
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0001 0.0001
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0157 0.0242 0.0604
Onchocerca volvulus 0.0031 0.0039 0.0998
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0001 0.0001
Brugia malayi Pre-SET motif family protein 0.0216 0.0337 0.0842
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0001 0.0001
Brugia malayi hypothetical protein 0.0035 0.0045 0.0112
Loa Loa (eye worm) hypothetical protein 0.0055 0.0077 0.0076
Schistosoma mansoni na/ca exchanger 0.0157 0.0242 0.0242
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0001 0.0001
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0135 0.0206 0.0515
Loa Loa (eye worm) hypothetical protein 0.0571 0.0907 0.0906
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0039 0.0039
Echinococcus granulosus Smad4 0.0009 0.0004 0.0003
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0005 0.0005
Onchocerca volvulus 0.0041 0.0054 0.1397
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0054 0.5
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0077 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0054 0.0306
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0039 0.0038
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0001 0.0001
Loa Loa (eye worm) MBCTL1 0.0062 0.0089 0.0088
Brugia malayi mbt repeat family protein 0.0055 0.0077 0.0191
Toxoplasma gondii ABC1 family protein 0.0041 0.0054 0.2073
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0259 0.0406 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0005 0.0012
Brugia malayi Cell death protein 3 precursor 0.0035 0.0045 0.0112
Brugia malayi small heat shock protein 0.0571 0.0907 0.227
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0004 0.0003
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0089 0.0088
Brugia malayi beta-lactamase family protein 0.0041 0.0054 0.0134
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0005 0.0121
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0039 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0001 0.0001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0001 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0001 0.0001
Onchocerca volvulus 0.0041 0.0054 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0242 0.1375
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0001 0.0001
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.0334 0.0334
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0206 0.0206
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0001 0.0001
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0077 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0054 0.0306
Toxoplasma gondii manganese resistance 1 protein, putative 0.0157 0.0242 1
Plasmodium vivax cation/H+ antiporter, putative 0.0157 0.0242 1
Brugia malayi Smad1 0.0009 0.0004 0.0008
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0005 0.0005
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0001 0.0001
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0001 0.0001
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0001 0.0001
Echinococcus granulosus apoptotic protease activating factor 1 0.0035 0.0045 0.0045
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1098 0.1755 1
Leishmania major hypothetical protein, conserved 0.0041 0.0054 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0054 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0054 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0039 0.0039
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0089 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0001 0.0001
Schistosoma mansoni smad 0.0009 0.0004 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0039 0.0038
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0001 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0001 0.0001
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0005 0.0005
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.0318 0.8253
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0005
Echinococcus multilocularis caspase 2 0.0035 0.0045 0.0045
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0157 0.0242 0.0242
Loa Loa (eye worm) Smad1 0.0009 0.0004 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0054 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0001 0.0001
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0157 0.0242 0.0241
Schistosoma mansoni hypothetical protein 0.0157 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0054
Onchocerca volvulus 0.0041 0.0054 0.1397
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0001 0.0001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0001 0.0014
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0005 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0054 0.5
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0089 0.0221
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0035 0.0045 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0054 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0142 0.0142
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0242 0.1375
Trichomonas vaginalis set domain proteins, putative 0.0246 0.0385 0.2189
Schistosoma mansoni hypothetical protein 0.0035 0.0045 0.0045
Brugia malayi MH1 domain containing protein 0.0009 0.0004 0.0008
Trichomonas vaginalis alpha-L-fucosidase, putative 0.1098 0.1755 1
Schistosoma mansoni smad1 5 8 and 0.0009 0.0004 0.0004
Brugia malayi beta-lactamase family protein 0.0041 0.0054 0.0134
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0157 0.0242 0.0241
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0001 0.0001
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0204 0.0318 0.0317
Loa Loa (eye worm) hypothetical protein 0.0041 0.0054 0.0054
Schistosoma mansoni Smad4 0.0009 0.0004 0.0004
Onchocerca volvulus 0.0007 0.0001 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0142 0.0142
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 29 uM Cytotoxicity against mock-infected MDBK cells by LDH method ChEMBL. 18289862
EC50 (functional) = 0.26 uM Antiviral activity against BVDV infected in MDBK cells assessed as reduction in viral induced cell destruction by MTT assay ChEMBL. 18289862
Ratio CC50/EC50 (functional) = 111.5 Selectivity index, ratio of CC50 for MDBK cells to EC50 for BVDV infected in MDBK cells ChEMBL. 18289862

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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