TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 448.726 | Formula: C22H16Cl3NO3
H donors: 1 H acceptors: 2 LogP: 5.74 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(c2ccccc2Cl)c2c(c1)N(C(=O)C(C2)O)c1c(Cl)cccc1Cl
InChi: 1S/C22H16Cl3NO3/c1-29-12-9-14(13-5-2-3-6-16(13)23)15-11-20(27)22(28)26(19(15)10-12)21-17(24)7-4-8-18(21)25/h2-10,20,27H,11H2,1H3
InChiKey: AHEUOGKHUTTYGP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mitogen-activated protein kinase 14	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Brugia malayi	P38 map kinase family protein 2	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma congolense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania donovani	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania mexicana	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania braziliensis	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Schistosoma japonicum	ko:K04441 p38 MAP kinase, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma brucei gambiense	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus granulosus	mitogen activated protein kinase 11	Get druggable targets OG5_128610	All targets in OG5_128610
Candida albicans	MAP kinase involved in osmoregulation	Get druggable targets OG5_128610	All targets in OG5_128610
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	Get druggable targets OG5_128610	All targets in OG5_128610
Echinococcus multilocularis	mitogen activated protein kinase 14	Get druggable targets OG5_128610	All targets in OG5_128610

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 14	360 aa	336 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	membrane bound transcription factor site 1	0.0009	0.02	0.0395
Loa Loa (eye worm)	Notch2	0.0008	0.0173	0.0173
Brugia malayi	olfactory channel protein osm-9	0.0004	0.0009	0.0009
Toxoplasma gondii	subtilisin SUB7	0.0009	0.02	1
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0152	0.5054	0.5054
Echinococcus multilocularis	fibropellin Ia	0.0008	0.0173	0.0343
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Trypanosoma brucei	subtilisin peptidase	0.0009	0.02	0.0395
Onchocerca volvulus		0.0008	0.0173	0.0825
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.02	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0065	0.2099	0.2099
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0009	0.02	0.02
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Onchocerca volvulus	Slit protein homolog	0.0008	0.0173	0.0825
Brugia malayi	Cadherin domain containing protein	0.0008	0.0173	0.0173
Trypanosoma cruzi	subtilisin peptidase	0.0009	0.02	0.0395
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0152	0.5054	1
Brugia malayi	Muscle positioning protein 4	0.0008	0.0173	0.0173
Loa Loa (eye worm)	proprotein convertase 2	0.0009	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Mycobacterium leprae	Possible secreted protease	0.0009	0.02	0.5
Brugia malayi	P38 map kinase family protein 2	0.0152	0.5054	0.5054
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0009	0.02	0.5
Echinococcus granulosus	calcium activated potassium channel	0.0004	0.0019	0.0037
Brugia malayi	Animal haem peroxidase family protein	0.0065	0.2099	0.2099
Echinococcus granulosus	mitogen activated protein kinase 11	0.0152	0.5054	1
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus multilocularis	neurogenic locus notch protein	0.0008	0.0173	0.0343
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Brugia malayi	Peroxidasin	0.0065	0.2099	0.2099
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0008	0.0173	0.0825
Onchocerca volvulus		0.0008	0.0173	0.0825
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Onchocerca volvulus		0.0008	0.0173	0.0825
Echinococcus multilocularis	calcium activated potassium channel	0.0004	0.0019	0.0037
Schistosoma mansoni	furin-1 (S08 family)	0.0009	0.02	0.02
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Schistosoma mansoni	notch	0.0008	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Brugia malayi	neuroendocrine convertase 1 precursor	0.0009	0.02	0.02
Onchocerca volvulus	Neurogenic locus notch homolog	0.0009	0.0182	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Onchocerca volvulus	Peroxidase homolog	0.0065	0.2099	1
Onchocerca volvulus		0.0008	0.0173	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Brugia malayi	Cadherin domain containing protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Onchocerca volvulus		0.0065	0.2099	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.02	1
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0009	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0003	0.000000057993	0.000000057993
Loa Loa (eye worm)	endoprotease bli-4	0.0009	0.02	0.02
Echinococcus multilocularis	neuroendocrine convertase 2	0.0009	0.02	0.0395
Echinococcus granulosus	notch	0.0008	0.0173	0.0343
Echinococcus multilocularis	neurogenic locus notch protein	0.0008	0.0173	0.0343
Brugia malayi	Animal haem peroxidase family protein	0.0065	0.2099	0.2099
Brugia malayi	Delta serrate ligand family protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Echinococcus granulosus	protein jagged 2	0.0008	0.0173	0.0343
Schistosoma mansoni	cell polarity protein	0.0008	0.0173	0.0173
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0009	0.02	0.0395
Toxoplasma gondii	subtilisin SUB10	0.0009	0.02	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0008	0.0173	0.0343
Echinococcus granulosus	furin	0.0009	0.02	0.0395
Plasmodium falciparum	subtilisin-like protease 2	0.0009	0.02	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Brugia malayi	Blistered cuticle protein 3	0.0065	0.2099	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Giardia lamblia	High cysteine protein	0.0008	0.0173	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Echinococcus multilocularis	transient receptor potential cation channel	0.0003	0.000000057993	0.00000011474
Echinococcus granulosus	fibropellin Ia	0.0008	0.0173	0.0343
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0298	1	1
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0009	0.02	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Plasmodium falciparum	subtilisin-like protease 1	0.0009	0.02	0.5
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0009	0.02	0.02
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0009	0.02	0.5
Schistosoma mansoni	notch	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Brugia malayi	celfurPC protein	0.0009	0.02	0.02
Echinococcus granulosus	delta-like protein 1	0.0008	0.0173	0.0343
Echinococcus multilocularis	protein jagged 2	0.0008	0.0173	0.0343
Leishmania major	subtilisin-like serine peptidase	0.0009	0.02	0.0395
Plasmodium vivax	subtilisin-like serine protease, putative	0.0009	0.02	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Schistosoma mansoni	septate junction protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Plasmodium vivax	subtilisin-like protease 2, putative	0.0009	0.02	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.02	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Echinococcus granulosus	neurogenic locus notch protein	0.0008	0.0173	0.0343
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Echinococcus multilocularis	protein jagged 1	0.0008	0.0173	0.0343
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Loa Loa (eye worm)	animal heme peroxidase	0.0065	0.2099	0.2099
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0229	0.0453
Loa Loa (eye worm)	hypothetical protein	0.0009	0.02	0.02
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0008	0.0173	0.0343
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Onchocerca volvulus	Peroxidasin homolog	0.0065	0.2099	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Plasmodium falciparum	subtilisin-like protease 3	0.0009	0.02	0.5
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Brugia malayi	proprotein convertase 2	0.0009	0.02	0.02
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0009	0.02	0.0395
Schistosoma mansoni	transient receptor potential channel	0.0003	0.000000057993	0.000000057993
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0009	0.02	0.0395
Brugia malayi	endoprotease bli-4 precursor	0.0009	0.02	0.02
Schistosoma mansoni	laminin gamma-3 chain	0.0008	0.0173	0.0173
Onchocerca volvulus		0.0065	0.2099	1
Echinococcus multilocularis	neural cadherin	0.0008	0.0173	0.0343
Echinococcus multilocularis	protein jagged 1	0.0008	0.0173	0.0343
Schistosoma mansoni	slit	0.0008	0.0173	0.0173
Toxoplasma gondii	subtilisin SUB2	0.0009	0.02	1
Onchocerca volvulus	Dual oxidase homolog	0.0065	0.2099	1
Loa Loa (eye worm)	POT family protein	0.0088	0.2863	0.2863
Schistosoma mansoni	transient receptor potential channel	0.0003	0.000000057993	0.000000057993
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0111	0.3674	0.7269
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0152	0.5054	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus multilocularis	notch	0.0008	0.0173	0.0343
Toxoplasma gondii	subtilisin SUB5	0.0009	0.02	1
Plasmodium vivax	subtilisin-like protease 1	0.0009	0.02	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Echinococcus multilocularis	slit 2 protein	0.0008	0.0173	0.0343
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Loa Loa (eye worm)	animal heme peroxidase	0.0065	0.2099	0.2099
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Brugia malayi	Animal haem peroxidase family protein	0.0065	0.2099	0.2099
Toxoplasma gondii	subtilisin SUB11	0.0009	0.02	1
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0009	0.02	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0009	0.02	0.0395
Echinococcus granulosus	protein jagged 1	0.0008	0.0173	0.0343
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0009	0.02	0.02
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus multilocularis	Furin 1	0.0009	0.02	0.0395
Brugia malayi	Calcium binding EGF domain containing protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus multilocularis	short transient receptor potential channel 6	0.0004	0.0009	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0009	0.02	0.02
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0009	0.02	0.0395
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0009	0.02	0.02
Brugia malayi	GCC2 and GCC3 family protein	0.0008	0.0173	0.0173
Toxoplasma gondii	subtilisin SUB6	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Schistosoma mansoni	notch	0.0009	0.0182	0.0182
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0009	0.02	0.5
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0008	0.0173	0.0343
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.5054	1
Toxoplasma gondii	subtilisin SUB8	0.0009	0.02	1
Echinococcus granulosus	protein jagged 1	0.0008	0.0173	0.0343
Onchocerca volvulus	Peroxidase homolog	0.0065	0.2099	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus granulosus	neural cadherin	0.0008	0.0173	0.0343
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.5054	1
Schistosoma mansoni	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus multilocularis	neurogenic locus protein delta	0.0008	0.0173	0.0343
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0111	0.3674	0.7269
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Onchocerca volvulus	Chorion peroxidase homolog	0.0065	0.2099	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.02	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.0009	0.0017
Toxoplasma gondii	subtilisin SUB1	0.0009	0.02	1
Loa Loa (eye worm)	animal heme peroxidase	0.0065	0.2099	0.2099
Toxoplasma gondii	EGF family domain-containing protein	0.0008	0.0173	0.867
Onchocerca volvulus	Peroxidasin homolog	0.0065	0.2099	1
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0009	0.0009
Echinococcus granulosus	neuroendocrine convertase 2	0.0009	0.02	0.0395
Onchocerca volvulus		0.0009	0.02	0.0952
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Toxoplasma gondii	subtilisin SUB4	0.0009	0.02	1
Brugia malayi	POT family protein	0.0088	0.2863	0.2863
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0008	0.0173	0.0173
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0009	0.02	0.5
Loa Loa (eye worm)	hypothetical protein	0.0003	0.000000057993	0.000000057993
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Brugia malayi	Animal haem peroxidase family protein	0.0065	0.2099	0.2099
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Schistosoma mansoni	notch	0.0008	0.0173	0.0173
Toxoplasma gondii	subtilisin SUB12	0.0009	0.02	1
Echinococcus granulosus	peroxidasin	0.0065	0.2099	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Onchocerca volvulus		0.0065	0.2099	1
Toxoplasma gondii	subtilisin SUB9	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0152	0.5054	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Brugia malayi	Animal haem peroxidase family protein	0.0065	0.2099	0.2099
Leishmania major	hypothetical protein, conserved	0.001	0.0229	0.0453
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0009	0.02	0.02
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Echinococcus granulosus	neurogenic locus protein delta	0.0008	0.0173	0.0343
Echinococcus granulosus	transient receptor potential cation channel	0.0004	0.0009	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Schistosoma mansoni	peroxidasin	0.0065	0.2099	0.2099
Echinococcus granulosus	protein jagged 2	0.0008	0.0173	0.0343
Onchocerca volvulus	Putative cubilin	0.0008	0.0173	0.0825
Echinococcus multilocularis		0.0009	0.02	0.0395
Echinococcus granulosus	neurogenic locus notch protein	0.0008	0.0173	0.0343
Echinococcus granulosus	Furin 1	0.0009	0.02	0.0395
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0152	0.5054	1
Brugia malayi	hypothetical protein	0.0065	0.2099	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Echinococcus multilocularis	peroxidasin	0.0065	0.2099	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2099	0.2099
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.8123	0.8123
Schistosoma mansoni	peroxidasin	0.0065	0.2099	0.2099
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0009	0.02	0.0395
Echinococcus granulosus	transient receptor potential cation channel	0.0003	0.000000057993	0.00000011474
Echinococcus granulosus	neurogenic locus notch protein 4	0.0008	0.0173	0.0343
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0229	0.0453
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.8123	0.8123
Echinococcus multilocularis	transient receptor potential cation channel	0.0004	0.0009	0.0017
Loa Loa (eye worm)	subtilase	0.0298	1	1
Schistosoma mansoni	notch	0.0008	0.0173	0.0173
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.5054	1
Echinococcus granulosus	mitogen activated protein kinase 14	0.0152	0.5054	1
Brugia malayi	notch-like transmembrane receptor	0.0008	0.0173	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0009	0.02	0.5
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0152	0.5054	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0009	0.02	0.5
Echinococcus granulosus	slit 2 protein	0.0008	0.0173	0.0343
Brugia malayi	Calcium binding EGF domain containing protein	0.0008	0.0173	0.0173
Loa Loa (eye worm)	notch protein	0.0008	0.0173	0.0173
Onchocerca volvulus		0.0008	0.0173	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0173	0.0173
Schistosoma mansoni	notch	0.0008	0.0173	0.0173
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0009	0.02	0.02
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0009	0.02	0.5
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Echinococcus granulosus	transient receptor potential cation channel	0.0003	0.000000057993	0.00000011474
Schistosoma mansoni	transient receptor potential channel	0.0004	0.0009	0.0009
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0008	0.0173	0.0173
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.02	1
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0009	0.02	0.0395
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0008	0.0173	0.0173
Brugia malayi	EGF-like domain containing protein	0.0008	0.0173	0.0173
Loa Loa (eye worm)	animal heme peroxidase	0.0065	0.2099	0.2099
Echinococcus granulosus	short transient receptor potential channel 6	0.0004	0.0009	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 9 nM	Inhibition of p38alpha (unknown origin)	ChEMBL.	18316187
IC50 (binding)	= 9 nM	Inhibition of p38alpha (unknown origin)	ChEMBL.	18316187

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 517318