Detailed information for compound 521572

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 524.031 | Formula: C22H23ClFN5O3S2
  • H donors: 1 H acceptors: 4 LogP: 2.96 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: CN(Cc1nccn1c1ccc(c(c1)F)N1CCC(C1=O)NS(=O)(=O)/C=C/c1ccc(s1)Cl)C
  • InChi: 1S/C22H23ClFN5O3S2/c1-27(2)14-21-25-9-11-28(21)15-3-5-19(17(24)13-15)29-10-7-18(22(29)30)26-34(31,32)12-8-16-4-6-20(23)33-16/h3-6,8-9,11-13,18,26H,7,10,14H2,1-2H3/b12-8+
  • InChiKey: KJUQWLSBEXCOOD-XYOKQWHBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.4933 0.4933
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0835
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0039 0.0522
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0105 0.5245
Loa Loa (eye worm) hypothetical protein 0.0026 0.0247 0.0364
Schistosoma mansoni protein kinase 0.0032 0.0387 0.1159
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.5378
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0015 0.0758
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0044 0.0131
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0344 0.0344
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0484 0.6492
Leishmania major trypanothione reductase 0.0049 0.0746 1
Toxoplasma gondii sugar transporter ST2 0.0015 0.0015 0.0025
Brugia malayi hypothetical protein 0.0245 0.4933 0.7728
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0349 0.0349
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0015 0.0204
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0349 0.0525
Echinococcus multilocularis dna polymerase eta 0.0019 0.0105 0.0105
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0015 0.0015
Echinococcus multilocularis neuropeptide s receptor 0.0483 1 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0396 0.2035
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.0373 0.0373
Echinococcus granulosus GPCR family 2 0.0016 0.0038 0.0038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.2353 1
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0015 0.2439
Onchocerca volvulus Huntingtin homolog 0.0128 0.2429 0.3792
Schistosoma mansoni glucose transport protein 0.0105 0.1944 0.5823
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0038 0.0036
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.0373 0.2053
Schistosoma mansoni methionine-tRNA synthetase 0.0085 0.1516 0.4542
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0105 0.0141
Trypanosoma cruzi hexose transporter 0.0033 0.0396 0.5302
Toxoplasma gondii methionyl-tRNA synthetase 0.0028 0.0289 0.0479
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0044 0.0045
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0044 0.0044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Chlamydia trachomatis methionine--tRNA ligase 0.0085 0.1516 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0062 0.0835
Onchocerca volvulus 0.005 0.0767 0.1182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0171 0.3338 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0062 0.0411
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0396 0.5302
Brugia malayi Bromodomain containing protein 0.003 0.0349 0.0525
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0062 0.1672
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0039 0.0042
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0387 0.042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0045
Echinococcus granulosus Tolloid protein 1 0.0016 0.0044 0.0044
Echinococcus multilocularis peregrin 0.003 0.0349 0.0349
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0015 0.0016
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0062 0.3108
Onchocerca volvulus 0.0313 0.6379 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0044 0.0073
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0015 0.0025
Entamoeba histolytica hypothetical protein 0.0035 0.0456 0.2508
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0349 0.1046
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0105 0.0579
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0387 0.042
Leishmania major glucose transporter, lmgt3 0.0033 0.0396 0.5302
Schistosoma mansoni jumonji domain containing protein 0.0079 0.1389 0.4163
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0015 0.0078
Loa Loa (eye worm) hypothetical protein 0.0032 0.0387 0.0584
Loa Loa (eye worm) hypothetical protein 0.005 0.077 0.1186
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0039 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.141
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.0373 0.0562
Loa Loa (eye worm) hypothetical protein 0.0128 0.2429 0.3792
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0484 0.0525
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0128 0.2429 0.3792
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0387 0.042
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0746 0.0809
Schistosoma mansoni hypothetical protein 0.005 0.0767 0.2298
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.077 0.1186
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0607 0.0607
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0039 0.0117
Echinococcus granulosus dna polymerase eta 0.0019 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0396 0.2035
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0105 0.141
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0044 0.0045
Brugia malayi CHE-14 protein 0.0043 0.0607 0.093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.077 0.1186
Treponema pallidum methionyl-tRNA synthetase 0.0099 0.1816 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0078
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0015 0.0065
Entamoeba histolytica hypothetical protein 0.0038 0.0501 0.2757
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0046
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0387 0.0641
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Brugia malayi Sugar transporter family protein 0.0105 0.1944 0.303
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0105 0.0141
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0396 0.5302
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.141
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0387 0.0584
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0456 0.0456
Echinococcus multilocularis fibrillin 1 0.0016 0.0044 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0835
Plasmodium vivax hypothetical protein, conserved 0.003 0.0349 0.0378
Loa Loa (eye worm) hypothetical protein 0.0032 0.0373 0.0562
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0607 0.0607
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0062 0.0835
Onchocerca volvulus Arrow homolog 0.0016 0.0044 0.0045
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0015 0.0758
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0045
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0484 0.6492
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trypanosoma brucei unspecified product 0.0019 0.0105 0.141
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0387 0.0387
Brugia malayi glutathione reductase 0.0049 0.0746 0.1149
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.2353 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0446 0.9223 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0105 0.0141
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0099 0.1816 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0373 0.1117
Plasmodium falciparum protein kinase 7 0.0297 0.6039 0.6548
Brugia malayi hypothetical protein 0.0128 0.2429 0.3792
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0396 0.5302
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0015 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0039
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.0373 0.0373
Schistosoma mansoni hypothetical protein 0.0041 0.0574 0.172
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0396 0.2035
Toxoplasma gondii sugar transporter ST1 0.0015 0.0015 0.0025
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0484 0.0525
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0387 0.1159
Echinococcus multilocularis laminin 0.0016 0.0044 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0105 0.141
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0039 0.0165
Plasmodium falciparum mitogen-activated protein kinase 2 0.017 0.3326 0.3606
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0387 0.042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.0456 0.2508
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0062 0.0068
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0062 0.3108
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Plasmodium falciparum glutathione reductase 0.0017 0.0062 0.0068
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0015 0.0046
Echinococcus granulosus General substrate transporter 0.009 0.1628 0.1628
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0105 0.141
Brugia malayi Fibulin-1 precursor 0.0016 0.0044 0.0045
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.0373 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Entamoeba histolytica hypothetical protein 0.0035 0.0456 0.2508
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0217
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0015 0.0065
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.2087 0.8868
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trypanosoma brucei sugar transporter, putative 0.0015 0.0015 0.0204
Plasmodium vivax sugar transporter, putative 0.0015 0.0015 0.0016
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.1041 0.1611
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0062 0.0068
Echinococcus granulosus neuropeptide receptor A26 0.0483 1 1
Brugia malayi hypothetical protein 0.0035 0.0456 0.0692
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0062 0.0835
Echinococcus multilocularis geminin 0.0171 0.3338 0.3338
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0039 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0046
Loa Loa (eye worm) multisynthetase complex auxiliary component p43 0.0086 0.1527 0.2376
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0387 0.0641
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0062 0.0103
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0105 0.0541
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0105 0.141
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trypanosoma brucei glucose transporter 1E 0.0033 0.0396 0.5302
Echinococcus multilocularis expressed conserved protein 0.0093 0.1685 0.1685
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0039 0.0522
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0601
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0486 0.0486
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0387 0.0584
Mycobacterium tuberculosis Probable reductase 0.0112 0.2087 0.8868
Plasmodium falciparum hexose transporter 0.0105 0.1944 0.2107
Loa Loa (eye worm) hypothetical protein 0.0052 0.0813 0.1254
Plasmodium falciparum protein kinase 6 0.0446 0.9223 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0062 0.0103
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0396 0.5302
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0078
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0396 0.5302
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0373 0.0562
Echinococcus granulosus dna polymerase kappa 0.0019 0.0105 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.2263 0.3532
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0125 0.0531
Brugia malayi isocitrate dehydrogenase 0.0016 0.0039 0.0037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.077 0.1186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0038 0.0036
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0062 1
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0603 0.0603
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0484 0.6492
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0015 0.0204
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0115
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.2087 0.8868
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0484 0.6492
Leishmania major DNA polymerase eta, putative 0.0019 0.0105 0.141
Schistosoma mansoni glucose transport protein 0.0105 0.1944 0.5823
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.2087 0.8868
Brugia malayi MH2 domain containing protein 0.012 0.2263 0.3532
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.0373 0.1112
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0139 0.0714
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0062 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.141
Schistosoma mansoni hypothetical protein 0.0041 0.0574 0.172
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0105 0.0541
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0484 0.6492
Toxoplasma gondii sugar transporter ST3 0.0015 0.0015 0.0025
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0105 0.0105
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0044 0.0073
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1814 0.2826
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1846 0.5531
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0607 0.3122
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0015 0.0204
Echinococcus multilocularis GPCR, family 2 0.0016 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0349 0.0525
Giardia lamblia DINP protein human, muc B family 0.0019 0.0105 0.2821
Giardia lamblia Sugar-proton symporter 0.0015 0.0015 0.0408
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0387 0.0387
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0387 0.042
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0603 0.0603
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.2087 0.8868
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0217
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Loa Loa (eye worm) hypothetical protein 0.0043 0.0607 0.093
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0105 0.141
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0105 0.1944 0.1944
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0387 0.199
Onchocerca volvulus Huntingtin homolog 0.0128 0.2429 0.3792
Schistosoma mansoni egf-like domain protein 0.0016 0.0044 0.0131
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Loa Loa (eye worm) hypothetical protein 0.0085 0.1516 0.2358
Giardia lamblia PHD finger protein 15 0.003 0.0349 0.9362
Schistosoma mansoni hypothetical protein 0.0034 0.0431 0.1292
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0486 0.1455
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0396 0.5302
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0015 0.0015
Leishmania major glucose transporter, lmgt1 0.0033 0.0396 0.5302
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0062 0.0068
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0387 0.0641
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.1032
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0396 0.2035
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0486 0.0486
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.2688
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0105 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.0373 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0105 0.0447
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0046
Schistosoma mansoni glucose transport protein 0.0105 0.1944 0.5823
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0396 0.2035
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0344 0.0344
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0387 0.042
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0746 1
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0332
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Brugia malayi jmjC domain containing protein 0.0037 0.0486 0.0739
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0062 0.0321
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0015 0.0078
Schistosoma mansoni hypothetical protein 0.0041 0.0574 0.172
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0486 0.0739
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0045
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0062 0.0835
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0039
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0039
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0746 0.1149
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0105 0.0141
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0038 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0396 0.2035
Brugia malayi Thioredoxin reductase 0.0049 0.0746 0.1149
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0456 0.1365
Echinococcus multilocularis protein patched 0.0043 0.0607 0.0607
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0038 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0105 0.141
Loa Loa (eye worm) hypothetical protein 0.0052 0.0811 0.125
Schistosoma mansoni hypothetical protein 0.0171 0.3338 1
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0085 0.1516 0.1516
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0349 0.0349
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0387 0.5184
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0034 0.0431 0.0654
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Plasmodium falciparum phd finger protein, putative 0.003 0.0349 0.0378
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0015 0.0204
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.0373 0.1919
Schistosoma mansoni glucose transporter 0.0015 0.0015 0.0046
Echinococcus multilocularis protein dispatched 1 0.0049 0.0735 0.0735
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0105 0.0105
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0125 0.0531
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Plasmodium falciparum thioredoxin reductase 0.0049 0.0746 0.0809
Leishmania major protein kinase, putative 0.0032 0.0387 0.5184
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0038 0.0036
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0387 0.042
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0105 0.1944 0.1944
Leishmania major glucose transporter, lmgt2 0.0033 0.0396 0.5302
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0291
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0431 0.0654
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0187
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Loa Loa (eye worm) hypothetical protein 0.0099 0.1814 0.2826
Leishmania major hypothetical protein, conserved 0.0015 0.0015 0.0204
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.2688
Schistosoma mansoni hypothetical protein 0.0105 0.1944 0.5823
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0062 0.0074
Echinococcus granulosus solute carrier family 22 0.0015 0.0015 0.0015
Plasmodium vivax hexose transporter 0.0105 0.1944 0.2107
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1944 1
Mycobacterium ulcerans sugar transporter 0.0015 0.0015 0.0758
Loa Loa (eye worm) hypothetical protein 0.0313 0.6379 1
Echinococcus multilocularis neuropeptide receptor A26 0.0483 1 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0387 0.2129
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0062 0.0068
Entamoeba histolytica protein kinase, putative 0.0032 0.0387 0.2129
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0291
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0387 0.042
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.2087 0.8804
Schistosoma mansoni sugar transporter 0.0015 0.0015 0.0046
Trypanosoma cruzi hexose transporter, putative 0.0018 0.008 0.1073
Toxoplasma gondii protein kinase, putative 0.0297 0.6039 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.017 0.3326 0.3606
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.2087 0.8868
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1814 0.1814
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.2688
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0062 0.0321
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0105 0.0447
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0349 0.0578
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0039 0.0037
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.2263 0.3532
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0486 0.1455
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Schistosoma mansoni protein kinase 0.0032 0.0387 0.1159
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0062 0.0835
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.1323
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0078
Loa Loa (eye worm) hypothetical protein 0.0245 0.4933 0.7728
Trypanosoma brucei trypanothione reductase 0.0049 0.0746 1
Brugia malayi jmjC domain containing protein 0.01 0.1827 0.2846
Plasmodium falciparum thioredoxin reductase 0.0017 0.0062 0.0068
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0038 0.0038
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0044 0.0045
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0039 0.0039
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.0339
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Plasmodium falciparum glutathione reductase 0.0049 0.0746 0.0809
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0039 0.0039
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1827 0.1827
Brugia malayi methionyl-tRNA synthetase 0.0099 0.1816 0.283
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0387 0.042
Echinococcus granulosus peregrin 0.003 0.0349 0.0349
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0484 0.0802
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0115
Entamoeba histolytica hypothetical protein 0.0035 0.0456 0.2508
Giardia lamblia Hexose transporter 0.0015 0.0015 0.0408
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Echinococcus granulosus geminin 0.0171 0.3338 0.3338
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0607 0.093
Onchocerca volvulus Alhambra homolog 0.003 0.0349 0.0525
Brugia malayi PHD-finger family protein 0.003 0.0349 0.0525
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0396 0.5302
Echinococcus granulosus laminin 0.0016 0.0044 0.0044
Trypanosoma brucei glucose transporter 2A 0.0033 0.0396 0.5302
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.0373 0.1117
Schistosoma mansoni DNA polymerase eta 0.0019 0.0105 0.0315
Echinococcus multilocularis General substrate transporter 0.009 0.1628 0.1628
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.4933 0.4933
Echinococcus granulosus expressed conserved protein 0.0093 0.1685 0.1685
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1814 0.1814
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0601
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0039 0.0064
Toxoplasma gondii thioredoxin reductase 0.0049 0.0746 0.1236
Schistosoma mansoni hypothetical protein 0.0016 0.0038 0.0115
Toxoplasma gondii facilitative glucose transporter GT1 0.0105 0.1944 0.3218
Brugia malayi hypothetical protein 0.0313 0.6379 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0105 0.141
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0396 0.2035
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0201
Echinococcus multilocularis solute carrier family 22 0.0015 0.0015 0.0015
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0349 0.0578
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0387 0.0584
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0039 0.0522
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0062 0.0062
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0105 0.5245
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0039 0.0522
Schistosoma mansoni hypothetical protein 0.0041 0.0574 0.172
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0746 0.0746
Schistosoma mansoni patched 1 0.0043 0.0607 0.1818
Trypanosoma brucei glucose transporter, putative 0.0033 0.0396 0.5302
Loa Loa (eye worm) sugar transporter 0.0105 0.1944 0.303
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0062 0.3108
Leishmania major DNA polymerase kappa, putative 0.0019 0.0105 0.141
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.2721 0.2721
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0105 0.141
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.017 0.3326 0.5506
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0062 0.0835
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0062 0.0265
Schistosoma mansoni survival motor neuron protein 0.005 0.0767 0.2298
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0078
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0767 0.1182
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0044 0.0045
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0044 0.0045
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0039 0.0042
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.2721 0.2721
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1814 0.9984
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0062 0.0835
Schistosoma mansoni protein kinase 0.0032 0.0387 0.1159
Schistosoma mansoni hypothetical protein 0.003 0.0349 0.1046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0044 0.0045
Schistosoma mansoni hypothetical protein 0.0035 0.0456 0.1365
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0015 0.0204
Brugia malayi Cam kinase protein 1 0.0032 0.0387 0.0584
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.2353 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0062 0.0835
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0105 0.0105
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0105 0.0315
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0015 0.0078
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.2353 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1827 0.1827
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0085 0.1516 0.1516
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0746 0.0746
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0607 0.0607
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0015 0.0758
Plasmodium vivax glutathione reductase, putative 0.0049 0.0746 0.0809
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0746 0.3171
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0039 0.0522
Loa Loa (eye worm) glutathione reductase 0.0049 0.0746 0.1149

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 4.2 uM Anticoagulant potency in human plasma assessed as concentration required for 1.5 fold extension of prothombin time ChEMBL. 18053714
CL (ADMET) = 13 ml/min.kg Plasma clearance in Sprague-Dawley rat ChEMBL. 18053714
F (ADMET) = 52 % Oral bioavailability in Sprague-Dawley rat ChEMBL. 18053714
Ki (binding) = 0.2 nM Inhibition of factor 10a (unknown origin) ChEMBL. 18053714
Ki (binding) = 0.2 nM Inhibition of factor 10a (unknown origin) ChEMBL. 18053714
Log D = 2.54 Distribution coefficient, log D of the compound ChEMBL. 18053714
PB (ADMET) = 92.1 % Protein binding to human serum albumin ChEMBL. 18053714
PB (ADMET) = 92.1 % Protein binding to human serum albumin ChEMBL. 18053714
pKa = 7.26 Dissociation constant, pKa of the compound ChEMBL. 18053714
t1/2 (ADMET) = 1 hr Half life in Sprague-Dawley rat ChEMBL. 18053714
Vdss (ADMET) = 0.6 L/Kg Volume of distribution at steady state in Sprague-Dawley rat ChEMBL. 18053714

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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