Detailed information for compound 539946

Basic information

Technical information
  • TDR Targets ID: 539946
  • Name: 5-(4-iodophenyl)sulfonyl-1-methyl-4-nitro-imi dazole
  • MW: 393.158 | Formula: C10H8IN3O4S
  • H donors: 0 H acceptors: 5 LogP: 1.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(cc1)S(=O)(=O)c1n(C)cnc1[N+](=O)[O-]
  • InChi: 1S/C10H8IN3O4S/c1-13-6-12-9(14(15)16)10(13)19(17,18)8-4-2-7(11)3-5-8/h2-6H,1H3
  • InChiKey: FPYKZSSYHWAAOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-iodophenyl)sulfonyl-1-methyl-4-nitroimidazole
  • 1-methyl-4-nitro-5-imidazolyl-4-iodophenyl sulfone
  • 131134-90-2
  • 1H-Imidazole, 5-((4-iodophenyl)sulfonyl)-1-methyl-4-nitro-
  • Mniips

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0139 0.0118
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0518 0.0591
Leishmania major DNA polymerase eta, putative 0.0019 0.0172 0.1554
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Brugia malayi glutathione reductase 0.005 0.0826 0.0943
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0506 0.0486
Schistosoma mansoni hypothetical protein 0.0044 0.0701 0.077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0484 0.055
Onchocerca volvulus 0.0015 0.0091 0.0039
Brugia malayi hypothetical protein 0.0015 0.0091 0.0104
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0139 1
Treponema pallidum NADH oxidase 0.0017 0.0139 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.2666 0.3221
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0562 0.6587
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0562 0.6601
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0518 0.0963
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0695 0.3277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0372 0.0351
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0484 0.0552
Schistosoma mansoni hypothetical protein 0.0165 0.3213 0.3902
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0518 0.0963
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0518 0.6023
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.052 0.0591
Onchocerca volvulus 0.0015 0.0091 0.0039
Echinococcus multilocularis solute carrier family 22 0.0015 0.0091 0.0109
Onchocerca volvulus 0.0015 0.0091 0.0039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.2173 0.4694
Echinococcus multilocularis tumor protein p63 0.0341 0.6894 0.8507
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0083 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.2173 0.4694
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0139 0.1158
Echinococcus granulosus GPCR family 2 0.0034 0.0484 0.0594
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0139 0.1122
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0139 0.1122
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0139 0.1122
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0518 0.0637
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0826 0.0795
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0139 0.0052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.1014 0.1249
Leishmania major lysyl-tRNA synthetase, putative 0.0024 0.0277 0.2907
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0083 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1746 0.2074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0518 0.0543
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.052 0.05
Schistosoma mansoni alpha glucosidase 0.0036 0.052 0.0545
Trypanosoma brucei trypanothione reductase 0.005 0.0826 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0963
Echinococcus multilocularis expressed conserved protein 0.0101 0.1878 0.2316
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Brugia malayi Pre-SET motif family protein 0.043 0.876 1
Echinococcus granulosus cpg binding protein 0.003 0.0392 0.0481
Plasmodium vivax calcium-dependent protein kinase, putative 0.0033 0.0464 0.0404
Loa Loa (eye worm) sugar transporter 0.0015 0.0091 0.0101
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.2173 0.8805
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0695 0.8306
Plasmodium falciparum proline--tRNA ligase 0.0038 0.0562 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.052 0.6043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0589
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0963
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0139 0.0792
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Plasmodium vivax CDK-related protein kinase 6, putative 0.0457 0.9333 1
Trypanosoma cruzi hexose transporter 0.0033 0.0473 0.5436
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0139 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus granulosus geminin 0.0165 0.3213 0.3963
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0109
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0518 0.0963
Loa Loa (eye worm) hypothetical protein 0.0062 0.1074 0.1224
Loa Loa (eye worm) hypothetical protein 0.0034 0.0484 0.055
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Plasmodium falciparum protein kinase 7 0.0304 0.6137 0.6542
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.2014 0.2483
Onchocerca volvulus 0.0036 0.0518 0.0469
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.052 0.0593
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0032 0.045 0.0552
Plasmodium falciparum protein kinase 6 0.0457 0.9333 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.2017 0.2301
Brugia malayi beta-lactamase 0.0036 0.0518 0.0591
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0091 0.1544
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0172 0.3152
Loa Loa (eye worm) hypothetical protein 0.0024 0.0277 0.0313
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0473 0.0452
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0518 0.0963
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0083 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0083 0.0062
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0473 0.0452
Echinococcus granulosus dnaJ subfamily B 0.0398 0.8104 1
Onchocerca volvulus 0.0015 0.0091 0.0039
Brugia malayi MH1 domain containing protein 0.0016 0.0105 0.012
Brugia malayi MH2 domain containing protein 0.0016 0.0105 0.012
Echinococcus granulosus dna polymerase kappa 0.0019 0.0172 0.0209
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0484 0.0594
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus multilocularis dna polymerase eta 0.0019 0.0172 0.0209
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Schistosoma mansoni glucose transport protein 0.0108 0.2026 0.2423
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Echinococcus multilocularis protein dispatched 1 0.0052 0.0871 0.1072
Loa Loa (eye worm) hypothetical protein 0.0073 0.1307 0.149
Brugia malayi MH2 domain containing protein 0.0232 0.4633 0.5288
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.052 0.05
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.1074 0.1323
Loa Loa (eye worm) hypothetical protein 0.0013 0.0052 0.0056
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0473 0.5454
Schistosoma mansoni hypothetical protein 0.0165 0.3213 0.3902
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1746 0.1993
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0518 0.604
Schistosoma mansoni hypothetical protein 0.0047 0.0764 0.085
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.05
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.2014 0.2483
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Schistosoma mansoni protein kinase 0.0033 0.0464 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0277 0.5225
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0507 0.5883
Loa Loa (eye worm) hypothetical protein 0.0026 0.0323 0.0366
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0172 0.0183
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Plasmodium falciparum thioredoxin reductase 0.0017 0.0139 0.0052
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.0031
Schistosoma mansoni glucose transport protein 0.0108 0.2026 0.2423
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0764 0.0872
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0083 0.0092
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.4527 1
Brugia malayi major facilitator superfamily protein 0.0015 0.0091 0.0104
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.1074 0.1323
Echinococcus granulosus dna polymerase eta 0.0019 0.0172 0.0209
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.0031
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0172 0.0111
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Brugia malayi MH1 domain containing protein 0.0016 0.0105 0.012
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0139 0.0079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0484 0.0594
Echinococcus multilocularis General substrate transporter 0.0093 0.171 0.2107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.2017 0.2303
Loa Loa (eye worm) hypothetical protein 0.0232 0.4629 0.5283
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.1554
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0518 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0695 0.0675
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0201 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.027 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Mycobacterium leprae Probable lipase LipE 0.0036 0.0518 0.1415
Brugia malayi Sugar transporter family protein 0.0015 0.0091 0.0104
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0038 0.0562 0.6587
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0051 0.0056
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0929 0.1387
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0109
Plasmodium falciparum hexose transporter 0.0108 0.2026 0.2094
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0518 0.1415
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trypanosoma brucei glucose transporter 2A 0.0033 0.0473 0.5454
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1307 0.1492
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0518 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1746 0.2153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.1554
Trypanosoma brucei glycosyl hydrolase-like protein 0.0013 0.0052 0.0041
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Giardia lamblia GTOR 0.0044 0.0695 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0172 0.0151
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Onchocerca volvulus 0.0015 0.0091 0.0039
Brugia malayi lysyl-tRNA synthetase 0.0024 0.0277 0.0316
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.052 0.2384
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.007
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0695 0.8306
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0172 0.0196
Schistosoma mansoni glucose transport protein 0.0108 0.2026 0.2423
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0139 0.249
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0052 0.0031
Brugia malayi Smad1 0.0016 0.0105 0.012
Plasmodium vivax hexose transporter 0.0108 0.2026 0.2094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0324 0.0304
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0484 0.0552
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.052 0.0638
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0506 0.0486
Trichomonas vaginalis esterase, putative 0.0036 0.0518 0.0498
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.1589
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Leishmania major hypothetical protein, conserved 0.0036 0.0518 0.6023
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0518 0.0963
Onchocerca volvulus 0.0047 0.0764 0.0716
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0695 0.0855
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0033 0.0464 0.0569
Schistosoma mansoni smad1 5 8 and 0.0016 0.0105 0.0028
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.2014 0.2299
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0518 0.0498
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.1074 0.1236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0506 0.0486
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0174 0.3413 0.3595
Schistosoma mansoni glucose transporter 0.0015 0.0091 0.001
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0033 0.0464 0.0527
Trypanosoma brucei sugar transporter, putative 0.0015 0.0091 0.0543
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0024 0.0277 0.2936
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0473 0.5436
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0695 0.8313
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0083 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.027 0.025
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0083 0.0402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.001
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0473 0.5454
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0032 0.045 0.0513
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0091 0.0504
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0589
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.052 0.05
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Onchocerca volvulus 0.0015 0.0091 0.0039
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0735 0.0905
Loa Loa (eye worm) beta-lactamase 0.0036 0.0518 0.0589
Leishmania major trypanothione reductase 0.005 0.0826 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.0498
Trypanosoma brucei THT1 - hexose transporter, putative 0.0033 0.0473 0.5454
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0024 0.0277 0.0338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0506 0.0486
Echinococcus multilocularis GPCR, family 2 0.0034 0.0484 0.0594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0271 0.0251
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0052 0.0031
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.3134 0.3865
Loa Loa (eye worm) hypothetical protein 0.005 0.0816 0.0929
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0033 0.0464 0.0404
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Trypanosoma brucei glucosidase, putative 0.0036 0.052 0.606
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Entamoeba histolytica hypothetical protein 0.0024 0.0277 0.1147
Mycobacterium ulcerans sugar transporter 0.0015 0.0091 0.1544
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0518 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0091 0.007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.1074 0.1236
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0319 0.0298
Echinococcus granulosus Niemann Pick C1 protein 0.0153 0.2975 0.367
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0083 0.0402
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0139 0.249
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0091 0.007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0695 0.8306
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0091 0.0109
Plasmodium falciparum calcium-dependent protein kinase 2 0.0033 0.0464 0.0404
Loa Loa (eye worm) transcription factor SMAD2 0.0232 0.4633 0.5287
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0091 0.0104
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0695 0.0855
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.052 0.2384
Onchocerca volvulus 0.0093 0.1717 0.1674
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0033 0.0464 0.0527
Onchocerca volvulus 0.0015 0.0091 0.0039
Plasmodium falciparum glutathione reductase 0.005 0.0826 0.0795
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0105 0.0117
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0963
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0695 0.8306
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0091 0.0109
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1746 0.1991
Schistosoma mansoni survival motor neuron protein 0.0047 0.0764 0.085
Echinococcus multilocularis cpg binding protein 0.003 0.0392 0.0481
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0277 0.0242
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0172 0.1554
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0359 0.0407
Brugia malayi beta-lactamase family protein 0.0036 0.0518 0.0591
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0735 0.0837
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0139 0.0118
Schistosoma mansoni lysyl-tRNA synthetase 0.0024 0.0277 0.0242
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.2441 0.5298
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1746 0.2153
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0473 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0735 0.0716
Trichomonas vaginalis CAMK family protein kinase 0.0033 0.0464 0.0444
Schistosoma mansoni hypothetical protein 0.0044 0.0701 0.077
Toxoplasma gondii facilitative glucose transporter GT1 0.0108 0.2026 0.3201
Schistosoma mansoni hypothetical protein 0.0108 0.2026 0.2423
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0091 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Echinococcus granulosus expressed conserved protein 0.0101 0.1878 0.2316
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0172 0.0111
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0105 0.0127
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0105 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1062 0.1221
Echinococcus multilocularis solute carrier family 22 0.0015 0.0091 0.0109
Schistosoma mansoni smad 0.0016 0.0105 0.0028
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0172 0.0194
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0139 0.0069
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.052 0.05
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0091 0.0504
Onchocerca volvulus 0.0036 0.0518 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0108 0.2026 0.2009
Brugia malayi hypothetical protein 0.0015 0.0091 0.0104
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0139 0.0158
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.0498
Trypanosoma brucei unspecified product 0.0019 0.0172 0.1589
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.052 0.05
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.045 0.0457
Echinococcus multilocularis lysyl tRNA synthetase 0.0024 0.0277 0.0339
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0139 0.1158
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.001
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0091 0.007
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0473 0.5436
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0091 0.0101
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.8104 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1746 0.2074
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0033 0.0464 0.0617
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.1074 0.1236
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.1589
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Mycobacterium ulcerans beta-lactamase 0.0036 0.0518 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0105 0.0127
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0589
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.052 0.0638
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Leishmania major protein kinase, putative 0.0033 0.0464 0.5321
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0032 0.045 0.043
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0139 0.1122
Echinococcus multilocularis geminin 0.0165 0.3213 0.3963
Onchocerca volvulus 0.0015 0.0091 0.0039
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0277 0.0256
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0826 0.094
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1746 0.2074
Schistosoma mansoni cpg binding protein 0.003 0.0392 0.0386
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0105 0.0117
Schistosoma mansoni DNA polymerase eta 0.0019 0.0172 0.0111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.1074 0.1323
Echinococcus granulosus Smad4 0.0016 0.0105 0.0127
Schistosoma mansoni protein kinase 0.0033 0.0464 0.0475
Schistosoma mansoni hypothetical protein 0.0044 0.0701 0.077
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0032 0.045 0.0457
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0172 0.0196
Echinococcus granulosus tumor protein p63 0.0341 0.6894 0.8507
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.4629 0.5711
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0139 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Schistosoma mansoni smad1 5 8 and 0.0016 0.0105 0.0028
Entamoeba histolytica protein kinase, putative 0.0033 0.0464 0.2099
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0109
Giardia lamblia Prolyl-tRNA synthetase 0.0032 0.045 0.5944
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0826 0.1017
Mycobacterium tuberculosis Probable reductase 0.0115 0.2173 0.4694
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0209 0.2071
Schistosoma mansoni serine/threonine protein kinase 0.0033 0.0464 0.0475
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0816 0.0914
Brugia malayi beta-lactamase family protein 0.0036 0.0518 0.0591
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0459 0.0609
Echinococcus granulosus smad 0.0016 0.0105 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0473 0.0452
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0473 0.0452
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0473 0.0452
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Brugia malayi CXXC zinc finger family protein 0.0028 0.0359 0.041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.1554
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.3134 0.3576
Plasmodium falciparum thioredoxin reductase 0.005 0.0826 0.0795
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0042 0.0048
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0105 0.0127
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0484 0.0594
Onchocerca volvulus 0.0015 0.0091 0.0039
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0735 0.0905
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0021 0.0215 0.0194
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.1074 0.1626
Onchocerca volvulus 0.005 0.0816 0.0768
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0052 0.0031
Toxoplasma gondii lysine-tRNA ligase 0.0024 0.0277 0.0308
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0507 0.5883
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0091 0.0109
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.1074 0.1236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0695 0.0793
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0091 0.1544
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0518 0.6023
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0156 0.1345
Loa Loa (eye worm) Smad1 0.0016 0.0105 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0319 0.0298
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0139 0.4765
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0826 0.1657
Brugia malayi Sugar transporter family protein 0.0108 0.2026 0.2313
Plasmodium falciparum calcium-dependent protein kinase 4 0.0033 0.0464 0.0404
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Schistosoma mansoni protein kinase 0.0033 0.0464 0.0475
Plasmodium vivax glutathione reductase, putative 0.005 0.0826 0.0795
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0735 0.0837
Onchocerca volvulus 0.0062 0.1074 0.1028
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.2017 0.2301
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0052 0.0059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0518 0.0589
Onchocerca volvulus 0.0015 0.0091 0.0039
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0695 0.0791
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.052 0.05
Echinococcus multilocularis protein patched 0.0046 0.0735 0.0905
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0038 0.0562 0.0779
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0109 0.2049 0.2451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0083 0.0062
Trichomonas vaginalis set domain proteins, putative 0.0489 1 1
Leishmania major glucose transporter, lmgt3 0.0033 0.0473 0.5436
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0172 0.3152
Schistosoma mansoni alpha-glucosidase 0.0138 0.2666 0.3221
Plasmodium falciparum lysine--tRNA ligase 0.0024 0.0277 0.0201
Loa Loa (eye worm) glutathione reductase 0.005 0.0826 0.094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0695 0.0675
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0826 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.007
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0172 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0271 0.0251
Mycobacterium ulcerans lipase LipD 0.0036 0.0518 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus multilocularis smad 0.0016 0.0105 0.0127
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0139 0.1158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0271 0.0251
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0589
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.052 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0695 0.0675
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.3134 0.3865
Brugia malayi Cam kinase protein 1 0.0033 0.0464 0.0529
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0518 1
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0139 0.0079
Brugia malayi CHE-14 protein 0.0046 0.0735 0.0839
Schistosoma mansoni hypothetical protein 0.0073 0.1307 0.1527
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0033 0.0464 0.0617
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0042 0.0048
Plasmodium falciparum mitogen-activated protein kinase 2 0.0174 0.3413 0.3595
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0172 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0271 0.0251
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0033 0.0464 0.0404
Toxoplasma gondii protein kinase, putative 0.0304 0.6137 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.052 0.6043
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.05
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.4629 0.5711
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0172 0.1554
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0033 0.0464 0.0529
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0589
Echinococcus multilocularis solute carrier family 22 0.0015 0.0091 0.0109
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0172 0.1554
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0473 0.5436
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0083 0.0402
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.0498
Onchocerca volvulus 0.0015 0.0091 0.0039
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.2173 0.4694
Onchocerca volvulus 0.0028 0.0359 0.0309
Giardia lamblia DINP protein human, muc B family 0.0019 0.0172 0.1346
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0139 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Schistosoma mansoni cpg binding protein 0.0028 0.0359 0.0344
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0033 0.0464 0.0569
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0695 0.0763
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.3134 0.3577
Echinococcus multilocularis solute carrier family 22 0.0015 0.0091 0.0109
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0201 0.0249
Giardia lamblia Lysyl-tRNA synthetase 0.0024 0.0277 0.308
Chlamydia trachomatis lysine--tRNA ligase 0.0024 0.0277 1
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.2173 0.4694
Echinococcus granulosus General substrate transporter 0.0093 0.171 0.2107
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0052 0.0031
Onchocerca volvulus 0.0036 0.0518 0.0469
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0105 0.0127
Toxoplasma gondii thioredoxin reductase 0.005 0.0826 0.1216
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0032 0.045 0.111
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0032 0.045 0.2028
Plasmodium vivax lysine--tRNA ligase, putative 0.0024 0.0277 0.0201
Echinococcus granulosus solute carrier family 22 0.0015 0.0091 0.0109
Onchocerca volvulus 0.0015 0.0091 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0324 0.0304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.056 0.054
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0562 0.6587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0083 0.0062
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.052 0.05
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0473 0.0452
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0024 0.0277 0.2907
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0139 0.0108
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.2441 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0139 0.1158
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Loa Loa (eye worm) hypothetical protein 0.0019 0.0172 0.0194
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1746 0.2153
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus granulosus lysyl tRNA synthetase 0.0024 0.0277 0.0339
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.052 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0324 0.0304
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1746 0.2153
Entamoeba histolytica protein kinase, putative 0.0033 0.0464 0.2099
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0392 0.0371
Loa Loa (eye worm) hypothetical protein 0.0056 0.0952 0.1084
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.2441 0.5298
Toxoplasma gondii ABC1 family protein 0.0036 0.0518 0.0707
Loa Loa (eye worm) hypothetical protein 0.0107 0.2014 0.2297
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0172 0.0209
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0091 0.0504
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0083 0.0441
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0091 0.1544
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0091 0.0504
Echinococcus multilocularis calcium dependent protein kinase 0.0031 0.0421 0.0517
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0518 0.0963
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0518 0.0462
Schistosoma mansoni hypothetical protein 0.0398 0.8104 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0518 0.0963
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0139 0.249
Leishmania major hypothetical protein, conserved 0.0015 0.0091 0.0504
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.3134 0.3865
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0172 0.1589
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0139 0.0168
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0735 0.0905
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.2014 1
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0091 0.0104
Brugia malayi hypothetical protein 0.0015 0.0091 0.0104
Onchocerca volvulus 0.0015 0.0091 0.0039
Loa Loa (eye worm) hypothetical protein 0.0032 0.045 0.0511
Plasmodium falciparum calcium-dependent protein kinase 3 0.0033 0.0464 0.0404
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0172 0.1589
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0139 0.1122
Leishmania major glucose transporter/membrane transporter D2, putative 0.0033 0.0473 0.5436
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0695 0.8313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0506 0.0486
Plasmodium falciparum calcium-dependent protein kinase 5 0.0033 0.0464 0.0404
Leishmania major DNA polymerase kappa, putative 0.0019 0.0172 0.1554
Loa Loa (eye worm) sugar transporter 0.0108 0.2026 0.2311
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0091 0.007
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0139 0.1122
Brugia malayi major facilitator superfamily protein 0.0015 0.0091 0.0104
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0826 0.1017
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0507 0.59
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0032 0.045 0.0513
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0172 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.027 0.025
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Plasmodium falciparum calcium-dependent protein kinase 1 0.0033 0.0464 0.0404
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.043 0.876 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0156 0.1389
Echinococcus granulosus calcium dependent protein kinase 0.0031 0.0421 0.0517
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0091 0.0104
Trypanosoma brucei glucose transporter 1E 0.0033 0.0473 0.5454
Leishmania major glucose transporter, lmgt1 0.0033 0.0473 0.5436
Mycobacterium ulcerans hypothetical protein 0.0036 0.0518 1
Schistosoma mansoni Smad4 0.0016 0.0105 0.0028
Schistosoma mansoni hypothetical protein 0.0044 0.0701 0.077
Schistosoma mansoni patched 1 0.0046 0.0735 0.0814
Onchocerca volvulus 0.0015 0.0091 0.0039
Schistosoma mansoni hypothetical protein 0.0034 0.0484 0.05
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.2173 0.4694
Brugia malayi hypothetical protein 0.0232 0.4629 0.5284
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0033 0.0464 0.5341
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0695 0.3277
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0518 0.0498
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0589
Onchocerca volvulus 0.0015 0.0091 0.0039
Onchocerca volvulus 0.0015 0.0091 0.0039
Loa Loa (eye worm) hypothetical protein 0.0033 0.0464 0.0527
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0484 0.0594
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0091 0.001
Echinococcus multilocularis Smad4 0.0016 0.0105 0.0127
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0108 0.2026 0.2498
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0172 0.0209
Trypanosoma brucei glucose transporter, putative 0.0033 0.0473 0.5454
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.2441 0.5298
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0139 0.0168
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.052 0.6043
Schistosoma mansoni cpg binding protein 0.003 0.0392 0.0386
Leishmania major glucose transporter, lmgt2 0.0033 0.0473 0.5436
Brugia malayi Sugar transporter family protein 0.0015 0.0091 0.0104
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0083 0.0441
Echinococcus multilocularis Niemann Pick C1 protein 0.0153 0.2975 0.367
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0459 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0083 0.0062
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Schistosoma mansoni smad1 5 8 and 0.0016 0.0105 0.0028
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0033 0.0464 0.0617
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0038 0.0562 0.6587
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0108 0.2026 0.2498
Loa Loa (eye worm) hypothetical protein 0.0032 0.045 0.0511
Plasmodium falciparum glutathione reductase 0.0017 0.0139 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.2017 0.2303
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Brugia malayi Thioredoxin reductase 0.005 0.0826 0.0943
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0174 0.3413 0.5495
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0091 0.0543
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0032 0.045 0.0552
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0172 0.0183
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.052 0.05
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0083 0.0402
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0024 0.0277 0.5225
Schistosoma mansoni sugar transporter 0.0015 0.0091 0.001
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Onchocerca volvulus Putative transporter 0.0015 0.0091 0.0039
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0033 0.0464 0.0404
Brugia malayi MH2 domain containing protein 0.0016 0.0105 0.012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0139 0.0052
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0091 0.0109
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0172 0.1589
Plasmodium vivax proline--tRNA ligase, putative 0.0038 0.0562 0.051
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0091 0.007
Plasmodium vivax SET domain protein, putative 0.0062 0.1074 0.1064
Loa Loa (eye worm) MH2 domain-containing protein 0.0232 0.4633 0.5287
Brugia malayi Pre-SET motif family protein 0.0062 0.1074 0.1226

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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