Detailed information for compound 546368

Basic information

Technical information
  • TDR Targets ID: 546368
  • Name: [(2R)-2,3-bis(14-decoxytetradeca-10,12-diynoy loxy)propyl] 2-(trimethylammonio)ethyl phosph ate
  • MW: 974.336 | Formula: C56H96NO10P
  • H donors: 0 H acceptors: 4 LogP: 15.34 Rotable bonds: 48
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCOCC#CC#CCCCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCCCC#CC#CCOCCCCCCCCCC)COP(=O)(OCC[N+](C)(C)C)[O-]
  • InChi: 1S/C56H96NO10P/c1-6-8-10-12-14-28-34-40-47-62-49-42-36-30-24-20-16-18-22-26-32-38-44-55(58)64-52-54(53-66-68(60,61)65-51-46-57(3,4)5)67-56(59)45-39-33-27-23-19-17-21-25-31-37-43-50-63-48-41-35-29-15-13-11-9-7-2/h54H,6-23,26-29,32-35,38-41,44-53H2,1-5H3/t54-/m1/s1
  • InChiKey: XQBMMXSSETXKPX-AXAMJWTMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(2R)-2,3-bis(14-decoxy-1-oxotetradeca-10,12-diynoxy)propyl] 2-(trimethylammonio)ethyl phosphate
  • [(2R)-2,3-bis(14-decoxytetradeca-10,12-diynoyloxy)propyl] 2-(trimethylazaniumyl)ethyl phosphate
  • 1,2-bis(15-oxapentacosa-10,12-diynoyl)-sn-phosphocholine
  • [(2R)-2,3-bis(14-decoxytetradeca-10,12-diynoyloxy)propyl] 2-trimethylazaniumylethyl phosphate
  • [(2R)-2,3-bis(14-decoxytetradeca-10,12-diynoyloxy)propyl] 2-trimethylammonioethyl phosphate
  • [(2R)-2,3-bis(14-decoxy-1-oxotetradeca-10,12-diynoxy)propyl] 2-trimethylammonioethyl phosphate
  • 148077-85-4
  • 1,2-Bis(opdyn)-PC
  • 3,5,9,24-Tetraoxa-4-phosphatetetratriaconta-19,21-diyn-1-aminium, 7-((14-(decyloxy)-1-oxo-10,12-tetradecadiynyl)oxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (R)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0186 0.4758
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0118 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Echinococcus multilocularis snurportin 1 0.0338 0.3342 0.3342
Schistosoma mansoni lipoxygenase 0.0059 0.0502 0.1031
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0071 0.0623 0.1045
Echinococcus multilocularis zinc finger protein 0.0446 0.4442 0.4442
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0042 0.0333 0.0333
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0488 0.4869 0.4869
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.03 0.0376
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Toxoplasma gondii ABC1 family protein 0.0039 0.03 0.1638
Mycobacterium ulcerans hypothetical protein 0.0039 0.03 0.0376
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0119 0.0119
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0071 0.0623 0.5008
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0136
Echinococcus granulosus RUN 0.0021 0.0119 0.0119
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.03 0.0616
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0252 0.0252
Treponema pallidum alginate O-acetylation protein (algI) 0.0042 0.0333 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0333 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0488 0.4869 0.4869
Echinococcus granulosus dna polymerase kappa 0.0021 0.0118 0.0118
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0196 0.5129
Schistosoma mansoni DNA polymerase eta 0.0021 0.0118 0.0242
Echinococcus granulosus GPCR family 2 0.0016 0.0066 0.0066
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0118 0.2339
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.0502 0.0502
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.03 0.03
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0143 0.0474
Mycobacterium ulcerans beta-lactamase 0.0039 0.03 0.0376
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0333
Plasmodium vivax hypothetical protein, conserved 0.0039 0.03 0.359
Loa Loa (eye worm) hypothetical protein 0.0049 0.0408 0.0408
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0143 0.3219
Onchocerca volvulus 0.0042 0.0333 0.0881
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0333 0.0333
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0333 0.0333
Onchocerca volvulus 0.0061 0.0531 0.169
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0333 0.0333
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0496 0.4952 1
Brugia malayi beta-lactamase family protein 0.0039 0.03 0.03
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0066 0.0066
Leishmania major glycerol uptake protein, putative 0.0042 0.0333 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.03 0.0376
Onchocerca volvulus 0.0039 0.03 0.0743
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0071 0.0623 0.1045
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0333 0.0583
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0143 0.1149
Schistosoma mansoni cpg binding protein 0.0065 0.0566 0.1163
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0496 0.4952 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0252 0.0517
Entamoeba histolytica hypothetical protein 0.0026 0.0167 0.2266
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0919 0.9255 0.9255
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.03 0.0376
Brugia malayi MBOAT family protein 0.0488 0.4869 0.4869
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0098 0.0902 0.0902
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0042 0.0333 0.0333
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0333 0.0333
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0118 0.0242
Leishmania major importin beta-1 subunit, putative 0.0026 0.0167 0.2266
Echinococcus granulosus dnaJ subfamily B 0.0448 0.446 0.446
Brugia malayi Hhat protein 0.0042 0.0333 0.0333
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0042 0.0333 0.0333
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1467 0.1467
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0071 0.0623 0.0917
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0136
Mycobacterium leprae conserved hypothetical protein 0.0039 0.03 0.0239
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0143 0.1149
Echinococcus granulosus zinc finger protein 0.0446 0.4442 0.4442
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0071 0.0623 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0034 0.0252 0.0252
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.03 0.03
Plasmodium vivax SET domain protein, putative 0.0034 0.0252 0.2638
Schistosoma mansoni hypothetical protein 0.0021 0.0119 0.0244
Mycobacterium leprae Probable lipase LipE 0.0039 0.03 0.0239
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0333 0.0685
Onchocerca volvulus 0.0098 0.0902 0.3213
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0042 0.0333 0.1989
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0118 0.0144
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0252 0.0252
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0247 0.2423 0.4769
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.03 0.0376
Schistosoma mansoni sterol O-acyltransferase 1 0.0042 0.0333 0.0685
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0136
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0252 0.0517
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0073 0.0073
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0071 0.0623 0.1045
Brugia malayi hypothetical protein 0.0021 0.0119 0.0119
Leishmania major glycerol uptake protein, putative 0.0042 0.0333 1
Echinococcus granulosus snurportin 1 0.0338 0.3342 0.3342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0119
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0196 0.154
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0186 0.0452
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0118 0.0118
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0042 0.0333 0.0685
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.03 0.0515
Trichomonas vaginalis ran, putative 0.0023 0.0143 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1467 0.3013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0338 0.3342 0.3342
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0228 0.6238
Echinococcus multilocularis cpg binding protein 0.0065 0.0566 0.0566
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0748 0.751 0.751
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0333 1
Mycobacterium ulcerans lipase LipD 0.0039 0.03 0.0376
Brugia malayi hypothetical protein 0.0029 0.0196 0.0196
Brugia malayi Pre-SET motif family protein 0.0034 0.0252 0.0252
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.03 0.03
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0071 0.0623 0.1045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0066 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.1289 0.1289
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0042 0.0333 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.03 0.0515
Echinococcus multilocularis ornithine aminotransferase 0.0071 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.03
Brugia malayi MBOAT family protein 0.0042 0.0333 0.0333
Schistosoma mansoni rab6-interacting 0.0021 0.0119 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1467 0.3013
Echinococcus multilocularis dnaJ subfamily B 0.0448 0.446 0.446
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0333 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.03 0.0376
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0412 0.0412
Echinococcus multilocularis tumor protein p63 0.0338 0.3339 0.3339
Mycobacterium tuberculosis Probable aminotransferase 0.0496 0.4952 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0252 0.0252
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.03
Onchocerca volvulus 0.0039 0.03 0.0743
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0071 0.0623 0.128
Schistosoma mansoni ran 0.0023 0.0143 0.0293
Brugia malayi MBOAT family protein 0.0042 0.0333 0.0333
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0186 0.3158
Schistosoma mansoni hypothetical protein 0.0057 0.0484 0.0993
Schistosoma mansoni hypothetical protein 0.0338 0.3342 0.6862
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1244 0.2554
Brugia malayi RNA, U transporter 1 0.009 0.0821 0.0821
Schistosoma mansoni loxhd1 0.0021 0.0119 0.0244
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0066 0.0066
Trypanosoma brucei unspecified product 0.0021 0.0118 0.2339
Plasmodium falciparum ornithine aminotransferase 0.0071 0.0623 1
Toxoplasma gondii hypothetical protein 0.0042 0.0333 0.1989
Mycobacterium ulcerans hypothetical protein 0.0496 0.4952 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0118 0.0144
Brugia malayi hypothetical protein 0.0279 0.2739 0.2739
Echinococcus granulosus L aminoadipate semialdehyde 0.0098 0.0902 0.0902
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0071 0.0623 0.1045
Schistosoma mansoni hypothetical protein 0.0448 0.446 0.9159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0252 0.0517
Mycobacterium tuberculosis Conserved protein 0.0039 0.03 0.0376
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0228 0.0886
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0073 0.015
Leishmania major GTP-binding protein, putative 0.0023 0.0143 0.1149
Echinococcus multilocularis survival motor neuron protein 1 0.0279 0.2739 0.2739
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0118 0.0118
Loa Loa (eye worm) hhat protein 0.0042 0.0333 0.0333
Brugia malayi beta-lactamase 0.0039 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0992 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0118 0.2339
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0229 0.2237 0.2237
Brugia malayi Doublecortin family protein 0.0021 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0252 0.1138
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0119 0.0119
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0109 0.0109
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0111 0.0111
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0071 0.0623 0.0917
Leishmania major hypothetical protein, conserved 0.0029 0.0196 0.3642
Brugia malayi follicle stimulating hormone receptor 0.0748 0.751 0.751
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0042 0.0333 0.0333
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0016 0.0066 0.0066
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0042 0.0333 0.0685
Brugia malayi hypothetical protein 0.0021 0.0119 0.0119
Entamoeba histolytica vacuolar protein sorting 26 0.0042 0.0333 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0496 0.4952 1
Leishmania major hypothetical protein, conserved 0.0039 0.03 0.8438
Schistosoma mansoni cpg binding protein 0.0065 0.0566 0.1163
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0226 0.0226
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0408 0.0839
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0333 1
Entamoeba histolytica hypothetical protein 0.0028 0.0186 0.3158
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0118 0.0118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0073 0.0073
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0143 0.0143
Loa Loa (eye worm) hhat protein 0.0042 0.0333 0.0333
Trypanosoma cruzi GUP1, putative 0.0042 0.0333 1
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0042 0.0333 0.0333
Echinococcus granulosus cpg binding protein 0.0065 0.0566 0.0566
Schistosoma mansoni polycystin 1-related 0.0021 0.0119 0.0244
Loa Loa (eye worm) CXXC zinc finger family protein 0.0061 0.0531 0.0531
Echinococcus multilocularis muscleblind protein 1 0.0992 1 1
Brugia malayi hypothetical protein 0.0018 0.0093 0.0093
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0071 0.0623 0.1045
Echinococcus multilocularis ornithine aminotransferase 0.0071 0.0623 0.0623
Schistosoma mansoni cpg binding protein 0.0061 0.0531 0.109
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0333 0.0685
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0042 0.0333 0.0333
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0484 0.0484
Brugia malayi CXXC zinc finger family protein 0.0061 0.0531 0.0531
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Echinococcus multilocularis RUN 0.0021 0.0119 0.0119
Plasmodium vivax ornithine aminotransferase, putative 0.0071 0.0623 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.03 0.0515
Trypanosoma cruzi glycerol uptake protein, putative 0.0042 0.0333 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.1467 0.1467
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0071 0.0623 0.1045
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.03
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0252 0.0517
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0119 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Loa Loa (eye worm) MBOAT family protein 0.0488 0.4869 0.4869
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0196 0.154
Plasmodium falciparum importin beta, putative 0.0032 0.0228 0.2159
Echinococcus granulosus survival motor neuron protein 1 0.0279 0.2739 0.2739
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0186 0.0141
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0167 0.2266
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0333 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0098 0.0902 0.1852
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0118 0.2339
Brugia malayi MH2 domain containing protein 0.0136 0.1289 0.1289
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0118 0.0118
Loa Loa (eye worm) histone methyltransferase 0.002 0.0111 0.0111
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0119 0.0119
Trypanosoma brucei glycerol uptake protein, putative 0.0042 0.0333 1
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0071 0.0623 0.1045
Loa Loa (eye worm) hypothetical protein 0.0279 0.2739 0.2739
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0143 0.0143
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0098 0.0902 0.0902
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.1289 0.1289
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.03 0.8438
Onchocerca volvulus 0.0057 0.0484 0.1497
Trichomonas vaginalis esterase, putative 0.0039 0.03 0.0515
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0333 1
Echinococcus multilocularis sterol O acyltransferase 1 0.0042 0.0333 0.0333
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0118 0.2339
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0186 0.1333
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0228 0.6238
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.0502 0.0502
Plasmodium vivax importin-beta 2, putative 0.0032 0.0228 0.2159
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0119 0.0119
Echinococcus granulosus importin subunit beta 1 0.0032 0.0228 0.0228
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0333 0.0333
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0333 0.0583
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.03 0.03
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.03 0.0376
Loa Loa (eye worm) beta-lactamase 0.0039 0.03 0.03
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0412 0.0412
Echinococcus granulosus dna polymerase eta 0.0021 0.0118 0.0118
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0042 0.0333 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0186 0.0141
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0196 0.3642
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0333
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0042 0.0333 0.4258
Trichomonas vaginalis transmembrane protein nessy, putative 0.0042 0.0333 0.0583
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0167 0.0243
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0186 0.0141
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.03
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.1467 0.1467
Mycobacterium ulcerans L-lysine aminotransferase 0.0071 0.0623 0.1045
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0066 0.0066
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.03 0.0376
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0073 0.0073
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0042 0.0333 0.4258
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Brugia malayi MBOAT family protein 0.0042 0.0333 0.0333
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1467 0.1467
Loa Loa (eye worm) hypothetical protein 0.0021 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0333 0.0583
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0143 0.0143
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0143 1
Echinococcus granulosus tumor protein p63 0.0338 0.3339 0.3339
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0066 0.0066
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0071 0.0623 1
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0042 0.0333 0.0333
Schistosoma mansoni zinc finger protein 0.0488 0.4869 1
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0042 0.0333 0.0333
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.03 0.0515
Schistosoma mansoni hypothetical protein 0.0016 0.0066 0.0136
Loa Loa (eye worm) MBOAT family protein 0.0042 0.0333 0.0333
Echinococcus multilocularis L aminoadipate semialdehyde 0.0098 0.0902 0.0902
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0071 0.0623 0.0623
Mycobacterium tuberculosis Conserved protein 0.0039 0.03 0.0376
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0036 0.0036
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0228 0.0228
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0042 0.0333 0.0333
Echinococcus multilocularis dna polymerase eta 0.0021 0.0118 0.0118
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0186 0.1333
Mycobacterium ulcerans acetylornithine aminotransferase 0.0071 0.0623 0.1045
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.1467 0.1467
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.03 0.0616
Schistosoma mansoni ran 0.0023 0.0143 0.0293
Schistosoma mansoni survival motor neuron protein 0.0057 0.0484 0.0993
Leishmania major glycerol uptake protein, putative 0.0042 0.0333 1
Schistosoma mansoni lipoxygenase 0.0021 0.0119 0.0244
Brugia malayi Importin beta-1 subunit 0.0032 0.0228 0.0228
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0119 0.0119
Echinococcus granulosus muscleblind protein 0.0992 1 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0071 0.0623 0.0917
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0186 0.0452
Echinococcus multilocularis Aminotransferase class III 0.0071 0.0623 0.0623
Onchocerca volvulus 0.0039 0.03 0.0743
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0143 0.0143
Schistosoma mansoni importin beta-1 0.0032 0.0228 0.0467
Onchocerca volvulus 0.0261 0.2557 1
Onchocerca volvulus 0.0034 0.0252 0.0546
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.03
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0042 0.0333 0.1989
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0143 0.0474
Loa Loa (eye worm) hypothetical protein 0.0032 0.0228 0.0228
Brugia malayi diacylglycerol acyltransferase 0.0042 0.0333 0.0333
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0042 0.0333 0.0685
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Trichomonas vaginalis porcupine, putative 0.0042 0.0333 0.0583
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0042 0.0333 0.0333
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0042 0.0333 0.0685
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.03 0.0376
Leishmania major glycerol uptake protein, putative 0.0042 0.0333 1
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0496 0.4952 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0167 0.0243
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0167 0.0243
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.03 0.0376
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0042 0.0333 0.0685
Brugia malayi beta-lactamase family protein 0.0039 0.03 0.03
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0066 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0118 0.2339
Entamoeba histolytica Ran family GTPase 0.0023 0.0143 0.1149
Echinococcus granulosus o acyltransferase membrane bound domain 0.0042 0.0333 0.0333
Trypanosoma cruzi GUP1, putative 0.0042 0.0333 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0412 0.0412
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.1467 0.3013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0196 0.0196
Trichomonas vaginalis set domain proteins, putative 0.0261 0.2557 0.5116
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0196 0.154
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0196 0.3642
Leishmania major glycerol uptake protein, putative 0.0042 0.0333 1
Schistosoma mansoni rab6-interacting 0.0021 0.0119 0.0244
Echinococcus multilocularis GPCR, family 2 0.0016 0.0066 0.0066
Echinococcus multilocularis muscleblind protein 0.0992 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0119 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0196 0.056
Schistosoma mansoni hypothetical protein 0.0013 0.0036 0.0074
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1102 1
Schistosoma mansoni hypothetical protein 0.0034 0.0252 0.0518
Onchocerca volvulus 0.0049 0.0408 0.1188
Loa Loa (eye worm) hypothetical protein 0.0992 1 1
Brugia malayi MBOAT family protein 0.0042 0.0333 0.0333
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0042 0.0333 0.0333
Echinococcus granulosus ornithine aminotransferase 0.0071 0.0623 0.0623
Loa Loa (eye worm) hypothetical protein 0.0039 0.03 0.03
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.03 0.0376
Echinococcus granulosus sterol O acyltransferase 1 0.0042 0.0333 0.0333
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0118 0.0118
Leishmania major hypothetical protein, conserved 0.0042 0.0333 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0412 0.0412
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0008 0.0016
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0066 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.03 0.0515
Echinococcus granulosus Aminotransferase class III 0.0071 0.0623 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.03 0.8438
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.03 0.8803
Entamoeba histolytica hypothetical protein 0.0042 0.0333 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.1467 0.1467
Brugia malayi Pre-SET motif family protein 0.0229 0.2237 0.2237

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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