Detailed information for compound 555289

Basic information

Technical information
  • TDR Targets ID: 555289
  • Name: dibutyl phenyl phosphate
  • MW: 286.304 | Formula: C14H23O4P
  • H donors: 0 H acceptors: 1 LogP: 3.84 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOP(=O)(Oc1ccccc1)OCCCC
  • InChi: 1S/C14H23O4P/c1-3-5-12-16-19(15,17-13-6-4-2)18-14-10-8-7-9-11-14/h7-11H,3-6,12-13H2,1-2H3
  • InChiKey: YICSVBJRVMLQNS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • phosphoric acid dibutyl phenyl ester
  • dibutyl phenylphosphate
  • 2528-36-1
  • Di(n-butyl) phenyl phosphate
  • EINECS 219-772-7
  • HSDB 2604
  • Phosphoric acid, dibutyl phenyl ester
  • 4-06-00-00710 (Beilstein Handbook Reference)
  • BRN 2140519
  • Butyl phenyl phosphate ((BuO)2(PhO)PO)
  • CCRIS 4604

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0123 0.4141
Brugia malayi Bromodomain containing protein 0.0037 0.0272 0.0804
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0278 0.3384 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0049 0.0076
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0224 0.2691 0.4178
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0224 0.2691 0.4178
Trypanosoma brucei unspecified product 0.0019 0.0038 0.128
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0296 1
Brugia malayi ADAM-TS Spacer 1 family protein 0.0071 0.0714 0.2112
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0113 0.3801
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0123 0.3281
Loa Loa (eye worm) angiogenesis inhibito 0.0026 0.0125 0.0368
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0189 0.639
Giardia lamblia PHD finger protein 15 0.0031 0.0189 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0123 0.4141
Loa Loa (eye worm) hypothetical protein 0.0071 0.0714 0.2111
Echinococcus granulosus adam 0.0161 0.1876 0.2913
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0123 0.3281
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0296 0.0459
Echinococcus granulosus dna polymerase kappa 0.0019 0.0038 0.0059
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0296 1
Echinococcus granulosus zinc finger protein 0.0019 0.0039 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0117
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0076 0.0075
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.128
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0199 0.6709
Brugia malayi isocitrate dehydrogenase 0.0016 0 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0113 0.3801
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0113
Brugia malayi beta-lactamase family protein 0.0039 0.0296 0.0875
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0243 0.0376
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.061 0.1801
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0296 0.087
Onchocerca volvulus 0.0031 0.0199 0.0264
Trichomonas vaginalis esterase, putative 0.0039 0.0296 0.087
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0038 0.128
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0123 0.3281
Schistosoma mansoni bromodomain containing protein 0.0061 0.0583 0.0905
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0296 0.0459
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0095 0.1016 0.1016
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.004 0.1336
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0123 0.3281
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0411 0.0411
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0026 0.0087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0296 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0049 0.1654
Mycobacterium ulcerans lipase LipD 0.0039 0.0296 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0296 0.087
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0117
Mycobacterium tuberculosis Conserved protein 0.0039 0.0296 0.0987
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0049 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0426 0.126
Schistosoma mansoni ap endonuclease 0.002 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0048 0.0411 0.1215
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0226 0.0669
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0296 0.0987
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0296 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0049 0.0146
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0123 0.406
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0539 0.0836
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0123 0.0408
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0296 0.0987
Onchocerca volvulus 0.0039 0.0296 0.0602
Echinococcus granulosus peregrin 0.0033 0.0219 0.0339
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0038 0.0059
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.128
Brugia malayi Pre-SET motif family protein 0.0031 0.0199 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus multilocularis geminin 0.0515 0.6442 0.6441
Brugia malayi Bromodomain containing protein 0.0033 0.0219 0.0647
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.128
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0076 0.0117
Brugia malayi Pre-SET motif family protein 0.0218 0.2612 0.772
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0049 0.2588
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0059
Schistosoma mansoni jumonji domain containing protein 0.008 0.0822 0.1275
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2612 0.7719
Loa Loa (eye worm) hypothetical protein 0.0052 0.0471 0.1392
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0189 0.639
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0123 0.3281
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0411 0.0638
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0254 0.075
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0123 0.4141
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0076 0.0117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0296 0.0459
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0123 0.3281
Brugia malayi Bromodomain containing protein 0.0072 0.073 0.2156
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0123 0.0363
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0049 0.0429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0296 0.0459
Echinococcus multilocularis dna polymerase eta 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0039 0.0302 0.0893
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0247 0.0382
Mycobacterium ulcerans beta-lactamase 0.0039 0.0296 1
Brugia malayi angiogenesis inhibito 0.0071 0.0714 0.2112
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0296 0.0987
Onchocerca volvulus Alhambra homolog 0.0031 0.0189 0.0231
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0007 0.0011
Brugia malayi Disintegrin family protein 0.0123 0.1381 0.4083
Leishmania major hypothetical protein, conserved 0.0025 0.0113 0.3801
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0611 0.0948
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.004 0.209
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0199 0.0198
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0426 0.1259
Loa Loa (eye worm) hypothetical protein 0.0037 0.0273 0.0806
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0123 0.406
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0296 0.0875
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0411 0.0638
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0038 0.0126
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0627
Leishmania major DNA polymerase eta, putative 0.0019 0.0038 0.128
Plasmodium falciparum phd finger protein, putative 0.0031 0.0189 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0368
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0559
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0113 0.5947
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0026 0.0087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.128
Schistosoma mansoni transient receptor potential channel 0.0063 0.0611 0.0948
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0296 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0123 0.3281
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0362
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0199 0.0308
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0278 0.3384 1
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0611 0.0948
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.128
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0296 0.0987
Echinococcus multilocularis disintegrin and metalloproteinase 0.0123 0.1381 0.1381
Brugia malayi hypothetical protein 0.0161 0.1876 0.5546
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0296 0.087
Onchocerca volvulus 0.0249 0.3001 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.004 0.0064
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0296 0.0874
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0362
Brugia malayi Isocitrate dehydrogenase 0.0016 0 0.0001
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.3384 0.5252
Mycobacterium tuberculosis Conserved protein 0.0039 0.0296 0.0987
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0189 0.0293
Schistosoma mansoni transient receptor potential channel 0.0096 0.1029 0.1597
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0296 0.0296
Echinococcus granulosus dna polymerase eta 0.0019 0.0038 0.0059
Echinococcus multilocularis transient receptor potential gamma protein 0.0096 0.1029 0.1028
Brugia malayi jmjC domain containing protein 0.0039 0.0296 0.0875
Mycobacterium tuberculosis Conserved protein 0.0039 0.0296 0.0987
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0189 0.0559
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0038 0.0112
Leishmania major hypothetical protein, conserved 0.0039 0.0296 1
Loa Loa (eye worm) metalloprotease 0.0026 0.0125 0.0368
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.3384 0.5252
Onchocerca volvulus 0.0039 0.0296 0.0602
Echinococcus multilocularis peregrin 0.0033 0.0219 0.0218
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0049 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus multilocularis adam 0.0161 0.1876 0.1876
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0049 0.5
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0189 0.639
Loa Loa (eye worm) beta-lactamase 0.0039 0.0296 0.0874
Schistosoma mansoni hypothetical protein 0.0033 0.0226 0.0351
Echinococcus multilocularis zinc finger protein 0.0019 0.0039 0.0038
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0344 0.0344
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0038 0.0126
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0038 0.0059
Schistosoma mansoni zinc finger protein 0.0019 0.0039 0.006
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0296 1
Brugia malayi PHD-finger family protein 0.0031 0.0189 0.056
Brugia malayi beta-lactamase 0.0039 0.0296 0.0875
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0026 0.0087
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0123 0.0408
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0038 0.0038
Schistosoma mansoni ap endonuclease 0.002 0.0049 0.0076
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0049 0.0049
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0123 0.406
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.004 0.0132
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0332
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0296 0.0459
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0026 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0117
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0874
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0278 0.3384 0.5252
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.2998 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0199 0.6709
Schistosoma mansoni hypothetical protein 0.0515 0.6442 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.3384 0.5252
Loa Loa (eye worm) disintegrin family protein 0.0062 0.0589 0.1739
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus granulosus geminin 0.0515 0.6442 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0113 0.3801
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.004 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0226 0.0668
Schistosoma mansoni dihydroceramide desaturase 0.0123 0.1381 0.2144
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.1087 0.1087
Brugia malayi Reprolysin 0.0163 0.1899 0.5612
Schistosoma mansoni hypothetical protein 0.0515 0.6442 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.1016 0.3003
Brugia malayi jmjC domain containing protein 0.01 0.1087 0.3213
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0988 0.1533
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.3384 0.3383
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0296 0.087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0049 0.1654
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0874
Brugia malayi metalloprotease 0.0026 0.0125 0.0369
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0049 0.5
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0189 0.0189
Echinococcus granulosus disintegrin and metalloproteinase 0.0123 0.1381 0.2144
Mycobacterium ulcerans hypothetical protein 0.0039 0.0296 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0117
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.1087 0.1687
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0049 0.1654
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0038 0.128
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0296 0.0987
Echinococcus granulosus adam 17 protease 0.0061 0.0587 0.0911
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0611 0.0611
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0611 0.0611
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0278 0.3384 0.3383
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0049 0.0037
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0049 0.1654
Loa Loa (eye worm) hypothetical protein 0.0036 0.0254 0.0749
Loa Loa (eye worm) hypothetical protein 0.0019 0.004 0.0117
Schistosoma mansoni transient receptor potential channel 0.0063 0.0611 0.0948
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0016 0.0007 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0096 0.1029 0.304
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0113 0.3801
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0254 0.0393
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0224 0.2691 0.4178
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0095 0.1016 0.1577
Loa Loa (eye worm) hypothetical protein 0.006 0.057 0.1683
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0224 0.2691 0.2691
Brugia malayi PHD-finger family protein 0.0024 0.0105 0.0311
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0247 0.0382
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0988 0.0987
Schistosoma mansoni DNA polymerase eta 0.0019 0.0038 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0199 0.0308
Brugia malayi beta-lactamase family protein 0.0039 0.0296 0.0875
Echinococcus granulosus methyl CpG binding domain protein 2 0.0016 0.0007 0.0011
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0344 0.0533
Schistosoma mansoni hypothetical protein 0.0035 0.0247 0.0382
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0874
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Echinococcus granulosus transient receptor potential gamma protein 0.0096 0.1029 0.1597
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0038 0.0113
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0049 0.0163
Loa Loa (eye worm) hypothetical protein 0.0116 0.1287 0.3803
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0296 0.0987
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0272 0.0272
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0038 0.128
Loa Loa (eye worm) hypothetical protein 0.0068 0.0676 0.1998
Loa Loa (eye worm) hypothetical protein 0.0049 0.0426 0.1259
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0049 0.0732
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0123 0.0363
Loa Loa (eye worm) reprolysin 0.0224 0.2691 0.7954
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0278 0.3384 0.5252
Brugia malayi hypothetical protein 0.0025 0.0113 0.0333
Toxoplasma gondii exonuclease III APE 0.002 0.0049 0.1654
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0052 0.0152
Loa Loa (eye worm) hypothetical protein 0.0071 0.0714 0.2111
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0189 0.0293
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0038 0.0112
Trichomonas vaginalis set domain proteins, putative 0.0249 0.3001 1
Mycobacterium leprae Probable lipase LipE 0.0039 0.0296 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.0362
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0426 0.126
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0296 0.0987
Leishmania major DNA polymerase kappa, putative 0.0019 0.0038 0.128
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0026 0.0125 0.0193
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0254 0.0253
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0874
Schistosoma mansoni transient receptor potential channel 4 0.0096 0.1029 0.1597
Schistosoma mansoni methyl-cpg binding protein mbd 0.0016 0.0007 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0411 0.0638
Entamoeba histolytica hypothetical protein 0.0035 0.0247 1
Brugia malayi hypothetical protein 0.0035 0.0247 0.0729
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0123 0.0363
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0184 0.0285
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0049 0.0531
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0038 0.128
Loa Loa (eye worm) hypothetical protein 0.0041 0.0326 0.0963
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0296 0.0459
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0038 0.128
Onchocerca volvulus 0.0039 0.0296 0.0602
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0113 0.3801
Toxoplasma gondii ABC1 family protein 0.0039 0.0296 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0049 0.1654
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0874
Loa Loa (eye worm) hypothetical protein 0.0039 0.0296 0.0874
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0247 0.0246
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0243 0.0242
Brugia malayi ADAMTS-like protease 0.0071 0.0714 0.2112
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0296 0.087
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0113 0.5947
Loa Loa (eye worm) hypothetical protein 0.0046 0.0384 0.1135
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0161 0.1876 0.2913
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0123 0.3281
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0296 0.0874
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0015 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0296 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.