Detailed information for compound 557007

Basic information

Technical information
  • TDR Targets ID: 557007
  • Name: (+)-Allelrethonyl (+)-cis,trans-chrysanthemat e
  • MW: 302.408 | Formula: C19H26O3
  • H donors: 0 H acceptors: 2 LogP: 3.68 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCC1=C(C)C(CC1=O)OC(=O)C1C(C1(C)C)C=C(C)C
  • InChi: 1S/C19H26O3/c1-7-8-13-12(4)16(10-15(13)20)22-18(21)17-14(9-11(2)3)19(17,5)6/h7,9,14,16-17H,1,8,10H2,2-6H3
  • InChiKey: ZCVAOQKBXKSDMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (+)-Allethronyl (+)-trans-chrysanthemumate
  • (+)-trans-Bioallethrin
  • (+)-trans-Chrysanthemumic acid ester of (.+-.)-allethrolone
  • (+)-trans-Chrysanthemumic acid ester of (+-)-allethrolone
  • (+-)-Allerethonyl (+-)-cis,trans-chrysanthemate
  • (.+-.)-Allelrethonyl (.+-.)-cis,trans-chrysanthemate
  • (2-methyl-4-oxo-3-prop-2-enyl-cyclopent-2-en-1-yl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
  • (2-methyl-4-oxo-3-prop-2-enylcyclopent-2-en-1-yl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
  • (2-methyl-4-oxo-3-prop-2-enyl-1-cyclopent-2-enyl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
  • (3-allyl-2-methyl-4-oxo-cyclopent-2-en-1-yl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate
  • (3-allyl-2-methyl-4-oxo-1-cyclopent-2-enyl) 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate
  • (RS)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl (+-)-cis,trans-chrysanthemate
  • (RS)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl (1R,3R)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate
  • (S)-3-Allyl-3-methyl-4-oxocyclopent-2-enyl (+)-trans-chrysanthemate
  • 137-98-4
  • 18793-35-6
  • 18877-88-8
  • 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylic acid (3-allyl-2-methyl-4-oxo-1-cyclopent-2-enyl) ester
  • 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylic acid (3-allyl-4-keto-2-methyl-cyclopent-2-en-1-yl) ester
  • 2,2-dimethyl-3-(2-methylprop-1-enyl)-1-cyclopropanecarboxylic acid (3-allyl-2-methyl-4-oxo-1-cyclopent-2-enyl) ester
  • 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylic acid (3-allyl-4-keto-2-methyl-1-cyclopent-2-enyl) ester
  • 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester
  • 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid, ester with 2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one
  • 2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylic acid 2-methyl-4-oxo-3-(2-propenyl)-2- cyclopenten-1-yl ester
  • 2-Allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one ester of 2,2-dimethyl-3-(2-methyl propenyl) cyclopropane carboxylic acid
  • 2-Allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one ester of chrysanthemummono-carboxylic acid
  • 2-Cyclopenten-1-one, 2-allyl-4-hydroxy-3-methyl-, 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylate
  • 2-methyl-4-oxo-3-(prop-2-en-1-yl)cyclopent-2-en-1-yl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
  • 2-Methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecar
  • 2-Methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl 2,2-dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarboxylate
  • 20301-61-5
  • 207562-36-5
  • 22431-63-6
  • 22467-86-3
  • 22556-34-9
  • 23453-08-9
  • 24313-23-3
  • 25406-22-8
  • 25406-24-0
  • 25406-25-1
  • 28057-48-9
  • 28434-00-6
  • 28991-27-7
  • 3-allyl-2-methyl-4-oxocyclopent-2-en-1-yl 2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropanecarboxylate
  • 3-Allyl-2-methyl-4-oxo-2-cyclopenten-1-yl chrysanthemate
  • 3-Allyl-2-methyl-4-oxocyclopent-2-en-1-yl (1R-(1alpha(S*),3beta))-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarboxylate
  • 3-Allyl-4-keto-2-methylcyclopentenyl chrysanthemum monocarboxylate
  • 3-Allyl-4-keto-2-methylcyclopentenyl chrysanthemummonocarboxylate
  • 3-Allyl-4-methyl-2-oxo-3-cyclopenten-1-yl ester of 2,2-dimethyl-3-(2-methylpropenyl)cyclopropanecarboxylic acid
  • 34624-48-1
  • 3972-20-1
  • 4-09-00-00174 (Beilstein Handbook Reference)
  • 42534-61-2
  • 584-79-2
  • 6385-67-7
  • 6385-68-8
  • 71119-51-2
  • 71211-88-6
  • 8018-12-0
  • 84030-86-4
  • AI 3-29024
  • AI3-17510
  • Allethrin
  • Allethrin I
  • Allethrin [BSI:ISO]
  • Allethrin coil
  • Allethrine
  • Allethrine [ISO-French]
  • Allethrolone ester of chrysanthemummonocarboxylic acid
  • Allyl cinerin
  • Allyl cinerin I
  • Allyl homolog of cinerin I
  • Allylrethronyl dl-cis-trans-chrysanthemate
  • alpha-dl-trans-Allethrin
  • Binamin forte
  • Bioaletrina
  • Bioaletrina [Portuguese]
  • bioallethrin
  • Bioallethrin [BAN]
  • Bioallethrin [BSI]
  • Bioaltrina [Portuguese]
  • BRN 2059862
  • C14337
  • Caswell No. 025
  • CCRIS 2494
  • CHEBI:34572
  • Chrysanthemummonocarboxylic acid, 3-allyl-3-methyl-4-oxo-2-cyclopenten-1-yl ester
  • Cinerin I allyl homolog
  • cis-Allethrin
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester, (1-alpha(S*),3-beta)-(+-)-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester, d-trans-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopentene-1-yl ester
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, ester with 2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, ester with 2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one, trans-(.+/-.)-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, (1R)-2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester, (1R,3R)-rel-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, ster with 2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one, trans-(+-)-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, ester with 2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one (VAN) (8CI)
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester, [1R-[1.alpha.(S*),3.beta.]]-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, (1S)-2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester, (1R,3R)-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, 2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester, (1R-(1alpha(S*),3beta))-
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methylpropenyl)-, (+)-(E)-, ester with (+)-2-allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one
  • Cyclopropanecarboxylic acid, 2,2-dimethyl-3-(2-methyl-1-propenyl)-, (1R)-2-methyl-4-oxo-3-(2-propenyl)-2-cyclopenten-1-yl ester. (1S.3S)-rel-
  • D,L-2-Allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one-D,L-chrysanthemum monocarboxylate
  • D-Allethrin
  • d-Allethrolone chrysanthemumate
  • d-Allethrolone d-trans-chrysanthemumate
  • d-cis,trans-Allethrin
  • d-T-Allethrin
  • D-trans Allethrin
  • d-trans-(1-Methyl-2-allyl-3-oxo-1-cyclopenten-5-yl)chrysanthemumate
  • Depallethrin
  • dl-2-Allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one ester of d-trans-2,2-dimethyl-3-(2-methylpropenyl)
  • dl-2-Allyl-4-hydroxy-3-methyl-2-cyclopenten-1-one ester of dl cis/trans 2,2-dimethyl-3-(2-methylpropenyl)-cyclopropanecarboxylic acid
  • dl-3-Allyl-2-methyl-4-oxocyclopent-2-enyl dl-cis trans chrysanthemate
  • EINECS 209-542-4
  • EINECS 249-013-5
  • ENT 16275
  • ENT 17,510
  • ENT 17510
  • EPA Pesticide Chemical Code 004001
  • EPA Pesticide Chemical Code 004003
  • Esbioallethrin
  • Esbiol
  • Esbiol concentrate 90%
  • Esbiol TM Intermediate 3336
  • esbiothrin
  • Esdepallethrine
  • Exthrin
  • FDA 1446
  • FMC 249
  • HSDB 1511
  • Matox
  • MGK allethrin concentrate
  • NCGC00163953-01
  • Necarboxylic acid
  • NIA 249
  • NSC 11782
  • NSC11782
  • OMS 3045
  • Pallethrine
  • Pynamin
  • Pynamin-forte
  • Pyresin
  • Pyresyn
  • Pyrethrin
  • RU 16121
  • RU 27436
  • S-BIOALLETHRIN
  • trans-(+)-Allethrin
  • trans-Allethrin
  • Wasp Killer II
  • Wasp Stopper CF
  • WLN: L5V BUTJ B2U1 C1 DOV- BL3TJ A1 A1 C1UY1&1

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 4 Starlite/ChEMBL No references
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL No references
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL No references
Rattus norvegicus Nuclear receptor subfamily 1 group I member 2 Starlite/ChEMBL No references
Homo sapiens retinoid X receptor, alpha Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens androgen receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni retinoic acid receptor RXR Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus granulosus retinoic acid receptor rxr beta a Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha Get druggable targets OG5_130073 All targets in OG5_130073
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K08524 nuclear receptor, subfamily 2, group B, member 1, putative Get druggable targets OG5_130073 All targets in OG5_130073
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 378 aa 25.4 %
Brugia malayi photoreceptor-specific nuclear receptor Nuclear receptor subfamily 1 group I member 2   431 aa 378 aa 25.1 %
Brugia malayi Nuclear hormone receptor E75 Nuclear receptor subfamily 1 group I member 2   431 aa 359 aa 22.0 %
Echinococcus granulosus ecdysone induced protein 78C Nuclear receptor subfamily 1 group I member 2   431 aa 348 aa 28.2 %
Brugia malayi ecdysteroid receptor Nuclear receptor subfamily 1 group I member 2   431 aa 394 aa 26.9 %
Onchocerca volvulus C-mannosyltransferase dpy-19 homolog Nuclear receptor subfamily 1 group I member 2   431 aa 397 aa 29.2 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 381 aa 26.2 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 417 aa 24.0 %
Loa Loa (eye worm) hypothetical protein Nuclear receptor subfamily 1 group I member 2   431 aa 400 aa 29.8 %
Echinococcus multilocularis ecdysone induced protein 78C Nuclear receptor subfamily 1 group I member 2   431 aa 348 aa 28.2 %
Brugia malayi ecdysteroid receptor retinoid X receptor, alpha 435 aa 352 aa 23.9 %
Schistosoma japonicum Probable nuclear hormone receptor HR3, putative Nuclear receptor subfamily 1 group I member 2   431 aa 487 aa 24.4 %
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 Nuclear receptor subfamily 1 group I member 2   431 aa 440 aa 23.0 %
Brugia malayi nuclear hormone receptor Nuclear receptor subfamily 1 group I member 2   431 aa 394 aa 26.4 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 379 aa 24.5 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 390 aa 24.6 %
Schistosoma mansoni retinoic acid receptor RXR Nuclear receptor subfamily 1 group I member 2   431 aa 412 aa 25.5 %
Onchocerca volvulus Nuclear receptor subfamily 1 group I member 2   431 aa 424 aa 24.1 %
Echinococcus granulosus ecdysone induced protein 78C nuclear receptor subfamily 1, group H, member 4 476 aa 402 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Echinococcus multilocularis Niemann Pick C1 protein 0.0885 0.1684 0.1679
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0052 0.0039 0.0199
Loa Loa (eye worm) hypothetical protein 0.0093 0.0122 0.0143
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.001 0.0119
Onchocerca volvulus 0.0976 0.1863 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0024
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0052 0.0039 0.162
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.001 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.018 0.0217
Loa Loa (eye worm) hypothetical protein 0.0325 0.058 0.0712
Loa Loa (eye worm) TWK-7 protein 0.0136 0.0206 0.0247
Plasmodium vivax potassium channel, putative 0.0136 0.0206 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0017 0.0038
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0037 0.001 0.0119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0106 0.01
Loa Loa (eye worm) steroid hormone receptor 0.0085 0.0106 0.0123
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0015 0.0032
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.008 0.0943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0085 0.0106 0.0123
Brugia malayi Pre-SET motif family protein 0.0123 0.018 0.1068
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0052 0.0039 0.0174
Schistosoma mansoni hypothetical protein 0.0065 0.0066 0.0074
Loa Loa (eye worm) patched family protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.0342 0.0416
Loa Loa (eye worm) hypothetical protein 0.4112 0.8051 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0266 0.0462 0.0456
Mycobacterium ulcerans lipase LipD 0.0072 0.008 0.0442
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.001 0.0016
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Echinococcus granulosus tar DNA binding protein 0.007 0.0076 0.0088
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0026 0.0934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Echinococcus granulosus GPCR family 2 0.0065 0.0066 0.0074
Echinococcus granulosus tumor protein p63 0.1024 0.1958 0.2427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0125 0.0184 0.2181
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0136 0.0206 1
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0136 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0083 0.0094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0141 0.0215 0.021
Toxoplasma gondii ion channel protein 0.0136 0.0206 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0215 0.026
Toxoplasma gondii ion channel protein 0.0136 0.0206 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.0136 0.0206 0.1226
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0039 0.0174
Brugia malayi nuclear receptor NHR-88 0.0085 0.0106 0.061
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0012
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0379 0.0685 0.068
Echinococcus granulosus Niemann Pick C1 protein 0.0619 0.1159 0.1434
Loa Loa (eye worm) hypothetical protein 0.0065 0.0066 0.0073
Brugia malayi hypothetical protein 0.0038 0.0012 0.0029
Trichomonas vaginalis esterase, putative 0.0072 0.008 0.0391
Onchocerca volvulus 0.0038 0.0012 0.0009
Loa Loa (eye worm) hypothetical protein 0.0072 0.008 0.009
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0017 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.008 0.0092
Schistosoma mansoni transcription factor LCR-F1 0.0228 0.0387 0.0473
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0037 0.001 0.0005
Entamoeba histolytica Ran family GTPase 0.0045 0.0026 0.0161
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.001 0.0171
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0017 0.0014
Schistosoma mansoni nuclear hormone receptor 0.004 0.0017 0.0014
Schistosoma mansoni ran 0.0045 0.0026 0.0025
Onchocerca volvulus 0.0038 0.0012 0.0009
Echinococcus multilocularis calcium activated potassium channel variant 0.0136 0.0206 0.02
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0085 0.0106 0.0125
Schistosoma mansoni ran 0.0045 0.0026 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0027 0.012
Echinococcus multilocularis twik family of potassium channels 0.0136 0.0206 0.02
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.008 0.0448
Mycobacterium tuberculosis Conserved protein 0.0072 0.008 0.0943
Brugia malayi hypothetical protein 0.004 0.0017 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0085 0.0106 0.0125
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.001 0.0151
Plasmodium vivax hypothetical protein, conserved 0.0072 0.008 0.3553
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.008 0.0442
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0037 0.001 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0085 0.0106 0.0123
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0085 0.0106 0.0125
Brugia malayi Nuclear hormone receptor E75 0.004 0.0017 0.0061
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0136 0.0206 0.1226
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Echinococcus granulosus potassium channel subfamily K 0.0136 0.0206 0.0249
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0039 0.162
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.0136 0.0206 0.1226
Leishmania major importin beta-1 subunit, putative 0.0049 0.0035 0.1384
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.0184 0.1108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0112 0.1324
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0037 0.001 0.0119
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0037 0.001 0.0119
Schistosoma mansoni zinc finger protein 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0093 0.0122 0.0143
Onchocerca volvulus 0.0136 0.0206 0.1057
Brugia malayi Augmenter of liver regeneration 0.0037 0.0011 0.0025
Echinococcus multilocularis microtubule associated protein 2 0.2798 0.5458 0.5455
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0024
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0106 0.061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Schistosoma mansoni hypothetical protein 0.0647 0.1214 0.1502
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Trypanosoma cruzi calcium-activated potassium channel, putative 0.0136 0.0206 1
Loa Loa (eye worm) patched family protein 0.0038 0.0012 0.0006
Brugia malayi RNA binding protein 0.007 0.0076 0.0428
Schistosoma mansoni alpha glucosidase 0.0035 0.0007 0.0002
Brugia malayi topoisomerase 0.0052 0.0039 0.0199
Brugia malayi RNA, U transporter 1 0.0172 0.0278 0.1668
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0017 0.0012
Schistosoma mansoni hypothetical protein 0.4112 0.8051 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.001 0.0006
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.008 0.0943
Schistosoma mansoni ap endonuclease 0.0039 0.0015 0.0012
Onchocerca volvulus 0.004 0.0017 0.0038
Echinococcus multilocularis protein dispatched 1 0.0303 0.0536 0.0531
Toxoplasma gondii ABC1 family protein 0.0072 0.008 0.3651
Trichomonas vaginalis replication factor C large subunit, putative 0.0052 0.0039 0.0174
Loa Loa (eye worm) glutaminase 2 0.0834 0.1584 0.196
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Onchocerca volvulus 0.0123 0.018 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0085 0.0106 0.061
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.008 0.0943
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0125 0.0184 0.1108
Toxoplasma gondii propionate-CoA ligase 0.0037 0.001 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.008 0.0391
Echinococcus granulosus potassium channel subfamily K 8 0.0136 0.0206 0.0249
Echinococcus granulosus Niemann Pick C1 protein 0.0885 0.1684 0.2085
Schistosoma mansoni calcium-activated potassium channel 0.2653 0.5173 0.6422
Schistosoma mansoni cellular tumor antigen P53 0.015 0.0233 0.0283
Echinococcus granulosus histone lysine methyltransferase setb 0.0141 0.0215 0.026
Brugia malayi protein C24B5.3 0.0038 0.0012 0.0029
Echinococcus multilocularis replication factor c subunit 1 0.0052 0.0039 0.0034
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi hypothetical protein 0.004 0.0017 0.0061
Brugia malayi hypothetical protein 0.0168 0.0269 0.1613
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0106 0.0125
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.0136 0.0206 0.1226
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0035 0.0148
Echinococcus granulosus ecdysone induced protein 78C 0.0085 0.0106 0.0125
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.0136 0.0206 0.1226
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.0184 0.1108
Echinococcus multilocularis thyroid hormone receptor alpha 0.0464 0.0853 0.0848
Brugia malayi nuclear hormone receptor 0.004 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0106 0.01
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.0136 0.0206 0.0247
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.008 0.0391
Loa Loa (eye worm) TWK-28 protein 0.0136 0.0206 0.0247
Echinococcus multilocularis expressed conserved protein 0.0582 0.1085 0.108
Brugia malayi hypothetical protein 0.0052 0.0039 0.0199
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.008 0.3651
Onchocerca volvulus 0.0125 0.0184 0.0941
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0136 0.0206 0.02
Brugia malayi hypothetical protein 0.0045 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Loa Loa (eye worm) hypothetical protein 0.0205 0.0342 0.0416
Schistosoma mansoni thyroid hormone receptor 0.0464 0.0853 0.1053
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0003 0.0034
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.0184 0.8914
Echinococcus multilocularis potassium channel subfamily K 8 0.0136 0.0206 0.02
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi hypothetical protein 0.0228 0.0387 0.234
Brugia malayi AMP-binding enzyme family protein 0.0037 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Giardia lamblia Hypothetical protein 0.0136 0.0206 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0085 0.0106 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0206 1
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.0136 0.0206 0.1226
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0037 0.001 0.0151
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.004 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.0184 0.1539
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.0184 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0026 0.0025
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.0136 0.0206 0.1226
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0011 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0085 0.0106 0.061
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Schistosoma mansoni steroid hormone receptor ad4bp 0.0085 0.0106 0.0125
Toxoplasma gondii patched family protein 0.0038 0.0012 0.0233
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0037 0.001 0.0119
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0037 0.001 0.0004
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.0206 0.1072
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0159 0.0252 0.0246
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Plasmodium falciparum acyl-CoA synthetase 0.0093 0.0122 0.5713
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.1255 0.2414 0.2992
Brugia malayi Bromodomain containing protein 0.0078 0.0092 0.0522
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0112 0.1324
Schistosoma mansoni retinoic acid receptor RXR 0.0204 0.0341 0.0417
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0037 0.001 0.0018
Brugia malayi hypothetical protein 0.0077 0.009 0.0509
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0085 0.0106 0.0125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0204 0.0341 0.0417
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0251 0.0245
Loa Loa (eye worm) glutaminase 0.0834 0.1584 0.196
Schistosoma mansoni acetyl-CoA synthetase 0.0037 0.001 0.0005
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0037 0.001 0.0399
Echinococcus granulosus lysosomal alpha glucosidase 0.0159 0.0251 0.0304
Schistosoma mansoni hypothetical protein 0.0379 0.0685 0.0844
Leishmania major ion transport protein-like protein 0.0136 0.0206 1
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.008 0.0391
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0085 0.0106 0.0125
Mycobacterium ulcerans transmembrane cation transporter 0.0136 0.0206 0.1245
Plasmodium vivax SET domain protein, putative 0.0123 0.018 0.8688
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.001 0.0151
Schistosoma mansoni importin beta-1 0.0061 0.0057 0.0064
Onchocerca volvulus 0.0136 0.0206 0.1057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0159 0.0251 0.1501
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0017 0.0011
Brugia malayi DKFZp564C0469 protein 0.0052 0.0039 0.0199
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.0206 0.1072
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0026 0.0934
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0228 0.0387 0.0381
Loa Loa (eye worm) hypothetical protein 0.0266 0.0462 0.0565
Echinococcus granulosus twik family of potassium channels 0.0136 0.0206 0.0249
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0026 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0085 0.0106 0.0125
Schistosoma mansoni tar DNA-binding protein 0.007 0.0076 0.0088
Plasmodium falciparum lipid/sterol:H+ symporter 0.0038 0.0012 0.0084
Mycobacterium tuberculosis Conserved protein 0.0072 0.008 0.0943
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0026 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.008 0.0391
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.0206 0.1072
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0027 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.0184 0.8914
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0037 0.001 0.0026
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.008 0.0092
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0057 0.2521
Loa Loa (eye worm) beta-lactamase 0.0072 0.008 0.009
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0093 0.0122 0.0143
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0057 0.2521
Echinococcus multilocularis lysosomal alpha glucosidase 0.0159 0.0251 0.0245
Echinococcus multilocularis small conductance calcium activated potassium 0.4112 0.8051 0.805
Toxoplasma gondii patched family protein 0.0038 0.0012 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0039 0.0174
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0026 0.0795
Trichomonas vaginalis ran, putative 0.0045 0.0026 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0037 0.001 0.0018
Loa Loa (eye worm) DR-78 0.004 0.0017 0.0012
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.0171
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0028 0.0027
Echinococcus multilocularis tumor protein p63 0.1024 0.1958 0.1953
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Plasmodium vivax potassium channel, putative 0.0136 0.0206 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.0072 0.008 0.009
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0035 0.0148
Schistosoma mansoni hypothetical protein 0.0256 0.0443 0.0543
Mycobacterium leprae Probable lipase LipE 0.0072 0.008 0.4233
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.0136 0.0206 0.2437
Mycobacterium ulcerans glutaminase 0.0834 0.1584 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi ecdysone receptor 0.004 0.0017 0.0061
Echinococcus multilocularis potassium channel subfamily K 8 0.0136 0.0206 0.02
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0085 0.0106 0.01
Trichomonas vaginalis glutaminase, putative 0.0834 0.1584 0.8496
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0039 0.0174
Entamoeba histolytica hypothetical protein 0.0228 0.0387 0.3294
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.009 0.4149
Toxoplasma gondii exonuclease III APE 0.0039 0.0015 0.0408
Leishmania major hypothetical protein, conserved 0.0072 0.008 0.3651
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0007 0.0001
Brugia malayi tailless protein 0.004 0.0017 0.0061
Schistosoma mansoni coup transcription factor 0.0085 0.0106 0.0125
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0026 0.0548
Loa Loa (eye worm) hypothetical protein 0.0061 0.0057 0.0062
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.0171
Plasmodium vivax replication factor C subunit 1, putative 0.0052 0.0039 0.1492
Trypanosoma cruzi ion transport protein, putative 0.0136 0.0206 1
Echinococcus granulosus small conductance calcium activated potassium 0.4112 0.8051 1
Schistosoma mansoni chromosome transmission fidelity factor 0.0052 0.0039 0.0042
Schistosoma mansoni microtubule-associated protein tau 0.2798 0.5458 0.6777
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0017 0.0011
Onchocerca volvulus 0.0038 0.0012 0.0009
Schistosoma mansoni bromodomain containing protein 0.0066 0.0068 0.0077
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0011 0.0207
Entamoeba histolytica hypothetical protein 0.0049 0.0035 0.0239
Brugia malayi Myosin head containing protein 0.0038 0.0012 0.0029
Brugia malayi Niemann-Pick C1 protein precursor 0.0619 0.1159 0.7104
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.006 0.0055
Brugia malayi hypothetical protein 0.0038 0.0012 0.0029
Loa Loa (eye worm) oxidoreductase 0.0037 0.001 0.0004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0066 0.006
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0015 0.0044
Brugia malayi hypothetical protein 0.0136 0.0206 0.1226
Brugia malayi steroid hormone receptor 0.0085 0.0106 0.061
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.008 0.009
Schistosoma mansoni hypothetical protein 0.0256 0.0443 0.0543
Mycobacterium ulcerans beta-lactamase 0.0072 0.008 0.0442
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0011 0.0207
Echinococcus granulosus sterol regulatory element binding protein 0.0266 0.0462 0.0567
Trichomonas vaginalis antibiotic synthetase, putative 0.0037 0.001 0.0016
Brugia malayi AMP-binding enzyme family protein 0.0037 0.001 0.0018
Echinococcus multilocularis snurportin 1 0.0647 0.1214 0.1209
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0093 0.0122 0.0143
Brugia malayi nuclear receptor RXR 0.004 0.0017 0.0061
Plasmodium vivax importin-beta 2, putative 0.0061 0.0057 0.2407
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0039 0.0174
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.001 0.0018
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Echinococcus granulosus TWiK family of potassium channels protein 7 0.0136 0.0206 0.0249
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0015 0.001
Leishmania major hypothetical protein, conserved 0.0037 0.0011 0.0207
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0125 0.0184 0.1108
Treponema pallidum DNA ligase (lig) 0.0052 0.0039 1
Leishmania major potassium channel subunit-like protein 0.0136 0.0206 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0085 0.0106 0.0125
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.0136 0.0206 0.1226
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Onchocerca volvulus 0.0072 0.008 0.0376
Onchocerca volvulus 0.015 0.0233 0.1205
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.004
Loa Loa (eye worm) RNA binding protein 0.007 0.0076 0.0086
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.0171
Brugia malayi Patched protein homolog 1 0.0038 0.0012 0.0029
Onchocerca volvulus 0.0038 0.0012 0.0009
Trichomonas vaginalis set domain proteins, putative 0.0976 0.1863 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0026 0.0934
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.001 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0028 0.0028
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0027 0.0024
Echinococcus multilocularis twik family of potassium channels 0.0136 0.0206 0.02
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0085 0.0106 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi ecdysteroid receptor 0.0085 0.0106 0.061
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0647 0.1214 0.1501
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.0342 0.2064
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0037 0.001 0.0119
Onchocerca volvulus 0.0072 0.008 0.0376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0028 0.0028
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0015 0.0261
Brugia malayi Patched related family protein 12 0.0038 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0026 0.0795
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0015 0.1635
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.001 0.0119
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Onchocerca volvulus 0.0136 0.0206 0.1057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi CHE-14 protein 0.0266 0.0462 0.2804
Schistosoma mansoni hypothetical protein 0.0256 0.0443 0.0543
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.001 0.0018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.008 0.0442
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi Patched related family protein 10 0.0038 0.0012 0.0029
Echinococcus granulosus replication factor c subunit 1 0.0052 0.0039 0.0042
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0085 0.0106 0.0125
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0037 0.001 0.0119
Onchocerca volvulus 0.0038 0.0012 0.0009
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.0136 0.0206 0.1726
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0027 0.0026
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.006 0.0068
Schistosoma mansoni hypothetical protein 0.0228 0.0387 0.0473
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.0136 0.0206 0.0247
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.001 0.0171
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Brugia malayi hypothetical protein 0.005 0.0036 0.0177
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0028 0.0023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.0342 0.2064
Trypanosoma cruzi hypothetical protein, conserved 0.0136 0.0206 1
Leishmania major calcium/potassium channel (CAKC), putative 0.0136 0.0206 1
Onchocerca volvulus Protein patched homolog 0.0038 0.0012 0.0009
Loa Loa (eye worm) patched family protein 0.0038 0.0012 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0015 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0085 0.0106 0.061
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Echinococcus granulosus microtubule associated protein 2 0.2798 0.5458 0.6777
Leishmania major hypothetical protein, conserved 0.0077 0.009 0.4149
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.001 0.0003
Echinococcus multilocularis tar DNA binding protein 0.007 0.0076 0.0071
Loa Loa (eye worm) hypothetical protein 0.0042 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0141 0.0215 0.0259
Brugia malayi Nuclear hormone receptor E75 0.004 0.0017 0.0061
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0125 0.0184 0.1108
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0026 0.0114
Toxoplasma gondii hypothetical protein 0.0038 0.0012 0.0233
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0015 0.0408
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0015 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0085 0.0106 0.061
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.001 0.0029
Echinococcus granulosus twik family of potassium channels 0.0136 0.0206 0.0249
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0035 0.0148
Schistosoma mansoni inositol monophosphatase 0.0037 0.001 0.0006
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0015 0.0009
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0024
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0228 0.0387 0.0473
Schistosoma mansoni hypothetical protein 0.0065 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.1323 0.2548 0.3158
Mycobacterium leprae conserved hypothetical protein 0.0072 0.008 0.4233
Schistosoma mansoni topbp1 0.0052 0.0039 0.0042
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.0136 0.0206 0.1226
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.0214 0.1276
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0106 0.061
Brugia malayi Pax transcription activation domain interacting protein 0.0052 0.0039 0.0199
Schistosoma mansoni tar DNA-binding protein 0.007 0.0076 0.0088
Trypanosoma cruzi FHA domain containing protein, putative 0.0052 0.0039 0.162
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.004
Leishmania major GTP-binding protein, putative 0.0045 0.0026 0.0934
Schistosoma mansoni hypothetical protein 0.014 0.0214 0.0259
Echinococcus multilocularis GPCR, family 2 0.0065 0.0066 0.006
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0052 0.0039 0.2009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0028 0.0023
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.004
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0007 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.0106 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.009 0.4149
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0136 0.0206 0.1226
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0215 0.026
Schistosoma mansoni tar DNA-binding protein 0.007 0.0076 0.0088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0015 0.0261
Echinococcus granulosus Protein patched homolog 1 0.0266 0.0462 0.0567
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0619 0.1159 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Echinococcus granulosus nuclear factor of activated T cells 5 0.0089 0.0113 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.0125 0.0184 0.022
Loa Loa (eye worm) hypothetical protein 0.0619 0.1159 0.1432
Onchocerca volvulus 0.0136 0.0206 0.1057
Schistosoma mansoni calcium-activated potassium channel 0.4112 0.8051 1
Loa Loa (eye worm) inositol-1 0.0037 0.001 0.0004
Echinococcus multilocularis FTZ F1 alpha 0.0085 0.0106 0.01
Onchocerca volvulus 0.0038 0.0012 0.0009
Schistosoma mansoni hypothetical protein 0.0256 0.0443 0.0543
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.009 0.4149
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0052 0.0039 0.0174
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0027 0.0021
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0015 0.0408
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Onchocerca volvulus Bile acid receptor homolog 0.0085 0.0106 0.0518
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0136 0.0206 0.1226
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0085 0.0106 0.061
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Brugia malayi protein C24B5.3 0.0038 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Onchocerca volvulus 0.0092 0.0119 0.0586
Brugia malayi hypothetical protein 0.0052 0.0039 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0085 0.0106 0.061
Loa Loa (eye worm) hypothetical protein 0.015 0.0233 0.0281
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Schistosoma mansoni nuclear receptor 0.004 0.0017 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.046 0.0845 1
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0011 0.0058
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0028 0.0132
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0085 0.0106 0.0125
Schistosoma mansoni hypothetical protein 0.0136 0.0206 0.0249
Loa Loa (eye worm) uncoordinated protein 58 0.0136 0.0206 0.0247
Loa Loa (eye worm) hypothetical protein 0.0072 0.008 0.009
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.0136 0.0206 0.1226
Brugia malayi nuclear receptor RXR 0.0045 0.0027 0.012
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.0136 0.0206 0.1226
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0017 0.0014
Schistosoma mansoni patched 1 0.0266 0.0462 0.0567
Schistosoma mansoni nuclear hormone receptor 0.004 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Plasmodium falciparum potassium channel 0.0136 0.0206 1
Brugia malayi TAR-binding protein 0.007 0.0076 0.0428
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0037 0.001 0.0151
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0024
Schistosoma mansoni calcium-activated potassium channel 0.0136 0.0206 0.0249
Plasmodium vivax acyl-CoA synthetase, putative 0.0093 0.0122 0.5713
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0011 0.0006
Trypanosoma brucei calcium-activated potassium channel, putative 0.0136 0.0206 1
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0015 0.005
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0037 0.001 0.0151
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0052 0.0039 0.0174
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.018 0.8707
Brugia malayi AMP-binding enzyme family protein 0.0125 0.0184 0.1093
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Brugia malayi Inositol-1 0.0037 0.001 0.0021
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0017 0.0011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0028 0.0028
Schistosoma mansoni topbp1 0.0052 0.0039 0.0042
Leishmania major hypothetical protein, conserved 0.0136 0.0206 1
Schistosoma mansoni alpha-glucosidase 0.0137 0.0207 0.025
Onchocerca volvulus 0.0136 0.0206 0.1057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.008 0.0074
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.008 0.0943
Brugia malayi nuclear hormone receptor 0.0085 0.0106 0.061
Plasmodium vivax patched family protein, putative 0.0038 0.0012 0.0084
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0017 0.0014
Trypanosoma cruzi ion transport protein, putative 0.0136 0.0206 1
Echinococcus multilocularis potassium channel subfamily K 0.0136 0.0206 0.02
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0076 0.0428
Onchocerca volvulus 0.0072 0.008 0.0376
Loa Loa (eye worm) hypothetical protein 0.0072 0.008 0.009
Brugia malayi Pre-SET motif family protein 0.0857 0.1629 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.004
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.0136 0.0206 0.0247
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0026 0.0934
Brugia malayi AMP-binding enzyme family protein 0.0125 0.0184 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0039 0.0174
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0052 0.0039 0.028
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0052 0.0039 0.0174
Brugia malayi AMP-binding enzyme family protein 0.0037 0.001 0.0018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0011 0.0007
Schistosoma mansoni tar DNA-binding protein 0.007 0.0076 0.0088
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.001 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0125 0.0184 0.1108
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0052 0.0039 0.162
Entamoeba histolytica hypothetical protein 0.0228 0.0387 0.3294
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi Importin beta-1 subunit 0.0061 0.0057 0.0309
Onchocerca volvulus 0.0136 0.0206 0.1057
Toxoplasma gondii ATPase, AAA family protein 0.0052 0.0039 0.1621
Schistosoma mansoni glutaminase 0.0834 0.1584 0.1961
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.008 0.0943
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Loa Loa (eye worm) hypothetical protein 0.014 0.0214 0.0257
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.001 0.0006
Brugia malayi hypothetical protein 0.0136 0.0206 0.1226
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0015 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0106 0.061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0125 0.0184 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0125 0.0184 0.2181
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0037 0.001 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0085 0.0106 0.0123
Brugia malayi nuclear receptor NHR-88 0.004 0.0017 0.0061
Onchocerca volvulus Protein patched homolog 0.0038 0.0012 0.0009
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.008 0.0943
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0066 0.0073
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0093 0.0122 0.1443
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.008 0.3651
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0052 0.0039 0.162
Mycobacterium ulcerans acyl-CoA synthetase 0.0125 0.0184 0.1108
Loa Loa (eye worm) hypothetical protein 0.0077 0.009 0.0103
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0057 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0017 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0066 0.0074
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.0136 0.0206 0.1226
Trypanosoma cruzi hypothetical protein, conserved 0.0052 0.0039 0.162
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.0206 0.1072
Onchocerca volvulus 0.0136 0.0206 0.1057
Mycobacterium ulcerans hypothetical protein 0.0125 0.0184 0.1108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0066 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0106 0.061
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0037 0.001 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0619 0.1159 0.1154
Echinococcus multilocularis protein patched 0.0266 0.0462 0.0456
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi beta-lactamase 0.0072 0.008 0.0448
Brugia malayi hypothetical protein 0.0038 0.0012 0.0029
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0011 0.0207
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0112 0.1324
Entamoeba histolytica hypothetical protein 0.0052 0.0039 0.028
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0168 0.0269 0.0325
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Leishmania major 4-coumarate:coa ligase-like protein 0.0125 0.0184 0.8914
Echinococcus granulosus expressed conserved protein 0.0582 0.1085 0.1342
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0017 0.0061
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.0136 0.0206 0.02
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Loa Loa (eye worm) hypothetical protein 0.0125 0.0184 0.022
Onchocerca volvulus Protein ultraspiracle homolog 0.0085 0.0106 0.0518
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0085 0.0106 0.0518
Onchocerca volvulus 0.0085 0.0106 0.0518
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0159 0.0251 0.0303
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.004
Brugia malayi beta-lactamase family protein 0.0072 0.008 0.0448
Mycobacterium tuberculosis Conserved protein 0.0072 0.008 0.0943
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0037 0.001 0.0151
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0266 0.0462 0.0565
Echinococcus granulosus nibrin 0.0052 0.0039 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0106 0.061
Brugia malayi nuclear receptor NHR-67 0.004 0.0017 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0125 0.0184 0.1093
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.008 0.0391
Loa Loa (eye worm) patched family protein 0.0038 0.0012 0.0006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0011 0.0207
Loa Loa (eye worm) hypothetical protein 0.0072 0.008 0.009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0085 0.0106 0.061
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.008 0.0943
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.008 0.3651
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0066 0.036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.001 0.0151
Brugia malayi photoreceptor-specific nuclear receptor 0.0085 0.0106 0.061
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0037 0.001 0.0399
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0066 0.036
Loa Loa (eye worm) patched family protein 0.0038 0.0012 0.0006
Brugia malayi hypothetical protein 0.0038 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Loa Loa (eye worm) TAR-binding protein 0.007 0.0076 0.0086
Schistosoma mansoni alpha-glucosidase 0.0137 0.0207 0.025
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0136 0.0206 1
Echinococcus granulosus snurportin 1 0.0647 0.1214 0.1502
Toxoplasma gondii patched family protein 0.0038 0.0012 0.0233
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0057 0.2521
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0085 0.0106 0.0123
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Onchocerca volvulus 0.004 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0015 0.0408
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0011 0.0207
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0011 0.0005
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0136 0.0206 0.1072
Giardia lamblia Replication factor C, subunit 1 0.0052 0.0039 0.1264
Leishmania major acetyl-CoA synthetase, putative 0.0037 0.001 0.0151
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0629 0.1178 0.1457
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0066 0.006
Schistosoma mansoni tar DNA-binding protein 0.007 0.0076 0.0088
Mycobacterium ulcerans ion transport protein 0.0136 0.0206 0.1245
Loa Loa (eye worm) hypothetical protein 0.0093 0.0122 0.0143
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.0136 0.0206 0.1226
Echinococcus multilocularis ecdysone induced protein 78C 0.0085 0.0106 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0017 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.0085 0.0106 0.0125
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0017 0.0011
Leishmania major hypothetical protein, conserved 0.0136 0.0206 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0125 0.0184 0.1539
Schistosoma mansoni hypothetical protein 0.0065 0.0066 0.0074
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.0136 0.0206 0.1226
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0085 0.0106 0.0125
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0017 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0085 0.0106 0.01
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0017 0.0014
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0857 0.1629 0.2016
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.018 0.0217
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0015 0.007
Echinococcus multilocularis nibrin 0.0052 0.0039 0.0034
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.0136 0.0206 0.1226
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Plasmodium falciparum potassium channel 0.0136 0.0206 1
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0015 0.0044
Brugia malayi hypothetical protein 0.0045 0.0027 0.012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0017 0.0061
Brugia malayi beta-lactamase family protein 0.0072 0.008 0.0448
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0106 0.061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0171 0.0206
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.009 0.4149
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0136 0.0206 1
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0011 0.0207
Schistosoma mansoni ap endonuclease 0.0039 0.0015 0.0012
Schistosoma mansoni nuclear receptor 0.004 0.0017 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0106 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.009 0.406
Schistosoma mansoni thyroid hormone receptor 0.0464 0.0853 0.1053
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0037 0.001 0.0151
Loa Loa (eye worm) hypothetical protein 0.1398 0.2697 0.3344
Echinococcus granulosus potassium channel subfamily K 8 0.0136 0.0206 0.0249
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.009 0.406
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0085 0.0106 0.061
Echinococcus granulosus importin subunit beta 1 0.0061 0.0057 0.0064
Loa Loa (eye worm) hypothetical protein 0.0044 0.0025 0.0023
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0076 0.0086
Schistosoma mansoni hypothetical protein 0.0065 0.0066 0.0074
Loa Loa (eye worm) hypothetical protein 0.0045 0.0027 0.0024
Echinococcus granulosus FTZ F1 alpha 0.0085 0.0106 0.0125
Entamoeba histolytica acyl-coA synthetase, putative 0.0125 0.0184 0.1539
Loa Loa (eye worm) hypothetical protein 0.0072 0.008 0.009
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.009 0.406
Toxoplasma gondii patched family protein 0.0038 0.0012 0.0233
Brugia malayi conserved hypotetical protein 0.004 0.0017 0.0061
Brugia malayi Bromodomain containing protein 0.004 0.0016 0.0057
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.001 0.0119
Schistosoma mansoni calcium-activated potassium channel 0.0136 0.0206 0.0249
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0085 0.0106 0.0123
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Plasmodium falciparum replication factor C subunit 1, putative 0.0052 0.0039 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0462 0.2451
Schistosoma mansoni twik family of potassium channels-related 0.0136 0.0206 0.0249
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0093 0.0122 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0027 0.0026
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0106 0.061
Schistosoma mansoni DNA ligase IV 0.0052 0.0039 0.0042
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0379 0.0685 0.0844
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.008 0.0092
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0052 0.0039 1
Brugia malayi Patched related family protein 4 0.0038 0.0012 0.0029
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0037 0.001 0.0151
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0093 0.0122 0.0711
Onchocerca volvulus 0.0038 0.0012 0.0009
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0089 0.0113 0.0107
Onchocerca volvulus 0.0136 0.0206 0.1057
Entamoeba histolytica hypothetical protein 0.0228 0.0387 0.3294
Mycobacterium ulcerans hypothetical protein 0.0072 0.008 0.0442
Loa Loa (eye worm) hypothetical protein 0.0038 0.0012 0.0006
Plasmodium falciparum importin beta, putative 0.0061 0.0057 0.2407
Echinococcus granulosus calcium activated potassium channel variant 0.0136 0.0206 0.0249
Loa Loa (eye worm) hypothetical protein 0.004 0.0017 0.0012
Onchocerca volvulus 0.0168 0.0269 0.1396
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0037 0.001 0.0119
Brugia malayi Patched family protein 0.0038 0.0012 0.0029
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0035 0.1384
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0037 0.001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0136 0.0206 0.0247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.018 0.0175
Loa Loa (eye worm) hypothetical protein 0.0037 0.001 0.0004
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0011 0.0005
Brugia malayi glutaminase DH11.1 0.0834 0.1584 0.972
Loa Loa (eye worm) hypothetical protein 0.0125 0.0184 0.022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0088 0.0112 0.1324
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0037 0.001 0.0119
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0052 0.0039 0.0186
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0017 0.0061
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0136 0.0206 0.0249
Onchocerca volvulus 0.0052 0.0039 0.0158
Entamoeba histolytica hypothetical protein 0.0228 0.0387 0.3294

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.002 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of peroxisome proliferator-activated receptor delta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0035 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of farnesoid X receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.005 uM PubChem BioAssay. qHTS assay for small molecule activators of the p53 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.1737 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2301 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.4212 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.2678 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1955 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of farnesoid X receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.0258 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 43.6412 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 46.2812 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS assay for small molecule agonists of the peroxisome proliferator-activated receptor alpha (PPARalpha) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 51.4856 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 68.5896 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.