Detailed information for compound 558487

Basic information

Technical information
  • TDR Targets ID: 558487
  • Name: (2R,3R)-3,5,7-trihydroxy-2-(2-hydroxyphenyl)c hroman-4-one
  • MW: 288.252 | Formula: C15H12O6
  • H donors: 4 H acceptors: 5 LogP: 1.84 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1cc2O[C@H](c3ccccc3O)[C@H](C(=O)c2c(c1)O)O
  • InChi: 1S/C15H12O6/c16-7-5-10(18)12-11(6-7)21-15(14(20)13(12)19)8-3-1-2-4-9(8)17/h1-6,14-18,20H/t14-,15+/m0/s1
  • InChiKey: BJNCWLSOQIVKIX-LSDHHAIUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R)-3,5,7-trihydroxy-2-(2-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
  • (2R,3R)-3,5,7-trihydroxy-2-(2-hydroxyphenyl)-2,3-dihydrochromen-4-one
  • 2',3,5,7-tetrahydroxyflavanone
  • (2R,3R)-3,5,7-trihydroxy-2-(2-hydroxyphenyl)-4-chromanone
  • 31477-95-9
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(2-hydroxyphenyl)-, (2R-trans)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0069 0.0805 0.266
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0647 0.0647
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0647 0.3319
Echinococcus granulosus dna polymerase kappa 0.0019 0.0031 0.0031
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0029 0.0191 0.0526
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0458 0.5
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0081 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.004 0.0355 0.1157
Brugia malayi Thioredoxin reductase 0.0046 0.0447 0.1401
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0029 0.0191 0.0526
Giardia lamblia PHD finger protein 15 0.003 0.02 0.0413
Schistosoma mansoni hypothetical protein 0.0019 0.0037 0.0037
Brugia malayi Doublecortin family protein 0.0019 0.0037 0.0021
Brugia malayi jmjC domain containing protein 0.0038 0.0325 0.099
Loa Loa (eye worm) glutathione reductase 0.0046 0.0447 0.1464
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1526 0.7483
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0647 0.0647
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0029 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0081 0.0982 0.3251
Brugia malayi Choline O-acetyltransferase 0.0196 0.2735 0.9108
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0029 0.0191 0.0526
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0565 0.0565
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0458 0.23
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0128 0.0317
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0647 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0647 0.0647
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0037 0.0037
Schistosoma mansoni choline o-acyltransferase 0.0196 0.2735 0.2735
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0539 0.1773
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0447 0.9747
Schistosoma mansoni loxhd1 0.0019 0.0037 0.0037
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1526 0.8062
Echinococcus multilocularis carboxylesterase 5A 0.0081 0.0982 0.0982
Schistosoma mansoni hypothetical protein 0.002 0.0054 0.0054
Leishmania major carnitine/choline acetyltransferase, putative 0.0029 0.0191 0.0526
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4128 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0029 0.0191 0.0526
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0128 0.0317
Mycobacterium tuberculosis Conserved protein 0.0025 0.0128 0.052
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1526 0.8062
Plasmodium falciparum phd finger protein, putative 0.003 0.02 0.388
Brugia malayi Bromodomain containing protein 0.0074 0.0869 0.2822
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0565 0.0565
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0325 0.0325
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.064 0.064
Schistosoma mansoni DNA polymerase eta 0.0019 0.0031 0.0031
Onchocerca volvulus 0.0166 0.2281 0.6573
Echinococcus granulosus acetylcholinesterase 0.0081 0.0982 0.0982
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0467 0.0467
Echinococcus multilocularis dna polymerase eta 0.0019 0.0031 0.0031
Plasmodium falciparum glutathione reductase 0.0046 0.0447 0.9747
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0191 0.0538
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0647 0.0647
Echinococcus granulosus geminin 0.0173 0.2395 0.2395
Brugia malayi glutathione reductase 0.0046 0.0447 0.1401
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Onchocerca volvulus 0.0029 0.0191 0.045
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0379 0.0379
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0173 0.2395 0.2395
Brugia malayi hypothetical protein 0.0019 0.0037 0.0021
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0128 0.0317
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0597 0.186
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0029 0.0191 0.0526
Mycobacterium ulcerans hypothetical protein 0.0025 0.0128 0.052
Echinococcus multilocularis choline O acetyltransferase 0.0196 0.2735 0.2735
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.02 0.02
Mycobacterium tuberculosis Probable reductase 0.0105 0.1347 0.7097
Brugia malayi Carboxylesterase family protein 0.0081 0.0982 0.3201
Echinococcus multilocularis L aminoadipate semialdehyde 0.0166 0.2281 0.2281
Trypanosoma brucei hypothetical protein, conserved 0.0218 0.3072 1
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0029 0.0191 0.0526
Loa Loa (eye worm) hypothetical protein 0.0166 0.2281 0.7594
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0447 0.1368
Brugia malayi jmjC domain containing protein 0.0098 0.1238 0.4065
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0191 0.0538
Loa Loa (eye worm) hypothetical protein 0.0038 0.032 0.1038
Onchocerca volvulus 0.0242 0.345 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0037 0.0037
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1886 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0211 0.0607
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0458 0.5764
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1347 0.7097
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.1238 0.1238
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1347 0.7097
Echinococcus granulosus neuropeptide s receptor 0.0454 0.668 0.668
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0082 0.0082
Echinococcus multilocularis RUN 0.0019 0.0037 0.0037
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0447 0.1464
Schistosoma mansoni rab6-interacting 0.0019 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0031 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0467 0.0467
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0458 0.23
Loa Loa (eye worm) PHD-finger family protein 0.003 0.02 0.0639
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0029 0.0191 0.0191
Echinococcus granulosus RUN 0.0019 0.0037 0.0037
Brugia malayi PHD-finger family protein 0.0024 0.0118 0.0292
Onchocerca volvulus 0.0029 0.0191 0.045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0094
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0029 0.0191 0.0191
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0031 0.0031
Loa Loa (eye worm) choline O-acetyltransferase 0.0196 0.2735 0.9114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0211 0.0211
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0283 0.0283
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.064 0.064
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0031
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0931 0.0931
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0277 0.083
Echinococcus granulosus choline O acetyltransferase 0.0196 0.2735 0.2735
Leishmania major hypothetical protein, conserved 0.0218 0.3072 1
Echinococcus multilocularis geminin 0.0173 0.2395 0.2395
Echinococcus multilocularis neuropeptide s receptor 0.0454 0.668 0.668
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1886 1
Echinococcus granulosus neuropeptide receptor A26 0.0454 0.668 0.668
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1886 1
Schistosoma mansoni hypothetical protein 0.0173 0.2395 0.2395
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0647 0.3319
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0128 0.052
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0447 0.0447
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0597 0.3051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Echinococcus granulosus zinc finger protein 0.0019 0.0038 0.0038
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Plasmodium vivax SET domain protein, putative 0.0031 0.0211 0.414
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4128 1
Schistosoma mansoni microtubule-associated protein tau 0.0671 1 1
Schistosoma mansoni rab6-interacting 0.0019 0.0037 0.0037
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Echinococcus multilocularis neuropeptide receptor A26 0.0454 0.668 0.668
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0031 0.0031
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1347 0.7097
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0191 0.0526
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0191 0.0526
Plasmodium vivax hypothetical protein, conserved 0.003 0.02 0.388
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1347 0.623
Loa Loa (eye worm) hypothetical protein 0.0019 0.0037 0.0094
Loa Loa (eye worm) hypothetical protein 0.0196 0.2735 0.9114
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0524 0.1661
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.3 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0597 0.3051
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0597 0.0597
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0031 0.0031
Onchocerca volvulus Alhambra homolog 0.003 0.02 0.0478
Schistosoma mansoni hypothetical protein 0.003 0.02 0.02
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0029 0.0191 0.0526
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1347 0.7097
Loa Loa (eye worm) hypothetical protein 0.0051 0.0526 0.1729
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0191 0.0526
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0166 0.2281 0.2281
Loa Loa (eye worm) hypothetical protein 0.0051 0.0524 0.1722
Loa Loa (eye worm) hypothetical protein 0.0047 0.0467 0.1531
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0379 0.0379
Echinococcus granulosus peregrin 0.0032 0.0236 0.0236
Entamoeba histolytica hypothetical protein 0.0047 0.0458 0.1041
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0029 0.0191 0.0191
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0037 0.0094
Plasmodium falciparum thioredoxin reductase 0.0046 0.0447 0.9747
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.4128 1
Brugia malayi Bromodomain containing protein 0.0038 0.0319 0.0969
Schistosoma mansoni lipoxygenase 0.0019 0.0037 0.0037
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0029 0.0191 0.0538
Brugia malayi PHD-finger family protein 0.003 0.02 0.057
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0458 0.1402
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0211 0.0211
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0166 0.2281 0.7576
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0524 0.1661
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0128 0.0128
Schistosoma mansoni bromodomain containing protein 0.0062 0.0693 0.0693
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0194 0.0194
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0325 0.1056
Loa Loa (eye worm) hypothetical protein 0.012 0.1582 0.5257
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0029 0.0191 0.0526
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0029 0.0191 0.0526
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0597 0.3051
Mycobacterium ulcerans hypothetical protein 0.0025 0.0128 0.052
Brugia malayi hypothetical protein 0.0019 0.0037 0.0021
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0597 0.1905
Loa Loa (eye worm) hypothetical protein 0.0042 0.0384 0.1253
Echinococcus multilocularis peregrin 0.0032 0.0236 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0191 0.0526
Loa Loa (eye worm) hypothetical protein 0.0081 0.0982 0.3251
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0447 0.2243
Toxoplasma gondii thioredoxin reductase 0.0046 0.0447 0.5526
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0029 0.0191 0.0608
Schistosoma mansoni lipoxygenase 0.0054 0.0565 0.0565
Brugia malayi Carboxylesterase family protein 0.0081 0.0982 0.3201
Echinococcus granulosus dna polymerase eta 0.0019 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.003 0.02 0.0639
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0035 0.0277 0.0277
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.012 0.1582 0.5257
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0524 0.1722
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0029 0.0191 0.0526
Brugia malayi Choline O-acetyltransferase 0.0196 0.2735 0.9108
Onchocerca volvulus 0.0031 0.0211 0.051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1526 0.8062
Echinococcus multilocularis zinc finger protein 0.0019 0.0038 0.0038
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.02 0.02
Echinococcus granulosus acetylcholinesterase 0.0081 0.0982 0.0982
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0467 0.0467
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0054 0.0149
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0082 0.0082
Loa Loa (eye worm) acetylcholinesterase 1 0.0081 0.0982 0.3251
Echinococcus multilocularis acetylcholinesterase 0.0081 0.0982 0.0982
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0897
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0458 0.5
Plasmodium vivax glutathione reductase, putative 0.0046 0.0447 0.9747
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0128 0.052
Leishmania major carnitine palmitoyltransferase-like protein 0.0029 0.0191 0.0526
Echinococcus granulosus L aminoadipate semialdehyde 0.0166 0.2281 0.2281
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0029 0.0191 0.0526
Echinococcus granulosus carboxylesterase 5A 0.0081 0.0982 0.0982
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0458 0.1402
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0128 0.0235
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0458 0.5764
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0686 0.2263
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0031 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.0671 1 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0296 0.0296
Schistosoma mansoni polycystin 1-related 0.0019 0.0037 0.0037
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0128 0.0128
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.3072 1
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0128 0.052
Echinococcus multilocularis acetylcholinesterase 0.0081 0.0982 0.0982
Trypanosoma cruzi hypothetical protein, conserved 0.0218 0.3072 1
Brugia malayi hypothetical protein 0.012 0.1582 0.5222
Loa Loa (eye worm) carboxylesterase 0.0081 0.0982 0.3251
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0029 0.0191 0.0608
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0458 1
Leishmania major trypanothione reductase 0.0046 0.0447 0.1368
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0325 0.0325
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.02 0.02
Schistosoma mansoni choline o-acyltransferase 0.0029 0.0191 0.0191
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0029 0.0191 0.0526
Onchocerca volvulus 0.0029 0.0191 0.045
Brugia malayi Bromodomain containing protein 0.0032 0.0236 0.069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0283 0.0283
Onchocerca volvulus Huntingtin homolog 0.012 0.1582 0.4525
Loa Loa (eye worm) hypothetical protein 0.0029 0.0191 0.0608
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0191 0.0526
Brugia malayi Pre-SET motif family protein 0.0213 0.3 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0647 0.2024
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.0191 0.0526
Trypanosoma brucei trypanothione reductase 0.0046 0.0447 0.1368
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4128 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0082 0.0082
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.4128 1
Trichomonas vaginalis set domain proteins, putative 0.0242 0.345 0.8346
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0031 0.0073
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0447 0.0447
Onchocerca volvulus Huntingtin homolog 0.012 0.1582 0.4525
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1347 0.7097
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0647 0.3319
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0211 0.0211
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0647 0.3319
Schistosoma mansoni zinc finger protein 0.0019 0.0038 0.0038
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0029 0.0191 0.0526
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.1238 0.1238
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0597 0.0597
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0458 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0128 0.052
Onchocerca volvulus 0.0029 0.0191 0.045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0211 0.0245
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0325 0.0325
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0458 0.23

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 40 % Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 100 uM pre-incubated for 2 hrs before LPS stimulation for 16 hrs by Griess method ChEMBL. 26481151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.