Detailed information for compound 567136

Basic information

Technical information
  • TDR Targets ID: 567136
  • Name: (2S)-2-[[2-[[(2S)-2-aminopropanoyl]amino]acet yl]amino]-N-[2-[2-(1H-imidazol-5-yl)ethylamin o]acetyl]pentanediamide
  • MW: 424.455 | Formula: C17H28N8O5
  • H donors: 7 H acceptors: 6 LogP: -3.52 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](N)C)CCC(=O)N)CNCCc1cnc[nH]1
  • InChi: 1S/C17H28N8O5/c1-10(18)16(29)22-8-15(28)24-12(2-3-13(19)26)17(30)25-14(27)7-20-5-4-11-6-21-9-23-11/h6,9-10,12,20H,2-5,7-8,18H2,1H3,(H2,19,26)(H,21,23)(H,22,29)(H,24,28)(H,25,27,30)/t10-,12-/m0/s1
  • InChiKey: GCJYUUCHJZQFLE-JQWIXIFHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-[[2-[[(2S)-2-amino-1-oxopropyl]amino]-1-oxoethyl]amino]-N-[2-[2-(1H-imidazol-5-yl)ethylamino]-1-oxoethyl]pentanediamide
  • (2S)-2-[2-[[(2S)-2-azanylpropanoyl]amino]ethanoylamino]-N-[2-[2-(1H-imidazol-5-yl)ethylamino]ethanoyl]pentanediamide
  • (2S)-2-[[2-[[(2S)-2-aminopropanoyl]amino]acetyl]amino]-N-[2-[2-(1H-imidazol-5-yl)ethylamino]acetyl]glutaramide
  • procamine
  • (2S)-2-[[2-[[(2S)-2-aminopropanoyl]amino]acetyl]amino]-N-[2-[2-(3H-imidazol-4-yl)ethylamino]acetyl]pentanediamide
  • (2S)-2-[[2-[[(2S)-2-amino-1-oxopropyl]amino]-1-oxoethyl]amino]-N-[2-[2-(3H-imidazol-4-yl)ethylamino]-1-oxoethyl]pentanediamide
  • (2S)-2-[[2-(alanylamino)acetyl]amino]-N-[2-[2-(3H-imidazol-4-yl)ethylamino]acetyl]glutaramide
  • (2S)-2-[2-[[(2S)-2-aminopropanoyl]amino]ethanoylamino]-N-[2-[2-(3H-imidazol-4-yl)ethylamino]ethanoyl]pentanediamide
  • 51943-80-7
  • Glycinamide, L-alanylglycyl-L-glutaminyl-N-(2-(1H-imidazol-4-yl)ethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi mbt repeat family protein 0.0049 0.005 0.0442
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0028
Brugia malayi hypothetical protein 0.0147 0.025 0.2412
Onchocerca volvulus Glucosylceramidase homolog 0.0346 0.0653 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0009 0.0009
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.005 0.0359
Schistosoma mansoni hypothetical protein 0.0083 0.0119 0.0858
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Loa Loa (eye worm) STAT protein 0.0156 0.0267 0.2555
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0098 0.0342
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0227 0.0413 0.1425
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0148 0.049
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0527 0.1021 1
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.005 0.005
Echinococcus granulosus Niemann Pick C1 protein 0.0286 0.0532 0.3822
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0126 0.1154
Echinococcus granulosus tar DNA binding protein 0.0259 0.0476 0.342
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0413 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0585 0.5697
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0691 0.6738
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0296 0.0552 0.4482
Onchocerca volvulus 0.0049 0.005 0.0636
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0148 0.049
Schistosoma mansoni microtubule-associated protein tau 0.071 0.1393 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0025 0.0157
Plasmodium vivax importin-beta 2, putative 0.0029 0.0011 0.004
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0148 0.1407
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.019 0.1794
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0434 0.312
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0227 0.0413 0.2966
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0476 0.342
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0011 0.0013
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0029 0.0029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.009 0.0314
Loa Loa (eye worm) MBCTL1 0.0055 0.0064 0.054
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0009 0.0039
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0009 0.0065
Brugia malayi MH2 domain containing protein 0.0118 0.019 0.1825
Loa Loa (eye worm) hypothetical protein 0.0126 0.0207 0.1959
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0126 0.0903
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.005 0.0359
Echinococcus granulosus Niemann Pick C1 protein 0.02 0.0358 0.2569
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0097 0.0148 0.0517
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0039
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0227 0.0413 0.0413
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0009 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Brugia malayi Importin beta-1 subunit 0.0029 0.0011 0.0055
Brugia malayi CHE-14 protein 0.0086 0.0126 0.1188
Mycobacterium tuberculosis Conserved hypothetical protein 0.0329 0.062 0.2177
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1425 0.2846 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0286 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.02 0.0358 0.3448
Loa Loa (eye worm) hypothetical protein 0.0041 0.0034 0.0249
Onchocerca volvulus 0.0097 0.0148 0.2158
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Mycobacterium ulcerans hypothetical protein 0.0329 0.062 0.2154
Echinococcus granulosus geminin 0.0352 0.0667 0.4786
Mycobacterium ulcerans TetR family transcriptional regulator 0.1425 0.2846 1
Schistosoma mansoni hypothetical protein 0.0296 0.0552 0.396
Mycobacterium ulcerans transcriptional regulator 0.1425 0.2846 1
Echinococcus multilocularis microtubule associated protein 2 0.071 0.1393 0.1393
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0009 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0039
Brugia malayi hypothetical protein 0.0238 0.0434 0.4228
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1425 0.2846 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0059 0.0531
Loa Loa (eye worm) GMP reductase 0.01 0.0155 0.1446
Entamoeba histolytica hypothetical protein 0.0147 0.025 0.6909
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0625 0.1221 1
Plasmodium falciparum importin beta, putative 0.0029 0.0011 0.004
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.0016
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.013 0.0997
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.1021 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0059 0.0494
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.0169 0.1319
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0413 0.3334
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.034 0.2444
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0011 0.004
Brugia malayi Niemann-Pick C1 protein precursor 0.02 0.0358 0.3474
Loa Loa (eye worm) hypothetical protein 0.0097 0.0148 0.1374
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0064 0.0457
Loa Loa (eye worm) hypothetical protein 0.0075 0.0104 0.094
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0011 0.0011
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0009 0.0028
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0227 0.0413 0.1425
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.0148 0.049
Schistosoma mansoni bromodomain containing protein 0.0067 0.0088 0.0632
Entamoeba histolytica hypothetical protein 0.0147 0.025 0.6909
Onchocerca volvulus Huntingtin homolog 0.0126 0.0207 0.3077
Entamoeba histolytica acyl-coA synthetase, putative 0.0097 0.0148 0.3984
Loa Loa (eye worm) hypothetical protein 0.0097 0.0148 0.1374
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0227 0.0413 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.0476 0.4619
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.005 0.0405
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Trypanosoma brucei GMP reductase 0.0227 0.0413 0.3334
Loa Loa (eye worm) IMP dehydrogenase 1 0.0227 0.0413 0.3995
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0029 0.0208
Echinococcus multilocularis expressed conserved protein 0.0188 0.0333 0.0333
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0064 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.1021 1
Echinococcus granulosus microtubule associated protein 2 0.071 0.1393 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0059 0.0531
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.005 0.044
Brugia malayi mbt repeat family protein 0.0049 0.005 0.0442
Brugia malayi Bromodomain containing protein 0.008 0.0113 0.1066
Loa Loa (eye worm) TAR-binding protein 0.0259 0.0476 0.4619
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0011 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0231 0.1662
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0148 0.049
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0009 0.0028
Brugia malayi RNA binding protein 0.0259 0.0476 0.464
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0227 0.0413 0.1449
Echinococcus granulosus importin subunit beta 1 0.0029 0.0011 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0028
Echinococcus multilocularis snurportin 1 0.0312 0.0585 0.0585
Entamoeba histolytica hypothetical protein 0.0147 0.025 0.6909
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0227 0.0413 0.3334
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0148 0.049
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.034 0.034
Echinococcus multilocularis Niemann Pick C1 protein 0.02 0.0358 0.0358
Echinococcus granulosus snurportin 1 0.0312 0.0585 0.4203
Trypanosoma cruzi GMP reductase 0.0227 0.0413 0.3334
Onchocerca volvulus Putative GMP reductase 0.01 0.0155 0.2272
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0039
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0882
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0097 0.0148 0.049
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0148 0.1407
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.01 0.0155 0.1479
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.1021 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.009 0.0314
Onchocerca volvulus 0.0032 0.0017 0.0126
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0227 0.0413 0.4018
Schistosoma mansoni hypothetical protein 0.0036 0.0025 0.0179
Leishmania major inosine-5-monophosphate dehydrogenase 0.0227 0.0413 0.3334
Loa Loa (eye worm) hypothetical protein 0.0097 0.0148 0.1374
Brugia malayi hypothetical protein 0.0126 0.0207 0.199
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.01 0.0155 0.0516
Loa Loa (eye worm) hypothetical protein 0.0049 0.005 0.0405
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0064 0.0064
Onchocerca volvulus Huntingtin homolog 0.0126 0.0207 0.3077
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0127 0.0209 0.0705
Loa Loa (eye worm) hypothetical protein 0.0045 0.0043 0.034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0231 0.0231
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0227 0.0413 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0296 0.0552 0.4482
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.009 0.0314
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0413 0.3334
Loa Loa (eye worm) hypothetical protein 0.0043 0.0039 0.03
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0227 0.0413 0.2966
Echinococcus multilocularis geminin 0.0352 0.0667 0.0667
Loa Loa (eye worm) RNA binding protein 0.0259 0.0476 0.4619
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0009 0.0039
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1425 0.2846 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0148 0.3984
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.005 0.0636
Trichomonas vaginalis glucosylceramidase, putative 0.0364 0.0691 0.6738
Loa Loa (eye worm) hypothetical protein 0.0105 0.0165 0.1542
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.01 0.0155 0.0516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0148 0.0517
Schistosoma mansoni hypothetical protein 0.0083 0.0119 0.0858
Toxoplasma gondii IMP dehydrogenas 0.0227 0.0413 1
Onchocerca volvulus 0.0049 0.005 0.0634
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.013 0.0997
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0097 0.0148 0.049
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.005 0.0359
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0476 0.342
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0098 0.0315
Schistosoma mansoni hypothetical protein 0.0352 0.0667 0.4786
Echinococcus granulosus expressed conserved protein 0.0188 0.0333 0.2392
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.005 0.0359
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.008 0.0577
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0882
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.1021 1
Brugia malayi GMP reductase 0.01 0.0155 0.1479
Brugia malayi TAR-binding protein 0.0259 0.0476 0.464
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0064 0.0064
Echinococcus multilocularis protein dispatched 1 0.0098 0.015 0.015
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0025 0.0195
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0625 0.1221 1
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.1021 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0882
Loa Loa (eye worm) hypothetical protein 0.0238 0.0434 0.4206
Schistosoma mansoni transcription factor LCR-F1 0.0147 0.025 0.1795
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0476 0.342
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0203 0.0364 0.2615
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0126 0.0903
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.02 0.0358 1
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0009 0.0065
Echinococcus multilocularis protein patched 0.0086 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0053 0.0059 0.0494
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0127 0.0209 0.0731
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0148 0.1146
Loa Loa (eye worm) hypothetical protein 0.0126 0.0207 0.1959
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.005 0.0359
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0231 0.1662
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Schistosoma mansoni hypothetical protein 0.0352 0.0667 0.4786
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0527 0.1021 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0156 0.0267 0.2584
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0147 0.025 0.025
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.009 0.0314
Schistosoma mansoni hypothetical protein 0.0083 0.0119 0.0858
Leishmania major mitochondrial DNA polymerase beta 0.0625 0.1221 1
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0434 0.0434
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0009 0.0039
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0231 0.2229
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0098 0.2208
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0009 0.0028
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0098 0.2208
Schistosoma mansoni hypothetical protein 0.0083 0.0119 0.0858
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0064 0.0577
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.0476 0.464
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0882
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0009 0.0028
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0625 0.1221 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.01 0.0155 0.1479
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0148 0.1146
Schistosoma mansoni importin beta-1 0.0029 0.0011 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0231 0.1662
Schistosoma mansoni hypothetical protein 0.0312 0.0585 0.4203
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.019 0.1794
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0148 0.049
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.013 0.0997
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0231 0.2199
Loa Loa (eye worm) hypothetical protein 0.0072 0.0098 0.0882
Brugia malayi RNA, U transporter 1 0.0083 0.012 0.1133
Toxoplasma gondii hypothetical protein 0.0101 0.0156 0.3639
Trichomonas vaginalis glucosylceramidase, putative 0.0527 0.1021 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0126 0.0126
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0296 0.0552 0.4482
Brugia malayi Bromodomain containing protein 0.0041 0.0034 0.0285
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0147 0.025 0.1795
Schistosoma mansoni hypothetical protein 0.0147 0.025 0.1795
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0097 0.0148 0.049
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0049 0.005 0.0358
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0227 0.0413 0.3334
Mycobacterium ulcerans hypothetical protein 0.0097 0.0148 0.049
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.008 0.008
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0476 0.342
Loa Loa (eye worm) hypothetical protein 0.0055 0.0064 0.054
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0098 0.5
Trypanosoma cruzi GMP reductase 0.0227 0.0413 0.3334
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0148 0.1146
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.013 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0126 0.1154
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0028
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0148 0.3984
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0148 0.1407
Schistosoma mansoni survival motor neuron protein 0.0049 0.005 0.0358
Entamoeba histolytica hypothetical protein 0.0147 0.025 0.6909
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0009 0.0028
Leishmania major guanosine monophosphate reductase 0.0227 0.0413 0.3334
Echinococcus multilocularis tar DNA binding protein 0.0259 0.0476 0.0476
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0009 0.0028
Loa Loa (eye worm) hypothetical protein 0.0086 0.0126 0.1154
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0227 0.0413 0.1425
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0476 0.342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0231 0.1662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0231 0.1662
Trichomonas vaginalis glucosylceramidase, putative 0.0346 0.0653 0.6365
Schistosoma mansoni patched 1 0.0086 0.0126 0.0903
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0064 0.0457

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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