Detailed information for compound 569975

Basic information

Technical information
  • TDR Targets ID: 569975
  • Name: 1-(2-methoxyphenyl)-N-methyl-propan-2-amine
  • MW: 179.259 | Formula: C11H17NO
  • H donors: 1 H acceptors: 0 LogP: 2.16 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(Cc1ccccc1OC)C
  • InChi: 1S/C11H17NO/c1-9(12-2)8-10-6-4-5-7-11(10)13-3/h4-7,9,12H,8H2,1-3H3
  • InChiKey: OEHAYUOVELTAPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2-methoxyphenyl)-N-methyl-2-propanamine
  • [2-(2-methoxyphenyl)-1-methyl-ethyl]-methyl-amine
  • 1-(2-methoxyphenyl)-N-methylpropan-2-amine
  • methoxyphenamine
  • Proasma
  • o-Methoxy-N,alpha-dimethylphenethylamine
  • N-methyl-1-[2-(methyloxy)phenyl]propan-2-amine
  • NCGC00159469-02
  • NCI60_019552
  • Benzeneethanamine, 2-methoxy-N,.alpha.-dimethyl-
  • NCGC00159469-03
  • Phenethylamine, o-methoxy-N,.alpha.-dimethyl-
  • 2-Methoxy-N,alpha-dimethylphenethylamin
  • Asmi
  • EINECS 202-237-7
  • Euspirol
  • Methoxifenaminio
  • Methoxiphenadrinum
  • Methoxyphenaminum [INN-Latin]
  • Metossifenamina [DCIT]
  • Metoxifenaminio [INN-Spanish]
  • Orthoxine
  • Oxalacetic acid orthoxine
  • Phenethylamine, 2-methoxy-N,alpha-dimethyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0084 0.2565 0.3577
Loa Loa (eye worm) hypothetical protein 0.0039 0.0914 0.1143
Brugia malayi beta-lactamase 0.0039 0.0914 0.1143
Mycobacterium leprae Probable lipase LipE 0.0039 0.0914 0.5
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.1458 0.1338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0914 0.1143
Leishmania major carbonic anhydrase-like protein 0.0054 0.1458 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0912 0.1248
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0241 0.0166
Loa Loa (eye worm) hypothetical protein 0.0021 0.0241 0.0152
Schistosoma mansoni zinc finger protein 0.004 0.0954 0.0828
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.1458 0.1945
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0138 0.5
Mycobacterium ulcerans lipase LipD 0.0039 0.0914 1
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.1458 0.1338
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0241 0.1329
Echinococcus multilocularis zinc finger protein 0.004 0.0954 0.1316
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0241 0.1654
Brugia malayi beta-lactamase family protein 0.0039 0.0914 0.1143
Brugia malayi PHD-finger family protein 0.0051 0.136 0.1802
Loa Loa (eye worm) hypothetical protein 0.0054 0.1458 0.1945
Mycobacterium tuberculosis Conserved protein 0.0039 0.0914 0.0903
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0241 0.078
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0912 0.0785
Schistosoma mansoni hypothetical protein 0.0165 0.5542 0.5479
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0762 0.0633
Loa Loa (eye worm) MBCTL1 0.0053 0.1412 0.1877
Toxoplasma gondii ABC1 family protein 0.0039 0.0914 0.5877
Echinococcus multilocularis carbonic anhydrase II 0.0054 0.1458 0.2127
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0534 0.0401
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0241 0.0152
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.1832 0.273
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0241 0.078
Schistosoma mansoni carbonic anhydrase-related 0.0054 0.1458 0.1338
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0914 0.0903
Onchocerca volvulus 0.0039 0.0914 0.0512
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0809 0.0989
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0047 0.118 0.1057
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.1175 0.1051
Trichomonas vaginalis esterase, putative 0.0039 0.0914 0.0992
Echinococcus granulosus carbonic anhydrase 0.0054 0.1458 0.2127
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0914 0.0903
Entamoeba histolytica hypothetical protein 0.0039 0.0912 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0054 0.1458 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.1175 0.1051
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0912 0.1248
Echinococcus multilocularis carbonic anhydrase 0.0054 0.1458 0.2127
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0914 0.0992
Giardia lamblia DINP protein human, muc B family 0.0021 0.0241 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0241 0.078
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.1175 0.1051
Schistosoma mansoni bromodomain containing protein 0.0131 0.4281 0.4201
Loa Loa (eye worm) hypothetical protein 0.0053 0.1412 0.1877
Loa Loa (eye worm) hypothetical protein 0.0054 0.1458 0.1945
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0914 0.0903
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0914 0.0903
Mycobacterium tuberculosis Conserved protein 0.0039 0.0914 0.0903
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Leishmania major hypothetical protein, conserved 0.0032 0.0629 0.3718
Toxoplasma gondii hypothetical protein 0.0054 0.1458 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.1832 0.2497
Echinococcus granulosus fetal alzheimer antigen falz 0.0047 0.118 0.168
Onchocerca volvulus 0.023 0.7953 1
Brugia malayi Bromodomain containing protein 0.0155 0.5173 0.7422
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.1175 0.1671
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0762 0.1006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0914 0.1143
Onchocerca volvulus 0.0039 0.0914 0.0512
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0914 0.0903
Entamoeba histolytica hypothetical protein 0.0039 0.0912 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0054 0.1458 0.1945
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0914 0.125
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.1175 0.1671
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.6342 1
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.1035 0.1322
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.1832 0.273
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.1175 0.1671
Leishmania major DNA polymerase kappa, putative 0.0021 0.0241 0.078
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0241 0.0152
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0241 0.078
Echinococcus multilocularis dna polymerase eta 0.0021 0.0241 0.0166
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0914 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0241 0.0132
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0241 0.1327
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0054 0.1458 0.1338
Brugia malayi mbt repeat family protein 0.0046 0.1175 0.1528
Mycobacterium ulcerans beta-lactamase 0.0039 0.0914 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0914 0.0786
Onchocerca volvulus 0.0046 0.1175 0.0864
Brugia malayi beta-lactamase family protein 0.0039 0.0914 0.1143
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0914 0.0992
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0047 0.118 0.168
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0241 0.0132
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.1175 0.1528
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0914 0.0992
Echinococcus granulosus zinc finger protein 0.004 0.0954 0.1316
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.2199 0.3322
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.1175 0.1671
Loa Loa (eye worm) hypothetical protein 0.0088 0.271 0.3792
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0914 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0241 0.1654
Brugia malayi MH2 domain containing protein 0.013 0.427 0.609
Trypanosoma cruzi ISWI complex protein 0.0032 0.0629 0.3718
Trypanosoma cruzi ISWI complex protein 0.0032 0.0629 0.3718
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.1412 0.1877
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0762 0.0633
Echinococcus multilocularis geminin 0.0165 0.5542 0.871
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.1412 0.1291
Trypanosoma brucei carbonic anhydrase-like protein 0.0054 0.1458 1
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0914 0.6268
Loa Loa (eye worm) hypothetical protein 0.0054 0.1458 0.1945
Mycobacterium ulcerans hypothetical protein 0.0039 0.0914 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.2199 0.3322
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0534 0.3
Trichomonas vaginalis set domain proteins, putative 0.023 0.7953 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Loa Loa (eye worm) hypothetical protein 0.0079 0.2385 0.3312
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0914 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0123 0.4008 0.6239
Echinococcus granulosus geminin 0.0165 0.5542 0.871
Loa Loa (eye worm) hypothetical protein 0.0039 0.0914 0.1143
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0914 0.0903
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0534 0.0401
Onchocerca volvulus 0.0039 0.0914 0.0512
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.427 0.609
Echinococcus multilocularis carbonic anhydrase 0.0054 0.1458 0.2127
Schistosoma mansoni carbonic anhydrase 0.0054 0.1458 0.1338
Schistosoma mansoni hypothetical protein 0.0043 0.1035 0.0909
Echinococcus granulosus carbonic anhydrase II 0.0054 0.1458 0.2127
Schistosoma mansoni DNA polymerase eta 0.0021 0.0241 0.0104
Loa Loa (eye worm) hypothetical protein 0.0146 0.4847 0.6942
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0241 0.012
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0241 0.0166
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0914 0.125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0534 0.0638
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0138 0.0948
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.1458 0.1945
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.1458 0.1945
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0914 0.0992
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0914 0.5877
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.1458 0.1945
Schistosoma mansoni hypothetical protein 0.0054 0.1458 0.1338
Schistosoma mansoni hypothetical protein 0.0032 0.0629 0.0497
Brugia malayi hypothetical protein 0.0039 0.0912 0.1141
Brugia malayi Bromodomain containing protein 0.0079 0.2379 0.3304
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0138 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.8723 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0241 0.012
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0914 0.0903
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0914 0.5877
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0241 0.078
Loa Loa (eye worm) beta-lactamase 0.0039 0.0914 0.1143
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.6342 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.1458 0.1945
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.1175 0.0864
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.1412 0.2053
Brugia malayi Pre-SET motif family protein 0.0029 0.0534 0.0583
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0241 0.0104
Echinococcus granulosus carbonic anhydrase 0.0054 0.1458 0.2127
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0914 0.0786
Leishmania major hypothetical protein, conserved 0.0039 0.0914 0.5877
Echinococcus granulosus carbonic anhydrase 0.0054 0.1458 0.2127
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0495 0.0575
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0241 0.1327
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0914 0.0992
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0054 0.1458 0.1945
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.427 0.609
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0054 0.1458 0.1338
Brugia malayi Pre-SET motif family protein 0.0202 0.6922 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1832 0.1718
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.1412 0.2053
Leishmania major DNA polymerase eta, putative 0.0021 0.0241 0.078
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0054 0.1458 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.6922 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0054 0.1458 0.1945
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0914 0.1143
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0241 0.1654
Schistosoma mansoni hypothetical protein 0.0039 0.0912 0.0785
Trypanosoma brucei ISWI complex protein 0.0032 0.0629 0.4314
Entamoeba histolytica hypothetical protein 0.0039 0.0912 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0241 0.078
Loa Loa (eye worm) carbonic anhydrase 3 0.0054 0.1458 0.1945
Brugia malayi mbt repeat family protein 0.0046 0.1175 0.1528
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Mycobacterium tuberculosis Conserved protein 0.0039 0.0914 0.0903
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Plasmodium falciparum carbonic anhydrase 0.0054 0.1458 1
Echinococcus multilocularis carbonic anhydrase 0.0054 0.1458 0.2127
Entamoeba histolytica hypothetical protein 0.0039 0.0912 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.1412 0.2053
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.1412 0.2053
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0241 0.0104
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0241 0.1654
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0241 0.1654
Loa Loa (eye worm) hypothetical protein 0.0039 0.0914 0.1143
Schistosoma mansoni zinc finger protein 0.0032 0.0629 0.0497
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0762 0.1006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.1832 0.1718
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0241 0.0152
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0914 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.1175 0.1528
Echinococcus granulosus dna polymerase eta 0.0021 0.0241 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0914 0.1143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0914 0.1143
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0054 0.1458 0.1945
Schistosoma mansoni hypothetical protein 0.0165 0.5542 0.5479
Plasmodium vivax SET domain protein, putative 0.0029 0.0534 0.5105
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0241 0.0166
Echinococcus granulosus dna polymerase kappa 0.0021 0.0241 0.0166
Trypanosoma brucei unspecified product 0.0021 0.0241 0.1654
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0123 0.4008 0.6239

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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