Detailed information for compound 570499

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 612.715 | Formula: C35H40N4O6
  • H donors: 4 H acceptors: 7 LogP: 4.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: COC(=O)C1C(=O)c2c3=C1C1=NC(=Cc4[nH]c(c(c4C)C(O)C)C=C4N=C(C=c(c2C)[nH]3)C(CC)C4C)[C@H]([C@@H]1CCC(=O)O)C
  • InChi: 1S/C35H40N4O6/c1-8-19-14(2)21-13-26-28(18(6)40)16(4)23(37-26)11-22-15(3)20(9-10-27(41)42)32(38-22)30-31(35(44)45-7)34(43)29-17(5)24(39-33(29)30)12-25(19)36-21/h11-15,18-20,31,37,39-40H,8-10H2,1-7H3,(H,41,42)/b21-13-,22-11-,23-11-,24-12-,25-12-,26-13-,32-30-/t14?,15-,18?,19?,20-,31?/m0/s1
  • InChiKey: QSAXNKPPNFJDHI-PXAYEBIFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0157 0.0357 0.0335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0015 0.0057
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Schistosoma mansoni patched 1 0.0042 0.0062 0.0039
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0048 0.0077 0.0055
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.0182 0.0421 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0204 0.0182
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0115 0.0093
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Echinococcus granulosus ectonucleotide 0.0255 0.0609 0.0588
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0042 0.0062 0.0062
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.1045 0.2638 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0302 0.0731 0.071
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0157 0.0357 0.0335
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Echinococcus multilocularis dual specificity 0.009 0.0186 0.0163
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.151 0.3834 1
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0081
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0157 0.0357 0.0335
Onchocerca volvulus 0.0147 0.0331 0.0828
Brugia malayi hypothetical protein 0.0035 0.0046 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0115 0.0093
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.151 0.3834 0.3834
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.151 0.3834 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Mycobacterium ulcerans hypothetical protein 0.0048 0.0077 0.0201
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.022 0.0417
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Echinococcus multilocularis expressed conserved protein 0.0091 0.0189 0.0167
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0081
Echinococcus granulosus mitogen activated protein kinase 0.0103 0.022 0.0197
Echinococcus granulosus Endonuclease G 0.0182 0.0421 0.0399
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0208 0.0186
Onchocerca volvulus 0.0147 0.0331 0.0828
Loa Loa (eye worm) protein-tyrosine phosphatase 0.3912 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0302 0.0731 0.0731
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0147 0.0331 0.0309
Onchocerca volvulus 0.0147 0.0331 0.0828
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0023 0.0023
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0182 0.0421 0.3306
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0061 0.0231
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0157 0.0357 0.0335
Onchocerca volvulus 0.0147 0.0331 0.0828
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0036
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0061 0.7393
Echinococcus multilocularis protein dispatched 1 0.0048 0.0077 0.0055
Trypanosoma cruzi endonuclease G, putative 0.0182 0.0421 0.3306
Onchocerca volvulus 0.0147 0.0331 0.0828
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0157 0.0357 0.0335
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Loa Loa (eye worm) hypothetical protein 0.0158 0.036 0.036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Onchocerca volvulus 0.0302 0.0731 0.1875
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0048 0.0077 0.0162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0051 0.0086 0.0086
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.151 0.3834 1
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0081
Brugia malayi Protein-tyrosine phosphatase 0.0314 0.0762 0.0748
Leishmania major endonuclease G, putative 0.0182 0.0421 0.3576
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0147 0.0331 0.0317
Entamoeba histolytica hypothetical protein 0.009 0.0186 0.0447
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0061 0.0038
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0061 0.0038
Loa Loa (eye worm) hypothetical protein 0.0302 0.0731 0.0731
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0103 0.022 0.1454
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0302 0.0731 0.071
Trypanosoma brucei protein kinase, putative 0.0103 0.022 0.1326
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0061 1
Trypanosoma brucei endonuclease G, putative 0.0182 0.0421 0.3205
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0103 0.022 0.1799
Echinococcus multilocularis mitogen activated protein kinase 0.0103 0.022 0.0197
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.3912 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0304 0.0736 0.0736
Brugia malayi AEL166Cp 0.0048 0.0077 0.0062
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Giardia lamblia Kinase, CMGC MAPK 0.0103 0.022 0.0379
Loa Loa (eye worm) hypothetical protein 0.0026 0.0023 0.0023
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0157 0.0357 0.0335
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0157 0.0357 0.0335
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.022 0.1454
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0061 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0115 0.0093
Brugia malayi Muscleblind-like protein 0.0147 0.0333 0.0318
Onchocerca volvulus 0.0147 0.0331 0.0828
Schistosoma mansoni hypothetical protein 0.0048 0.0077 0.0055
Loa Loa (eye worm) hypothetical protein 0.0158 0.036 0.036
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0048 0.0077 0.0055
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.151 0.3834 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0311 0.0289
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus granulosus tar DNA binding protein 0.0062 0.0115 0.0093
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Entamoeba histolytica protein kinase, putative 0.009 0.0186 0.0447
Trypanosoma cruzi hypothetical protein, conserved 0.0466 0.1151 1
Onchocerca volvulus 0.0147 0.0331 0.0828
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Onchocerca volvulus GPI ethanolamine phosphate transferase 3 homolog 0.0048 0.0077 0.0162
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0115 0.0115
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0103 0.022 0.1799
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0103 0.022 0.1454
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0157 0.0357 0.0335
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0147 0.0331 0.0317
Trypanosoma brucei protein tyrosine phosphatase 1 0.0147 0.0331 0.2368
Echinococcus multilocularis mitogen activated protein kinase 3 0.0103 0.022 0.0197
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Schistosoma mansoni protein tyrosine phosphatase 0.0147 0.0331 0.0309
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0585 0.1458 0.3804
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0157 0.0357 0.0335
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0147 0.0331 0.0309
Schistosoma mansoni amine oxidase 0.0041 0.0061 0.0038
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Echinococcus multilocularis 0.0147 0.0331 0.0309
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0147 0.0331 0.0309
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0061 0.0038
Loa Loa (eye worm) hypothetical protein 0.0087 0.018 0.018
Onchocerca volvulus 4.1 G protein, putative homolog 0.0147 0.0331 0.0828
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.3912 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0061 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0302 0.0731 0.071
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0333 0.0311
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0036
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0061 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0147 0.0331 0.0309
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0147 0.0331 0.0828
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0147 0.0331 0.0309
Echinococcus multilocularis geminin 0.0165 0.038 0.0358
Mycobacterium ulcerans oxidoreductase 0.0041 0.0061 0.0159
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0302 0.0731 0.071
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0147 0.0333 0.0333
Giardia lamblia Protein tyrosine phosphatase 0.0147 0.0331 0.0677
Loa Loa (eye worm) protein tyrosine phosphatase 0.0147 0.0331 0.0331
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0115 0.0093
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0147 0.0331 0.0331
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.022 0.0417
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0302 0.0731 0.0717
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0147 0.0331 0.0309
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0204 0.0495
Brugia malayi Protein-tyrosine phosphatase 0.0147 0.0331 0.0317
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0062 0.0039
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0061 0.0038
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0061 0.0159
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Onchocerca volvulus 0.0302 0.0731 0.1875
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0147 0.0331 0.0309
Onchocerca volvulus 0.0652 0.163 0.4229
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog 0.0048 0.0077 0.0162
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0046 0.0024
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0157 0.0357 0.0335
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0147 0.0331 0.0309
Brugia malayi hypothetical protein 0.0147 0.0331 0.0317
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0159 0.0363 0.0349
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.151 0.3834 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.151 0.3834 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0157 0.0357 0.0335
Schistosoma mansoni hypothetical protein 0.0165 0.038 0.0358
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0061 0.0231
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0061 1
Echinococcus multilocularis Endonuclease G 0.0182 0.0421 0.0399
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.0182 0.0421 0.3306
Echinococcus granulosus protein tyrosine phosphatase n9 0.0147 0.0331 0.0309
Loa Loa (eye worm) hypothetical protein 0.0147 0.0333 0.0333
Schistosoma mansoni protein tyrosine phosphatase 0.0157 0.0357 0.0335
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.0186 0.0186
Leishmania major tyrosine specific protein phosphatase, putative 0.0147 0.0331 0.2785
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Echinococcus granulosus transferase 0.0048 0.0077 0.0055
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0147 0.0331 0.0309
Brugia malayi Protein-tyrosine phosphatase 1 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Trypanosoma cruzi endonuclease G, putative 0.0182 0.0421 0.3306
Schistosoma mansoni hypothetical protein 0.0652 0.163 0.1611
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Schistosoma mansoni hypothetical protein 0.0048 0.0077 0.0055
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0147 0.0331 0.0309
Onchocerca volvulus 0.0147 0.0331 0.0828
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Brugia malayi hypothetical protein 0.0048 0.0077 0.0062
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0046 0.0024
Loa Loa (eye worm) hypothetical protein 0.0087 0.018 0.018
Onchocerca volvulus 0.0147 0.0331 0.0828
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0147 0.0331 0.2481
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0147 0.0331 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0115 0.0093
Onchocerca volvulus 0.0147 0.0331 0.0828
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0147 0.0331 0.0309
Schistosoma mansoni protein tyrosine phosphatase 0.0147 0.0331 0.0309
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0147 0.0331 0.2481
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0115 0.0115
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0015 0.004
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0157 0.0357 0.0335
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0061 0.7905
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0159 0.0363 0.0341
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0048 0.0077 0.0062
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Brugia malayi Protein kinase domain containing protein 0.009 0.0186 0.0171
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Brugia malayi hypothetical protein 0.0147 0.0331 0.0317
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0062 0.0039
Echinococcus granulosus expressed conserved protein 0.0091 0.0189 0.0167
Brugia malayi SWIRM domain containing protein 0.0041 0.0061 0.0046
Mycobacterium ulcerans dehydrogenase 0.0041 0.0061 0.0159
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0115 0.01
Onchocerca volvulus 0.0147 0.0331 0.0828
Brugia malayi CHE-14 protein 0.0042 0.0062 0.0047
Trichomonas vaginalis pten, drome, putative 0.0147 0.0331 0.0714
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0097 0.0204 0.0204
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0204 0.0182
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0159 0.0363 0.0341
Entamoeba histolytica protein kinase, putative 0.009 0.0186 0.0447
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0159 0.0363 0.0341
Echinococcus multilocularis muscleblind protein 0.0147 0.0333 0.0311
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0159 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.0186 0.1011
Brugia malayi RNA binding protein 0.0062 0.0115 0.01
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0147 0.0331 0.0309
Schistosoma mansoni hypothetical protein 0.0165 0.038 0.0358
Echinococcus granulosus geminin 0.0165 0.038 0.0358
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0147 0.0331 0.0828
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0103 0.022 0.1326
Schistosoma mansoni hypothetical protein 0.0048 0.0077 0.0055
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Entamoeba histolytica protein tyrosine phosphatase, putative 0.151 0.3834 1
Loa Loa (eye worm) hypothetical protein 0.0302 0.0731 0.0731
Echinococcus granulosus mitogen activated protein kinase 3 0.0103 0.022 0.0197
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0585 0.1458 0.3804
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0147 0.0331 0.0828
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0159 0.0363 0.0363
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0186 0.0163
Onchocerca volvulus 0.0168 0.0386 0.0971
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0157 0.0357 0.0357
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0157 0.0357 0.0335
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0115 0.0093
Brugia malayi intermediate filament protein 0.0026 0.0023 0.0008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0048 0.0077 0.0055
Schistosoma mansoni hypothetical protein 0.0035 0.0046 0.0024
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.004
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0103 0.022 0.022
Schistosoma mansoni hypothetical protein 0.004 0.0058 0.0036
Leishmania major hypothetical protein, conserved 0.0466 0.1151 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0062 0.0039
Echinococcus multilocularis hypothetical protein 0.0147 0.0331 0.0309
Brugia malayi hypothetical protein 0.0041 0.0061 0.0046
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0048 0.0077 0.0055
Leishmania major UDP-galactopyranose mutase 0.0041 0.0061 0.0404
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0061 0.0046
Brugia malayi TAR-binding protein 0.0062 0.0115 0.01
Loa Loa (eye worm) hypothetical protein 0.0255 0.0609 0.0609
Onchocerca volvulus 0.0026 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.0182 0.0421 0.3576
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0157 0.0357 0.0335
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0023 0.0008
Schistosoma mansoni pcd6 interacting protein-related 0.0147 0.0331 0.0309
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0048 0.0077 0.0162
Echinococcus granulosus muscleblind protein 0.0147 0.0333 0.0311
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.151 0.3834 0.3824
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.0186 0.1502
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Mycobacterium ulcerans hypothetical protein 0.0023 0.0015 0.004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0466 0.1151 1
Onchocerca volvulus 0.0041 0.0061 0.012
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Brugia malayi hypothetical protein 0.0147 0.0331 0.0317
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0147 0.0331 0.0309
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0048 0.0077 0.0055
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0147 0.0331 0.0309
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0061 0.0159
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0147 0.0331 0.0309
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Onchocerca volvulus 0.151 0.3834 1
Leishmania major ethanolamine phosphotransferase, putative 0.0048 0.0077 0.0546
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.004
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0159 0.0363 0.0911
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0048 0.0077 0.0162
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0048 0.0077 0.0055
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Schistosoma mansoni amine oxidase 0.0041 0.0061 0.0038
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.0186 0.1144
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0048 0.0077 0.0055
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.0186 0.1144
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0015 0.004
Brugia malayi hypothetical protein 0.0048 0.0077 0.0062
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Echinococcus granulosus dual specificity 0.009 0.0186 0.0163
Schistosoma mansoni hypothetical protein 0.0048 0.0077 0.0055
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0255 0.0609 0.0588
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0147 0.0331 0.2785
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0061 1
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.0652 0.163 0.163
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0157 0.0357 0.0335
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0204 0.0189
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0147 0.0331 0.0309
Brugia malayi Thrombospondin type 1 domain containing protein 0.0652 0.163 0.1617
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0147 0.0331 0.0309
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0103 0.022 0.1454
Trypanosoma brucei endonuclease G, putative 0.0182 0.0421 0.3205
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0544 0.1352 0.5127
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0015 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0046 0.0024
Echinococcus multilocularis transferase 0.0048 0.0077 0.0055
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Onchocerca volvulus GPI ethanolamine phosphate transferase 2 homolog 0.0048 0.0077 0.0162
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0255 0.0609 0.0588
Onchocerca volvulus 0.0026 0.0023 0.002
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.022 0.0197
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0061 0.0038
Onchocerca volvulus Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog 0.0048 0.0077 0.0162
Onchocerca volvulus 0.0147 0.0331 0.0828
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0048 0.0077 0.0077
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.151 0.3834 1
Onchocerca volvulus 0.0147 0.0331 0.0828
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0015 0.004
Entamoeba histolytica protein kinase domain containing protein 0.009 0.0186 0.0447
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0061 0.7905
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.151 0.3834 1
Mycobacterium leprae hypothetical protein 0.0048 0.0077 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0015 0.0057
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.3912 1 1
Brugia malayi MAP kinase sur-1 0.0103 0.022 0.0205
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0048 0.0077 1
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0048 0.0077 0.0055
Trypanosoma brucei endonuclease G, putative 0.0182 0.0421 0.3205
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0147 0.0331 0.0317
Onchocerca volvulus 0.0147 0.0331 0.0828
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0147 0.0331 0.2481
Brugia malayi hypothetical protein 0.0147 0.0331 0.0317
Loa Loa (eye worm) hypothetical protein 0.0158 0.036 0.036
Entamoeba histolytica hypothetical protein 0.0035 0.0046 0.0081
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0147 0.0331 0.0331
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0061 0.7905
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0147 0.0331 0.0309
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0466 0.1151 0.2887
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0147 0.0331 0.0309
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Loa Loa (eye worm) RNA binding protein 0.0062 0.0115 0.0115
Echinococcus multilocularis ectonucleotide 0.0255 0.0609 0.0588
Echinococcus multilocularis protein patched 0.0042 0.0062 0.0039
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0302 0.0731 0.071
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0311 0.0289
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0041 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0015
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0466 0.1151 1
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.022 0.0417
Onchocerca volvulus 0.0147 0.0331 0.0828
Schistosoma mansoni endonuclease related 0.0182 0.0421 0.0399
Trichomonas vaginalis CMGC family protein kinase 0.0103 0.022 0.0417
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0466 0.1151 0.2887
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0103 0.022 0.4399
Brugia malayi endonuclease G, mitochondrial precursor 0.0182 0.0421 0.0407
Echinococcus multilocularis 0.0041 0.0061 0.0038
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.0147 0.0331 0.0331
Brugia malayi Protein kinase domain containing protein 0.0159 0.0363 0.0349
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0147 0.0331 0.0309
Brugia malayi hypothetical protein 0.0147 0.0331 0.0317
Entamoeba histolytica protein tyrosine phosphatase, putative 0.151 0.3834 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0147 0.0331 0.0331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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